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Artykuły w czasopismach na temat „Moi-pro”

Autor: Grafiati

Data publikacji: 16 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Cardona-Mendoza, Andrés, Nelly Stella Roa Molina, Diana Marcela Castillo, Gloria Inés Lafaurie, and Diego Fernando Gualtero Escobar. "Human Coronary Artery Endothelial Cell Response to Porphyromonas gingivalis W83 in a Collagen Three-Dimensional Culture Model." Microorganisms 12, no. 2 (2024): 248. http://dx.doi.org/10.3390/microorganisms12020248.

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P. gingivalis has been reported to be an endothelial cell inflammatory response inducer that can lead to endothelial dysfunction processes related to atherosclerosis; however, these studies have been carried out in vitro in cell culture models on two-dimensional (2D) plastic surfaces that do not simulate the natural environment where pathology develops. This work aimed to evaluate the pro-inflammatory response of human coronary artery endothelial cells (HCAECs) to P. gingivalis in a 3D cell culture model compared with a 2D cell culture. HCAECs were cultured for 7 days on type I collagen matric

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Militzer, Burkhard, and William B. Hubbard. "Relation of Gravity, Winds, and the Moment of Inertia of Jupiter and Saturn." Planetary Science Journal 4, no. 5 (2023): 95. http://dx.doi.org/10.3847/psj/acd2cd.

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Abstract We study the relationship of zonal gravity coefficients, J 2n , zonal winds, and axial moment of inertia (MoI) by constructing models for the interiors of giant planets. We employ the nonperturbative concentric Maclaurin spheroid method to construct both physical (realistic equation of state and barotropes) and abstract (small number of constant-density spheroids) interior models. We find that accurate gravity measurements of Jupiter’s and Saturn’s J 2, J 4, and J 6 by the Juno and Cassini spacecraft do not uniquely determine the MoI of either planet but do constrain it to better than

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Rice, J. Hunter, Margaret M. McDaniel, Alyson Holland, and Shigetoshi Eda. "Modelling Bovine Granuloma Formation In Vitro upon Infection with Mycobacterium Avium Subspecies Paratuberculosis." Veterinary Sciences 6, no. 4 (2019): 80. http://dx.doi.org/10.3390/vetsci6040080.

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Mycobacterium avium subspecies paratuberculosis (Map) causes chronic granulomatous disease in cattle and ruminant livestock, causing substantial economic losses. Current vaccines delay clinical signs but cannot train the immune system to fully eradicate latent Map. During latency, Map uses host defenses, cage-like macrophage clusters called granuloma, as incubators for months or years. We used an in vitro model to investigate the early coordination of macrophages into granuloma upon Map infection over ten days. We found that at multiplicities of infection (MOI; Map:macrophages) of 1:2 and belo

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Maldonado, David, Vivian Ouyang, Jade Owens, et al. "Paper 57: Labral Tear Management in Patients Aged 40 Years and Older Undergoing Primary Hip Arthroscopy: A Propensity-Matched Case-Control Study Comparing Labral Reconstruction to Labral Repair with Minimum Two-Year Follow-Up. *ACCEPTED TO AJSM*." Orthopaedic Journal of Sports Medicine 10, no. 7_suppl5 (2022): 2325967121S0062. http://dx.doi.org/10.1177/2325967121s00620.

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Objectives: To report minimum two-year patient-reported outcome (PRO) scores, survivorship, and secondary surgeries, in patients aged ≥ 40 years who underwent primary hip arthroscopy with labral reconstruction compared to a propensity-matched primary labral repair group. Methods: Data were prospectively collected and retrospectively reviewed for patients who underwent a primary hip arthroscopy for femoroacetabular impingement syndrome from January 2014 to June 2018. Patients aged ≥ 40 years who underwent a labral reconstruction or a labral repair and had preoperative and minimum two-year PROs

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Maldonado, David R., Vivian W. Ouyang, Jade S. Owens, et al. "Labral Tear Management in Patients Aged 40 Years and Older Undergoing Primary Hip Arthroscopy: A Propensity-Matched Case-Control Study With Minimum 2-Year Follow-up." American Journal of Sports Medicine 49, no. 14 (2021): 3925–36. http://dx.doi.org/10.1177/03635465211046915.

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Background: Previous literature has suggested that primary acetabular labral reconstruction leads to lower secondary surgery rates than does labral repair for patients aged ≥40 years. Purpose: To report minimum 2-year patient-reported outcome (PRO) scores, survivorship, and secondary surgeries in patients aged ≥40 years who underwent primary hip arthroscopy with labral reconstruction compared with a propensity-matched primary labral repair group. Study Design: Case-control study; Level of evidence, 3. Methods: Data were prospectively collected and retrospectively reviewed for patients who unde

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L Katche, Musong, Augustine B Makokha, Siagi O Zachary, and Muyiwa S Adaramola. "Solar Photovoltaic Systems: A Technical and Economic Feasibility Design Approach with Homer Pro." International Journal of Advances in Scientific Research and Engineering 09, no. 11 (2023): 21–30. http://dx.doi.org/10.31695/ijasre.2023.9.11.2.

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With the declining cost of solar photovoltaic (PV) modules and batteries used for energy storage, many users are now shifting towards solar energy because of its renewable nature and availability. Though this is a great step to combat climate change, most of the solar systems installed always fail due to poor system sizing. For this reason, optimal systems are required to be deployed. This paper presents a technical and economic feasibility design approach for a solar PV system using Hybrid Optimization of Multiple Energy Resources (HOMER) Pro software. The design is based on site-specific dat

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Bajaber, Gamar, Constantine Akwanalo, and Shameem Ali. "Proportion, Precipitators and Prognostic Marker of 30-Day Heart Failure Readmission at MOI Teaching and Referral Hospital, Eldoret, Kenya." International Journal of Research and Scientific Innovation VII, no. XI (2023): 110–25. http://dx.doi.org/10.51244/ijrsi.2023.1011008.

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Background: Heart failure (HF) affects 26 million people globally. It is associated with a high 30-day readmission rate due to multiple cardiovascular and non-cardiovascular precipitants. Readmissions are associated with high mortality, which may be predicted by pre-discharge N-terminal pro brain natriuretic peptide (NT-proBNP). There is no data on HF readmission rates, its precipitators and use of NT-proBNP as a prognostic marker at Moi Teaching and Referral Hospital (MTRH) in Western Kenya. Objective: To determine the 30-day proportion of HF readmission, the precipitators of HF and the assoc

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A . Hussein, Ahmed, and Adnan F. Hassan. "Performance Enhancement of Luminescent Solar Concentrator by using Mixing Fluorescent Colors and Nanoparticles." Journal of Kufa-Physics 14, no. 01 (2022): 17–25. http://dx.doi.org/10.31257/2018/jkp/2022/140106.

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Liquid zinc acetate nanoparticles were added to a fluorescent organic dye (fluorescein sodium) to prepare three concentrations (2 × 10-5, 7×10-5, 1×10-4) moI/L, and the absorbance of the dye was measured before and after adding Liquid nanomaterial by using two devices (SCINCO Mega-2100 UV/visible Spectrophotometer.) as well as measuring the flux of the dye before and after adding zinc acetate nanoparticles using the (Spectrofluorometer F96 PRO). The Stoke displacement (Δη), the radiative age (τfm), the fluorescence lifetime (τf), and the quantitative efficiency (Qfm) were calculated. Absorptio

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Barletta, Raul G., John P. Bannantine, Judith R. Stabel, et al. "Mycobacterium avium subsp. paratuberculosis Candidate Vaccine Strains Are Pro-apoptotic in RAW 264.7 Murine Macrophages." Vaccines 11, no. 6 (2023): 1085. http://dx.doi.org/10.3390/vaccines11061085.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne’s disease, a severe gastroenteritis of ruminants. This study developed a model cell culture system to rapidly screen MAP mutants with vaccine potential for apoptosis. Two wild-type strains, a transposon mutant, and two deletion mutant MAP strains (MOI of 10 with 1.2 × 106 CFU) were tested in murine RAW 264.7 macrophages to determine if they induce apoptosis and/or necrosis. Both deletion mutants were previously shown to be attenuated and immunogenic in primary bovine macrophages. All strains had similar growth

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Knezevic, Petar, Aleksandra Petrovic Fabijan, Damir Gavric, Jovana Pejic, Zsolt Doffkay, and Gábor Rakhely. "Phages from Genus Bruynoghevirus and Phage Therapy: Pseudomonas Phage Delta Case." Viruses 13, no. 10 (2021): 1965. http://dx.doi.org/10.3390/v13101965.

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The applicability and safety of bacteriophage Delta as a potential anti-Pseudomonas aeruginosa agent belonging to genus Bruynoghevirus (family Podoviridae) was characterised. Phage Delta belongs to the species Pseudomonas virus PaP3, which has been described as a temperate, with cos sites at the end of the genome. The phage Delta possesses a genome of 45,970 bp that encodes tRNA for proline (Pro), aspartic acid (Asp) and asparagine (Asn) and does not encode any known protein involved in lysogeny formation or persistence. Analysis showed that phage Delta has 182 bp direct terminal repeats at th

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Ochwoto, Missiani, Colins O. Oduma, Julius Oyugi, et al. "Human TP53 gene polymorphisms among patients with hepatocellular carcinoma and chronic hepatitis B in Kenya." F1000Research 8 (August 6, 2019): 1364. http://dx.doi.org/10.12688/f1000research.19416.1.

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Background: Human TP53 is the gatekeeper for generation of human cells and is highly conserved. Any alteration/mutation to TP53 adversely affects the regulatory function of the protein, potentially resulting in cancer. This study investigated mutations in codons 7 and 249 of TP53, among patients with hepatocellular carcinoma (HCC) and chronic hepatitis B virus (HBV) infection at the Moi Teaching and Referral Hospital (MTRH), Eldoret, Kenya. Methods: In total, 33 HBV-positive patients attending MTRH hospital between September 2013 and July 2017 were purposely selected from medical records for t

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Ochwoto, Missiani, Colins O. Oduma, Julius Oyugi, et al. "Human TP53 gene polymorphisms among patients with Hepatocellular carcinoma and chronic hepatitis B infection in Kenya." F1000Research 8 (March 12, 2024): 1364. http://dx.doi.org/10.12688/f1000research.19416.2.

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Background Human TP53 is the gatekeeper for generation of human cells and is highly conserved. Some alteration/mutation in TP53 adversely affects the regulatory function of the protein, potentially resulting in cancer. This study investigated mutations in codons 72 and 249 of TP53, among patients with hepatocellular carcinoma (HCC) and chronic hepatitis B virus (HBV) infection at the Moi Teaching and Referral Hospital (MTRH), Eldoret, Kenya. Methods In total, 33 HBV-positive patients attending MTRH hospital between September 2013 and July 2017 were purposely selected from medical records for t

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Loeffler, Juergen, Markus Mezger, and Hermann Einsele. "Mycophenolic Acid Causes Dysfunction of Human Polymorphonuclear Neutrophils and Dendritic Cells during the Interaction with Aspergillus fumigatus." Blood 110, no. 11 (2007): 3849. http://dx.doi.org/10.1182/blood.v110.11.3849.3849.

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Abstract Immunosuppressive drugs are a variety of substances to prevent transplant rejection. There is increasing data that immunosuppressants not only modulate lymphocyte function but also interfere with other immune effector cells. In this study, we analyzed the influence of Mycophenolic acid (MPA) on the activity of human polymorphonuclear neutrophils (PMNs) and dendritic cells (DCs) during the interaction with the mold Aspergillus fumigatus. PMNs were obtained from blood using Bicoll separation. Release of reactive oxygen species (ROS) was detected photometrically by using dichlorofluoresc

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Tajiknia, Vida, Noe Mercado, Eain Murphy, and Sean lawler. "CSIG-23. CYTOMEGALOVIRUS-INFECTED HUMAN GLIOBLASTOMA CELL LINES SHOW AN AGGRESSIVE PHENOTYPE ASSOCIATED WITH UPREGULATION OF IL-6/STAT3 AND AKT SIGNALING." Neuro-Oncology 26, Supplement_8 (2024): viii68—viii69. http://dx.doi.org/10.1093/neuonc/noae165.0272.

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Abstract BACKGROUND Cytomegalovirus (CMV) has been implicated in glioblastoma (GBM) pathogenesis by affecting stemness, angiogenesis and immune pathways. Clinical trials targeting CMV in GBM patients have shown some early promise, and CMV seropositivity has been associated with poorer outcomes. However, the underlying mechanisms remain unclear. Here we investigated the effects of CMV infection on critical signaling pathways in GBM (IL6/STAT3, and Akt signaling) based on the hypothesis that CMV may contribute to poorer outcomes in GBM by increasing oncogenic signaling. MATERIALS AND METHODS Hum

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Valverde, Araceli Maria, Samantha Schaller, and Afsar Raza Naqvi. "MicroRNA and periodontal pathogen interaction in shaping innate immune response." Journal of Immunology 206, no. 1_Supplement (2021): 112.08. http://dx.doi.org/10.4049/jimmunol.206.supp.112.08.

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Abstract MicroRNA (miR) play a critical role in the pathogenesis of immune-mediated diseases, however, their role in periodontal disease (PD) remain poorly studied. We hypothesize that periopathogens (P. gingivalis [Pg] and A. actinomycemtemcomitans [Aa]) impair host immune response by perturbing miR expression. Naïve CD14+ monocytes were isolated from human PBMC and differentiated to M1 MΦ or M2 MΦ in presence of GM-CSF or M-CSF for 7 days. Cells were challenged with Pg or Aa (both 100 MOI) for 4 h and 24 h. Total RNA was isolated to quantitate expression of pro- and anti-inflammatory miRNAs,

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Babalghith, Ahmad O., Hayder M. Al-kuraishy, Ali I. Al-Gareeb, et al. "The Potential Role of Growth Differentiation Factor 15 in COVID-19: A Corollary Subjective Effect or Not?" Diagnostics 12, no. 9 (2022): 2051. http://dx.doi.org/10.3390/diagnostics12092051.

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Coronavirus disease 2019 (COVID-19) is primarily caused by various forms of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants. COVID-19 is characterized by hyperinflammation, oxidative stress, multi-organ injury (MOI)-like acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Different biomarkers are used in the assessment of COVID-19 severity including D-dimer, ferritin, lactate dehydrogenase (LDH), and hypoxia-inducible factor (HIF). Interestingly, growth differentiation factor 15 (GDF15) has recently become a potential biomarker correlated with the

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Katche, Musong L., Augustine B. Makokha, Siagi O. Zachary, and Muyiwa S. Adaramola. "Techno-Economic Assessment of Solar–Grid–Battery Hybrid Energy Systems for Grid-Connected University Campuses in Kenya." Electricity 5, no. 1 (2024): 61–74. http://dx.doi.org/10.3390/electricity5010004.

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This paper presents the techno-economic feasibility of using grid-connected PV hybrid systems to supply power in large grid-dependent academic institutions. The study was conducted using the administration building of Moi University in Kenya. The power consumption profile of the building was collected using a PCE-360 power analyzer. The peak load demand was found to be 60 kW. Using random variability constants of 4% for day-to-day and 4% time-step load variability, a peak demand of 70.58 kW was obtained, which was used in our simulation. The solar radiation and temperature data for this site w

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Snuggs, J., R. Senter, J. Whitt, and C. Le Maitre. "PCRX-201, A NOVEL GENE THERAPY TREATMENT APPROACH FOR INTERVERTEBRAL DISC DEGENERATION." Orthopaedic Proceedings 105-B, SUPP_9 (2023): 91. http://dx.doi.org/10.1302/1358-992x.2023.9.091.

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Low back pain affects 80% of the population with half of cases attributed to intervertebral disc (IVD) degeneration. However, the majority of treatments focus on pain management, with none targeting the underlying pathophysiological causes. PCRX-201 presents a novel gene therapy approach that addresses this issue. PCRX-201 codes for interleukin-1 receptor antagonist (IL-1Ra), the natural inhibitor of the pro-inflammatory cytokine IL-1, which orchestrates the catabolic degeneration of the IVD. Our objective here is to determine the ability of PCRX-201 to infect human nucleus pulposus (NP) cells

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Fox, Sarah, Kieran Ryan, Soumita Das, Shiela Crowe, and Peter Ernst. "C1q promotes recognition and engulfment of H. pylori infected AGS cells and modulates inflammatory cytokine production in macrophages. (P4019)." Journal of Immunology 190, no. 1_Supplement (2013): 131.10. http://dx.doi.org/10.4049/jimmunol.190.supp.131.10.

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Abstract H pylori resides in the gastric lumen and is a significant risk factor for gastritis and gastric cancer. This organism promotes apoptosis of gastric epithelial cells that are subsequently cleared by local phagocytes. C1q, the recognition component of the complement cascade, is an important molecule in immune regulation where it promotes uptake of apoptotic cells and modulates inflammation. We demonstrated that H pylori infection induces apoptosis of gastric AGS cells in vitro and that apoptotic epithelial cells are recognized and engulfed by macrophages independent of the method of ce

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Shymialevich, Dziyana, Stanisław Błażejak, Paulina Średnicka, et al. "Biological Characterization and Genomic Analysis of Three Novel Serratia- and Enterobacter-Specific Virulent Phages." International Journal of Molecular Sciences 25, no. 11 (2024): 5944. http://dx.doi.org/10.3390/ijms25115944.

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Due to the high microbiological contamination of raw food materials and the increase in the incidence of multidrug-resistant bacteria, new methods of ensuring microbiological food safety are being sought. One solution may be to use bacteriophages (so-called phages) as natural bacterial enemies. Therefore, the aim of this study was the biological and genomic characterization of three newly isolated Serratia- and Enterobacter-specific virulent bacteriophages as potential candidates for food biocontrol. Serratia phage KKP_3708 (vB_Sli-IAFB_3708), Serratia phage KKP_3709 (vB_Sma-IAFB_3709), and En

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Tajiknia, Vida, Noe Mercado, Jacquelin Real, Eain Murphy, and Sean Lawler. "Abstract 3070: Cytomegalovirus infection enhances spheroid formation and drives aggressive phenotype in glioblastoma via upregulation of SOX2 pRB pAKT and STAT3/IL-6 signaling." Cancer Research 85, no. 8_Supplement_1 (2025): 3070. https://doi.org/10.1158/1538-7445.am2025-3070.

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Abstract Background: Cytomegalovirus (CMV) infection has been implicated in glioblastoma (GBM) progression, with effects on stemness, immune evasion, and angiogenesis. Our work investigates the impact of CMV infection on spheroid formation, oncogenic pathways including SOX2, retinoblastoma protein (pRB), phospho-AKT (pAKT), and STAT3/IL-6 signaling, as well as cytokine modulation. Additionally, we evaluate the therapeutic potential of ganciclovir in reversing CMV-induced effects. Methods: GBM cell lines LN229, U251, U87, U138, and T98G were infected with the GFP-expressing CMV TB40 strain at a

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Schab, Andrew, Benjamin Kuhns, Elizabeth Walsh, Roger Quesada-Jimenez, Ady Kahana-Rojkind, and Benjamin Domb. "EP1.28 Minimum Two-Year Outcomes of Iliopsoas Tunnel Deepening Compared Against Iliopsoas Fractional Lengthening in Primary Hip Arthroscopy." Journal of Hip Preservation Surgery 12, Supplement_1 (2025): i43—i44. https://doi.org/10.1093/jhps/hnaf011.138.

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Abstract Background: Iliopsoas impingement is a common cause of hip pain. Iliopsoas impingement has been treated with iliopsoas fractional lengthening (IFL), yet iliopsoas tunnel deepening (ITD) has emerged as a new treatment option. Purpose: To report minimum two-year outcomes of ITD during hip arthroscopy and compare their results to a propensity-matched benchmark control of hip arthroscopies performed with iliopsoas fractional lengthening (IFL). Study Design: Cohort study; Level of evidence, 3. Methods: Data was collected between December 2017 and January 2022 and retrospectively reviewed f

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Gaultier, Gaël. "Moi, jeune et privé d’emploi." Projet 361, no. 6 (2017): 5. http://dx.doi.org/10.3917/pro.361.0005.

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Rawls, Amy S., Jill R. Woloszynek, and Daniel C. Link. "Lentiviral-Mediated RNAi Knockdown of SBDS in Murine Hematopoietic Progenitors Impairs Their Engraftment Potential and Granulocytic Differentiation." Blood 106, no. 11 (2005): 635. http://dx.doi.org/10.1182/blood.v106.11.635.635.

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Abstract Shwachman-Bodian Diamond Syndrome (SDS) is an autosomal recessive disorder characterized by congenital neutropenia, pancreatic exocrine insufficiency and bony abnormalities. About 90% of SDS patients have mutations in the novel SBDS gene. The SBDS protein is conserved from archaea to mammals; however, the cellular functions of SBDS, as well as its contribution to the molecular pathogenesis of this disease, are not yet known. In this study, we developed an RNAi knockdown model to investigate the consequences of a reduction in SBDS protein on hematopoiesis. Three lentiviral RNAi constru

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Herzog, Philippe. "Plus social que moi, tu meurs." Projet 284, no. 1 (2005): 42. http://dx.doi.org/10.3917/pro.284.0042.

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Kumar, Ronald Ravinesh, Peter Josef Stauvermann, and Lien Thi Mai Dau. "Exploring the Tourism and Economic Growth Relationship in Vietnam: A Cointegration Analysis with Model-Specific Structural Breaks." Economies 13, no. 2 (2025): 29. https://doi.org/10.3390/economies13020029.

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In this study, we present a comprehensive analysis to examine the resilience of tourism in Vietnam since the Doi Moi period. Using an augmented Solow framework, data from 1986 to 2020, and the ARDL approach, we estimate the long-run and short-run effects, whilst accounting for model-specific structural breaks. To provide stronger validation and robustness of the results, we estimate eight models under four cases. We start with the base model, which includes tourism and capital (in per worker terms), and then augment it with factors that are carefully identified from the literature. The additio

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Stavrakaki, Eftychia, Wouter B. L. van den Bossche, Rutger Balvers, et al. "EXTH-54. CO-CULTURE OF PATIENT-DERIVED GLIOBLASTOMA CELL LINES WITH AUTOLOGOUS PBMCS FOR THE INVESTIGATION OF ONCOLYTIC VIRUS RESPONSE." Neuro-Oncology 24, Supplement_7 (2022): vii221. http://dx.doi.org/10.1093/neuonc/noac209.852.

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Abstract BACKGROUND The dismal prognosis of glioblastoma (GBM) patients, with a median survival of less than 15 months despite maximal therapy urgently warrants new therapeutic approaches. Clinical trials employing oncolytic viruses (OVs) have shown encouraging results, however, in each OV clinical trial only a small subset of patients responded to treatment. As inter-tumoral heterogeneity has been the key challenge in treating GBM, we hypothesized that development of an in vitro co-culture model for assessment of viral replication and subsequent immune response might ultimately predict in viv

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Allazkani, Nour, and Martin Monti-Lalaubie. "« L’engagement m’a appris à être moi-même »." Revue Projet N°373, no. 6 (2019): 5. http://dx.doi.org/10.3917/pro.373.0005.

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Kumar, Ashish, Quanzhi Li, Wendy A. Hudson, Thien N. Sam, Weili Chen, and John H. Kersey. "Evi1 Promotes Leukemogenesis by Anti-Apoptotic Rather Than Differentiation-Blocking Effects in Murine MLL-AF9 Leukemia." Blood 112, no. 11 (2008): 593. http://dx.doi.org/10.1182/blood.v112.11.593.593.

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Abstract In a search for molecular targets in MLL -leukemias, we found that transformed hematopoietic stem cells in knock-in MLL-AF9 mice expressed high levels of Evi1 compared to their wild type counterparts (Chen et al, Cancer Cell, 2008). About 50% of human AMLs with MLL rearrangements also express Evi1 and Evi1-expressing human leukemias are associated with an aggressive disease. The current experiments were designed to study mechanisms in which Evi1 is important for the pathogenesis of leukemia. To investigate its role in MLL-AF9 leukemia, we studied the effect of Evi1 knock-down in a cel

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Dugast, César, and Alexia Soyeux. "Les entreprises, l’État, le climat et moi : chacun sa part." Revue Projet N°375, no. 2 (2020): 38. http://dx.doi.org/10.3917/pro.375.0038.

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Vettraino, Jean. "Jade Lindgaard, JE CRISE CLIMATIQUE. La planète, ma chaudière et moi." Projet 343, no. 6 (2014): 93. http://dx.doi.org/10.3917/pro.343.0093.

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Raimondi, Vincenzo, Paola Storti, Rosanna Vescovini, et al. "Bovine Herpes Virus Type 1 Oncolytic Therapy Elicits Direct Cytotoxic Effects and Immune Microenvironment Reshaping in Multiple Myeloma." Blood 144, Supplement 1 (2024): 4660. https://doi.org/10.1182/blood-2024-200024.

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Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by a high tendency to relapse and develop drug resistance. In this context, immune dysregulation is a defining characteristic of MM, with interactions between malignant PCs and immune cells within the bone marrow (BM) microenvironment playing a crucial role in creating a tumor-promoting environment. Recently, therapeutic strategies have shown promise to overcome the immunosuppressive tumor microenvironment and activate the host immune system. Oncolytic viruses (OVs) are an emerging class of immunotherapy, exploiting tumor-spe

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Salafutdinov, Ilnur I., Dilara Z. Gatina, Мaria I. Markelova, et al. "Transcriptomic Landscape of Umbilical Cord Blood Mononuclear Cells after Genetic Modification." Blood 136, Supplement 1 (2020): 33–34. http://dx.doi.org/10.1182/blood-2020-138664.

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Introduction: Therapeutic application of umbilical cord blood mononuclear cells (UCB-MCs) has been actively studied for at least during the last 30 years. Currently, UCB-MCs are extensively being investigated in the regeneration of the central nervous system (CNS) and the treatment of human neurodegenerative disorders. Translational studies dedicated to the application of UCB-MCs have revealed their capacity for stimulation of neurogenesis in the aged brain and promising potency for being therapeutic agents for treating such diseases as Alzheimer`s disease, amyotrophic lateral sclerosis (ALS),

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Castro-Rea, Julián. "LA NATION, C’EST MOI: THE ENCOUNTER OF QUÉBEC AND ABORIGINAL NATIONALISMS." Constitutional Forum / Forum constitutionnel 13 (July 26, 2011): 2005. http://dx.doi.org/10.21991/c9t674.

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Proponents of Québec’s independence justify their goal with the claim that their province is the cradle of one of Canada’s “Founding Nations.” In so doing, they bypass the self-perception of the dominant, politicized Aboriginal peoples, who perceive themselves as forming the “First Nations” of what is now Canada. These contending views, neither of which is yet constitutionally fully recognized, are bound to clash whenever issues of self-government are raised within Québec’s boundaries. Such a situation arose at the time of the 1995 Québec referendum on sovereignty, which was met with adamant o

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Soares, Rodrigo Pedro, Igor Campos Fontes, Felipe Dutra-Rêgo, et al. "Unveiling the Enigmatic nature of six neglected Amazonian Leishmania (Viannia) species using the hamster model: Virulence, Histopathology and prospection of LRV1." PLOS Neglected Tropical Diseases 18, no. 8 (2024): e0012333. http://dx.doi.org/10.1371/journal.pntd.0012333.

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American tegumentary leishmaniasis (ATL) is highly endemic in the Amazon basin and occurs in all South American countries, except Chile and Uruguay. Most Brazilian ATL cases are due to Leishmania (Viannia) braziliensis, however other neglected Amazonian species are being increasingly reported. They belong to the subgenus L. (Viannia) and information on suitable models to understand immunopathology are scarce. Here, we explored the use of the golden hamster Mesocricetus auratus and its macrophages as a model for L. (Viannia) species. We also studied the interaction of parasite glycoconjugates (

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Khan, Humayara, Xiaoyun Tang, Frank Wuest, David N. Brindley, and Denise G. Hemmings. "Abstract A035: Infection of primary mammary fibroblasts with cytomegalovirus coordinately increases autotaxin-lysophosphatidate-inflammatory signaling, which could increase breast cancer metastasis." Cancer Research 84, no. 22_Supplement (2024): A035. http://dx.doi.org/10.1158/1538-7445.tumbody-a035.

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Abstract Background: Metastatic breast cancer is the most prevalent cause of mortality by cancer-related deaths in women. Our group showed that the 63% of Canadian breast cancer patients who were infected with CMV were 5.6-times more likely to develop Stage IV cancers with reduced relapse-free survival. Also, the metastatic phenotype of breast tumors and the number and sizes of lung metastases were increased in mice with latent infections. Fibroblasts are important sites of CMV infection. Cancer-associated fibroblasts (CAFs) are also major sites of autotaxin (ATX) secretion in breast tumors, w

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Yu, Lei, Greggory Myers, Beth McGee, et al. "Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II." Blood 142, Supplement 1 (2023): 12. http://dx.doi.org/10.1182/blood-2023-182246.

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Congenital dyserythropoietic anemia type II (CDA-II) is an autosomal recessive disease characterized by anemia, ineffective erythropoiesis, and increased bone marrow bi-nucleated erythroblasts. CDA-II is caused by loss-of-function mutations in SEC23B, which encodes a component of coat protein complex II (COP-II) vesicles/tubules that transport secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mammals express two SEC23 paralogs, SEC23A and SEC23B. We have previously shown that SEC23A is functionally interchangeable with SEC23B and that increased expression of SEC23A resc

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Franca Peri Giglio. "Modelo Educativo sustentado en Valores Espirituales para la vida, la autorrealización y trascendencia." GACETA DE PEDAGOGÍA, no. 48 (January 23, 2024): 17–30. http://dx.doi.org/10.56219/rgp.vi48.2438.

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La espiritualidad es la cualidad propia de la naturaleza trascendente del ser humano que define su sentido y propósito de vida. La educación juega un rol fundamental en este mecanismo de autoco-nocimiento y autorrealización ya que su finalidad no es sólo educare -instruir, entrenar- sino también educere -sacar a la luz, hacer salir-. Al respecto, la presente investigación desarrolló un modelo que operacionaliza lo espiritual a través de valores centrados en el autoconocimiento y la emancipación del Ser, e incorpora a los actores del hecho educativo como participantes activos del proceso en el

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Merkushova, E. D., E. M. Khasanova, and L. V. Gankovskaya. "Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy." Medical Immunology (Russia) 22, no. 3 (2020): 449–58. http://dx.doi.org/10.15789/1563-0625-moi-1949.

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Psoriasis is a chronic auto-inflammatory, genetically determined dermatosis, being multifactorial by origin, characterized by hyperproliferation of epidermis, affected keratinocyte differentiation and inflammatory reaction in dermis. The disease is characterized by a tendency to spread over the area of lesion, and involvement of articular tissue in the pathological process, which significantly affects the living standards of patients and causes their disability. There are many provoking factors that contribute to occurrence of psoriasis, or progression of existing psoriatic process in individu

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Дудник, Олена. "«ПРОСВІТА» УМАНЩИНИ ЗА ЧАСІВ УКРАЇНСЬКОЇ ЦЕНТРАЛЬНОЇ РАДИ". Уманська старовина, № 8 (30 грудня 2021): 177–88. http://dx.doi.org/10.31499/2519-2035.8.2021.249967.

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Ключові слова: «Просвіта», Уманський повіт, Київська губернія, культурно-освітня політика, Центральна Рада. Анотація Події Української революції 1917-1921 рр. сприяли заснуванню просвітницьких організацій, які своїм основним завданням вбачали надання різної допомоги населенню на ниві культурно-освітніх справ. У статті досліджується процес утворення товариств «Просвіта» в Уманському повіті Київської губернії. З огляду на вагомість реалізованих проектів в статті увага присвячена добі Центральної Ради.  Базуючись на архівних документах та матеріалах періодики, з’ясовано, що орга

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Finney, Lydia J., Peter Fenwick, Samuel V. Kemp, et al. "Impaired anti-viral immunity in frequent exacerbators of chronic obstructive pulmonary disease." American Journal of Physiology-Lung Cellular and Molecular Physiology, November 19, 2024. http://dx.doi.org/10.1152/ajplung.00118.2024.

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Background Respiratory viruses cause chronic obstructive pulmonary disease (COPD) exacerbations. Rhinoviruses (RVs) are the most frequently detected. Some COPD patients experience frequent exacerbations ({greater than or equal to}2 exacerbations/ year). The relationship between exacerbation frequency and anti-viral immunity remains poorly understood. Objectives To investigate the relationship between exacerbation frequency and anti-viral immunity in COPD Methods Alveolar macrophages and bronchial epithelial cells (BECs) were obtained from COPD patients and healthy participants. Alveolar macrop

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Ghassemi, Mehdi. "Possibility of Self-Representation: the Assimilation of Paul de Man’s Theories in John Banville’s Shroud." Mosaïque, no. 8 (June 1, 2013). http://dx.doi.org/10.54563/mosaique.1529.

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Shroud de John Banville, publié en 2002, peut être lu comme un exemple de « métafiction historiographique ». Le roman fonde en effet son protagoniste, Axel Vander, sur la vie de Paul de Man, le théoricien littéraire, dont les écrits dans un journal pro-nazi ont été découvert à titre posthume par Ortwin de Graef. Ce récit prend la forme d'une confession autobiographique, tout en s'appuyant sur les théories de Paul de Man concernant la question de la référentialité et le problème d '(auto-) représentation. En outre, selon de Man, le discours de l'autobiographie implique un processus d’« auto-res

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Sharma, Deepak Kumar, Bincy Joseph, Rajesh Singathia, Abhishek Gaurav, and Vishnu Kumar. "Inflammasome Activation and Pro-inflammatory Cytokine Genes Expression Following Exposure of PPRV in Vero Cells." Indian Journal of Animal Research, Of (July 14, 2023). http://dx.doi.org/10.18805/ijar.b-5102.

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Background: Peste des petits ruminants (PPR), a highly contagious and fatal disease of small ruminants, caused by PPR virus (PPRV). Detection of microbes is mediated by pattern recognition receptors (PRRs). These PRRs induce the assembly of a multi-protein signaling platform called the Inflammasome. It detects the pathogens and induces the synthesis of pro-inflammatory cytokines interleukins (IL) i.e. IL-1β and IL-18. The aim of this study was to assess the activation of inflammasome related genes, following exposure to PPRV in Vero Cells and was to assess the effect of activation of inflammas

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Cheng, You-Hung, Chun-Te Wu, Chih-Hao Chiu, et al. "A Comparative Study on Arthroscopic Superior Capsular Reconstruction Using Fascia Lata Autograft With and Without Long Head of the Biceps Tendon Augmentation: Two-Year Patient-Reported Outcomes and Radiographic Analysis." Orthopaedic Journal of Sports Medicine 12, no. 10 (2024). http://dx.doi.org/10.1177/23259671241270243.

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Background: Given the growing concerns regarding objective measures of clinical outcomes, attention has recently been devoted to the establishment of clinically significant outcome (CSO) thresholds for patient-reported functional scores after rotator cuff surgery. Purpose: To retrospectively compare patient-reported outcome (PRO) measures (PROMs) and radiographic data between patients who underwent arthroscopic superior capsular reconstruction (SCR) with and without long head of the biceps tendon (LHBT) augmentation. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 43 pati

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Marín-Palma, Damariz, Jorge H. Tabares-Guevara, María I. Zapata-Cardona, et al. "PM10 promotes an inflammatory cytokine response that may impact SARS-CoV-2 replication in vitro." Frontiers in Immunology 14 (April 25, 2023). http://dx.doi.org/10.3389/fimmu.2023.1161135.

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IntroductionIn the last decades, a decrease in air quality has been observed, mainly associated with anthropogenic activities. Air pollutants, including particulate matter (PM), have been associated with adverse effects on human health, such as exacerbation of respiratory diseases and infections. High levels of PM in the air have recently been associated with increased morbidity and mortality of COVID-19 in some regions of the world.ObjectiveTo evaluate the effect of coarse particulate matter (PM10) on the inflammatory response and viral replication triggered by SARS-CoV-2 using in vitro model

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Qin, Yue, Zuzanna Jablonska, Ursula Herbort-Brand, et al. "Abstract 4137609: Lentiviral shRNA Library Screen Using Human Pluripotent Stem Cell-derived Cardiomyocytes Identified Mediators of Protection via MAP4K4 Inhibition against Doxorubicin-induced Cardiotoxicity." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4137609.

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Background: Doxorubicin (Dox) is a common component in chemotherapy for a wide range of tumors, but the cardiotoxicity has restricted its use. There is an unmet need for novel therapeutics of Dox-induced cardiotoxicity (DIC). We previously identified the protein kinase MAP4K4 as a mediator of DIC. Notably, we showed that blocking MAP4K4 activity via DMX-5804 protected against Dox-induced cell death and dysfunction in human iPSCs derived cardiomyocytes (hiPSC-CMs). As a powerful tool to study the protective mechanism, pooled library screen performs high-throughput phenotypic examination, but it

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Somayajulu, Mallika, Sharon A. McClellan, Farooq Muhammed, Robert Wright, and Linda D. Hazlett. "PM10 and Pseudomonas aeruginosa: effects on corneal epithelium." Frontiers in Cellular and Infection Microbiology 13 (October 5, 2023). http://dx.doi.org/10.3389/fcimb.2023.1240903.

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PurposeIn vivo data indicate that mouse corneas exposed to PM10 showed early perforation and thinning after infection with Pseudomonas aeruginosa. To understand the mechanisms underlying this finding, we tested the effects of PM10 and the mitochondria targeted anti-oxidant SKQ1 in immortalized human corneal epithelial cells (HCET) that were challenged with Pseudomonas aeruginosa strain 19660.MethodsMouse corneas were infected with strain 19660 after a 2 week whole-body exposure to PM10 or control air and assessed by clinical scores, slit lamp photography and western blot. HCET were exposed to

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Zhang, Wei, Zhixing Li, Haitao Yang, et al. "Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways." Frontiers in Cellular and Infection Microbiology 11 (August 26, 2021). http://dx.doi.org/10.3389/fcimb.2021.691445.

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Aeromonas sobria, a common conditional pathogenic bacteria, is widely distributed in the environment and causes gastroenteritis in humans or septicemia in fish. Of all Aeromonas species, A. sobria is the most frequently isolated from human infections especially in immunocompromised subjects. Innate immunity is the first protection system of organism to resist non-specific pathogens invasion; however, the immune response process of hosts against A. sobria infection re\mains unexplored. The present study established an A. sobria infection model using primary mouse peritoneal macrophages (PMφs).

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Pitaloka, Dian, and Muti’ah Nurul Jihadah. "Comparing Responses of Ursolic Acid in Murine Macrophages Infected with Mycobacterium smegmatis and Mycobacterium avium." Indonesian Journal of Pharmacy, December 20, 2022, 602–9. http://dx.doi.org/10.22146/ijp.3507.

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Mycobacterium smegmatis and Mycobacterium avium offer an advantage in examining tuberculosis-like effects and host immune defense. Therefore, the study aims to examine the effect of ursolic acid (UA) on the host immune system by analyzing cytokines concentration, such as TNF-α, IL-6, IL-1β, and nitrite oxide produced by murine macrophages infected with Mycobacterium smegmatis and Mycobacterium avium. Femurs of female C57BL/6 mice aged 6–8 weeks were used to culture the Bone marrow-derived macrophages (BMDM). On day 10, BMDM was infected with Mycobacterium smegmatis and Mycobacterium avium usin

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Evani, Shankar J., Shatha Dallo, and Anand K. Ramasubramanian. "Abstract 16534: Remodeling of Intimal Matrix by C. Pneumoniae-infected Macrophages." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.16534.

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Introduction: Chlamydia pneumoniae, an intracellular pulmonary pathogen, is considered an important risk factor for atherosclerosis through the mechanisms is poorly understood. Infected monocytes from the lung enter atherosclerotic foci, and create a pro-inflammatory environment in the intima. Here, we tested the hypothesis that C. pneumoniae infection contributes to intimal matrix remodeling using a 3D model. Methods: Primary human monocytes infected with C. pneumoniae (either live of heat-killed organisms) at an MOI-1 were embedded in type I collagen matrix. Between 1 to 9 days, we analyzed

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