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Artykuły w czasopismach na temat „MiRNA-10b”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Xu, Dong, Chiang-Ching Huang, Akadia Kachaochana, et al. "MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis." Journal of Rheumatology 43, no. 1 (2015): 161–68. http://dx.doi.org/10.3899/jrheum.141474.

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Objective.To identify differentially expressed microRNA (miRNA) in muscle biopsies (MBx) from 15 untreated children with juvenile dermatomyositis (JDM) compared with 5 controls.Methods.Following MBx miRNA profiling, differentially expressed miRNA and their protein targets were validated by quantitative real-time PCR (qRT-PCR) and immunological assay. The association of miRNA-10a and miRNA-10b with clinical data was evaluated, including Disease Activity Score (DAS), von Willebrand factor antigen (vWF:Ag), nailfold capillary end row loops, duration of untreated disease, and tumor necrosis factor

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Łosiewicz, Katarzyna, Małgorzata Chmielewska-Krzesińska, Piotr Socha, Anna Jakimiuk, and Krzysztof Wąsowicz. "MiRNA-21, miRNA-10b, and miRNA-34a Expression in Canine Mammary Gland Neoplasms." Bulletin of the Veterinary Institute in Pulawy 58, no. 3 (2014): 447–51. http://dx.doi.org/10.2478/bvip-2014-0068.

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Abstract The expression of miRNA-21, miRNA-10b, and miRNA-34a in malignant and benign tumours and non-neoplastic lesions in canine mammary gland, using real-time PCR with TaqMan probes was determined. The expression in normal tissues was compared to neoplastic and non-neoplastic lesions using one-way ANOVA test. Significant changes in miRNA expression in neoplastic tissues, as compared to normal ones, were demonstrated. In all neoplastic tissues, the miRNA-21 expression increased while in non-neoplastic lesions slightly decreased in comparison to normal ones. MiRNA-10b expression in malignant

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Chehkun, V. F., T. Borikun, and N. Yu Lukianova. "EFFECT OF 5-AZACYTIDINE ON miRNA EXPRESSION IN HUMAN BREAST CANCER CELLS WITH DIFFERENT SENSITIVITY TO CYTOSTATICS." Experimental Oncology 38, no. 1 (2016): 26–30. http://dx.doi.org/10.31768/2312-8852.2016.38(1):26-30.

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Aim: To analyze expression of miRNA in human breast cancer cells, sensitive and resistant to cisplatin and doxorubicin, and to explore possible modification of drug sensitivity via treatment of cells with 5-azacytidine (5-aza), a demethylating agent. Materials and Methods: The study was performed on wild-type MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to doxorubicin and cisplatin, respectively. Cells were treated with 5-aza, cisplatin, doxorubicin and their combinations. Relative expression levels of miRNA-221, -200b, -320a, -10b, -34a, -122 and -29b were

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Abdallah, Mays, Ismail H. Aziz, and Ahmed Zuhair Alsammarraie. "Assessment of miRNA-10b Expression Levels as a Potential Precursor to Metastasis in Localized and Locally Advanced/Metastatic Breast Cancer among Iraqi Patients." International Journal of Breast Cancer 2024 (February 28, 2024): 1–8. http://dx.doi.org/10.1155/2024/2408355.

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Breast cancer (BC) stands as the most prevalent form of carcinoma among women, ranking as the second leading cause of cancer-related mortality in the female population. The objective of this study is to assess the expression of miR-10b and determine its diagnostic and prognostic significance in breast cancer patients across various disease stages. The investigation was carried out in Baghdad at the Oncology Teaching Hospital within Baghdad Medical City and the Oncology Unit at Al-Yarmouk Teaching Hospital. A total of 150 samples were included and divided into two groups: the blood group consis

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Niedźwiecki, Sebastian, Janusz Piekarski, Bożena Szymańska, Zofia Pawłowska, and Arkadiusz Jeziorski. "Expression level of serum circulating miRNA-21, miRNA-10b and miRNA-200c in breast cancer patients with sentinel lymph node metastasis*." Postępy Higieny i Medycyny Doświadczalnej 73 (June 25, 2019): 325–32. http://dx.doi.org/10.5604/01.3001.0013.2562.

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MicroRNAs (miRNAs) act a role in regulation numerous processes crucial for oncogenesis. The aim of the study was to compare the blood serum concentrations of selected microRNAs (miRNA-21, miRNA-10b and miRNA-200c) between breast cancer patients without sentinel lymph node metastasis (Group 1) and those with metastasis (Group 2). The serum levels of miRNA-21, miRNA-10b and miRNA-200c were measured with using TaqMan PCR assays performed on a 7900HT Fast Real-Time PCR System in two groups of breast cancer patients: Group 1 – without sentinel lymph node metastasis (32 patients) and Group 2 – with

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Jurj, Maria-Ancuta, Michael A. Attathikhun, Meng Chen, et al. "Abstract 1186: microRNA-targeted small molecule inhibitors in metastatic cancers." Cancer Research 85, no. 8_Supplement_1 (2025): 1186. https://doi.org/10.1158/1538-7445.am2025-1186.

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Background: Gastric carcinoma is a highly heterogeneous disease with diverse subtypes, each with distinct histopathological and clinical characteristics, complicating prognosis and treatment. High mortality is driven by molecular and microenvironmental changes, often leading to peritoneal carcinomatosis. MicroRNAs (miRs), particularly miR-10b, play key roles in gastric cancer by promoting drug resistance, migration, and invasiveness. Targeting miR-10b with Small Molecule Inhibitors of miRNAs (SMIRs) offers a novel approach to disrupting RNA-small molecule interactions, presenting promising str

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Juwita, Juwita. "MICRORNA-21, MICRORNA-155 DAN MICRORNA-10B: BAGAIMANA PERANNYA PADA KANKER PAYUDARA?" Jurnal Kedokteran Syiah Kuala 17, no. 2 (2017): 119–25. http://dx.doi.org/10.24815/jks.v17i2.8991.

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Abstrak. Kanker payudara merupakan jenis kanker yang masih banyak diderita perempuan, baik di negara maju maupun berkembang. Perubahan genetik pada gen regulator utama menyebabkan perubahan ekspresi protein sehingga memicu terjadinya kanker. Saat ini diketahui bahwa microRNA berperan sebagai regulator utama gen manusia dan juga terlibat dalam karsinogenesis kanker payudara. MicroRNA-21 (miR-21), microRNA-155 (miR-155) dan microRNA-10b (miR-10b) merupakan oncogenic miRNA yang memicu perkembangan kanker payudara melalui inhibisi protein tumorsuppressor. Tinjauan ini membahas mengenai peran, gen

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Al-Mawlah, Yasir Haider, Asma’a H. Mohamed, Ali Mohammad Abd-Alameer, et al. "Assessment of the Specificity and Stability of Micro-RNAs as a Forensic Gene Marker." Biomedical and Biotechnology Research Journal (BBRJ) 7, no. 4 (2023): 569–76. http://dx.doi.org/10.4103/bbrj.bbrj_174_23.

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Abstract Background: Forensic investigations depend on bodily fluid analysis to identify the perpetrators. Identifying perpetrators requires knowledge about suspects’ body fluids. Due to their durability and tissue-specific expression patterns, miRNAs may be forensic indicators. However, miRNA expression patterns in various bodily fluids are seldom compared. This study examined miR-372, miR-135p, miR-124-3p, miR-16, and miR-10b expression in seminal fluids, blood stains, and vaginal secretions using quantitative PCR using SNORD-47 as a reference gene. This research compared miRNA expression le

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9

Zhang, Zhang, Shen, and Sun. "Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications." Cancers 12, no. 2 (2020): 341. http://dx.doi.org/10.3390/cancers12020341.

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Colorectal cancer (CRC) is one of the major causes of cancer death worldwide. In general, early diagnosis for CRC and individual therapy have led to better survival for the cancer patients. Accumulating studies concerning biomarkers have provided positive evidence to improve cancer early diagnosis and better therapy. It is, however, still necessary to further investigate the precise biomarkers for cancer early diagnosis and precision therapy and predicting prognosis. In this study, AI-assisted systems with bioinformatics algorithm integrated with microarray and RNA sequencing (RNA-seq) gene ex

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Yang, Rui-qi, Zhe-zhu Jin, San-ya Jiang, and Yong-jun Jin. "LncRNA GAS5 Interacts with MicroRNA-10b to Inhibit Cell Proliferation and Migration and Induces Apoptosis in Colorectal Cancer." Computational and Mathematical Methods in Medicine 2022 (January 22, 2022): 1–16. http://dx.doi.org/10.1155/2022/4996870.

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Objective. The purpose of this study was to study the effects of the GAS5/microRNA-10b (miR-10b) axis on proliferation, migration, and apoptosis of colorectal cancer (CRC). Methods. The expression levels of GAS5 and miR-10b in CRC tissues and cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Wound healing experiment was used to detect the effects of GAS5 and miR-10b on the migration of CRC cells. The luciferase reporter gene experiment was used to verify miRNA targets. Immunohistochemical assay was used to detect the expression of proteins related to metastasis

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Niedźwiecki, Sebastian, Janusz Piekarski, Bożena Szymańska, Zofia Pawłowska, and Arkadiusz Jeziorski. "Serum levels of circulating miRNA-21, miRNA-10b and miRNA-200c in triple-negative breast cancer patients." Ginekologia Polska 89, no. 8 (2018): 415–20. http://dx.doi.org/10.5603/gp.a2018.0071.

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Bechmann, Lars P., Diana Vetter, Junichi Ishida, et al. "Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis." Journal of Hepatology 58, no. 5 (2013): 1000–1006. https://doi.org/10.1016/j.jhep.2013.01.020.

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Background & Aims Dysregulated glucose homeostasis and lipid accumulation characterize non-alcoholic fatty liver disease (NAFLD), but underlying mechanisms are obscure. We report here that Krüppel-like factor 6 (KLF6), a ubiquitous transcription factor that promotes adipocyte differentiation, also provokes the metabolic abnormalities of NAFLD by post-transcriptionally activating PPARα-signaling. Methods Mice with either hepatocyte-specific depletion of KLF6 (‘ΔHepKlf6’) or global KLF6 heterozygosity (Klf6+/−) were fed a high fat diet (HFD) or chow for 8 or 16weeks. Glucose and insulin tole

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Zurlo, Matteo, Romeo Romagnoli, Paola Oliva, Jessica Gasparello, Alessia Finotti, and Roberto Gambari. "Synergistic Effects of A Combined Treatment of Glioblastoma U251 Cells with An Anti-miR-10b-5p Molecule and An AntiCancer Agent Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole Scaffold." International Journal of Molecular Sciences 23, no. 11 (2022): 5991. http://dx.doi.org/10.3390/ijms23115991.

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(1) Background: In the development of new and more effective anticancer approaches, combined treatments appear of great interest. Combination therapy could be of importance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer of the central nervous system, with a median survival of 15 months. This study aimed to verify the activity on a glioblastoma cancer cell line of one of the most active compounds of a novel series of tubulin polymerization inhibitors based on the 1-(3′,4′,5′-trimethoxyphenyl)-2-aryl-1H-imidazole scaffold, used in combination with a

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Abdal Rhida, Muna. "Investigating the MicroRNA 10b Regulatory Network: A Bioinformatic Approach to Transcription Factor Binding and Cancer Implications." Wasit Journal for Pure sciences 3, no. 3 (2024): 306–14. http://dx.doi.org/10.31185/wjps.514.

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miR-10b, that stands for microRNA 10 in bovine serum protein refers to a subgroup of small molecules belonging to the body especially involved in physiological processes with regard cancers initiation and progression as well cellular differentiation. An understanding of the regulation miR-10b along with identification of its corresponding transcription factors (TFs) that bind to the so-called mirR-10b Regulated-DNA Sequence (MRDS) as well discovering potential targets serves a powerful tool not only in elucidation but also pharmacological arsenal targeting miRNAs. In this work, two bioinformat

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LIANG, AI-LING, TING-TING ZHANG, NING ZHOU, CUI YUN WU, MAN-HUA LIN, and YONG-JUN LIU. "miRNA-10b sponge: An anti-breast cancer study in vitro." Oncology Reports 35, no. 4 (2016): 1950–58. http://dx.doi.org/10.3892/or.2016.4596.

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Siegal, Tali, Hanna Charbit, Iddo Paldor, et al. "Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab." Journal of Neurosurgery 125, no. 4 (2016): 1008–15. http://dx.doi.org/10.3171/2015.8.jns15437.

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OBJECTIVE Bevacizumab is an antiangiogenic agent under investigation for use in patients with high-grade glioma. It produces a high rate of radiological response; however, this response should be interpreted with caution because it may reflect normalization of the tumor vasculature and not necessarily a true antitumor effect. The authors previously demonstrated that 4 hypoxia-mediated microRNAs (miRNA)—miR-210, miR-21, miR-10b, and miR-196b—are upregulated in glioma as compared with normal brain tissue. The authors hypothesized that the regulation and expression of these miRNAs would be altere

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Grimaldi, Anna Maria, Roberta D’Assante, Francesco Fiore, et al. "Circulating miR-10b-5p, miR-193a-3p, and miR-1-3p Are Deregulated in Patients with Heart Failure and Correlate with Hormonal Deficiencies." International Journal of Molecular Sciences 26, no. 11 (2025): 5225. https://doi.org/10.3390/ijms26115225.

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Heart failure (HF) is among the most important causes of worldwide morbidity, hospitalisation, and mortality. A reduction in anabolic hormonal axes seems to potentially play an important role in chronic HF progression and prognosis. Several lines of evidence support the critical roles of miRNAs in the endocrine system, and differentially expressed miRNA patterns were found to be able to detect HF. To date, the ability of miRNAs to detect HF patients affected by hormonal deficiencies has yet to be addressed. The aim of this study was to explore the association between circulating miRNA profiles

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Stepanović, Aleksandar, Marina Nikitović, Tatjana P. Stanojković, et al. "Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide." Sci Rep 12, no. 1 (2022): 7505. https://doi.org/10.1038/s41598-022-11445-9.

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A personalized approach to chemoradiation is important in reducing its potential side effects and identifying a group of patients prone to toxicity. MicroRNAs have been shown to have a predictive potential for radiotoxicity. The goal of the study was to test if levels of miRNA in peripheral blood mononuclear cells of glioblastoma patients are associated with toxicity and to identify the peak time point for toxicity. MicroRNA-10b/21/34a levels were measured in 43 patients with and without toxicity, at baseline, at the 15th, and at the 30th fraction by Real-Time quantitative Polymerase Chain Rea

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Ru, Qin, Wei-ling Li, Qi Xiong, Lin Chen, Xiang Tian, and Chao-Ying Li. "Voltage-gated potassium channel blocker 4-aminopyridine induces glioma cell apoptosis by reducing expression of microRNA-10b-5p." Molecular Biology of the Cell 29, no. 9 (2018): 1125–36. http://dx.doi.org/10.1091/mbc.e17-02-0120.

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Accumulating evidence has demonstrated that voltage-gated potassium channels (Kv channels) were associated with regulating cell proliferation and apoptosis in tumor cells. Our previous study proved that the Kv channel blocker 4-aminopyridine (4-AP) could inhibit cell proliferation and induce apoptosis in glioma. However, the precise mechanisms were not clear yet. MicroRNAs (miRNAs) are small noncoding RNAs that act as key mediators in the progression of tumor, so the aim of this study was to investigate the role of miRNAs in the apoptosis-promoting effect of 4-AP in glioma cells. Using a micro

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Roman-Canal, Berta, Cristian Pablo Moiola, Sònia Gatius, et al. "EV-Associated miRNAs from Peritoneal Lavage are a Source of Biomarkers in Endometrial Cancer." Cancers 11, no. 6 (2019): 839. http://dx.doi.org/10.3390/cancers11060839.

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Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is responsible for more than 89,000 deaths every year. Mortality is associated with presence of poor prognostic factors at diagnosis, i.e., diagnosis at an advanced stage, with a high grade and/or an aggressive histology. Development of novel approaches that would permit us to improve the clinical management of EC patients is an unmet need. In this study, we investigate a novel approach to identify highly sensitive and specific biomarkers of EC using extracellular vesicles (EVs) isolated from the peritoneal lavage o

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Papadaki, Chara, Konstantina Thomopoulou, Alexia Monastirioti, et al. "MicroRNAs Regulating Tumor and Immune Cell Interactions in the Prediction of Relapse in Early Stage Breast Cancer." Biomedicines 9, no. 4 (2021): 421. http://dx.doi.org/10.3390/biomedicines9040421.

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MicroRNAs (miRNAs) are involved in the regulation of immune response and hold an important role in tumor immune escape. We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients’ relapse. Blood samples were obtained from healthy women (n = 20) and patients with early stage breast cancer (n = 140) before adjuvant chemotherapy. Plasma miRNA expression levels were assessed by RT-qPCR. Relapse predicting model

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Szczepanek, Joanna, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Cezary Cybulski, and Andrzej Tretyn. "Harnessing Epigenetics for Breast Cancer Therapy: The Role of DNA Methylation, Histone Modifications, and MicroRNA." International Journal of Molecular Sciences 24, no. 8 (2023): 7235. http://dx.doi.org/10.3390/ijms24087235.

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Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer development and progression, and epigenetic-targeting drugs such as DNA methyltransferase inhibitors, histone-modifying enzymes, and mRNA regulators (such as miRNA mimics and antagomiRs) can reverse these alterations. Therefore, these epigenetic-targeting drugs are promising candidates for cancer treatment. However, there is currently no effective epi-drug monotherapy for breast cancer. Combining epigenetic drugs

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Lin, X., E. Beckers, S. Mc Cafferty, et al. "63 Bovine embryo-secreted microRNA-30c negatively regulates cell cycle progression through downregulation of CDK12." Reproduction, Fertility and Development 31, no. 1 (2019): 157. http://dx.doi.org/10.1071/rdv31n1ab63.

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Identifying microRNA (miRNA) differentially secreted by intermediate (cleaved between 26.6-31.4 hpi) and slow cleaving bovine embryos (cleaved after 31.4 hpi), investigating how they influence embryo development and consequently if they can be used as biomarkers for bovine embryo development. MicroRNA collected from conditioned media (CM) of 167 individually cultured embryos were sequenced on an Illumina Miseq (Illumina, San Diego, CA, USA) after small RNA library construction with the Tailormix v2 kit (SeqMatic, Fremont, CA, USA) and compared with miRBase, using cow as primary organism, to id

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Khela, Harmon, Sweta Sudhir, Maria Lugo-Fagundo, Bachchu Lal, Hernando Lopez-Bertoni, and John Laterra. "STEM-27. miR-10b-5p MODULATES 5hmC EXPRESSION AND THE STEM-LIKE PHENOTYPE IN GBM." Neuro-Oncology 22, Supplement_2 (2020): ii202. http://dx.doi.org/10.1093/neuonc/noaa215.844.

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Abstract Epigenetic alterations such as DNA methylation and dysregulation of non-coding RNAs (e.g. miRNAs) are found in all types of cancer and are thought to play important roles in tumorigenesis. GBM is characterized by small subsets of cells, referred to as glioma stem cells (GSCs), that display stem-like properties implicated in tumor initiation, therapeutic resistance, and recurrence. DNA methylation patterns are altered in GBM and GSCs and are thought to play critical roles in tumor initiation and propagation. DNA methylation is a reversible process catalyzed, in part, by the ten-eleven

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Torrado, Mario, Diego Franco, Estefanía Lozano-Velasco, et al. "A MicroRNA-Transcription Factor Blueprint for Early Atrial Arrhythmogenic Remodeling." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/263151.

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Spontaneous self-terminating atrial fibrillation (AF) is one of the most common heart rhythm disorders, yet the regulatory molecular mechanisms underlying this syndrome are rather unclear. MicroRNA (miRNA) transcriptome and expression of candidate transcription factors (TFs) with potential roles in arrhythmogenesis, such asPitx2,Tbx5, and myocardin (Myocd), were analyzed by microarray, qRT-PCR, and Western blotting in left atrial (LA) samples from pigs with transitory AF established by right atrial tachypacing. Induced ectopic tachyarrhythmia caused rapid and substantial miRNA remodeling assoc

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Veryaskina, Yuliya A., Sergei E. Titov, Igor B. Kovynev, et al. "MicroRNAs in Diffuse Large B-Cell Lymphoma (DLBCL): Biomarkers with Prognostic Potential." Cancers 17, no. 8 (2025): 1300. https://doi.org/10.3390/cancers17081300.

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Background/Objectives: The heterogeneity of diffuse large B-cell lymphoma (DLBCL) based on differences in both genetic and epigenetic factors contributes to the dynamics of tumor growth and efficacy of cytoreductive therapy, as well as considerably affecting disease prognosis. This study aimed to detect microRNAs (miRNAs) capable of improving prognostic accuracy in DLBCL patients. Methods: We performed miRNA sequencing in bone marrow (BM) samples collected from DLBCL patients. Next, the expression levels of miRNAs in lymph node (LN) samples (n = 43) and BM samples (n = 70) were analyzed by rea

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Su, Wen-Hsiu (Vivian), Ciniso Sylvester Shabangu, and Shu-Chi Wang. "Abstract 3402: Integration of microRNAs and transcriptome signatures identifies the persistent infection of hepatitis C virus-induced hepatocellular carcinoma." Cancer Research 84, no. 6_Supplement (2024): 3402. http://dx.doi.org/10.1158/1538-7445.am2024-3402.

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Abstract MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs) of ~22 nucleotides that mediate gene expression through various functions, including gene silencing, which can lead to translation repression and degradation of target mRNAs. Dysregulation of miRNA function has been associated with numerous diseases, particularly cancer, including hepatocellular carcinoma (HCC). During the progression of HCV-HCC, the function of miRNAs may be altered thereby altering gene expression to favor HCC. Therefore, the involved miRNA-mRNA interaction needs to be further studied. In addition, there are many

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Nie, Kunhan, Yongjian Jiang, Na Wang, et al. "Programmable, Universal DNAzyme Amplifier Supporting Pancreatic Cancer-Related miRNAs Detection." Chemosensors 10, no. 7 (2022): 276. http://dx.doi.org/10.3390/chemosensors10070276.

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The abnormal expression of miRNA is closely related to the occurrence of pancreatic cancer. Herein, a programmable DNAzyme amplifier for the universal detection of pancreatic cancer-related miRNAs was proposed based on its programmability through the rational design of sequences. The fluorescence signal recovery of the DNAzyme amplifier showed a good linear relationship with the concentration of miR-10b in the range of 10–60 nM, with a detection limit of 893 pM. At the same time, this method displayed a high selectivity for miR-10b, with a remarkable discrimination of a single nucleotide diffe

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Da Cruz, Raquel Santana, Odalys Dominguez, Apsra Nasir, et al. "Abstract 1429: DDT induces intergenerational epigenetic inheritance of cancer predisposition in a mouse model." Cancer Research 82, no. 12_Supplement (2022): 1429. http://dx.doi.org/10.1158/1538-7445.am2022-1429.

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Abstract DNA sequence accounts for the majority of disease heritability, including cancer. Yet, not all familial cancer cases can be explained by genetic factors. There is mounting evidence that environmentally-induced epigenetic inheritance occurs and that the progeny’s traits can be shaped by parental environmental experiences. In humans, epidemiologic studies have implicated endocrine disruptors and environmental toxicants such as the pesticide DDT in intergenerational cancer development, including breast and childhood tumors. Using a mouse model, we investigated whether paternal DDT exposu

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Chen, Weijie, Fengfeng Cai, Bei Zhang, Zeinab Barekati, and Xiao Yan Zhong. "The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers." Tumor Biology 34, no. 1 (2012): 455–62. http://dx.doi.org/10.1007/s13277-012-0570-5.

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Medarova, Zdravka, Neil Robertson, Subrata Ghosh, Andreas Varkaris, Peter Caravan, and Susan Duggan. "Abstract PO5-27-06: Development of TTX-MC138, a First-In-Class miRNA-10b-Targeted Therapeutic Against Metastatic Cancers of Diverse Primary Disease Origins." Cancer Research 84, no. 9_Supplement (2024): PO5–27–06—PO5–27–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-27-06.

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Abstract Conventional therapies targeted towards the primary tumor cell oftentimes do not affect the metastatic cell and, in fact, may promote metastasis. For these reasons, our research has focused on developing therapies specific to unique properties of metastatic tumor cells. In our earlier work, we identified miRNA-10b as a master regulator of the viability of metastatic tumor cells. We determined that miRNA-10b not only promotes the capacity of tumor cells to migrate and invade surrounding tissue, but, importantly, serves as a powerful master regulator of the viability of cancer cells. Th

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Quan, Suyu, Xuemei Nan, Kun Wang, Linshu Jiang, Junhu Yao, and Benhai Xiong. "Characterization of Sheep Milk Extracellular Vesicle-miRNA by Sequencing and Comparison with Cow Milk." Animals 10, no. 2 (2020): 331. http://dx.doi.org/10.3390/ani10020331.

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Milk can mediate maternal-neonatal signal transmission by the bioactive component extracellular vesicles (EVs), which select specific types of miRNA to encapsulate. The miRNA profiling of sheep milk EVs was characterized by sequencing and compared with that of cow milk. Nanoparticle tracking analysis revealed that the concentration of sheep milk EVs was 1.3 ± 0.09 × 1012 particles/mL and the diameter was peaked at 131.2 ± 0.84 nm. Sheep milk EVs contained various small RNAs, including tRNA, Cis-regulatory element, rRNA, snRNA, other Rfam RNA, and miRNA, which held about 36% of all the small RN

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Huang, Jieping, Shuzhe Wang, Xue Feng, et al. "miRNA transcriptome comparison between muscle and adipose tissues indicates potential miRNAs associated with intramuscular fat in Chinese swamp buffalo." Genome 62, no. 11 (2019): 729–38. http://dx.doi.org/10.1139/gen-2018-0178.

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The amount of intramuscular fat (IMF) affects the tenderness and juiciness of beef and is an important indicator of beef quality. A few miRNAs involved in IMF deposition have been identified in other livestock. However, in the buffalo, the association between miRNA and IMF has not been reported and the miRNA expression profile remains poorly understood. In this study, small RNA sequencing was performed to characterize the miRNA expression pattern in muscle and adipose tissues using the Illumina platform. A total of 108 differentially expressed (DE) miRNAs were identified, including 98 known mi

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Hansen, Lexi, Sanket Naresh Nagdeve, Baviththira Suganthan, and Ramaraja P. Ramasamy. "An Electrochemical Nucleic Acid Biosensor for Triple-Negative Breast Cancer Biomarker Detection." Sensors 24, no. 17 (2024): 5747. http://dx.doi.org/10.3390/s24175747.

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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, affecting younger women and women of minorities. The nomenclature “triple negative” is derived from the absence of the three most common breast cancer biomarkers: progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2). It derives its name from testing negative for these three most common breast cancer biomarkers. Currently, TNBC is diagnosed at advanced stages, necessitating the need for a diagnostic tool or method to identify this malignancy at an early stage

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Timoshkina, Natalya N., Denis S. Kutilin, Inna A. Novikova, et al. "Features of iso-miR expression in colon tumor tissue." Journal of Clinical Oncology 38, no. 15_suppl (2020): e13518-e13518. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13518.

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e13518 Background: With the advent of deep sequencing, enormous variability in miRNA biogenesis was detected, which means that many different sequences can potentially be generated from the same miRNA precursor, potentially having different targets and opposite changes in expression. These variable forms of micro-RNA that differ from the reference sequence are called iso-miR. To date, features of iso-miR expression have not been studied in patients with colorectal cancer (CRC). The aim of the study was to analyze the differential expression of iso-miR in the tumor and normal tissues of patient

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Zhang, Wenjing, Yu Zhang, Yong Zhang, et al. "Methylation-Dependent Epigenetic Silencing Of Mir-152 and Mir-10b-5p Plays a Crucial Role In Modulating Tumor Progression In Multiple Myeloma." Blood 122, no. 21 (2013): 3751. http://dx.doi.org/10.1182/blood.v122.21.3751.3751.

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Abstract Background Epigenetic modifications including changes in DNA methylation lead to inhibited gene expressions and consequent phenotypic alterations. MicroRNAs (miRNAs) are a class of small non-coding RNAs (19∼25 nucleotides) which functions as endogenous silencers of target genes. In general, most miRNAs are downregulated in many cancers and specifically in multiple myeloma (MM). We hypothesized that the mechanism of low expression of tumor suppressor miRNAs in MM is through epigenetic silencing, specifically through CpG island hypermethylation. The aim of this study is to identify meth

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Mar-Aguilar, Fermín, Jorge A. Mendoza-Ramírez, Ismael Malagón-Santiago, et al. "Serum Circulating microRNA Profiling for Identification of Potential Breast Cancer Biomarkers." Disease Markers 34, no. 3 (2013): 163–69. http://dx.doi.org/10.1155/2013/259454.

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MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different diseases. We investigated whether quantitative RT-PCR miRNA profiling on serum could discriminate between breast cancer patients and healthy controls. We performed miRNA profiling on serum from breast cancer patients, followed by construction of ROC (Receiver Operating Characteri

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Lv, Xiaoyang, Weihao Chen, Shanhe Wang, et al. "Integrated Hair Follicle Profiles of microRNAs and mRNAs to Reveal the Pattern Formation of Hu Sheep Lambskin." Genes 13, no. 2 (2022): 342. http://dx.doi.org/10.3390/genes13020342.

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Hair follicle development is closely associated with wool curvature. Current studies reveal the crucial role of microRNAs (miRNAs) in hair follicle growth and development. However, few studies are known regarding their role in wool curvature. To reveal the potential roles of miRNAs in Hu sheep lambskin with different patterns, a total of 37 differentially expressed (DE) miRNAs were identified in hair follicles between small waves (SM) and straight wool (ST) groups using RNA-seq. Through functional enrichment and miRNA-mRNA co-expression analysis, some key miRNAs (oar-miR-143, oar-miR-200b, oar

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Majewska, Aleksandra, Klaudia Brodaczewska, Aleksandra Filipiak-Duliban, Arkadiusz Kajdasz, and Claudine Kieda. "miRNA Pattern in Hypoxic Microenvironment of Kidney Cancer—Role of PTEN." Biomolecules 12, no. 5 (2022): 686. http://dx.doi.org/10.3390/biom12050686.

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MicroRNAs are post-transcriptional regulators of gene expression, and disturbances of their expression are the basis of many pathological states, including cancers. The miRNA pattern in the context of tumor microenvironment explains mechanisms related to cancer progression and provides a potential target of modern therapies. Here we show the miRNA pattern in renal cancer focusing on hypoxia as a characteristic feature of the tumor microenvironment and dysregulation of PTEN, being a major tumor suppressor. Methods comprised the CRSPR/Cas9 mediated PTEN knockout in the Renca kidney cancer cell l

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Papadaki, Chara, Konstantina Thomopoulou, George Koronakis, et al. "MicroRNAs involved in immune response as prognostic markers in early and metastatic breast cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15528-e15528. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15528.

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e15528 Background: MicroRNAs (miRNAs) are involved in the regulation of immune response and have an important role in immune escape. We analyzed the expression levels of plasma miR-10b, miR-126, miR-19α, miR-20α and miR-155, which regulate tumor-immune interactions and investigated their prognostic implications in patients with early (eBC) and metastatic (mBC) breast cancer. Methods: Blood samples were obtained before treatment from 140 and 64 patients with eBC and mBC, respectively. Plasma miRNA expression levels were assessed by qRT-PCR and expression was classified as high or low according

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Kim, Min Woo, Hani Koh, Jee Ye Kim, et al. "Tumor-Specific miRNA Signatures in Combination with CA19-9 for Liquid Biopsy-Based Detection of PDAC." International Journal of Molecular Sciences 22, no. 24 (2021): 13621. http://dx.doi.org/10.3390/ijms222413621.

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Pancreatic ductal adenocarcinoma (PDAC) is considered one of the most aggressive malignancies and has high mortality and poor survival rates. Therefore, there is an urgent need to discover non-invasive biomarkers for early detection before PDAC reaches the incurable stage. We hypothesized that liquid biopsy of PDAC-derived extracellular vesicles (PDEs) containing abundant microRNAs (miRNAs) could be used for early diagnosis of PDAC because they can be selectively enriched and because they are biologically stable. We isolated PDEs by immunocapture using magnetic beads, and we identified 13 miRN

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Pawlina-Tyszko, Klaudia, Ewelina Semik-Gurgul, Tomasz Ząbek, and Maciej Witkowski. "Methylation Status of Gene Bodies of Selected microRNA Genes Associated with Neoplastic Transformation in Equine Sarcoids." Cells 11, no. 12 (2022): 1917. http://dx.doi.org/10.3390/cells11121917.

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Horses are of great importance in recreation, livestock production, as working animals in poorly developed countries, and for equine-assisted therapy. Equine sarcoids belong to the most commonly diagnosed tumors in this species. They may cause discomfort, pain, and can lead to the permanent impairment of motor function. The molecular bases of their formation are still under investigation. Our previous studies revealed altered microRNA (miRNA) expression and DNA methylation levels in sarcoid tumors. Abnormal patterns of methylation may be responsible for changes in gene expression levels, inclu

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Bjarnason, Georg A., Nicole MA White, Heba WZ Khella, et al. "Tumor suppressor effects for miR-215 identified through use of miRNA profiling in metastatic renal cell carcinoma." Journal of Clinical Oncology 30, no. 5_suppl (2012): 392. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.392.

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392 Background: Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. Metastatic RCC is difficult to treat. The five-year survival rate for metastatic RCC is <10%. Recently, microRNAs (miRNAs) have been shown to have a role in cancer metastasis and potential as prognostic biomarkers in cancer. Methods: We preformed a miRNA microarray to identify a miRNA signature characteristic of metastatic compared to primary RCC. Results were validated by quantitative real time PCR. Target prediction analysis and gene expression profiling identified many of the dysregulated miRNAs c

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Yousef, George M., Susanne M. Chan, Nicole MA White, et al. "Use of miRNA profiling in metastatic renal cell carcinoma to reveal a tumor suppressor effect for mir-215." Journal of Clinical Oncology 30, no. 15_suppl (2012): 4633. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4633.

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4633 Background: Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. Metastatic RCC is difficult to treat. The five-year survival rate for metastatic RCC is <10%. Recently, microRNAs (miRNAs) have been shown to have a role in cancer metastasis and potential as prognostic biomarkers in cancer. Methods: We performed a miRNA microarray to identify a miRNA signature characteristic of metastatic compared to primary RCC. Results were validated by quantitative real time PCR. Target prediction analysis and gene expression profiling identified many of the dysregulated miRNAs

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Wang, Dongliang, Min Xia, Xiao Yan, et al. "Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b." Circulation Research 111, no. 8 (2012): 967–81. http://dx.doi.org/10.1161/circresaha.112.266502.

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Du, Gang, Chongren Ren, Ju Wang, and Jun Ma. "The Clinical Value of Blood miR-654-5p, miR-126, miR-10b, and miR-144 in the Diagnosis of Colorectal Cancer." Computational and Mathematical Methods in Medicine 2022 (October 13, 2022): 1–8. http://dx.doi.org/10.1155/2022/8225966.

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Colorectal cancer (CRC) is the third cause of cancer-related death and the fourth most frequently diagnosed cancer across the globe. The objective of this study is to obtain novel and effective diagnostic markers to enrich CRC diagnosis methods. Herein, exosomal miRNA expression data of CRC and normal blood were subjected to XGBoost algorithm, and 5 miRNAs related to CRC diagnosis were primarily confirmed. Then multilayer perceptron (MLP) classifiers were constructed based on different subsets. Via integrated feature selection (IFS), we noticed that the MLP classifier constructed by the first

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Medarova, Zdravka, Neil Robertson, Subrata Ghosh, et al. "Abstract P3-08-29: Early Clinical Experience with TTX-MC138, a First-in-Class Therapeutic Candidate for Metastatic Breast Cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–08–29—P3–08–29. https://doi.org/10.1158/1557-3265.sabcs24-p3-08-29.

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Abstract For the past 20 years our research has specifically focused on developing potential therapies targeting specific properties of tumor cells that have metastasized. Although the mechanisms and triggers of metastasis are not completely understood, cancer cells exhibit the ability to break out of the primary tumor mass, travel through the circulation, and colonize a new vital organ in the process of metastasis. Of therapeutic significance, these metastatic cells are genetically and phenotypically distinct from the majority of the cells in the tumor mass serving to limit the effectiveness

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Chen, Yongxin, Jonathan Gelfond, Linda M. McManus, and Paula K. Shireman. "Temporal microRNA expression during in vitro myogenic progenitor cell proliferation and differentiation: regulation of proliferation by miR-682." Physiological Genomics 43, no. 10 (2011): 621–30. http://dx.doi.org/10.1152/physiolgenomics.00136.2010.

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MicroRNAs (miRNAs) regulate gene expression by repressing target genes at the posttranscriptional level. Since miRNAs have unique expression profiles in different tissues, they provide pivotal regulation of many biological processes. The present study defined miRNA expression during murine myogenic progenitor cell (MPC) proliferation and differentiation to identify miRNAs involved in muscle regeneration. Muscle-related gene expression analyses revealed that the time course and expression of myosin heavy chain (MHC) and transcription factors (Myf5, MyoD, myogenin, and Pax7) were similar during

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Kopkova, Alena, Jiri Sana, Tana Machackova, et al. "Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain Tumors." Cancers 11, no. 10 (2019): 1546. http://dx.doi.org/10.3390/cancers11101546.

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Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as well as secondary tumors that develop as a result of metastatic spread. Circulating microRNAs (miRNAs) were found in almost all human body fluids including cerebrospinal fluid (CSF), and they seem to be highly stable and resistant to even extreme conditions. The overall aim of our study was to identify specific CSF miRNA patterns that could differentiate among brain tumors. These new biomarkers could potentially aid borderline or uncertain imaging results onto diagnosis of CNS malignancies, avoidi

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Bestavros, Samantha, Darshini Ganatra, Anas Samman, et al. "Validating Differentially Expressed Micro-RNAs That Distinguish Psoriatic Arthritis from Osteoarthritis." Journal of Rheumatology 52, Suppl 2 (2025): 37.1–37. https://doi.org/10.3899/jrheum.2025-0314.tour7b.

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ObjectivesBiomarkers may help differentiate psoriatic arthritis (PsA) from osteoarthritis (OA). MicroRNAs have potential to be robust biomarkers, we aimed to 1) Use miRNA sequencing to analyze miRNA expression profiles in the synovial fluid of patients with PsA compared to those with OA, 2) Validate differential expression of select miRNAs in an independent cohort of PsA and OA patients through quantitative real-time PCR (qRT-PCR), and 3) Investigate the potential for differentially expressed miRNAs between PsA and OA to serve as biomarkers for PsA to enhance PsA diagnostic accuracy.MethodsWe

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