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Rozprawy doktorskie na temat „Muscle cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Leskinen, Markus. "Mast cell-mediated apoptosis of smooth muscle cells and endothelial cells." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/leskinen/.

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Woodhouse, Samuel. "The role of Ezh2 in adult muscle stem cell fate." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610201.

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3

Tomc, Lyn Kathryn. "Role of MEF2 proteins in the activation of the c-jun and MCK genes in skeletal muscle /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/MQ56210.pdf.

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4

PESSINA, PATRIZIA. "Necdin enhances muscle reconstitution of dystrophic muscle by mesoangioblast cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7594.

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Improving stem cell therapy is a major goal for the treatment of muscle diseases, where physiological muscle regeneration is progressively exhausted. Mesoangioblasts are vessel-associated stem cells that appear to be the most promising cell type for the cell therapy for muscular dystrophies because of their significant contribution to restoration of muscle structure and function in different muscular dystrophy model. Here we report that MAGE protein Necdin enhances muscle differentiation and regeneration by mesoangioblasts. Indeed, when Necdin is constitutively overexpressed, it accelerates t

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5

Peden, Ryan Stephen Medical Sciences Faculty of Medicine UNSW. "Activation of vascular smooth muscle cells." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/24925.

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Vascular smooth muscle cells (VSMC) in the healthy adult arterial wall are a highlydifferentiated cell type with low levels of proliferation. However, when activated these cells can undergo a phenotypic change to become proliferative, migratory and excrete higher levels of extra-cellular matrix. While this cellular change is an essential element of the adaptable vasculature, excessive proliferation of VSMC underpins the development of a number of disease states, including atherosclerosis and restenosis after balloon angioplasty. The activation of VSMC is dependent on intracellular signalling p

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6

Spendiff, Sally. "Mitochondrial myopathies and muscle stem cells." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1530.

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Mitochondrial myopathies are a group of progressive muscle disorders caused by mutations in the mitochondrial genome (mtDNA) for which there is no effective treatment. Culturing of myoblasts from patients with sporadically occurring mitochondrial diseases has suggested that mtDNA mutations may be lower or absent in muscle stem cells (satellite cells). The activation of muscle satellite cells and subsequent repair of muscle fibres may favourably shift the balance of delete to wild-type (WT) mtDNA, thereby decreasing mtDNA mutation load in affected muscle. This research has investigated muscle p

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7

Iyer, Dharini. "Generation of epicardium and epicardium-derived coronary-like smooth muscle cells from human pluripotent stem cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708997.

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8

Izzard, Tanya. "Extracellular matrix and the cell cycle in vascular smooth muscle cells." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322616.

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9

Holder, Emma L. (Emma Lesley). "Gene expression in muscle tissue and cells." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69755.

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Cellular differentiation is accompanied by the modulation of gene expression. I have compared the expression of various genes, using the slot-blot technique, in two different systems. First, the level of expression of a wide variety of genes was analyzed in the hypertrophied heart of transgenic mice expressing the polyomavirus large T-antigen gene, and compared to normal control heart. I have shown that most changes in gene expression occurred mainly during early stages of heart hypertrophy. These genes code for proteins known to play a role in signal transduction, and transcriptional and grow

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10

Haddad, Mansour Emil Goerge. "GPCRs in rat primary skeletal muscle cells." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/14176/.

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GPCRs are the largest family of proteins in the human genome and a target for huge numbers of therapeutic drugs. However, the role of skeletal muscle in the action of these drugs is unclear. Given the unique importance of GPCR signalling in terms of glucose and fatty acid turnover in other tissues, it would be anticipated that GPCR identified to influence metabolism in these tissues might well be expressed in skeletal muscle. This study investigated the expression of genes encoding GPCRs in skeletal muscle and in cultured preparations thereof. In particular, this study focussed on the expressi

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11

Fernyhough, Melinda. "The growth and development of muscle and fat cells." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Spring2006/m%5Ffernyhough%5F042706.pdf.

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12

Blackwell, Danielle. "The role of Talpid3 in skeletal muscle satellite cells and skeletal muscle regeneration." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66948/.

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The primary cilium has recently been recognised as an essential regulator of the Sonic hedgehog (Shh) signalling pathway. Mutations that disrupt cilia function in humans can cause conditions known as ciliopathies. A wide range of phenotypes is observed in chick and mouse ciliopathy models,including polydactyly, craniofacial defects and polycystic kidneys. The Shh pathway and therefore primary cilia are vital for many developmental processes, including embryonic muscle development, with recent evidence suggesting they may also play a role in adult muscle regeneration. Our studies focus on the T

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13

Liu, Po-shiu Jackie. "Effects of flavonoids on proliferation of breast cancer cells and vascular smooth muscle cells /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480189.

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14

McKilligin, Elaine. "Characterisation and comparison of cell culture models of intimal smooth muscle cells." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624223.

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15

Collins, Charlotte Anne. "An investigation of the stem cell potential of skeletal muscle satellite cells." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446604/.

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Satellite cells are defined by their position beneath the basal lamina of myofibres, and are a source of new myonuclei in adult skeletal muscles. However, other phenotypes also contribute to muscle regeneration, and the relative importance of satellite cells is not known. This work aimed to analyse the stem cell potential of satellite cells by formally investigating their contribution to muscle regeneration. Myofibres isolated from extensor digitorum longus, soleus, and tibialis anterior muscles were found to have respective means of 7,22 and 10 associated satellite cells. When a single myofib

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16

Fakhry, Maya. "Molecular mechanisms of vascular smooth muscle cell transdifferentiation into osteochondrocyte-like cells." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10246.

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Chez les patients souffrant d'insuffisance rénale chronique, les calcifications vasculaires représentent la première cause de mortalité. Elles résultent de la trans-différenciation des cellules musculaires lisses (CMLs) en cellules de type ostéoblastique et/ou chondrocytaire, en réponse à des cytokines inflammatoires ou à une hyperphosphatémie. Les CMLs forment alors des cristaux par l'activité de la phosphatase alcaline non-spécifique du tissu (TNAP). A la lumière de résultats récents, nous avons émis l'hypothèse que la TNAP module la trans différenciation des CMLs. Nos objectifs étaient donc

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17

Govindan, Sriram. "Ca²⁺ signalling in cultured aortic smooth muscle cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609178.

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18

Jump, Seth. "Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6775.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2009.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2009" Includes bibliographical references.

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19

Wang, Yenfeng. "The role of mast cells in foam cell formation, growth inhibition, and apoptosis of smooth muscle cells." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/wang/.

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20

Lee, Jonathan Cheuk Fung. "Intrinsic electrophysiological properties of interstitial cells of Cajal and smooth muscle cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ66217.pdf.

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21

Judson, Robert Neil. "The role of Yes-associated protein (YAP) in skeletal muscle satellite cells and myofibres." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=189444.

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In spite of its post mitotic nature, skeletal muscle maintains remarkable plasticity. Muscle fibres (myofibres) are capable of large alterations in their size as well as an enormous ability to regenerate following injury – thanks to a potent population of resident stem cells (satellite cells). Deciphering the molecular signalling networks responsible for skeletal muscle growth and regeneration is of key scientific interest – not least because of the therapeutic potential these pathways may hold for the treatment of diseases such as muscular dystrophy. In this thesis, the transcriptional co-fac

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22

Tan, Yu Yin Nicole Medical Sciences Faculty of Medicine UNSW. "Gene expression during activation of smooth muscle cells." Publisher:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/43615.

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Cardiovascular disease, which involves the cardiac, cerebrovascular and peripheral vascular system, is the major cause of morbidity and mortality in the western world. Changes in the vascular microenvironment trigger cascades of molecular events involving altered signaling, transcription and translation of a gene. The aim of this thesis was to increase our understanding on the molecular regulation of activated vascular smooth muscle cells. The first study looking at PDGF-D expression provides new insights into the regulatory mechanisms controlling the phosphorylation of Sp1. Studies performed

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23

Seger, Claudia. "Investigations of muscle stem cells in the Zebrafish." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500166.

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24

Shek, Jimmy. "Homogenised models of Smooth Muscle and Endothelial Cells." Thesis, University of Canterbury. Mechanical Engineering, 2014. http://hdl.handle.net/10092/9060.

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Numerous macroscale models of arteries have been developed, comprised of populations of discrete coupled Endothelial Cells (EC) and Smooth Muscle Cells (SMC) cells, an example of which is the model of Shaikh et al. (2012), which simulates the complex biochemical processes responsible for the observed propagating waves of Ca2+ observed in experiments. In a 'homogenised' model however, the length scale of each cell is assumed infinitely small while the population of cells are assumed infinitely large, so that the microscopic spatial dynamics of individual cells are unaccounted for. We wish to

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25

Le, Jeune Ivan Robert. "Phosphodiesterase 4D5 in human airway smooth muscle cells." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408054.

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26

Byrne, Julie Alison. "Mechanisms of damage in isolated skeletal muscle cells." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333620.

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27

Karamariti, Eirini. "Direct reprogramming of fibroblasts into smooth muscle cells." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/direct-reprogramming-of-fibroblasts-into-smooth-muscle-cells(d0feb08f-4d4a-4ded-a2b3-00e41c575cec).html.

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The generation of induced pluripotent stem (iPS) cells is a useful tool for regenerative medicine. However, the risk of tumor development of the aforementioned cells should be addressed before they can be used for clinical applications. During the reprogramming process a number of signal pathways are activated, which may lead to direct differentiation of specific cell lineages prior to the cells reaching the pluripotent state. In order to test this hypothesis we designed a combined protocol of reprogramming and differentiation in an attempt to achieve direct differentiation of fibroblasts to s

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28

McGinley, Susan. "Matters of the Heart: Studying Heart Muscle Cells." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 1995. http://hdl.handle.net/10150/622376.

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29

Addicks, Gregory Charles. "Epigenetic Regulation of Muscle Stem and Progenitor Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37112.

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Epigenetic mechanisms are of fundamental importance for resolving and maintaining cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration and maintenance. Important roles for the trithorax H3K4 histone methyltransferase (HMT) MLL1 have been established for early embryogenesis, and for hematopoietic and neural identity. Here, using a conditional Mll1 knockout

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30

Miller, Zachary Dalton. "Tensile Properties of Single Vaginal Smooth Muscle Cells." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83567.

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Improving treatment and prevention of pelvic organ prolapse, a disorder affecting up to half of parous women, requires thorough mechanical analysis of the vagina and other endopelvic structures at the cellular level. In this study, we tested single vaginal smooth muscle cells (SMCs) to quantify their elastic moduli. Cells were enzymatically isolated from vaginal walls of freshly sacrificed, virgin Long Evans rats and cultured using well-established methods. A custom-built experimental setup was used to perform tensile tests. Micropipettes were fabricated to serve as cantilever-type load cells,

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31

Wang, Xiuyu. "Contractility-induced morphological transitions in smooth muscle cells." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPAST031.

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Les crises cardiaques et les accidents vasculaires cérébraux sont la principale cause de mortalité dans le monde. La resténose et la thrombose sont parmi les complications les plus fréquentes du traitement de l'athérosclérose. Une étude montre que l'étendue des dommages induits par les dispositifs endovasculaires est sensiblement plus élevée pour une paroi artérielle rigide que pour une paroi souple. Les études sur les cellules musculaires lisses montrent que lorsqu'elles atteignent une densité critique, ces cellules peuvent passer spontanément de feuilles cellulaires plates à des amas tridime

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32

Kerr, Tovah Briana. "Discovery and characterization of a novel myostatin in zebrafish." Online access for everyone, 2005. http://www.dissertations.wsu.edu/Thesis/Summer2005/T%5FKERR%5F080505.pdf.

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33

Scharner, Juergen. "Defective adult muscle satellite cells in Zmpste24 deficient mice." Thesis, Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508269.

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34

Richards-Malcolm, Sonia Angela. "THE ROLE OF STEM CELL ANTIGEN-1(Sca-1) IN MUSCLE AGING." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_theses/519.

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Muscle aging is associated with a decrease in the number of satellite cells and their progeny, muscle progenitor cells (MPCs) that are available for muscle repair and regeneration. However, there is an increase in non-immuno-hematopoietic cells (CD45 negative) in regenerating muscle from aged mice characterized by high stem cell antigen -1(Sca-1) expression. In aged regenerating muscle, 14.2% of cells are CD45neg Sca-1pos while 7.2% of cells are CD45neg Sca-1pos in young adult muscle. In vitro, CD45neg Sca-1pos cells over express genes associated with fibrosis, potentially controlled by Wnt2.

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35

Jagadesham, Vamshi Pulloori. "NK cell mediated lysis of vascular smooth muscle cells in abdominal aortic aneurysms." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578645.

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Abdominal aortic aneurysms (AAA) are characterised by a chronic inflammatory infiltrate within the abdominal aortic wall and aortic smooth muscle cell (AoSMC) apoptosis. It is postulated that the inflammatory infiltrate causes AoSMC apoptosis, with resultant aortic wall weakening and aneurysmal degeneration. This putative immune-mediated reaction against aortic wall component suggests that AAA may have features of an auto immune disease. It has been previously demonstrated that natural killer (NK) cells are elevated in the peripheral blood (PB) of AAA patients and display increased cytotoxicit

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36

Yin, Xiaoke. "Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells." Thesis, Queen Mary, University of London, 2006. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1764.

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Embryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process. Mouse ES cells are pre-differentiated by withdrawal of the leukemia inhibitory factor-1 from the culture medium. Subsequently, stem cell antigen-1 positive (Sca-1) cells are sorted by magnetic labelling cell sorting with anti-Sca-1 microbeads and cultured in differentiation medium with or without platelet-derived growth factor (PDGF). Protein extracts of ES cells and Sca-1+ cell

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37

Wang, Ying. "Phenotypic modulations of cultured canine airway smooth muscle cells and growth-arrested cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32279.pdf.

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38

Parris, James Joseph. "Isolation and characterisation of muscle satellite cells from differentiating human embryonic stem cells." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1227.

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Muscular dystrophies are a category of diseases in which the muscle fibres degrade over time. At present there is no known cure, however a great deal of promise exists in cell replacement therapy, which has been successful in alleviating animal models of muscular dystrophy. Unfortunately, attempts to use stem cell therapy to cure or treat muscular dystrophies in humans have been unsuccessful, despite many different approaches to isolating and transplanting potentially myogenic cells. While skeletal muscle differentiation of embryonic stem cells has previously been reported, a simple and effici

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39

Yang, Chian. "Derivation of purified smooth muscle cells from mouse induced pluripotent stem (iPS) cells." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12250.

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Thesis (M.S.)--Boston University<br>Cardiac and vascular disease syndromes and abnormalities have long been the leading causes of death in the United States, but the cause of congenital defects remain unclear due to the lack of appropriate model systems for scientific investigation. Moreover, the predominance of cardiovascular disease has stimulated scientists to focus on developing tissue-engineered blood vessels (TEBV) for vascular reconstruction and replacement. Major challenges remain in generating large amounts of epithelial cells (EC) and vascular smooth muscle cells (VSMC) for vascular

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40

Thumiah-Mootoo, Madhavee. "The Role of Mitophagy in Muscle Stem Cell Fate and Function During Muscle Regeneration." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42239.

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Skeletal muscles have a remarkable capacity to repair and regenerate in response to injury by virtue of their unique population of resident muscle stem cells (MuSCs). Recently, several studies have reported that mitochondria are important regulators of fate and function in various types of stem cells including MuSCs. Furthermore, emerging evidence has shown that accumulation of dysfunctional mitochondria leads to stem cell aging, premature commitment and impaired self-renewal. Preliminary evidence from publicly available transcriptomics datasets processed by our lab showed that Phosphatase and

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41

Whyte, Claire Susan. "The effect of DHA and EPA on fibrosis-related factors in vascular cells." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted access until May 19, 2010, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25877.

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42

Baudry, Stéphane. "Contribution à l'étude de la potentialisation de post-activation et de ses implications fonctionnelles chez l'homme." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210743.

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43

Han, Chih-Lu. "The origin of vascular smooth muscle cells in atherogenesis /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16306.pdf.

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44

廖寶韶 and Po-shiu Jackie Liu. "Effects of flavonoids on proliferation of breast cancer cells and vascular smooth muscle cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011394.

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Stevenson, Meredith J. Fay William P. "Expression of adiponectin receptors by vascular smooth muscle cells." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/5370.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010). Thesis advisor: William P. Fay. Includes bibliographical references

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46

Papaefthymiou, Aikaterini. "Role of the Srf transcription factor in adult muscle stem cells." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB120/document.

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Le muscle squelettique adulte est un tissu avec une grande plasticité étant donné qu’il adapte sa taille suite à la surcharge fonctionnelle et il régénère suite à une lésion. La base de cette plasticité est la myofibre et les cellules souches associées, les cellules satellites (CS). Suite aux stimuli, les CS sortent de la quiescence, elles s’activent, proliférent, s’engagent dans la voie myogénique et fusionnent entre elles ou bien avec la fibre pre-éxistante. Une partie des CS retourne à la quiescence afin de maintenir le « pool » de progéniteurs. Ce projet a pour objectif de mieux caractéris

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47

Piccoli, Martina. "Mouse amniotic fluid stem cells are able to differentiate into satellite cells replenishing the depauperated muscle stem cell niche." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423564.

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Introduction: Stem cell biology has received much interest because of its potential in both therapeutic application and in vitro modeling of diseases. In particular embryonic stem cells have good proliferative and differentiative abilities, but their use is still associated to ethical concerns and problems related to their teratogenic potential. Adult stem cells have also been described to be pluripotent both in vitro and in vivo. However, their use is limited because they are difficult to isolate and expand, particularly in a clinical setting. In this scenario, it would be advantageous to obt

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48

Kaisto, T. (Tuula). "Special features of vesicle trafficking in skeletal muscle cells." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271521.

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Abstract Skeletal muscles are composed of long, multinucleated cells called myofibers, which are highly differentiated cells and therefore unique in structure. In the present study the organization of the endocytic and exocytic pathways in isolated rat skeletal myofibers was defined with confocal and electron microscopic methods. In isolated myofibers the I band areas were shown to be active in endocytosis. The sorting endosomes were distributed in a cross-striated fashion while the recycling and late endosomal compartments were located to perinuclear areas and interfibrillar spaces, where th

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49

Murtuza, Bari. "Interactions between skeletal muscle precursor cells and adult myocardium." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/8427.

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Nally, S. M. "Glucose-induced survival signalling in vascular smooth muscle cells." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273221.

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