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Artykuły w czasopismach na temat „Multiple-stage processes”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 11 lutego 2022

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1

MEIKRANTZ, D. H., S. B. MEIKRANTZ, and L. L. MACALUSO. "ANNULAR CENTRIFUGAL CONTACTORS FOR MULTIPLE STAGE EXTRACTION PROCESSES." Chemical Engineering Communications 188, no. 1 (October 2001): 115–27. http://dx.doi.org/10.1080/00986440108912900.

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Jearkpaporn, D., C. M. Borror, G. C. Runger, and D. C. Montgomery. "Process monitoring for mean shifts for multiple stage processes." International Journal of Production Research 45, no. 23 (December 2007): 5547–70. http://dx.doi.org/10.1080/00207540701325371.

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Zeng, Rong, Liang Huang, Jianjun Li, Hongwei Li, Hui Zhu, and Xiaoting Zhang. "Quantification of multiple softening processes occurring during multi-stage thermoforming of high-strength steel." International Journal of Plasticity 120 (September 2019): 64–87. http://dx.doi.org/10.1016/j.ijplas.2019.04.010.

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Imaizumi, Mitsuhiro, and Mitsutaka Kimura. "Multiple-Stage Policies for a Server System with Illegal Access." International Journal of Reliability, Quality and Safety Engineering 25, no. 04 (June 6, 2018): 1850016. http://dx.doi.org/10.1142/s021853931850016x.

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As the Internet technology has developed, the demands for the improvement of the reliability and security of the system connected with the Internet have increased. Although various services are performed on the Internet, illegal access on the Internet has become a problem in recent years. This paper formulates stochastic models for a system with illegal access. The server has the function of IDS, and illegal access is checked in multiple stages which consist of simple check, detailed check and dynamic check. We apply the theory of Markov renewal processes to a system with illegal access, and d

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Barad, Miryam, and Daniel Braha. "Control Limits for Multi-Stage Manufacturing Processes with Binomial Yield (Single and Multiple Production Runs)." Journal of the Operational Research Society 47, no. 1 (January 1996): 98. http://dx.doi.org/10.2307/2584255.

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Zhao, Chunhui, Fuli Wang, Ningyun Lu, and Mingxing Jia. "Stage-based soft-transition multiple PCA modeling and on-line monitoring strategy for batch processes." Journal of Process Control 17, no. 9 (October 2007): 728–41. http://dx.doi.org/10.1016/j.jprocont.2007.02.005.

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Barad, Miryam, and Daniel Braha. "Control Limits for Multi-stage Manufacturing Processes with Binomial Yield (Single and Multiple Production Runs)." Journal of the Operational Research Society 47, no. 1 (January 1996): 98–112. http://dx.doi.org/10.1057/jors.1996.9.

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Khabirov, F. A., T. I. Khaybullin, E. V. Granatov, and S. R. Shakirzianova. "Effect of cerebrolysin on remyelination processes in multiple sclerosis patients in stage of relapse regression." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 116, no. 12 (2016): 48. http://dx.doi.org/10.17116/jnevro201611612148-53.

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Mukherjee, Indrajit, and Pradip Kumar Ray. "Optimal process design of two-stage multiple responses grinding processes using desirability functions and metaheuristic technique." Applied Soft Computing 8, no. 1 (January 2008): 402–21. http://dx.doi.org/10.1016/j.asoc.2007.02.005.

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Kapur, Narinder, John Millar, Chris Colbourn, Pat Abbott, Philip Kennedy, and Tom Docherty. "Very Long-Term Amnesia in Association with Temporal Lobe Epilepsy: Evidence for Multiple-Stage Consolidation Processes." Brain and Cognition 35, no. 1 (October 1997): 58–70. http://dx.doi.org/10.1006/brcg.1997.0927.

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Anand, Mohit, and Philippe Monin. "Innovation Processes in Emerging Markets: Empirical Evidence from the Indian Insurance Industry." Management international 18, no. 1 (January 31, 2014): 40–57. http://dx.doi.org/10.7202/1022219ar.

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How do organizations innovate to respond to emerging market issues? Building on a multiple-case research design, we study four cases of innovation in the Indian insurance industry. In the first stage of our analysis, we identify seven innovation processes: Demystification, technologization, bundlization, indigenization, retailization, commoditization and segmentation. In the second stage, we find that these seven processes serve as generic responses to three typical issues: management of meanings and values, accessibility and affordability that firms face in emerging markets. Our findings cont

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12

Gironi, M., C. Solaro, C. Meazza, M. Vaghi, L. Montagna, M. Rovaris, A. P. Batocchi, et al. "Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis." Multiple Sclerosis International 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/836486.

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Evidence suggests that neurohormones such as GH and IGF-I are involved in the neuroreparative processes in multiple sclerosis (MS). GH and IGF-I blood levels in naïve MS patients with different disease courses were investigated in this study. Serum GH and IGF-I in untreated MS patients (n=64), healthy controls (HC,n=62), and patients affected by other neurological diseases (OND,n=46) were evaluated with a solid-phase-enzyme-labeled-chemiluminescent-immunometric assay. No differences were detected in GH across MS, OND, and HC (MS=0.87±1.32 ng/mL;OND=1.66±3.7; andHC=1.69±3.35;P=0.858) when consi

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13

Mousavi Anijdan, S. H., D. Kang, N. Singh, and M. Gallerneault. "Precipitation behavior of strip cast Al–Mg–0.4Sc–0.15Zr alloy under single and multiple-stage aging processes." Materials Science and Engineering: A 640 (July 2015): 275–79. http://dx.doi.org/10.1016/j.msea.2015.06.006.

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14

Paty, D. W. "Multiple Sclerosis: Assessment of Disease Progression and Effects of Treatment." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (August 1987): 518–20. http://dx.doi.org/10.1017/s0317167100038038.

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ABSTRACT:MS could well be a two stage disease. The first stage involves the sequential development of multiple small lesions, mostly inflammatory, that accumulate at a given rate. The second stage could be that of consolidation and confluence of lesions that involves not only demyelination but gliosis. MRI now gives us an opportunity to watch the evolution of these processes and also to monitor treatment effects. It is only after the evolution of this process is understood that we can design rational therapies directed toward the prevention of spasticity in MS.

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15

PATSADU, Orasa, Pongsakorn TANGCHITWILAIKUN, and Supanut LOWSUWANKUL. "Liver Cancer Patient Classification on a Multiple-Stage using Hybrid Classification Methods." Walailak Journal of Science and Technology (WJST) 18, no. 9 (April 20, 2021): Manuscript. http://dx.doi.org/10.48048/wjst.2021.9169.

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This paper proposes a model to detect liver cancer patients and estimate the abnormality level of livers using a classification method based on an Indian liver patient dataset. The dataset is prepared by 3 processes: preliminary study, data cleansing, and handling imbalanced class to build the model based on multiple-stages using hybrid classification methods. The 1st stage is liver cancer patient detection. The 2nd stage is abnormality level of liver estimation, as divided using the DeRitis Ratio. The abnormality level of livers is divided into 3 levels: low, medium, and high, called ALL fram

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16

Johnston, James C., Robert S. McCann, and Roger W. Remington. "Chronometric Evidence for two Types of Attention." Psychological Science 6, no. 6 (November 1995): 365–69. http://dx.doi.org/10.1111/j.1467-9280.1995.tb00527.x.

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Parallel processing in the human brain is subject to severe attentional limits, but it is unclear whether such limits arise from a single attentional process or multiple distinct attentional processes We provide new evidence that two candidates, input attention and central attention, operate at different temporal stages of processing This conclusion is supported by chronometric analyses showing that the same reference stage (letter identification) operates after the stage at which input attention operates, but prior to the stage at which central attention operates The finding that attention op

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17

Liu, D. Y., Ping Yu Jiang, and L. Guo. "Study on Machining Error Propagation for Multistage Processes." Applied Mechanics and Materials 10-12 (December 2007): 379–84. http://dx.doi.org/10.4028/www.scientific.net/amm.10-12.379.

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Digital action mechanism of machining error propagation has been a hot research topic in recent years. A complicated machining system usually contains multiple stages. Basing on analyzing digital behaviors of machining process flow, a methodology of machining error monitoring and control is put forward, which is based on dynamic programming. Under this framework, state of machining feature is described with vector matrices, and then differential transition matrices are used to represent the influences of error sources on machining feature quality of workpiece. Basing on this, a general error p

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18

Li, Yan, Laura M. Lee, and Jason Rock. "Modeling population dynamics and nonstationary processes of difficult-to-age fishery species with a hierarchical Bayesian two-stage model." Canadian Journal of Fisheries and Aquatic Sciences 76, no. 12 (December 2019): 2199–214. http://dx.doi.org/10.1139/cjfas-2018-0298.

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Modeling population dynamics and establishing a comprehensive population assessment for fishery species that are difficult to age have been challenging. Determination of age for such species is still an unresolved issue or is at best uncertain. Catch-survey analysis does not require full age information but can still provide a comprehensive population assessment. It was extended to incorporate multiple surveys and multiple sources of uncertainties within the statistical catch-at-age framework in the applications to crustaceans. Here, we further generalize and extend the multiple survey catch-s

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19

Zemskov, Andrei M., Tatiyana A. Berezhnova, Veronika A. Zemskova, Kseniya S. Dyadina, Yana V. Kulintsova, and Anton V. Larin. "Immune-metabolic genesis of pathological processes." Research Results in Pharmacology 5, no. 4 (December 12, 2019): 19–31. http://dx.doi.org/10.3897/rrpharmacology.5.38386.

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This article deals with metabolic-immune processes at rest and under stress conditions, which, in turn, results in the development of immune-dependent and immune-associated disorders. The article analyzes study results and conclusions of various literature sources and experimental data in healthy individuals and patients suffering from non-specific inflammatory lung diseases; purulent-inflammatory diseases and their combinations, primary and secondary progressive multiple sclerosis in the acute stage and remission. Research studies investigated the impact of the type, stage, combination of dis

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20

Chandran, Siddharthan, David Hunt, Alexis Joannides, Chao Zhao, Alastair Compston, and Robin J. M. Franklin. "Myelin repair: the role of stem and precursor cells in multiple sclerosis." Philosophical Transactions of the Royal Society B: Biological Sciences 363, no. 1489 (February 5, 2007): 171–83. http://dx.doi.org/10.1098/rstb.2006.2019.

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Multiple sclerosis is the most common potential cause of neurological disability in young adults. The disease has two distinct clinical phases, each reflecting a dominant role for separate pathological processes: inflammation drives activity during the relapsing–remitting stage and axon degeneration represents the principal substrate of progressive disability. Recent advances in disease-modifying treatments target only the inflammatory process. They are ineffective in the progressive stage, leaving the science of disease progression unsolved. Here, the requirement is for strategies that promot

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21

Paltayian, George, Katerina D. Gotzamani, Andreas C. Georgiou, and Andreas Andronikidis. "Aligning customer requirements and organizational constraints to service processes and strategies." Business Process Management Journal 23, no. 5 (September 4, 2017): 1018–42. http://dx.doi.org/10.1108/bpmj-10-2015-0140.

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Purpose Recognizing the fundamental role of quality as a means to differentiate service organizations, the purpose of this paper is to propose a strategic decision making framework for service organizations, which prioritizes performance improvement strategies that are rooted to customer requirements, organizational goals and constrained by organizational resources. Design/methodology/approach The proposed framework is realized through the implementation of two stages and four distinct phases mirroring the combination of enhanced quality function deployment (first stage), and zero-one goal pro

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22

Leithold, Nick, Heiko Haase, and Arndt Lautenschläger. "Stage-Gate® for SMEs: a qualitative study in Germany." European Journal of Innovation Management 18, no. 2 (May 11, 2015): 130–49. http://dx.doi.org/10.1108/ejim-07-2014-0070.

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Purpose – The purpose of this paper is to analyse the structure of the new product development (NPD) processes of small- and medium-sized enterprises (SMEs) and researches the transferability of the Stage-Gate® system for SMEs. Design/methodology/approach – The authors used a qualitative multiple case study design. Data were gathered from 49 semi-structured, face-to-face interviews with German firms. The authors used blank cards and a bar graph to measure process structures. The NPD processes were assessed using both objective and subjective success criteria. Pattern matching was used as a sys

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23

Lipski, Jerzy, and Kazimierz Zaleski. "Implementation of artificial intelligence in optimisation of technological processes." MATEC Web of Conferences 252 (2019): 03008. http://dx.doi.org/10.1051/matecconf/201925203008.

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This article introduces an algorithm for determining optimal parameters of a technological process. The objective function is the processing time of operations (efficiency) at the constraint of quality requirements of finish according to the designer specification. The problem of selecting a correct combination of processing parameters may only be solved when the cause-and-effect relationship between the finish quality and the machining settings is known. If the process considered for optimisation is repeatable, it appears economically viable to invest resources in the development of a model t

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Imaizumi, Mitsuhiro, and Mitsutaka Kimura. "Reliability Analysis of a System with Multiple-Stage Policy Considering Type I and II Errors." International Journal of Reliability, Quality and Safety Engineering 26, no. 06 (December 2019): 1950028. http://dx.doi.org/10.1142/s0218539319500281.

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This paper formulates a stochastic model for a system with illegal access. The server has the function of IDS, and illegal access is checked in multiple stages which consist of simple check and detailed check. In this model, we consider type I and II errors of simple check and a type I error of detailed check. There are two cases where IDS judges the occurrence of illegal access erroneously. One is when illegal access does not occur, and the other is when illegal access occurs. We apply the theory of Markov renewal processes to a system with illegal access, and derive the mean time and the exp

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25

Desebrock, Clea, and Charles Spence. "The Self-Prioritization Effect: Self-referential processing in movement highlights modulation at multiple stages." Attention, Perception, & Psychophysics 83, no. 6 (April 16, 2021): 2656–74. http://dx.doi.org/10.3758/s13414-021-02295-0.

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AbstractA wealth of recent research supports the validity of the Self-Prioritization Effect (SPE)—the performance advantage for responses to self-associated as compared with other-person-associated stimuli in a shape–label matching task. However, inconsistent findings have been reported regarding the particular stage(s) of information processing that are influenced. In one account, self-prioritization modulates multiple stages of processing, whereas according to a competing account, self-prioritization is driven solely by a modulation in central-stage information-processing. To decide between

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Dymova, Ludmila, Krzysztof Kaczmarek, and Pavel Sevastjanov. "Multiple-Criteria Fuzzy Optimization of the Heat Treatment Processes for Two Steel Rolled Products." Applied Sciences 11, no. 5 (March 5, 2021): 2324. http://dx.doi.org/10.3390/app11052324.

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This paper presents a developed method for fuzzy multiple-criteria optimization of the rolled-steel heat treatment processes in the modern metallurgical plant. At the first stage of the study, by means of passive industrial experiments or a mathematical simulation of heat transfer processes, and using statistical methods, the regression dependencies of the output parameters of process quality on the input variables that are technological parameters are established. Then, based on the quality parameters, membership functions are formed that represent local criteria of the process quality, and t

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Xie, Nan, Martin Wiederhold, Bei Rong Zheng, Wei Xue, and Peter Dittrich. "Optimizing Maintenance Strategy of Multi-Stage Production System Based on Genetic Algorithm and Configuration." Applied Mechanics and Materials 365-366 (August 2013): 576–79. http://dx.doi.org/10.4028/www.scientific.net/amm.365-366.576.

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The optimized maintenance strategy of multi-stage production line is influenced by device processing ways, parts process plan and equipment deterioration process and other factors. Moreover, the production processes of parts exist constraint relationship. Based machining process plan of complex parts, the order relations of its operation processes is analyzed; the optimized multi-stage production line maintenance model is constructed with multiple objectives including production time, maintenance time, production cost and maintenance cost; the genetic algorithm is used to solve the model, and

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Dellero, Younes, Vanessa Clouet, Nathalie Marnet, Anthoni Pellizzaro, Sylvain Dechaumet, Marie-Françoise Niogret, and Alain Bouchereau. "Leaf status and environmental signals jointly regulate proline metabolism in winter oilseed rape." Journal of Experimental Botany 71, no. 6 (December 6, 2019): 2098–111. http://dx.doi.org/10.1093/jxb/erz538.

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Abstract Proline metabolism is an essential component of plant adaptation to multiple environmental stress conditions that is also known to participate in specific developmental phases, particularly in reproductive organs. Recent evidence suggested a possible role for proline catabolism in Brassica napus for nitrogen remobilization processes from source leaves at the vegetative stage. Here, we investigate transcript levels of Δ1-PYRROLINE-5-CARBOXYLATE SYNTHASE (P5CS) and PROLINE DEHYDROGENASE (ProDH) genes at the vegetative stage with respect to net proline biosynthesis and degradation fluxes

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Tian, Feng, and Xiaodong Wang. "An approach for multiple-fracture horizontal gas wells under a two-stage inner boundary condition." International Journal of Heat and Mass Transfer 150 (April 2020): 119284. http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.119284.

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Kato, Takeharu, Hirokazu Sasaki, Hiroyuki Iwai, Akira Ibi, Naoji Kashima, Toshiharu Niwa, Takemi Muroga, et al. "Transmission electron microscopy studies of YBCO coated conductors prepared by pulsed-laser deposition and multiple-stage chemical vapor deposition processes." Physica C: Superconductivity and its Applications 426-431 (October 2005): 1033–42. http://dx.doi.org/10.1016/j.physc.2005.01.058.

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Widiputri, Diah Indriani, Adianto Jayaratana, and Evita Herawati Legowo. "Improving the Methodology of Squalene Extraction from Palm Fatty Acid Distillate (PFAD) through Enhanced Pre-Treatment Process." Journal of Functional Food and Nutraceutical 1, no. 2 (February 29, 2020): 101–10. http://dx.doi.org/10.33555/jffn.v1i2.28.

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Palm Fatty Acid Distillate (PFAD) resulted from refinery process of crude palm oil (CPO) contains some beneficial bioactive compounds such as squalene, which is one of the best natural emollients for pharmaceuticals and cosmetics. The need to overcome the problem with the abundant amount of PFAD as a waste has led to the attempts to extract squalene from PFAD in single and multiple stage processes. However, many impurities such as free fatty acids were still found to be present in the yielded squalene extract. Therefore, in this research an effort to optimize the pre-treatment process prior to

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Lippke, Sonia, Ralf Schwarzer, Jochen P. Ziegelmann, Urte Scholz, and Benjamin Schüz. "Testing Stage-Specific Effects of a Stage-Matched Intervention: A Randomized Controlled Trial Targeting Physical Exercise and Its Predictors." Health Education & Behavior 37, no. 4 (June 14, 2010): 533–46. http://dx.doi.org/10.1177/1090198109359386.

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Health education interventions can be tailored toward stages of change. This strategy is based on theories that predict at which stage which variables are indicative of subsequent behavior change processes. For example, planning is regarded as being effective in intenders. However, rather few studies have tested whether matched interventions are more successful for stage transitions than mismatched ones. Also very few previous studies have identified specific variables as targets of stage-matched interventions. A 2 (condition) × 2 (stages) experimental study tested the effects of stage-matched

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Li, Bin, Xiaoqiang Zhai, and Xiwen Cheng. "Thermal performance analysis and optimization of multiple stage latent heat storage unit based on entransy theory." International Journal of Heat and Mass Transfer 135 (June 2019): 149–57. http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.01.123.

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Qin, Weize, and Huajian Yao. "Characteristics of subevents and three-stage rupture processes of the 2015 Mw 7.8 Gorkha Nepal earthquake from multiple-array back projection." Journal of Asian Earth Sciences 133 (January 2017): 72–79. http://dx.doi.org/10.1016/j.jseaes.2016.11.012.

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Forgatch, Marion S., James J. Snyder, Gerald R. Patterson, Michael R. Pauldine, Yvonne Chaw, Katie Elish, Jasmine B. Harris, and Eric B. Richardson. "Resurrecting the chimera: Progressions in parenting and peer processes." Development and Psychopathology 28, no. 3 (July 18, 2016): 689–706. http://dx.doi.org/10.1017/s0954579416000250.

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AbstractThis report uses 6-year outcomes of the Oregon Divorce Study to examine the processes by which parenting practices affect deviant peer association during two developmental stages: early to middle childhood and late childhood to early adolescence. The participants were 238 newly divorced mothers and their 5- to 8-year-old sons who were randomly assigned to Parent Management Training—Oregon Model (PMTO®) or to a no-treatment control group. Parenting practices, child delinquent behavior, and deviant peer association were repeatedly assessed from baseline to 6 years after baseline using mu

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Podbielska, Maria, Joan O’Keeffe, and Anna Pokryszko-Dragan. "New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration." International Journal of Molecular Sciences 22, no. 14 (July 7, 2021): 7319. http://dx.doi.org/10.3390/ijms22147319.

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Multiple sclerosis (MS) is a central nervous system disease with complex pathogenesis, including two main processes: immune-mediated inflammatory demyelination and progressive degeneration with axonal loss. Despite recent progress in our understanding and management of MS, availability of sensitive and specific biomarkers for these both processes, as well as neuroprotective therapeutic options targeted at progressive phase of disease, are still being sought. Given their abundance in the myelin sheath, lipids are believed to play a central role in underlying immunopathogenesis in MS and seem to

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Vorobyov, Valery, Aleksey Manakov, Anatoly Reger, and Iuliia Tanaino. "Optimization of processes in railways based on the cost management model." MATEC Web of Conferences 216 (2018): 02009. http://dx.doi.org/10.1051/matecconf/201821602009.

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The main aim of activities of the branches of vertically integrated Russian Railways JSC is enhancing of manageability and efficiency of business operations. At the current stage, the issue of optimization of costs for product transportation and facilities maintenance in the system of production and technological processes of the railway network has gained relevance. The purpose of this study is development of a mathematical model for the logistic system of transportation, storage, cargo-handling operations, facilities maintenance and reconstruction. Methods of spatial and dynamic modeling in

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Filatov, Maxim, Yulia Khramova, and Maria Semenova. "Molecular Mechanisms of Prophase I Meiotic Arrest Maintenance and Meiotic Resumption in Mammalian Oocytes." Reproductive Sciences 26, no. 11 (March 27, 2018): 1519–37. http://dx.doi.org/10.1177/1933719118765974.

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Mechanisms of meiotic prophase I arrest maintenance (germinal vesicle [GV] stage) and meiotic resumption (germinal vesicle breakdown [GVBD] stage) in mammalian oocytes seem to be very complicated. These processes are regulated via multiple molecular cascades at transcriptional, translational, and posttranslational levels, and many of them are interrelated. There are many molecular cascades of meiosis maintaining and meiotic resumption in oocyte which are orchestrated by multiple molecules produced by pituitary gland and follicular cells. Furthermore, many of these molecular cascades are duplic

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Kleinman, Matthew R., Hansem Sohn, and Daeyeol Lee. "A two-stage model of concurrent interval timing in monkeys." Journal of Neurophysiology 116, no. 3 (September 1, 2016): 1068–81. http://dx.doi.org/10.1152/jn.00375.2016.

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Accurate timing is critical for a wide range of cognitive processes and behaviors. In addition, complex environments frequently necessitate the simultaneous timing of multiple intervals, and behavioral performance in concurrent timing can constrain formal models of timing behavior and provide important insights into the corresponding neural mechanisms. However, the accuracy of such concurrent timing has not been rigorously examined. We developed a novel behavioral paradigm in which rhesus monkeys were incentivized to time two independent intervals. The onset asynchrony of two overlapping inter

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Mujib, Mujib. "Penjenjangan Kemampuan Berpikir Kritis Matematis Berdasarkan Teori Bloom Ditinjau Dari Kecerdasan Multiple Intelligences." Desimal: Jurnal Matematika 2, no. 1 (January 31, 2019): 87–103. http://dx.doi.org/10.24042/djm.v2i1.3534.

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This study aims to see how the mathematical model of critical thinking skills is based on Bloom theory in terms of Multiple Intelligences intelligence, namely Students have Linguistic Intelligences, Logical-Mathematical and Spatial Intelligence Intelligence. The research method used is descriptive qualitative. Subjects taken in this study were using purpose sampling techniques. Data collection techniques used are tests, questionnaires, observation and interviews. Data analysis was carried out in a qualitative descriptive manner. Each Multiple Intelligences intelligence is capable of observing,

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Korecká, Lucie, Karel Vytřas, and Zuzana Bílková. "Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays." Current Medicinal Chemistry 25, no. 33 (October 24, 2018): 3973–87. http://dx.doi.org/10.2174/0929867324666171121101245.

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Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations. This contribution reviews recent developments in the area of electrochem

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Xu, Bin, Xu Chen, Xiuhui Huang, and Lili Tao. "A Multistrategy-Based Multiobjective Differential Evolution for Optimal Control in Chemical Processes." Complexity 2018 (September 16, 2018): 1–22. http://dx.doi.org/10.1155/2018/2317860.

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Optimal control problems with multiple conflicting objectives in chemical processes are quite challenging. To solve such problems, we put forward a multistrategy-based multiobjective differential evolution, in which (1) a hybrid selection strategy is incorporated from the motivation of no single strategy outperforming all other ones in every stage; (2) a multipopulation strategy is applied to represent the main population and current optimum, and a cyclic crowding estimation is developed to maintain these optimum; and (3) a multimutation strategy is constructed to improve both exploration and

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Yao, Baojin, Mei Zhang, Meixin Liu, Yuxin Liu, Yaozhong Hu, and Yu Zhao. "Transcriptomic characterization elucidates a signaling network that controls antler growth." Genome 61, no. 12 (December 2018): 829–41. http://dx.doi.org/10.1139/gen-2017-0241.

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Deer antlers are amazing appendages with the fastest growth rate among mammalian organs. Antler growth is driven by the growth center through a modified endochondral ossification process. Thus, identification of signaling pathways functioning in antler growth center would help us to uncover the underlying molecular mechanism of rapid antler growth. Furthermore, exploring and dissecting the molecular mechanism that regulates antler growth is extremely important and helpful for identifying methods to enhance long bone growth and treat cartilage- and bone-related diseases. In this study, we build

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Ismail, Hanafy M., Victoria Barton, Matthew Phanchana, Sitthivut Charoensutthivarakul, Michael H. L. Wong, Janet Hemingway, Giancarlo A. Biagini, Paul M. O’Neill, and Stephen A. Ward. "Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7." Proceedings of the National Academy of Sciences 113, no. 8 (February 8, 2016): 2080–85. http://dx.doi.org/10.1073/pnas.1600459113.

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The artemisinin (ART)-based antimalarials have contributed significantly to reducing global malaria deaths over the past decade, but we still do not know how they kill parasites. To gain greater insight into the potential mechanisms of ART drug action, we developed a suite of ART activity-based protein profiling probes to identify parasite protein drug targets in situ. Probes were designed to retain biological activity and alkylate the molecular target(s) of Plasmodium falciparum 3D7 parasites in situ. Proteins tagged with the ART probe can then be isolated using click chemistry before identif

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Enders, Michael, Thorsten Heider, Andreas Ludwig, and Stefanie Kuerten. "Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium." International Journal of Molecular Sciences 21, no. 5 (February 28, 2020): 1663. http://dx.doi.org/10.3390/ijms21051663.

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Calcium ions are vital for maintaining the physiological and biochemical processes inside cells. The central nervous system (CNS) is particularly dependent on calcium homeostasis and its dysregulation has been associated with several neurodegenerative disorders including Parkinson’s disease (PD), Alzheimer’s disease (AD) and Huntington’s disease (HD), as well as with multiple sclerosis (MS). Hence, the modulation of calcium influx into the cells and the targeting of calcium-mediated signaling pathways may present a promising therapeutic approach for these diseases. This review provides an over

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Cesaroni, Francesca Maria, Annalisa Sentuti, and Maria Gabriella Pediconi. "Fading and transformation: how a woman entrepreneur's multiple identities interact throughout her life." International Journal of Entrepreneurial Behavior & Research 27, no. 4 (March 30, 2021): 1033–53. http://dx.doi.org/10.1108/ijebr-04-2020-0239.

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PurposeThis paper aims to further the understanding of women entrepreneurs' multiple identities by exploring how they interact throughout women's life cycles.Design/methodology/approachThis article combines a case study and a narrative analysis to investigate the experience of a woman who founded a business and retired after passing it on to her son. Data were collected by combining two different methods: biographical interview and follow-up interviews or conversations.FindingsFindings show that interactions between a woman entrepreneur's multiple identities may evolve through two main process

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Jachimowski, Roland, Piotr Gołębiowski, Mariusz Izdebski, Dariusz Pyza, and Emilian Szczepański. "Designing and efficiency of database for simulation of processes in systems. Case study for the simulation of warehouse processes." Archives of Transport 41, no. 1 (March 13, 2017): 31–42. http://dx.doi.org/10.5604/01.3001.0009.7380.

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The basis of each IT system is data exchange both between individual modules of program and between program and user. The number of exchanged data and the number of operations on the data, which should be performed, require application of professional tools allowing for collecting and performing operations on multiple types of data. One of these tools are databases, which are an essential part of any IT system. With database designing are connected many decision problems which can occur both during the construction of database management system and at the stage of integration of entire user ap

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Gao, Junxia, Fenghe Wu, Jun Tang, and Zichun Geng. "A Method of Two-Stage Pressure Control Based on Multistage Orifices." Applied Sciences 11, no. 2 (January 8, 2021): 589. http://dx.doi.org/10.3390/app11020589.

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The interaction of pressure and flow in a hydraulic system with multiple working conditions, multiple actuators, and large flow limits action adjustment and control. Through a pilot pressure control circuit, hydraulically operated valves can adjust pressure or direction more effectively. A recent study proposed a two-stage pressure control method based on multistage orifices and solenoid valves. The requirements of the number and diameter ratio of short orifices in the series to realize the two-stage pressure control were theoretically analyzed. Scheme design and experiment were carried out. T

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Miller, David L., David Fifield, Ewan Wakefield, and Douglas B. Sigourney. "Extending density surface models to include multiple and double-observer survey data." PeerJ 9 (September 2, 2021): e12113. http://dx.doi.org/10.7717/peerj.12113.

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Spatial models of density and abundance are widely used in both ecological research (e.g., to study habitat use) and wildlife management (e.g., for population monitoring and environmental impact assessment). Increasingly, modellers are tasked with integrating data from multiple sources, collected via different observation processes. Distance sampling is an efficient and widely used survey and analysis technique. Within this framework, observation processes are modelled via detection functions. We seek to take multiple data sources and fit them in a single spatial model. Density surface models

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Alafchi, Behnaz, Hossein Mahjub, Leili Tapak, Ghodratollah Roshanaei, and Mohammad Ali Amirzargar. "Two-Stage Joint Model for Multivariate Longitudinal and Multistate Processes, with Application to Renal Transplantation Data." Journal of Probability and Statistics 2021 (April 9, 2021): 1–10. http://dx.doi.org/10.1155/2021/6641602.

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In longitudinal studies, clinicians usually collect longitudinal biomarkers’ measurements over time until an event such as recovery, disease relapse, or death occurs. Joint modeling approaches are increasingly used to study the association between one longitudinal and one survival outcome. However, in practice, a patient may experience multiple disease progression events successively. So instead of modeling of a single event, progression of the disease as a multistate process should be modeled. On the other hand, in such studies, multivariate longitudinal outcomes may be collected and their as

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