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Autor: Grafiati

Data publikacji: 7 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Meyer, Aline Katharina [Verfasser], and Christoph [Akademischer Betreuer] Sarrazin. "Bedeutung eines prädizierten Leuzinzippermotivs im NS4B-Protein des Hepatitis-C-Virus für NS4B-Proteininteraktionen / Aline Katharina Meyer. Betreuer: Christoph Sarrazin." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/105290498X/34.

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Lundin, Marika. "Topology and membrane rearrangements of the hepatitis C virus protein NS4B /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-927-0/.

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Gretton, Sarah N. "Topology and biophysical characterisation of the hepatitis C virus NS4B protein." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433078.

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Ismail, Rosmani. "Elucidation of the mechanism of action of a mutation in the dengue virus NS4B protein that confers a persistent phenotype in cell culture." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684745.

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Dengue viruses (DENVs) are mosquito-borne flaviviruses, which are responsible for a wide range of illnesses, from a mild febrile illness to the more serious dengue haemorrhagic fever and dengue shock syndromes. The DENV NS4B is a highly hydrophobic integral ER membrane protein that has been reported to perturb type I interferon (IFN) signalling and has emerged as a major target for anti-viral strategies. The objective of this study was to determine the mechanism of action of two consecutive nucleotide mutations in the NS4B gene (nt 7020 and 7021) that result in the substitution of threonine 66

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Lindström, Hannah Kim. "Molecular studies of the hepatitis C virus : the role of IRES activity for therapy response, and the impact of the non-structural protein NS4B on the viral proliferation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-875-4/.

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Machmouchi, Dana. "Exploring the Pathogenic Mechanisms of West African Zika Virus : viral Replication and Host Interaction." Electronic Thesis or Diss., La Réunion, 2024. https://elgebar.univ-reunion.fr/login?url=http://thesesenligne.univ.run/24_14_D_MACHMOUCHI.pdf.

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Le virus Zika (ZIKV), historiquement limité à l'Afrique et à l'Asie, est devenu une préoccupation mondiale majeure, surtout après les épidémies récentes dans les Amériques associées à des malformations congénitales graves et des troubles neurologiques. Bien que la recherche se soit principalement concentrée sur le génotype asiatique/américain, des preuves croissantes montrent que les souches africaines du ZIKV pourraient également représenter une menace sévère, notamment en termes de pathogénicité fœtale. Cette thèse vise à améliorer notre compréhension des mécanismes moléculaires de la pathog

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Zwart, Lizahn. "Investigating two AHSV non-structural proteins : tubule-forming protein NS1 and novel protein NS4." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/62198.

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African horse sickness is an equid disease caused by African horse sickness virus (AHSV). AHSV produces seven structural proteins that form the virion and four non-structural proteins with various roles during replication. The first part of this study investigated the intracellular distribution and co-localisations of NS1 with other AHSV proteins to facilitate its eventual functional characterisation. Confocal microscopy revealed that NS1 formed small cytoplasmic foci early after infection that gradually converged into large fluorescent NS1 tubule bundles. Tubule bundles were more organised in

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Taylor, Annette Irene. "The intracellular localisation and membrane-altering properties of hepititis C virus proteins NS4B and NS5A." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274768.

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Jin, Yi. "Characterisation of the African horse sickness virus NS4 protein." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8973/.

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African horse sickness is one of the most deadly infectious diseases of horses. The disease is caused by African horse sickness virus (AHSV), an arbovirus transmitted by culicoides midges. AHSV is classified within the genus Orbivirus, family Reovirdae. The AHSV genome is composed by ten segments of double stranded RNA (dsRNA) encoding seven structural and at least four non-structural (NS) proteins. AHSV shares structural and functional similarities with Bluetongue virus, the ‘prototype’ species of the genus Orbivirus. An alternative open reading frame (ORF), overlapping the main ORF encoding

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Choi, Yook-Wah. "Structural and functional characterization of human DDX5 and its interaction with NS5B of hepatitis C virus." University of the Western Cape, 2011. http://hdl.handle.net/11394/5299.

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Philosophiae Doctor - PhD<br>Hepatitis C was first recognized as a transfusion-associated liver disease not caused by hepatitis A or hepatitis B virus after serological tests were developed to screen for their presence in the blood. The infectious agent was finally identified with the cloning of the cDNA of hepatitis C virus (HCV) using random polymerase chain reaction (PCR) screening of nucleic acids extracted from plasma of a large pool of chimpanzee infected with non-A non-B hepatitis. NS5B, a membrane-associated RNA-dependent RNA polymerase essential in the replication of HCV, initiates

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Martin, Morgan Mackensie. "Functional analysis of hepatitis C virus non-structural protein (NS) 3 protease and viral cofactor NS4A." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1522.

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The hepatitis C virus (HCV) was identified in 1989 as the major causative agent of transfusion-associated non-A, non-B hepatitis and today represents a worldwide health crisis with prevalence estimates of 2.2%. HCV-specific therapeutics have never been more urgently needed. One of the validated drug targets is the non-structural (NS) protein 3 (NS3) membrane-bound protease. The major aim of this thesis was characterization of NS3 allosteric activation by its viral cofactor, NS4A. We hypothesized that there would be specific residues that dominate the interaction between NS3 and NS4A, and furth

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Meguellati, Amel. "Synthèse de biomolécules agissant comme inhibiteurs de l'ARN polymérase ARN dépendante du virus de l'hépatite C et développement de nouveaux surfactants comme stabilisants des protéines membranaires par réseaux de ponts salins." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GRENV001.

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Le projet de thèse se focalise sur la synthèse de biomolécules et se subdivise en deux parties. La première partie concerne la conception et la synthèse de dérivés de produits naturels d'intérêt thérapeutique nommés aurones en vue de mettre au point de nouvelles molécules à activité antivirale. Récemment, les aurones ont été identifiées comme étant des inhibiteurs de l'ARN-polymérase ARN-dépendante (NS5B) du virus de l'hépatite C (VHC). Cette enzyme, présente chez le virus mais absente chez l'homme, joue un rôle central dans la réplication virale. Suite à ces résultats antérieurs, les efforts

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Hung, Yu Fu Verfasser], and Dieter [Akademischer Betreuer] [Willbold. "Biophysical characterization of the N-terminal region of Dengue virus NS4A protein / Yu -Fu Hung. Gutachter: Dieter Willbold." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2014. http://d-nb.info/1059855232/34.

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Mamigonian, Bessa Luíza. "Investigation of the hepatitis C virus RNA polymerase NS5B in solution by nuclear magnetic resonance and its interaction with intrinsically disordered domain 2 of the NS5A protein." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10117/document.

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NS5B est l’ARN polymérase du virus de l’hépatite C (VHC). Sa structure a beaucoup été étudiée par radiocristallographie, elle contient trois sous-domaines appelés doigts, paume et pouce. Cependant, les études structurales de cette protéine en solution sont très limitées. La résonance magnétique nucléaire (RMN) a été utilisée pour étudier NS5B en solution ainsi que son interaction avec différents partenaires. L’emploi d’un échantillon de NS5B (65kDa) perdeuterée et sélectivement enrichie au niveau des méthyles 1 des résidus d’isoleucines a permis d’obtenir un spectre simplifié et de bonne qual

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Dünnes, Nadia [Verfasser]. "Analyse der Interaktion von microRNA-122-Protein-Komplexen mit der NS5B-kodierenden Region und der 3´-untranslatierten Region der Hepatitis C Virus-RNA / Nadia Dünnes." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1118289773/34.

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Kuo, Yi-Chen, and 郭逸楨. "The NTPase Activity of Hepatitis C Virus NS4B protein." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/47366072821472642267.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>93<br>Hepatitis C virus (HCV) is a major cause of liver disease worldwide. HCV contains a positive-stranded RNA genome of 9.6 kilobases encodes a polyprotein of about 3000 amino acid residues. The polyprotein undergoes cellular and viral protease processing to generate structural and nonstructural proteins. Nonstructural protein 4B (NS4B) is a relatively hydrophobic 27 kDa protein of unknown function. NS4B has four transmembrane segments and has the ability to induce a tight structure formation as membranous web. It is proposed that HCV NS5B RNA polymerase form

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楊馥嘉. "Functional Expression of Nonstructural Proteins NS2A, NS2B, NS4A, and NS4B of Dengue Virus Type 2 PL046 Strain." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/92535778180784776173.

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Racine, Marie-Eve. "Étude du réseau d'interactions entre les protéines du Virus de l'Hépatite C." Thèse, 2007. http://hdl.handle.net/1866/7243.

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Lin, Hsu Jye, and 徐婕琳. "Expression of Nonstructural Proteins: NS2A, NS2B, NS4A, and NS4B of Dengue Virus Type 2 PL046 in E. coli, Mammalian, and Pichia pastoris Expression Systems." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/19256682776855580136.

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碩士<br>國立交通大學<br>生物科技研究所<br>91<br>Dengue virus is a member of flaviviridas, which cause many infectious diseases of human. Dengue virus encodes 11 proteins in a single open reading frame. Among them, NS2A, 2B, 4A and 4B are small non-structural proteins exhibiting conserved hydrophobicity profiles among flaviviuses, suggesting their roles as membrane-associated proteins. Only NS2B has been suggested to be involved in protease activity. Specific biological functions for NS2A, 4A and 4B have not been identified. To delineate the structure and function of these four proteins, I ttempted to establi

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(8623374), Shishir Poudyal. "A COMBINED GENETIC AND CHIMERIC ANALYSIS OF THE FLAVIVIRAL NON-STRUCTURAL PROTEINS." Thesis, 2020.

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<p>A successful flaviviral life cycle involves several coordinated events between viral proteins and host factors. The polyprotein processing at the surface of the ER membrane results in the formation of several replication proteins that bring about changes in the ER membrane making it permissive for viral genome amplification. Non-structural proteins 4A (NS4A) and non-structural protein 4B (NS4B) are two of the most important integral membrane proteins of DENV that are essential part of the viral replicase complex. The cleavage at NS4A-2K-NS4B is temporally and spatially regulated. The cleava

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Chen, Ming-Yuan, and 陳明圓. "Hepatitis C Virus Nonstructural Protein 5B (NS5B) Interacts with Akt." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/87849171233555725407.

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碩士<br>國立陽明大學<br>藥理學研究所<br>96<br>Hepatitis C virus (HCV) is recognized as a major causative agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The phosphatidylinositol 3-kinase (PI3K)–Akt pathway is utilized by many viruses, including HBV and HCV, for inhibition of apoptosis of infected cells. Akt, a serine/threonine kinase, is a substrate of PI3K and acts as an important signal mediator of cell survival following activation. The HCV NS5B, a putative serine phosphoprotein, is the viral RNA-dependent RNA polymerase (RdRP) required for replication of the HCV RNA genome. The phos

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Henningson, Jamie N. "Influence of BVDV nonstructural proteins N(pro) and NS4B on virulence in experimental acutely infected calves." 2008. http://proquest.umi.com/pqdweb?did=1584072581&sid=3&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Nebraska-Lincoln, 2008.<br>Title from title screen (site viewed Jan. 13, 2009). PDF text: vii, 268 p. : col. ill. ; 5 Mb. UMI publication number: AAT 3321565. Includes bibliographical references. Also available in microfilm and microfiche formats.

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Wang, Yi-Ming, and 王怡敏. "The Mechanisms of Hepatitis C Virus NS4A Protein on the Inhibition of Protein Synthesis and theInternal Cleavage of NS3 Protein." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/23492695413222383664.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>93<br>Hepatitis C virus (HCV) is a positive, single-stranded RNA virus. Previous studies have demonstrated that the viral nonstructural protein NS4A interacts with NS3 and is a cofactor of NS3 serine protease essential for the proteolytic processing of the viral polyprotein. NS4A protein was also demonstrated to inhibit cellular and viral protein synthesis. By performing GST pull down assay, our laboratory has previously identified eEF1A that specifically interacted with NS4A. The purpose of this study was to examine whether NS4A inhibits protein translation via inte

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Tseng, Fan-Wei, and 曾繁偉. "Hepatitis C Virus Nonstructural Protein 5B (NS5B) is a Substrate of Akt." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89612733234015073934.

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碩士<br>國立陽明大學<br>藥理學研究所<br>96<br>Hepatitis C virus (HCV) is a positive, single-stranded RNA virus. It belongs to the family of Flaviviridae. There are six major genotypes of HCV and the most common in Taiwan is 1b. HCV can generate more than ten proteins. The non-structural protein NS5B, identified as a RNA dependent RNA polymerase (RdRp), plays an important role in HCV replication. We noticed that the NS5B of HCV genotype 1 has the consensus sequence of the Akt/PKB substrate. Akt/PKB is a Ser/Thr-protein kinase which plays important roles in the cell such as cell metabolism, glucose uptake, an

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曹昌煇. "Study of Membrance Permeability Modified by Japanese Encephalitis Virus Nonstructural Protein NS2b." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/01394049417075570382.

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碩士<br>國防醫學院<br>微生物暨免疫學研究所<br>85<br>Membrane permeability was reported to be modified by various animal virus during infection and the viral proteins responsible for this modification has been determined for poliovirus, influenza virus and HIV, etc. by an E. coli inducible system. In this study, the ability of the membrane permeability modification by Japanese encephalitis virus (JEV) nonstructural protein NS2b~NS3 was determined by the inducible system. Overexpression of NS2b plus various lengths of NS3 in E. coli causd membrane permeability change demonstrated by the entry of protein translat

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Huang, Jing-Tang, and 黃景堂. "PROTEOMIC APPROACHES TO IDENTIFY HEPATITIS C VIRUS NS5B RNA POLYMERASE-INTERACTING PROTEINS." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/64850437781298980141.

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碩士<br>中國醫藥大學<br>醫學研究所<br>93<br>Abstract Hepatitis C virus (HCV) nonstructure protein 5B (NS5B) is a RNA-dependent RNA polymerase that acts as a key player in the HCV replication complex. Some viral and cellular factors were reported to involve in HCV replication. However, the components of the HCV replication complex are still not yet completely understood. In this study, the HCV NS5B was used as the bait in a pull down assay to screen for NS5B-interacting proteins present in Huh 7 hepatoma cells. After mass spectrophotometric analysis, a putative lipogenic enzyme, fatty acid synthase (FAS), w

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Huang, Yu-Hsu, and 黃裕煦. "Hepatitis C virus NS4A protein regulates clusterin expression and caspase-3 activity of host cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/06270102090872298157.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>95<br>Hepatitis C virus (HCV) NS4A is a nonstructural protein of about 6 kDa that consists of 54 amino acids. The well-known function of NS4A is the cofactor of NS3 serine protease that promotes the HCV polyprotein processing. NS4A also uses its central domain to interact with NS3 serine protease and to promote NS3 internal cleavage. A recent study demonstrated that NS4A accumulates on mitochondria membrane and induces mitochondria-mediated cell apoptosis and caspase-3 activation. cDNA microarray analysis from our laboratory revealed an increase of clusterin (CLU) mR

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Lin, Yu Chieh, and 林雨潔. "Effects of Different Domains of the HCV NS3- NS4A Protein on Its RNA Helicase Activity." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/15861932597428236170.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>90<br>Hepatitis C virus (HCV) is the major etiological agent of post- transfusion- associated non- A, non- B hepatitis worldwide. An estimated 3 % of the world’s population is infected with HCV, according to the World Health Organization. HCV infection most commonly results in chronic hepatitis that eventually develops into cirrhosis and hepatocellular carcinoma. The current available therapy, using interferon- α and combination with ribavirin, has worked on less than 50 % of the patients. Therefore, there is an urgent need for new therapies. The non-struc

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Kou, Yi-Hen, and 寇怡衡. "Molecular mechanisms of NS3 and NS4A proteins involved in the pathogenesis of hepatitis C virus." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/36322031036572804712.

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博士<br>國立臺灣大學<br>微生物學研究所<br>95<br>The genomic RNA of hepatitis C virus (HCV) encodes the viral polyprotein precursor that undergoes proteolytic cleavage into structural and nonstructural proteins by cellular and the viral NS2-3 and NS3 proteases. NS4A is a cofactor of the NS3 protease. The NS3 protein was previously found to be internally cleaved but the mechanism is unclear. In this study, internal cleavages were demonstrated with the NS3 protein of genotype 1b in the presence of NS4A. Three potential cleavage sites were detected in the NS3 protein (genotype 1b) with IPT402|S being the major o

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Kou, Yi-Hen. "Molecular mechanisms of NS3 and NS4A proteins involved in the pathogenesis of hepatitis C virus." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2507200714162700.

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Xia, Shuangluo. "High throughput screening of inhibitors for influenza protein NS1." 2009. http://hdl.handle.net/2152/14126.

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Influenza virus A and B are common pathogens that cause respiratory disease in humans. Recently, a highly virulent H5N1 subtype avian influenza virus caused disease outbreaks in poultry around the world. Drug resistant type A viruses rapidly emerged, and the recent H5N1 viruses were reported to be resistant to all current antiviral drugs. There is an urgent need for the development of new antiviral drugs target against both influenza A and B viruses. This dissertation describes work to identify small molecule inhibitors of influenza protein NS1 by a high throughput fluorescence polarization as

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Cheng, Ju-Chien, and 鄭如茜. "Molecular Mechanisms of the nonstructural proteins NS5B and NS3 Involved in teh Replication of Hepatitis C Virus." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/78376461821549977686.

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博士<br>國立臺灣大學<br>微生物學研究所<br>88<br>Hepatitis C virus (HCV) is the major etiology agent of posttransfusion and sporadic, community acquired non-A, non-B hepatitis. It plays a major role in the development of chronic hepatitis and hepatocellular carcinoma. The viral particle possesses a positive-sense RNA genome that contains a large open reading frame encoding a polyprotein about 3000 amino acid residues. Generation of mature proteins from the polyprotein precursor is mediated by cellular and viral proteases. Amino acid sequence analysis revealed highly conserved function motifs within

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Sridharan, Haripriya. "The interaction between NS1B protein of influenza B virus and the ubiquitin-like modifier ISG15 : insights into a unique species specific property of the virus." Thesis, 2009. http://hdl.handle.net/2152/21917.

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Influenza B virus causes a respiratory disease in people with a compromised immune system. The NS1B protein of influenza B virus is essential for virus growth and plays a crucial role in inhibiting the anti-viral responses mounted by the infected host cell. The N terminal 104 amino acids of NS1B bind a cellular protein called ISG15. ISG15 is an interferon induced 'ubiquitin-like' protein, and upon interferon induction, is conjugated to hundreds of targets. It has been found that both ISG15 and its conjugation inhibit many viruses. The focus of the current study was to characterize the interact

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Liu, Chun-Lin, and 劉俊麟. "DENV NS2B/NS3 Structural Protein Cleavage Insufficiency Is Not the Cause of NS3 N369 Mutation-induced Virus Production Defect." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/70029427814005613331.

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Lan, Min-Shu, and 藍敏書. "Expression of Dengue Virus Proteins NS1, NS2, NS4 and E in E.coli C41 and C43 Expression Strains." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/35955526977058269023.

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碩士<br>國立交通大學<br>生物醫學研究所<br>97<br>Dengue virus is a member of family Flaviviridae, genus of Flavivirus. Dengue viruses cause dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Dengue virus encodes 10 proteins in a single open reading frame, including 3 structural proteins and 7 non-structural proteins. Envelope protein is one of the structural proteins locates outside of the virus particle, which can bind to receptors on host cells and causes infection. NS2A, 2B, 4A and 4B are small non-structural proteins which are membrane-associated proteins exhibiting hydrophobic profiles. NS

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Stocks, Christine Edith. "A Study of the mechanism and role of coordinated cleavages by signal peptidase and viral NS2B-3 protease at the C-prM junction in the structural protein region of the flavivirus polyprotein." Phd thesis, 2001. http://hdl.handle.net/1885/145717.

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