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Rozprawy doktorskie na temat „Necrosis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Bridges, James. "Necrosis in colorectal cancer /." Leeds : University of Leeds, School of Computer Studies, 2008. http://www.comp.leeds.ac.uk/fyproj/reports/0708/Bridges.pdf.

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Albataineh, Eman Mohammad. "Studies of tumour necrosis factor receptor-1 in tumour necrosis factor receptor associated periodic sysndrome (TRAPS)." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537655.

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Dry, P. R. "Primary bud-axis necrosis of grapevines /." Title page, contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09A/09ad798.pdf.

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Naylor, Michael Stuart. "Tumour necrosis factor and ovarian cancer." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332896.

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Braidwood, Luke Anthony. "Engineering resistance to maize lethal necrosis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/273678.

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Modern agriculture is dependent on both global supply chains and crop monocultures. These features aid the evolution and spread of novel plant pathogens. Limited genetic diversity in commercial crop lines can result in widespread susceptibility to emerging pathogens. Pathogen resistance may be developed through conventional breeding approaches, or a number of transgenic strategies. This thesis focuses on the characterisation of an emerging maize disease, Maize lethal necrosis (MLN), and engineering resistant maize lines using an artificial microRNA (amiRNA) approach. MLN is a synergistic viral

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6

Björnberg, Flemming. "Processing of TNF-receptors to soluble receptor forms in myeloid cells." Lund : Dept. of Hematology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39176479.html.

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Green, Ian R. "Studies on ovine tumour necrosis factor alpha." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/29788.

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Tumour necrosis factor alpha (TNFα), a mediator of inflammatory responses and pathologies of a wide variety of diseases, has been extensively studied in humans and mice. However, little has previously been known about this cytokine in the sheep, a species of value not only to the agricultural industry, but also as a laboratory animal. In this work, the cDNA encoding ovine TNFα has been amplified, cloned, sequenced and used to express recombinant ovine TNFα (rovTNFα). The latter has been partially purified, characterised and used to raise both poly- and mono- clonal antibodies. The sequence of

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8

Stewart, Victoria C. "Human renal lipoxygenases : implications for papillary necrosis." Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU078660.

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The long-term administration or abuse of analgesics and therapeutic doses of non-steroidal anti-inflammatory drugs have been implicated in renal papillary necrosis (RPN). Several drugs implicated in RPN undergo metabolic activation, via prostaglandin synthetase (PGS) and / or lipoxygenase (LO) systems in papilla, forming potentially damaging free radicals, providing an attractive theory to account for the necrosis. This thesis demonstrated interspecies and intrarenal variation in terms of renal PGS and LO activities. PGS was primarily responsible for arachidonic acid (AA)-dependent metabolism

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Schobesberger, Martina. "Oligodendroglial degeneration in distemper : apoptosis or necrosis? /." [S.l.] : [s.n.], 1998. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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10

Jaramillo, Martinez Diana. "Epidemiology and pathogenesis of Nervous Necrosis Virus." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13088.

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Viral Nervous Necrosis (VNN) is a globally distributed disease that affects a large number of finfish species, causing significant economic losses on affected farms. The causative agent is a small single stranded RNA virus called Nervous Necrosis Virus (NNV) from the genus Betanodavirus. NNV is neurotropic; clinical signs involve abnormal behaviour and high mortality associated with histopathological findings of vacuolating necrosis in the central nervous system and retina. In Australia, NNV has been isolated from Australian bass (Macquaria Novemaculeata) and barramundi (Lates calcarifer) popu

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11

Doerge, Thomas A., Deborah Young, and Claire Owen. "Internal Bark Necrosis in Southeastern Arizona Apples." College of Agriculture, University of Arizona (Tucson, AZ), 1990. http://hdl.handle.net/10150/215718.

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12

Moriguti, Eny Kiyomi Uemura. "Efeito da L-alanil-L-glutamina na forma de dipeptídeo e L-glutamina-L-alanina na forma de aminoácido livre na evolução da necrose de lesão por queimaduras em ratos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-10042018-143956/.

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Introdução: A classificação da gravidade da queimadura é determinada a partir da relação entre a superfície corporal queimada (SCQ) e a profundidade da lesão. Os fatores que influenciam a evolução da necrose na zona de estase que circunda a zona de necrose (coagulação) podem estar relacionados com a perfusão, inflamação e estresse oxidativo. No presente estudo avaliamos o efeito da glutamina, pois tem sido demonstrado ter papel importante na prevenção de lesão por isquemia e reperfusão, da inflamação e do estresse oxidativo. Objetivo: avaliar o efeito da glutamina na forma de aminoácido livre

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13

Offei, Samuel K. "Molecular analysis of the tobacco necrosis virus genome." Thesis, Imperial College London, 1995. http://hdl.handle.net/10044/1/11319.

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Johnston, Julie Catherine. "In vitro translation of cucumber necrosis virus RNA." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28969.

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The in vitro translation products directed by cucumber necrosis virus (CNV) RNA were analyzed in both rabbit reticulocyte lysate and wheat germ extract cell-free translation systems. In rabbit reticulocyte lysates, one major protein of ca. 33 Mr was produced. In wheat germ extracts, four proteins of ca. 41, 33, 21 and 20 Mr were produced. Hybrid-arrested translation (HART) studies using synthetic CNV antisense RNA corresponding to the entire CNV genome demonstrated that the four major proteins synthesized from CNV virion RNA in wheat germ extracts are virus-specific translation products. The g

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15

Molloy, Sally Dixon. "A DNA Vaccine Against Infectious Pancreatic Necrosis Virus." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/MolloySD2007.pdf.

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16

Engelberts, Ingeborg. "Tumor necrosis factor during sepsis king of cytokines? /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6955.

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Pérez, Lozano Alba Astril. "PATOGENIA DEL VIRUS DE LA NECROSIS PANCREÁTICA INFECCIOSA." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/95135.

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La presente tesina es una revisión bibliográfica sistemática y exhaustiva de la patogenia del virus de la necrosis pancreática infecciosa, con base en la teoría respuesta – daño; propuesta por Casadevall y Pirofski (2003).<br>RESUMEN El virus de la necrosis pancreática infecciosa (VNPI) es el agente causal de la enfermedad conocida como necrosis pancreática infecciosa (NPI). De manera natural los salmónidos son los peces más susceptibles. El curso agudo de la enfermedad puede provocar una mortalidad hasta del 100% en salmónidos jóvenes. En las truchas, la susceptibilidad a la enfermedad dis

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18

Brodowicz, Gary Ray. "Exercise training, indomethacin, and isoproterenol-induced myocardial necrosis /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487265555440899.

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19

Krugten, Michiel Volkert van. "Tumor necrosis factor gene polymorphisms and rheumatic diseases /." Leiden, 2003. http://catalogue.bnf.fr/ark:/12148/cb40223074h.

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20

Oukacha, Khadija. "Perturbation chimique du transport de Tumor Necrosis Factor." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS067.

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Alors qu'il est essentiel pour lutter contre les agents pathogènes, TNF (Tumor Necrosis factor) secrété́ en excès devient nocif pour l'organisme comme dans le cas de maladies inflammatoires chroniques (polyarthrite rhumatoïde ou maladie de Crohn). Les thérapies actuelles sont basées sur des injections récurrentes d'anti-TNF contre lesquelles 30% des patients développent une résistance. Il existe donc un fort besoin de composés chimiques réduisant la sécrétion de TNF. Nous avons exploité la diversité́ des voies de sécrétion dépendantes de l’appareil de Golgi pour identifier des molécules inhiba

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21

Helliwell, Timothy Richard. "Investigations into skeletal muscle damage and regeneration : a study of lectin-binding structures and desmin in skeletal muscle in vivo and in vitro." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327222.

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22

Vaughan-Scott, Tarquin. "Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease." Diss., University of Pretoria, 2002. http://hdl.handle.net/2263/29287.

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Please read the abstract in the section 00front of this document<br>Canine babesiosis, caused by the tick-borne protozoan Babesia canis rossi, is an economically important and potentially fatal disease of dogs in South Africa. The host's response to many infectious diseases is mediated (at least in part) by intercellular messengers called cytokines. One of the most important cytokines released is tumour necrosis factor (TNF). A study was designed to measure serum concentrations of TNF in dogs naturally infected with canine babesiosis and to relate TNF concentrations to clinical severity,

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23

Ferreira, Juliana. ""Análise da necrose em tecidos normais fotossensibilizados pós terapia fotodinâmica - estudo in vivo"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-17052004-144509/.

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O conceito de PDT é a fotoindução da citotoxicidade das células proliferativas envolvendo um agente fotossensibilizador, uma fonte de luz e oxigênio. Apesar de ser uma terapia eficiente no tratamento de várias neoplasias, a PDT apresenta algumas limitações dentre as quais a não seletividade em células do tecido hepático.O presente trabalho avaliou a correlação entre penetração luminosa e necrose, assim como a extensão da mesma em função da concentração do fotossensibilizador utilizado (Photogem) e de três diferentes doses de energia. A transição do epitélio necrosado e do epitélio sadi

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24

Freitas, Vanessa Santana. "Investigação do efeito citotóxico do extrato metanólico de Bixa orellana L sobre células astrocíticas tumorais e astrócitos in vitro." reponame:Repositório Institucional da FIOCRUZ, 2011. https://www.arca.fiocruz.br/handle/icict/4320.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-09-04T17:32:14Z No. of bitstreams: 1 Vanessa Investigacao do efeito cititóxico....pdf: 1637760 bytes, checksum: 53a0a5f0c495bc04a29d54e8f4415870 (MD5)<br>Made available in DSpace on 2012-09-04T17:32:14Z (GMT). No. of bitstreams: 1 Vanessa Investigacao do efeito cititóxico....pdf: 1637760 bytes, checksum: 53a0a5f0c495bc04a29d54e8f4415870 (MD5) Previous issue date: 2011<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Investigar a capacidade antitumoral do extrato metanólico de

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25

Barbara, Jeffrey A. J. "The mechanism of action of tumour necrosis factor-[alpha] /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phb229.pdf.

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Mahtani, Kamal Ram. "The post-transcriptional regulation of tumour necrosis factor alpha." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271639.

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Rayner, Sandra Anne. "Tumour necrosis factor and gene transfer in corneal transplantation." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248143.

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28

Williams, Llinos. "Expression of tumour necrosis factors during chick lens development." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54869/.

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During development of the lens, epithelial cells at the lens equator begin a differentiation process to become secondary fibre cells. The differentiating cells elongate and migrate towards the centre of the lens where they envelop the older, central fibre cells. Differentiation into fibre cells is accompanied by the breakdown of all organelles, such as the mitochondria. All organelle degradation is completed and denucleation occurs at the border of the organelle free zone (OFZ) which contains the central, terminally differentiated, fibre cells. The differentiation pathway is not well character

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Longin, Ondřej. "Construction of synthetic antibodies against tumour necrosis factor alpha." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/39025/.

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This thesis describes efforts towards size reduction of a human tumour necrosis factor alpha (hTNFα)-targeting monoclonal antibody (mAb) infliximab (Remicade®) by means of construction of medium-sized antibody mimics, denoted as synthetic antibodies. The synthetic antibodies constructed by Cu(I) catalyzed azide-alkyne cycloaddition of complementarity determining region (CDR) mimics onto semi-orthogonally protected CTV scaffold derivatives have less than 4% of the molecular weight of the original monoclonal antibody infliximab (144 kDa). The introductory Chapter 1 describes different approaches

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Borg, Sebastian. "Synthetic bone grafts for treatment of femoral head necrosis." Thesis, Uppsala universitet, Oorganisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314857.

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Necrosis of the femoral head is a relatively common medical condition that radically decrease the quality of life for the patient. Left untreated it could lead to destruction of the hip joint. A common treatment is using bone autografts, also called bone chips. However, in the last decades synthetic bone grafts have become a very interesting alternative. This thesis had two aims; to evaulate how porous hydroxyapatite grafts with varied pore size could be produced by different size of the porogen and to create two-phase cements which would form pores in situ by using a dissolvable phase of calc

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31

González, Aguirre Laura V. "Revascularización en dientes traumatizados, rizogénesis incompleta y necrosis pulpar." Trabajo final de especialización, Universidad Nacional de Cuyo. Facultad de Odontología, 2020. http://bdigital.uncu.edu.ar/15323.

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Necrosis pulpar en niños y adolescentes ya sea por traumatismos o caries puede detener el desarrollo radicular en dientes permanentes jóvenes. El tratamiento endodóntico en estos elementos con rizogénesis incompleta, con pulpa necrótica con o sin lesión periapical supone una serie de cambios en la clínica, ya que en el tratamiento convencional hay riesgos tales como provocar fractura de las paredes dentinarias y extrusión del material de relleno hacia el periápice durante la condensación dentro del canal radicular. Aunque actualmente contamos con técnicas de apexificación que utilizan hidróxid

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Willingham, Stephen B. Ting Jenny P. Y. "Microbial pathogen-induced necrosis mediated by NLRP3 and ASC." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1712.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Genetics & Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.

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Watts, Alan D. "The biological role of transmembrane tumour necrosis factor [alpha]." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27668.

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Tumour necrosis factor (TNF) exists in two physiological forms. One is a soluble polypeptide of 17 kDa, and the other a type II integral membrane protein of 26 kDa designated transmembrane TNF. Soluble TNF is derived from the transmembrane form by proteolytic processing. The soluble TNF molecule exerts potent cytotoxic activity against certain types of cancer cells, and plays a critical role in the functioning of the immune and inflammatory system. The transmembrane TNF molecule shares many of the properties of the soluble form in vitro, but its function in the immune system is not as c

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Valbuena-Gonzalo, Carlos. "Identifying Genetic Causes of Hybrid Necrosis in Arrabidopsis lyrata." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-163444.

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Deleterious gene interactions due to accumulation of individual genetic variations between different lineages are a cause of population diversification by creating reproductive barriers that ultimately lead to differentiation of species. One type of deleterious interactions is called “hybrid necrosis”, in which epistatic interactions between some plant immunity genes (usually very variable) cause autoimmunities that produce a necrotic and dwarf phenotype. Hybrid necrosis has been widely studied in several plant species, such as Arabidopsis thaliana and many gene interactions were found for tha

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Atkinson, Yvelle Hope. "Regulation of neutrophil functions by tumor necrosis factor-alpha /." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09pha878.pdf.

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Langton, Amy Jean. "The role of TRUSS in TNFα-TNFRI signalling : implications for inflammatory lung diseases". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608019.

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Bond, Arden Lenore. "The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-[alpha] /." This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-05042010-020132/.

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Saccon, Cassia Maria Toledo. "Alterações nas vias proteoliticas endogenas causados pela peçonha de Bothrops Jararacussu em musculo esqueletico." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314699.

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Orientadores: Stephen Hyslop, Maria Cristina Cintra Gomes Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T19:23:03Z (GMT). No. of bitstreams: 1 Saccon_CassiaMariaToledo_M.pdf: 7279478 bytes, checksum: eb7fda24e7d486cd0267a344badc1b36 (MD5) Previous issue date: 2008<br>Resumo: O acidente causado por serpentes botrópicas produz intensa hemorragia e mionecrose local, com perda e degradação tecidual. Neste trabalho, investigamos as atividades do proteossomo (via seletiva da degradação protéica), catepsinas (

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Higashi, Rosemeire Rosa. "Estudo da osteonecrose no processo de usinagem da cabeça do fêmur utilizando um dispositivo mecânico de furação." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/18/18146/tde-16122014-173014/.

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A utilização de implantes cirúrgicos para artroplastia de quadril com prótese de recapeamento da cabeça femoral como substituto ósseo é um procedimento que tem sido realizado em 35% dos casos de Osteoartrose nos EUA. Entretanto, o atrito da broca e o aumento da temperatura durante a usinagem da cabeça femoral são responsáveis pelo possível aquecimento do tecido ósseo, podendo provocar a necrose óssea térmica. Neste sentido, o desenvolvimento de novos ferramentais e metodologias para minimizar os danos térmicos do atrito torna-se importante. Diante disso, o presente estudo teve como objetivo ve

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Maioli, Marcos Antonio. "Papel da mitocôndria na citoxicidade induzida pela abamectina em hepatócitos isolados de rato /." Araçatuba, 2012. http://hdl.handle.net/11449/92104.

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Orientador: Fabio Ermínio Mingatto<br>Banca: Cézar Rangel Pestana<br>Banca: Guilherme de Paula Nogueira<br>Resumo: Abamectina (ABA), pertencente à família das avermectinas é utilizada mundialmente como parasiticida, porém a intoxicação por ABA pode prejudicar o funcionamento hepático. Existem substâncias que quando metabolizadas exercem atividade tóxica, afetando a função de importantes organelas como a mitocôndria, responsável por uma variedade de processos bioquímicos, como a produção de ATP e morte celular. O objetivo desse estudo foi caracterizar o mecanismo de toxicidade da ABA em hepatóc

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Dias, Kássia de Carvalho. "Efeito das toxinas microbianas provenientes de biofilme simples ou misto de Staphylococcus aureus e Candida albicans sobre monoculturas ou culturas 3D de células da mucosa oral /." Araraquara, 2016. http://hdl.handle.net/11449/148693.

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Orientador: Carlos Eduardo Vergani<br>Resumo: Esta presente tese foi dividida em quatro estudos que tiveram como objetivos. 1. Validar um protocolo e comparar o efeito dos tampões RPMI/MOPS e RPMI/HEPES no desenvolvimento de biofilmes e na viabilidade celular de queratinócitos (NOK-si e HaCat); 2. Comparar o dano celular e a resposta inflamatória induzidos pelos metabólitos de biofilmes simples e misto de Staphylococcus aureus e Candida albicans; 3. Avaliar o tipo de morte celular (apoptose vs. necrose) e a ativação de caspases relacionadas aos metabólitos desses biofilmes e 4. Caracterizar um

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42

Han, Jiahuai. "Study of the regulation of cachectin/tumor necrosis factor expression." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213139.

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Jersmann, Hubertus Paul Anton. "Bacterial lipopolysaccharide and tumour necrosis factor- alpha synergism in inflammation." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phj56.pdf.

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Bibliography: leaves 152-194. This thesis has contributed to the knowledge of how the bacteriokine-cytokine network operates by demonstrating how two major proinflammatory mediators interact in modulating the inflammatory response. Furthermore the discovery of CD14 expression on endothelial cells not only provides greater insight in the pathogenesis of bacterial infection, sepsis and perhaps atherosclerosis, it is also likely to influence the future development of new treatment strategies for those conditions.

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Hel, Zdenek. "Posttranscriptional regulation of tumor necrosis factor-Ã production in macrophages." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0010/NQ36980.pdf.

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Mustapha, Shareef. "Signaling pathways of tumor necrosis factor Ã in ventricular myocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ41751.pdf.

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Morris, Alison. "The role of tumour necrosis factor alpha (TNFđ) in obesity /." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phm8748.pdf.

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Hel, Zdenĕk. "Posttranscriptional regulation of tumor necrosis factor-a production in macrophages." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34642.

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The production of tumor necrosis factor-alpha (TNF-alpha), a key cytokine regulator of an early immune response and a central mediator of the deleterious effects of systemic inflammatory response syndrome, is regulated at both the transcriptional and posttranscriptional level. The 3' -untranslated region (3'-UTR) of TNF-alpha mRNA contains sequences that confer its translational repression in quiescent cells and are responsible for the induction of TNF-alpha production following macrophage contact with bacterial lipopolysaccharide, live bacteria, or viruses.<br>We demonstrate that two distinct

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Bain, Nicola. "Understanding host-pathogen interactions of infectious pancreatic necrosis virus (IPNV)." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158418.

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Sequencing and phylogenetic analysis was used to characterise a number of Scottish IPNV isolates. The majority of isolates from Scotland were genetically closely related to the Sp strain of IPNV. There appears to be a link between the IPN status of a farm and the presence of IPNV in the environment but this is short lived as IPNV does not typically persist in natural reservoirs at sufficiently high levels to allow re-infection to occur. Real-time PCR was used to study the expression of a subset of immune relevant genes following IPNV challenges by a natural (co-habitation) and unnatural (i.p.)

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Dunlop, J. "Modulation of human neutrophil apoptosis by tumour necrosis factor-alpha." Thesis, University of Edinburgh, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649799.

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Many pro-inflammatory mediators have been demonstrated to inhibit neutrophil apoptosis <I>in vitro</I>, suggesting that such agents act not only in a priming or secretagogue capacity but also increase neutrophil functional longevity by delaying apoptosis. We have examined whether this hypothesis holds true for all neutrophil priming agents, in particular TNFα, a potent neutrophil priming agent which has been variably reported to either induce, delay, or have no effect on the rate of constitutive neutrophil apoptosis. We have shown that following a 20 hr incubation the rate of neutrophil apopto

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Knott, Rachel M. "The persistence of infectious pancreatic necrosis virus in Atlantic salmon." Thesis, University of Aberdeen, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330104.

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The persistence of infectious pancreatic necrosis virus (IPNV) in Atlantic salmon was examined with particular emphasis on the association of IPNV with leucocytes. Atlantic salmon were infected with IPNV via the water and via the feed. Despite relatively low mortalities, a high prevalence of IPNV was demonstrated particularly when the virus was introduced via the water. No virus-specific pathology or reduction in the growth performance of infected populations was evident. The conditions for the stimulation of Atlantic salmon leucocytes with the mitogen, phytohemagglutinin (PHA) were optimised

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