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Artykuły w czasopismach na temat „Monoclonal propagation”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Park, Jinho, Kyoung Seong Choi, and J. Stephen Dumler. "Major Surface Protein 2 of Anaplasma phagocytophilum Facilitates Adherence to Granulocytes." Infection and Immunity 71, no. 7 (2003): 4018–25. http://dx.doi.org/10.1128/iai.71.7.4018-4025.2003.

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ABSTRACT Anaplasma phagocytophilum is an obligate intracellular bacterium that infects myeloid cells in the mammalian host. Msp2 (p44) is the major immunodominant outer-membrane protein of these bacteria. We hypothesized that Msp2 acts as an adhesin for A. phagocytophilum entry into granulocytes. This potential role was investigated by blocking binding with Msp2 monoclonal antibodies and by antagonizing binding and propagation with recombinant Msp2 (rMsp2) in vitro. With HL-60 cells, fresh human peripheral blood neutrophils, and a cell line devoid of the fucosylated platelet selectin glycoprot

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2

Akhatkulov, Bakhriddin Matlabovich. "SCIENTIFIC, METHODOLOGICAL AND THEORETICAL FOUNDATIONS OF MODERN BIOTECHNOLOGIES IN POTATO SEED PRODUCTION." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 565–71. https://doi.org/10.5281/zenodo.15411255.

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<em>The article highlights the scientific, methodological, and theoretical foundations of using modern biotechnologies in potato seed production. Scientific approaches to the development of new potato varieties that are virus-free and adapted to climatic conditions using advanced biotechnological methods are studied. An analysis is conducted on genetic selection methods, molecular marking, plant tissue culture, monoclonal propagation, microbiological, ecological, and agronomic approaches, as well as "in vitro" propagation techniques and biological control measures.</em>

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Schluesener, H., C. Brunner, K. Vass, and H. Lassmann. "Therapy of rat autoimmune disease by a monoclonal antibody specific for T lymphoblasts." Journal of Immunology 137, no. 12 (1986): 3814–20. http://dx.doi.org/10.4049/jimmunol.137.12.3814.

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Abstract The central role of T lymphocytes in the initiation, regulation and propagation of autoimmune diseases defines them as most suitable targets for selective immunotherapy. The recent advance in culturing human and animal T cell lines allows us to select monoclonal antibodies specific for differentiation antigens expressed by activated T lymphocytes. We selected a monoclonal antibody cytotoxic for a subpopulation of activated rat T cells. In vivo, this antibody effectively blocks immune responses to foreign antigens or autoantigen and prevents development of autoimmune diseases like expe

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4

Norman, David J., and Anne M. Alvarez. "Monitoring the Spread of Xanthomonas Campestris pv. Dieffenbachiae Introduced from Symptomless Anthurium Cuttings into Production Fields." Journal of the American Society for Horticultural Science 121, no. 3 (1996): 582–85. http://dx.doi.org/10.21273/jashs.121.3.582.

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In field crops the origin and movement of bacterial inoculum is difficult to determine due to inadequate means of distinguishing strains of bacteria. In this study the introduction, establishment, and spread of Xanthomonas campestris pv. dieffenbachiae (McCulloch and Pirone) Dye into anthurium fields were examined by monitoring the distribution of serologically distinct strains recovered from propagation benches and production fields. One thousand Anthurium andraeanum Lind. plants were indexed for X. c. pv. dieffenbachiae and 962 were later introduced into a production field. Strains recovered

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5

Marquis, C. P., C. Harbour, J. P. Barford, and K. S. Low. "A comparison of different culture methods for hybridoma propagation and monoclonal antibody production." Cytotechnology 4, no. 1 (1990): 69–76. http://dx.doi.org/10.1007/bf00148812.

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Petyaev, Ivan M., Nayilia A. Zigangirova, Elena Y. Morgunova, Nigel H. Kyle, Elena D. Fedina, and Yuriy K. Bashmakov. "Resveratrol Inhibits Propagation ofChlamydia trachomatisin McCoy Cells." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/4064071.

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Resveratrol (RESV), an antifungal compound from grapes and other plants, has a distinct ability to inhibit theChlamydia (C.) trachomatisdevelopmental cycle in McCoy cells, a classic cell line used for chlamydial research. Inoculation ofC. trachomatiswith increasing amounts of RESV (from 12.5 to 100 μM) gave a dose-dependent reduction in the number of infected McCoy cells visualized by using monoclonal antibodies against chlamydial lipopolysaccharide. A similar trend has been observed with immunoassay for major outer membrane protein (MOMP). Furthermore, there was a step-wise reduction in the n

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7

Reuveny, S., D. Velez, L. Miller, and J. D. Macmillan. "Comparison of cell propagation methods for their effect on monoclonal antibody yield in fermentors." Journal of Immunological Methods 86, no. 1 (1986): 61–69. http://dx.doi.org/10.1016/0022-1759(86)90265-6.

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Sheoran, Abhineet S., Xiaochuan Feng, Inderpal Singh, et al. "Monoclonal Antibodies against Enterocytozoon bieneusi of Human Origin." Clinical Diagnostic Laboratory Immunology 12, no. 9 (2005): 1109–13. http://dx.doi.org/10.1128/cdli.12.9.1109-1113.2005.

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ABSTRACT Enterocytozoon bieneusi is clinically the most significant among the microsporidia infecting humans, causing chronic diarrhea, wasting, and cholangitis in individuals with human immunodeficiency virus/AIDS. The lack of immune reagents is largely due to the absence of methods for laboratory propagation of E. bieneusi. We recently described a procedure for the concentration and purification of spores from diarrheic stool of infected humans. Purified spores were used to immunize mice for production and screening of monoclonal antibodies (MAbs) against E. bieneusi. The eight immunoglobuli

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9

Bishop, A. L. "A Monoclonal Antibody Specific toAgrobacterium tumefaciensBiovar 3 and its Utilization for Indexing Grapevine Propagation Material." Phytopathology 79, no. 9 (1989): 995. http://dx.doi.org/10.1094/phyto-79-995.

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Wallisch, Michael, Yasser Khder, Monica T. Hinds, Erik I. Tucker, Dan Bloomfield, and Andras Gruber. "Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis." Blood 138, Supplement 1 (2021): 1027. http://dx.doi.org/10.1182/blood-2021-150535.

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Abstract Background: Factor XI (FXI) inhibition demonstrated strong efficacy in preventing thrombus formation in preclinical and clinical models of arterial and venous thrombosis. However, the effect of FXI inhibition in halting the progression of a formed clot remains largely unknown. Aims: This study aims to test whether abelacimab, a dual-acting FXI and activated FXI (FXIa) monoclonal antibody, is effective in halting clot formation and downstream growth when administered before or during active clot formation in an established baboon femoral arterio-venous (AV) shunt model. Methods: Three

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11

Eriksen, Rasmus Skytte, Sine L. Svenningsen, Kim Sneppen, and Namiko Mitarai. "A growing microcolony can survive and support persistent propagation of virulent phages." Proceedings of the National Academy of Sciences 115, no. 2 (2017): 337–42. http://dx.doi.org/10.1073/pnas.1708954115.

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Bacteria form colonies and secrete extracellular polymeric substances that surround the individual cells. These spatial structures are often associated with collaboration and quorum sensing between the bacteria. Here we investigate the mutual protection provided by spherical growth of a monoclonal colony during exposure to phages that proliferate on its surface. As a proof of concept we exposed growing colonies of Escherichia coli to a virulent mutant of phage P1. When the colony consists of less than ∼50,000 members it is eliminated, while larger initial colonies allow long-term survival of b

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12

Nasser, Roudaina, Mireia Pelegrin, Henri-Alexandre Michaud, Marc Plays, Marc Piechaczyk, and Laurent Gros. "Long-Lasting Protective Antiviral Immunity Induced by Passive Immunotherapies Requires both Neutralizing and Effector Functions of the Administered Monoclonal Antibody." Journal of Virology 84, no. 19 (2010): 10169–81. http://dx.doi.org/10.1128/jvi.00568-10.

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ABSTRACT Using FrCasE retrovirus-infected newborn mice as a model system, we have shown recently that a long-lasting antiviral immune response essential for healthy survival emerges after a short treatment with a neutralizing (667) IgG2a isotype monoclonal antibody (MAb). This suggested that the mobilization of adaptive immunity by administered MAbs is key for the success in the long term for the MAb-based passive immunotherapy of chronic viral infections. We have addressed here whether the anti-FrCasE protective endogenous immunity is the mere consequence of viral propagation blunting, which

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13

Hiatt, Andrew, Larry Zeitlin, and Kevin J. Whaley. "Multiantibody Strategies for HIV." Clinical and Developmental Immunology 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/632893.

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Vaccination strategies depend entirely on the appropriate responsiveness of our immune system against particular antigens. For this active immunization to be truly effective, neutralizing antibodies (nAbs) need to efficiently counter the infectivity or propagation of the pathogen. Some viruses, including HIV, are able to take advantage of this immune response in order to evade nAbs. This review focuses on viral immune evasion strategies that result directly from a robust immune response to infection or vaccination. A rationale for multi-Ab therapy to circumvent this phenomenon is discussed. Pr

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14

Velez, Daniel, Llonas Miller, and James D. Macmillan. "Use of tangential flow filtration in perfusion propagation of hybridoma cells for production of monoclonal antibodies." Biotechnology and Bioengineering 33, no. 7 (1989): 938–40. http://dx.doi.org/10.1002/bit.260330721.

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Wong, J. T., C. E. Pinto, J. D. Gifford, J. T. Kurnick, and R. L. Kradin. "Characterization of the CD4+ and CD8+ tumor infiltrating lymphocytes propagated with bispecific monoclonal antibodies." Journal of Immunology 143, no. 10 (1989): 3404–11. http://dx.doi.org/10.4049/jimmunol.143.10.3404.

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Abstract To study the CD4+ and CD8+ tumor infiltrating lymphocytes (TIL) in the antitumor response, we propagated these subsets directly from tumor tissues with anti-CD3:anti-CD8 (CD3,8) and anti-CD3:anti-CD4 (CD3,4) bispecific mAb (BSMAB). CD3,8 BSMAB cause selective cytolysis of CD8+ lymphocytes by bridging the CD8 molecules of target lymphocytes to the CD3 molecular complex of cytolytic T lymphocytes with concurrent activation and proliferation of residual CD3+CD4+ T lymphocytes. Similarly, CD3,4 BSMAB cause selective lysis of CD4+ lymphocytes whereas concurrently activating the residual CD

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16

Donofrio, Gaetano, Frank L. Heppner, Magdalini Polymenidou, Christine Musahl, and Adriano Aguzzi. "Paracrine Inhibition of Prion Propagation by Anti-PrP Single-Chain Fv Miniantibodies." Journal of Virology 79, no. 13 (2005): 8330–38. http://dx.doi.org/10.1128/jvi.79.13.8330-8338.2005.

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ABSTRACT Prion diseases are characterized by the deposition of PrPSc, an abnormal form of the cellular prion protein PrPC. A growing body of evidence suggests that antibodies to PrPC can antagonize deposition of PrPSc. However, host tolerance hampers the induction of immune responses to PrPC, and cross-linking of PrPC by bivalent anti-PrP antibodies is neurotoxic. In order to obviate these problems, we explored the antiprion potential of recombinant single-chain antibody (scFv) fragments. scFv fragments derived from monoclonal anti-PrP antibody 6H4, flagged with c-myc and His6 tags, were corre

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17

Hansson, Ulrika. "In Vitro Versus In Vivo Propagation of Monoclonal Antibodies: A Test Case for the Effectiveness of Swedish Ethical Review Committees." Alternatives to Laboratory Animals 25, no. 5 (1997): 517–26. http://dx.doi.org/10.1177/026119299702500508.

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In descriptions of the Swedish system for the control of animal experiments, it is often implied that the system guarantees that the animals are not subjected to unnecessary suffering and that available alternative methods are used. A study was carried out to examine applications for the use of the ascites method for monoclonal antibody production during 1995 and 1996. The data show that approval was given to all the applications received, with scanty justification. Thus, public reassurance that the Swedish system prevents the unnecessary use of animals is undermined by these findings.

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18

Zhang, Shi-Jun, Dan Su, Shi-Bo Zhao, et al. "Isolation, Identification, and Genetic Evolution Analysis of VP1 Gene of Feline Calicivirus Strain ZZ202306." International Journal of Molecular Sciences 26, no. 6 (2025): 2565. https://doi.org/10.3390/ijms26062565.

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This study investigated a suspected Feline calicivirus (FCV) outbreak at a veterinary facility in Zhengzhou, Henan Province, China. RT-PCR analysis confirmed the FCV presence, with subsequent CRFK cell culture propagation leading to the isolation and characterization of strain ZZ202306. Immunofluorescence and Western blot analyses validated the specificity of monoclonal antibodies targeting the FCV VP1 capsid protein. Transmission electron microscopy revealed non-enveloped virions of ~40 nm in diameter, exhibiting typical caliciviral architecture. Viral replication kinetics demonstrated expone

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19

Miyamoto, Kazuyoshi, Naoto Nakamura, Masayoshi Aosasa, et al. "Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein." Biochemical and Biophysical Research Communications 335, no. 1 (2005): 197–204. http://dx.doi.org/10.1016/j.bbrc.2005.07.063.

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Kumar, Satendra, and Himanshi Gupta. "Recent Development of Anticancer Agents." Journal of Phytopharmacology 11, no. 1 (2022): 17–23. http://dx.doi.org/10.31254/phyto.2022.11104.

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Cancer is the unwanted growth of the cell, which is developed trillion of the cells. It may be either Cancerous or Non-Cancerous. The aetiology involves the propagation of Cancer, defective DNA, or Mutation in DNA because of distinct Factors (Physical, Chemical, Biology, and Others). There is various kind of cancer (such as Carcinoma, Sarcoma, Myeloma, leukaemia and Lymphoma etc.). The sign and symptoms involve in Cancer (Such fever, loss of appetite, weight loss, thickening or lump in the body and unusual upset stomach or difficulty and swelling). Now a days the treatment is used in treatment

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21

Fassler, Michael, Clara Benaim, and Jacob George. "TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration." Cells 12, no. 11 (2023): 1549. http://dx.doi.org/10.3390/cells12111549.

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TREM2 is a membrane receptor expressed on microglia that plays a pivotal role in the organization and function of these innate immune cell components within the neurodegenerated brain. Whereas TREM2 deletion has been studied extensively in experimental beta-amyloid and Tau-based models of Alzheimer’s disease, its engagement, and subsequent agonism have not been tested in the context of Tau pathology. Herein, we explored the effects of Ab-T1, an agonistic TREM2 monoclonal antibody on Tau uptake, phosphorylation, seeding, and spreading as well as its therapeutic efficacy in a Tauopathy model. Ab

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Hromadkova, Lenka, Chae Kim, Tracy Haldiman, et al. "Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer’s disease." PLOS Pathogens 21, no. 6 (2025): e1012926. https://doi.org/10.1371/journal.ppat.1012926.

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Deposits of misfolded tau proteins are leading indicators of cognitive decline in Alzheimer’s disease (AD), and our recent data implicate distinctly misfolded conformers of the tau protein with high seeding potency in rapid progression. We considered prion-like templated propagation of misfolding in neurons as an underlying mechanism and derived sensitive conformational assays to test this concept and identify critical structural drivers. Using novel photochemical hydroxylation monitored with a panel of Europium-labeled monoclonal antibodies, we investigated the structural organization of diff

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Wescott, Melanie P., Irina Kufareva, Cheryl Paes, et al. "Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices." Proceedings of the National Academy of Sciences 113, no. 35 (2016): 9928–33. http://dx.doi.org/10.1073/pnas.1601278113.

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The atomic-level mechanisms by which G protein-coupled receptors (GPCRs) transmit extracellular ligand binding events through their transmembrane helices to activate intracellular G proteins remain unclear. Using a comprehensive library of mutations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino acids that are required for signaling induced by the chemokine ligand CXCL12 (stromal cell-derived factor 1). CXCR4 variants with each of these mutations do not signal properly but remain folded, based on receptor surface trafficking, reactivity to confor

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Gros, Laurent, Hanna Dreja, Anne Laure Fiser, Marc Plays, Mireia Pelegrin, and Marc Piechaczyk. "Induction of Long-Term Protective Antiviral Endogenous Immune Response by Short Neutralizing Monoclonal Antibody Treatment." Journal of Virology 79, no. 10 (2005): 6272–80. http://dx.doi.org/10.1128/jvi.79.10.6272-6280.2005.

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ABSTRACT Long-term immune control of viral replication still remains a major challenge in retroviral diseases. Several monoclonal antibodies (MAbs) have already shown antiviral activities in vivo, including in the clinic but their effects on the immune system of treated individuals are essentially unknown. Using the lethal neurodegeneration induced in mice upon infection of neonates by the FrCasE retrovirus as a model, we report here that transient treatment by a neutralizing MAb shortly after infection can, after an immediate antiviral effect, favor the development of a strong protective host

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Johnston, Ian, Amrita Sarkar, Vincent Hayes, et al. "Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation." Blood 135, no. 15 (2020): 1270–80. http://dx.doi.org/10.1182/blood.2018881607.

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Abstract Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by complexes between platelet factor 4 (PF4) and heparin or other polyanions, but the risk of thrombosis extends beyond exposure to heparin implicating other PF4 partners. We recently reported that peri-thrombus endothelium is targeted by HIT antibodies, but the binding site(s) has not been identified. We now show that PF4 binds at multiple discrete sites along the surface of extended strings of von Willebrand factor (VWF) released from the endothelium following photochemical injury in an endothelialized micro

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Gibbs, Ebrima, Beibei Zhao, Andrei Roman, et al. "Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein." Biomedicines 10, no. 9 (2022): 2168. http://dx.doi.org/10.3390/biomedicines10092168.

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Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and soluble fibrils have been shown to mediate neurotoxicity and cell-to-cell propagation of pathology. To generate antibodies capable of selectively targeting pathogenic forms of α-Syn, computational modeling was used to predict conformational epitopes likely to become exposed on oligomers and small soluble fibrils, but not on monomers or fully formed insoluble

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Feng, Xiaochuan, Donna E. Akiyoshi, Abhineet Sheoran, et al. "Serial Propagation of the Microsporidian Enterocytozoon bieneusi of Human Origin in Immunocompromised Rodents." Infection and Immunity 74, no. 8 (2006): 4424–29. http://dx.doi.org/10.1128/iai.00456-06.

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ABSTRACT Enterocytozoon bieneusi, a microsporidian, is clinically one of the most significant opportunistic causes of diarrhea and wasting associated with profound human immunodeficiencies. The lack of an animal model for E. bieneusi hinders serious investigations and limits the availability of spores to individuals with severe human immunodeficiency virus/AIDS disease who are infected with E. bieneusi. The development of procedures for purification and concentration of spores from stools of infected humans has led to the production of immune reagents and provided a source of spores to conduct

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Pelegrin, Mireia, Soledad Marsile-Medun, Daouda Abba-Moussa, Manon Souchard, and Mar Naranjo-Gomez. "Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses." Antibodies 11, no. 3 (2022): 50. http://dx.doi.org/10.3390/antib11030050.

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The multiple mechanisms of action of antiviral monoclonal antibodies (mAbs) have made these molecules a potential therapeutic alternative for treating severe viral infections. In addition to their direct effect on viral propagation, several studies have shown that mAbs are able to enhance the host’s adaptive immune response and generate long-lasting protective immunity. Such immunomodulatory effects occur in an Fc-dependent manner and rely on Fc-FcγR interactions. It is noteworthy that several FcγR-expressing cells have been shown to play a key role in enhancing humoral and cellular immune res

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May, Janet S., Jennifer Walker, Susanna Colaco, and Philip G. Stevenson. "The Murine Gammaherpesvirus 68 ORF27 Gene Product Contributes to Intercellular Viral Spread." Journal of Virology 79, no. 8 (2005): 5059–68. http://dx.doi.org/10.1128/jvi.79.8.5059-5068.2005.

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ABSTRACT Herpesviruses remain predominantly cell associated within their hosts, implying that they spread between cells by a mechanism distinct from free virion release. We previously identified the efficient release of murine gammaherpesvirus 68 (MHV-68) virions as a function of the viral gp150 protein. Here we show that the MHV-68 ORF27 gene product, gp48, contributes to the direct spread of viruses from lytically infected to uninfected cells. Monoclonal antibodies to gp48 identified it on infected cell surfaces and in virions. gp48-deficient viruses showed no obvious deficit in virion cell

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Okada, Noriko, Xiaoshan Wu, Masashi Mizokami, Reiko F. Irie, and Hidechika Okada. "Human IgM Monoclonal Antibody to Ganglioside GM2 and Complement Suppress Virus Propagation inEx VivoCultures of Lymphocytes from HIV-1 Infected Patients." Microbiology and Immunology 43, no. 7 (1999): 723–27. http://dx.doi.org/10.1111/j.1348-0421.1999.tb02462.x.

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Freire, E. "The propagation of binding interactions to remote sites in proteins: Analysis of the binding of the monoclonal antibody D1.3 to lysozyme." Proceedings of the National Academy of Sciences 96, no. 18 (1999): 10118–22. http://dx.doi.org/10.1073/pnas.96.18.10118.

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Amsterdam, E. A., G. L. Stahl, H. L. Pan, S. V. Rendig, M. P. Fletcher, and J. C. Longhurst. "Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 1 (1995): H448—H457. http://dx.doi.org/10.1152/ajpheart.1995.268.1.h448.

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The complement system has been implicated in reperfusion injury during acute myocardial infarction. We therefore attempted to reduce reperfusion injury with a monoclonal antibody (MAb) to the complement component, C5a. In 13 control pigs and 9 pigs pretreated with this MAb, ischemia was induced by a 50-min occlusion of the left anterior descending coronary artery, followed by 3 h of reperfusion. Infarct area (as percent of risk area) was reduced from 58 +/- 5% in controls to 38 +/- 7% (P < 0.05) in MAb-treated animals. Heart rate-systolic blood pressure product, left ventricular (LV) first

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S. Haidar, Ziyad. "Oncolytic Viruses: From Basics to Challenges to Innovation." Innovation Discovery 1, no. 3 (2024): 27. http://dx.doi.org/10.53964/id.2024027.

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The landscape of cancer therapeutics has undergone a transformative shift from broad approaches, such as radiation and chemotherapy, to more precise strategies, encompassing small molecule kinase inhibitors and monoclonal antibodies targeting immune checkpoint molecules. Oncolytic viruses (OVs) have recently emerged as a promising and viable option for cancer immunotherapy, particularly for “cold” tumors entrenched in an immunologically-suppressive tumor microenvironment. Genetic attenuation refines the characteristics of OVs, replacing specific genes to enhance conditional viral replication w

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Mallory, Michael, Lisa Lindesmith, Rachel Graham, and Ralph Baric. "GII.4 Human Norovirus: Surveying the Antigenic Landscape." Viruses 11, no. 2 (2019): 177. http://dx.doi.org/10.3390/v11020177.

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Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need for inducible immunity, as symptomatic dehydration and malnutrition can be lethal. Extensive antigenic diversity between genotypes and within the GII.4 genotype present major challenges for the development of a broadly protective vaccine. Efforts have been devoted to characterizing antibody-binding interactions with dynamic human norovirus vir

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Konopleva, Marina, Zeev Estrov, Shourong Zhao, Michael Andreeff, and Kapil Mehta. "Ligation of Cell Surface CD38 Protein with Agonistic Monoclonal Antibody Induces a Cell Growth Signal in Myeloid Leukemia Cells." Journal of Immunology 161, no. 9 (1998): 4702–8. http://dx.doi.org/10.4049/jimmunol.161.9.4702.

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Abstract CD38 is expressed during early stages of differentiation in normal and leukemic myeloid cells. Recently, CD38 has been shown to participate in intracellular signal transduction pathways following its ligation with CD38-specific mAbs. In this study we report that ligation of CD38 by one such agonistic mAb (IB4) induced proliferation of cultured leukemic cells in vitro. In HL-60, KG-1A, NB4, and OCI-AML-3 myeloid leukemia cell lines, IB4 mAb induced an increase in the proliferating cell fraction as determined by cell number, clonogenic assay, and flow cytometric analysis. The presence o

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Fujisawa, Haruo. "Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice." Journal of Virology 82, no. 6 (2008): 2772–83. http://dx.doi.org/10.1128/jvi.01210-07.

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ABSTRACT The role of polymorphonuclear leukocytes (PMN) in protection in the early phase and recovery in the late phase of influenza A virus infection was investigated by the depletion of PMN in, and passive transfer of anti-influenza virus antiserum to, mice with pulmonary infections. The depletion of PMN in normal mice by treatment with monoclonal antibody RB6-8C5 both increased the mortality rate and pulmonary virus titers from the early to the late phase after infection and delayed virus elimination in the late phase. The passive transfer of the antiserum to normal mice before or after inf

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Hoffman, Rebecca M., Marilyn M. Marshall, David M. Polchert, and B. Helen Jost. "Identification and Characterization of Two Subpopulations of Encephalitozoon intestinalis." Applied and Environmental Microbiology 69, no. 8 (2003): 4966–70. http://dx.doi.org/10.1128/aem.69.8.4966-4970.2003.

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ABSTRACT Microsporidia are obligate intracellular protozoa that have been shown to be pathogenic to most living creatures. The development of in vitro cell culture propagation methods has provided researchers with large numbers of spores and facilitated the study of these organisms. Here, we describe heterogeneity within cell culture-propagated Encephalitozoon intestinalis suspensions. Flow cytometer histograms depicting the log side scatter and forward-angle light scatter of spores from nine suspensions produced over 12 months consistently showed two populations differing in size. The suspens

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Dea, S., R. Bilodeau, R. Sauvageau, C. Montpetit, and G. P. Martineau. "Antigenic Variant of Swine Influenza Virus Causing Proliferative and Necrotizing Pneumonia in Pigs." Journal of Veterinary Diagnostic Investigation 4, no. 4 (1992): 380–92. http://dx.doi.org/10.1177/104063879200400403.

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A new antigenic variant of swine influenza virus was isolated from the lungs of pigs experiencing respiratory problems in 7 different swine herds in Quebec. Pigs of different ages were affected, and the main clinical signs were fever, dyspnea, and abdominal respiration. Coughing was not a constant finding of the syndrome. At necropsy, macroscopic lesions included the overall appearance of pale animals, general lymphadenopathy, hepatic congestion, and consolidation of the lungs. Histopathologic findings were mainly proliferative pneumonia with a significant macrophage invasion, necrotic inflamm

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Taylor, Aimee R., Diego F. Echeverry, Timothy J. C. Anderson, Daniel E. Neafsey, and Caroline O. Buckee. "Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast." PLOS Genetics 16, no. 11 (2020): e1009101. http://dx.doi.org/10.1371/journal.pgen.1009101.

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Characterising connectivity between geographically separated biological populations is a common goal in many fields. Recent approaches to understanding connectivity between malaria parasite populations, with implications for disease control efforts, have used estimates of relatedness based on identity-by-descent (IBD). However, uncertainty around estimated relatedness has not been accounted for. IBD-based relatedness estimates with uncertainty were computed for pairs of monoclonal Plasmodium falciparum samples collected from five cities on the Colombian-Pacific coast where long-term clonal pro

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Bouterige, Sandrine, Guy Tronchin, Maurice Lesourd, et al. "Ultrastructural and Immunochemical Changes During the In Vitro Development of Plasmopara halstedii." Phytopathology® 93, no. 8 (2003): 1023–30. http://dx.doi.org/10.1094/phyto.2003.93.8.1023.

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The asexual phase of the life cycle of Plasmopara halstedii, the causal agent of downy mildew of sunflower, plays a key role in the propagation of the disease. We investigated the morphological and ultrastructural changes that occur during the asexual development of the pathogen. Direct examination of infected cotyledons confirmed the presence of sporangiophores. In contact with water, important ultrastructural changes occurred, affecting the surface of zoosporangia, which became smoother, and their cytoplasm, which differentiated into flagellate zoospores. The subsequent encystment of zoospor

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Gagnon, C., D. White, P. Huitorel, and J. Cosson. "A monoclonal antibody against the dynein IC1 peptide of sea urchin spermatozoa inhibits the motility of sea urchin, dinoflagellate, and human flagellar axonemes." Molecular Biology of the Cell 5, no. 9 (1994): 1051–63. http://dx.doi.org/10.1091/mbc.5.9.1051.

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To investigate the role of axonemal components in the mechanics and regulation of flagellar movement, we have generated a series of monoclonal antibodies (mAb) against sea urchin (Lytechinus pictus) sperm axonemal proteins, selected for their ability to inhibit the motility of demembranated sperm models. One of these antibodies, mAb D1, recognizes an antigen of 142 kDa on blots of sea urchin axonemal proteins and of purified outer arm dynein, suggesting that it acts by binding to the heaviest intermediate chain (IC1) of the dynein arm. mAb D1 blocks the motility of demembranated sea urchin spe

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Naranjo-Gomez, Mar, Marine Cahen, Jennifer Lambour, Myriam Boyer-Clavel, and Mireia Pelegrin. "Immunomodulatory Role of NK Cells during Antiviral Antibody Therapy." Vaccines 9, no. 2 (2021): 137. http://dx.doi.org/10.3390/vaccines9020137.

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Monoclonal antibodies (mAbs) are now considered as a therapeutic approach to prevent and treat severe viral infections. Using a mouse retroviral model, we showed that mAbs induce protective immunity (vaccinal effects). Here, we investigated the role of natural killer (NK) cells on this effect. NK cells are effector cells that are crucial to control viral propagation upon mAb treatment. However, their immunomodulatory activity during antiviral mAb immunotherapies has been little studied. Our data reveal that the mAb treatment of infected mice preserves the functional activation of NK cells. Imp

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Steininger, Christoph, George F. Widhopf, Emanuela M. Ghia, et al. "Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen." Blood 119, no. 10 (2012): 2293–301. http://dx.doi.org/10.1182/blood-2011-08-374058.

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AbstractLeukemia cells from patients with chronic lymphocytic leukemia (CLL) express a highly restricted immunoglobulin heavy variable chain (IGHV) repertoire, suggesting that a limited set of antigens reacts with leukemic cells. Here, we evaluated the reactivity of a panel of different CLL recombinant antibodies (rAbs) encoded by the most commonly expressed IGHV genes with a panel of selected viral and bacterial pathogens. Six different CLL rAbs encoded by IGHV1-69 or IGHV3-21, but not a CLL rAb encoded by IGHV4-39 genes, reacted with a single protein of human cytomegalovirus (CMV). The CMV p

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Gorby, G. L. "Digital confocal microscopy allows measurement and three-dimensional multiple spectral reconstruction of Neisseria gonorrhoeae/epithelial cell interactions in the human fallopian tube organ culture model." Journal of Histochemistry & Cytochemistry 42, no. 3 (1994): 297–306. http://dx.doi.org/10.1177/42.3.7508470.

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A strategy for measuring Neisseria gonorrhoeae attachment and invasion in the human Fallopian tube organ culture (FTOC) model via computerized image analysis (CIA) combined with "digital" confocal microscopy (DCM) was tested. DCM on serial image stacks of fluorescent latex beads reduced out-of-focus light propagation in the Z-axis (p < 0.005) and improved the shape factor of lateral three-dimensional reconstructions of the beads (p < 0.001). Sections of tissue infected for 44 hr with piliated, Opa+ gonococci were stained with fluorescein-labeled monoclonal anti-gonococcal antibodies, rho

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Samitas, Konstantinos, Vasiliki Delimpoura, Eleftherios Zervas, and Mina Gaga. "Anti-IgE treatment, airway inflammation and remodelling in severe allergic asthma: current knowledge and future perspectives." European Respiratory Review 24, no. 138 (2015): 594–601. http://dx.doi.org/10.1183/16000617.00001715.

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Asthma is a disorder of the airways involving various inflammatory cells and mediators and characterised by bronchial hyperresponsiveness, chronic inflammation and structural alterations in the airways, also known as remodelling. IgE is an important mediator of allergic reactions and has a central role in allergic asthma pathophysiology, as it is implicated in both the early and late phase allergic response. Moreover, clinical and mechanistic evidence has lately emerged, implicating IgE in the development of airway remodelling. The use of monoclonal antibodies targeting IgE, such as omalizumab

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Tucker, Erik I., Ulla M. Marzec, Tara C. White, et al. "Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI." Blood 113, no. 4 (2009): 936–44. http://dx.doi.org/10.1182/blood-2008-06-163675.

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Abstract The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor XI (FXI)–dependent thrombus growth remains unclear, we investigated the contribution of FXI to thrombus formation in a primate thrombosis model. Pretreatment of baboons with a novel anti–human FXI monoclonal antibody (aXIMab; 2 mg/kg) inhibited plasma FXI by at least 99% for 10 days, and suppressed thrombin-antithrombin (TAT) complex and β-thromboglobulin (βTG) formation measured immediately downstream from thrombi forming within collagen-coated vascular gra

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Kim, Chan-Lan, Ayako Karino, Naotaka Ishiguro, Morikazu Shinagawa, Motoyoshi Sato, and Motohiro Horiuchi. "Cell-surface retention of PrPC by anti-PrP antibody prevents protease-resistant PrP formation." Journal of General Virology 85, no. 11 (2004): 3473–82. http://dx.doi.org/10.1099/vir.0.80113-0.

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The C-terminal portion of the prion protein (PrP), corresponding to a protease-resistant core fragment of the abnormal isoform of the prion protein (PrPSc), is essential for prion propagation. Antibodies to the C-terminal portion of PrP are known to inhibit PrPSc accumulation in cells persistently infected with prions. Here it was shown that, in addition to monoclonal antibodies (mAbs) to the C-terminal portion of PrP, a mAb recognizing the octapeptide repeat region in the N-terminal part of PrP that is dispensable for PrPSc formation reduced PrPSc accumulation in cells persistently infected w

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Huang, Yingni, Yang Li, Kunkun Zou, et al. "The Resistance of Maize to Ustilago maydis Infection Is Correlated with the Degree of Methyl Esterification of Pectin in the Cell Wall." International Journal of Molecular Sciences 24, no. 19 (2023): 14737. http://dx.doi.org/10.3390/ijms241914737.

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Common smut caused by Ustilago maydis is one of the dominant fungal diseases in plants. The resistance mechanism to U. maydis infection involving alterations in the cell wall is poorly studied. In this study, the resistant single segment substitution line (SSSL) R445 and its susceptible recurrent parent line Ye478 of maize were infected with U. maydis, and the changes in cell wall components and structure were studied at 0, 2, 4, 8, and 12 days postinfection. In R445 and Ye478, the contents of cellulose, hemicellulose, pectin, and lignin increased by varying degrees, and pectin methylesterase

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Xiao, Li, Ai-Qun Hu, Mei-Na Wang, et al. "Monoclonality and Low Genetic Diversity in Vanilla shenzhenica: Highlighting Urgent Need for Genetic Preservation of China’s Only Endangered Vanilla." International Journal of Molecular Sciences 26, no. 7 (2025): 3451. https://doi.org/10.3390/ijms26073451.

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Long-term clonality has profound consequences for genetic structure despite offering an alternative means of reproductive assurance under unfavorable conditions for sexual reproduction. Vanilla shenzhenica Z. J. Liu & S. C. Chen (Orchidaceae), the only endangered Vanilla species in China, exhibits a clear tendency towards asexual propagation, as evidenced by its small, fragmented wild populations. To develop effective conservation strategies for this species, it is essential to assess the extent of clonality and evaluate genetic diversity both within and among populations. In this study, w

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Bjerkvig, Rolf, Audun Tønnesen, Ole Didrik Laerum, and Erik-Olof Backlund. "Multicellular tumor spheroids from human gliomas maintained in organ culture." Journal of Neurosurgery 72, no. 3 (1990): 463–75. http://dx.doi.org/10.3171/jns.1990.72.3.0463.

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✓ Tumor tissue from seven human gliomas was maintained in long-term agar overlay culture as multicellular organotypic spheroids. Light microscopic and ultrastructural observation of the spheroids displayed morphological features similar to those of the original tumor tissue in vivo; in this respect they were different from spheroids obtained from permanent cell lines. The spheroids contained preserved vessels, connective tissue, and macrophages, revealing a close resemblance to the conditions in the original tumor. Flow cytometric deoxyribonucleic acid measurements of cells from the tumor sphe

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