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Rozprawy doktorskie na temat „Neuroendocrinology”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Ghuman, Sarvpreet Singh. "Neuroendocrinology of stress and reproduction interaction." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403220.

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Claudiano, Gustavo da Silva [UNESP]. "Aspectos da fisiopatologia da sepse em Piaractus mesopotamicus induzida por Aeromonas hydrophila." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/128025.

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Made available in DSpace on 2015-10-06T13:02:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-30. Added 1 bitstream(s) on 2015-10-06T13:19:18Z : No. of bitstreams: 1 000849627.pdf: 553636 bytes, checksum: 5dfc24590b221b9994b1d94923ed02d2 (MD5)<br>A patogenia da sepse envolve múltiplas inter-relações na dinâmica entre os diversos componentes relacionados ao hospedeiro e ao patógeno, com altas taxas de mortalidade em várias espécies animais. Embora seja uma das principais causas de mortalidade de peixes, há escassez de literatura sobre seus fenômenos fisiopatológicos e em seus meca

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Claudiano, Gustavo da Silva. "Aspectos da fisiopatologia da sepse em Piaractus mesopotamicus induzida por Aeromonas hydrophila /." Jaboticabal, 2015. http://hdl.handle.net/11449/128025.

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Orientador: Flávio Ruas de Moraes<br>Coorientador: Julieta Rodini Egracia de Moraes<br>Coorientador: Cleni Mara Marzocchi-Machado<br>Banca: Aureo Evangelista Santana<br>Banca: Rogério Salvador<br>Banca: Luiz Lehmann Coutinho<br>Banca: Antonio Vicente Mundim<br>Resumo: A patogenia da sepse envolve múltiplas inter-relações na dinâmica entre os diversos componentes relacionados ao hospedeiro e ao patógeno, com altas taxas de mortalidade em várias espécies animais. Embora seja uma das principais causas de mortalidade de peixes, há escassez de literatura sobre seus fenômenos fisiopatológicos e em s

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4

Honaramooz, Ali. "Neuroendocrinology of gonadotrophin secretion in prepubertal heifers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ37889.pdf.

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5

Burmeister, Sabrina Suzanne. "Behavioral neuroendocrinology of the green treefrog (Hyla cinerea) /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008291.

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6

Gutzler, Stephanie. "The Neuroendocrinology of Seasonal Aggression in Female Syrian Hamsters." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/61.

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Aggression is a feature of many clinical disorders including autism, Alzheimer’s disease, bipolar disorder, and schizophrenia. The available treatment options act to prevent impulsive aggression through modulation of GABAergic and dopaminergic pathways which come with metabolic and dyskinetic side effects. The mechanism underlying aggressive motivation, however, has not been elucidated. In addition, previous studies have been heavily biased towards males of various species. Mimicking changes in day length, or photoperiod, in the laboratory is a natural manipulation used to examine seasonal cha

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7

Sunnasy, Dharmadeho. "Stress related changes in urinary biogenic amines in humans." Thesis, University of Greenwich, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307885.

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8

Herbison, Allan E. "The medical preoptic gaba system and its role in regulating luteinising hormone secretion." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385415.

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9

Bornstein, Stefan R. "From Neuroendocrinology to Neuroimmunomodulation – A Tribute to Prof. Dr. Samuel McCann." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135755.

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One of the leading experts in the field of Neuroendocrinology and Neuroimmunmodulation, Samuel Mac Donald McCann, known by all his friends as ‘Don’, passed away in 2007. This article pays tribute to his outstanding scientific contribution and a glimpse on his fascinating personality. A member of the National Academy of Sciences of the United States and pioneer in the field of neuroendocrine regulation, he identified numerous hormones and peptides and set the stage for basic concepts in physiology and clinical medicine<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-

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McCann, John Patrick. "Pulmonary neuroendocrinology in health and disease : an immunocytochemical and radioimmunoassay study." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259343.

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11

Bornstein, Stefan R. "From Neuroendocrinology to Neuroimmunomodulation – A Tribute to Prof. Dr. Samuel McCann." Karger, 2007. https://tud.qucosa.de/id/qucosa%3A27673.

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One of the leading experts in the field of Neuroendocrinology and Neuroimmunmodulation, Samuel Mac Donald McCann, known by all his friends as ‘Don’, passed away in 2007. This article pays tribute to his outstanding scientific contribution and a glimpse on his fascinating personality. A member of the National Academy of Sciences of the United States and pioneer in the field of neuroendocrine regulation, he identified numerous hormones and peptides and set the stage for basic concepts in physiology and clinical medicine.<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG

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12

Ferreira, Regis Cavini. "Respostas autonômicas e neuroendócrinas à recuperação de memórias traumáticas." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-17082006-144725/.

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Diversos procedimentos são capazes de induzir a recuperação de memórias traumáticas (RecMem). Técnicas de psicoterapia têm sido usadas para reduzir a resposta emocional às memórias traumáticas, através de processos de re-estruturação e re-significação das vivências, baseados na resiliência dos sujeitos. Durante a RecMem podem ocorrer sinais clínicos de ativação autonômica que não são reações devidas a estressores externos. Pelo contrário, constituem o resultado de estímulos de natureza psíquica gerados internamente. Assim, é possível se especular se eles podem funcionar como estressores purame

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13

Sáenz, de Miera Cristina. "The role of photoperiodic history and internal long-term timing in seasonal neuroendocrinology." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225273.

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Seasonal physiology has evolved as an adaptive strategy to changing environments with daylength (photoperiod) used as the predominant environmental cue to suit breeding and other functions to the external season. However, seasonal physiological state is determined not only by the photoperiod that is currently in effect but also by the animal's history, allowing changes in physiology in anticipation to the seasons. Many mammals and birds show internally timed, long-term (circannual) changes in seasonal physiology, synchronised to the seasons by changing photoperiods. The importance of history-d

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14

O'Brien, John Tiernan. "Magnetic resonance imaging and hypothalmic-pituitary-adrenal axis function in depression and Alzheimer's disease." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308774.

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15

Hassouna, Rim. "Rôles des peptides dérivés de la préproghréline dans le contrôle de la sécrétion de GH et du comportement alimentaire." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00781915.

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Ghréline et obestatine sont deux hormones isolées à partir du tractus gastro-intestinal et issues du clivage protéolytique du même précurseur : la préproghréline. La ghréline est un peptide de 28 acides aminés qui subit une acylation sur sa sérine en position 3 lui permettant de se lier au récepteur des GH sécrétagogues (GHS-R). Ainsi la ghréline stimule la sécrétion de l'hormone de croissance (GH), hormone ayant également un rôle dans la modulation du métabolisme énergétique. En plus de son rôle en faveur de la sécrétion de GH, la ghréline est le seul peptide orexigène du tractus gastro-intes

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16

Vora, Aditya. "Long-term effects of neonatal pain on adulthood stress behavior and neuroendocrinology." Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1329.

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17

Lorenzi, Varenka. "The Behavioral Neuroendocrinology of Fish Sex Change: The Role of Steroids and Monoamines." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/76.

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Social status influences reproductive physiology in many species, and sex change in marine teleost fishes provides an excellent model to understand how an organism can modulate its reproductive system in response to social stimuli. The series of experiments presented in this dissertation has focused on the proximate mechanisms underlying sex change and, in particular, the neuroendocrine factors that might translate social information into physiological changes. The bluebanded goby (Lythrypnus dalli) is a sexually plastic fish, and the dominant female typically changes sex when the male is remo

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18

Bosk, Abigail. "Mating induced fos in forebrain neurons of female mice /." Norton, MA : Wheaton College, 2008. http://hdl.handle.net/10090/6013.

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19

Matthews, Stephen G. "Mechanisms involved in the endocrine response to stress in the sheep." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240089.

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Saelzler, Ursula. "The relationship between basal cortisol levels and cognitive functioning across the adult lifespan." Thesis, Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/55064.

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Age-related declines in cognitive functioning have been well documented, however, there are vast individual differences in the age of onset and magnitude of these changes. This observation has spurred the investigation of the potential risk factors for cognitive decline. Chronic elevations of the steroid hormone cortisol have been shown to compromise hippocampal- and frontal cortex- dependent cognitive tasks in rodents, non-human primates and Cushing’s disease patients. Several studies have extended these findings to investigate possible associations between cortisol and cognition in aging hum

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21

Holtzhausen, Wendy. "Diuretic factors controlling beetle malphighian tubules fluid secretion and immunohistochemistry /." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-07182007-164904.

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22

Júnior, José Donato. "Estudo da ação do núcleo pré-mamilar ventral de ratos no controle reprodutivo e em respostas à exposição feromonal." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-12032009-181647/.

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O objetivo do presente trabalho foi investigar a relação do núcleo pré-mamilar ventral (PMV): 1) na regulação do sistema reprodutivo em fêmeas, 2) como mediador dos efeitos da leptina e 3) na resposta à estimulação feromonal. Para tanto, induzimos lesão bilateral do PMV em ratas. Foi observado que a lesão do PMV promove: alteração no ciclo estral e da histologia ovariana; redução dos níveis de estradiol e LH; e supressão de vias neurais que controlam o eixo reprodutivo. Além disso, a lesão do PMV impediu que a administração central de leptina induzisse secreção de LH durante o jejum. Em outros

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23

Mir, Bonnín Joan Francesc. "Role of carnitine palmitoyltransferase 1A as a downstream effector of ghrelin in cortical neurons and hypothalamus." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398850.

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Previous studies have reported the importance of carnitine palmitoyltransferase (CPT) 1A as an essential part of downstream ghrelin signaling in the central nervous system (CNS) for the control of food intake. Lipid metabolism in the ventromedial hypothalamus (VMH) has emerged as a crucial pathway in the regulation of feeding and energy homeostasis. However, the relationship between changes in CPT1A activity and the intracellular downstream effectors in the VMH that contribute to appetite modulation is not fully understood, nor its possible involvement in central extra-hypothalamic functions o

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24

Spencer, Sarah J. "Stress and the brain : role of the medial prefrontal cortex in regulation of the hypothalamic-pituitary-adrenal axis /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18148.pdf.

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Amstalden, Marcel. "Role of leptin in regulating the bovine hypothalamic-gonadotropic axis." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/507.

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The physiological mechanisms through which nutrition mediates its effects in controlling reproduction are not well characterized. Both neural and endocrine components have been implicated in the communication of nutritional status to the central nervous system. Leptin, a hormone synthesized and secreted mainly by adipocytes, is heavily involved in this communication network. The objectives of studies reported herein were 1) to determine the effects of short-term restriction of nutrients on circulating leptin, leptin gene expression in adipose tissue, and leptin receptor (LR) gene expression

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Branco, Ricardo Garcia. "Stress response in critically ill children." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609718.

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Beck, Meredith Nell. "Effects of Prolactin on the Hypothalamic Pituitary Adrenal Axis in Postpartum Female Rats." Miami University Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303497697.

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Soori, Mehrnoosh. "Neuroendocrine differentiation of prostate cancer cells a survival mechanism during early stages of metastatic colonization of bone /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 105 p, 2009. http://proquest.umi.com/pqdweb?did=1654490661&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Altmieme, Zeinab. "The Role of Nonapeptides in Male Reproduction in Two Cyprinid Species, the Zebrafish (Danio rerio) and the Goldfish (Carassius auratus)." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38911.

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Two distinct nonapeptide systems, consisting of the vasotocin- and oxytocin-related peptides have evolved in vertebrates, and their role in male reproduction is well-described in mammals. In contrast, their comparative role in reproduction in basal vertebrate species, and teleost fishes in particular, has not been investigated in great detail. Using two cyprinid species, the zebrafish (D. rerio) and the goldfish (C. auratus), I address the hypothesis that the teleost nonapeptides vasotocin and isotocin stimulate male cyprinid reproductive physiology by affecting central neuronal and/or periphe

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Saleh, Nadine. "Troubles hormonaux et leur implication dans la progression de la maladie de Huntington." Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0061.

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Les processus physiopathologiques qui mènent à la dégénérescence neuronale ainsi qu’aux symptômes de la maladie de Huntington (MH) demeurent non identifiés et les hypothèses actuelles ne permettent pas d’expliquer l’hétérogénéité intra et interindividuelle de l’évolution de ces symptômes. Ainsi, la progression de la maladie reste donc difficile voire impossible à prédire. Dans ce contexte, il est important d’explorer d’autres facteurs qui semblent être impliqués dans le processus pathogène de la maladie mais qui pourraient également influencer l’évolution de ces symptômes et ainsi prédire la p

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Clarkson, Jenny, and n/a. "Activation of Gonadotropin-releasing hormone neurons by Kisspeptin in the mouse." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081208.114143.

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The gonadotropin-releasing hormone (GnRH) neurons are the final output neurons of a complex neuronal network that controls fertility in all mammals. The GnRH neurons reside in a scattered continuum throughout the anterior hypothalamus. The majority of GnRH neurons project an axon to the median eminence where GnRH is secreted into the hypophyseal-pituitary portal vessels from whence it travels to the anterior pituitary gland. GnRH acts on the gonadotrophs of the anterior pituitary gland to cause the secretion of luteinising hormone (LH) and follicle stimulating hormone (FSH) into the peripheral

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32

Mimouni, Nour El Houda. "Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome (PCOS) in adulthood." Thesis, Lille, 2019. http://www.theses.fr/2019LILUS051.

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Le syndrome des ovaires polykystiques (SOPK) est la principale cause d’infertilité feminine à travers le monde, associé à un risqué élevé de comorbidités avec des conséquences économiques non négligeables. Ce syndrome est caractérisé par une oligo-anovulation, une hyperandrogénie, et un aspect échographique d’ovaires polykystiques. De plus, la plupart des femmes atteintes de SOPK présentent des concentrations élevées de LH suggérant une libération accrue de GnRH. De plus, les patientes SOPK ont habituellement des concentrations en Hormone Anti Müllerienne (AMH) 2 à 3 fois plus élevés que les f

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Mennigen, Jan A. "The Serotonergic System as a Target for Neuroendocrine Disruption in the Brain of Goldfish (Carassius auratus)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19927.

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Serotonin stimulates reproduction and inhibits feeding/growth in the neuroendocrine brain of goldfish. The objective of this thesis is to study the effects of selective serotonin reuptake inhibitor pharmaceuticals (SSRIs) on these systems, as SSRIs, such as fluoxetine, are detected in effluent and bioconcentrate in the brain of wild fish. Genes of the serotonin system were cloned to identify molecular conservation, seasonal expression, and tissue distribution. The serotonin transporter, the target molecule of fluoxetine, was highly conserved and ubiquitously expressed in goldfish. Seasonal cha

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Fletcher, Patrick Allen. "Modeling electrical spiking, bursting and calcium dynamics in gonadotropin releasing hormone (GnRH) secreting neurons." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2574.

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The plasma membrane electrical activities of neurons that secrete gonadotropin releasing hormone (GnRH), referred to as GnRH neurons hereafter, have been studied extensively. A couple of mathematical models have been developed previously to explain different aspects of these activities including spontaneous spiking and responses to stimuli such as current injections, GnRH, thapsigargin (Tg) and apamin. The goal of this paper is to develop one single, minimal model that accounts for the experimental results reproduced by previously existing models and results that were not accounted for by thes

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TAMASHIRO, KELLIE L. K. "CHRONIC SOCIAL STRESS EFFECTS ON ENERGY HOMEOSTASIS: TOWARDS AN ANIMAL MODEL OF THE METABOLIC SYNDROME." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1120014027.

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Medrado, Andreone Teles. "An Atlas of catfish brain - Steindachneridion parahybae (Teleostei: Siluriformes): a detailed cytoarchitectonic study of the different brain areas and nuclei as a basis for further morphological and functional studies." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-04112015-150105/.

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In the present Master\'s Dissertation, a detailed cytoarchtectonic study of the brain of the juvenile catfish - Steindachneridion parahybae, has been performed. The animals used for this Atlas were juvenile specimens of one hundred days post-fertilization. The coronal (transverse) sections (5µm-thick) were obtained by using a rotary microtome, stained with cresyl-violet and examined under a photomicroscopy with the help of a digital system of analysis. Some criteria have been used to classify the different cell masses of the catfish brain: (i) characteristic size, shape and intensity of the st

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Latsko, Maeson Shea. "CORTICOSTERONE TREATMENT PROVIDES PROTECTION INTO ADULTHOOD FROM THE ADVERSE EFFECTS OF ADOLESCENT SOCIAL DEFEAT." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent153251170904353.

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Höglund, Erik. "Neuroendocrinology of agonostic interaction and social signalling in Artic charr (Salvelinus alpinus) : Studies on the neuroendocrine regulation of aggressive behaviour, stress responses and skin colour." Doctoral thesis, Uppsala University, Department of Evolutionary Biology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-616.

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<p>This thesis shows that socially subordinate Arctic charr (<i>Salvelinus alpinus</i>) display elevated brain serotonergic (5-HT) and norepinephric activity along with a chronic activation of the hypothalamic-pituitary-interrenal (HPI) axis, including elevated plasma concentrations of á-MSH. Furthermore, subordinate fish showed an inhibition of aggressive behaviour and darker body coloration, skin darkness being positively correlated with plasma á-MSH. Fish kept on dark background, and thus being darker in body colour, were less aggressive than conspecifics interacting on white background, s

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Höglund, Erik. "Neuroendocrinology of agonistic interaction and social signalling in Arctic charr (Salvelinus alpinus) : studies on the neuroendocrine regulation of aggressive behaviour, stress responses and skin colour /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4964-6/.

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Silva, Renata Juliana da. "Efeitos do treinamento físico intenso e da restrição alimentar sobre a ação da leptina mediada pelo hormônio concentrador de melanina no eixo reprodutor de ratas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-09022012-121522/.

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Avaliamos o efeito do treinamento físico intenso e da restrição alimentar no eixo reprodutor e na expressão do RNAm do MCH em ratas fêmeas. Utilizamos ratas fêmeas sedentárias alimentadas (SA), sedentárias com restrição alimentar, treinadas alimentadas (TA) e treinadas com restrição alimentar. O grupo TR entrou em anestro a partir da quarta semana de experimento. Os grupos restritos apresentaram redução de peso corporal, ovários, úteros e tecido adiposo branco, comparados aos alimentados. Houve redução sérica de leptina nos grupos SR e TR. Os grupos TA, SR e TR apresentaram cistos ovarianos. A

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41

Lee, Yoojin. "Testosterone Reactivity and Neural Activation in the MID task." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1930.

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The purpose of the project was to determine if testosterone reactivity and neural changes could be observed in response to a reward-seeking competitive task, respectively, and whether testosterone was related to neural activation. Forty nine undergraduate students were recruited playing the Monetary Incentive Delay (MID). We found that a subset of participants (N=20) showed testosterone reactivity to the task (ps < .05). During the EEG analyses, cue had a main effect on FRN amplitude in a trend level (p = .084): The large incentive cue triggered smaller (less negative) FRN amplitude than the s

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42

Weil, Zachary M. "Social And Temporal Determinants Of Brain, Behavior And Immune Function." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1219085420.

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Sacchi, Federico. "Glutamatergic Regulation of Adult Goldfish Radial Glial Cells Via Group III Metabotropic Glutamate Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38535.

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Aromatase is an enzyme that converts androgens to estrogens. In teleosts, brain aromatase, also known as aromatase B (cy19a1b), is only expressed in radial glial cells (RGCs). This is in contrast to aromatase A, which is expressed in gonads. Estrogens such as estradiol (E2) modulate neurogenesis in the adult teleost brain. Recent studies show that E2 also differentially regulates aromatase B expression in goldfish RGCs. As a result, teleost RGCs are suggested to be involved in regulating neurogenesis. In addition, aromatase B expression in goldfish RGC is under the control of dopamine suggesti

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Waye, Andrew. "An Investigation of Pulp Mill Effluents and Their Wood Feedstocks as Potential Neuroendocrine Disruptors of the Fish Reproductive Axis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32145.

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Common observations of reduced gonad size and spawning inhibition in wild and laboratory raised fish exposed to pulp mill effluents indicate that reproductive neuroendocrine signalling pathways may be upset. This thesis supported the neuroendocrine disruption of reproduction hypothesis by identifying potential disruptors and targets where these impacts may occur. A mechanistic study of the in vivo fathead minnow (FHM) spawning assay used by industry to assess effluent quality showed that ovulation, but not milt production, was impaired. This finding supported the hypothesis that the neuroendoc

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COTELLESSA, LUDOVICA. "THE INVOLVEMENT OF THE NOTCH PATHWAY IN THE GNRH NEURONS DEVELOPMENT." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/814079.

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The proper development of the hypothalamic-pituitary-gonadal (HPG) axis is essential for normal reproductive competence. Misfunctions in the axis that impairs GnRH synthesis or function result in GnRH deficiency. Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder, with significant heterogeneity of genetic inheritance, that is primarily caused by gonadotropin-releasing hormone (GnRH) deficiency. Clinically, the disorder is characterized by an absence of puberty and infertility. In approximately 50% of cases, CHH patients also suffer from a reduced or

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McClure-Sharp, Jilliane Mary, and mikewood@deakin edu au. "Regulation of corticotropin-releasing factor concentration and overflow in the rat central nervous system." Deakin University. School of Biological and Chemical Sciences, 1998. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20060802.143911.

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Corticotropin-releasing factor (CRF) is the primary hormone of the hypothalamo-pituitary adrenal axis (HPA-axis). In addition to its endocrine function, it has been proposed that CRF acts as a neurotransmitter. The widespread distribution of CRF immunoreactivity and CRF receptors in the rat central nervous system (CNS) supports this theory. Immunohistochemical studies have demonstrated high levels of CRF immunoreactivity the rat hypothalamus, a brain region involved in the regulation and integration of a variety of endocrine and autonomic homeostatic mechanisms. CRF has been shown to be

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Halpern, Bruno. "O papel da melatonina na regulação do tecido adiposo marrom." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-31102018-131724/.

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O tecido adiposo marrom (TAM), caracterizado pela presença da proteína termogênica UCP-1, é conhecido há muitas décadas como um tecido termogênico em mamíferos, porém sua significância clínica em humanos era considerada pequena, com exceção de neonatos, até que o desenvolvimento e uso de métodos de PET-FDG terem demonstrado que humanos adultos também possuem TAM ativo, especialmente após exposição ao frio. Essa descoberta levou a um enorme aumento nas pesquisas sobre o assunto, já que sua ativação, levando a um aumento do gasto energético, poderia, pelo menos na teoria, ser uma possível arma n

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Kaye, Joey Michael. "Mechanisms and clinical implications of the neuroendocrine response to a novel carbon dioxide stressor in man." University of Western Australia. School of Medicine and Pharmacology, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0099.

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Maintenance of normal health requires an intact stress system capable of mounting the metabolic, autonomic, behavioural and motor responses required for coping with or avoiding physiological and pathological challenges. The neuroendocrine component of this response principally involves the hypothalamic-pituitary-adrenal (HPA) and sympatho-adrenomedullary (SAM) axes. Impaired regulation of these axes has been implicated in the pathogenesis and expression of numerous disease states, however, it has proved very difficult to reproducibly activate the HPA and SAM axes and no single test exists that

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Anderson, Greg Muir. "Role of thyroid hormones in the neuroendocrine control of seasonal reproduction in red deer hinds." Lincoln University, 1997. http://hdl.handle.net/10182/2139.

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A series of eight experiments was conducted to investigate the requirement for thyroid hormones in neuroendocrine processes which lead to the seasonally anoestrous state in red deer hinds. The first two experiments used thyroidectomized, ovariectomized, oestradiol-treated hinds which received various thyroid hormone replacement treatments (n=5 per group) to investigate the timing and dose-responsiveness of thyroid hormones in bringing about seasonal oestradiol-induced suppression of plasma LH concentration. A significant seasonal decline in mean plasma LH concentration during September (coinc

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Emmerson, Michael George. "Adolescent stress and social experiences : developmental antecedents of adult behavioural responses to unfamiliar stimuli and the underlying neuroendocrine mechanisms." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12094.

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During adolescence, animals leave the natal home and interact with potentially threatening stimuli (i.e. stressors), e.g. unfamiliar environments and conspecifics. Adolescent stressors can result in fewer interactions with unfamiliar stimuli in adulthood, plausibly due to sustained effects of glucocorticoid exposure on stress physiology (e.g. glucocorticoid secretion and receptor expression). The current thesis tested the hypothesis that adolescent glucocorticoid exposure and social experiences act as stressors by quantifying the effects of the adolescent experiences on behavioural responses t

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