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Rozprawy doktorskie na temat „Mycobacterium bovis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Roring, Solvig Mary Margaret. "DNA fingerprinting of Mycobacterium bovis." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287426.

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2

Mardare, Cornelia. "Interactions of Mycobacterium bovis with protozoa and the occurrence of Mycobacterium bovis in environmental protozoa." Thesis, University of Surrey, 2010. http://epubs.surrey.ac.uk/844633/.

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Bovine tuberculosis is in the UK a persistent disease, affecting cattle and badgers. The latter is suspected to be a reservoir for Mycobacterium bovis but the transmission between badgers and cattle remains unclear. Mycobacteria have been shown to survive ingestion by protozoa and some even multiplied inside amoebas. The aim of this study was to investigate some interactions of Acanthamoeba castellanii and Tetrahymena pyriformis with M bovis. Firstly, the long term survival of the bacilli in protozoa was monitored. Secondly, it was investigated whether bacilli internalized in protozoa cysts ar

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3

Sales, Mariana Lázaro. "Identificação de Mycobacterium bovis e Mycobacterium tuberculosis por PCR." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/SMOC-9L2PT7.

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Mycobacterium bovis and Mycobacterium tuberculosis are the causative agents of bovine and human tuberculosis, respectively. The standard diagnosis is based on the isolation and identification of bacterial colonies through biochemical methods. These methodologies in addition to being costly, require an environment with high level of biosecurity and a great time of cultivation and tests to obtain the results. The molecular tests based on the principles of real-time PCR using the fluorophore Eva Green were efficient in the identification of M. bovis and M. tuberculosis. In addition, analyses were

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4

Hamerman, Jessica Ann. "Macrophage activation during Mycobacterium bovis BCG infection /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8359.

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5

Michell, Stephen Lloyd. "Molecular characterisation of a novel lipoglycoprotein from Mycobacterium tuberculosis and Mycobacterium bovis." Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/7477.

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In Great Britain a recent independent scientific review into bovine tuberculosis concluded that the best prospect for control of TB in the national herd is to develop a vaccine. The secreted antigens of the Mycobacterium tuberculosis complex have received much interest as possible vaccine candidates due to their ability to confer protection against tuberculosis in small animal models. The recent discovery that some of these mycobacterial antigens are glycosylated, a modification ubiquitous in eukaryotic proteins, may provide some novel insights into the properties of these antigens. The antige

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6

Rennie, Bryan D. "Detection and identification of antigens from Mycobacterium bovis culture filtrate with immune sera from Mycobacterium bovis sensitized or infected cattle." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28138.

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Bovine tuberculosis, caused by Mycobacterium bovis, infects approximately 50 million cattle worldwide and is diagnosed by the tuberculin skin test (TST). The purpose of this thesis was to characterise the culture filtrate proteins (CFP) of M. bovis PPD tuberculin and to compare the antibody response of M. bovis infected versus M. bovis sensitized cattle. Sterile filtered PPD tuberculin (SF-PPD) resolved into approximately 200 discrete spots using two-dimensional PAGE. While 2D Western blot analysis of both M. bovis sensitized and M. bovis infected cattle sera demonstrated an antibody boost f

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7

Bouchez-Zacria, Malika. "Rôles de l’environnement et des contacts intra et interspécifiques dans la transmission de Mycobacterium bovis dans le système bovins-blaireaux en Pyrénées-Atlantiques – Landes." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS552/document.

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En France, pays officiellement indemne de tuberculose bovine depuis 2001, l’infection persiste dans certaines zones, dont les Pyrénées-Atlantiques-Landes, où les niveaux d’infection observés chez les bovins et les blaireaux font craindre un fonctionnement particulier de ce système multi-hôtes pour Mycobacterium bovis, agent de la tuberculose bovine. L’objectif de cette thèse a été de mieux comprendre les mécanismes de transmission de M. bovis au sein du système bovins-blaireaux dans cette zone. L’analyse statistique du risque d’infection localement concomitante chez les blaireaux et les bovins

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8

Whiteford, Danelle. "Stress survival in Mycobacterium tuberculosis and Mycobacterium bovis and the role of hup in Mycobacterium smegmatis." Pullman, Wash. : Washington State University, 2008. http://www.dissertations.wsu.edu/Dissertations/Fall2008/D_Whiteford_100908.pdf.

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9

Young, Jamie Stuart. "Molecular detection of Mycobacterium bovis in the environment." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/47689/.

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An investigation was carried out to determine the presence and persistence of Mycobacterium bovis in the environment. Soil samples were taken in April 2000 from a farm in Ireland which had undergone a bovine tuberculosis outbreak some four months prior. Total community DNA was extracted from these samples and PCR carried out targeted to two genes specific for the Mycobacterium tuberculosis complex; mpb64 and mpb70. These genes were detected in soil samples taken from entrances to two badger sets and in soil from two sites where the infected cattle grazed. Further analysis of DNA using oligonuc

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10

Sales, Erica Bravo. "Genotipagem de Mycobacterium bovis pelo multispacer sequence typing." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-8YGH2X.

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Mycobacterium bovis, which causes bovine tuberculosis, is a species belonging to Mycobacterium tuberculosis complex. It shows 99.9% of genetic homology with other species of the complex, making the diagnosis difficult. The bovine bacilli represent a serious problem due to the direct losses in cattle, caused by such infirmity and possible sanitary barriers to exportation. Molecular typing, provide an innovative way to identify bacterial strains, trough generate while genotypes by combining different polymorphic DNA markers, contributing to their epidemiological investigation. The techniques cur

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11

Mpongoshe, Vuyiseka. "Gene expression changes in macrophages infected with pathogenic M. tuberculosis and non-pathogenic M. smegmatis and M. bovis BCG." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86729.

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Thesis (MScMedSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The current anti-TB drugs have had success in decreasing the number of deaths caused by TB, however, this success is limited by the emergence of drug resistant TB strains. Therefore, a novel TB therapy that limits the development of resistance has become necessary in an attempt to effectively control TB. The anti-TB drugs directly target mycobacterial enzymes, and potentiate the development of this resistance, and have therefore provided the rationale for this study. The aim was therefore to identify host macrophage genes t

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12

Tschiginewa, Valeria [Verfasser]. "Regulation der C-Quellenverwertung in Mycobacterium tuberculosis und Mycobacterium bovis BCG / Valeria Tschiginewa." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2015. http://d-nb.info/1076828485/34.

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13

Himpens, Sabine. "Caractérisation du système à deux composants SenX3/RegX3 de Mycobacterium tuberculosis et Mycobacterium bovis BCG." Lille 1, 1999. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1999/50376-1999-159.pdf.

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Les mécanismes contrôlant la virulence mycobactérienne sont encore peu connus. Pour étudier ces mécanismes, les systèmes de transduction sensorielle à deux composants constituent une cible privilégiée. Nos recherches ont permis de cloner des gènes codant des éléments de systèmes à deux composants chez Mycobacterium tuberculosis et Mycobacterium bovis BCG appelés senX3 et regX3. Ce système appartient à la famille des couples PhoB/PhoR et PhoP/PhoQ, impliqués dans la virulence chez diverses bactéries pathogènes. Nous avons produit ces deux protéines sous une forme recombinante chez Escherichia c

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14

Baudoin, Norbert. "Tuberculose trachéale pseudo-tumorale à mycobacterium bovis : à propos d'un cas avec revue de la littérature." Montpellier 1, 1988. http://www.theses.fr/1988MON11273.

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15

Tadayon, K. "Molecular epidemiology of Mycobacterium bovis in cattle in Iran." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590987.

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<i>Mycobacterium bovis</i> causes bovine tuberculosis (BTB) that is an endemic disease of cattle in Iran. Despite benefiting from a successful test-and-slaughter programme, initiated in the late 1960s, which has reduced the prevalence to 0.05% (reactors in tuberculinated cattle) in 2006, there is little known about the epidemiology of <i>M. bovis</i> in Iran. The present study sought to improve this serious lack of information through combining traditional diagnostic methods (tuberculin tests in the field, mean inspections in abattoirs and microbiology in the laboratory) with modern molecular

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16

Carroll, Maria Veronica. "Interaction of innate immune proteins with mycobacterium bovis BCG." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526549.

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17

Duarte, Elsa Maria Leclerc. "Tuberculose bovina: detecção molecular e genotipagem de Mycobacterium bovis." Doctoral thesis, Universidade de Évora, 2008. http://hdl.handle.net/10174/12147.

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Nesta dissertação, pretendeu-se avaliar e aplicar um conjunto de ferramentas moleculares a estirpes de Mycobacterium bovis e Mycobacterium caprae, com o objectivo de melhorar o diagnóstico da tuberculose bovina e de proceder à primeira genotipagem destas estirpes em Portugal, clarificando vias de transmissão e a eventual existência de reservatórios silvestres. A extracção de DNA por disrupção mecânica/ lise enzimática e o PCR-REA gyrB produziram resultados que permitiram aumentar a sensibilidade e especificidade do diagnóstico, e identificar um conjunto aleatório de isolados (N=293), de várias

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18

Walrath, Jessica R. "The role of alpha 4 beta 1 integrin (VIa-4) in recruitment of mycobacterium tuberculosis-specific TH1-LIKE recall responses to the human lung." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1196182534.

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19

Rocha, Vivianne Cambuí Mesquita. "Discriminação de isolados de Mycobacterium bovis pelas técnicas de Spoligotyping, MIRU e ETR e suas aplicações epidemiológicas." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-25022010-113545/.

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O Mycobacterium bovis é o agente causador da tuberculose em bovinos, zoonose que produz prejuízos para a produção de carne e leite em muitos países. Para apoiar estudos epidemiológicos no âmbito dos programas de controle, recentemente surgiram vários métodos de discriminação molecular de isolados de M. bovis. Os mais utilizados são o Spoligotyping, Mycobacterial Interspersed Repetitive Units (MIRU) e Exact Tandem Repeat (ETR), que apresentam diferentes poderes de discriminação. No presente estudo calculou-se a diversidade alélica para cada locus de MIRU e de ETR e o índice discriminatório de H

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20

Rocha, Vivianne Cambuí Figueiredo. "Avaliação do Spoligotyping, MIRU-VNTR e Multispacer Sequence Typing na discriminação de isolados autóctones de Mycobacterium bovis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22082014-160432/.

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A tuberculose continua sendo uma importante doença infecciosa, tanto nos humanos quanto nos animais, com índices de morbidade e mortalidade significativos e perdas econômicas em todo o mundo. A tuberculose bovina é uma doença infecciosa causada pela bactéria Mycobacterium bovis, que gera perdas na produção nos rebanhos infectados, sendo também considerada uma importante zoonose. Os métodos de diagnóstico direto têm fundamental importância para um sistema de vigilância para a tuberculose bovina e a agregação de métodos moleculares, notadamente aqueles que têm aplicação em epidemiologia, traz ma

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21

Zimpel, Cristina Kraemer. "Sequenciamento, anotação e análise do genoma completo de Mycobacterium bovis cepa SP38." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-25072017-120925/.

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A tuberculose é uma doença infectocontagiosa causada por bactérias do complexo Mycobacterium tuberculosis (MTBC) que afeta humanos e/ou animais. Membros desse complexo evoluíram clonalmente e possuem grande similaridade genômica, diferenciando-se por polimorfismos de nucleotídeo único (SNPs) e regiões de diferença (RDs). Dentre os patógenos da tuberculose em animais, Mycobacterium bovis, causador da tuberculose bovina, é o membro do MTBC de maior importância global. Desta maneira, o presente estudo tem por objetivo o sequenciamento, a anotação e a análise da estirpe brasileira SP38 de M. bovis

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22

Ferreira, Emerson Ramalho. "A revacinação com a BCG modula a produção de citocinas frente a antígenos do Mycobacterium leprae, em contatos menores de 15 anos de pacientes com hanseníase." reponame:Repositório Institucional da UFC, 2010. http://www.repositorio.ufc.br/handle/riufc/4787.

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FERREIRA, Emerson Ramalho. A revacinação com a BCG modula a produção de citocinas frente a antígenos do Mycobacterium leprae, em contatos menores de 15 anos de pacientes com hanseníase. 2010. 104 f. Dissertação (Mestrado em Microbiologia Médica) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2010.<br>Submitted by denise santos (denise.santos@ufc.br) on 2013-04-29T13:37:28Z No. of bitstreams: 1 2010_dis_erferreira.pdf: 2370142 bytes, checksum: 0b5a10a59056f54a2a9027b3e71e0163 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernandes@gmail.com) on 2013-0

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23

Tuffal, Gilles. "Analyse structurale et fonctionnelle des lipopolyméthylglucoses de Mycobacterium bovis BCG." Toulouse 3, 1995. http://www.theses.fr/1995TOU30281.

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La paroi des mycobacteries joue un role majeur dans la survie intramacrophagique des mycobacteries pathogenes telles que mycobacterium tuberculosis, l'agent etiologique de la tuberculose. Elle contient une forte proportion d'acides mycoliques, supposes former une barriere physique relativement impermeable aux molecules hydrophiles et en particulier aux antibiotiques polaires. Bien que les etapes clef de la biosynthese des acides mycoliques soient connues, aucun schema de biosynthese ne specifie l'origine des acides gras precurseurs. Ces derniers pourraient provenir du cytoplasme ou leur biosyn

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Venisse, Anne. "Caractéristiques structurales et fonctionnelles du lipoarabinomannane de Mycobacterium bovis BCG." Toulouse 3, 1994. http://www.theses.fr/1994TOU30025.

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Le lipoarabinomannane (lam) est un antigene majeur de la paroi des mycobacteries et les fonctions biologiques attribuees au lam de mycobacterium tuberculosis le designent comme un immunomodulateur important de la reponse immunitaire de l'hote, voire comme un des facteurs de virulence de ce pathogene. L'objet de nos travaux a ete d'etablir la structure du lam de m. Bovis bcg, souche a la virulence attenuee utilisee comme vaccin antituberculeux, et d'etudier ses proprietes fonctionnelles comparativement a celles du lam d'une souche virulente de m. Tuberculosis. Les analyses par rmn bidimensionne

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PHILIPP, WOLGANG. "Organisation genomique de mycobacterium tuberculosis et de m. Bovis bcg." Paris 7, 1995. http://www.theses.fr/1995PA077246.

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Mycobacterium tuberculosis, l'agent causant la tuberculose humaine est la premiere source de mortalite due a un agent infectieux. Depuis une decennie, le developpement et l'application des outils de la biologie moleculaire ont bien fait progresser la recherche sur cet organisme qui etait auparavant difficilement abordable. Dans ce memoire nous decrivons la construction des cartes genomiques d'une souche virulente de m. Tuberculosis, la souche de reference h37rv, ainsi que pour la souche vaccinale m. Bovis bcg pasteur. Une carte integree du genome de m. Tuberculosis h37rv a ete realisee a l'aid

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Abbas, Rabiya. "Genetic basis of survival of Mycobacterium bovis inside Acanthamoeba castellanii." Thesis, University of Surrey, 2011. http://epubs.surrey.ac.uk/843112/.

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Tuberculosis remains a major threat to human health accounting for 2 million annual deaths worldwide. M. bovis causes TB in cattle which is a serious issue in the UK. Mycobacteria are widely distributed in the environments that are also colonized by free living amoebae. In the present study, free-living amoeba (A. castellanii) has been used to study the genetic factors required for the intracellular survival of M. bovis. Role of region of difference 1 (RD1), isocitrate lyase (Rv0467), ClgR (Rv2745) and the VapC (Rv2548) toxin-antitoxin system was examined for survival in amoebae. While the rol

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Lima, Cristiane. "Análise funcional do regulador transcricional Rv3405c em Mycobacterium bovis BCG." reponame:Repositório Institucional da FIOCRUZ, 2013. https://www.arca.fiocruz.br/handle/icict/8057.

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Made available in DSpace on 2014-07-22T16:59:27Z (GMT). No. of bitstreams: 4 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 69450.pdf: 2409202 bytes, checksum: abdfee4e0aec1730b503aba8f1bb3000 (MD5) 69450.pdf.txt: 208978 bytes, checksum: 6549c0a44ac6d8e45b4998656b86fa86 (MD5) 69450.pdf.jpg: 1330 bytes, checksum: e4f720b175db53a9cb553b3e194b93d6 (MD5) Previous issue date: 2014-05-07<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, Brasil<br>Em 2011 foram notificados quase 9 milhões de novos casos de tuberculose (TB), culminando em aproximadamen

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Gallant, James Luke. "The effect of glutamate homeostasis on the survival of M. bovis BCG." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97831.

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Thesis (MScMedSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of the tuberculosis disease, is estimated to infect a third of the world’s population and is therefore, arguably, the most successful human pathogen in recorded history. Immense efforts to understand the genetic factors and biochemical processes underlying the complex interactions between M. tuberculosis and its host cells have delivered staggering insights into the profound proficiency by which this bacterium establishes and maintains an infection. It is now clear that M. tub

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Blankenheim, Thalita Masoti [UNESP]. "Resposta à tuberculinização em bovinos sensibilizados com inóculos inativados de Mycobacterium avium e de Mycobacterium bovis." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/141991.

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Submitted by THALITA MASOTI BLANKENHEIM null (thalita09@hotmail.com) on 2016-07-29T13:08:15Z No. of bitstreams: 1 Tese completa.pdf: 5020011 bytes, checksum: 62948c1c86e4a7526cfcb52b6727ce24 (MD5)<br>Rejected by Ana Paula Grisoto (grisotoana@reitoria.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo a orientação abaixo: O arquivo submetido não contém o certificado de aprovação. A versão submetida por você é considerada a versão final da dissertação/tese, portanto não poderá ocorrer qualquer alteração em seu conteúdo após a aprovação. Corrija esta informação e

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Blankenheim, Thalita Masoti. "Resposta à tuberculinização em bovinos sensibilizados com inóculos inativados de Mycobacterium avium e de Mycobacterium bovis /." Jaboticabal, 2016. http://hdl.handle.net/11449/141991.

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Orientador: Luis Antonio Mathias<br>Banca: Anna Monteiro Correia Lima<br>Banca: Adolorata Aparecida Bianco Carvalho<br>Banca: Raphaella Barbosa Meirelles Bartoli<br>Banca: Samir Issa Samara<br>Resumo: A tuberculose causada pelo Mycobacterium bovis é uma importante doença dos bovinos e constitui um grande problema de saúde animal, podendo também atingir humanos. Para o diagnóstico da infecção, e para desencadear as medidas sanitárias decorrentes desse diagnóstico, o Programa Nacional de Controle e Erradicação de Brucelose e Tuberculose (PNCEBT) estabelece a utilização de testes intradérmicos de

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Sigola, Lynnette Brenda. "The role of innate immunity in the host response to Mycobacterium bovis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265950.

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Kanno, Alex Issamu. "Expressão de antígenos de Schistosoma mansoni em BCG recombinante." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-14052014-095103/.

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O BCG é um bacilo atenuado de Mycobacterium bovis atualmente investigado na expressão de antígenos heterólogos. Genes oriundos de vírus, bactérias e parasitas são clonados em vetores de expressão micobacterianos e a partir deles, são geradas cepas de BCG recombinante, rBCG. Duas cepas micobacterianas, BCG e M. smegmatis, demonstraram a expressão do antígeno SmStoLP-2 e animais imunizados com este BCG não demonstra diferença na proteção contra a infecção por cercárias, apesar da resposta imune diferenciada. A otimização do códon de SmTSP-2 e SmVAL-5 permitiu sua expressão em M. smegmatis recomb

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Dib, Cristina Corsi. "Utilização de uma técnica rápida para o isolamento de Mycobacterium bovis a partir de amostras de leite experimentalmente inoculadas." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-13082007-103556/.

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A técnica de camada delgada em placas com meio de Middlebrook 7H11 foi comparada com a técnica padrão de cultura em meio de Stonebrink, a fim de se avaliar a sensibilidade e o tempo de detecção de micobactérias em amostras de leite, experimentalmente inoculadas com Mycobacterium bovis (estirpe AN5), em uma diluição 10-2, e submetidas a duas diferentes técnicas de processamento, utilizando-se da gordura (técnica 1)e do sedimento (técnica 2), descontaminadas pelo método de Petroff modificado (adicionado de Tween 80) e confrontadas com a técnica do leite total submetida ao método de Petroff e sem

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Morato, Flávia. "Avaliação da atividade micobactericida de desinfetantes químicos utilizando a técnica de cultivo em camada de ágar Middlebrook 7H11." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15082007-093534/.

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Avaliou-se a atividade micobactericida de cinco desinfetantes químicos frente a uma estirpe de Mycobacterium bovis isolada de caprinos, tipificada por PCR (polymerase chain reaction) e com 32 dias de cultivo no meio de Stonebrink. O teste de desinfetantes foi realizado utilizando-se a técnica de cultivo em camada delgada de ágar Middlebrook 7H11 modificado e foi comparado ao teste em tubos com meio de Stonebrink, tradicionalmente utilizado no laboratório de zoonoses bacterianas da FMVZ/USP. Os cinco desinfetantes ensaiados foram: \"A\" : grupo controle; \"B\" - hipoclorito de sódio (2,5 % de

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Ambrosio, Simone Rodrigues. "Métodos bacteriológicos aplicados à tuberculose bovina: comparação de três métodos de descontaminação e de três protocolos para criopreservação de isolados." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-31102006-162337/.

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Dada a importância do Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose (PNCEBT), a necessidade de uma eficiente caracterização bacteriológica dos focos como ponto fundamental do sistema de vigilância e as dificuldades encontradas pelos laboratórios quanto aos métodos de isolamento de Mycobacterium bovis fizeram crescer o interesse do meio científico por estudos, sobretudo moleculares, de isolados M. bovis. Para a realização dessas técnicas moleculares, é necessária abundância de massa bacilar, obtida através da manutenção dos isolados em laboratório e repiques em meios de

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Agunso, Camila Noia. "Enriquecimento seletivo para pesquisa de Mycobacterium bovis em leite e queijo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042014-162454/.

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O Mycobacterium bovis causa a tuberculose bovina, doença zoonótica que propaga, provavelmente com baixa prevalência, em todo o território nacional e pode ser transmitida pelo leite. A adoção sistemática da pasteurização do leite contribuiu para a redução dos casos humanos da doença, mas em alguns países, como o Brasil, é comum o consumo de leite cru e de seus derivados, o que pode contribuir para ocorrência de casos humanos. A participação desse agente nos atuais índices de tuberculose humana, cujo principal agente é o M. tuberculosis, é pouco investigada, mas acredita-se que seja maior do que

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Patiño, Suaza Ana Eugenia. "Comparación de métodos para el diágnostico de Mycobacterium bovis en Chile." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/145135.

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Tesis para optar al Grado de Magíster en Ciencias Animales y Veterinarias mención Medicina Preventiva Animal.<br>Con el objetivo de implementar métodos que disminuyan los tiempos de respuesta diagnóstica y por ende proporcionen rapidez en la emisión del resultado de tuberculosis bovina, se evaluaron y compararon los resultados obtenidos por los métodos BACTEC MGIT 960, cultivo bacteriológico en medio Stonebrink (ST), reacción en cadena de la polimerasa en tiempo real (RT-PCR), e Histopatología. Todo el trabajo se realizó en el Laboratorio de Micobacterias del Subdepartamento Laboratorios y Es

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Whelan, Adam Owen. "Development and optimisation of reagents for the discrimination of Mycobacterium Bovis infected from M. Bovis BCG infected cattle." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270776.

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Barbier, Elodie. "Prévalence de Mycobacterium bovis dans les agroécosystèmes : analyse de réservoirs environnementaux potentiels (sol, eau douce, faune du sol et faune aquatique) et traçage de la circulation de cette bactérie entre les différents compartiments." Thesis, Dijon, 2016. http://www.theses.fr/2016DIJOS026/document.

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La tuberculose bovine est une maladie infectieuse contagieuse causée par Mycobacterium bovis. Cette maladie touche les bovins et de nombreuses espèces de mammifères domestiques et sauvages, ainsi que l’homme. La circulation de la bactérie dans des systèmes multi-hôtes variés favorise l’entretien de la maladie et la contamination des bovins vivant à proximité des animaux sauvages infectés. En marge de la transmission directe de M. bovis par voie respiratoire, la transmission indirecte aux bovins, liée à l’inhalation ou à l’ingestion de matrices environnementales contaminées par un animal infect

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Morar, Darshana. "Development of ELISAs for the detection of interferon-gamma in rhinoceroses and elephants as diagnostic tools for Mycobacterium bovis and Mycobacterium tuberculosis infections." Thesis, Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-12032009-193314/.

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Rodrigues, Lívia de Andrade. "Inativação do Mycobacterium bovis (espoligotipo BR024) em creme de leite submetido à alguns parâmetros comerciais de pasteurização." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-10022011-080624/.

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A resistência térmica dos microrganismos sofre influência, entre outros fatores, das características do agente e das características do substrato, como o teor de gordura. Um dos objetivos da pasteurização do creme é a eliminação dos patógenos eventualmente presentes no leite. Entretanto, não há padrão de tempo e temperatura de pasteurização para este produto na legislação. O Mycobacterium bovis é considerado o patógeno não formador de esporo de maior resistência térmica que pode normalmente ser transmitido pelo leite. Assim, este trabalho se propõe a avaliar a inativação de Mycobacterium bovis

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Amaral, Eduardo Pinheiro. "Avaliação da virulência micobacteriana e modulação da resposta imune durante a infecção por isolados clínicos de Mycobacterium bovis e Mycobacterium tuberculosis." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-26102011-153630/.

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A tuberculose é considerada um problema emergente de saúde pública. Este estudo tem como objetivo avaliar a associação da patogenicidade/virulência e propriedades imunomoduladoras de isolados clínicos de Mbv (cepas B2 e MP287/03) e Mtb (cepa Beijing 1471), e da cepa de Mtb H37Rv, como referência de virulência. Os isolados, MP287/03 e Beijing 1471, apresentaram maior virulência em relação às demais cepas, levando os camundongos à morte ainda na fase aguda de infecção. Foi verificada baixa produção de mediadores pró-inflamatórios nos animais infectados com o isolado MP287/03, enquanto nos infect

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Pothi, Radhika. "Global analysis of gene regulation in Mycobacterium bovis (BCG) and Streptomyces coelicolor." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/811050/.

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Streptomyces coelicolor and Mycobacterium bovis are high G+C gram-positive members of the phylum Actinobacteria. M. bovis is a member of the M. tuberculosis species complex and M. bovis, BCG is the attenuated vaccine strain used as a model organism as it can be manipulated in containment Category 2 laboratories. When cells are exposed to different environments/stresses they need to adapt their physiology and biochemistry for their effective survival. A key mechanism of adaptation is the ability to quickly alter the molecular composition of the cell through the regulation of gene expression bot

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Wooff, Emine Esen. "The application of functional genomics to understand the virulence of Mycobacterium bovis." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407184.

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Taylor, Stephanie Jemma. "The role of protozoa and nematodes in the survival of Mycobacterium bovis." Thesis, University of Surrey, 2003. http://epubs.surrey.ac.uk/802/.

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Benton, Clare Helen. "Spatio-temporal distribution and persistence of Mycobacterium bovis in a badger population." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/28495.

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Studying the dynamics of pathogen transmission within wildlife populations presents an array of challenges. Where populations are socially structured, this can influence parasite transmission, impacting on the effectiveness of disease management strategies. In this thesis, I focus on a well-studied social mammal, the European badger (Meles meles) which is a key wildlife reservoir of a disease of economic importance; bovine TB (caused by infection with Mycobacterium bovis). The social structuring, characteristic of high density badger populations, is of well-established importance in the transm

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Rodrigues, Gabriel Santos Cruz. "Papel da obesidade na imunomodulação da infecção experimental por Mycobacterium bovis BCG." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/730.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-02-15T13:08:10Z No. of bitstreams: 1 gabrielsantoscruzrodrigues.pdf: 1333283 bytes, checksum: 46d4dabb8192501d9b5b879ecdd9a3e4 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-02-26T12:23:19Z (GMT) No. of bitstreams: 1 gabrielsantoscruzrodrigues.pdf: 1333283 bytes, checksum: 46d4dabb8192501d9b5b879ecdd9a3e4 (MD5)<br>Made available in DSpace on 2016-02-26T12:23:19Z (GMT). No. of bitstreams: 1 gabrielsantoscruzrodrigues.pdf: 1333283 bytes, checksum: 46d4dabb8192501d9b5b879ecdd9a3e4 (MD5)

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Beckley, Nicholas. "Epidemiological dynamics of Mycobacterium bovis and population suppression in badgers (Meles meles)." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/49412.

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Bovine TB in cattle is a major economic problem in the UK, costing the government approximately £100m a year. Badgers are a wildlife host of the infection that causes bovine TB, and there is strong evidence that they transmit the infection to cattle. Understanding the ecology and epidemiology of infected badger populations is therefore crucial for implementing disease management strategies relating to badgers. Genetic and phenotypic data of badgers captured during a large-scale field trial of repeated, widespread badger culls were used to assess the importance of parental roles on the impacts

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Brown, Julian A. "Transmission of bovine tuberculosis (Mycobacterium bovis) from badgers (Meles meles) to cattle." Thesis, University of Bristol, 1993. http://hdl.handle.net/1983/d277aaf1-a1b1-4142-b0e5-ffa1f3d12bb7.

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Delmas, Carole. "Analyse structurale comparative des lipoarabinomannanes de quatre souches de Mycobacterium bovis BCG." Toulouse 3, 1997. http://www.theses.fr/1997TOU30134.

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Depuis les annees 20, mycobacterium bovis bcg (bacille calmette-guerin) est le vaccin vivant utilise pour la protection antituberculeuse. Pourtant, l'existence d'une variabilite, de 0 a 80%, de la protection antituberculeuse induite par ce vaccin demontre clairement une derive des souches de bcg actuellement utilisees. Un composant majeur des parois mycobacteriennes, le lipoarabinomannane ou lam est suppose, aujourd'hui, etre un facteur determinant dans l'infection et la survie intramacrophagique des mycobacteries, etapes necessaire a la mise en place d'une immunite protectrice par le bcg. L'o

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