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Artykuły w czasopismach na temat „Myo-inositol 1”

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Data publikacji: 6 września 2023

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1

Rodrigues, Marta V., Nuno Borges, Mafalda Henriques, et al. "Bifunctional CTP:Inositol-1-Phosphate Cytidylyltransferase/CDP-Inositol:Inositol-1-Phosphate Transferase, the Key Enzyme for Di-myo-Inositol-Phosphate Synthesis in Several (Hyper)thermophiles." Journal of Bacteriology 189, no. 15 (2007): 5405–12. http://dx.doi.org/10.1128/jb.00465-07.

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ABSTRACT The pathway for the synthesis of di-myo-inositol-phosphate (DIP) was recently elucidated on the basis of the detection of the relevant activities in cell extracts of Archaeoglobus fulgidus and structural characterization of products by nuclear magnetic resonance (NMR) (N. Borges, L. G. Gonçalves, M. V. Rodrigues, F. Siopa, R. Ventura, C. Maycock, P. Lamosa, and H. Santos, J. Bacteriol. 188:8128-8135, 2006). Here, a genomic approach was used to identify the genes involved in the synthesis of DIP. Cloning and expression in Escherichia coli of the putative genes for CTP:l-myo-inositol-1

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2

Stephens, L. R., R. R. Kay, and R. F. Irvine. "A myo-inositol d-3 hydroxykinase activity in Dictyostelium." Biochemical Journal 272, no. 1 (1990): 201–10. http://dx.doi.org/10.1042/bj2720201.

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A soluble ATP-dependent enzyme which phosphorylates myo-inositol has been characterized in Dictyostelium. The myo-inositol kinase activity was partially purified from amoebae by chromatography on DEAE-Sepharose and phenyl-Sepharose columns. The product of both the partially purified activity and of a crude cytosolic fraction was myo-inositol 3-phosphate. The partially purified preparations of myo-inositol kinase (a) possessed a Km for myo-inositol of 120 microM (in the presence of 5 mM-ATP) and for ATP of 125 microM (in the presence of 1 microM-myo-inositol), (b) did not recognize allo-, epi-,

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3

Burtle, G. J., and R. T. Lovell. "Lack of Response of Channel Catfish (Ictalurus punctatus) to Dietary Myo-inositol." Canadian Journal of Fisheries and Aquatic Sciences 46, no. 2 (1989): 218–22. http://dx.doi.org/10.1139/f89-030.

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Channel catfish (Ictalurus punctatus) fingerlings were fed for 28 wk in aquaria (28 ± 1 °C) on semipurified diets with supplemental myo-inositol (400 mg∙kg diet−1), without myo-inositol, and without myo-inositol but with succinylsulfathiazole to suppress intestinal bacteria synthesis. Omission of myo-inositol from the diet, with or without the antibiotic, did not reduce growth rate, produce overt signs of myo-inositol deficiency, or cause a decrease in tissue (muscle, liver, and brain) concentration of myo-inositol. No lipid accumulation occurred in liver or kidney when myoinositol was deleted

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4

Stephens, L. R., P. T. Hawkins, A. F. Stanley, et al. "myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate." Biochemical Journal 275, no. 2 (1991): 485–99. http://dx.doi.org/10.1042/bj2750485.

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1. Standard and high-performance anion-exchange-chromatographic techniques have been used to purify myo-[3H]inositol pentakisphosphates from various myo-[3H]inositol-prelabelled cells. Slime mould (Dictyostelium discoideum) contained 8 microM-myo-[3H]inositol 1,3,4,5,6-pentakisphosphate, 16 microM-myo-[3H]inositol 1,2,3,4,6-pentakisphosphate and 36 microM-D-myo-[3H]inositol 1,2,4,5,6-pentakisphosphate [calculated intracellular concentrations; Stephens & Irvine (1990) Nature (London) 346, 580-583]; germinating mung-bean (Phaseolus aureus) seedlings contained both D- and L-myo-[3H]inositol 1

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5

Offer, J., J. C. Metcalfe, and G. A. Smith. "The uptake of 3H-labelled monodeoxyfluoro-myo-inositols into thymocytes and their incorporation into phospholipid in permeabilized cells." Biochemical Journal 291, no. 2 (1993): 553–60. http://dx.doi.org/10.1042/bj2910553.

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Monodeoxyfluoro-myo-inositols were applied to electropermeabilized and intact thymocyte preparations to study their metabolism and uptake in order to investigate their suitability as potential inhibitors of phosphoinositide-mediated cellular responses. Only three of the monodeoxyfluoro-myo-inositols were incorporated into the phospholipids of thymocytes: 1D-3-deoxy-3-fluoro-myo-inositol, 5-deoxy-5-fluoro-myo-inositol and 1D-6-deoxy-6-fluoro-myo-inositol, all of which were weaker substrates for phosphatidylinositol synthase than was myo-inositol. The 3-, 5- and 6-fluoro analogues also behaved a

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6

Lamosa, Pedro, Luï¿½s G. Gonï¿½alves, Marta V. Rodrigues, Lï¿½gia O. Martins, Neil D. H. Raven, and Helena Santos. "Occurrence of 1-Glyceryl-1-myo-Inosityl Phosphate in Hyperthermophiles." Applied and Environmental Microbiology 72, no. 9 (2006): 6169–73. http://dx.doi.org/10.1128/aem.00852-06.

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ABSTRACT The accumulation of compatible solutes was studied in the hyperthermophilic bacterium Aquifex pyrophilus as a function of the temperature and the NaCl concentration of the growth medium. Nuclear magnetic resonance analysis of cell extracts revealed the presence of α- and β-glutamate, di-mannosyl-di-myo-inositol phosphate, di-myo-inositol phosphate, and an additional compound here identified as 1-glyceryl-1-myo-inosityl phosphate. All solutes accumulated by A. pyrophilus are negatively charged at physiological pH. The intracellular levels of di-myo-inositol phosphate increased in respo

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7

Biffen, M., and D. E. Hanke. "Reduction in the level of intracellular myo-inositol in cultured soybean (Glycine max) cells inhibits cell division." Biochemical Journal 265, no. 3 (1990): 809–14. http://dx.doi.org/10.1042/bj2650809.

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Although myo-inositol is included in media for the successful growth of plant tissues, the actual requirement of most tissues, including soybean (Glycine max) callus in suspension culture, for myo-inositol has not been demonstrated. We have made use of deoxyglucose to reduce intracellular levels of myo-inositol. Deoxyglucose is phosphorylated to deoxyglucose 6-phosphate, which inhibits L-myo-inositol 1-phosphate synthase, an important enzyme in the synthesis of myo-inositol. Addition of deoxyglucose to the medium resulted in a decrease in the intracellular level of myo-inositol that correspond

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8

SIU, TEVA, and GREGORY A. AHEARN. "Inositol Transport by Hepatopancreatic Brush-Border Membrane Vesicles of the Lobster Homarus Americanus." Journal of Experimental Biology 140, no. 1 (1988): 107–21. http://dx.doi.org/10.1242/jeb.140.1.107.

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The mechanism of [3H]myo-inositol transport by the lobster hepatopancreas was examined using purified brush-border membrane vesicles. Transport was stimulated by a 100 mmoll−1 inward Na+ gradient, but other cation gradients were ineffective, suggesting a Na+-dependent transfer mechanism. The transport system was most efficient at pH7.0 (both sides), rather than in the presence of a pH gradient (pHin = 7.0; pHout = 5.5) or at bilaterally low pH (pHin = pHout = 5.5). The system was shown to be electrogenic in two different ways. First, myo-inositol uptake was stimulated by anions of increasing p

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9

Martin, K. L., and T. K. Smith. "The myo-inositol-1-phosphate synthase gene is essential in Trypanosoma brucei." Biochemical Society Transactions 33, no. 5 (2005): 983–85. http://dx.doi.org/10.1042/bst0330983.

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The de novo synthesis of myo-inositol occurs via a two-step process: first, glucose 6-phosphate is converted into inositol 1-phosphate by an INO1 (myo-inositol-1-phosphate synthase; EC 5.5.1.4); then, it is dephosphorylated by an inositol monophosphatase. The myo-inositol can then be incorporated into PI (phosphatidylinositol), which is utilized in a variety of cellular functions, including the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. A putative INO1 was identified in the Trypanosoma brucei genome database and, by recombinant expression in Escherichia coli, was shown to be a

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10

Borges, Nuno, Luís G. Gonçalves, Marta V. Rodrigues, et al. "Biosynthetic Pathways of Inositol and Glycerol Phosphodiesters Used by the Hyperthermophile Archaeoglobus fulgidus in Stress Adaptation." Journal of Bacteriology 188, no. 23 (2006): 8128–35. http://dx.doi.org/10.1128/jb.01129-06.

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ABSTRACT Archaeoglobus fulgidus accumulates di-myo-inositol phosphate (DIP) and diglycerol phosphate (DGP) in response to heat and osmotic stresses, respectively, and the level of glycero-phospho-myo-inositol (GPI) increases primarily when the two stresses are combined. In this work, the pathways for the biosynthesis of these three compatible solutes were established based on the detection of the relevant enzymatic activities and characterization of the intermediate metabolites by nuclear magnetic resonance analysis. The synthesis of DIP proceeds from glucose-6-phosphate via four steps: (i) gl

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11

Stephens, L. R., P. T. Hawkins, A. J. Morris, and P. C. Downes. "l-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase." Biochemical Journal 249, no. 1 (1988): 283–92. http://dx.doi.org/10.1042/bj2490283.

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Homogenates of primary-cultured murine bone macrophages contain an enzyme capable of synthesizing myo-[3H]inositol pentakisphosphate from myo-[3H]inositol tetrakisphosphate fractions derived from myo-[3H]inositol-labelled mouse macrophages and chick erythrocytes. D-myo-inositol 1,3,4,5-tetrakis[32P]-phosphate present in the same incubations was not phosphorylated. Since the myo-[3H]inositol-labelled tetrakisphosphate fractions used as substrates consist of a mixture of L-myo-inositol 1,4,5,6-tetrakisphosphate (60-85%) and a periodate-resistant tetrakisphosphate(s) whose characteristics are con

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12

Higgins, B. D., and M. T. Kane. "Inositol transport in mouse embryonic stem cells." Reproduction, Fertility and Development 17, no. 6 (2005): 633. http://dx.doi.org/10.1071/rd05021.

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The uptake of myo-inositol by mouse embryonic stem (ES) cells was measured using [2-3H]myo-inositol. Uptake of myo-inositol by ES cells occurred in a mainly saturable, sodium-, time- and temperature-dependent manner, which was inhibited by glucose, phloridzin and ouabain. Self inhibition by inositol was much greater than inhibition by glucose indicating that transport was not occurring via a sodium-dependent glucose transporter. Uptake rate was much greater than efflux rate indicating a mainly unidirectional transport mechanism. Estimated kinetics parameters for sodium-dependent inositol uptak

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13

Nagata, Katsumi, Naohiro Hori, Kenzo Sato, Kunimasa Ohta, Hideaki Tanaka, and Yasutake Hiji. "Cloning and functional expression of an SGLT-1-like protein from the Xenopus laevisintestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 5 (1999): G1251—G1259. http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1251.

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A cDNA encoding an Na+-glucose cotransporter type 1 (SGLT-1)-like protein was cloned from the Xenopus laevis intestine by the 5′- and 3′-rapid amplification of cDNA ends method. The deduced amino acid sequence was 673 residues long, with a predicted mass of 74.1 kDa and 52–53% identity to mammalian SGLT-1s. This gene was expressed in the small intestine and kidney, reflecting a tissue distribution similar to that of SGLT-1. The function of the protein was studied using the two-microelectrode voltage-clamp technique after injection of cRNA into Xenopus laevis oocytes. Perfusion with myo-inosito

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14

NIGOU, Jérôme, and Gurdyal S. BESRA. "Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis." Biochemical Journal 361, no. 2 (2002): 385–90. http://dx.doi.org/10.1042/bj3610385.

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Mycobacterium tuberculosis and related members of the genus Mycobacterium contain a number of inositol-based lipids, such as phosphatidylinositol mannosides, lipomannan and lipoarabinomannan. The synthesis of phosphatidylinositol in M. smegmatis is essential for growth and myo-inositol is a key metabolite for mycobacteria. Little is known about the biosynthesis of inositol in mycobacteria and the only known de novo pathway for myo-inositol biosynthesis involves a two-step process. First, cyclization of glucose 6-phosphate to afford myo-inositol 1-phosphate via inositol-1-phosphate synthase and

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15

Duthu, Brigitte, Douraid Houalla, and Robert Wolf. "Phosphoranylation de polyols: Voie d'accès aux phosphates d'intérêt biologique. I. Cas du myo-inositol." Canadian Journal of Chemistry 66, no. 12 (1988): 2965–74. http://dx.doi.org/10.1139/v88-461.

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An original method for the phosphorylation of an unprotected myo-inositol is described, which yields several myo-inositol phosphates at the same time. The reaction proceeds via a partial or complete phosphoranylation of the cyclitol by means of the aminobicyclophosphane 8, followed by oxidation of the resulting bicyclophosphoranes bearing a P—H bond and acid hydrolysis of the neutral phosphates thus formed. In the case of the tris-phosphoranylation we identified, among the HPLC fractions, the myo-inositol-1,2-(cycl)phosphate 22, the myo-inositol-1-phosphate 23, and the myo-inositol-2-phosphate

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16

deSolms, S. Jane, Joseph P. Vacca, and Joel R. Huff. "The total synthesis of (±)-myo-inositol-1,3,4-trisphosphate, (±)-myo-inositol-2,4,5-trisphosphate and (±)-myo-inositol-1,3,4,5-tetrakisphosphate." Tetrahedron Letters 28, no. 39 (1987): 4503–6. http://dx.doi.org/10.1016/s0040-4039(00)96548-1.

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17

Feth, F., R. Wagner, H. Baydoun, V. Wray, and KG Wagner. "Medium scale production of L‐myo‐inositol 1‐phosphate." Biotechnology and Applied Biochemistry 12, no. 4 (1990): 364–69. http://dx.doi.org/10.1111/j.1470-8744.1990.tb00108.x.

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L‐myo‐Inositol‐1‐phosphate synthetase was purified from baker's yeast, grown in a fermenter in an inositol‐deficient medium and analyzed using a new HPLC assay for inositol. This enzyme was used in a procedure, developed from methods partially described in the literature, for the medium scale production and purification of L‐myo‐inositol 1‐phosphate. The identity and purity of the product were confirmed by 1H and 31P NMR spectroscopy.

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18

Groenen, Pascal M. W., Hans M. W. M. Merkus, Fred C. G. J. Sweep, Ron A. Wevers, Fokje S. M. Janssen, and Régine P. M. Steegers-Theunissen. "Kinetics of myo-inositol loading in women of reproductive age." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 1 (2003): 79–85. http://dx.doi.org/10.1258/000456303321016213.

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Background: Myo-inositol plays a key role in an important intracellular signalling pathway. A deranged myo-inositol metabolism has been associated with neural tube defects. A myo-inositol loading test was performed to investigate the kinetics in healthy women of reproductive age. Methods: Five healthy non-obese females {mean age (standard deviation: SD) 22·8 (2·2) years} were recruited at the University Medical Center Nijmegen. Blood samples were drawn fasting and at 20, 40, 60, 90, 180 and 270 min after ingestion of 100 mg/kg body weight of myo-inositol. Urine samples were collected before my

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19

Daniellou, Richard, Hongyan Zheng, and David RJ Palmer. "Kinetics of the reaction catalyzed by inositol dehydrogenase from Bacillus subtilis and inhibition by fluorinated substrate analogs." Canadian Journal of Chemistry 84, no. 4 (2006): 522–27. http://dx.doi.org/10.1139/v06-033.

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Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis catalyzes the oxidation of myo-inositol to scyllo-inosose by transfer of the equatorial hydride of the substrate to NAD+. This is a key enzyme in the metabolism of myo-inositol, a primary carbon source for soil bacteria. In light of our recent discovery that the enzyme has a broad substrate spectrum while maintaining high stereoselectivity, we seek a more thorough understanding of the enzyme and its active site. We have examined the kinetics of the recombinant enzyme, and synthesized fluorinated substrate analogues as competitive inhi

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20

Watkins, Oliver C., Mohammed Omedul Islam, Preben Selvam, et al. "Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants." Journal of Endocrinology 243, no. 1 (2019): 73–84. http://dx.doi.org/10.1530/joe-19-0267.

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We postulate that myo-inositol, a proposed intervention for gestational diabetes, affects transplacental lipid supply to the fetus. We investigated the effect of myo-inositol on fatty acid processing in human placental explants from uncomplicated pregnancies. Explants were incubated with 13C-labeled palmitic acid, 13C-oleic acid and 13C-docosahexaenoic acid across a range of myo-inositol concentrations for 24 h and 48 h. The incorporation of labeled fatty acids into individual lipids was quantified by liquid chromatography mass spectrometry. At 24 h, myo-inositol increased the amount of 13C-pa

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21

Placidi, Martina, Giovanni Casoli, Carla Tatone, Giovanna Di Emidio, and Arturo Bevilacqua. "Myo-Inositol and Its Derivatives: Their Roles in the Challenges of Infertility." Biology 13, no. 11 (2024): 936. http://dx.doi.org/10.3390/biology13110936.

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Myo-inositol (MYO) and D-chiro-inositol (DCI) are the two most significant isomeric forms of inositol, playing a critical role in intracellular signaling. MYO is the most abundant form of inositol in nature; DCI is produced from MYO through epimerization by an insulin-dependent enzyme. Recently, it has been demonstrated that inositol may influence oocyte maturation and improve intracellular Ca2+ oscillation in the oocytes, and it has been proposed as a potential intervention for restoring spontaneous ovulation. The MYO concentration in human follicular fluid is considered a bioindicator of ooc

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Korkmaz, S., A. Sait, and AG Keleş. "In vitro investigation of the efficacy of myo-inositol (vitamin B8) as an antioxidant and preservative additive for feed safety." Journal of the Hellenic Veterinary Medical Society 76, no. 1 (2025): 8597–606. https://doi.org/10.12681/jhvms.35879.

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The study was carried out to examine the safety and potential activities of myo-inositol as an antioxidant, preservative, hygiene enhancer, and antiviral feed additive in pet nutrition. For this purpose, the antioxidant capacity of myo-inositol was expressed as vitamin C equivalent antioxidant capacity (VCEAC) by MTT assay. The cytotoxic concentration of 50% (CC50) was measured by the linearity between myo-inositol concentrations and the viability of mammalian kidney and liver cell lines. The virucidal and antiviral activities of myo-inositol were determined by the virus titration method on th

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23

DURMAZ, Yaşar, and Gökhun Çağatay ERBİL. "Effects of myo-inositol concentration on growth and pigments of Nannochloropsis oculata culture." Ege Journal of Fisheries and Aquatic Sciences 37, no. 2 (2020): 195–99. http://dx.doi.org/10.12714/egejfas.37.2.11.

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Inositols are used as growth promoting agents over plants. But microalgae are different from higher plant especially photosynthetic efficiency and productivity. According to the results of this study, myo-inositol addition to the culture medium of Nannochloropsis oculata provides higher cell densities. 100 mg L-1 myo-inositol added experimental group was reached to 1.42 fold cell mL-1, while the 500 mg L-1 myo-inositol added group was reached to 1.28 fold cell mL-1 than the control group. Mean chlorophyll a per cell amounts were calculated for experimental groups and control groups as 0.052 pg

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Jin, Jean Huaqian, and Andreas Seyfang. "High-affinity myo-inositol transport in Candida albicans: substrate specificity and pharmacology." Microbiology 149, no. 12 (2003): 3371–81. http://dx.doi.org/10.1099/mic.0.26644-0.

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Inositol is considered a growth factor in yeast cells and it plays an important role in Candida as an essential precursor for phospholipomannan, a glycophosphatidylinositol (GPI)-anchored glycolipid on the cell surface of Candida which is involved in the pathogenicity of this opportunistic fungus and which binds to and stimulates human macrophages. In addition, inositol plays an essential role in the phosphatidylinositol signal transduction pathway, which controls many cell cycle events. Here, high-affinity myo-inositol uptake in Candida albicans has been characterized, with an apparent K m va

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Kalmbach, Catherine R., Brian J. Rude, Morgan E. Brown, and Thiago Martins. "115 Solubility and degradation of human fertility-promoting molecules in a rumen environment." Journal of Animal Science 102, Supplement_1 (2024): 105–6. http://dx.doi.org/10.1093/jas/skae019.118.

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Abstract Endometrial epithelial of cows conceiving was associated to gene set enrichment of pathways associated to synthesis, metabolism, and degradation of myo-inositol pathways (Physiol. Genomics 54: 71-85, 2022). Progesterone-modulated transcription also indicated an increase in oxidative phosphorylation pathways in the endometrial epithelial of cows. Thus, modulation of myo-inositol and oxidative phosphorylation pathways can favor conception rates in cattle. Oral supplementation with pyrroloquinoline Quinone (PQQ), an antioxidant, and inositol isomers (myo- and D-chiro-inositol) has been p

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Krings, Eva, Karin Krumbach, Brigitte Bathe, et al. "Characterization of myo-Inositol Utilization by Corynebacterium glutamicum: the Stimulon, Identification of Transporters, and Influence on l-Lysine Formation." Journal of Bacteriology 188, no. 23 (2006): 8054–61. http://dx.doi.org/10.1128/jb.00935-06.

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ABSTRACT Although numerous bacteria possess genes annotated iol in their genomes, there have been very few studies on the possibly associated myo-inositol metabolism and its significance for the cell. We found that Corynebacterium glutamicum utilizes myo-inositol as a carbon and energy source, enabling proliferation with a high maximum rate of 0.35 h−1. Whole-genome DNA microarray analysis revealed that 31 genes respond to myo-inositol utilization, with 21 of them being localized in two clusters of >14 kb. A set of genomic mutations and functional studies yielded the result that some genes

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Dumschott, Kathryn, Julie Dechorgnat, and Andrew Merchant. "Water Deficit Elicits a Transcriptional Response of Genes Governing d-pinitol Biosynthesis in Soybean (Glycine max)." International Journal of Molecular Sciences 20, no. 10 (2019): 2411. http://dx.doi.org/10.3390/ijms20102411.

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d-pinitol is the most commonly accumulated sugar alcohol in the Leguminosae family and has been observed to increase significantly in response to abiotic stress. While previous studies have identified genes involved in d-pinitol synthesis, no study has investigated transcript expression in planta. The present study quantified the expression of several genes involved in d-pinitol synthesis in different plant tissues and investigated the accumulation of d-pinitol, myo-inositol and other metabolites in response to a progressive soil drought in soybean (Glycine max). Expression of myo-inositol 1-p

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Xue-ping, Yin, Guo Fei-fei, Sun Xiangrong, and Xu Luo. "The Effects of Myo-inositol on Glucose Metabolic in Diabetes Rats." International Journal of Sciences Volume 7, no. 2018-04 (2018): 71–76. https://doi.org/10.5281/zenodo.3350289.

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Objective: To observe the myo-inositol on normal and diabetic rats muscle and intestinal glucose uptake. Methods: The rat jejunum was placed in Kb with containing 2.5% -20% myo-inositol and the glucose concentration was detected at 0 and 2 h. The psoas muscle was placed in Kb containing 2.5% -20% myo-inositol Kb (with or without insulin) the glucose concentration was detected at 0 and 1 h. Rats were divided into blank control group, normal muscle myo-inositol group, blank control group of diabetic rats, myo-inositol group of diabetic rats and acarbose group of diabetic rats (DBA) The intestina

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Van Lookeren Campagne, M. M., C. Erneux, R. Van Eijk, and P. J. M. Van Haastert. "Two dephosphorylation pathways of inositol 1,4,5-trisphosphate in homogenates of the cellular slime mould Dictyostelium discoideum." Biochemical Journal 254, no. 2 (1988): 343–50. http://dx.doi.org/10.1042/bj2540343.

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Dictyostelium discoideum homogenates contain phosphatase activity which rapidly dephosphorylates Ins(1,4,5)P3 (D-myo-inositol 1,4,5-trisphosphate) to Ins (myo-inositol). When assayed in Mg2+, Ins(1,4,5)P3 is dephosphorylated by the soluble Dictyostelium cell fraction to 20% Ins(1,4)P2 (D-myo-inositol 1,4-bisphosphate) and 80% Ins(4,5)P2 (D-myo-inositol 4,5-bisphosphate). In the particulate fraction Ins(1,4,5)P3 5-phosphatase is relatively more active than the Ins(1,4,5)P3 1-phosphatase. CaCl2 can replace MgCl2 only for the Ins(1,4,5)P3 5-phosphatase activity. Ins(1,4)P2 and Ins(4,5)P2 are both

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Latif, Nurmeen, Seema Rajar, Mehreen Yousuf, Sadaf Imtiaz, Sidrah Abbas, and Zara Jamali. "Comparison of Efficacy between Myo-Inositol versus Metformin in Women with Polycystic Ovary Syndrome." Life and Science 5, no. 1 (2024): 06. http://dx.doi.org/10.37185/lns.1.1.486.

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Objective: To compare the effectiveness of myo-inositol versus metformin in treating women with polycystic ovary syndrome.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Gynae Unit II, Dr. Ruth. K.M. Pfau th th Civil Hospital Karachi, Pakistan from 7 February 2019 to 6 August 2019.Methods: All eligible patients who visited the hospital were enrolled. The group-Aincluded females who received myo-inositol (n=35), whereas the group-B included females who received metformin (n=35). Females in the myo-inositol group were administered 1

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Zhang, Xinjun, Xian Wang, Wenna Zhang, and Qing Chen. "Combined Application of Myo-Inositol and Corn Steep Liquor from Agricultural Waste Alleviate Salt Stress in Brassica rapa." Plants 12, no. 24 (2023): 4110. http://dx.doi.org/10.3390/plants12244110.

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Salinity poses a significant threat to plant growth through induction of osmotic and ionic stress and disruption of nutrient absorption. Biostimulants derived from agricultural waste offer a sustainable solution to alleviate salt-induced damage to plants and contribute to a circular and sustainable economy. In this study, we applied a combination of myo-inositol and corn steep liquor from waste sources to seedling cabbage (Brassica rapa subsp. pekinensis) and investigated their effects on plant growth under NaCl-simulated salt stress. Different concentrations of myo-inositol and corn steep liq

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Raboy, Victor. "myo-Inositol-1,2,3,4,5,6-hexakisphosphate." Phytochemistry 64, no. 6 (2003): 1033–43. http://dx.doi.org/10.1016/s0031-9422(03)00446-1.

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Yorek, Mark A., Joyce A. Dunlap, Michael J. Thomas, Patrick R. Cammarata, Cheng Zhou та William L. Lowe. "Effect of TNF-α on SMIT mRNA levels andmyo-inositol accumulation in cultured endothelial cells". American Journal of Physiology-Cell Physiology 274, № 1 (1998): C58—C71. http://dx.doi.org/10.1152/ajpcell.1998.274.1.c58.

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Previously we have shown that hyperosmolarity increases Na+- myo-inositol cotransporter (SMIT) activity and mRNA levels in cultured endothelial cells. Because hyperosmolarity and cytokines, such as tumor necrosis factor-α (TNF-α), activate similar signal transduction pathways, we examined the effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation. In contrast to the effect of hyperosmolarity, TNF-α caused a time- and concentration-dependent decrease in SMIT mRNA levels and myo-inositol accumulation. The effect of TNF-α on myo-inositol accumulation was found in large-vessel endotheli

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Basu, Sautrik, Anusuya Basak, Dibyendu Sekhar Mahanty, Sayani Bhattacharjee, and Jukta Adhikari. "Biosynthesis of Myo-Inositol in Chloroplasts of Salinity-Stressed Marine Macro Alga Ulva lactuca." Botanica 25, no. 1 (2019): 32–40. http://dx.doi.org/10.2478/botlit-2019-0004.

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AbstractThe present communication reports enhanced myo-inositol biosynthesis under natural conditions in Ulva lactuca Linn. based on the study conducted on its two prime enzymes [L-myo-inositol-1-phosphate synthase (MIPS) and myo-inositol-1-phosphate phosphatase (MIPP)] involved in myo-inositol biosynthesis. The two key enzymes obtained from chloroplastidial sources were partially purified to about 49- and 58-fold, respectively, over the homogenate following low speed centrifugation, high speed centrifugation, 0–80% ammonium sulphate precipitation and successive chromatography using ion exchan

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Chen, Liangjing, Elias T. Spiliotis, and Mary F. Roberts. "Biosynthesis of Di-myo-Inositol-1,1′-Phosphate, a Novel Osmolyte in Hyperthermophilic Archaea." Journal of Bacteriology 180, no. 15 (1998): 3785–92. http://dx.doi.org/10.1128/jb.180.15.3785-3792.1998.

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ABSTRACT Biosynthesis of di-myo-inositol-1,1′-phosphate (DIP) is proposed to occur with myo-inositol andmyo-inositol 1-phosphate (I-1-P) used as precursors. Activation of the I-1-P with CTP and condensation of the resultant CDP-inositol (CDP-I) with myo-inositol then generates DIP. The sole known biosynthetic pathway of inositol in all organisms is the conversion of d-glucose-6-phosphate tomyo-inositol. This conversion requires two key enzymes:l-I-1-P synthase and I-1-P phosphatase. Enzymatic assays using 31P nuclear magnetic resonance spectroscopy as well as a colorimetric assay for inorganic

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Majumder, Arun Lahiri, Margaret D. Johnson, and Susan A. Henry. "1l-myo-Inositol-1-phosphate synthase." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1348, no. 1-2 (1997): 245–56. http://dx.doi.org/10.1016/s0005-2760(97)00122-7.

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Nakanishi, T., A. Yamauchi, M. Sugita, and Y. Takamitsu. "Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla." Journal of the American Society of Nephrology 7, no. 2 (1996): 283–89. http://dx.doi.org/10.1681/asn.v72283.

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During antidiuresis, renal papillary cells accumulate organic osmolytes preferentially over inorganic ions. It has been previously demonstrated that sodium infusion increased all of these organic osmolytes except myo-inositol (1). Conversely, urea infusion increased only glycerophosphorylcholine significantly. In addition to sodium and urea, potassium localized in tissue and urine influenced the composition of organic osmolytes. The goal of this study was to clarify how the level of mRNA of osmoregulatory protein is regulated by the extracellular solutes and how it affects the accumulation of

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Gee, N. S., C. I. Ragan, K. J. Watling, et al. "The purification and properties of myo-inositol monophosphatase from bovine brain." Biochemical Journal 249, no. 3 (1988): 883–89. http://dx.doi.org/10.1042/bj2490883.

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1. An inositol monophosphatase was purified to homogeneity from bovine brain. 2. The enzyme is a dimer of subunit Mr 29,000. 3. The enzyme hydrolyses both enantiomers of myo-inositol 1-phosphate and both enantiomers of myo-inositol 4-phosphate, but has no activity towards inositol bisphosphates, inositol trisphosphates or inositol 1,3,4,5-tetrakisphosphate. 4. Several non-inositol-containing monophosphates are also substrates. 5. The enzyme requires Mg2+ for activity, and Zn2+ supports activity to a small extent. 6. Other bivalent cations (including Zn2+) are inhibitors, competitive with Mg2+.

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Salamon´zyk, Grzegorz M., and K. Michał Pietrusiewicz. "A practical three-step conversion of myo-inositol into d-myo-inositol 1-phosphate." Tetrahedron Letters 32, no. 32 (1991): 4031–32. http://dx.doi.org/10.1016/0040-4039(91)80619-h.

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Yi, Minghua, Liuzhen Yang, Jian Ma, et al. "Biosynthesis of myo-inositol in Escherichia coli by engineering myo-inositol-1-phosphate pathway." Biochemical Engineering Journal 164 (December 2020): 107792. http://dx.doi.org/10.1016/j.bej.2020.107792.

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Strasser, Heiner, Christina Hoffmann, Hans Grisebach, and Ulrich Matern. "Are Polyphosphoinositides Involved in Signal Transduction of Elicitor-Induced Phytoalexin Synthesis in Cultured Plant Cells ?" Zeitschrift für Naturforschung C 41, no. 7-8 (1986): 717–24. http://dx.doi.org/10.1515/znc-1986-7-810.

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Abstract The phospholipids of cultured parsley and soybean cells were labelled with myo-[2-3H]inositol, [2-3H]glycerol or [32P]orthophosphate. By one-and two-dimensional chromatographic comparison of the labelled phospholipids with reference substances, the presence of 1-(3-sn-phosphatidyl)-ᴅ-myo-inositol 4-phosphate and 1-(3-sn-phosphatidyl)-ᴅ-myo-inositol 4,5-bisphosphate was demonstrated in these cultures. These results were corroborated by analysis of the deacylation products. Cells were labelled with either myo-[2-3H]inositol, [2-3H]glycerol or [32P]orthophosphate and subsequently challen

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Klages, Karin, Helen Donnison, Helen Boldingh, and Elspeth MacRae. "myo-Inositol is the major sugar in Actinidia arguta during early fruit development." Functional Plant Biology 25, no. 1 (1998): 61. http://dx.doi.org/10.1071/pp97052.

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Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq. is a cold tolerant and heavy cropping species from the kiwifruit [Actinidia deliciosa var. deliciosa (A. Chev.) C.F. Liang et A.R.Ferguson] family that has potential for commercialisation. As fruit developed, glucose was the major sugar (74%) in A. deliciosa during the first 40 days after anthesis, whereas myo-inositol was the major sugar (60–65%) in A. arguta.myo-Inositol accumulated rapidly in A. arguta during the first 20–30 daa then more slowly as fruit grew to reach a steady state level, between 15 and 50 mg fruit-1 for different selection

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Nakanishi, T., and M. B. Burg. "Osmoregulatory fluxes of myo-inositol and betaine in renal cells." American Journal of Physiology-Cell Physiology 257, no. 5 (1989): C964—C970. http://dx.doi.org/10.1152/ajpcell.1989.257.5.c964.

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Renal medullary cells contain high concentrations of "compatible" organic osmolytes, such as myo-inositol, betaine, sorbitol, and glycero-phosphorylcholine. These organic osmolytes accumulate as an osmoregulatory response to the high and variable interstitial NaCl concentration that is part of the urinary concentrating mechanism. Madin-Darby canine kidney (MDCK) cells in culture were previously shown to accumulate myo-inositol and betaine in response to increased NaCl. These organic osmolytes are taken up by sodium-dependent active transport into the cells from the medium. The maximum concentr

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Rolnik, Agata, Beata Olas, Joanna Szablińska-Piernik, et al. "Beneficial In Vitro Effects of a Low Myo-Inositol Dose in the Regulation of Vascular Resistance and Protein Peroxidation under Inflammatory Conditions." Nutrients 14, no. 5 (2022): 1118. http://dx.doi.org/10.3390/nu14051118.

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Oxidative stress induces functional changes in arteries. Therefore, the effect of myo-inositol, a possible anti-inflammatory/antioxidant agent was studied on human plasma and rat thoracic arteries. Aortic rings from male Wistar rats (3 months of age) were incubated with myo-inositol (1, 10 and 100 μM, 120 min) and analyzed using the gas chromatography (GC) method. In another experiment, aortic rings were protected first with myo-inositol (1 µM, 60 min) and then subjected to a thromboxane receptor agonist (U-46619, 0.1 nM, 60 min). Therefore, these four groups under the following conditions wer

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Ellingson, David, Ted Pritchard, Pamela Foy, et al. "Analysis of Free and Total Myo-Inositol in Foods, Feeds, and Infant Formula by High-Performance Anion Exchange Chromatography with Pulsed Amperometric Detection, Including a Novel Total Extraction Using Microwave-Assisted Acid Hydrolysis and Enzymatic Treatment." Journal of AOAC INTERNATIONAL 95, no. 5 (2012): 1469–78. http://dx.doi.org/10.5740/jaoacint.12-028.

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Abstract A method for the analysis of free and total myo-inositol in foods, feeds, and infant formulas has been developed and validated using high-performance anion exchange chromatography with pulsed amperometric detection. The option of a free myo-inositol determination or a complete total myo-inositol determination from main bound sources can be achieved. These sources include phytates, lower phosphorylated forms, and phosphatidylinositol. This approach gives the option for subtraction of myo-inositol from nonbioavailable sources when it is quantified using other methods if a total bioavail

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Simmons, D., J. Bomford, and L. L. Ng. "myo-Inositol influx into human leucocytes: methods of measurement and the effect of glucose." Clinical Science 78, no. 3 (1990): 335–41. http://dx.doi.org/10.1042/cs0780335.

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1. Low intracellular concentrations of myo-inositol in diabetic cells may contribute to the development of tissue damage. The cause of these low levels is unknown, but inhibition of a putative myo-inositol transporter by high concentrations of glucose has been proposed. We have developed a triple-isotope method for estimating myo-inositol influx into human leucocytes and so investigated both the kinetics of this uptake in normal volunteers and the effect of glucose upon it. 2. Uptake was composed of a passive component with a rate constant of 2.4 ± 0.3 × 10−2 min−1 and a saturable component wi

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Shears, S. B., D. J. Storey, A. J. Morris, et al. "Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate." Biochemical Journal 242, no. 2 (1987): 393–402. http://dx.doi.org/10.1042/bj2420393.

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We have augmented our previous studies [Storey, Shears, Kirk & Michell (1984) Nature (London) 312, 374-376] on the subcellular location and properties of Ins(1,4,5)P3 (inositol 1,4,5-trisphosphate) phosphatases in rat liver and human erythrocytes. We also investigate Ins(1,3,4)P3 (inositol 1,3,4-trisphosphate) metabolism by rat liver. Membrane-bound and cytosolic Ins(1,4,5)P3 phosphatases both attack the 5-phosphate. The membrane-bound enzyme is located on the inner face of the plasma membrane, and there is little or no activity associated with Golgi apparatus. Cytosolic Ins(1,4,5)P3 5-pho

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ARNER, Ryan J., K. Sandeep PRABHU, Jerry T. THOMPSON, George R. HILDENBRANDT, Andrew D. LIKEN, and C. Channa REDDY. "myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol." Biochemical Journal 360, no. 2 (2001): 313–20. http://dx.doi.org/10.1042/bj3600313.

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myo-Inositol oxygenase (MIOX) catalyses the first committed step in the only pathway of myo-inositol catabolism, which occurs predominantly in the kidney. The enzyme is a non-haem-iron enzyme that catalyses the ring cleavage of myo-inositol with the incorporation of a single atom of oxygen. A full-length cDNA was isolated from a pig kidney library with an open reading frame of 849bp and a corresponding protein subunit molecular mass of 32.7kDa. The cDNA was expressed in a bacterial pET expression system and an active recombinant MIOX was purified from bacterial lysates to electrophoretic homog

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Faraci, W. S., S. H. Zorn, A. V. Bakker, E. Jackson, and K. Pratt. "Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation." Biochemical Journal 291, no. 2 (1993): 369–74. http://dx.doi.org/10.1042/bj2910369.

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Despite limiting side-effects, lithium is the drug of choice for the treatment of bipolar depression. Its action may be due, in part, to its ability to dampen phosphatidylinositol turnover by inhibiting myo-inositol monophosphatase. Beryllium has been identified as a potent inhibitor of partially purified myo-inositol monophosphatase isolated from rat brain (Ki = 150 nM), bovine brain (Ki = 35 nM), and from the human neuroblastoma cell line SK-N-SH (Ki = 85 nM). It is over three orders of magnitude more potent than LiCl (Ki = 0.5-1.2 mM). Kinetic analysis reveals that beryllium is a competitiv

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Bailyes, E. M., M. A. J. Ferguson, C. A. Colaco, and J. P. Luzio. "Inositol is a constituent of detergent-solubilized immunoaffinity-purified rat liver 5′-nucleotidase." Biochemical Journal 265, no. 3 (1990): 907–9. http://dx.doi.org/10.1042/bj2650907.

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myo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5′-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. This provides unequivocal evidence that the ectoenzyme 5′-nucleotidase is attached to liver membranes by a glycosyl-phosphatidylinositol lipid anchor.

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