Gotowa bibliografia na temat „Non-pareil Seeds”

Telmisartan is used in the treatment of hypertension. It exhibits poor water solubility. It belongs to class II of Biopharmaceutical Classification system (BCS). It needs enhancement in dissolution and hence bioavailability. The dissolution of drug was improved by coating the drug and carrier over sugar spheres.Size of sugar spheres and concentration of the carrier were two critical variables that were found to affect the dissolution of drug. A 22 factorial design was used to study the effect of concentration of carrier and size of the non-pareil seeds on dissolution. Dissolution of telmisartan was found to increase with increasing concentration of carrier and decreased with respect to size of non-pareil seeds.

Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxypropyl methylcellulose (Surelease®: HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease®/ hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The release of metoprolol succinate from coated pellets was decreased with increased coating load of polymer. The optimized formulation was obtained by 3² full factorial design. The release profile revealed that the optimized formulation follows zero order release kinetics. The stability data showed no interaction for storage at 25ºC and 60% relative humidity.

The present study focuses on the formulation and evaluation of Esomeprazole-coated sustained release pellets using various polymers in different ratios. Esomeprazole, a proton pump inhibitor, is acid-labile and requires protection from gastric acid for effective intestinal absorption. In this research, non-pareil (NP) seeds were prepared using the extrusion-spheronization process and subsequently coated with Esomeprazole and sustained release polymers through the pan coating method. Various polymer ratios were applied to assess their effect on drug release behavior. The formulated pellets were evaluated for physical properties such as size, flow properties, and friability, along with in-vitro drug release studies under simulated gastrointestinal conditions. The influence of different polymer types and coating levels on the drug release profile was systematically analyzed. The optimized formulation exhibited controlled and sustained drug release with improved stability compared to conventional dosage forms.

Pellets were witnessed as one of the promising modified drug delivery systems widely employed now-a-days in the management of various diseases. Mebeverine hydrochloride pellets were coated by suspension layer technique using fluidized bed processor (FBP). This method applied found to be effective to coat the drug uniformly onto the non-pareil (NP) seeds. In this study, three coatings viz., binder (PVP K30), barrier (EC 5 cps) and sustained release (EC 3 cps and HPMC 10 cps) were applied. At each stage of coating, optimized formulation was found out for next subsequent coating and they were F4, B1 and S3. F4 is a formulation with binder solution 2.5% w/v concentration showed 90% coating efficiency with less processing problems and less lump formation. To this formulation barrier coating was given with EC 5 cps. Barrier pellets coated with rate retarding polymers EC 3 cps and HPMC 10 cps. Out of three formulations S3 formulation exhibited 90.39% drug release at 16th hr which matched with the 90.69% release of marketed formulation. Similarity (f2) and dissimilarity (f1) factors for S3 were 83.5 and 6.2 respectively. This revealed the S3 is in vitro bioequivalent with marketed formulation. These pellets were evaluated further for micromeritic properties, SEM and dissolution rate test studies. The micrometrics of S3 revealed good flow ability for packing and filling into capsules (Compressibility index, angle of repose and hausner’s ratio were 24.29%, 26.04° and 1.009 respectively). The formulation was extended for stability studies at different conditions. The stability data produced evidenced the formulation was intact during storage. Key words: pellets, suspension layering technique, rate retarding polymers.

Multi particulate drug delivery system has long run also been made use of to enhance the overall bioavailability going from drugs having low aqueous solubility. Candesartan Cilexetil is an anti-hypertensive drug. Complex and dispersion of Candesartan Cilexetil with the different carriers were prepared to increase its solubility and bioavailability. Due to its low aqueous solubility bioavailability of the drug is 15 % and it shows variable absorption from GIT. Pellets offer several advantages such as proper distribution in the GIT tract, reduces dose dumping, and relief going from administration as well as closing going from chemotherapy therefore within the time being work an immediate-release Pellets of candesartan cilexetil was planned out using the representational of increasing the solubility and in turn bioavailability of Candesartan Cilexetil. Immediate release Pellets containing complex or dispersion of Candesartan Cilexetil with the suitable carrier was prepared using non-pareil sugar seeds. On the non-pareil seeds, drug layering of Candesartan Cilexetil complexed or dispersed with the suitable carrier was done. The formulation having Candesartan Cilexetil and Eudragit dispersed in 1:3 ratios is considered the best product concerning assay and in-vitro drug release. The present top of the line used to be promote withstand constancy written report, the results of and that indicated no important change concerning assay, content uniformity, and in vitro drug release.