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Rozprawy doktorskie na temat „Muscle regeneration”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Ram, Umilla Bettina. "Role of ICL2 in skeletal muscle regeneration." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS058.pdf.

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Le muscle squelettique possède une importante capacité de régénération en réponse aux dommages causés par des blessures, des exercices intensifs ou des myopathies, grâce aux cellules souches musculaires (MuSCs) situées sous la lame basale des fibres en état de quiescence au repos. Suite à une lésion, ces cellules s'activent, prolifèrent et se différencient en myoblastes, lesquels fusionnent pour former de nouveaux myotubes. La régénération musculaire implique également un recrutement de cellules immunitaires qui sont essentielles à l'élimination des débris nécrotiques et au retour à l'homéosta

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Pillitteri, Paul J. "Regeneration of Rat Skeletal Muscle Following a Muscle Biopsy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1118087917.

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Nearing, Marie. "The Role of the Regenerating Protein Family on Skeletal Muscle Regeneration." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/268516.

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Skeletal muscle regeneration is dependent upon the influences of intrinsic and extrinsic factors that stimulate satellite cells. Regenerating proteins are upregulated at the onset of trauma or inflammation in the pancreas, gastrointestinal tract, liver, neural cells and other tissues. Studies have shown that Reg proteins have a mitogenic, anti-apoptotic and anti-inflammatory function in damaged tissues and is necessary for normal progression of regeneration. As skeletal muscle is also able to regenerate itself at a rapid rate, it seems highly likely that Reg proteins function to promote myo

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4

Baker, Brent A. "Characterization of skeletal muscle performance and morphology following acute and chronic mechanical loading paradigms." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5325.

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Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains xii, 270 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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5

Charge, Sophie Barbara Pauline. "Skeletal muscle hypertrophy : its regulation and effect on muscle regeneration." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340500.

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6

Dyer, Kelly Anne. "Chracterisation of Mighty during Skeletal Muscle Regeneration." The University of Waikato, 2006. http://hdl.handle.net/10289/2243.

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Satellite cells are a distinct lineage of myogenic precursors that are responsible for the growth of muscle during post-natal life and for its repair after damage. During muscle growth and regeneration satellite cells are activated in response to growth signals from the environment, which induces the expression of one or both of the two MRFs, Myf-5 or MyoD. Activated satellite cells migrate to the site of injury and proliferate before these transcription factors go on to activate transcription of myogenic genes. The myoblasts can then adopt one of two fates. Some myoblasts initiate terminal di

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7

Markert, Chad D. "Ultrasound and exercise in skeletal muscle regeneration." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1091304498.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 2.

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8

LANGONE, FRANCESCA. "Perturbation of muscle regeneration by small molecules." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/202067.

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Skeletal muscle plays fundamental roles for locomotion, posture maintenance and breathing and to preserve its function, skeletal muscle has developed a remarkable capacity to regenerate also after severe damage. Several studies aimed at understanding the cellular and molecular mechanisms involved in muscle repair that are deregulated in muscular dystrophy-associated fibrosis and in aging-related muscle dysfunction. However, the cellular and molecular effectors of muscle repair remain largely unknown. This doctoral thesis aims at understanding molecular mechanisms and the interplay between diff

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9

Vidal, Iglesias Berta. "The fibrinolitys system in muscle regeneration and dystrophy." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7143.

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Duchenne muscular dystrophy (DMD) is a fatal degenerative disorder of locomotor and respiratory muscles, in which myofibers are progressively replaced by non-muscular fibrotic tissue. Here, we show that fibrin/ogen accumulates in dystrophic muscles of DMD patients and of the mdx mouse model of DMD. Genetic loss or pharmacological depletion of fibrin/ogen in mdx mice attenuated muscular dystrophy progression and improved locomotor capacity. More importantly, fibrin/ogen depletion reduced fibrosis in mdx mouse diaphragm. Our data indicate that fibrin/ogen, through induction of IL-1 Ò, drives the

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10

Chang, C. F. "Studies of muscle regeneration in avian muscular dystrophy." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/38258.

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11

Grasman, Jonathan M. "Designing Fibrin Microthread Scaffolds for Skeletal Muscle Regeneration." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-dissertations/18.

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Volumetric muscle loss (VML) typically results from traumatic incidents; such as those presented from combat missions, where soft-tissue extremity injuries account for approximately 63% of diagnoses. These injuries lead to a devastating loss of function due to the complete destruction of large amounts of tissue and its native basement membrane, removing important biochemical cues such as hepatocyte growth factor (HGF), which initiates endogenous muscle regeneration by recruiting progenitor cells. Clinical strategies to treat these injuries consist of autologous tissue transfer techniques, re

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12

Torres-Palsa, Maria Jose. "ICAM-1 in Skeletal Muscle Disease and Regeneration." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1461860958.

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13

Cezar, Christine Anne. "Magnetically Responsive Biomaterials for Enhanced Skeletal Muscle Regeneration." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467244.

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Skeletal muscle comprises a large percentage of the human body mass and plays an essential role in locomotion, postural support, and breathing. Unfortunately, severe muscle injuries can lead to extensive and irreversible fibrosis, scarring, and loss of function without therapeutic intervention. In these cases, the repair of damaged muscle may be improved by a material system capable of on-demand, spatiotemporally controlled biologic delivery. The hypothesis guiding this thesis is that the regeneration of injured skeletal muscle can be controlled by an active ferrogel scaffold that provides

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14

Blackwell, Danielle. "The role of Talpid3 in skeletal muscle satellite cells and skeletal muscle regeneration." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66948/.

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The primary cilium has recently been recognised as an essential regulator of the Sonic hedgehog (Shh) signalling pathway. Mutations that disrupt cilia function in humans can cause conditions known as ciliopathies. A wide range of phenotypes is observed in chick and mouse ciliopathy models,including polydactyly, craniofacial defects and polycystic kidneys. The Shh pathway and therefore primary cilia are vital for many developmental processes, including embryonic muscle development, with recent evidence suggesting they may also play a role in adult muscle regeneration. Our studies focus on the T

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15

Stumm, Jürgen [Verfasser]. "The role of Osr1 in postnatal muscle development and muscle regeneration / Jürgen Stumm." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1108270980/34.

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16

Girardi, Francesco. "TGFbeta signalling pathway in muscle regeneration : an important regulator of muscle cell fusion." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS114.

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La régénération musculaire s’appuie sur une réserve de cellules souches résidant dans le muscle appelées cellules satellites (MuSCs). Les MuSCs sont quiescentes et peuvent s’activer à la suite d’une blessure du muscle afin de former des progéniteurs amplificateurs (myoblastes) qui se différencieront et fusionneront pour former de nouvelles myofibres. Durant ce processus, un réseau complexe de voies de signalisation est impliqué, parmi lequel la signalisation du facteur de croissance transformant bêta (TGFβ) joue un rôle fondamental. Précédents rapports ont proposé de nombreuses fonctions pour

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17

Pumberger, Matthias [Verfasser]. "Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration / Matthias Pumberger." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1127046098/34.

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18

Nishimura, Daigo. "Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration." Kyoto University, 2015. http://hdl.handle.net/2433/199212.

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19

Mañas, García Laura 1991. "Disuse muscle atrophy and cachexia : a step forward on muscle regeneration and therapeutic opportunities." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671029.

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La atrofia muscular por desuso en el contexto de las enfermedades crónicas, como enfermedades respiratorias, cáncer o un reposo prolongado, se caracteriza por la pérdida de masa y función muscular. Además, el desgaste muscular asociado a la caquexia cancerosa, puede verse agravado tras un período de desuso muscular. Un tratamiento con compuestos polifenólicos como la curcumina o el resveratrol puede atenuar la pérdida de masa muscular. En esta tesis, un modelo de inmovilización de una extremidad trasera en ratones, dio lugar a una disminución del peso y función en el músculo gastrocnemi

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20

Thumiah-Mootoo, Madhavee. "The Role of Mitophagy in Muscle Stem Cell Fate and Function During Muscle Regeneration." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42239.

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Skeletal muscles have a remarkable capacity to repair and regenerate in response to injury by virtue of their unique population of resident muscle stem cells (MuSCs). Recently, several studies have reported that mitochondria are important regulators of fate and function in various types of stem cells including MuSCs. Furthermore, emerging evidence has shown that accumulation of dysfunctional mitochondria leads to stem cell aging, premature commitment and impaired self-renewal. Preliminary evidence from publicly available transcriptomics datasets processed by our lab showed that Phosphatase and

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21

Cahill, Kevin Scott. "Enhancement of stem-cell transplantation strategies for muscle regeneration." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002319.

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22

Ellison, Georgina May. "Myocyte death and regeneration in cardiac and skeletal muscle." Thesis, Liverpool John Moores University, 2004. http://researchonline.ljmu.ac.uk/5638/.

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23

Cote, Lauren E. (Lauren Esther). "The instructive roles of muscle cells in planarian regeneration." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122066.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from student-submitted PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Regeneration requires both new cell production and patterning information to correctly place new tissue. Planarians are flatworms with remarkable capacity to regenerate after nearly any injury and to indefinitely maintain tissue homeostasis. Dividing cells, ne

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24

Chaturvedi, Vishal. "Role of extracellular matrix in muscle repair and regeneration." Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/1381.

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Extracellular matrices (ECMs) play important structural and mechanical roles in muscle tissue. They are also critical for normal muscle homeostasis, but it is poorly understood how individual matrix proteins, or the mix of ECM proteins found in vivo affect myoblast behaviour. Aspects of this question have been examined in this thesis using both matrices from skeletal muscle and artificial scaffolds prepared from silk proteins. The ability of these surfaces to support myoblast proliferation and differentiation was examined using a murine myoblast cell line and primary human skeletal muscle myob

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25

Cazin, Coralie. "Dissecting the impact of cellular senescence on muscle regeneration." Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS070.pdf.

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La régénération tissulaire est un processus de remplacement des cellules perdues ou endommagées lors d'une blessure. La sénescence cellulaire est une réponse physiologique au stress caractérisée par un arrêt du cycle cellulaire stable. Mon doctorat vise à étudier la sénescence in vivo lors de la régénération musculaire, y compris son identité, ses fonctions et sa dynamique. Nous avons précédemment démontré que la sénescence induite par blessure favorise la reprogrammation dans le muscle squelettique. Mon projet vise à étudier la biologie de la sénescence lors de la régénération musculaire de m

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26

Desgeorges, Thibaut. "Crosstalk of Glucocorticoid Receptor and AMP-activated protein kinase in macrophages during skeletal muscle regeneration." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1058.

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Le muscle strié squelettique régénère ad integrum après une lésion aigüe stérile grâce aux cellules satellites qui sont les cellules souches du muscle strié squelettique. L'inflammation, et notamment les macrophages, joue un rôle important durant ce processus. En effet, après une lésion, les monocytes sanguins infiltrent le tissu et deviennent des macrophages avec un phénotype pro-inflammatoire associé à la lésion. Ces macrophages phagocytent les débris cellulaires et promeuvent la prolifération des cellules souches musculaires. Ensuite, les macrophages changent leur phénotype vers un phénotyp

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27

Feno, Simona Santina. "Physiopathological characterization of the role of MCUb in skeletal muscle regeneration." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427268.

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Calcium ions play key roles in different intracellular mechanisms, ranging from biological processes such as proliferation, gene transcription, protein post-translational modifications and aerobic metabolism to physiological mechanisms such as muscle contraction, exocytosis, energy metabolism, chemotaxis and synaptic plasticity during learning and memory [1,2]. Key players in the spatio-temporal regulation of cytosolic calcium concentrations ([Ca2+]cyt) are mitochondria, intracellular organelles that can accumulate Ca2+ in the very rapid time-scale of hundreds of milliseconds [3] and reach val

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28

Rosenblatt, Jonathan David. "Regeneration of rat extensor digitorum longus muscle injected with bupivacaine." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292277.

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29

Acharyya, Swarnali. "Elucidating molecular mechanisms of muscle wasting in chronic diseases." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180096565.

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Saini, Amarjit. "The molecular and cellular aspects of muscle degeneration and regeneration." Thesis, Manchester Metropolitan University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585529.

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The concept of skeletal muscle homeostasis - often viewed as the net balance between two separate processes, namely protein degradation and protein synthesis - are not occurring independently of each other, but are finely co-ordinated by a web of intricate signalling networks (Nader, 2005). Such signalling networks are in charge of executing environmental and cellular cues that ultimately determine whether muscle proteins are synthesised or degraded. Prolonged elevations of proinflammatory cytokines are closely associated with muscle wasting that occurs during the sarcopenia of ageing and in c

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31

Bryers, P. S. "Regeneration and differentiation of muscle from normal and dystrophic mice." Thesis, University of Newcastle Upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374843.

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McBrier, Nicole M. "Influence of post-injury ultrasound treatments on skeletal muscle regeneration." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1122916468.

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Šustová, Hana. "Effects of Ghrelin peptides on skeletal and cardiac muscle regeneration." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/104070.

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The thesis is divided in two parts. Part I describes effects of unacyated ghrelin, a small peptide mainly produced by stomach with multiple biological effects, on muscle regeneration in dystrophic condition using the murine mdx model. This study shows that unacylated ghrelin stimulates the polarity complex-mediated assymetric division of satellite cells, stem cells of muscle, leading to increase regenerative potential of satellite cells that in turn leads to the reduction of muscle degeneration and overall improvement of muscle function. These data were published in "Unacylated ghrelin enhance

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34

Winn, Nadine Stephanie. "The differential role of insulin-like growth factor-1 isoforms in skeletal muscle." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-70111.

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35

Shahriyari, Mina [Verfasser]. "Engineered skeletal muscle from human pluripotent stem cells to model muscle disease and regeneration / Mina Shahriyari." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/123640176X/34.

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Geiger, Ashley Elizabeth. "Impacts of dietary obesity on muscle stem cell behaviors." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/87757.

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Occurrence of obesity has steadily increased in the human population and, along with it, associated health complications such as systemic insulin resistance, which can lead to the development of type 2 diabetes mellitus. Obesity is a complex metabolic disorder that often leads to chronic inflammation and an overall decline in human and animal health. In mouse skeletal muscle, obesity has been shown to impair muscle regeneration after injury, however, the mechanism underlying these changes in satellite cell (SC) biology have yet to be explored. To test the negative impacts of obesity on SC b

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Galletta, Eva. "Role of macrophagic factors in muscle regeneration: in vitro and in vivo characterization." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423103.

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Muscle regeneration is a complex process that involves many different types of cells, both myogenic and non-myogenic. In particular, macrophages play a fundamental role, since they exert many different functions: they phagocyte fiber debris, release cytokines to regulate the inflammatory response and stimulate satellite cells through the secretion of myogenic factors. Importantly, inflammatory processes mediated by macrophages are known to play a major role in the pathophysiology of many inherited muscular dystrophies, such as Duchenne Muscular Dystrophy (DMD). There are two main classes of a

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Clark, Kim Michelle. "Mitochondrial DNA disease : pathogenesis and treatment." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262993.

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Sesodia, S. "The effect of denervation and reinnervation on the regeneration of mammalian skeletal muscle." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370636.

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Makridakis, Jennifer Lynn. "Braided Collagen Microthreads as a Cell Delivery System in Bioengineered Muscle Regeneration." Digital WPI, 2010. https://digitalcommons.wpi.edu/etd-theses/1112.

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"Engineered muscle tissue offers a promising solution for the treatment of large muscle defects. Three-dimensional tissue engineered matrices, such as microthreads, can be used to grow new myofibers that will reduce scar formation and integrate easily into native myofibers. We hypothesize that adsorbing growth factors to the surface of braided collagen scaffolds using crosslinking strategies will promote muscle derived fibroblastic cell (MDFC) attachment and growth, which will serve as a platform for delivering cells to large muscle defects for muscle regeneration. To test this hypothesis, sel

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Lunn, Elizabeth Ruth. "Studies on the degeneration and regeneration of neurons to skeletal muscle." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292675.

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Snyder, Benjamin J. "Immunological Aspects of Muscle Injury and Regeneration in Young and Old Rats." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1016641263.

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Trignol, Aurélie. "The extracellular matrix as a biomaterial to optimize skeletal muscle regeneration." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1029.

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Le muscle strié squelettique possède de grandes capacités de régénération grâce à ses cellules souches, les cellules satellites. Après une lésion, le processus de régénération musculaire qui se met en place est finement régulé dans le temps et l’espace par le microenvironnement, constitué de cellules avoisinantes mais également par des éléments de la matrice extracellulaire (MEC). Cette dernière se compose de molécules structurales comme les collagènes et de composants possédant un rôle trophique comme les glycosaminoglycanes (GAGs). La MEC musculaire est peu étudiée à cause d’une organisation

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Ding, Can. "The influence of Notch over-stimulation on muscle stem cell quiescence versus proliferation, and on muscle regeneration." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066399/document.

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La transplantation de cellules souches de muscle possède un grand potentiel pour la réparation à long terme du muscle dystrophique. Cependant, la croissance ex vivo des cellules souches musculaires réduit de manière significative l'efficacité de leur greffe puisque le potentiel myogénique est considérablement réduit lors de la mise en culture. La voie de signalisation Notch a émergé comme un régulateur majeur des cellules souches musculaires (MuSCs) et il a également été décrit que la sur-activation de Notch est crucial pour le maintien du caractère souche des MuSC. Cette découverte pourrait ê

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Ding, Can. "The influence of Notch over-stimulation on muscle stem cell quiescence versus proliferation, and on muscle regeneration." Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066399.

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La transplantation de cellules souches de muscle possède un grand potentiel pour la réparation à long terme du muscle dystrophique. Cependant, la croissance ex vivo des cellules souches musculaires réduit de manière significative l'efficacité de leur greffe puisque le potentiel myogénique est considérablement réduit lors de la mise en culture. La voie de signalisation Notch a émergé comme un régulateur majeur des cellules souches musculaires (MuSCs) et il a également été décrit que la sur-activation de Notch est crucial pour le maintien du caractère souche des MuSC. Cette découverte pourrait ê

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Alfaro, Leslie Ann So. "Characterization of the role of CD34 in adult skeletal muscle regeneration." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39344.

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Expression of the cell surface sialomucin CD34 is common to many adult stem cell types, including muscle satellite cells. However, no clear stem cell or regeneration-related phenotype has ever been reported in mice lacking CD34, and its function on these cells remains poorly understood. Here, we assess the functional role of CD34 on satellite cell-mediated muscle regeneration. Using an optimized flow cytometry-based method to analyze myogenic progenitors, we show that CD34’s expression is tightly regulated early during the muscle regeneration process. Following this, we show that Cd34⁻/⁻ mice,

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47

Georgiadis, Vassilios. "The role of galectin-1 in skeletal muscle development and regeneration." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488604.

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Galectin-1 is a p-galactoside binding lectin that has been implicated in a variety of cellular processes in different tissues, including skeletal muscle. Initial studies investigating the phenotype of a null mouse model for galectin-1 suggested that there were no obvious differences between the musculature of the null mouse and that of the wild-type mouse. However, in vitro studies suggested that the addition of galectin-1 Improved the fusion of myoblasts to myotubes and caused dermal fibroblasts to convert to the myogenic lineage.

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Griger, Joscha [Verfasser]. "Shp2 functions in postnatal skeletal muscle growth and regeneration / Joscha Griger." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1096221233/34.

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Holmes, Roisin Anne. "Development of biomimetic hydrogels as cell-laden devices for muscle regeneration." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19346/.

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The aim of this thesis was to develop a novel cross-linking strategy to prepare defined collagen-based hydrogel networks to investigate stiffness-induced cell differentiation for skeletal muscle tissue engineering. Volumetric muscle loss (VML) occurs with traumatic injury or aggressive tumour ablation and results in a diminished natural capacity for repair. Whilst autologous muscle transfer offers the gold standard treatment option, the level of success is limited by surgical expertise, availability of healthy tissue, donor site morbidity and a loss of muscle strength and function due to scar

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Owens, Daniel John. "The role of vitamin D in skeletal muscle function and regeneration." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4391/.

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Skeletal muscle is a direct target for the group of seco-steroids collectively termed Vitamin D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis et al., 2014b). Crucially, the Vitamin D receptor (VDR) is also present in skeletal muscle (Srikuea, Zhang, Park-Sarge, & Esser, 2012) and upon exposure, binds to its ligand 1α-25[OH]2D3 and initiates genomic and non-genomic rapid signalling responses. At present there is a global prevalence of low s

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