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1

Iqbal, Md Ashik, Ye Wang, Md Mamun Miah, and Mohamed S. Osman. "Study on Date–Jimbo–Kashiwara–Miwa Equation with Conformable Derivative Dependent on Time Parameter to Find the Exact Dynamic Wave Solutions." Fractal and Fractional 6, no. 1 (2021): 4. http://dx.doi.org/10.3390/fractalfract6010004.

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In this article, we construct the exact dynamical wave solutions to the Date–Jimbo–Kashiwara–Miwa equation with conformable derivative by using an efficient and well-established approach, namely: the two-variable G’/G, 1/G-expansion method. The solutions of the Date–Jimbo–Kashiwara–Miwa equation with conformable derivative play a vital role in many scientific occurrences. The regular dynamical wave solutions of the abovementioned equation imply three different fundamental functions, which are the trigonometric function, the hyperbolic function, and the rational function. These solutions are cl
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Al-Sawalha, M. Mossa, Saima Noor, Mohammad Alqudah, Musaad S. Aldhabani, and Roman Ullah. "Dynamics of the Traveling Wave Solutions of Fractional Date–Jimbo–Kashiwara–Miwa Equation via Riccati–Bernoulli Sub-ODE Method through Bäcklund Transformation." Fractal and Fractional 8, no. 9 (2024): 497. http://dx.doi.org/10.3390/fractalfract8090497.

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The dynamical wave solutions of the time–space fractional Date–Jimbo–Kashiwara–Miwa (DJKM) equation have been obtained in this article using an innovative and efficient technique including the Riccati–Bernoulli sub-ODE method through Bäcklund transformation. Fractional-order derivatives enter into play for their novel contribution to the enhancement of the characterization of dynamic waves while providing better modeling ability compared to integer types of derivatives. The solutions of the above-mentioned time–space fractional Date–Jimbo–Kashiwara–Miwa equation have tremendous importance in n
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3

Its, A. R., and A. Prokhorov. "On Some Hamiltonian Properties of the Isomonodromic Tau Functions." Reviews in Mathematical Physics 30, no. 07 (2018): 1840008. http://dx.doi.org/10.1142/s0129055x18400081.

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We discuss some new aspects of the theory of the Jimbo–Miwa–Ueno tau function which have come to light within the recent developments in the global asymptotic analysis of the tau functions related to the Painlevé equations. Specifically, we show that up to the total differentials the logarithmic derivatives of the Painlevé tau functions coincide with the corresponding classical action differential. This fact simplifies considerably the evaluation of the constant factors in the asymptotics of tau functions, which has been a long-standing problem of the asymptotic theory of Painlevé equations. F
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4

Aubee, Joseph I., Kinlyn Williams, Alexandria Adigun, Olufolakemi Olusanya, and Karl M. Thompson. "31547 Regulation and function of the i6A37 tRNA modification." Journal of Clinical and Translational Science 5, s1 (2021): 2. http://dx.doi.org/10.1017/cts.2021.407.

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ABSTRACT IMPACT: MiaA has a human homolog known as TRIT1. Mutations in TRIT1 have been associated with rare diseases such as MELAS and MERRF syndromes. These diseases are associated with mitochondrial disfunction.Understanding the mechanisms of bacterial sRNAs, and the miRNAs associated with these diseases could potentially afford the insight into effective cures. OBJECTIVES/GOALS: The aim is to investigate the regulation and function of tRNA isopentyladenine transferase enzyme in Escherichia coli. We aimed to execute screens for the identification of small RNA regulators of MiaA. The study wi
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Aubee, Joseph I., Kinlyn Williams, Alexandria Adigun, Olufolakemi Olusanya, Jalisa Nurse, and Karl M. Thompson. "Post-Transcriptional Regulation of the MiaA Prenyl Transferase by CsrA and the Small RNA CsrB in Escherichia coli." International Journal of Molecular Sciences 26, no. 13 (2025): 6068. https://doi.org/10.3390/ijms26136068.

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MiaA is responsible for the addition of the isopentyl modification to adenine 37 in the anticodon stem loop of specific tRNAs in Escherichia coli. Mutants in miaA have pleotropic effects on the cell in E. coli and play a role in virulence gene regulation. In addition, MiaA is necessary for stress response gene expression by promoting efficient decoding of UUX-leucine codons, and genes with elevated UUX-leucine codons may be a regulatory target for i6A-modified tRNAs. Understanding the temporal nature of the i6A modification status of tRNAs would help us determine the regulatory potential of Mi
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6

Machuldova, Alena, Lucie Houdova, Katerina Kratochvilova, et al. "Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT." Journal of Clinical Medicine 10, no. 20 (2021): 4636. http://dx.doi.org/10.3390/jcm10204636.

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NKG2D and its ligands, MICA and MICB, are known as the key regulators of NK cells. NK cells are the first reconstituted cells after the allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT outcome. In the presented study, we investigated the single amino acid changes across the exons 2–4 of MICA and MICB genes, and point mutations within the NKG2D gene, which defines the type of NKG2D haploblock (HNK/LNK) in the donors (n = 124), as well as in patients with acute myeloid leukemia (n = 78). In our cohort, we found that graft from a
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7

Kravchenko, O. "MUSIC FOR THE PLAY OF MYKOLA KULISH "MINA MAZAYLO" BY IHOR HAYDENKO." Sciences of Europe, no. 115 (April 24, 2023): 3–5. https://doi.org/10.5281/zenodo.7857892.

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The article highlights some features of the musical and theatrical work of the modern Ukrainian artist, the representative of Kharkiv School of Composers, Ihor Haydenko. Music for theatrical productions plays an important place in the creative work of composer. He is attracted to music through words, gestures, and movement as its part. He considers his main creative task to be serving people with his art, to reproduce life's impressions, thoughts, feelings and bring them in emotional way to the listener. The dialogue between the author and the listeners is the priority task of the composer
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8

Djarwo, Catur Fathonah, Paul Johan Kawatu, Fridolin Nadap Yokhu, and Nadila Meylani Kirey Putri. "Analysis of Digital Literacy of MIPA and MIPA Education Students." Indonesian Journal of Contemporary Multidisciplinary Research 3, no. 2 (2024): 323–30. http://dx.doi.org/10.55927/modern.v3i2.8579.

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UNCEN Mathematics and Natural Sciences Education Department students are students who actively play a role in utilizing digital information sources. However, this raises problems regarding the use of digital sources. So because of the problems that often occur, it is not yet known whether students have utilized digital resources properly and correctly, so research needs to be conducted to find out more about what the digital literacy of students majoring in Mathematics and Natural Sciences Education is like in supporting learning using instant DCA (Digital Competence Assessment) measurements.
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9

Edgerton-Morgan, Heather, та Berl R. Oakley. "γ-Tubulin plays a key role in inactivating APC/CCdh1 at the G1–S boundary". Journal of Cell Biology 198, № 5 (2012): 785–91. http://dx.doi.org/10.1083/jcb.201203115.

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A γ-tubulin mutation in Aspergillus nidulans, mipA-D159, causes failure of inactivation of the anaphase-promoting complex/cyclosome (APC/C) in interphase, resulting in failure of cyclin B (CB) accumulation and removal of nuclei from the cell cycle. We have investigated the role of CdhA, the A. nidulans homologue of the APC/C activator protein Cdh1, in γ-tubulin–dependent inactivation of the APC/C. CdhA was not essential, but it targeted CB for destruction in G1, and APC/CCdhA had to be inactivated for the G1–S transition. mipA-D159 altered the localization pattern of CdhA, and deletion of the
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10

Crespo, O´Relly Nismel, Pardo Elen Dolores Álvarez, and Alonso Oslaidys Abreu. "La gestión del conocimiento en función del grupo para la atención a la dinámica demográfica." Estrategia y Gestión Universitaria 11, no. 1 (2023): 1–12. https://doi.org/10.5281/zenodo.11458891.

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<strong>Introducci&oacute;n:</strong> en el municipio Mor&oacute;n existen diversas problem&aacute;ticas relacionadas con la Gesti&oacute;n del Conocimiento en funci&oacute;n del Grupo para la Atenci&oacute;n a la Din&aacute;mica Demogr&aacute;fica. Sobre esta base se plante&oacute; la caracterizaci&oacute;n del municipio, lo cual permiti&oacute; perfeccionar su labor en funci&oacute;n de ofrecer la oportunidad de nuevos conocimientos para la gesti&oacute;n hacia el cambio de mentalidad, en correspondencia con las funciones que desarrollan. <strong>Objetivo:</strong> elaborar un plan de acci&o
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11

huo, zhi, Yizhou Zou, Fengping Hu, and Ping Yu. "Investigation of MICA*A5.1 Allele in Ankylosing Spondylitis (49.23)." Journal of Immunology 182, no. 1_Supplement (2009): 49.23. http://dx.doi.org/10.4049/jimmunol.182.supp.49.23.

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Abstract MICA (major histocompatibility complex class I chain-related genes A) is known to be associated with susceptibility to various autoimmune diseases. Recent studies have also demonstrated that MICA*A5.1, one allele of MICA, contributed to the resistance of microorganism infection. The aim of this study was to investigate the association between MICA*A5.1 allele and ankylosing spondylitis (AS). A total of 144 AS patients selected from south China and 110 ethnically matched unrelated healthy controls were typed for MICA*A5.1 polymorphism in addition to HLA-B27 typing by polymerase chain r
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12

Parmar, Simrit, Marcos del Lima, Yizhou Zou, et al. "Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease." Blood 114, no. 14 (2009): 2884–87. http://dx.doi.org/10.1182/blood-2009-05-223172.

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Abstract The polymorphic products of major histocompatibility complex class I–related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mi
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13

Wang, Qingwen, and Xiaodong Zhou. "Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases." Open Rheumatology Journal 9, no. 1 (2015): 94–100. http://dx.doi.org/10.2174/1874312901409010094.

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Inflammatory rheumatic diseases are characterized by inflammation resulting from the immune dysregulation that usually attacks joints, skin and internal organs. Many of them are considered as complex disease that may be predisposed by multiple genes and/or genetic loci, and triggered by environmental factors such as microbiome and cellular stress. The major histocompatibility complex class I chain-related gene A (MICA) is a highly polymorphic gene that encodes protein variants expressed under cellular stress conditions, and these MICA variants play important roles in immune activation and surv
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14

Rakasiwi, Audy Krisnandyaz, Sri Wahyuni, and Maria Yosephin W.L. "The Effectiveness of Using Role Play to Improve Speaking Skills for Students of Senior High School." Edusia: Jurnal Ilmiah Pendidikan Asia 4, no. 1 (2024): 14–26. https://doi.org/10.53754/edusia.v4i1.696.

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The following subjects were specifically investigated in this study; 1) To compare role play learning strategies and conventional models in improving students' English speaking skills. 2.) To find out why the role play learning strategy in improving students' english speaking skills can be said to be more effective. The design of this research is quasi-experimental using control and experimental classes. The method that will be used in the experimental class is the use of Role Play and the control method uses the conventional method. The sample that will be taken by the researcher is two class
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15

Neudys, María. "LA MODALIDAD DISCURSIVA Y LA EVIDENCIALIDAD. UNA PERSPECTIVA PARA ANALIZAR MATERIALES INSTRUCCIONALES." Aula Virtual (ISSN:2665-0398) 4, no. 10 (2023): 70–86. https://doi.org/10.5281/zenodo.8132692.

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El plan de curso forma parte del material instruccional utilizado en las asignaturas que componen la oferta acad&eacute;mica de la Universidad Nacional Abierta (UNA). El presente trabajo tiene como prop&oacute;sito hacer un estudio ling&uuml;&iacute;stico enmarcado en una investigaci&oacute;n de campo sobre el discurso acad&eacute;mico usado del plan de curso de la asignatura Lengua y Comunicaci&oacute;n, perteneciente al &Aacute;rea de Estudios Generales, tomando en consideraci&oacute;n la modalidad discursiva, los actos de habla y la evidencialidad (Otaola 1988; S&aacute;nchez 1995; L&oacute
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FILIPOVIĆ, ALEKSANDAR. "LIMITATIONS OF MASS MEDIA IN CREATING A CULTURE OF PEACE." Kultura polisa, (2021), special edition (2) (December 5, 2021): 91–104. http://dx.doi.org/10.51738/kpolisa2021.18.2p.1.07.

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The mass media, and the media in general, play an extremely important role in every society, as well as in people's daily lives. This role was crucial even before the number and type of media, and thus the way they work, were multiplied by digitalization and migration to online digital spaces. Today, we have a situation where a certain number of people prefer to be informed through social rather than traditional media, even about issues that affect life and health. With all this in mind, it is logical to think that the media can act for the purpose of achieving any proclaimed goal, and that th
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17

Taneja, Nilay, and Dylan T. Burnette. "Myosin IIA drives membrane bleb retraction." Molecular Biology of the Cell 30, no. 9 (2019): 1051–59. http://dx.doi.org/10.1091/mbc.e18-11-0752.

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Membrane blebs are specialized cellular protrusions that play diverse roles in processes such as cell division and cell migration. Blebbing can be divided into three distinct phases: bleb nucleation, bleb growth, and bleb retraction. Following nucleation and bleb growth, the actin cortex, comprising actin, cross-linking proteins, and nonmuscle myosin II (MII), begins to reassemble on the membrane. MII then drives the final phase, bleb retraction, which results in reintegration of the bleb into the cellular cortex. There are three MII paralogues with distinct biophysical properties expressed in
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Cotes, Daniel, Hernan Correa, Johan Ricardo, Enrique Soto, and Daniela Torres. "Plan de manejo ambiental de la mina Hornical en el municipio de Distracción, La Guajira." Revista Agunkuyâa 8, no. 1 (2018): 60–73. http://dx.doi.org/10.33132/27114260.1230.

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En el Departamento de La Guajira, tradicionalmente se ha desarrollado la extracción artesanal de la Caliza, en la mina ubicada en la jurisdicción del municipio de Distracción, más específicamente en corregimiento de Los Hornitos, que lleva ese nombre precisamente porque en el frente de las viviendas que comprenden esta localidad existe un “Horno” para la calcinación de este importante mineral. El objetivo general de este estudio es formular el plan de manejo ambiental de la mina Hornical en función de evaluación cuantitativa y cualitativa de los impactos ambientales identificados por el proyec
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Li, Xin, Hongzhang Dai, Shanbao Liu, et al. "Genesis of the Ke’eryin Two-Mica Monzogranite in the Ke’eryin Pegmatite-Type Lithium Ore Field, Songpan–Garze Orogenic Belt: Evidence from Lithium Isotopes." Minerals 14, no. 7 (2024): 687. http://dx.doi.org/10.3390/min14070687.

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Previous studies on the Ke’eryin pegmatite-type lithium ore field in the Songpan–Ganzi Orogenic Belt have explored the characteristics of the parent rock but have not precisely determined its magma source area. This uncertainty limits our understanding of the regularity of lithium ore formation in this region. In this study, to address the issue of the precise source area of the parent rock of lithium mineralization, a detailed analysis of the Li isotope composition of the ore-forming parent rock (Ke’eryin two-mica monzogranite) and its potential source rocks (Triassic Xikang Group metamorphic
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Bix, Mark, Shangli Lian та Meenu Pillai. "Host resistance to a gastrointestinal parasite regulated by a SNP modulating SMAD3 binding to a TGFβ-regulated transcriptional enhancer of Mina, encoding an immunoregulatory member of the Jmjc protein family (70.9)". Journal of Immunology 188, № 1_Supplement (2012): 70.9. http://dx.doi.org/10.4049/jimmunol.188.supp.70.9.

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Abstract In a hunt for Th2-bias regulatory loci in mice, we have used interval-specific congenic mapping to positionally clone a gene called Mina, encoding an immunoregulatory member of the JmjC protein family. Th2-bias is a genetic trait defined as the propensity of naïve T helper cells to develop in vitro under neutral conditions into T helper 2 (Th2) effector cells. Th2 cells play a critical role in host protection from multicellular parasites such as intestinal helminths and when disregulated contribute to allergic diseases such as asthma. The Th2-bias trait is known to vary across differ
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Ortiz, Milta. "Sanctuary." Departures in Critical Qualitative Research 9, no. 1 (2020): 116–23. http://dx.doi.org/10.1525/dcqr.2020.9.1.116.

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Sanctuary is a play based on real events and real people. In this opening scene, we meet Carol and Mica as they set out to investigate what they believe to be a refugee crisis in 1981. They have uncovered harsh truths about Central Americans, mostly Salvadorans, fleeing war. They are being detained by border patrol under the US Immigration and Naturalization Service's orders and are being coerced against political asylum applications. Mica and Carol set out to help refugees apply for political asylum, but first they must convince the detainees one by one that they can be trusted.
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Pereira-Macedo, Juliana, Beatriz Lopes-Fernandes, Luís Duarte-Gamas, et al. "The Gupta Perioperative Risk for Myocardial Infarct or Cardiac Arrest (MICA) Calculator as an Intraoperative Neurologic Deficit Predictor in Carotid Endarterectomy." Journal of Clinical Medicine 11, no. 21 (2022): 6367. http://dx.doi.org/10.3390/jcm11216367.

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Background: Patients undergoing carotid endarterectomy (CEA) may experiment intraoperative neurologic deficits (IND) during carotid cross-clamping. This work aimed to assess the impact of the Gupta Perioperative Myocardial Infarct or Cardiac Arrest (MICA) risk calculator in the IND. Methods: From January 2012 to April 2021, patients undergoing CEA with regional anaesthesia for carotid stenosis with IND and consecutively control operated patients without IND were selected. A regressive predictive model was created, and a receiver operating characteristic (ROC) curve was applied for comparison.
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Chen, Lihua, Jiuyu Gong, Liang Fang, and Boquan Jin. "Attenuated NK cell killing to hepatoma cells increases the mortality via decreased expression levels of MICA, CD112 and CD155 during UPR (P2023)." Journal of Immunology 190, no. 1_Supplement (2013): 53.12. http://dx.doi.org/10.4049/jimmunol.190.supp.53.12.

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Abstract Natural killer (NK) cells play important roles in anti-tumor immunity. Here, we demonstrate that the unfolded protein response (UPR) attenuated the sensitivity of hepatoma cells to NK cell cytotoxic activity by decreasing the expression levels of MHC class I-related chain A/B (MICA/B), CD112 and CD155 in human hepatocellular carcinoma (HCC) cells. The decreased expression levels of MICA/B, CD112 and CD155 were due to the involvement of the activating transcription factor 6 (ATF6) and inositol-requiring enzyme 1α (IRE1α) pathways. In addition, the IRE1α pathway contributed to the incre
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Panagiotakopoulos, Antonios. "Mina makes the most of human‐resource management." Human Resource Management International Digest 21, no. 1 (2013): 26–27. http://dx.doi.org/10.1108/09670731311296474.

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PurposeThe purpose of this paper is to describe how strategic human resource management has transformed the fortunes of three Greek micro‐enterprises.Design/methodology/approachThe paper explains the problems faced by Mina mini‐market, Franco leather manufacturing and Yiannis Hair Care, and how they overcame them.FindingsThe paper highlights the key role that training can play in improving product quality and customer service and setting a struggling company back on the track to success.Practical implicationsThe paper reveals that training can go hand in hand with new bonus schemes, employee e
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Podlešáková, Kateřina, Joel Fardoux, Delphine Patrel, et al. "Rhizobial Synthesized Cytokinins Contribute to But Are Not Essential for the Symbiotic Interaction Between Photosynthetic Bradyrhizobia and Aeschynomene Legumes." Molecular Plant-Microbe Interactions® 26, no. 10 (2013): 1232–38. http://dx.doi.org/10.1094/mpmi-03-13-0076-r.

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Cytokinins (CK) play an important role in the formation of nitrogen-fixing root nodules. It has been known for years that rhizobia secrete CK in the extracellular medium but whether they play a role in nodule formation is not known. We have examined this question using the photosynthetic Bradyrhizobium sp. strain ORS285 which is able to nodulate Aeschynomene afraspera and A. indica using a Nod-dependent or Nod-independent symbiotic process, respectively. CK profiling showed that the most abundant CK secreted by Bradyrhizobium sp. strain ORS285 are the 2MeS (2-methylthiol) derivatives of trans-
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Navàs, Marina. "La saviesa, una mica més òrfena: plany a Josep M. Pujol (1947-2012)." Mot so razo 12 (February 1, 2013): 67. http://dx.doi.org/10.33115/udg_bib/msr.v12i0.1499.

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Mulyani, Renita Sri, and Supardi Supardi. "Penggunaan Model Pembelajaran Role Play untuk Meningkatkan Prestasi Belajar Mata Pelajaran Matematika." PANDITA : Interdisciplinary Journal of Public Affairs 6, no. 1 (2023): 46–60. http://dx.doi.org/10.61332/ijpa.v6i1.68.

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Berdasarkan pada rendahnya nilai hasil evaluasi mata pelajaran Matematika perlu dilakukan suatu tinjauan yang seksama agar pembelajaran ini dapat mencapai hasilyang maksimal. Seperti kurangnya model pembelajaran yang digunakan pada saat proses pembelajaran berlangsung,sehingga membuat siswa mengalami kecenderungan belajar yang pasif. Dengan demikian akan berpengaruh terhadap hasil belajar dan prestasi belajar yang diperoleh masing-masing siswa. Untuk mengatasi permasalahan tersebut diperlukan cara efektif dalam memilih model pembelajaran seperti model pembelajaran Role Plya. Model pembelajaran
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Corrius, Montse, Eva Espasa, and Laura Santamaria. "Translating Multilingualism in Mira Nair’s Monsoon Wedding." Languages 8, no. 2 (2023): 129. http://dx.doi.org/10.3390/languages8020129.

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Linguistic diversity is present in many audiovisual productions and has given rise to fruitful research on translation of multilingualism and language variation. Monsoon Wedding (Mira Nair, 2001) is a prototypical film for translation analysis, since multilingualism is a recurrent feature, as the film dialogue combines English (L1) with Hindi and Punjabi (L3), which creates an effect of code-switching. This article analyses how the multilingualism and the cultural elements present in the source text (ST) have been transferred to the Spanish translated text (TT) La boda del monzón. The results
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DOVBNYA, K. "Types of poetry figures (shabdalankar) of Mira Bai's poetry." Bulletin of Taras Shevchenko National University of Kyiv. Oriental Languages and Literatures, no. 26 (2020): 55–57. http://dx.doi.org/10.17721/1728-242x.2020.26.55-57.

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This article addresses the issue of the types of poetic figures (shabdalankar) in the poetry of the famous poetess of the medieval socio-religious movement bhakti Mira Bai, namely, an important category of Hindi poetry – alankars, which help to express aesthetic emotion – racu. Therefore, their study is of great importance for characterizing the work of Mira Bai in general. Alankars are usually called rhetorical figures, and their close translation – "decorations" – corresponds to the most important European rhetorical category fully, which covers the concept of figures and paths ornatus. They
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Tomić, Marija. "Transposition of the myth of Pan's flute in Satirova svirala [La flûte de Pan] by Petar Konjović: Fantasy and ballad aspects." New Sound, no. 58-2 (2021): 19–38. http://dx.doi.org/10.5937/newso2157019t.

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In this paper we interpret the elements of the fantasy and ballad principle in Satirova svirala [La flûte de Pan] (1945) for solo flute written by Petar Konjović (1883-1970) from the point of view of the author's poetics and musical and non-musical analogies with Claude Debussy's (1862-1918) composition Syrinx (1913). Aspects of the fantasy principle are equally manifested when considering Satirova svirala as a unique musical entity that musicalizes the myth of Pan's flute, as well as in the context of its dramaturgical position, as being the central movement (Andante più sostenuto e molto rub
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Whalen, Kerry A., Naveen K. Mehta, Safak Yalcin, et al. "Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis." Cancer Research 82, no. 12_Supplement (2022): 3506. http://dx.doi.org/10.1158/1538-7445.am2022-3506.

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Abstract Natural killer (NK) cells play a central role in the immune surveillance of cancer. NK cells express multiple inhibitory and activating surface receptors, including the activating receptor, NKG2D. Engagement of NKG2D by the stress-induced ligands MICA/MICB stimulates NK cell activation and subsequent target cell lysis. While MICA/MICB expression is restricted in normal tissues, expression is strongly induced upon viral infection, genotoxic stress or malignant transformation. In cancer patients, the tumor microenvironment (TME) facilitates evasion of immune surveillance by NK cells. On
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Huang, Jingquan, Yumeng Teng, Peng Yan, et al. "MICA+ Tumor Cells Modulate Macrophage Phenotype and Function via PPAR/EHHADH-Mediated Fatty Acid Metabolism in Hepatocellular Carcinoma (HCC)." Cancers 17, no. 14 (2025): 2365. https://doi.org/10.3390/cancers17142365.

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Background: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), and the metabolic activities of both tumor cells and TAMs have an impact on the TME. Moreover, the expression of MICA in tumor cells is closely associated with immune cells in hepatocellular carcinoma (HCC). However, it remains unclear whether MICA expression correlates with TAMs and influences the switch in macrophage phenotype by mediating metabolic alterations. Methods: Various biostatistical tools, qPCR, and IHC staining experiments were utilized to analyze data from The Cancer Genome A
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33

Salih, Helmut Rainer, Holger Antropius, Friederike Gieseke, et al. "Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia." Blood 102, no. 4 (2003): 1389–96. http://dx.doi.org/10.1182/blood-2003-01-0019.

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Abstract NKG2D ligands (NKG2DLs) mark malignant cells for recognition by natural killer (NK) cells and cytotoxic T lymphocytes via the activating immunoreceptor NKG2D. This led to the hypothesis that NKG2DLs play a critical role in tumor immune surveillance. The human NKG2DLs MICA and MICB are expressed on tumors of epithelial origin in vivo. For the other recently described set of human NKG2DLs, the UL16-binding proteins (ULBPs), expression in vivo is as yet undefined. In this study we investigated expression and function of NKG2DLs in leukemia using a panel of newly generated NKG2DL-specific
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Stolbovaya, A. Yu, and I. V. Smirnov. "Mutation hot spots in MICA/MICB extracellular domains." Medical Immunology (Russia) 25, no. 3 (2023): 483–88. http://dx.doi.org/10.15789/1563-0625-mhs-2680.

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MICA and MICB are non-classical MHC molecules that indicate cellular stress. They act as ligands for NKG2D receptors found on NK cells, thereby triggering a cytotoxic response against damaged, infected, or transformed cells. The production of soluble forms of MICA/MICB occurs via the cleavage of their extracellular domains (ECDs). The expression of MICA/MICB molecules in tumor sections or the levels of their soluble forms in blood have potential as diagnostic tools for cancer. They can predict important clinical outcomes for cancer patients, such as overall and recurrence-free survival. Howeve
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Kato, N., V. Kumar, R. Muroyama, et al. "651 MICA PLAYS AN OPPOSITE ROLE IN HEPATOCARCINOGENESIS BETWEEN HEPATITIS B AND HEPATITIS C." Journal of Hepatology 58 (April 2013): S265. http://dx.doi.org/10.1016/s0168-8278(13)60653-4.

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Janhavi, Rajeev Korde, Sanjay Deshmukh Digvijay, and Pawar Sagar. "Urban Renewal: A Need to Redefine and Rebuild the Old City Area – Case of Thane, Kalyan-Dombivali and Mira Bhayander." International Journal of Engineering and Advanced Technology (IJEAT) 12, no. 1 (2022): 44–46. https://doi.org/10.35940/ijeat.A3831.1012122.

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<strong>Abstract: </strong>Urban renewal initiatives play an important role in achieving the targets of making human settlements and cities safe, inclusive, resilient and sustainable. Urban Renewal in India is a comprehensive presentation of strategic, technical and theoretical aspects of urban areas. &lsquo;Urban Renewal&rsquo; refers redevelopment of urban areas to ensure quality of life, growth of infrastructure, promotion of tourism. The paper describes the tools or approaches for urban renewal namely slum clearance, redevelopment and rehabilitation. To describe the urban renewal scenario
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Perrin, G., S. T. Ridgway, S. Lacour, et al. "Evidence for localized onset of episodic mass loss in Mira." Astronomy & Astrophysics 642 (October 2020): A82. http://dx.doi.org/10.1051/0004-6361/202037443.

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Context. Mass loss from long-period variable stars (LPV) is an important contributor to the evolution of galactic abundances. Dust formation is understood to play an essential role in mass loss. It has, however, proven difficult to develop measurements that strongly constrain the location and timing of dust nucleation and acceleration. Aims. Interferometric imaging has the potential to constrain the geometry and dynamics of mass loss. High angular resolution studies of various types have shown that LPVs have a distinct core-halo structure. These have also shown that LPV images commonly exhibit
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Fernandez-Vina, Marcelo, Pedro Cano, Ping Liu, et al. "62-W: Mismatches in DPB1, DQB1, DRB3/4/5 and MICA play a significant role in allogeneic HSC transplantation." Human Immunology 69 (October 2008): S132. http://dx.doi.org/10.1016/j.humimm.2008.08.272.

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Mantovani, Stefania, Stefania Varchetta, Dalila Mele, et al. "An Anti-MICA/B Antibody and IL-15 Rescue Altered NKG2D-Dependent NK Cell Responses in Hepatocellular Carcinoma." Cancers 12, no. 12 (2020): 3583. http://dx.doi.org/10.3390/cancers12123583.

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Natural killer (NK) cells play a pivotal role in cancer immune surveillance, and activating the receptor/ligand interaction may contribute to control the development and evolution of hepatocellular carcinoma (HCC). We investigated the role of the natural killer group 2 member D (NKG2D) activating receptor and its ligand, the major histocompatibility complex class I chain-related protein A and B (MICA/B) in patients with cirrhosis and HCC subjected to surgical resection, patients with cirrhosis and no HCC, and healthy donors (HD). The NKG2D-mediated function was determined in peripheral blood (
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40

Sandeepan, Saha*1 &. Prof. Dr. Sumit Kr. Biswas2. "A STUDY BETWEEN STRUCTURAL CORRELATION &MECHANICAL PROPERTIES OF SUB-GRADE SOIL WHEN BLENDED WITH LIME AND RICE HUSK ASH." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 8, no. 8 (2019): 23–31. https://doi.org/10.5281/zenodo.3360454.

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Present study considers structural characterization of sub-grade soil to increase the strength of soil for road. The present investigation has been carried out with agricultural waste materials like Rice Husk Ash individually mixed with soil and also in combination with different percentage of Hydrated Lime. Structural and mechanical characterization of the investigated samples was performed by X-Ray Diffraction (XRD), X-Ray Fluorescence (XRF), Standard Proctor Test, Unconfined Compression Test, California Bearing Ratio (CBR)Test. It was observed that increase of strength may be due to the red
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Franco-Sepúlveda, Giovanni, and Danilo Arturo Velilla-Avilez. "PLANEAMIENTO MINERO COMO FUNCIÓN DE LA VARIACIÓN DE LA LEY DE CORTE CRÍTICA." Boletín de Ciencias de la Tierra, no. 35 (January 1, 2014): 25–30. http://dx.doi.org/10.15446/rbct.n35.34650.

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Los accionistas de proyectos mineros buscan cada vez obtener el mayor rendimiento de las inversiones que realizan en la industria de la explotación de recursos no renovables. La ley de corte crítica (LCC) se ha convertido entonces en el parámetro de decisión que determina la viabilidad económica de un proyecto. En el presente artículo se determina la LCC óptima de un depósito mineral hipotético con la que se pretende maximizar el valor presente neto (VPN) de la operación, determinando como influye el cambio de ésta en el planeamiento de la mina. El trabajo se desarrolla haciendo uso del algori
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Antônia, de Melo Bahia, Rodrigues Andrade Ellem, Rodrigues de Souza Jessica, Said Mota Noélia, Araújo Guimarães Rosione, and Prof.ª. Noélia Medeiros Araújo Orientadora. "GERENCIAMENTO DE ENFERMAGEM NA UNIDADE BÁSICA DE SAÚDE- UBS: RELATO DE EXPERIÊNCIA." Revistaft 28, no. 132 (2024): 87. https://doi.org/10.5281/zenodo.10774987.

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Relata uma experi&ecirc;ncia acad&ecirc;mica de visita t&eacute;cnica a Unidade B&aacute;sica de Sa&uacute;de e sua contribui&ccedil;&atilde;o para aprendizado dos acad&ecirc;micos de enfermagem sobre o Gerenciamento de Enfermagem da Universidade Nilton Lins, com intuito de vivenciar o trabalho da equipe de enfermagem no gerenciamento, com uso da ferramenta Plan, Do, Check, Action (PDCA). A implanta&ccedil;&atilde;o do ciclo PDCA na sa&uacute;de &eacute;, ent&atilde;o, um processo que traz melhoria cont&iacute;nua, uma demanda muito latente da &aacute;rea. Quanto mais essa cultura vai se enrai
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Radulović, Ksenija. "Mira Trailović: Being alone in theatre (on the occasion of one hundred years since her birth 1924-2024)." Zbornik Akademije umetnosti, no. 12 (2024): 120–33. http://dx.doi.org/10.5937/zbaku2412120r.

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The centenary of the birth of Mira Trailović (1924-1989) is a formal occasion, but not the primary reason for reflecting on her professional activity and unique place in our culture. This paper focuses on aspects of Mira Trailović's public persona that do not belong to the dominant narratives about this theatre manager/leader and director. This means that we view her public persona beyond (or "beneath") attributes related to gender and the stereotypes that arise from them, as well as beyond the proverbial anecdotal domain in which she was often pigeonholed. We sharpen her place in the historic
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Nuryah, Mila, Ferry Ferdianto, and Supriyadi Supriyadi. "Analisis Kesalahan Siswa dalam Menyelesaikan Soal Persamaan dan Pertidaksamaan Nilai Mutlak Berdasarkan Langkah Penyelesaian Polya." Journal of Medives : Journal of Mathematics Education IKIP Veteran Semarang 4, no. 1 (2020): 63. http://dx.doi.org/10.31331/medivesveteran.v4i1.983.

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Penelitian ini adalah penelitian deskriptif kualitatif yang bertujuan untuk menganalisis jenis-jenis kesalahan dan persentase kesalahan yang dilakukan siswa kelas X MIPA 2 SMA Negeri 1 Gegesik dalam menyelesaikan soal persamaan dan pertidaksamaan nilai mutlak berdasarkan langkah penyelesaian Polya. Metode yang digunakan adalah metode penelitian yang digunakan adalah metode deskriptif kualitatif dengan menggunakan instrumen pengumpulan data berupa soal tes essay dan lembar wawancara.. instrumen yang digunakan terlebih dahulu diuji validitasnya. Subjek penelitian ini adalah 36 siswa kelas X MIPA
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Herold, Katharina. "Allegories on the international scene: Vernon Lee’s, Mina Loy’s, and Else Lasker-Schüler’s war plays." Feminist Modernist Studies 4, no. 2 (2021): 203–21. http://dx.doi.org/10.1080/24692921.2021.1950472.

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McShan, D. L., M. L. Kessler, K. Vineberg, and B. A. Fraass. "Inverse plan optimization accounting for random geometric uncertainties with a multiple instance geometry approximation (MIGA)." Medical Physics 33, no. 5 (2006): 1510–21. http://dx.doi.org/10.1118/1.2191016.

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Jarduli, Luciana Ribeiro, Ana Maria Sell, Pâmela Guimarães Reis, et al. "Role ofHLA,KIR,MICA, and Cytokines Genes in Leprosy." BioMed Research International 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/989837.

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Many genes includingHLA,KIR, andMICAgenes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease.HLAalleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease. Some combinations ofHLAandKIRmay result in negative as well as positive interactions between NK cells and infected host cells withM. leprae, resulting in activation or inhibition of NK cells and, consequently, in death of bacillus. In addition, studies have demonstrated the influence ofMICAgenes in the pathogenesis of leprosy. Specifically, they
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Stepanchuk, Vadim N. "Bifacial component of Mira, Layer I lithic assemblage." Journal of the International Union of Prehistoric and Protohistoric Sciences 3, no. 2 (2021): 94–109. http://dx.doi.org/10.62526/h4cf72.

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Located in the Dnieper valley and dated to ca. 32,000–31,000 cal BP, the site of Mira is characterized by the high level of conservation of human activity evidence. An important specificity of the site is its position in area without lithic raw material outcrops. The lithic industry of Mira, Layer I with confidence can be regarded as homogenous and containing no admixtures. At the same time, it is multi-component and includes specific Middle and Upper Palaeolithic tool types. Bifacial products constitute the essential archaic feature and are the focus of the presented paper. As a pivotal issue
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Monguí-Galvis, Ana María, Edwin Alexander Puentes-Balaguera, and Román Ortega. "Diagnóstico y plan de gestión de manejo ambiental mina didáctica del SENA Facultad - Área de ingeniería." ECOMATEMATICO 3, no. 1 (2012): 74–83. http://dx.doi.org/10.22463/17948231.145.

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Con el fin de dar cumplimiento a la Legislación existente en Colombia en materia ambiental, se hace necesario implementar planes, programas, políticas, para generar una cultura ambiental, adecuada a las necesidades reales al área de explotación del Centro Nacional Minero CNM, Mina Didáctica del SENA, donde se efectuó un diagnóstico de las condiciones ambientales actuales, y se tomaron medidas que generan el mejoramiento de las circunstancias del desarrollo de la actividad minero ambiental y educativa, desarrollada por el CNM del SENA.&#x0D;
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Becker, Jerry P., Edward A. Silver, Mary Grace Kantowski, Kenneth J. Travers, and James W. Wilson. "Some Observations of Mathematics Teaching in Japanese Elementary and Junior High Schools." Arithmetic Teacher 38, no. 2 (1990): 12–21. http://dx.doi.org/10.5951/at.38.2.0012.

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A U.S.–Japan Seminar on Mathematical Problem Solving was held at the East-West Center in Honolulu 14– 18 July 1986 (Becker and Miwa 1987). Among the seminar's proposals was that cross-cultural research on American and Japanese students' problem-solving behaviors be organized and carried out. The author were in Japan in the fall of 1988 to meet with their Japanese counterparts, plan research, and make visits to mathematics classrooms preliminary to conducting a two-year program of research. In addition to planning the research, we were on a fact-finding visit to classrooms to better acquaint ou
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