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Artykuły w czasopismach na temat „Non-survival scenarios”

Autor: Grafiati

Data publikacji: 8 września 2021

Data aktualizacji: 29 lipca 2025

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Kuijper, Steven, Marieke Pape, Pauline A. J. Vissers, et al. "Survival expressed in best-case, typical and worst-case scenarios for patients with nonmetastatic esophagogastric cancer: A population-based study." Journal of Clinical Oncology 40, no. 4_suppl (2022): 259. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.259.

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259 Background: In recent years new treatment options and the centralization of surgery have improved survival for patients with non-metastatic esophageal and gastric cancer. However, it is currently unknown which patients have mostly benefitted from these treatment advances. The aim of this study was to use population-based data to identify best-case, typical and worst-case scenarios in terms of survival time, and to assess if the survival of these scenarios have changed over time. Methods: Patients diagnosed between 2006-2019 with non-metastatic esophageal (including gastro-esophageal juncti

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Chu, Paula, Miranta Antoniou, Mohit K. Bhutani, Amine Aziez, and Monica Daigl. "Matching-adjusted indirect comparison: entrectinib versus crizotinib in ROS1 fusion-positive non-small cell lung cancer." Journal of Comparative Effectiveness Research 9, no. 12 (2020): 861–76. http://dx.doi.org/10.2217/cer-2020-0063.

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Aim: To perform indirect treatment comparisons of entrectinib versus alternative ROS1 fusion-positive non-small cell lung cancer treatments. Methods: Relevant studies with crizotinib and chemotherapy as comparators of interest identified by systematic literature review were selected for matching-adjusted indirect comparison by feasibility assessment. Matching was based on known prognostic/predictive factors and scenario analyses were used for unreported confounders in comparator trials. Results: Entrectinib yielded significantly better responses versus crizotinib in all scenarios (odds ratio [

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Santiago-Padua, Paola, Jeremy Velázquez-Alvarado, Arelys Del Mar López-Pérez, et al. "Demographic and population response of the threatened coral Acropora cervicornis (Scleractinia, Acroporidae) to fireworm corallivory." Revista de Biología Tropical 71, S1 (2023): 254912. http://dx.doi.org/10.15517/rev.biol.trop..v71is1.54912.

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Introduction: The fireworm Hermodice carunculata is a widespread polychaete that can prey upon many coral species. However, few studies have examined the effect of fireworm predation on coral demographics during non-outbreak periods.  Objective: To determine whether predation by H. carunculata compromised the growth, survival, and population performance of the threatened coral Acropora cervicornis.  Methods: Nursery-reared coral fragments (n = 99) were fixed to the bottom of Punta Melones reef in the Island Municipality of Culebra, Puerto Rico. Predation activity and its demographi

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Yang, Lixia, Karen P. L. Lau, and Linda Truong. "The Survival Effect in Memory: Does It Hold into Old Age and Non-Ancestral Scenarios?" PLoS ONE 9, no. 5 (2014): e95792. http://dx.doi.org/10.1371/journal.pone.0095792.

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Alahmadi, Amani Abdullah, Olayan Albalawi, Rana H. Khashab, et al. "Modeling of lifetime scenarios with non-monotonic failure rates." PLOS ONE 20, no. 1 (2025): e0314237. https://doi.org/10.1371/journal.pone.0314237.

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The Weibull distribution is an important continuous distribution that is cardinal in reliability analysis and lifetime modeling. On the other hand, it has several limitations for practical applications, such as modeling lifetime scenarios with non-monotonic failure rates. However, accurate modeling of non-monotonic failure rates is essential for achieving more accurate predictions, better risk management, and informed decision-making in various domains where reliability and longevity are critical factors. For this reason, we introduce a new three parameter lifetime distribution—the Modified Ki

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Vickers, Adrian. "An Evaluation of Survival Curve Extrapolation Techniques Using Long-Term Observational Cancer Data." Medical Decision Making 39, no. 8 (2019): 926–38. http://dx.doi.org/10.1177/0272989x19875950.

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Objectives. Uncertainty in survival prediction beyond trial follow-up is highly influential in cost-effectiveness analyses of oncology products. This research provides an empirical evaluation of the accuracy of alternative methods and recommendations for their implementation. Methods. Mature (15-year) survival data were reconstructed from a published database study for “no treatment,” radiotherapy, surgery plus radiotherapy, and surgery in early stage non–small cell lung cancer in an elderly patient population. Censored data sets were created from these data to simulate immature trial data (fo

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Correa, Amanda Ribeiro, Ana Mayra Pereira da Silva, Carita Rodrigues de Aquino Arantes, Sebastião Carneiro Guimarães, Elisangela Clarete Camili, and Maria de Fátima Barbosa Coelho. "Quantifying seed germination based on thermal models to predict global climate change impacts on Cerrado species." Seed Science Research 31, no. 2 (2021): 126–35. http://dx.doi.org/10.1017/s0960258521000131.

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AbstractSeed germination is regulated by temperature and can thus be quantified by thermal models, which can predict germination occurrence in biomes and plant survival under possible climate change scenarios. The objective of this study was to quantify germination based on thermal time and survival risk of 14 species in the Brazilian Cerrado in scenarios of future climate change. Seeds were collected in the warmer regions of the Cerrado, central Brazil, placed in incubators to germinate at constant temperatures of 10–50°C and evaluated every hour or day. Germination rate (R50), time for germi

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Inam Ur Rahman*, Nasir Ali, Abid Hussain, and Mehvish Raja. "A Comparative Study Among Parametric, Semiparametric and Non-parametric Techniques Using Survival Data." Review Journal of Social Psychology & Social Works 3, no. 1 (2025): 943–54. https://doi.org/10.71145/rjsp.v3i1.164.

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This study offers a comparative analysis of parametric, semi-parametric, and non-parametric techniques of survival data analysis. It focuses on assessing the methods in terms of their efficiency in estimating survival probabilities and hazard functions. Alternate real and simulated datasets are then utilized to assess the relative strengths and weaknesses of different approaches with respect to efficiency, flexibility, and interpretability. The results indicate that the choice of technique is a factor of the underlying data characteristics, with parametric models working quite well under speci

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Radny, Janina, and Katrin M. Meyer. "The role of biotic factors during plant establishment in novel communities assessed with an agent-based simulation model." PeerJ 6 (August 8, 2018): e5342. http://dx.doi.org/10.7717/peerj.5342.

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Background Establishment success of non-native species is not only influenced by environmental conditions, but also by interactions with local competitors and enemies. The magnitude of these biotic interactions is mediated by species traits that reflect competitive strength or defence mechanisms. Our aim was to investigate the importance of species traits for successful establishment of non-native species in a native community exhibiting biotic resistance in the form of competition and herbivory. Methods We developed a trait-based, individual-based simulation model tracking the survival of non

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Kravchenko, D. N., A. A. Parokonnaya, M. I. Nechushkin, and D. E. Avtomonov. "SPECIAL APPROACHES TO BREAST CANCER HORMONAL THERAPY OF YOUNG PATIENTS." Journal of Clinical Practice 7, no. 2 (2016): 15–20. http://dx.doi.org/10.17816/clinpract7215-20.

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Breast cancer is the most prevalent female malignancy. When diagnosed at young age (up to 40 years), negative clinical, morphological and prognostic features are noted. A non-randomized retrospective trial (n=500) was performed to evaluate different scenarios of breast cancer hormone therapy in young patients. Ovarian suppression in young patients is shown to statistically improve prognosis. Disease-free survival rate values are observed to decrease in patients without ovarian suppression in comparison with any type of ovarian suppression, especially at a remote follow-up (after 60 months). Me

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Tognela, Annette, David Espinoza, Andrew Davidson, et al. "Oncologists' estimates of expected survival time and scenarios for survival: accuracy in the ALTG NITRO trial of 1st line chemotherapy for advanced non–small-cell lung cancer." Journal of Clinical Oncology 34, no. 15_suppl (2016): 9074. http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9074.

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Caldwell, Jillian S., Xingxing S. Cheng, Glenn M. Chertow, and Jeremy D. Goldhaber-Fiebert. "Kidney Transplant Wait Times Under Waiting List Expansion Scenarios." JAMA Network Open 8, no. 3 (2025): e251665. https://doi.org/10.1001/jamanetworkopen.2025.1665.

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ImportanceKidney transplantation offers survival benefits and superior quality of life compared with maintenance dialysis for patients with end-stage kidney disease (ESKD), but it is limited to approximately 25 000 patients annually in the United States. Expanding access to transplant could be accomplished by allowing more patients to join the waiting list or by increasing organ supply.ObjectiveTo estimate how these interventions could affect transplant wait times.Design, Setting, and ParticipantsThis decision-analytic study used a Markov model with a simulated cohort of transplant-eligible US

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Berg, Elena C., Martin I. Lind, Shannon Monahan, Sophie Bricout, and Alexei A. Maklakov. "Kin but less than kind: within-group male relatedness does not increase female fitness in seed beetles." Proceedings of the Royal Society B: Biological Sciences 286, no. 1910 (2019): 20191664. http://dx.doi.org/10.1098/rspb.2019.1664.

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Theory maintains within-group male relatedness can mediate sexual conflict by reducing male–male competition and collateral harm to females. We tested whether male relatedness can lessen female harm in the seed beetle Callosobruchus maculatus . Male relatedness did not influence female lifetime reproductive success or individual fitness across two different ecologically relevant scenarios of mating competition. However, male relatedness marginally improved female survival. Because male relatedness improved female survival in late life when C. maculatus females are no longer producing offspring

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Kesov, George, and Nina Stoyanova. "Abdominal Injuries: A Comprehensive Guide for Non-Medical Professionals." International Journal of Medical Reviews and Case Reports 9, no. 1 (2025): 4. https://doi.org/10.5455/ijmrcr.172-1742201614.

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Abdominal injuries can be life-threatening due to potential internal bleeding, organ damage, and infection. This guideline provides non-medical professionals with clear, evidence-based instructions for recognizing, assessing, and managing both blunt and penetrating abdominal trauma. The recommendations emphasize early symptom recognition, hemorrhage control, patient stabilization, and rapid evacuation to definitive care. Developed with input from trauma surgeons, emergency care specialists, and first-aid trainers, this guide ensures practical application in emergency settings where immediate m

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Muntsant, Aida, Francesc Jiménez-Altayó, Lidia Puertas-Umbert, Elena Jiménez-Xarrie, Elisabet Vila, and Lydia Giménez-Llort. "Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging." Biomedicines 9, no. 2 (2021): 111. http://dx.doi.org/10.3390/biomedicines9020111.

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Life expectancy decreases with aging, with cardiovascular, mental health, and neurodegenerative disorders strongly contributing to the total disability-adjusted life years. Interestingly, the morbidity/mortality paradox points to females having a worse healthy life expectancy. Since bidirectional interactions between cardiovascular and Alzheimer’s diseases (AD) have been reported, the study of this emerging field is promising. In the present work, we further explored the cardiovascular–brain interactions in mice survivors of two cohorts of non-transgenic and 3xTg-AD mice, including both sexes,

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AlShamsi, Abdullatif, Jihad Mohaidat, Noura Al Hinai, and Ahmed Samy. "Instructional and Business Continuity Amid and Beyond COVID-19 Outbreak: A Case Study from the Higher Colleges of Technology." International Journal of Higher Education 9, no. 6 (2020): 118. http://dx.doi.org/10.5430/ijhe.v9n6p118.

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With the announcement of COVID-19 as pandemic, and the call for social distancing, academic institutions reacted by shutting campuses and calling for the shift to virtual online delivery. In HCT, we conducted this study in an effort to sustain success in these global challenging times of crisis that is informed by strategic foresight.HCT called for an all-online delivery starting March 22, 2020 after a two-day pilot in the preceding week. HCT readiness is a result of orchestrating: an ecosystem perspective on digital transformation, a forth-looking institutional strategy that has technology ut

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Guilder, James, Gordon H. Copp, Mark A. Thrush, et al. "Threats to UK freshwaters under climate change: Commonly traded aquatic ornamental species and their potential pathogens and parasites." NeoBiota 76 (October 3, 2022): 73–108. http://dx.doi.org/10.3897/neobiota.76.80215.

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The aquatic ornamental industry, whilst providing socio-economic benefits, is a known introduction pathway for non-native species, which if invasive, can cause direct impacts to native species and ecosystems and also drive disease emergence by extending the geographic range of associated parasites and pathogens and by facilitating host-switching, spillover and spill-back. Although current UK temperatures are typically below those necessary for the survival and establishment of commonly-traded tropical, and some sub-tropical, non-native ornamental species, the higher water temperatures predicte

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Guilder, James, Gordon H. Copp, Mark A. Thrush, et al. "Threats to UK freshwaters under climate change: Commonly traded aquatic ornamental species and their potential pathogens and parasites." NeoBiota 76 (October 3, 2022): 73–108. https://doi.org/10.3897/neobiota.76.80215.

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The aquatic ornamental industry, whilst providing socio-economic benefits, is a known introduction pathway for non-native species, which if invasive, can cause direct impacts to native species and ecosystems and also drive disease emergence by extending the geographic range of associated parasites and pathogens and by facilitating host-switching, spillover and spill-back. Although current UK temperatures are typically below those necessary for the survival and establishment of commonly-traded tropical, and some sub-tropical, non-native ornamental species, the higher water temperatures predicte

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Yan, Jingjing, Gengen He, Anahid Basiri, Craig Hancock, and Siegfried K. Yeboah. "The Impact of Postures and Moving Directions in Fire Evacuation in a Low-Visibility Environment." Sensors 24, no. 5 (2024): 1378. http://dx.doi.org/10.3390/s24051378.

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Walking speed is a significant aspect of evacuation efficiency, and this speed varies during fire emergencies due to individual physical abilities. However, in evacuations, it is not always possible to keep an upright posture, hence atypical postures, such as stoop walking or crawling, may be required for survival. In this study, a novel 3D passive vision-aided inertial system (3D PVINS) for indoor positioning was used to track the movement of 20 volunteers during an evacuation in a low visibility environment. Participants’ walking speeds using trunk flexion, trunk–knee flexion, and upright po

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Belguerna, Abderrahmane, Hamza Daoudi, Khadidja Abdelhak, Boubaker Mechab, Zouaoui Chikr Elmezouar, and Fatimah Alshahrani. "A Comprehensive Analysis of MSE in Estimating Conditional Hazard Functions: A Local Linear, Single Index Approach for MAR Scenarios." Mathematics 12, no. 3 (2024): 495. http://dx.doi.org/10.3390/math12030495.

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In unveiling the non-parametric estimation of the conditional hazard function through the local linear method, our study yields key insights into the method’s behavior. We present rigorous analyses demonstrating the mean square convergence of the estimator, subject to specific conditions, within the realm of independent observations with missing data. Furthermore, our contributions extend to the derivation of expressions detailing both bias and variance of the estimator. Emphasizing the practical implications, we underscore the applicability of two distinct models discussed in this paper for s

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Chakraborty, Aditya, and Mohan D. Pant. "Machine Learning Models for Pancreatic Cancer Survival Prediction: A Multi-Model Analysis Across Stages and Treatments Using the Surveillance, Epidemiology, and End Results (SEER) Database." Journal of Clinical Medicine 14, no. 13 (2025): 4686. https://doi.org/10.3390/jcm14134686.

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Background: Pancreatic cancer is among the most lethal malignancies, with poor prognosis and limited survival despite treatment advances. Accurate survival modeling is critical for prognostication and clinical decision-making. This study had three primary aims: (1) to determine the best-fitting survival distribution among patients diagnosed and deceased from pancreatic cancer across stages and treatment types; (2) to construct and compare predictive risk classification models; and (3) to evaluate survival probabilities using parametric, semi-parametric, non-parametric, machine learning, and de

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Adhikari, Umesh, Elaheh Esfahanian, Jade Mitchell, Duane Charbonneau, Xiangyu Song, and Yang Lu. "Quantitation of Risk Reduction of E. coli Transmission after Using Antimicrobial Hand Soap." Pathogens 9, no. 10 (2020): 778. http://dx.doi.org/10.3390/pathogens9100778.

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Handwashing with soap is an effective and economical means to reduce the likelihood of Escherichia coli infection from indirect contact with contaminated surfaces during food preparation. The purpose of this study was to conduct a quantitative microbial risk assessment (QMRA) to evaluate the risk of infection from indirect contact with fomites contaminated with E. coli after hand washing with antimicrobial hand soaps. A Monte Carlo simulation was done with a total of 10,000 simulations to compare the effectiveness of two antimicrobial and one control (non-antimicrobial) bar soaps in reducing t

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Silverstein, Marc D., and David J. Ballard. "Expert Panel Assessment of Appropriateness of Abdominal Aortic Aneurysm Surgery: Global Judgement versus Probability Estimation." Journal of Health Services Research & Policy 3, no. 3 (1998): 134–40. http://dx.doi.org/10.1177/135581969800300303.

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Objective: To compare an expert panel's global assessment of appropriateness of elective surgery for abdominal aortic aneurysms (AAA) with their assessment of the effect of surgery on the probability of 5-year mortality. Methods: Nine expert panel members rated the appropriateness of 120 scenarios for elective AAA repair on a nine-point scale, and also estimated the 5-year probability of AAA-related death and of non-AAA related death among 30-day survivors of AAA surgery and among patients with unoperated AAA. These probabilities were used to determine differences in 5-year probability of mort

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Foran, James M., Michael G. Heckman, Michael E. Williams, Joanne Willey, and Mark R. Green. "Treatment of Higher-Risk Myelodysplastic Syndrome (MDS) by American Hematology-Oncology Providers (AHOP's): Changes in 1st-Line Treatment Preferences Over Time in Relation to Cytogenetics & Survival Data From Randomized Studies (2006–2010),." Blood 118, no. 21 (2011): 3816. http://dx.doi.org/10.1182/blood.v118.21.3816.3816.

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Abstract Abstract 3816 Background: The hypomethylating agent (HMA) azacitidine (AZA) significantly improves survival compared to conventional care regimens for patients (pts) with “higher risk” MDS (including both Int-2 & High-Risk according to IPSS) (Lancet Oncol 10:223, 2009 – first presented Dec 2007); a more recent trial of the HMA decitabine (DEC) vs. best supportive care in pts with similar IPSS failed to show a significant survival advantage (JCO 29:1987, 2011 – first presented Dec 2008). Since 2006 the immunomodulatory drug lenalidomide (LEN) has been FDA-approved for treatment of

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Liu, Qiantong, Yunnong Peng, Ziyuan Shu, Yuqi Xie, and Ruobin Zhao. "Female Non-Resistance to Sexual Harassment -- An Evolutionary Psychology Perspective." Communications in Humanities Research 31, no. 1 (2024): 85–91. http://dx.doi.org/10.54254/2753-7064/31/20231922.

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Sexual harassment is a pervasive problem that affects individuals in a variety of social contexts, especially in the workplace and public spaces. Researcher has examined the complex phenomenon of women's non-resistance to sexual harassment and explore in depth the psychological, sociocultural and reproductive factors that lead women to not actively oppose or confront sexual harassment. Drawing on both evolutionary and survival perspectives, the paper explores the complex interplay between reproductive strategies, survival motivations, and social norms. Through the survey-based approach, we qua

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Enserro, Danielle M., and Austin Miller. "Improving the Estimation of Prediction Increment Measures in Logistic and Survival Analysis." Cancers 17, no. 8 (2025): 1259. https://doi.org/10.3390/cancers17081259.

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Background/Objectives: Proper confidence interval estimation of the area under the receiver operating characteristic curve (AUC), the net reclassification index (NRI), and the integrated discrimination improvement (IDI) is an area of ongoing research. The most common confidence interval estimation methods employ asymptotic theory. However, developments demonstrate that degeneration of the normal distribution assumption under the null hypothesis exists for measures such as the change in AUC (ΔAUC) and IDI, and confidence intervals estimated under the normal distribution assumption may be invali

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Lang, Pencilla, Daniel R. Gomez, and David A. Palma. "Local Ablative Therapies in Oligometastatic NSCLC: New Data and New Directions." Seminars in Respiratory and Critical Care Medicine 41, no. 03 (2020): 369–76. http://dx.doi.org/10.1055/s-0039-3400290.

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AbstractThe oligometastatic and oligoprogressive disease states have been recently recognized as common clinical scenarios in the management of non-small cell lung cancer (NSCLC). As a result, there has been increasing interest in treating these patients with locally ablative therapies including surgery, conventionally fractionated radiotherapy, stereotactic ablative radiotherapy, and radiofrequency ablation. This article provides an overview of oligometastatic and oligoprogressive disease in the setting of NSCLC and reviews the evidence supporting ablative treatment. Phase II randomized contr

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Sultana, Tabasam, and Muhammad Aslam. "A 3-component mixture of inverse Rayleigh distributions: properties and estimation in Bayesian framework." International Journal of Basic and Applied Sciences 5, no. 2 (2016): 120. http://dx.doi.org/10.14419/ijbas.v5i2.5935.

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<p>This paper is about studying a 3-component mixture of the inverse Rayleigh distributions under Bayesian perspective. The censored sampling scheme is considered due to its popularity in reliability theory and survival analysis. The expressions for the Bayes estimators and their posterior risks are derived under different loss scenarios. In case, no little prior information is available, elicitation of hyper parameters is given. To examine, numerically, the performance of the Bayes estimators using non-informative and informative priors under different loss functions, we have simulated

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Mina, Syeda A., Mohamed Shanshal, Konstantinos Leventakos, and Kaushal Parikh. "Emerging Targeted Therapies in Non-Small-Cell Lung Cancer (NSCLC)." Cancers 17, no. 3 (2025): 353. https://doi.org/10.3390/cancers17030353.

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Targeted therapies have changed the treatment landscape of non-small-cell lung cancer and led to improved patient survival across all stages of lung cancer. Newer advances in common and novel oncogenic drivers continue to occur at vigorous speed, making it challenging to stay up to date with the rapidly evolving field. In this article, we review the emerging perspectives in the treatment of actionable targets in lung cancer. We focus on the development of newer KRAS-directed therapies, particularly on non-G12C mutations, pan-RAS inhibitors, and RAS-GTP inhibitors. We also describe the current

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Vega-Ramos, Flor, Lucas Cifuentes, Fernando Pineda-García, Todd Dawson, and Horacio Paz. "Different dry-wet pulses favor different functional strategies: A test using tropical dry forest tree species." PLOS ONE 19, no. 12 (2024): e0309510. https://doi.org/10.1371/journal.pone.0309510.

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In many terrestrial habitats, plants experience temporal heterogeneity in water availability both at the intra and inter annual scales, creating dry-wet pulse scenarios. This variability imposes two concomitant challenges for plants: surviving droughts and efficiently utilizing water when it becomes available, whose responses are closely interconnected. To date, most studies have focused on the response to drought following static designs that do not consider consequences of repeated transitions from one state to the other. In principle, different dry-wet pulse scenarios among years may differ

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Gargano, Ludmila, Cecilia Farinasso, Haliton Alves De Oliveira Junior, and Rosa Lucchetta. "PD26 Seeking Sustainability For The Brazilian Public Healthcare System: Cost-Utility Analysis Of Pembrolizumab For Advanced Non-Small Cell Lung Cancer." International Journal of Technology Assessment in Health Care 40, S1 (2024): S107. https://doi.org/10.1017/s0266462324002903.

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IntroductionPembrolizumab is used as a monotherapy or in addition to chemotherapy for patients with non-small cell lung cancer (NSCLC) as an alternative to platinum-based chemotherapy. The objective was to conduct a cost-utility analysis for subgroups of patients with NSCLC using the Brazilian Unified Health System (SUS) threshold of BRL120,000 (USD24,458) per quality-adjusted life-year (QALY).MethodsWe built a partitioned survival model with three health states based on overall survival (OS) and progression-free survival (PFS) curves for three scenarios according to programed death ligand-1 (

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Hörner, Johannes, and Aiko Voigt. "Sea-ice thermodynamics can determine waterbelt scenarios for Snowball Earth." Earth System Dynamics 15, no. 2 (2024): 215–23. http://dx.doi.org/10.5194/esd-15-215-2024.

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Abstract. Snowball Earth refers to multiple periods in the Neoproterozoic during which geological evidence indicates that the Earth was largely covered in ice. A Snowball Earth results from a runaway ice–albedo feedback, but there is an ongoing debate about how the feedback stopped: with fully ice-covered oceans or with a narrow strip of open water around the Equator. The latter states are called waterbelt states and are an attractive explanation for Snowball Earth events because they provide a refugium for the survival of photosynthetic aquatic life, while still explaining Neoproterozoic geol

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Tatsumi, Chikae, Takeshi Taniguchi, Fujio Hyodo, Sheng Du, Norikazu Yamanaka, and Ryunosuke Tateno. "Survival Rate, Chemical and Microbial Properties of Oak Seedlings Planted with or without Oak Forest Soils in a Black Locust Forest of a Dryland." Forests 12, no. 6 (2021): 669. http://dx.doi.org/10.3390/f12060669.

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Native tree species are frequently unable to effectively grow in non-native tree cultivation scenarios. In the Loess Plateau, China, it is difficult to find native oak (Quercus liaotungensis) seedlings in non-native black locust forests. Black locust is an arbuscular mycorrhizal (AM) tree, but oak is an ectomycorrhizal (ECM) tree. Plants highly depend on their symbiotic mycorrhizal fungi to take up water, nitrogen (N) and other nutrients. We hypothesized that black locust forests would not provide ECM inoculum to oak seedlings, limiting their water and nutrient uptake, which would be improved

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Wang, Jie-Huei, and Yi-Hau Chen. "Interaction screening by Kendall’s partial correlation for ultrahigh-dimensional data with survival trait." Bioinformatics 36, no. 9 (2020): 2763–69. http://dx.doi.org/10.1093/bioinformatics/btaa017.

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Abstract Motivation In gene expression and genome-wide association studies, the identification of interaction effects is an important and challenging issue owing to its ultrahigh-dimensional nature. In particular, contaminated data and right-censored survival outcome make the associated feature screening even challenging. Results In this article, we propose an inverse probability-of-censoring weighted Kendall’s tau statistic to measure association of a survival trait with biomarkers, as well as a Kendall’s partial correlation statistic to measure the relationship of a survival trait with an in

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Peng, Xiongwu, Lingxing Duan, Qi Wu, Shiping Wu, Wenfeng Wang, and Runlin Shi. "Survival benefits of Cytoreductive Nephrectomy in patients with metastatic renal cell carcinoma: evidence from a SEER-based retrospective cohort study." PLOS One 20, no. 7 (2025): e0318896. https://doi.org/10.1371/journal.pone.0318896.

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Background Metastatic renal cell carcinoma (mRCC) is associated with poor prognosis, with a 5-year survival rate of less than 15%. Cytoreductive nephrectomy (CN) has historically played a critical role in mRCC management, potentially enhancing systemic therapy efficacy by reducing tumor burden. However, its relevance in the era of targeted therapies and immune checkpoint inhibitors (ICIs) has been questioned. Objective This study evaluates the survival benefits of CN in mRCC patients using real-world, population-based data from the SEER database. Methods A retrospective cohort analysis of 6,03

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Smith Hughes, Carolyn, Elizabeth Butrick, Juliana Namutundu, et al. "Cost analysis of an intrapartum quality improvement package for improving preterm survival and reinforcing best practices in Kenya and Uganda." PLOS ONE 18, no. 6 (2023): e0287309. http://dx.doi.org/10.1371/journal.pone.0287309.

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Introduction Preterm birth is a leading cause of under-5 mortality, with the greatest burden in lower-resource settings. Strategies to improve preterm survival have been tested, but strategy costs are less understood. We estimate costs of a highly effective Preterm Birth Initiative (PTBi) intrapartum intervention package (data strengthening, WHO Safe Childbirth Checklist, simulation and team training, quality improvement collaboratives) and active control (data strengthening, Safe Childbirth Checklist). Methods In our analysis, we estimated costs incremental to current cost of intrapartum care

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Woo, Wongi, Brandon Park, Awranoos Ahadi, et al. "The role of pulmonary metastasectomy for non-primary lung cancer: Umbrella review of meta-analysis." Journal of Clinical Oncology 42, no. 16_suppl (2024): 8639. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.8639.

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8639 Background: Lungs are the most common metastatic area for many cancers. Due to heterogeneous characteristics of primary cancers, the benefit of pulmonary metastasectomy (PM) has not been investigated other than colorectal cancers. Furthermore, well-designed trials in this field are difficult to undertake due to diverse clinical scenarios and therapy related to primary cancers. This study aims to investigate the clinical outcomes of PM for non-primary lung cancer by synthesizing existing literature. Methods: A systematic search for meta-analyses on PM for non-primary lung cancers was condu

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Damaso, Vinícius Correa, and Pauli Adriano de Almada Garcia. "Testing and preventive maintenance scheduling optimization for aging systems modeled by generalized renewal process." Pesquisa Operacional 29, no. 3 (2009): 563–76. http://dx.doi.org/10.1590/s0101-74382009000300006.

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The use of stochastic point processes to model the reliability of repairable systems has been a regular approach to establish survival measures in failure versus repair scenarios. However, the traditional processes do not consider the actual state in which an item returns to operational condition. The traditional renewal process considers an "as-good-as-new" philosophy, while a non-homogeneous Poisson process is based on the minimal repair concept. In this work, an approach based on the concept of Generalized Renewal Process (GRP) is presented, which is a generalization of the renewal process

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Arévalo-Ayala, Diego J., Joan Real, Santi Mañosa, Joan Aymerich, Carles Durà, and Antonio Hernández-Matías. "Age-Specific Demographic Response of a Long-Lived Scavenger Species to Reduction of Organic Matter in a Landfill." Animals 13, no. 22 (2023): 3529. http://dx.doi.org/10.3390/ani13223529.

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Food availability shapes demographic parameters and population dynamics. Certain species have adapted to predictable anthropogenic food resources like landfills. However, abrupt shifts in food availability can negatively impact such populations. While changes in survival are expected, the age-related effects remain poorly understood, particularly in long-lived scavenger species. We investigated the age-specific demographic response of a Griffon vulture (Gyps fulvus) population to a reduction in organic matter in a landfill and analyzed apparent survival and the probability of transience after

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Palumbo, Veronica Mariel, and Soraya Palletti. "Relevance of Simulation Practices for Improving the Internalization of Cardiopulmonary Arrest Management Protocols." International Journal of Research and Innovation in Social Science IX, IIIS (2025): 4731–37. https://doi.org/10.47772/ijriss.2025.903sedu0340.

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Effective training in cardiopulmonary arrest (CPA) management is crucial for future healthcare professionals, as timely actions impact survival. Despite standardized AHA protocols, their practical internalization remains difficult. Simulation-based medical education (SBME), particularly with structured debriefing like the PEARLS model, has become essential for developing competencies in safe environments. The objective of this study was to evaluate the relevance of deliberate simulation practices (zones 1 and 2) in improving theoretical understanding and CPA protocol adherence among medical st

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Nevola, Riccardo, Augusto Delle Femine, Valerio Rosato, et al. "Neoadjuvant and Adjuvant Systemic Therapies in Loco-Regional Treatments for Hepatocellular Carcinoma: Are We at the Dawn of a New Era?" Cancers 15, no. 11 (2023): 2950. http://dx.doi.org/10.3390/cancers15112950.

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Despite maximizing techniques and patient selection, liver resection and ablation for HCC are still associated with high rates of recurrence. To date, HCC is the only cancer with no proven adjuvant or neoadjuvant therapy used in association to potentially curative treatment. Perioperative combination treatments are urgently needed to reduce recurrence rates and improve overall survival. Immunotherapy has demonstrated encouraging results in the setting of adjuvant and neoadjuvant treatments for non-hepatic malignancies. Conclusive data are not yet available in the context of liver neoplasms. Ho

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Yuan, Zheng, Mark F. van Delft, Mark Xiang Li, et al. "Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis." PLOS Biology 22, no. 5 (2024): e3002617. http://dx.doi.org/10.1371/journal.pbio.3002617.

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BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial porin VDAC2. VDAC2 is important for bringing both BAK and BAX to mitochondria where they execute their apoptotic function. Despite this important function in apoptosis, while interactions with pro-survival family members are well characterised and have culminated in the development of drugs that target these interfaces to induce cancer cell apoptosis, the inter

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Schönherr, Jacqueline, Philipp Seifert, Falk Gühne, et al. "Transarterial Radioembolization (TARE) in Patients with Hepatocellular Carcinoma: A Comparison of Palliative with Bridging-to-Transplant Concepts." Cancers 16, no. 1 (2024): 235. http://dx.doi.org/10.3390/cancers16010235.

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We investigated transarterial radioembolization (TARE) as a palliative measure and bridging-to-transplant therapy in hepatocellular carcinoma (HCC) patients. A total of 167 patients (50 bridging, 117 palliative) with 245 TARE procedures were assessed. Fourteen patients underwent subsequent liver transplantation (LT). Patients undergoing LT exhibited significantly prolonged progression-free survival (PFS) compared to those with bridging-without-transplant (p = 0.033). No significant differences were observed between patients with bridging-without-transplant and palliative cases (p = 0.116). Med

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Pavanelli, Ana Carolina, Flavia Rotea Mangone, Luciana R. C. Barros, Juliana Machado-Rugolo, Vera L. Capelozzi, and Maria A. Nagai. "Abnormal Long Non-Coding RNAs Expression Patterns Have the Potential Ability for Predicting Survival and Treatment Response in Breast Cancer." Genes 12, no. 7 (2021): 996. http://dx.doi.org/10.3390/genes12070996.

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Abnormal long non-coding RNAs (lncRNAs) expression has been documented to have oncogene or tumor suppressor functions in the development and progression of cancer, emerging as promising independent biomarkers for molecular cancer stratification and patients’ prognosis. Examining the relationship between lncRNAs and the survival rates in malignancies creates new scenarios for precision medicine and targeted therapy. Breast cancer (BRCA) is a heterogeneous malignancy. Despite advances in its molecular classification, there are still gaps to explain in its multifaceted presentations and a substan

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Odisho, Anobel Y., Sumanta K. Pal, Michael Shapiro, et al. "CLOVIZ: Clinical outcomes visualization of IMDC criteria in metastatic renal cell carcinoma for patient-centered decision making." Journal of Clinical Oncology 35, no. 6_suppl (2017): 527. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.527.

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527 Background: The International Metastatic Renal Cell Carcinoma Database (IMDC) Criteria (Heng Criteria) is a validated risk prediction tool for patients with metastatic renal cell carcinoma (mRCC). It provides valuable prognostic data but clinical application can be challenging due to limited available tools. We created an interactive visualization to facilitate clinical application of IMDC Criteria. Methods: A multi-institutional cohort of 436 patients with mRCC was used to create an interactive visualization depicting IMDC Criteria at the patient level. Usability testing was performed wit

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Tomšič, Sonja, Vesna Zadnik, Maja Pohar Perme, Tina Žagar, Katja Jarm, and Bor Vratanar. "Evaluation of the Slovenian Breast Cancer Screening Programme: Years of Life Gained and Avoided Deaths." Cancers 17, no. 5 (2025): 742. https://doi.org/10.3390/cancers17050742.

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Background: Most commonly, mortality is used for evaluation of organized breast cancer screening programmes. Survival analyses are also being employed to provide more timely assessment. A novel approach has been introduced for calculating survival using Slovenian data. Methods: Breast cancer cases from the Slovenian Cancer Registry between 2008–2021 in women aged 50 to 72 were included, supplemented by data on the screening history from the screening registry. The comparison was made in two scenarios—invited or not invited to the screening. Survival, years of life gained, and number of avoided

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Mai, Vu Quynh, Lars Lindholm, Hoang Van Minh, Sun Sun, Kim Bao Giang, and Klas-Göran Sahlén. "Cost-effectiveness of consolidation durvalumab for inoperable stage III non-small cell lung cancer in Vietnam." BMJ Open 14, no. 8 (2024): e083895. http://dx.doi.org/10.1136/bmjopen-2024-083895.

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Background This study aimed to assess the cost-effectiveness of durvalumab as a treatment option for patients with inoperable stage III non-small cell lung cancer (NSCLC) from healthcare and partial societal perspectives in Vietnam. Method A lifetime partitioned survival model was used to evaluate the costs and quality-adjusted life years (QALYs) associated with consolidation durvalumab in comparison with the standard of care alone. Local costs and utilities were incorporated into the model. In the base-case analysis, no discount was applied to the acquisition cost of durvalumab. Scenario-base

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Vieira, Hugo C., Andreia C. M. Rodrigues, Sílvia F. S. Pires, et al. "Ocean Warming May Enhance Biochemical Alterations Induced by an Invasive Seaweed Exudate in the Mussel Mytilus galloprovincialis." Toxics 9, no. 6 (2021): 121. http://dx.doi.org/10.3390/toxics9060121.

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Ocean warming and biological invasions are among the most pervasive factors threatening coastal ecosystems with a potential to interact. Ongoing temperature rise may affect physiological and cellular mechanisms in marine organisms. Moreover, non-indigenous species spread has been a major challenge to biodiversity and ecosystem functions and services. The invasive red seaweed Asparagopsis armata has become successfully established in Europe. Its exudate has been considered deleterious to surrounding native species, but no information exists on its effect under forecasted temperature increase. T

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Vera-Escalona, Iván, Lucas H. Gimenez, and Antonio Brante. "Short-Term and Long-Term Predictions: Is the Green Crab Carcinus maenas a Threat to Antarctica and Southern South America under a Climate-Change Scenario?" Diversity 15, no. 5 (2023): 632. http://dx.doi.org/10.3390/d15050632.

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Non-native species can have profound implications on the survival of native ones. This is especially true for some invasive crabs, such as the green crab Carcinus maenas, a native species to the Northern Hemisphere that has been introduced into southern Argentina, from where it could expand through Argentina, Chile, and the Antarctic Peninsula. Hence, there is interest in forecasting changes in C. maenas habitat suitability through time to predict if potential future invasions might occur. Here, by using a Species Distribution Model (SDM) approach, we estimated the habitat suitability for C. m

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Liu, Qi, Jianyang Ye, Zujie Kang, et al. "Reeve’s Muntjac (Muntiacus reevesi) Habitat Suitability Under Climate Change Scenarios in Hupingshan National Nature Reserve, China." Animals 15, no. 2 (2025): 160. https://doi.org/10.3390/ani15020160.

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Climate change and human disturbance are critical factors affecting the habitat distribution of wild animals, with implications for management strategies such as protecting migration corridors, habitat restoration, and species conservation. In the Hupingshan National Nature Reserve (NNR), Reeve’s muntjac (Muntiacus reevesi) is a key prey species for the South China tiger (Panthera tigris amoyensis), which is extinct in the wild and targeted for reintroduction by the Chinese government. Thus, understanding the habitat distribution and abundance of Reeve’s muntjac is essential to ensure the surv

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