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Artykuły w czasopismach na temat "Neurodegenerative Disease (ND)"

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Goldsteins, Gundars, Vili Hakosalo, Merja Jaronen, Meike Hedwig Keuters, Šárka Lehtonen, and Jari Koistinaho. "CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases." Antioxidants 11, no. 2 (2022): 405. http://dx.doi.org/10.3390/antiox11020405.

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A single paragraph of about 200 words maximum. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, pose a global challenge in the aging population due to the lack of treatments for their cure. Despite various disease-specific clinical symptoms, ND have some fundamental common pathological mechanisms involving oxidative stress and neuroinflammation. The present review focuses on the major causes of central nervous system (CNS) redox homeostasis imbalance comprising mitochondrial dysfunction and endoplasmic reticulum (ER) stress.
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Tringali, Cristina, and Paola Giussani. "Ceramide and Sphingosine-1-Phosphate in Neurodegenerative Disorders and Their Potential Involvement in Therapy." International Journal of Molecular Sciences 23, no. 14 (2022): 7806. http://dx.doi.org/10.3390/ijms23147806.

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Neurodegenerative disorders (ND) are progressive diseases of the nervous system, often without resolutive therapy. They are characterized by a progressive impairment and loss of specific brain regions and neuronal populations. Cellular and animal model studies have identified several molecular mechanisms that play an important role in the pathogenesis of ND. Among them are alterations of lipids, in particular sphingolipids, that play a crucial role in neurodegeneration. Overall, during ND, ceramide-dependent pro-apoptotic signalling is promoted, whereas levels of the neuroprotective spingosine
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Pérez-Hernández, Jesús, Víctor Javier Zaldívar-Machorro, David Villanueva-Porras, Elisa Vega-Ávila, and Anahí Chavarría. "A Potential Alternative against Neurodegenerative Diseases: Phytodrugs." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–19. http://dx.doi.org/10.1155/2016/8378613.

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Neurodegenerative diseases (ND) primarily affect the neurons in the human brain secondary to oxidative stress and neuroinflammation. ND are more common and have a disproportionate impact on countries with longer life expectancies and represent the fourth highest source of overall disease burden in the high-income countries. A large majority of the medicinal plant compounds, such as polyphenols, alkaloids, and terpenes, have therapeutic properties. Polyphenols are the most common active compounds in herbs and vegetables consumed by man. The biological bioactivity of polyphenols against neurodeg
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Chen, Chuanzhe. "AI-Aided Diagnosis For Neurodegenerative Diseases: Prospects And Challenges." Transactions on Materials, Biotechnology and Life Sciences 3 (March 24, 2024): 66–72. http://dx.doi.org/10.62051/72thpj80.

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Neurodegenerative disease (ND) represents a chronic disease characterized by loss of neuron function and death, such as Alzheimer's disease, Parkinson's disease, etc. It’s difficult and complex to diagnose ND, due to the requirement for the synthesis of multiple biomarker data, such as genes, proteins, images, etc. The advent of artificial intelligence (AI) technology, particularly through machine learning (ML) and deep learning (DL) algorithms, introduces novel methodologies and tools for ND diagnosis. These methodologies extract pertinent information and patterns from massive, multidimension
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Nishida, Hana, Akihiro Takamiya, Shun Kudo, et al. "P65: Characteristics of refractory late-life depression in the prodromal phase of neurodegenerative diseases." International Psychogeriatrics 35, S1 (2023): 159–60. http://dx.doi.org/10.1017/s104161022300296x.

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Objective:Depression is common in neurodegenerative diseases, and a psychiatric diagnosis of late-life depression (LLD) may be changed to neurodegenerative disease during the follow-up period. The aim of this study was to identify clinical characteristics of LLD that might be prodromal state of neurodegenerative diseases.Methods:We conducted a retrospective chart review to collect data (registered between April 2012 and September 2022) from individuals who received electroconvulsive therapy (ECT) for their severe depressive episodes due to major depressive disorder (MDD) or bipolar disorder, w
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Meng, Kai, Haocheng Jia, Xiaoqing Hou, et al. "Mitochondrial Dysfunction in Neurodegenerative Diseases: Mechanisms and Corresponding Therapeutic Strategies." Biomedicines 13, no. 2 (2025): 327. https://doi.org/10.3390/biomedicines13020327.

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Neurodegenerative disease (ND) refers to the progressive loss and morphological abnormalities of neurons in the central nervous system (CNS) or peripheral nervous system (PNS). Examples of neurodegenerative diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Recent studies have shown that mitochondria play a broad role in cell signaling, immune response, and metabolic regulation. For example, mitochondrial dysfunction is closely associated with the onset and progression of a variety of diseases, including ND, cardiovascular diseases, di
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Seifan, Alon, Christine A. Ganzer, Krista Ryon, et al. "Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases." Current Aging Science 11, no. 4 (2019): 242–49. http://dx.doi.org/10.2174/1874609812666190204094233.

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Background: Prodromal Neurodegenerative Disease (ND) due to tauopathies such as Alzheimer’s Disease (AD) and Synucleinopathies (SN) such as Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB) present subtly. Although ND are considered cognitive disorders, in fact ND present with behavioral and even medical symptomatology years to decades prior to the onset of cognitive changes. Recognizing prodromal ND syndromes is a public health priority because ND is common, disabling and expensive. Diagnosing prodromal ND in real world clinical settings is challenging because ND of the same pathol
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Sini, Paola, Thi Bang Chau Dang, Milena Fais, et al. "Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons." International Journal of Molecular Sciences 22, no. 16 (2021): 8726. http://dx.doi.org/10.3390/ijms22168726.

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The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions in lifespan, with a larger percentage of members living to an older age, but the ND aetiology and pathogenesis are not fully understood, and effective treatments are still lacking. Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are generally thought to progress as a consequence of genetic susceptibility and environmental influences. Up to now, several environmental triggers have been associated with NDs, and recent studies suggest that some
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Przybyszewski, Andrzej W., Albert Śledzianowski, Artur Chudzik, Stanisław Szlufik, and Dariusz Koziorowski. "Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms." Sensors 23, no. 4 (2023): 2145. http://dx.doi.org/10.3390/s23042145.

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Humans are a vision-dominated species; what we perceive depends on where we look. Therefore, eye movements (EMs) are essential to our interactions with the environment, and experimental findings show EMs are affected in neurodegenerative disorders (ND). This could be a reason for some cognitive and movement disorders in ND. Therefore, we aim to establish whether changes in EM-evoked responses can tell us about the progression of ND, such as Alzheimer’s (AD) and Parkinson’s diseases (PD), in different stages. In the present review, we have analyzed the results of psychological, neurological, an
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Franciotti, Raffaella, Pamela Pignatelli, Claudia Carrarini, et al. "Exploring the Connection between Porphyromonas gingivalis and Neurodegenerative Diseases: A Pilot Quantitative Study on the Bacterium Abundance in Oral Cavity and the Amount of Antibodies in Serum." Biomolecules 11, no. 6 (2021): 845. http://dx.doi.org/10.3390/biom11060845.

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Recent studies support the hypothesis that microbes can seed some Alzheimer’s disease (AD) cases, leading to inflammation and overproduction of amyloid peptides. Porphyromonas gingivalis (Pg) is a keystone pathogen of chronic periodontitis and has been identified as risk factor for the development and progression of AD. The present preliminary study aimed to quantify Pg abundance in neurodegenerative disease (ND) patients compared with neurologic patients without neurodegenerative disorders (no-ND) and healthy controls (HC) to determine possible association between Pg abundance and neurodegene
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Części książek na temat "Neurodegenerative Disease (ND)"

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Gupta, Aradhna, and Bechan Sharma. "Neurodegenerative Diseases (ND)." In Synaptic Plasticity in Neurodegenerative Disorders. CRC Press, 2024. http://dx.doi.org/10.1201/9781003464648-2.

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Ugale, Rajesh R., and Lopmudra Sarode. "Emerging Therapeutic Approaches for Neurodegenerative Diseases." In Neurodegenerative Diseases - Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition). BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040913122010013.

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The most common neurodegenerative diseases (ND) include Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), as well as frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Protein misfolding and aggregation are the key hallmarks of these neurodegenerative diseases, which may lead to cell death, axonal regeneration failure, demyelination, and overall neuronal structural and functional deficits. Usually, ND is diagnosed at a very advanced stage and conventional therapies are directed at treating neurological symptoms but have no effect on disease p
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Kumar, Vijay, Leena Bhardwaj, and Akshara Saxsena. "Neurotrauma and Neurodegenerative Treatment Using Perovskites." In Biomedical Applications of Perovskites: The Era of Bio-Piezoelectric Systems. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815256383124010015.

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Neurodegenerative disease (ND) is a progressive neurological condition that leads to damage to the neuronal connection essential for various sensory, motor and cognitive functions. Neurotrauma (NT) is an external injury to the brain or spinal cord. The incidence and prevalence of ND and NT are alarmingly increasing owing to several factors such as food intake, modern lifestyle, increased life expectancy and several other comorbid conditions. The identification of novel materials that can cross the BBB and delay or deny the onset and progress of neuropathophysiology of ND is essential. Perovski
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Hampel Harald, Toschi Nicola, Babiloni Claudio, et al. "Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology." In Advances in Alzheimer’s Disease. IOS Press, 2018. https://doi.org/10.3233/978-1-61499-876-1-45.

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The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-fr
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Osafo, Newman, David Darko Obiri, Oduro Kofi Yeboah, and Prince Amankwah Baffour Minkah. "Amyotrophic Lateral Sclerosis." In Advances in Medical Diagnosis, Treatment, and Care. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5282-6.ch015.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder (ND) that primarily comprises the neurons responsible for controlling voluntary muscle movement. The unique neuropathologic findings include anterior horn cell degeneration producing muscle atrophy or amyotrophy, degeneration, and sclerosis of the corticospinal tracts. It is a common neuromuscular disease worldwide and has been identified in people of all races. There seems to be neither identified risk factors nor family history associated with most of the documented ALS cases. There exists no treatment for ALS th
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Anand, Abhinav, Neha Sharma, Monica Gulati, and Navneet Khurana. "Amyloid Beta." In Research Anthology on Diagnosing and Treating Neurocognitive Disorders. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3441-0.ch001.

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Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons, which in turn causes a decline in the brain acetylcholine levels. Aβ hypothesis is the most accepted hypothesis pertaining to the pathogenesis of AD. Amyloid Precursor Protein (APP) is constitutively present in brain and it is cleaved by three p
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Anand, Abhinav, Neha Sharma, Monica Gulati, and Navneet Khurana. "Amyloid Beta." In Advances in Medical Diagnosis, Treatment, and Care. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5282-6.ch011.

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Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons, which in turn causes a decline in the brain acetylcholine levels. Aβ hypothesis is the most accepted hypothesis pertaining to the pathogenesis of AD. Amyloid Precursor Protein (APP) is constitutively present in brain and it is cleaved by three p
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Chen, Chia-Chi, Ying-Ching Hung, Chia-Yu Lin, Hsiao-Yun Chen, Ping-Min Huang, and Shao-Wen Hung. "Combined Application Therapies of Stem Cells and Drugs in the Neurological Disorder Attenuation." In Novel Perspectives of Stem Cell Manufacturing and Therapies [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94484.

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Neurological disorders (NDs) are diseases of the central and peripheral nervous system that affected the hundreds of millions of people worldwide. Temporal lobe epilepsy (TLE) is a common NDs with hallucinations and disturbance of consciousness that cause the abnormal neurological activity in any part of brain. Neuroinflammation (NI) has been identified in epilepsy-related tissue from both experimental and clinical evidence and suspected to participate in the formation of neuronal cell death, reactive gliosis and neuroplastic changes in the hippocampus, may contribute to epileptogenesis. The N
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