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Artykuły w czasopismach na temat „Nanocapsules – Toxicologie”

Autor: Grafiati

Data publikacji: 30 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Letícia Cruz, and Leandro Tasso. "Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions." Brazilian Journal of Pharmaceutical Sciences 51, no. 4 (2015): 803–10. http://dx.doi.org/10.1590/s1984-82502015000400006.

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abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentration range of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relative standard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from

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Zielińska, Aleksandra, Filipa Carreiró, Ana M. Oliveira, et al. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology." Molecules 25, no. 16 (2020): 3731. http://dx.doi.org/10.3390/molecules25163731.

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Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the poly

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Charlie-Silva, Ives, Natália Martins Feitosa, Juliana Moreira Mendonça Gomes, et al. "Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish." PLOS ONE 15, no. 9 (2020): e0238823. http://dx.doi.org/10.1371/journal.pone.0238823.

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Bikash Medhi, Bikash Medhi, and Dr Swayamprava Dalai. "Polymeric Nanocapsules in Drug delivery." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 5933–35. http://dx.doi.org/10.37285/ijpsn.2022.15.4.1.

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The ever-increasing accomplishment of Nanotechnology in Science has raised the prospects of improving the properties and usability of an array of substances, minimizing the negative impact on human health as well as the environment. In the context of human health, continuous research is going on to obtain the maximum benefit of a pharmaceutical compound with a minimum dose by improving its delivery to the target site. Nanotechnology plays a key role in drug delivery providing target-oriented better therapeutic efficiency with minimal adverse effects. The widespread application potential of pol

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Bagale, Uday D., Shirish H. Sonawane, Bharat A. Bhanvase, Ravindra D. Kulkarni, and Parag R. Gogate. "Green synthesis of nanocapsules for self-healing anticorrosion coating using ultrasound-assisted approach." Green Processing and Synthesis 7, no. 2 (2018): 147–59. http://dx.doi.org/10.1515/gps-2016-0160.

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Abstract The present work deals with the production of nanocapsules containing a natural corrosion inhibition component. Azadirachta indica was encapsulated in urea-formaldehyde polymeric shell using ultrasound-assisted and conventional approaches of in situ polymerization. Subsequently nanocapsules were incorporated into clear epoxy polyamide to develop the green self-healing corrosion inhibition coating. The actual performance of the coating was evaluated based on the studies involving the repair of the crack of high solid surface coating. Corrosion inhibition of the healed area has been eva

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Bulcão, R. P., F. A. de Freitas, E. Dallegrave, et al. "Acute toxicological evaluation of lipid-core nanocapsules." Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.971.

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Bulcão, R. P., F. A. de Freitas, C. D. G. Venturini, et al. "Subchronic toxicological evaluation of lipid-core nanocapsules." Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.972.

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Mazzarino, Letícia, Ismael Casagrande Bellettini, Edson Minatti, and Elenara Lemos-Senna. "Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 219–26. http://dx.doi.org/10.1590/s1984-82502010000200008.

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A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 µg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 µg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully

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Majda Benabbes, Aicha Fahri, Yassir El alaoui, Naoual Cherkaoui, Abdelkader Laatiris, and Younes Rahali. "Formulation of parenteral nutrition based on argan oil nanocapsule system using d-optimal mixture design." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3857–65. http://dx.doi.org/10.26452/ijrps.v11i3.2567.

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In parenteral nutrition, the lipid emulsions are usually presented separately from other components. The admixture is made just before or during administration because of limited stability. The purpose of the present study is the formulation of lipid nanocapsules (LNC) based on Argan-oil and their introduction into preparations for parenteral nutrition, then the evaluation of their stability. The lipid nanocapsules have been prepared according to the phase inversion temperature method. The experimental design was used to determine the feasibility of LNC with Argan oil (A.O.-LNC), the evaluatio

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Grandhi, Srikar, Moawia Al-Tabakha, and Prameela Rani Avula. "Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine." Advances in Pharmacological and Pharmaceutical Sciences 2023 (November 18, 2023): 1–16. http://dx.doi.org/10.1155/2023/8902963.

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The intention of the current work was to develop and optimize the formulation of biodegradable polymeric nanocapsules for lamivudine (LMV) in order to obtain desired physical characteristics so as to have improved liver targetability. Nanocapsules were prepared in this study as aqueous-core nanocapsules (ACNs) with poly(lactide-co-glycolide) using a modified multiple emulsion technique. LMV was taken as a model drug to investigate the potential of ACNs developed in this work in achieving the liver targetability. Three formulations factors were chosen and 33 factorial design was adopted. The se

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11

Lopes, Leonardo Q. S., Cayane G. Santos, Rodrigo de Almeida Vaucher, et al. "Ecotoxicology of Glycerol Monolaurate nanocapsules." Ecotoxicology and Environmental Safety 139 (May 2017): 73–77. http://dx.doi.org/10.1016/j.ecoenv.2017.01.019.

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de Castro Jorge Silva, Arthur, Mariana Härter Remirão, Caroline Gomes Lucas, et al. "Effects of chitosan-coated lipid-core nanocapsules on bovine sperm cells." Toxicology in Vitro 40 (April 2017): 214–22. http://dx.doi.org/10.1016/j.tiv.2017.01.017.

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Marto, J., P. Pinto, M. Fitas, L. M. Gonçalves, A. J. Almeida, and H. M. Ribeiro. "Safety assessment of starch-based personal care products: Nanocapsules and pickering emulsions." Toxicology and Applied Pharmacology 342 (March 2018): 14–21. http://dx.doi.org/10.1016/j.taap.2018.01.018.

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Kumar, AshwiniG, Amit Bhat, and Shoba Rani. "Preparation and characterization of diltiazem nanocapsules: Influence of various polymers." Asian Journal of Pharmaceutics 4, no. 3 (2010): 224. http://dx.doi.org/10.4103/0973-8398.72123.

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Guterres, Sílvia S., Marta P. Alves, and Adriana R. Pohlmann. "Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications." Drug Target Insights 2 (January 2007): 117739280700200. http://dx.doi.org/10.1177/117739280700200002.

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Fracasso, Rafael, Marília Baierle, Gabriela Goëthel, et al. "Evaluation of potential acute cardiotoxicity of biodegradable nanocapsules in rats by intravenous administration." Toxicology Research 5, no. 1 (2016): 168–79. http://dx.doi.org/10.1039/c5tx00207a.

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Bulcão, Rachel P., Fernando A. Freitas, Cristina G. Venturini та ін. "Acute and Subchronic Toxicity Evaluation of Poly(ɛ-Caprolactone) Lipid-Core Nanocapsules in Rats". Toxicological Sciences 132, № 1 (2012): 162–76. http://dx.doi.org/10.1093/toxsci/kfs334.

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Martins, Isabela, Kátia Cristina Cruz Capel, and Denis Moledo de Souza Abessa. "Adults of Sun Coral Tubastraea coccinea (Lesson 1829) Are Resistant to New Antifouling Biocides." Toxics 12, no. 1 (2024): 44. http://dx.doi.org/10.3390/toxics12010044.

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Biocides used in antifouling (AF) paints, such as 4,5-dichlorine-2-n-octyl-4-isothiazole-3-one (DCOIT), can gradually leach into the environment. Some AF compounds can persist in the marine environment and cause harmful effects to non-target organisms. Nanoengineered materials, such as mesoporous silica nanocapsules (SiNCs) containing AF compounds, have been developed to control their release rate and reduce their toxicity to aquatic organisms. This study aimed to evaluate the acute toxicity of new nanoengineered materials, SiNC-DCOIT and a silver-coated form (SiNC-DCOIT-Ag), as well as the fr

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Yurgel, V., T. Collares, and F. Seixas. "Developments in the use of nanocapsules in oncology." Brazilian Journal of Medical and Biological Research 46, no. 6 (2013): 486–501. http://dx.doi.org/10.1590/1414-431x20132643.

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Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Cristiane de Bona da Silva, Leandro Tasso, and Letícia Cruz. "Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery." Brazilian Journal of Pharmaceutical Sciences 52, no. 4 (2016): 735–40. http://dx.doi.org/10.1590/s1984-82502016000400018.

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Michalec, François-Gaël, Markus Holzner, Anissa Souissi, et al. "Lipid nanocapsules for behavioural testing in aquatic toxicology: Time–response of Eurytemora affinis to environmental concentrations of PAHs and PCB." Aquatic Toxicology 170 (January 2016): 310–22. http://dx.doi.org/10.1016/j.aquatox.2015.08.010.

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Alidee, Tahani, Hoda Habbal, and Francois Karabet. "Chitosan- (Prunus avium) Gum Nanocapsules Loaded with Orange Peel Extract." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, no. 1 (2023): 194–201. http://dx.doi.org/10.31351/vol32iss1pp194-201.

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The orange peel extract (OE) is an additive material that has been used widely as a natural antioxidant source and bioactive compounds in Pharmaceutical and food sector. The poor stability and degradation of this extract were considered problems in the industry. New technologies have been introduced recently to prevent this degradation as encapsulation. In this work, chitosan (CS) and Prunus avium gum (PG) were proposed as promising based materials for encapsulation OE via ionic gelation method. The effect of different ratios of CS: PG and CS: OE on encapsulation efficiency (EE %) and th

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Izaguirry, Aryele Pinto, Natasha Frasson Pavin, Melina Bucco Soares, et al. "Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats." Toxicology Research 5, no. 6 (2016): 1561–72. http://dx.doi.org/10.1039/c6tx00203j.

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Srikar, Grandhi, and Avula Prameela Rani. "Tenofovir Loaded Poly (Lactide-Co-Glycolide) Nanocapsules: Formulation Optimization by Desirability Functions Approach." Indian Journal of Pharmaceutical Education and Research 54, no. 2s (2020): s230—s240. http://dx.doi.org/10.5530/ijper.54.2s.79.

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Brum, Aelson A. S., Médelin M. da Silva, Priscilla P. dos Santos, et al. "The Influence of Heating and Photosensitization on the Stability of Lutein- Loaded Lipid-Core Nanocapsules." Current Bioactive Compounds 16, no. 9 (2020): 1340–45. http://dx.doi.org/10.2174/1573407216666200211094654.

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Background: Despite lutein is unstable in light, heat, and oxygen, it is a good quencher of singlet oxygen. The present study evaluated the stability of lutein (92% of purity) in Lipid-core Nanocapsules (Lutein-LNC) prepared through interfacial deposition of preformed polymer, during photosensitization (5-25°C) and heating (70-90°C). Methods: The Lutein-LNC was characterized and presented a polydispersity index of 0.11, an average diameter of 191 nm (dynamic light scattering), zeta potential of -9.14 mV and entrapment efficiency of 100%. Results and Discussion: During photosensitization and he

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Bulcão, Rachel P., Guilherme B. Bubols, Sabrina N. Nascimento, et al. "Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?" Toxicology Research 4, no. 4 (2015): 994–1005. http://dx.doi.org/10.1039/c5tx00030k.

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Jiang, Xuehong, Shuaishuai Wang, and Hui Chen. "A Novel Fabrication of Dose-Dependent Injectable Curcumin Biocomposite Hydrogel System Anesthetic Delivery Method for Care and Management of Musculoskeletal Pain." Dose-Response 18, no. 3 (2020): 155932582092955. http://dx.doi.org/10.1177/1559325820929555.

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Chronic musculoskeletal pain has biological, psychological, and social components. In this article, we have demonstrated the easily injectable nanocomposite carrier for the treatment of chronic musculoskeletal pain. Briefly, the curcumin (Cur) loaded with lipid nanocapsules (LNCs; Cur@LNCs) using the phase invasion method. The synthesized Cur@LNCs were characterized by using scanning electron microscopy, transmittance electron microscopy, and the size of the fabricated nanoparticles confirmed by dynamic light scattering analysis. The synthesized Cur@LNC injectable hydrogel shows excellent resu

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Giacomeli, Renata, Flavia Elizabete Guerra Teixeira, Felipe Barbosa Carvalho та ін. "Curcumin-loaded poly(ϵ-caprolactone) lipid-core nanocapsules: Evaluation of fetal and maternal toxicity". Food and Chemical Toxicology 144 (жовтень 2020): 111625. http://dx.doi.org/10.1016/j.fct.2020.111625.

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Diyanat, Marjan, Hamid Saeidian, Sara Baziar, and Zohreh Mirjafary. "Preparation and characterization of polycaprolactone nanocapsules containing pretilachlor as a herbicide nanocarrier." Environmental Science and Pollution Research 26, no. 21 (2019): 21579–88. http://dx.doi.org/10.1007/s11356-019-05257-0.

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Rampelotto, Camila Reck, Viviane Gonçalves Pereira, Larissa da Silva Silveira, et al. "Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells." Toxicology in Vitro 78 (February 2022): 105259. http://dx.doi.org/10.1016/j.tiv.2021.105259.

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Remião, Mariana Härter, Caroline Gomes Lucas, William Borges Domingues, et al. "Melatonin delivery by nanocapsules during in vitro bovine oocyte maturation decreased the reactive oxygen species of oocytes and embryos." Reproductive Toxicology 63 (August 2016): 70–81. http://dx.doi.org/10.1016/j.reprotox.2016.05.016.

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Lucas, Caroline Gomes, Mariana Härter Remião, Eliza Rossi Komninou, et al. "Tretinoin-loaded lipid-core nanocapsules decrease reactive oxygen species levels and improve bovine embryonic development during in vitro oocyte maturation." Reproductive Toxicology 58 (December 2015): 131–39. http://dx.doi.org/10.1016/j.reprotox.2015.10.004.

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Leite, Elaine Amaral, Andrea Grabe-Guimarães, Homero Nogueira Guimarães, George Luiz Lins Machado-Coelho, Gillian Barratt, and Vanessa C. F. Mosqueira. "Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices." Life Sciences 80, no. 14 (2007): 1327–34. http://dx.doi.org/10.1016/j.lfs.2006.12.019.

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Erdoğar, Nazlı, Safiye Akkın, Thorbjorn T. Nielsen, et al. "Development of oral aprepitant-loaded chitosan–polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation." Journal of Pharmaceutical Investigation 51, no. 3 (2021): 297–310. http://dx.doi.org/10.1007/s40005-020-00511-x.

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Stecanella, Luciano Aparecido, Stephânia Fleury Taveira, Ricardo Neves Marreto, et al. "Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: in vitro release and cytotoxicity studies." Revista Brasileira de Farmacognosia 23, no. 1 (2013): 153–59. http://dx.doi.org/10.1590/s0102-695x2012005000128.

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Zou, Rui, Junwei Li, Ting Yang, et al. "Biodegradable manganese engineered nanocapsules for tumor-sensitive near-infrared persistent luminescence/magnetic resonance imaging and simultaneous chemotherapy." Theranostics 11, no. 17 (2021): 8448–63. http://dx.doi.org/10.7150/thno.59840.

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Kia, Zahra Abrishami, Seyede Tayebeh Sadati Bizaki, Elham Asaádi Ghareh Tapeh, Shadmehr Mirdar Harijani, Nayyereh Katal, and Roya Gorji Baziary. "Recovering the angiogenic/angiostatic balance in NNK-induced lung carcinoma via 12 weeks of submaximal swimming and Nigella sativa nanocapsule." Toxicology Reports 9 (2022): 1452–60. http://dx.doi.org/10.1016/j.toxrep.2022.06.018.

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Ma, Li, Meng Yu, Yingjian Ma, et al. "Ascendancy of pyraclostrobin nanocapsule formulation against Rhizoctonia solani: From a perspective of fungus." Pesticide Biochemistry and Physiology 197 (December 2023): 105682. http://dx.doi.org/10.1016/j.pestbp.2023.105682.

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Pramudya Wardana, Andika, Nanik Siti Aminah, Alfinda Novi Kristanti, et al. "Gynura procumbens NANOENCAPSULATION: A NOVEL PROMISING APPROACH TO COMBAT DENGUE INFECTION." RASAYAN Journal of Chemistry 16, no. 02 (2023): 0976–083. http://dx.doi.org/10.31788/rjc.2023.1628298.

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Nanoencapsulation of G. procumbens with polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) is intended to increase anti-dengue activity and prevent its bioactive deterioration. The particle size of Ga-NPs was 161.00 ± 2.17 nm with a PDI value of 0.33 ± 0.02 while the particle size of Gp-NPs was 136.33 ± 0.47 nm with a PDI value of 0.34 ± 0.01. Those indicated both Ga-NPs and Gp-NPs had a homogeneous particle size distribution. Moreover, both nanocapsules showed stability at 30-100oC but were less stable at high pH and salt concentrations. Ga-NPs have a %LE (96.236 ± 1.156%) higher than the

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Madan, Jyotsana R., Izharahemad N. Ansari, Kamal Dua, and Rajendra Awasthi. "Formulation and In Vitro Evaluation of Casein Nanoparticles as Carrier for Celecoxib." Advanced Pharmaceutical Bulletin 10, no. 3 (2020): 408–17. http://dx.doi.org/10.34172/apb.2020.049.

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Purpose : The objective of this work was to formulate casein (CAS) nanocarriers for the dissolution enhancement of poorly water soluble drug celecoxib (CLXB). Methods: The CLXB loaded CAS nanocarriers viz., nanoparticles, reassembled CAS micelles and nanocapsules were prepared using sodium caseinate (SOD-CAS) as a carrier to enhance the solubility of CLXB. The prepared formulations were characterized for particle size, polydispersity index, zeta potential, percentage entrapment efficiency, and surface morphology for the selection of best formulation. Fourier transform infrared spectroscopy, di

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Portilla, Silvia, Lucía Fernández, Diana Gutiérrez, Ana Rodríguez, and Pilar García. "Encapsulation of the Antistaphylococcal Endolysin LysRODI in pH-Sensitive Liposomes." Antibiotics 9, no. 5 (2020): 242. http://dx.doi.org/10.3390/antibiotics9050242.

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Phage lysins are promising new therapeutics against multidrug-resistant bacteria. These so-called enzybiotics offer, amongst their most notable advantages, high target specificity and low resistance development. Moreover, there are numerous recent and ongoing studies aimed at demonstrating the efficacy and safety of endolysins in animal models or even in clinical trials. Nonetheless, as is the case for other antimicrobials, it is important to assess potential strategies that may broaden their potential applications or improve their stability. Encapsulation, for instance, has given very good re

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Zhou, Ying, Yuxin Guo, Lufei Chen, et al. "Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy." Theranostics 12, no. 12 (2022): 5488–503. http://dx.doi.org/10.7150/thno.73104.

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El-Gogary, Riham I., Maha Nasr, Laila A. Rahsed, and Mohamed A. Hamzawy. "Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal." Life Sciences 298 (June 2022): 120500. http://dx.doi.org/10.1016/j.lfs.2022.120500.

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Itishom, Reny, Ifan Ali Wafa, David Setyo Budi, and Nando Reza Pratama. "Oral Delivery of Purple Sweet Potato (Ipomoea batatas L.) Extract-Loaded Carboxymethyl Chitosan and Alginate Nanocapsule in Streptozotocininduced Diabetic Mice." Indian Journal of Pharmaceutical Education and Research 55, no. 3 (2021): 709–14. http://dx.doi.org/10.5530/ijper.55.3.143.

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Ghaderpoori, Mansour, Ali Jafari, Efat Nazari, et al. "Preparation and characterization of loaded paraquat- polymeric chitosan/xantan/tripolyphosphate nanocapsules and evaluation for controlled release." Journal of Environmental Health Science and Engineering 18, no. 2 (2020): 1057–66. http://dx.doi.org/10.1007/s40201-020-00527-3.

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Imperlini, Esther, Federica Massaro, and Francesco Buonocore. "Antimicrobial Peptides against Bacterial Pathogens: Innovative Delivery Nanosystems for Pharmaceutical Applications." Antibiotics 12, no. 1 (2023): 184. http://dx.doi.org/10.3390/antibiotics12010184.

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The introduction of antibiotics has revolutionized the treatment and prevention of microbial infections. However, the global spread of pathogens resistant to available antibiotics is a major concern. Recently, the WHO has updated the priority list of multidrug-resistant (MDR) species for which the discovery of new therapeutics is urgently needed. In this scenario, antimicrobial peptides (AMPs) are a new potential alternative to conventional antibiotics, as they show a low risk of developing antimicrobial resistance, thus preventing MDR bacterial infections. However, there are limitations and c

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Mroginski Weber, Douglas, Guilherme Teixeira Voss, Renata Leivas de Oliveira, et al. "Topic application of meloxicam-loaded polymeric nanocapsules as a technological alternative for treatment of the atopic dermatitis in mice." Journal of Applied Biomedicine 16, no. 4 (2018): 337–43. http://dx.doi.org/10.1016/j.jab.2018.03.003.

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Rodrigues Ianiski, Francine, Fernanda D'Avila da Silva, Ethel Antunes Wilhelm, et al. "Enhanced anti-inflammatory benefits of meloxicam-loaded lipid-core nanocapsules in a mouse pleurisy model: A comparative study with a free form drug." Journal of Applied Biomedicine 14, no. 2 (2016): 105–12. http://dx.doi.org/10.1016/j.jab.2015.04.006.

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Huang, Xueping, Aiping Wang, Jian Luo, et al. "Lambda-cyhalothrin-loaded nanocapsules pose an unacceptable acute toxicological risk to zebrafish (Danio rerio) at the adult and larval stages but present an acceptable risk to embryos." Journal of Hazardous Materials 422 (January 2022): 126853. http://dx.doi.org/10.1016/j.jhazmat.2021.126853.

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Guessous, Fadila, Jean-Claude Daran, Bernard Viossat, et al. "Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules." Metal-Based Drugs 5, no. 6 (1998): 337–45. http://dx.doi.org/10.1155/mbd.1998.337.

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Streszczenie:

Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu2(Indo)4(DMF)2 I crystallizes in space group P-1 (a = 10.829(2), b = 13.379(2), c = 16.491(3) Å; α = 105.58(2), β = 101.06(2), γ = 106.96(2)°; V= 2104.6(6) Å3, Z= 1). The title molecule is a centrosymmetric binuclear complex, with Cu atoms bridged by the carboxylate moieties of four indomethacinate ligands. The four nearest O atoms around each Cu atom form a square plan

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