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Rozprawy doktorskie na temat „Natural marine products”

Autor: Grafiati

Data publikacji: 26 października 2024

Data aktualizacji: 31 lipca 2025

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1

Desjardine, Kelsey Lorne. "Bioactive marine natural products." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31286.

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The chemical exploration of extracts from cultures of the marine bacterial isolate PNG-276 yielded the novel antibiotic tauramamide (2.13), a non-ribosomal peptide active against cultures of Enterococcus sp. and methicillin-resistant Staphylococcus aureus (MRSA). A study of extracts of the marine sponge Spirastrella coccinea yielded the novel macrolide methylspirastrellolide C (3.14), which is active against protein phosphatase 2A (PP2A). A third study examined sponge extracts active in a cannabinoid receptor assay, yielding two known compounds, an A- nor -steroid derivative (4.10) and bengami

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Al-Zereini, Wael. "Natural products from marine bacteria." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982197985.

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Reddy, Priyanka, and saipriyanka@gmail com. "Studies in Marine Natural Products." RMIT University. Applied Sciencez, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091023.091658.

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The focus of this thesis was to study the chemotaxonomic relationship of selected southern Australian marine brown algae of the genera Cystophora and Sargassum. Consequently, this resulted in the isolation and structure elucidation of six new terpenoids from two southern Australian marine brown algae Cystophora moniliformis and Sargassum fallax together with 10 previously reported natural products. As a result of the re-isolation of these known secondary metabolites, updated and complete structural characterisation data could be provided for the first time for 7 of these compounds. Chemotax

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Kirkham, James E. D. "Synthesis of marine natural products." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442593.

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Prinsep, Michéle. "Studies in marine natural products." Thesis, University of Canterbury. Chemistry, 1990. http://hdl.handle.net/10092/7256.

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Two new β-carboline alkaloids were isolated from the bryozoan Cribricellina cribraria. One of these, 1-vinyl-8-hydroxy-β-carboline, was the major cytotoxic component of the extract, while the other had a novel sulphone structure. Several other known β-carboline alkaloids were also isolated from the extract. To investigate structure-activity relationships in these compounds, several derivatives of the major alkaloid were prepared and a number of 1-substituted β-carboline alkaloids synthesised. Nmr spectroscopic studies of these compounds were carried out and previously published ¹³C nmr data f

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Stirling, David J. "Studies on marine natural products." Thesis, University of Canterbury. Chemistry, 1996. http://hdl.handle.net/10092/7815.

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An investigation of the marine sponge Halisarca sp. was carried out following the discovery of strong activities in antiviral and P388 murine leukaemia assays of an extract from this sponge. A polyether type of compound is suspected as the cause of this activity. The investigation of Halisarca sp. made a significant contribution to the development of a chemical screening process. The absolute configuration of pateamine has been elucidated by a combination of degradative and synthetic chemistry utilising formation of diastereoisomers with Mosher's acid. Several other derivatives of pateamine a

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Hart, Joanne B. "Studies on marine natural products." Thesis, University of Canterbury. Chemistry, 1995. http://hdl.handle.net/10092/7850.

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The halichondrins are a series of polyether macrolides displaying potent in vitro and in vivo antitumour activities and, as such, represent important leads as anticancer drugs. These compounds had previously been isolated from a number of unrelated marine sponges, such as Lissodendoryx sp., a high yielding deep-water sponge located off the Kaikoura coast of New Zealand. Structure-activity relationships in the halichondrin senes have now been investigated. Hemi-synthetic modifications of selected naturally-occurring halichondrins have produced over fourteen new analogues. The biological activi

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8

Barrow, Colin James. "Studies in marine natural products." Thesis, University of Canterbury. Chemistry, 1988. http://hdl.handle.net/10092/8598.

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The bioactivity directed analysis of the extract from a sponge of the genus Sarcotragus led to the isolation of a series of bioactive sesterterpenes, of which variabilin (1a) was the major component. The sesterterpenes (29a), (30) and (31a), along with the related C₂₁ furanoterpene (32), were present in lesser amounts. The unequivocal assignment of the stereochemistry of the 20,21 double bond in variabilin as 20(Z) was achieved through examination of the22-O-methyl derivative (1b) of variabilin and the isolation of the variabilin isomer (29a) with the 20(E) stereochemistry. Variabilin was als

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9

Bringans, Scott D. "Studies on natural product derivatives : HIV therapies incorporating marine natural products." Thesis, University of Canterbury. Chemistry, 2001. http://hdl.handle.net/10092/6699.

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CV-N is an 11 kDa, anti-HIV protein that binds strongly to the envelope glycoprotein, gp120, expressed on the outer surface of the free virion and also on HIV-infected cells. As such, it represents an important lead for development of anti-HIV therapeutics. Marine toxins such as the halichondrins have potent in vivo cytotoxicities and are lethal to cells. The combination of this potency of the marine toxins with the unique targeting capability of CV-N has been harnessed to produce conjugates that have the potential to selectively target and eliminate HIV-infected cells. Three forms of the pro

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10

Thornhill, Andrew John. "Synthetic studies towards marine natural products." Thesis, Bangor University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364987.

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Rowley, David Chapman. "Antiviral natural products from marine sources /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3035894.

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12

Lorente, Crivillé Adriana. "Marine Natural Products. Synthesis and structure determination." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/279367.

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Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial sources, marine habitat has not been so extensively studied; this field awaited refinements in technologies to collect the source organisms, and development of more advanced analytic techniques to better understand the more complex isolated compounds. Since 1950s this field has suffered an exponential push; considering that water covers around a 70% of the earth’s surface, a

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13

Loosley, Benjamin Charles. "Efforts towards syntheses of marine natural products." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63303.

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This thesis describes work attempting to synthesize and derivatize marine natural products. Chapter 1 outlines a brief history of natural products chemistry. It explains why modern medicines are commonly derived from natural sources using historical examples. It also explains why natural products chemists have turned to organisms in the oceans for exploration into new and unique molecular frameworks and biological activities. Chapter 2 describes the work done towards total synthesis of the marine natural product cladoniamide G. The successful approach involves coupling a halogenated 2,2-bisin

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14

Phipps, Richard K. "Natural products from marine derived micro-organisms." Thesis, University of Canterbury. Chemistry, 2002. http://hdl.handle.net/10092/5796.

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A large number of micro-organisms were cultured from marine substrates collected from multiple sites along the coast of the South Island of New Zealand. Depending on growth rate and colony morphology the micro-organisms were classified as terrestrial, facultative marine or obligate marine. Micro-organisms were selected for large scale culture and extraction based on either apparent unusual morphology or observed cytotoxicity in small scale extracts. Two very pale yellow compounds were isolated from cytotoxic extracts prepared from culture broths of a Fusarium sp. The first compound (A) was id

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15

Lill, Rachel E. "Studies on New Zealand marine natural products." Thesis, University of Canterbury. Chemistry, 1999. http://hdl.handle.net/10092/6078.

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The halichondrins, isolated from the Kaikoura sponge Lissodendoryx sp., are a series of polyether macrolides displaying potent in vivo antitumour activity. As such, they represent important leads as potential anticancer drugs. This research was focused on methodology that would enhance and complement the progress of halichondrins toward clinical trials. A method was established for transforming 53-methoxyneoisohomohalichondrin B, an artefact of the methanol extraction method, to the more useful isohomohalichondrin B. A by-product of this acid treatment was identified as the C38 epimer of isoh

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16

Mokhlesi, Amin [Verfasser]. "Natural Products from Marine Sponges / Amin Mokhlesi." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1154306984/34.

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Ellithey, M. S. (Mona). "Bioactivity of marine organism-derived natural products." Thesis, University of Pretoria, 2013. http://hdl.handle.net/2263/43332.

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Background: HIV/AIDS is one of the most devastating diseases in the world with approximately 36 million people living with the virus in 2012 and approximately 2.7 million new infections in that same year. Antiretroviral therapy (ART) successfully reduce infection and decrease symptoms; but, the emergence of viral drug resistance due to drug induced mutations in viral genes can render treatment ineffective. Infection with HIV not only weakens the immune system leading to AIDS and increasing the risk of opportunistic infections, but also increases the risk of several types of cancer. These

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18

Brastianos, Harry Charilaos. "Bioactive natural products from nature." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/3960.

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Bioassay guided fractionation of a crude extract of the marine sponge Neopetrosia exigua resulted in the first reported isolation of exiguamines A and B. These pyrroloquinone alkaloids have an unprecedented hexacyclic skeleton that has not been previously encountered in natural products. Biological studies have identified exiguamine A as a potent in vitro inhibitor of the enzyme indoleamine-2,3-dioxygenase (IDO). IDO is an enzyme expressed by tumor cells to evade the immune system. Inhibitors against this enzyme may allow the immune system to attack cancer cells, making this enzyme a potential

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19

Gautschi, Jeffrey T. "Marine natural products from sponges and deep water, marine-derived fungi /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2006. http://uclibs.org/PID/11984.

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Hickford, Sarah Jane Herbison. "Studies in the Chemistry of Marine Natural Products." Thesis, University of Canterbury. Chemistry, 2007. http://hdl.handle.net/10092/1429.

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Compounds from the marine environment exhibit a wide variety of biological activities, and thus hold much promise as potential drugs. The halichondrins, isolated from the Kaikoura sponge Lissodendoryx sp. are no exception to this, demonstrating potent anticancer activity. Novel cytotoxic compounds have also been isolated from the Chatham Rise sponge Lamellomorpha strongylata. Knowledge of the cellular origins of such compounds is desirable, in order to establish if the sponge or associated micro-organisms are producing the compounds of interest. Siderophores are also important molecules, w

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21

Stapleton, Bronwin Louise. "Structural studies of bioactive natural products from marine invertebrates /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16452.pdf.

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Pereira, Alban R. "Marine natural products : synthesis and isolation of bioactive analogues." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/7526.

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Tauramamide (2-12), a linear acylpentapeptide recently isolated from cultures of Brevibacillus laterosporus (PNG-276) collected in Papua New Guinea, was synthesized in 9 steps and 29% overall yield. Besides confirming the proposed structure, synthetic (2-12) allowed the antimicrobial assessment of this novel antibiotic. Additionally, a new analogue of the surfactin depsipeptides family named dealkylsurfactin (2-48), was prepared in 10 steps and 14% overall yield. The compound was employed as a biological tool in binding studies between the mitotic regulator isomerase Pinl and the microtubule-a

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23

Daoust, Julie. "Isolation and structure elucidation of bioactive marine natural products." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37536.

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Clionamines A-D (2.6-2.9) are new aminosteroids isolated from South African specimens of the sponge Cliona celata. All four compounds (2.6-2.9) are activators of autophagy in MCF-7 cells. Autophagy is a catabolic process that plays an important role in maintaining cellular homeostasis. Autophagy is also directly involved in the removal of bacterial and viral antigens and in the development of cancerous tumors. The novel sesterterpenoid ansellone A (3.4) was isolated from the nudibranch Cadlina luteomarginata and was later found to have been sequestered by the nudibranch from the sponge Phorbas

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Robinson, Paul A. "Studies towards the synthesis of marine polysulfide natural products." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6379.

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Biologically active compounds isolated from marine sources have had increasing interest in recent years with significant research going into the discovery and isolation of novel marine polysulfide natural products. Varacin, probably the most widely studied marine polysulfide to date was the subject of much debated structure elucidation attempts, and more recently several successful synthetic approaches have been published. The work published aims to increase our understanding of marine polysulfide compounds existence in nature and determine the origins of their biological activity. (+)-Aplidiu

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25

Roberts, Bracken. "Identification of Novel Antimalarial Scaffolds From Marine Natural Products." Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5464.

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Malaria, the disease caused by Plasmodium sp., claims the lives of over 1 million people every year, with Plasmodium falciparum causing the highest morbidity. Rapidly acquiring drug resistance is threatening to exhaust our antimalarial drug arsenal and already requires the utilization of combination drug therapy in most cases. The global need for novel antimalarial chemical scaffolds has never been greater. Screening of natural product libraries is known to have higher hit rates than synthetic chemical libraries. This elevated hit rate is somewhat attributed to the greater biodiversity ava

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Shirley, Harold John. "Synthetic investigations into alotane derived sesterterpenoid marine natural products." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9110.

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Phorbaketal A (I) and phorone A (II) are members of a growing family of biologically active sesterterpenoid natural products, derived from marine sponges. These compounds possess potent biological activities and intriguing molecular architectures, which have inspired efforts towards their total synthesis. Early work in this thesis describes how new methodology is developed aimed at the synthesis of phorbaketal A (I). The synthesis and subsequent treatment of the model hydroxyphenol III with PhI(OAc)2 led to the development of a new method for spiroketal synthesis via cascade oxidative dearomat

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Hooper, Gregory John. "Biologically active natural products from South African marine invertebrates." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1003239.

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This thesis describes the chemical and biological investigation of the extracts of six different marine invertebrate organisms collected along the South African coastline. The work on these extracts has resulted in the isolation and structural elucidation of twenty-one previously undescribed secondary metabolites; The history of marine natural product chemistry in South Africa has not previously been reviewed and so a comprehensive review covering the literature from the 1940's up until the end of 1995 is presented here. The marine ascidian Pseudodistoma species collected in the Tsitsikamma Ma

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Quan-Le, Diana Huynh. "Natural Products as Novel Therapies for Tuberculosis." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18464.

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Tuberculosis (TB) continues to devastate the global population as the leading cause of death from an infectious disease. TB infects over 10 million people annually and is estimated to cost the world’s economy over US$984 billion in healthcare and productivity over the next 15 years. The current TB vaccine is only partially effective in preventing infection and any protection afforded wanes over time as the recipients reach adolescence. Furthermore, current treatment programs for TB are lengthy, complex and problematic with regards to patient non-adherence and drug misuse. As TB is endemic in a

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Ridley, Christian Perry. "Chemical and biological studies of marine natural products and marine invertebrate/bacterial symbiosis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3167855.

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Varnavas, Christalla Zenos. "Synthetic studies directed towards sesquiterpene-phenol natural products." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366319.

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Gil, Escolano Alejandro. "Studies toward the synthesis of marine natural products Phormidolides B-D." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/544128.

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Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact with their biological target and the special and unique conditions present in seas, lakes, oceans and rivers allow the biosynthesis of highly potent compunds. Nowadays, the processes to discover a new drug from MNPs are bio-assay guided, giving more importance to the biological results rather than to the molecular structure. After a molecular entity has shown to be biologicall

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Demerdash, Amr El. "Isolation of Bioactive Marine Natural Products and Bioinspired Synthesis of Fused Guanidinic Tricyclic Analogues." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS088.

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Le travail réalisé dans cette thèse a consisté en deux parties principales; la première partie a été centrée sur l’isolement de métabolites marins bioactifs, en mettant l'accent sur l'utilisation de techniques intégrés et modernes pour l'exploration chimique de deux éponges marines sélectionnées pour leurs activités cytotoxiques et antiinfectieuses. L’inhibition du Quorum Sensing pour explorer les activités antibiofilms a été utilisée. L’étude chimique de la première éponge Monanchora sp., a permis l'isolement et l'identification de vingt-huit composés guanidiniques et polycycliques, dont onze

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Dzeha, Thomas Mwambire. "Cyclodepsipeptides from a Kenyan marine cyanobacterium." Thesis, Rhodes University, 2003. http://hdl.handle.net/10962/d1004961.

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An examination of an organic extract of the cyanobacterium Lyngbya majuscula collected from Wasini Island off the southern Kenyan coast led to the isolation of the known cyclodepsipeptide antanapeptin A (7), recently isolated from a Madagascan collection of L. majuscula, and a new bioactive cyclodepsipeptide, homodolastatin 16 (42). Although L. majuscula is a common, pantropical cyanobacterium this study represents the first investigation of the natural product chemistry of a Kenyan population of L. majuscula. The structures of the two cyclodepsipeptides were determined from 2D NMR and mass sp

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Yan, Luping. "Bioactive marine natural products : analogue synthesis, SAR, and target identification." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50069.

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3,6,7-trihydroxycoumarin C11 (2.14) was first isolated from the green alga Dasycladus vermicularis in 1983. C11 and 3,7,8-trihydroxycoumarin C21 (2.15), alongside their precursors C12 (2.18) and C22 (2.20), were synthesized for a target-based screen for anti-HCV drugs, where ideal hits eliminate fluorescence signals by inhibiting the proteolytic activity of HCV NS3pro/Pep4A against a synthetic peptide “BS-IQFS”. With C12 and C22 serving as negative controls, C11 and C21 inhibited the NS3pro/Pep4A activity in vitro. The IC₅₀’s of C11 and C21 were 3.07 μM and 2.10 μM, respectively. A bioassay-g

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Hellou, Jocelyne. "Studies in Marine Natural Products : Onchidoris bilamellata, Nanaimoal and Capnellene." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25822.

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The following thesis is divided into three chapters. The first describes the isolation and identification of a sphingolipid L from the methanolic skin extract of the British Columbia nudibranch Onchidoris bilamellata. The long chain base has been identified as (E)-l,3-dihydroxy-2-amino-16-methyl-4-octadecene (1̲3) and the fatty acid moiety as palmitic acid (1̲2). This ceramide possesses antibacterial activity towards the microorganisms Bacillus subtilis and Staphylococcus aureus. [formula omitted] The second chapter presents our attempt to synthesize a hypothetical structure of nanaimoal (2

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Kasprzyk, Milena, and milena kasprzyk@freehills com. "Synthetic Studies Towards the Tridachione Family of Marine Natural Products." Flinders University. Chemistry, Physics and Earth Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081107.085933.

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Since the middle of the 20th century, significant interest has evolved from the scientific community towards the polypropionate family of marine natural products. A number of these compounds have been shown to possess significant biological activity, and this property, as well as their structural complexity, has driven numerous efforts towards their synthesis. The first chapter provides an introduction into the world of polypropionates, with a discussion on synthetic studies into a number of members of the tridachiapyrone family. Fundamental synthetic concepts utilised in this thesis towards t

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Sigerson, Ralph Clark. "Formal synthesis of the asbestinin family of marine natural products." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3835/.

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The asbestinins are a sub-class of the ether bridged 2,11-cyclised cembranoid family of marine natural products that have been isolated from octocoral species Briareum Asbestinum. They exhibit high structural complexity and a diverse range of bioactivities that include cytotoxicity against tumour cell lines, potent anti-bacterial properties and antagonism of both histamine and acetylcholine. This report presents the continued efforts in developing an efficient synthetic route to the asbestinins which will be general enough to enable the synthesis of virtually every member of this family of com

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Beukes, Denzil Ronwynne. "Structural and synthetic investigations of South African marine natural products." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1005015.

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A chemical investigation of six different marine invertebrates, collected along the South African coastline, resulted in the isolation and structural elucidation of fifteen previously undescribed secondary metabolites along with seven known compounds. The structures of the new metabolites were determined by a combination of spectroscopic and chemical methods. The endemic false limpet Siphonaria capensis was shown to contain two unusual polypropionate metabolites capensinone (162) and capensifuranone (163) as well as 2,4,6,8-tetramethyl-2-undecenoic acid (164) and the known polypropionates (E)-

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Henderson, James A. "Synthesis of marine natural products: Aburatubolactam A and the halichondrins." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3308674.

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Blackburn, Christine Lynn. "The effects of marine natural products on basic cellular processes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3035897.

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Lerata, Mookho Sylvia. "Discovery of cytotoxic natural products from South African marine sponges." University of the Western Cape, 2018. http://hdl.handle.net/11394/6447.

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Magister Pharmaceuticae - Mpharm<br>Cancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established, however, many of the currently available drugs are associated with undesirable side effects and high toxicity. Furthermore, the development of drug resistant cancers makes the search for anticancer lead compounds a priority. In this study a library of prefractionated marine sponge extracts was established and used to prioritise samples for isolation of bioactive metabolites. From the generated librar

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42

Krzysiak, Amanda J. "The isolation and characterization of natural products from marine plants and microorganisms /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/krzysiaka/amandakrzysiak.pdf.

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Dyson, Bryony Sara. "Determining the structures of halogenated marine natural products by total synthesis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:31737a99-a13c-4110-b36d-1c043b66565b.

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Elatenyne, a brominated C<sub>15</sub> acetogenin isolated from the red Laurencia elata marine algae, was originally assigned a pyranopyran structure. Previous total synthesis of the pyranopyran structure has found this assignment to be incorrect. During this work the revised 2,2’-bifuranyl skeleton of elatenyne was suggested, but this skeleton has 32 possible diastereomers. The most likely diastereomer of elatenyne was predicted using computational <sup>13</sup>C NMR chemical shift calculation in combination with the possible stereochemical outcomes from the proposed biosynthesis. Chapter 1 i

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Lane, Amy L. "Marine natural products as antimicrobial chemical defenses and sources of potential drugs." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26556.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Kubanek, Julia; Committee Member: Fernandez, Facundo M.; Committee Member: Harvey, Stephen C.; Committee Member: Hay, Mark E.; Committee Member: Hud, Nicholas V. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Winter, Jaclyn Marie. "Investigating the biosynthesis of halogenated meroterpenoid natural products from marine actinomycetes." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3397239.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed March 31, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Li, Hang, and n/a. "Chemical investigations of Natural Products from Australian Marine Sponge-Derived Fungi." Griffith University. Eskitis Institute for Cell and Molecular Therapies, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20081103.091038.

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This thesis described the chemical investigations of natural products from Australian marine sponge-derived fungi. Sponge samples were collected from the Great Barrier Reef, Queensland, Australia, by Queensland Museum. The thesis is divided into eight chapters and can be devided into two major parts. The first three chapters comprised the first part of the thesis: Chapter 1 outlined the research background, literature review of marine fungal secondary metabolites; Chapter 2 introduced fungal culture and storage background knowledge, and the list of isolated marine fungal strains. Chapter 3 int

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Boot, Claudia M. "Marine-derived fungi : an effective source of novel bioactive natural products /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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Alvarado, Stephenie M. "Identification of novel antimalarials from marine natural products for lead discovery." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4591.

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An estimated 500 million cases of malaria occur each year. The increasing prevalence of drug resistant strains of Plasmodium in most malaria endemic areas has significantly reduced the efficacy of current antimalarial drugs for prophylaxis and treatment of this disease. Therefore, discovery of new, inexpensive, and effective drugs are urgently needed to combat this disease. Marine biodiversity is an enormous source of novel chemical entities and has been barely investigated for antimalarial drug discovery. In an effort to discover novel therapeutics for malaria, we studied the antimalarial act

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Rapson, Trevor Douglas. "Bioactive 4-methoxypyrrolic natural products from two South African marine invertebrates." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1006766.

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This thesis presents an investigation of the 4-methoxypyrrolic constituents of two South African marine invertebrates, the nudibranch Tambja capensis and the bryozoan Bugula dentata. Three known compounds tambjamine A (7), tambjamine E (13) and the tetrapyrrole (15) were isolated during this investigation. All three compounds were shown to be active against oesophageal cancer in accordance with the general anticancer and immunosuppressive properties observed for 4-methoxypyrrolic natural products. Tambjamine A (7), tambjamine E (13) and the tetrapyrrole (15), together with tambjamine K (21) an

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Young, Ryan Mark. "Synthetic and bioactivity studies of antiplasmodial and antibacterial marine natural products." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1005043.

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This thesis is divided into two parts, assessing marine and synthetic compounds active firstly against Plasmodium falciparum (Chapter 3 and 4) and secondly active against methicillin resistant Staphylococcus aureus (MRSA, Chapter 5). In Chapter 3 the synthesis of nine new tricyclic podocarpanes (3.203-3.207 and 3.209-3.212) from the diterpene (+)-manool is described. Initial SAR study of synthetic podocarpanes concluded that the most active compound was a C-13 phenyl substituted podocarpane (3.204, IC₅₀ 6.6 μM). By preparing analogues with varying halogenated substituents on the phenyl ring (3

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