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Rozprawy doktorskie na temat „Mouth disease”

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Data publikacji: 3 czerwca 2025

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1

Nayak, Arabinda. "Foot and mouth disease virus RNA replication." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/842873/.

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Infection of susceptible cells with foot and mouth disease virus (FMDV) results in multiplication of the RNA genome and assembly of mature virions. The entire process of genome replication is completed in a few hours and encompasses many intracellular events. Like other picornaviruses, FMDV uses a peptide primed RNA replication mechanism. The factors that are required to uridylylate each of the three FMDV VPg peptides and the role of the FMDV cis-acting replication element (cre) or 3B Uridylylation Site (bus) in VPg uridylylation have been determined. The native N-terminus of the FMDV 3Dpol en

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2

Foster-Cuevas, Mildred. "Immunodeterminants of foot-and-mouth disease virus." Thesis, University of Hertfordshire, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338562.

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3

Puig, Arturo. "Lipopeptide vaccines against foot and mouth disease." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428103.

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Tsang, Chiu-shun Peter. "Oral biology of human immunodeficiency virus-infected individuals in Hong Kong /." [Hong Kong : Faculty of Dentistry, University of Hong Kong], 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19900661.

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5

Cottam, Eleanor Myfanwy. "Micro-evolution of foot-and-mouth disease virus." Thesis, Connect to e-thesis. Move to record for print version, 2008. http://theses.gla.ac.uk/92/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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6

Lea, Susan Mary. "Structural studies on foot-and-mouth disease virus." Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:438dc0ae-b899-40fd-84dc-03d3fc1a537f.

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Foot-and-mouth disease viruses (FMDVs) constitute the aphthovirus genus of the Picornaviridae. The structures of Oi subtype viruses OiK and G67 have been solved and comparisons reveal the structural basis of monoclonal antibody escape mutations in G67. Escape mutations are seen to occur at surface-exposed residues and to provoke structural changes limited to the altered side chains. Comparisons of the structures of O<sub>1</sub> and O<sub>1</sub>BFS (Acharya et al., Nature 337, 709-716 (1989)) suggest that changes occurring 'in-the-field' in response to polyclonal antibody pressure may be subt

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7

Yiu, Kar-yung Cynthia. "Evaluation of interdental cleaning in adolescents and young adults in Hong Kong." Hong Kong : University of Hong Kong, 1989. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12556518.

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8

Chen, Shih-Ping. "Epidemiology, pathogenesis and surveillance of pig adapted strain of foot and mouth disease in Taiwan /." Murdoch University Digital Theses Program, 2008. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20080813.104029.

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9

Edacheril, Mathew. "Assessment of herd immunity to foot-and-mouth disease." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314315.

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10

Mahdi, Ali Jafar. "Foot and mouth disease in Iraq: strategy and control." Kansas State University, 2010. http://hdl.handle.net/2097/4620.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Gary A. Anderson<br>Foot-and-mouth disease (FMD) is a highly infectious viral disease of cattle, pigs, sheep, goats, buffalo, and artiodactyl wildlife species. Foot-and-mouth disease virus is endemic and periodic devastating epidemics have occurred and caused heavy economic losses in Iraq for a long time. The first official cases of FMD were recorded in 1937, while the first record of a specific FMD serotype in Iraq was serotype A in 1952. Other serotypes have been reported since then; serotypes O, SAT-1 and Asia1 were

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11

Будаєва, І. В., та Г. О. Ревенко. "Hand-foot-and-mouth disease (HFMD) у Дніпропетровському регіоні". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64722.

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Ентеровірусний везикулярний стоматит з екзантемою (Hand-Foot-and-Mouth Disease (HFMD)) - захворювання, що перебігає з ураженням шкіри кистей і стоп, слизової оболонки порожнини рота. Ентеровіруси мають тропність до нервової та серцево-судинної системи.<br>Clinical and epidemiological particularities of HFMD in children are presented. Considering cardiotropic features enteroviruses ECG and CFK-MB are evaluated in 14 children. Signs of myocarditis are revealed.

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12

Ramanoon, Siti. "The epidemiology of foot and mouth disease in Malaysia." Thesis, Ramanoon, Siti (2016) The epidemiology of foot and mouth disease in Malaysia. PhD thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/32386/.

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The objectives of the present study were to determine the prevalence of foot and mouth disease (FMD) and the serotypes of foot and mouth disease virus (FMDV) in Malaysia; to describe the temporal and spatial distribution of FMD in Malaysia; to evaluate the risk of the introduction of FMD to Malaysia; to evaluate the effectiveness of mitigation strategies adopted in Malaysia during outbreaks of FMD; and ultimately to give recommendations on FMD control to the Malaysia-Thailand-Myanmar (MTM) Tri-state Commission and Zoning Working Groups. The first documented outbreak of FMD in Peninsular Ma

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13

Howes, Emma Louise. "Investigating the foot-and-mouth disease virus 3A protein." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/15521.

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Foot-and-Mouth Disease Virus (FMDV) is a globally important pathogen responsible for causing Foot-and-Mouth Disease (FMD) in wildlife and domestic livestock species and has significant economic impacts. FMD is difficult to control due to its highly infectious nature, wide diversity of host species and the existence of multiple serotypes; therefore, understanding the processes of FMDV infection and viral RNA replication are key to the development of improved diagnostics and vaccines. This thesis investigates the potential roles of the FMDV 3A non-structural protein using a combination of sub-ge

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14

Sahle, Mesfin. "An epidemiological study on the genetic relationships of foot and mouth disease viruses in East Africa." Pretoria : [s.n.], 2010. http://upetd.up.ac.za/thesis/available/etd-08132008-095346/.

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15

O'Connor, Steven Patrick. "The production of foot-and-mouth disease virus-like particles in the plant Nicotiana benthamiana: a potential candidate vaccine for foot-and-mouth disease." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29378.

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Foot and mouth disease virus (FMDV) infects cloven-hoofed animals causing the highly contagious foot and mouth disease. It is spread by contact or through aerosol. The disease is often debilitating for infected animals and can be fatal. Severe measures are taken to contain outbreaks; quarantine and trade restrictions are imposed and herds with infected individuals are culled to prevent the spread of the disease. Consequently, outbreaks of the disease have drastic implications for agriculture and social economies which can be devastating for affected countries. There are seven serotypes of the

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16

Di, Nardo Antonello. "Phylodynamic modelling of foot-and-mouth disease virus sequence data." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7558/.

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The under-reporting of cases of infectious diseases is a substantial impediment to the control and management of infectious diseases in both epidemic and endemic contexts. Information about infectious disease dynamics can be recovered from sequence data using time-varying coalescent approaches, and phylodynamic models have been developed in order to reconstruct demographic changes of the numbers of infected hosts through time. In this study I have demonstrated the general concordance between empirically observed epidemiological incidence data and viral demography inferred through analysis of f

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17

Fry, Elizabeth Evelyn. "The three dimensional structure of foot and mouth disease virus." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281130.

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18

Bessell, Paul R. "Spatial epidemiology of Foot and Mouth Disease in Great Britain." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4831.

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During 2007 the UK experienced outbreaks of three notifiable exotic livestock diseases; Foot and Mouth Disease (FMD), Highly Pathogenic Avian Influenza (HPAI) and bluetongue. Large epidemics of any of these diseases would have a serious impact on animal welfare, farming, food production and the economy. In light of this, understanding holdings which are most likely to acquire and spread infection and being able to identify areas at higher risk of an epidemic is valuable when preparing for and managing an epidemic. This thesis uses a spatial epidemiological framework and the detailed disease an

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19

Jochimsen, Aaron A. "The vulnerability of U.S. agriculture to foot and mouth disease." Thesis, Monterey, California: Naval Postgraduate School, 2015. http://hdl.handle.net/10945/45881.

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Approved for public release; distribution is unlimited<br>The U.S. livestock industry represents a critical economic infrastructure, due to its size and influence on national and international agricultural systems. The high-concentration farming practices that allow the United States to be a world leader in agriculture also present a vulnerability to biological pathogens, particularly foot and mouth disease (FMD). The purpose of this thesis is to stimulate and broaden the discussion of the U.S. livestock industry’s susceptibility to an FMD outbreak, regardless of how it is introduced. It revie

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20

Abrams, Charles C. "The biosynthesis of foot-and-mouth disease virus empty capsids." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332255.

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21

Flint, Mike. "A study of foot-and-mouth disease virus polyprotein processing." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295238.

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22

Davidson, Freda Lynn. "Alternative strategies for foot-and-mouth disease control in pigs." Thesis, University of Hertfordshire, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361189.

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23

Ludi, Anna Barbara. "Antigenic variation of foot-and-mouth disease virus serotype A." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648211.

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24

Knight-Jones, Theo. "Field evaluation of foot-and-mouth disease vaccination in Turkey." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618321.

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25

Borley, Daryl W. "Epitope dominance studies with serotype O foot-and-mouth disease." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:4adc3373-1d89-41d9-b1ce-7d8cbb0e817a.

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Foot-and-mouth disease virus (FMDV) is an economically devastating and highly contagious livestock pathogen. It exists as seven serotypes, comprising numerous antigenically distinct subtypes. The large amount of antigenic heterogeneity has confounded attempts at developing broadly reactive vaccines. In order to overcome this issue the fundamentals of the interactions between the virus and the host humoral immune response must first be understood. Previous work in this area using monoclonal antibody (mAb) escape mutants has identified five antigenic sites for the O serotype and efforts have bee

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26

Chitray, Melanie. "Investigating potential factors affecting foot-and-mouth disease virus internalisation." Diss., University of Pretoria, 2008. http://hdl.handle.net/2263/30391.

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Foot-and-mouth disease (FMD) is a highly contagious disease caused by the FMD virus (FMDV) belonging to the Picornaviridae family. The virus affects cloven-hoofed animals and occurs as seven immunologically distinct serotypes where six of the seven serotypes occur in Africa. This fact, as well as the role of wildlife in virus maintenance, makes eradication and control of FMDV in Africa difficult. Thus, it is imperative to attain more information regarding the genetic diversity of FMD viruses prevalent on the African continent to further our knowledge of the virus as well as to enable better co

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27

Chitray, Melanie. "Investigating potential factors affecting foot-and-mouth disease virus internalization." Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-02192009-165513/.

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28

Hui, Kin-hi Raymond. "Molecular epidemiology of and vaccine development against foot-and-mouth disease virus in Hong Kong." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31548544.

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29

Ngu, Duy Nghia. "Epidemiology and dynamic of hand, foot and mouth disease in Vietnam." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT099/document.

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Ce travail a analysé tous les cas de HFMD déclarés à Hai Phong pendant l’épidémie de 2011 et 2012 qui a été la plus importante au Vietnam et la première enregistrée dans le nord du pays. Hai Phong a connu la plus forte incidence au Nord Vietnam. C’était donc un bon modèle pour étudier la dynamique de cette maladie sans interférence et reliquats de précédentes épidémies ou de patients immunoadaptés.La première section est consacrée à une revue de la littérature sur EV-A71 et les entérovirus. La seconde section est divisée en trois chapitres, chacun abordant un aspect spécifique du projet.Le pre

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30

Berryman, Stephen John. "Early events in cell entry by foot-and-mouth disease virus." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/842711/.

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The studies presented in this thesis demonstrate that foot-and-mouth disease virus (FMDV) infection mediated by the integrin ?v?6 takes place through clathrin-dependent endocytosis. Inhibition of clathrin-dependent endocytosis by sucrose treatment or transient expression of a dominant-negative version of AP180 inhibited virus entry and infection. Similarly, inhibition of endosomal acidification inhibited an early step in infection. Blocking endosomal acidification did not interfere with surface expression of alphavbeta6, virus binding to the cells, uptake of the virus into endosomes, or cytopl

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Wong, Yim-ping, and 黃艷萍. "Development of a subunit vaccine against foot-and-mouth disease virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221993.

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32

Hofner, Maureen Catherine. "A study of foot-and-mouth disease virus pathogenesis in cattle." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338844.

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Freire, Antonio de Padua. "Epidemiological studies of foot-and-mouth disease in Minas Gerais Brazil." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363661.

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McInerney, Gerald Michael. "Trans-encapsidation of capsid-defective foot-and-mouth disease virus replicons." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301929.

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35

Collen, Trevor. "T cell responses of cattle to foot-and-mouth disease virus." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293303.

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Ali, Shireen. "Origin of replication complexes during foot and mouth disease virus infection." Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302421.

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Salt, Jeremy Simon. "The immunology of foot and mouth disease virus persistence in cattle." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358299.

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38

Malik, Nayab. "Structural characterisation of the foot-and-mouth disease virus uncoating pathway." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1120387b-eeb1-4a66-a380-06cfe37c5a47.

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Foot-and-mouth disease virus is a single-stranded RNA virus that belongs to the genus aphthoviruses, in the family Picornaviridae, and causes disease in cloven-hoofed animals. It is one of the biggest hindrances to the international trade of animals and animal products in the world. The virus capsids readily dissociate into pentamers at acidic pH. While there have been several studies on enterovirus uncoating, this process is poorly-understood for aphthoviruses, and there are no published structures elucidating how FMDV undergoes this transformation to infect cells. Furthermore, there are no s

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39

Wright, Caroline Frances. "Dissecting the molecular basis of foot-and-mouth disease virus evolution." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4254/.

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Foot-and-mouth disease virus (FMDV) causes the most contagious transboundary disease of animals, affecting both wild and domestic cloven-hoofed animals. Similarly to other RNA viruses, FMDV is highly variable as a result of the inherent low fidelity of the viral RNA-dependent RNA polymerase. The accumulation of this variability and relatedness between FMDV sequences was used to provide evidence for modes of transmission (fomite) as well as a constant clock rate across two FMDV topotypes (~8.70 x 10-3 substitutions/site/year), during the 1967 UK FMD epidemic, using full genome consensus sequenc

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Quan, Melvyn. "Quantitative dynamics of foot-and-mouth disease virus infection in pigs." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/30663.

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The main objectives of this project were to provide an accurate quantitative description, and develop a mathematical model, of FMDV dynamics in infected pigs. Time-course studies were set up and the viral load in serum, nasal swabs and tissue samples were determined. Time after infection, mode of infection, inoculation dose and housing conditions were examined as possible determinants of viral load. Similar results were obtained from pigs infected with FMDV by the intravenous, intradermal or oro-nasal route. Initial models of the early viral dynamics of FMDV disagreed with the experimental dat

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41

Logan, Grace. "The molecular and genetic evolution of foot-and-mouth disease virus." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7877/.

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Foot-and-mouth disease virus (FMDV) (Family: Picornaviridae, Genus: Aphthovirus) is a significant global pathogen with extensive economic impact. FMDV has a low fidelity RNA-dependent RNA polymerase and lacks proof reading capability. This coupled with its relatively short generation time and large population sizes means it exists in a swarm of genetically closely related variants. The reservoir of diversity contained within this mutant spectrum allows the virus to adapt rapidly to new environments. Much of the previous work looking at virus evolution has focused on the consensus level genetic

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42

Sangare, Oumou. "Molecular epidemiology of foot-and-mouth disease virus in West Africa." Thesis, University of Pretoria, 2002. http://hdl.handle.net/2263/23010.

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The economy of West African countries is dependent mainly on agriculture. Livestock production is a vital source of providing dietary protein for the rapidly growing human population and it is therefore important to define strategies for controlling infectious diseases that are undermining the livestock industry. Although the foot-and-mouth disease (FMD) virus causes one of the most devastating economical diseases, it has been mainly ignored in West Africa due to low mortality rates in the face of other diseases that cause significant mortalities. This may explain the lack of interest for stud

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Sabanathan, Saraswathy. "Neurodevelopmental outcomes following severe hand foot and mouth disease in Vietnam." Thesis, Open University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699826.

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In 2011, more than 160 children died in an unprecedented outbreak of Hand foot and mouth disease (HFMD) in Vietnam, predominantly associated with enterovirus 71 (EV-A71). The occurrence of encephalitis outbreaks in children at vulnerable developmental stages raised concerns of long-term consequences. Limited retrospective outcome studies in the literature lack either a healthy comparison group or a locally validated neurodevelopmental assessment tool. Brain MRI retrospective observations identified stereotypical patterns of brainstem lesions predominantly in severe EV-A71 HFMD cases with confl

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Wong, Yim-ping. "Development of a subunit vaccine against foot-and-mouth disease virus /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21080161.

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Young, James Robert. "Change management for sustainable foot-and-mouth disease control in Cambodia." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17038.

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Foot-and-mouth disease (FMD) is endemic in Cambodia and severely impacts smallholder cattle farming households, hindering market development and trade opportunities, plus food security and poverty alleviation. To improve understanding of drivers that may enable adoption of FMD biosecurity measures, change management factors were examined, including motivation for change, resistance to change, knowledge management, cultural dimensions, systems theory and leadership. Knowledge, attitudes and practices surveys (KAP) found smallholder farmer baseline biosecurity was very low, with farmers regularl

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46

Senawi, Jamaliah. "Epidemiology of Foot and Mouth Disease in Cattle in Pahang, Malaysia." Thesis, Senawi, Jamaliah (2012) Epidemiology of Foot and Mouth Disease in Cattle in Pahang, Malaysia. Masters by Research thesis, Murdoch University, 2012. https://researchrepository.murdoch.edu.au/id/eprint/10695/.

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Foot-and-mouth disease (FMD) is one of the most contagious diseases of domestic and wild cloven-hoofed animals. The disease has a significant negative impact on the economy of affected countries through reduced livestock productivity and loss of markets. In Pahang, Malaysia a severe outbreak of FMD started in December 2003, after approximately 18 years of freedom from the disease. The FMDV strain O was identified as the cause of this outbreak. The study reported in this thesis focused on three areas of epidemiology of FMD and was designed to: determine the temporal and spatial distribution and

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47

Scott, Katherine Anne. "Improved stability of foot-and-mouth disease virus (FMDV) SAT2 capsid." Thesis, University of Pretoria, 2016. http://hdl.handle.net/2263/60130.

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The thermostability of vaccines is of crucial importance in Africa, where the logistical process to get the vaccine from the manufacturer to the animal may take months, and in many remote regions transport and storage is in the absence of a cold-chain. Vaccines with improved stability and less reliance on a cold-chain are needed and could improve the longevity of immune responses elicited in vaccinated animals. In South Africa, cattle in the vaccination zone neighbouring the Kruger National Park have to be vaccinated thrice annually because of declining antibody responses at three months

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48

Fraser, Michelle. "Systematics of the genus Candida; implications for understanding clinical presentation, mixed infection and antifungal treatment and the influence on strain maintenance and replacement during oral candidiasis in HIV-infected individuals /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phf8421.pdf.

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Sahle, Mesfin. "An epidemiological study on the genetic relationships of foot-and-mouth disease viruses in East Africa." Thesis, University of Pretoria, 2004. http://hdl.handle.net/2263/27222.

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Within East African countries many of the known infectious diseases of animals occur commonly and are poorly controlled. Foot-and-mouth disease (FMD) is one of the contagious viral diseases that has great impact on economic development both in terms of direct and indirect losses. The epidemiology of the disease is complex due to the presence of six of the seven serotypes and the presence of large numbers of both wild and domestic susceptible animals in the region. Decision-making to determine the importance of FMD control relative to the economic consequences and what FMD control strategies sh

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50

Lyons, N. A. "Foot-and-mouth disease in Kenya : epidemiology, disease impact and vaccine effectiveness on large-scale dairy farms." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2172943/.

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Foot-and-mouth disease (FMD) is endemic in Kenya where serotypes A, O, SAT1 and SAT2 are frequently encountered. Despite the importance of the dairy industry and the frequent reporting of disease, the epidemiology of FMD and field-based vaccine effectiveness has been poorly described in these endemic settings. Additionally, the disease impact has been inadequately characterised, despite the importance of such information when allocating scarce resources for animal health in national disease control strategies. The objectives of this doctoral thesis were to gain field experience of FMD in endem

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