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Rozprawy doktorskie na temat „Multiplex screening”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Kownarumit, Supaporn. "Multiplex screening using enzyme inhibition, fluorescence detection and chemometrics." Thesis, Loughborough University, 2006. https://dspace.lboro.ac.uk/2134/12308.

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Fluorescence enzyme inhibition assays have been established for a number of years as valuable methods of analysis in clinical chemistry and other fields. Those in common use are normally single analyte assays. However, in many cases (e.g. drug screening) dual or multiplex assays would be much more valuable, with the advantages of increased information content, saving in time and costs, and the elimination of some sources of sampling variance. This project has investigated single and dual screening assays of enzyme inhibitors, namely 3-nitrophenylboronic acid (3-NPBA), phenylethyl /3-0- thiogal

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Dobosz, Paulina Dorota. "Screening methodologies for the determination of water contaminant residues by compact disk technology." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/79548.

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[EN] The contamination of water resources with many industrial, agricultural and other chemicals is one of the key environmental problems that humanity is facing nowadays. Despite the fact that they are usually present at very low concentration, they possess a significant risk to aquatic and human life. To address this issue many national and international institutions set different regulations to monitor and control the water quality. Currently, the monitoring of compounds included in official watch lists is conducted by chromatographic and mass spectroscopic methods. These techniques are

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3

Claesson, Cim. "Is Multiplex Ligation-dependent Probe Amplification a good method for screening formalin fixed paraffin embedded neuroblastoma tumors?" Thesis, Högskolan i Skövde, Institutionen för vård och natur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5442.

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Neuroblastoma is one of the most enigmatic solid tumors for scientists and pediatric oncologists. Neuroblastoma is primary a childhood form of cancer, consisting of neuroectodermal cells that originate from the neural crest and is destined for the adrenal medulla and sympathetic nervous system. The Neuroblastoma group at The University of Gothenburg received formalin-fixed paraffin-embedded tumor samples from Vietnam and this project was to examine if the quality of the DNA from, is good enough to run comparative genome hybridization array experiment on by using a cheaper technique Multiple

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Rudalska, Ramona [Verfasser], and Christiane [Akademischer Betreuer] Ritter. "Multiplex in vitro and in vivo RNAi screening to identify treatment response modifiers of targeted therapies in HCC / Ramona Rudalska ; Betreuer: Christiane Ritter." Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/1175820806/34.

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Pires, Joyce Suellen Coêlho. "Desenvolvimento de produto multiparamétrico para triagem pré-natal de anticorpos IgG contra doenças infecciosas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46137/tde-31102016-085414/.

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Infecção congênita é aquela transmitida da mãe ao feto antes do nascimento. A transmissão vertical pode ocorrer por via transplacentária ou por contato direto com o patógeno durante o parto. A fonte de infecção é o microrganismo presente no sangue da gestante durante a infecção primária ou crônica. Estima-se que as infecções perinatais representam 2% a 3% de todas anomalias congênitas e as mais comuns são representadas pela sigla TORCH, que inclui Toxoplasmose, Outras (como sífilis e varicela-zoster), Rubeóla, Citomegalovírus e Herpes. A maioria das infecções TORCH causa morbidade materna leve

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6

Gunnar, Erika. "Characterization of the genetic basis in two cases of abetalipoproteinemia reveals two novel mutations." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-58620.

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<p>BACKGROUND: Abetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by mutations in the gene coding for microsomal triglyceride transfer protein (MTTP).</p><p>AIM: To characterize the genetic basis of ABL in two unrelated patients.</p><p>RESULTS: In the first patient, the substitution c.1911C>T in exon 12 of the <em>MTTP</em> gene, resulting in the protein substitution p.P552L, was discovered using mutation screening. The parents are heterozygous and the proband is a homozygous carrier of this substitution. Using restriction fragment length polymorphism (RFLP), 100 control

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7

Theriault, Mylene A. "Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30318.

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The development of new high throughput technologies able to multiplex disease biomarkers as well as advances in medical treatments has lead to the recent expansion of the newborn screening panel to include DNA-based targets. Four rare disorders; deletion 22q11.2 syndrome and Spinal Muscular Atrophy (SMA), Severe Combined Immunodeficiency (SCID) and Congenital Cytomegalovirus (CMV), are potential candidates for inclusion to the newborn screening panel within the next few years. The major focus of this study was to determine whether 5’-hydrolysis assays developed for the four distinct disorders

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8

Seward, Lori Welte. "A multiple stress, multiple component stress screening cost model." Thesis, Virginia Tech, 1985. http://hdl.handle.net/10919/41578.

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<p>Environmental stress screening is used to enhance reliability by decreasing the number of failures experienced during customer use. It is suggested that added benefit can be gained by applying multiple stresses rather than a single stress, as is done presently. A further modification is to apply the stress at the assembly level, accelerating different types of components at the same time. Different component E A e acceleration effects must then be considered.</p> <p> The problem these modifications present is how to choose the appropriate stress levels and the time duration of the stress sc

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9

Meuli, Christian. "Reverse assays for high-thorughput multiplexd screening." Thesis, KTH, Skolan för bioteknologi (BIO), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-149452.

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10

Macnee, C., and Jean Croce Hemphill. "Screening Clinics for the Homeless: Achieving Multiple Outcomes." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etsu-works/7590.

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Tyler-Merrick, Gaye Margaret. "Screening for Antisocial Development." Thesis, University of Canterbury. School of Health Sciences, 2014. http://hdl.handle.net/10092/10263.

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Teachers report that there are an increased number of students engaging in persistent antisocial behaviour in their classrooms. Teachers need to identify these students early because if there is early identification then there is the potential for early intervention, which in turn may prevent negative long-term outcomes for these students as well as long-term costs to society. The aims of this study were (1) develop a psychometrically sound, cost effective, three-step multiple gating behaviour screening procedure that teachers could use in their kindergarten/classroom so that they could iden

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12

Burton, Richard Matthew. "Screening for cognitive impairments in people with multiple sclerosis." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/27616.

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Multiple Sclerosis is the most commonly found neurological condition among young adults and in early adulthood. Symptoms exhibit ‘disease heterogeneity’ and vary from sufferer to sufferer. Cognitive impairments in the domains of processing speed, memory, attention, visuospatial perception and executive function are commonly found. Literature Review: A systematic review of the literature on screening for cognitive impairments is presented. The paper considers the key measures of validity and reliability for the screening tests reviewed and uses a standard appraisal tool to assess the methodolog

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Jenkins, Bradlee A., and L. Lee Glenn. "Cystic Fibrosis Carrier Screening Attitudes and Multiple Hypothesis Testing." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/7466.

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The recent study by Cunningham, Lewis, Curnow, Glazner, and Massie [1] on the attitudes of respiratory physicians and clinic coordinators towards cystic fibrosis (CF) carrier screening drew several unsupported conclusions because the α level of 0.05 was not corrected for the large number of hypothesis tests conducted, leading to a Type 2 error and the acceptance of hypotheses that were likely false [2].

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14

Boskov, Lazar. "One-sided screening procedure using multiple normally distributed variables." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06302009-040451/.

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Sebire, Neil James. "Prenatal diagnosis and management of multiple pregnancies : the role of the 10-14 week ultrasound examination." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391612.

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16

Beste, Christian, Moritz Mückschel, Madlen Paucke, and Tjalf Ziemssen. "Dual-Tasking in Multiple Sclerosis – Implications for a Cognitive Screening Instrument." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-233900.

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The monitoring of cognitive functions is central to the assessment and consecutive management of multiple sclerosis (MS). Though, especially cognitive processes that are central to everyday behavior like dual-tasking are often neglected. We examined dual-task performance using a psychological-refractory period (PRP) task in N = 21 patients and healthy controls and conducted standard neuropsychological tests. In dual-tasking, MS patients committed more erroneous responses when dual-tasking was difficult. In easier conditions, performance of MS patients did not differ to controls. Interestingly,

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17

Chang, Chien Kuang Che. "Automated lung screening system of multiple pathological targets in multislice CT." Thesis, Evry, Institut national des télécommunications, 2011. http://www.theses.fr/2011TELE0021/document.

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Cette recherche vise à développer un système de diagnostic assisté par ordinateur pour la détection automatique et la classification des pathologies du parenchyme pulmonaire telles que les pneumonies interstitielles idiopathiques et l'emphysème, en tomodensitométrie multicoupe. L’approche proposée repose sur morphologie mathématique 3-D, analyse de texture et logique floue, et peut être divisée en quatre étapes : (1) un schéma de décomposition multi-résolution basé sur un filtre 3-D morphologique exploitée pour discriminer les régions pulmonaires selon différentes échelles d’analyse. (2) Un pa

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Chang, Chien Kuang Che. "Automated lung screening system of multiple pathological targets in multislice CT." Electronic Thesis or Diss., Evry, Institut national des télécommunications, 2011. http://www.theses.fr/2011TELE0021.

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Cette recherche vise à développer un système de diagnostic assisté par ordinateur pour la détection automatique et la classification des pathologies du parenchyme pulmonaire telles que les pneumonies interstitielles idiopathiques et l'emphysème, en tomodensitométrie multicoupe. L’approche proposée repose sur morphologie mathématique 3-D, analyse de texture et logique floue, et peut être divisée en quatre étapes : (1) un schéma de décomposition multi-résolution basé sur un filtre 3-D morphologique exploitée pour discriminer les régions pulmonaires selon différentes échelles d’analyse. (2) Un pa

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19

Green, Melanie Leslie Dawn. "The identification of novel autoantigens by means of serological screening of a cDNA expression library constructed from multiple sclerosis brain tissues." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0018/MQ54892.pdf.

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Chen, Ye. "Multiple Criteria Decision Analysis: Classification Problems and Solutions." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2892.

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Multiple criteria decision analysis (MCDA) techniques are developed to address challenging classification problems arising in engineering management and elsewhere. MCDA consists of a set of principles and tools to assist a decision maker (DM) to solve a decision problem with a finite set of alternatives compared according to two or more criteria, which are usually conflicting. The three types of classification problems to which original research contributions are made are <ol> <li>Screening: Reduce a large set of alternatives to a smaller set that most likely contains the best choice.

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Jacob, Pierre. "Unraveling new components of abiotic stress signaling pathways through screening of a biosensor mutant population." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLE042.

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Les stress ont un impact majeur sur l'agriculture. Les études réalisées jusqu'à présent portent majoritairement sur des stress simples, appliqués indépendamment dans des conditions de culture idéales. Cependant, les combinaisons de stress sont la norme dans les champs et la réponse aux combinaisons de stress ne peut être extrapolée à partir de l'addition des réponses aux stress simples. Une analyse bioinformatique de banques de données de transcriptomique a permis d’identifier un gène (HSFA2) répondant a de multiple stress, isolés ou combinés. La présente thèse a pour but de découvrir les méca

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22

Gutter, Pamela Beth. "An evaluation of a multiple gating program screening for developmental problems in a preschool population /." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1067900442.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xi, 86 p.; also includes graphics. Includes abstract and vita. Advisor: Antoinette Miranda, College of Education. Includes bibliographical references (p. 82-86).

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Kapo, Katherine E. "Eco-Epidemiological Analysis for Screening-Level Ecological Risk Assessment: A Geographic Information Systems Approach." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1246903901.

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Niu, Yue S., Ning Hao, and Heping Zhang. "Multiple Change-Point Detection: A Selective Overview." INST MATHEMATICAL STATISTICS, 2016. http://hdl.handle.net/10150/622820.

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Very long and noisy sequence data arise from biological sciences to social science including high throughput data in genomics and stock prices in econometrics. Often such data are collected in order to identify and understand shifts in trends, for example, from a bull market to a bear market in finance or from a normal number of chromosome copies to an excessive number of chromosome copies in genetics. Thus, identifying multiple change points in a long, possibly very long, sequence is an important problem. In this article, we review both classical and new multiple change-point detection strate

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Nögel, Lukas [Verfasser], and Christoph [Akademischer Betreuer] Merten. "Multiplexed combinatorial drug screening using droplet-based microfluidics / Lukas Nögel ; Betreuer: Christoph Merten." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/120395851X/34.

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Hou, Ruizhe. "Optimal Latin Hypercube Designs for Computer Experiments Based on Multiple Objectives." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7169.

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Latin hypercube designs (LHDs) have broad applications in constructing computer experiments and sampling for Monte-Carlo integration due to its nice property of having projections evenly distributed on the univariate distribution of each input variable. The LHDs have been combined with some commonly used computer experimental design criteria to achieve enhanced design performance. For example, the Maximin-LHDs were developed to improve its space-filling property in the full dimension of all input variables. The MaxPro-LHDs were proposed in recent years to obtain nicer projections in any subspa

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Wurz, Carl. "An investigation into the utility of the ImPACT neurocognitive screening tool with patients diagnosed with multiple sclerosis." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/5366.

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Objective: The objective of this study was to investigate the utility of the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT) assessment tool in the neurocognitive screening of patients with Multiple Sclerosis (MS). Participants and Method: Patients diagnosed with Multiple Sclerosis (n = 29) were compared with a healthy control group (n = 20) of equivalent age, years of education, quality of education and estimated premorbid IQ. Measures included five ImPACT composite scores, the ImPACT Design Memory Delayed Recall subtest, the Symbol Digit Modalities Test (SDMT) that has sh

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Häberlein, Felix [Verfasser]. "A humanized zebrafish screening platform to identify GPR17 inhibitors for the treatment of multiple sclerosis / Felix Häberlein." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1228978972/34.

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DYER, PATRICK M. "PSYCHOMETRIC EVALUATION OF THE SUBSTANCE ABUSE SUBTLE SCREENING INVENTORY-2 (SASSI-2) AMONG MALE MULTIPLE SUBSTANCE ABUSERS AND THEIR FEMALE PARTNERS." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1019507283.

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Žák, Jaromír. "Vícekanálové zařízení pro elektrochemické měření ze senzorového pole." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218673.

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The work deals with n-channel system enabling many sample analysis at sort time from sensor array using electrochemical methods. The 8x12 sensor arrays are formed from 3 electrodes system created on PCB which can be used for heavy metal analysis and toxic substances determination. The control unit switches each 3 electrode sensor to 8 channel precise potentiostat which was designed for electrochemical analysis with current sensitivity below 10 pA. The potentiostat can synchronize with control unit. Developed system is able to measure up to eight single inputs and may be simply converted to mea

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31

ISERNIA, SARA. "TEORIA DELLA MENTE E SCLEROSI MULTIPLA: DA UNO SCREENING DI TEORIA DELLA MENTE A UN MODELLO DEI MECCANISMI CEREBRALI." Doctoral thesis, Università Cattolica del Sacro Cuore, 2020. http://hdl.handle.net/10280/70989.

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Il presente lavoro di tesi si propone di indagare il deficit di Teoria della Mente (ToM) nella sclerosi multipla (SM). Tale tematica è stata affrontata su due fronti: (1) indagando i meccanismi sottostanti a tale deficit attraverso due studi sperimentali, il primo comportamentale e il secondo di neuroimaging (2) e creando uno strumento di assessment ecologico per la popolazione target. I risultati dimostrano un deficit di mentalizzazione nella SM perlopiù legato alla componente cognitiva della ToM, con una maggiore compromissione nel fenotipo progressivo rispetto al remittente, e una relazio

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Ukuhor, Hyacinth Onomegwonor. "The influence of service organisation and delivery on participation in prenatal screening for Down's syndrome : a multiple case study." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5884/.

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INTRODUCTION: The way in which NHS screening programmes are organised and delivered may influence public engagement. This is of particular interest in Down’s syndrome screening where variations in uptake have not been explained by individual social characteristics. This has led to suggestion that the influence of service organisation and delivery may help to explain the variation. AIM: To explore the influence of service organisation and delivery on women and partners’ participation in screening in two different health districts in England with contrasting uptake rates. METHOD: A multiple case

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Oliver, Charlotte. "Phylogeny, histological observation, and in vitro fungicide screening and field trials of multiple Colletotrichum species, the causal agents of grape ripe rot." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/99418.

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Colletotrichum acutatum and C. gloeosporioides are fungal plant pathogens that have a global distribution, extensive host range, and convoluted taxonomy. Both species can cause grape ripe rot and are considered endemic to Virginia US. In 2012, C. acutatum and C. gloeosporioides were reclassified into species complexes that consist of 31 and 22 accepted species, respectively. The objectives of this study were to: 1) survey Virginia vineyards for grape ripe rot, and morphologically and phylogenetically identify isolates to the species within the complexes, 2) conduct an in vitro fungicide assay

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Vargas, Sanchez Jeinny. "In vivo peptide biomarker screening for molecular imaging in eae neuroinflammation." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22102/document.

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Dans les maladies neurodégénératives comme la sclérose en plaques, la neuro-inflammation modifie l'activité de la barrière hémato-encéphalique (BHE) par des altérations cellulaires et moléculaires complexes. La caractérisation de tels changements moléculaires par une approche d'étiquetage in vivo justifie la recherche d’outils de ciblage fiables et de biomarqueurs. Les stratégies pour définir in vivo ces marqueurs sont cependant compliquées par la pléthore de molécules cibles accessibles, par l’intrication des régions atteintes au sein du tissu sain et par les altérations structurales potentie

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Bodle, Christopher Ralph. "Identification of small molecule inhibitors of regulator of G protein signaling proteins for pretherapeutic development for treatment of multiple pathologies." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5420.

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Regulator of G-protein Signaling (RGS) proteins temporally regulate the G protein signaling cascades initiated by GPCR activation. Reports have established dysregulation of RGS expression in a variety of disease states including several cancers. Additionally, use of genetic ablation techniques has implicated RGS proteins in a variety of other disease states through the native action of the RGS i.e. not a consequence of dysregulation of RGS expression. Therefore identification and optimization of small molecule lead compounds that alter RGS protein function has emerged as a promising therapeuti

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Brandão, Sofia Reis. "Characterization of mitochondrial dynamics in multiple acyl-CoA dehydrogenase deficiency." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22669.

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Mestrado em Bioquímica - Bioquímica Clínica<br>As doenças da β-oxidação mitocondrial dos ácidos gordos fazem parte do painel de doenças detetadas no rastreio neonatal na grande maioria dos países desenvolvidos, incluindo Portugal. A deficiência múltipla das acil-CoA desidrogenases é uma das doenças rastreadas, sendo rara e apresentando um padrão de transmissão autossómico recessivo. Esta disfunção no metabolismo dos ácidos gordos é caracterizada por fenótipos bastante distintos, sendo reconhecidas duas formas clínicas: moderada e grave. Estudos anteriores do nosso grupo de investigação revelar

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Nobili, Alberto [Verfasser]. "Improving biocatalysts via semi-rational protein design : use of a multiple sequence alignment platform to reduce screening efforts and facilitate hit identification / Alberto Nobili." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1113294191/34.

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Gabier, Hawwa. "Development of microsatellite (SSR) marker multiplexes for future construction of a genetic linkage map for pear (Pyrus communis L.)." Thesis, University of the Western Cape, 2012. http://hdl.handle.net/11394/4013.

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>Magister Scientiae - MSc<br>Recent advances in the field of plant genetics and application of molecular technologies has lead to greater understanding of various crop genomes and their organization.The applications of these techniques include molecular markers which have been used to examine DNA variation within crop species. This allows for the creation of further genetic variation for new and favourable traits.Molecular markers or DNA markers are short fragments of DNA that can be used to locate desirable genetic traits in the genome or show specific genetic differences. The Maloideae sub

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Eklund, Birgitta I. "Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7102.

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Hubler, Zita. "Enhancing Oligodendrocyte Formation via Inhibition of the Cholesterol Biosynthesis Pathway." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595612178572819.

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Fahrenholz, Anney Renee. "Multiple-Respondent Anecdotal Assessments for Behavior Disorders: An Analysis of Interrater Agreement and Correspondence With Functional Analysis Outcomes." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4616/.

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An analysis of interrater agreement across multiple respondents on anecdotal assessments and correspondence between functional analysis outcomes was completed. Experiment I evaluated overall agreement among multiple respondents (direct-care staff) on the hypothesized function of each residents (28 adults with mental retardation) problematic behavior using the Motivational Assessment Scale (MAS) and the Functional Analysis Screening Tool (FAST). Results of the questionnaires indicated that respondents agreed on the function of the problematic behavior for 10 of the 28 residents. Experiment II e

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Jönsson, Videsäter Kerstin. "Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-889-0/.

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Frommholz, Katja [Verfasser], Thomas [Gutachter] Müller, and Kerstin [Gutachter] Hellwig. "Screening viraler Infektionen während chronischer Immunmodulation oder –suppression bei Patienten mit Multipler Sklerose und bei Patienten mit einer akuten oder chronischen Trigeminusneuralgie / Katja Frommholz ; Gutachter: Thomas Müller, Kerstin Hellwig." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1125106190/34.

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Frommholz, Katja Verfasser], Thomas [Gutachter] [Müller, and Kerstin [Gutachter] Hellwig. "Screening viraler Infektionen während chronischer Immunmodulation oder –suppression bei Patienten mit Multipler Sklerose und bei Patienten mit einer akuten oder chronischen Trigeminusneuralgie / Katja Frommholz ; Gutachter: Thomas Müller, Kerstin Hellwig." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1125106190/34.

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Bergmann, Heinrich Johannes [Verfasser], Christian [Akademischer Betreuer] Förch, Yavor [Akademischer Betreuer] Yalachkov, Christian [Gutachter] Förch, and Jochen [Gutachter] Kaiser. "Multisensorische Integration und visuelle Suchaufgaben als Screening-Verfahren für kognitive Beeinträchtigungen bei Patienten mit Multipler Sklerose : ein Pilotprojekt / Heinrich Johannes Bergmann ; Gutachter: Christian Förch, Jochen Kaiser ; Christian Förch, Yavor Yalachkov." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1234680866/34.

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Rowland, Janice. "The impact of a single brief intervention versus multiple contact lifestyle intervention on change in body weight and modifiable cardiovascular risk factors in adults who have undertaken cardiovascular risk screening." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/ef8c63c9-630b-4eb4-baa9-9bf2b40541f7.

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Obesity is an increasing cause of poor health in Scotland and contributes to many premature deaths. There are a range of preventable conditions for which causal links with obesity have been suggested including; type 2 diabetes, hypertension, hyperlipideamia (which is a major risk factor for ischemic heart disease), cardiovascular diseases (CVD) and certain cancers. CVD relates strongly to lifestyles, and risk factor modifications have been shown to reduce mortality and morbidity. It has become clear that the major contributors to poor cardiovascular health are related to adverse health behavio

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Nordahl, Åke. "Metoder för informationsoptimering vid organisk syntes." Doctoral thesis, Umeå universitet, Kemiska institutionen, 1990. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102557.

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Modén, Olof. "Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity." Doctoral thesis, Uppsala universitet, Biokemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167332.

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Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. By screening a DNA shuffling library, five recombined segments were identified that were conserved among the most active mutants. Mutational analysis confirmed the importance of these short segments as their insertion into low-active GSTs introduced higher azathioprine activity. Besides, H-site mutagenesis led to decreased azathioprine activity when the targeted po

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Lu, I.-Jen, and 盧奕蓁. "Establishment of a genetically modified crops screening system based on universal multiplex-PCR." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/21750554524561327599.

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碩士<br>國立臺灣大學<br>微生物與生化學研究所<br>97<br>The PCR targets of this multiplex PCR detection system include six transgenic elements: cauliflower mosaic virus (CaMV) 35S promoter, Agrobacterium tumefaciens nopaline synthase (nos) promoter, Agrobacterium tumefaciens nopaline synthase (nos) terminator, neomycin phosphotransferase II (npt2) gene, 5-enolpyruvylshikimate-3-phosphate synthase (CP4 epsps) gene and phosphinothricin N-acetyltransferase (pat) gene. It can screen out most of the commercialized GM events. To calculate the classifying efficiency, we use the statistical software (SPSS ver. 12.0) to s

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Ma, Siying. "Multiplex Gene Synthesis and Error Correction from Microchips Oligonucleotides and High-throughput Gene Screening with Programmable Double Emulsion Microfluidics Droplets." Diss., 2015. http://hdl.handle.net/10161/9801.

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<p>Promising applications in the design of various biological systems hold critical implications as heralded in the rising field of synthetic biology. But, to achieve these goals, the ability to synthesize and screen in situ DNA constructs of any size or sequence rapidly, accurately and economically is crucial. Today, the process of DNA oligonucleotide synthesis has been automated but the overall development of gene and genome synthesis and error correction technology has far lagged behind that of gene and genome sequencing. What even lagged behind is the capability of screening a large popula

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