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Artykuły w czasopismach na temat „NSAIDs VAS and WOMAC”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Zavodovskiy, B. V., E. V. Papichev, L. E. Sivordova, Yu V. Polyakova, and Yu R. Akhverdyan. "The Comparative Efficacy and Safety of Long- and Short-Term Continuous Use of Non-Steroidal Anti-Inflammatory Drugs for the Treatment of Knee Osteoarthritis." Traumatology and Orthopedics of Russia 26, no. 2 (2020): 120–27. http://dx.doi.org/10.21823/2311-2905-2020-26-2-120-127.

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Objective. To compare the efficacy and tolerability of long-term and short-term continuous NSAIDs in patients with knee osteoarthritis with insufficient efficacy “on demand” NSAIDs and SYSADOA.Study design. 12-week, prospective, comparative, randomized, single-center study.Materials and Methods. 180 patients with primary knee osteoarthritis aged 40 to 85 years with insufficient efficacy of “on demand” NSAIDs and SYSADOA were examined. Anti-inflammatory drugs were recommended for everyone: 56 people took Naproxen (31.11%), 63 — Etoricoxib (35%), 61 — Ketoprofen (33.89%). Patients were randomize

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Khan Panezai, Muhammad Muddasser, Shahzad Gul, Zia Ehsan Kakar, Uzma Rasheed, Shazia Zammurad, and Saira Tahir. "Comparison of NSAIDS Versus NSAIDS Plus Duloxetine in Knee Osteoarthritis Patients." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 2865–68. http://dx.doi.org/10.53350/pjmhs2115102865.

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Objective: To compare the efficacy of Duloxetine with NSAIDS versus NSAIDS alone for the treatment of knee pain secondary to osteoarthritis. Study Design: Randomized clinical trial study. Setting and Duration: Department of Rheumatology, PIMS Hospital, Islamabad, from April to August 2021. Methodology: One hundred and twenty eight patients with knee osteoarthritis were included in the study and were divided in two equal groups; one group was subjected to Duloxetine plus NSAIDs and other to just NSAIDs. The response was assessed at end of 3 months. Reduction in pain more than or equal to 50% fr

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Filatova, E. S., A. E. Karateev, S. I. Glukhova, and A. M. Lila. "The efficacy of a complex of vitamins B 1, B6 and B 12 in combination with nonsteroidal antiinflammatory drugs for pain control in osteoarthritis: meta-analysis of randomized controlled trials." Modern Rheumatology Journal 19, no. 2 (2025): 84–91. https://doi.org/10.14412/1996-7012-2025-2-84-91.

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Pain control is the most important task in the complex treatment of osteoarthritis (OA). One of the promising methods to increase the efficacy of analgesics in OA may be the combined use of nonsteroidal antiinflammatory drugs (NSAIDs) with a complex of vitamins B1, B6 and B12 (СVB).Objective: to evaluate the efficacy of combination of NSAIDs + CVB compared to monotherapy with NSAIDs in the treatment of knee OA using a meta-analysis of randomized controlled trials (RCTs).Material and methods. We selected articles during the period 1981–2024 years using electronic databases PubMed (English-langu

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Nair, Sreeni, Anish Desai, Sunaina Anand, and Parita Chorghe. "Assessing the effectiveness and NSAIDs sparing effect of celery seeds and Boswellia serrata in osteoarthritis management." Indian Journal of Orthopaedics Surgery 10, no. 4 (2024): 318–23. https://doi.org/10.18231/j.ijos.2024.052.

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: This study examines the anti-inflammatory and analgesic properties of Celery seed and extracts as potential alternatives for OA treatment, focusing on their effectiveness in reducing pain and improving joint functionality.Osteoarthritis (OA), a prevalent joint disorder, particularly affects the knees and hips. Current management primarily involves NSAIDs, which can lead to severe side effects, especially in older adults with comorbidities. A multicentre observational study enrolled 394 participants clinically diagnosed with knee osteoarthritis. They continued their usual treatment while taki

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Huang, Hetao, Jianke Pan, Weiyi Yang, et al. "Are Kidney-Tonifying and Blood-Activating Medicinal Herbs Better than NSAIDs for Knee Osteoarthritis? A Systematic Review and Meta-Analysis." Evidence-Based Complementary and Alternative Medicine 2019 (November 25, 2019): 1–19. http://dx.doi.org/10.1155/2019/9094515.

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Objective. To compare the efficacy and safety of kidney-tonifying and blood-activating medicinal herbs (KTBAMs) and nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of knee osteoarthritis (KOA). Methods. Randomized controlled trials (RCTs) from online databases that compared the efficacy of KTBAMs and NSAIDs in the treatment of KOA were retrieved. The main outcomes included the evaluation of functional outcomes, pain, and adverse effects. The Cochrane risk-of-bias (ROB) tool was used to assess methodological quality. Results. A total of 38 RCTs (3994 participants) were included i

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Alekseeva, L. I., N. G. Kashevarova, E. A. Taskina, et al. "The efficacy and safety of intra-articular application of a combination of sodium hyaluronate and chondroitin sulfate for osteoarthritis of the knee: a multicenter prospective study." Terapevticheskii arkhiv 92, no. 5 (2020): 46–54. http://dx.doi.org/10.26442/00403660.2020.05.000631.

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in 3 mL on patients with knee osteoarthritis (OA) in a multicenter prospective study. Materials and methods. 79 outpatients (predominantly females 81.0%) from 5 RF constituent territories with primary tibiofemoral KellgrenLawrence score grade II or III knee OA, 40 mm pain intensity during walking on visual analogue scale (VAS), requiring NSAIDs intake (for at least 30 days during 3 months prior to enrollment) were included into the study after signing the informed consent form. Mean age was 60.38.7 years, mean BMI 29.24.7 kg/m2, disease duration 6 (310) years. Grade II OA was documented

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Farpour, Hamid Reza, Najme Rajabi, and Bahareh Ebrahimi. "The Efficacy of Harpagophytum procumbens (Teltonal) in Patients with Knee Osteoarthritis: A Randomized Active-Controlled Clinical Trial." Evidence-Based Complementary and Alternative Medicine 2021 (October 19, 2021): 1–8. http://dx.doi.org/10.1155/2021/5596892.

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Purpose. The high prevalence of knee osteoarthritis (KOA) is a major cause of disability among elders. NSAIDs are recommended to reduce KOA patients’ symptoms, but their adverse side effects limit their consumption. In this study, we evaluated the effectiveness of Harpagophytum procumbens compared to a routine NSAID (meloxicam) on pain reduction and functional improvement of KOA patients. Patients and Methods. Sixty patients aged 40–60 years, with painful knee osteoarthritis (grades 1-2 of Kellgren–Lawrence scale) for at least one month, were randomized into two groups with different routine m

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Cicero, Arrigo F. G., Nicolò Girolimetto, Crescenzio Bentivenga, Elisa Grandi, Federica Fogacci, and Claudio Borghi. "Short-Term Effect of a New Oral Sodium Hyaluronate Formulation on Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial." Diseases 8, no. 3 (2020): 26. http://dx.doi.org/10.3390/diseases8030026.

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Objective: the aim of this pilot study was to test the short-term effect of oral supplementation with a sodium hyaluronate with a large spectrum of molecular weights (FS-HA®) on the symptoms and functionality of knee osteoarthritis (OA). Methods: 60 subjects affected by clinical and/or radiological diagnosis of symptomatic knee OA were consecutively enrolled in a randomized, double blind, placebo-controlled, clinical trial. At randomization visit, at day 28 (visit 2), and day 56 (visit 3), the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), the Lequesne Functional Index (LF

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Cioroianu, George Ovidiu, Alesandra Florescu, Cristiana Eugenia Simionescu, Teodor Nicuşor Sas, Dănuţ Nicolae Tarniţă, and Otilia Constantina Rogoveanu. "The therapeutic benefits of NSAIDs and physical therapy in knee osteoarthritis." Romanian Journal of Morphology and Embryology 65, no. 2 (2024): 217–24. http://dx.doi.org/10.47162/rjme.65.2.08.

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Introduction: Osteoarthritis (OA) has been established as a progressive wear and tear disease of the synovial joints, which also involves a certain degree of inflammation. Considering there is no disease modifying medication available at the moment, the current guidelines focus on the symptomatic treatment of the affection. Our study aimed to evaluate the therapeutic advantages of the synergistic use of non-steroidal anti-inflammatory drugs (NSAIDs) and physical therapy in the treatment of knee osteoarthritis (KOA). Patients, Materials and Methods: The study comprised 46 individuals who were d

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Pinkaew, Decha, Kanokwan Kiattisin, Khanittha Wonglangka, and Pisittawoot Awoot. "Efficacy and Safety of Phyllanthus Amarus Cream Treatment in Knee Osteoarthritis." Open Sports Sciences Journal 13, no. 1 (2020): 97–104. http://dx.doi.org/10.2174/1875399x02013010097.

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Background: Knee osteoarthritis (OA) is a chronic degenerative joint disease and inflammatory pain which decreases daily activities. Objective: The aim of the present investigation was to examine skin permeation and skin irritation test of Phyllanthus Amarus (PA) cream including the effects of four weeks of treatment with PA cream in patients with osteoarthritis (OA) of the knee. Methods: The permeation study of PA cream was determined by Franz diffusion cells using a stillborn piglet skin. The primary irritation test was evaluated in rabbits and human volunteers following the Draize test. The

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Hong, Mao, Chongjie Cheng, Xiaowei Sun, et al. "Efficacy and Safety of Intra-Articular Platelet-Rich Plasma in Osteoarthritis Knee: A Systematic Review and Meta-Analysis." BioMed Research International 2021 (April 29, 2021): 1–14. http://dx.doi.org/10.1155/2021/2191926.

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Background. Knee osteoarthritis (KOA) is a common disease in aged adults. Intra-articular (IA) injection of platelet-rich plasma (PRP) therapy is an effective minimally invasive treatment for KOA. We aimed to compare the efficacy and safety of platelet-rich plasma (PRP) with placebo or other conservative treatments. Methods. We conducted a meta-analysis to identify relevant articles from online register databases such as PubMed, Medline, Embase, and the Cochrane Library. The primary outcomes were the visual analogue scale (VAS) score, Western Ontario and McMaster Universities Arthritis Index (

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Letaeva, M., M. Koroleva, O. Malyshenko, J. Averkieva, and T. Raskina. "AB0981 DYNAMICS OF PAIN ACCORDING TO THE VAS SCALE, FUNCTIONAL ACTIVITY ACCORDING TO THE WOMAC INDEX AND QUALITY OF LIFE ACCORDING TO THE EQ-5D QUESTIONNAIRE IN ELDERLY AND SENILE PATIENTS WITH KNEE JOINT OSTEOARTHRITIS AFTER COVID-19." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1617.1–1617. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2532.

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ObjectivesTo evaluate the dynamics of pain on the VAS scale, functional activity according to the WOMAC index and quality of life according to the EQ-5D questionnaire in elderly and senile patients with knee joint osteoarthritis (OA) after COVID-19.MethodsA total of 32 elderly and senile male patients with an established diagnosis of knee joint OA (according to the criteria of ACR, 1986) of stage II–III according to Kellgren–Lawrence, with pain ≥40 mm on a visual analog scale (VAS), who needed to take nonsteroidal anti-inflammatory drugs (NSAIDs), were included in the study. The median age of

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Timmons, Ruben Berrocal, Kiminobu Sugaya, and Lori Deneke Bane. "Homologous Use of Allogeneic Umbilical Cord Tissue to Reduce Knee Pain and Improve Knee Function." Life 12, no. 2 (2022): 260. http://dx.doi.org/10.3390/life12020260.

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To determine if knee pain subjects who received cryopreserved umbilical cord tissue (UCT) injected into knee joints experience less knee pain, better function, decreased physical limitations, and reduction of medications (opiates, NSAIDs, and acetaminophen) over a 24 week period, Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and medication usage data were recorded for 30 consenting human knee pain subjects receiving UCT at a single site in the United States. Subject profile information was gathered and analyzed to gain insight into the effec

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Sharma, Sashmit, Kiran Prasad Rijal, Tanup Prasai, and Himal Khanal. "Comparative Study of Efficacy and Safety of Diacerein versus Acelofenac in Patient with Knee Osteoarthritis." Nepal Journal of Medical Sciences 6, no. 1 (2021): 26–33. http://dx.doi.org/10.3126/njms.v6i1.36729.

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Introduction: There are different pharmacological modalities currently in practice for the treatment of osteoarthritis knee. Broadly these are divided into anti-inflammatory drugs such as NSAIDs and symptomatic slow-acting drugs in osteoarthritis (SYSADOA). Diacerein, an anthraquinone derivative inhibits IL-1b and has been shown to significantly decrease the symptoms.Methods: This is open label, prospective comparative study. Total 40 patients were divided into two groups: group A (diacerein) and group B (aceclofenac) by alternate method. In group A diacerein was given 50mg orally for 1 week f

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Jhan, Shun-Wun, Ching-Jen Wang, Kuan-Ting Wu, et al. "Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees." Biomedicines 10, no. 2 (2022): 202. http://dx.doi.org/10.3390/biomedicines10020202.

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Conservative treatments for early osteoarthritis (OA) of the knee included the use of non-steroid anti-inflammatory drugs (NSAIDs) and intra-articular hyaluronic acid (HA) injection. Recently, several animal studies reported that extracorporeal shockwave therapy (ESWT) demonstrated chondroprotective effects on knee OA. The present study compared the efficacy of oral NSAIDs, HA injection, and noninvasive ESWT for early OA of the knee. Forty-five patients with early knee OA were randomized into three groups. NSAIDs group received celecoxib 200 mg daily for 3 weeks. HA group received intra-articu

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Farpour, Hamid Reza, Fahime Estakhri, Mohadese Zakeri, and Reyhaneh Parvin. "Efficacy of Piroxicam Mesotherapy in Treatment of Knee Osteoarthritis: A Randomized Clinical Trial." Evidence-Based Complementary and Alternative Medicine 2020 (August 3, 2020): 1–8. http://dx.doi.org/10.1155/2020/6940741.

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Introduction. Knee osteoarthritis (KOA) is one of the most common degenerative diseases that lead to pain and disability. Oral NSAIDs are effective drugs used to alleviate symptoms in patients with KOA, but they have several important complications, especially in the elderly. In this study, we evaluated the effectiveness of mesotherapy on pain reduction and improvement of functioning in patients with KOA. Methods. Sixty-two patients with KOA, grade 2-3 of the Kellgren–Lawrence scale, were randomized into two groups: the mesotherapy group, in which two injections were applied with piroxicam at

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Kuznetsov, V. I. "Results of use of polyacrylamide gel Noltrexsin in patients with different grades of gonarthrosis in outpatient practice." Medical alphabet, no. 33 (December 13, 2021): 20–29. http://dx.doi.org/10.33667/2078-5631-2021-33-20-29.

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Introduction. Osteoarthritis of the knee joints is the most common joint disease affecting more than 80% of people over 55 years of age. The priority method for the treatment of gonarthrosis is the use of local injection therapy with the introduction of synovial ﬂuid endoprostheses based on hyaluronic acid, included in the Second Step of the ESCEO 2019 algorithm. Viscoelastic polyacrylamide gels for intra-articular administration since 2003 have also shown their high effciency in the symptomatic OA treatment. Since 2018, the new 3rd generation PAAG endoprosthesis of synovial ﬂuid, Noltrexsin,

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Shanawaz, Hussain, Kumar Shailesh, and K.R. Rajak Rajeev. "Comparison of Various Modalities in the Treatment of Early Knee Osteoarthritis." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 2148–51. https://doi.org/10.5281/zenodo.12771053.

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<strong>Background:</strong> Knee osteoarthritis (OA) is a prevalent degenerative joint disease, causing significant morbidity. Various treatment modalities, including pharmacological, non-pharmacological, and surgical options, are employed to manage early-stage knee OA. This retrospective study aims to compare the efficacy of these treatment modalities in alleviating symptoms and improving the quality of life in patients diagnosed with early knee OA. <strong>Materials and Methods:</strong> This study was conducted at the Department of Orthopedics, Government Medical College &am

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Sandeep, Nemiwal, and Bafna Garima. "EFFECT OF ACUPRESSURE VERSUS PHYSIOTHERAPY ON SYMPTOMS OF OSTEOARTHRITIS KNEE: A COMPARATIVE STUDY." International Journal of Basic & Applied Physiology 3, no. 1 (2014): 145–50. https://doi.org/10.5281/zenodo.4481764.

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<strong>Objectives</strong>: To determine the effect of acupressure and physiotherapy in reducing symptoms of osteoarthritis knee with comparison of the effectiveness of acupressure and physiotherapy. <strong>Methods</strong>: 60 Patients with symptomatic osteoarthritis of the knee were randomized to two treatment groups. Group one had acupressure and group second received physiotherapy. Patients in both groups were taking their stable dose of NSAIDs. Interventions: Patients receiving acupressure or physiotherapy were treated twice weekly over two months. Patients were assessed before treatmen

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Khuangsiriguk, Saradej, Mongkon Pisuttanawat, Danai Heebthamai, and Thanainit Chotanaphuti. "Effect of Transdermal Microneedle Patch Plus Nonsteroidal Anti-Inflammatory Drug in Knee Osteoarthritis: A Randomized, Double-Blind Study." Journal of Southeast Asian Orthopaedics 48, no. 1 (2024): 8–14. http://dx.doi.org/10.56929/jseaortho-2024-0192.

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Purpose: No recent clinical study has shown the efficacy of transdermal microneedle patch (TDM) plus nonsteroidal antiinflammatory drug (NSAID) in early knee osteoarthritis (OA). This study aimed to determine the effect of TDM plus NSAID on synovial hypertrophy, knee pain, and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score in osteoarthritic knees. Methods: A randomized, controlled, double-blind trial was conducted. One hundred participants, aged 40–70 years, with painful knee OA and radiographic nonstructural changes were randomly assigned into two groups to underg

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Svetlova, M. S. "Evaluation of the effectiveness of ketorolac or external use in the complex treatment of osteoarthritis of the knee joints." Meditsinskiy sovet = Medical Council, no. 3 (April 12, 2023): 156–60. http://dx.doi.org/10.21518/ms2023-073.

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Introduction. The problem of treatment of osteoarthritis (OA) remains relevant due to the high prevalence of the disease, the insecurity of drugs used by patients in the treatment of pain. The knee joints are most often affected. Chronic pain, impaired joint function significantly reduce the quality of life of patients, lead to the destabilization of concomitant diseases. In the complex therapy of OA, local remedies are widely used.Objective. To study the effectiveness of ketorolac for external use (KEU)in the complex therapy of osteoarthritis of the knee joints (OAKJ).Materials and methods. 5

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Svetlova, M. S. "Topical therapy with Meloxicam for external use (Amelotex gel) for knee osteoarthritis in elderly patients." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 3 (March 20, 2024): 45–52. http://dx.doi.org/10.33920/med-10-2403-05.

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Introduction. Treatment of osteoarthritis (OA) in elderly patients remains an urgent issue due to the high prevalence of the disease, as well as the unsafety of the used drugs (nonsteroidal anti-inflammatory drugs (NSAIDs)) and their effect on the concomitant pathology of an elderly patient. Knee joints are most often affected in OA. In the complex therapy of the disease, topical remedies (ointments, gels, and patches), which do not have pronounced side effects, are widely used. Purpose of the study: to evaluate the effectiveness of Meloxicam for external use (MEU) (Amelotex gel) in the comple

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Vas’kova, N. V., and O. M. Lesnyak. "COMPARATIVE EFFICACY OF INTRAARTICULAR THERAPY OF GONARTHROSIS WITH HYALURONIC ACID OF DIFFERENT MOLECULAR WEIGHT (A DOUBLE-BLIND RANDOMI7ED STUDY)." Osteoporosis and Bone Diseases 17, no. 2 (2014): 16–21. http://dx.doi.org/10.14341/osteo2014216-21.

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Objectives. To study the comparative efficacy and safety of intra-articular treatment of knee osteoarthritis (OA) with hyaluronic acid (HA) of different molecular weights (MW). Material and methods. Randomized double-blind controlled study included 50 patients with osteoarthritis of the knee stage II-III, weight-bearing pain more 40 mm on VAS and Lequesne index score > 4 and < 12. 25 patients received HA with MW 3500 kDa (Rusvisk group) and 25 patients were treated with HA with MW 1200-1400 kDa (Ostenil group) injected at 3-weekly intervals. During the 22-week observation period we asses

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Sivordova, L. E., J. V. Polyakova, E. V. Papichev, Y. R. Akhverdyan, and B. V. Zavodovsky. "Clinical efficiency and safety of innovative synovial fluid prosthesis in the treatment of gonarthritis." Meditsinskiy sovet = Medical Council, no. 21 (November 19, 2022): 127–36. http://dx.doi.org/10.21518/2079-701x-2022-16-21-127-136.

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Introduction. Scientific discussions about ways to improve the effectiveness and safety of osteoarthritis (OA) therapy do not stop. The article discusses the most controversial issues of the problem and presents the results of a study on the use of sodium hyaluronate in gonarthrosis.Aim. To compare the clinical efficacy, tolerability and safety of the use of synovial fluid substitute of domestic manufacture and symptomatic slow-acting drugs (SYSADOA) in patients with gonarthrosis. Study design. Prospective, comparative, randomized, single center study. The duration of the study was 12 months.M

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Karateev, A., E. Pogozheva, M. Sukhareva, and A. Lila. "AB0868 EFFICACY AND SAFETY OF PULSED ELECTROMAGNETIC FIELDS IN THE TREATMENT OF OSTEOARTHRITIS: RESULTS OF A MULTICENTER BLIND PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1740.2–1740. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3973.

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Background:Pulsed electromagnetic fields (PEMF) is a well – known method of non-pharmacological treatment that is widely used in knee osteoarthritis (KOA).Objectives:To evaluate the effectiveness and safety of PEMF in KOA.Methods:The study group consisted of 231 KOA patients, 77.9% of women, age 61.9±12.2 years, BMI 30.6±5.8 kg / m2, average disease duration 5.0 [2.0;10.0] years. Patients were randomly assigned to two groups. Group 1 patients received PEMF for 14 days using a device that creates a low-frequency pulsed magnetic field, group 2-a false PEMF (a device that completely simulates a w

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S, Tiwari. "Effectiveness of Siddha Varmam Therapy in Improving Pain, Flexibility and Quality of Life in Osteoarthritis Adults: A Randomized Controlled Study." Journal of Natural & Ayurvedic Medicine 8, no. 1 (2024): 1–5. http://dx.doi.org/10.23880/jonam-16000442.

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Background: Osteoarthritis (OA) is a prevalent degenerative joint disease-causing significant pain, stiffness, and functional disability. Current treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs), offer symptomatic relief but pose risks of adverse effects. Siddha Varmam therapy, a traditional Indian medical system, offers a non-invasive alternative focusing on pain management, flexibility enhancement, and quality of life improvement for the patients. Methods: This randomized control study involved 60 adults with OA, categorized 30 each into a control group receiving standard c

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JiaoYi, Pan, Sun YongQi, Guo KeChun, et al. "Assessing the efficacy and safety of different nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis: A systematic review and network meta-analysis based on RCT trials." PLOS One 20, no. 5 (2025): e0320379. https://doi.org/10.1371/journal.pone.0320379.

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Introduction Osteoarthritis (OA) as a degenerative disease, has seen a continuous rise in incidence and prevalence globally since 1990, imposing a significant disease burden. NSAIDs (Nonsteroidal anti-inflammatory drugs) as symptomatic medications for OA treatment, hold an indispensable position in clinical practice. Objective To evaluate the efficacy and safety of different NSAIDs in the treatment of OA through Bayesian Network Meta-Analysis (NMA). Methods Randomized controlled trials (RCTs) on NSAIDs for OA treatment were retrieved from PubMed, Web of Science, Embase, and the Cochrane Librar

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Letaeva, M. V., M. V. Koroleva, T. A. Raskina, O. S. Malyshenko, Yu V. Averkieva, and E. V. Usova. "Results of a prospective 6-year observational study of the efficacy and safety of a bioactive concentrate of small marine fish in senile patients with knee osteoarthritis and multimorbidity." Modern Rheumatology Journal 15, no. 4 (2021): 56–62. http://dx.doi.org/10.14412/1996-7012-2021-4-56-62.

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Objective: to evaluate the efficacy and safety of Alflutop therapy in elderly patients (75–90 years old) with knee osteoarthritis (OA) and multimorbidity based on the results of a prospective 6-year follow-up.Patients and methods. The study included 38 elderly women with knee OA (according to ACR criteria, 1986) stage II–III by Kellgren–Lawrence grading system, with pain ≥40 mm by visual analogue scale (VAS), who needed to take non-steroidal anti-inflammatory drugs (NSAIDs). Alflutop was administered as 1 ml intramuscular injections 20 consecutive days with a 6-month interval (12 courses). The

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Gouda, W. A., A. S. Abbas, T. M. Abdel-Aziz, M. Z. Shoaeir, A. Moshrif, and A. Mosallam. "POS1347 EVALUATING THE EFFICACY OF LOCAL CORTICOSTEROID INJECTION, PLATELET-RICH PLASMA, AND EXTRACORPOREAL SHOCKWAVE THERAPY IN PATIENTS WITH PES ANSERINE BURSITIS: A PILOT RANDOMIZED, COMPARATIVE CLINICAL TRIAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1024.2–1025. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4782.

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BackgroundPes anserine bursitis is one of the causes of painful knee syndromes. It limits physical activity and impairs the quality of life of a patient. Obesity and osteoarthritis (OA) of the knee are common predisposing factors for pes anserine bursitis. It is treated with non-steroidal anti-inflammatory drugs (NSAIDs), physiotherapy, injections of local anesthetics, and corticosteroids. This study examines the efficacy of local corticosteroid injection, Platelet-rich plasma (PRP) injection, and extracorporeal shock wave therapy (ESWT) as different modalities to alleviate pain and improve fu

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Kovalenko, P. S., I. S. Dydykina, E. S. Aronova, et al. "Treatment of knee joint osteoarthritis in overweight women in outpatient practice." Modern Rheumatology Journal 15, no. 4 (2021): 63–67. http://dx.doi.org/10.14412/1996-7012-2021-4-63-67.

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Objectives: evaluation of the clinical efficacy and safety of the healthy joints maintaining compound Artroflex® in knee osteoarthritis (OA) in postmenopausal overweight women in outpatient clinical practice.Patients and methods. An open, prospective observational single-center post-marketing study included 30 postmenopausal women 50–75 years old (mean age 62.3±6.3 years) with knee OA. Patient body mass index (BMI) was >25 (mean body weight 85.3±15.3 kg). Radiographically confirmed primary gonarthrosis stage II according to Kellgren–Lawrence was detected in 26 (87.0%) patients, stage III –

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Mazurov, V. I., A. G. Dorovskikh, and E. A. Trofimov. "Effect of systemic enzyme therapy on clinical manifestations of inflammation in gonarthrosis." HERALD of North-Western State Medical University named after I.I. Mechnikov 10, no. 2 (2018): 107–12. http://dx.doi.org/10.17816/mechnikov2018102107-112.

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Despite a significant number of studies on various schemes of OA therapy, there are only some studies with the use of systemic enzyme therapy (ETS) in combination with NSAIDs and / or SYSADOA. The aim was to study the effect of different groups of drugs (NSAIDs, ETS, SYSADOA) on the clinical course of gonarthrosis, as well as to develop an algorithm for the choice of treatment tactics depending on the clinical and sonographic manifestations of this disease. Methods. The data of 46 patients with stage I and stage II OA of Kellgren-Lawrence were analyzed. Patients of the first group received com

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Korzh, M. O., O. B. Iaremenko, A. S. Musiienko, et al. "Comparison of clinical efficacy and safety of original and generic forms of etoricoxib in patients with knee osteoarthritis." PAIN, JOINTS, SPINE 14, no. 1 (2024): 21–28. http://dx.doi.org/10.22141/pjs.14.1.2024.409.

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Background. Nonsteroidal anti-inflammatory drugs (NSAIDs) are an important drug class for the treatment of osteoarthritis (OA). Despite existing studies on the bioequivalence of original and generic NSAIDs, comparative studies related to their clinical efficacy and safety are limited. The purpose of the study was to compare the clinical efficacy and safety of the original and generic forms of etoricoxib in patients with knee OA. Materials and methods. In an open, comparative, randomized, multicenter study, 150 patients with knee OA were examined: group I — 50 persons who received the origina

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Lila, A. M., L. I. Alekseeva, E. A. Taskina, et al. "Olokizumab in patients with inflammatory phenotype of osteoarthritis, treatment experience." Modern Rheumatology Journal 18, no. 3 (2024): 14–24. http://dx.doi.org/10.14412/1996-7012-2024-3-14-24.

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Objective: to investigate the efficacy and safety of olokizumab (OKZ) in patients with knee osteoarthritis (OA) with synovitis, persistent pain and ineffectiveness of previous conservative therapy. Material and methods. The study included 15 patients with stage II–III knee OA who fulfilled the ACR criteria and had pain ≥50 mm on a visual analogue scale (VAS), synovitis and treatment failure. The age of patients ranged from 54 to 75 years; the duration of the disease was from 1 to 23 years. The duration of the study was 12 weeks, during which the patients received 3 subcutaneous injections of O

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Goncharova, V. E., and E. V. Zonova. "EFFECTIVENESS AND SAFETY OF CONCOMITANT USE OF PEPTIDE COMPLEX AND DIACEREIN IN OSTEOARTHRITIS OF KNEE JOINT." Sibirskij medicinskij vestnik 6, no. 1 (2022): 57–63. http://dx.doi.org/10.31549/2541-8289-2022-6-1-57-63.

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As part of a prospective study, it was evaluated the efficacy and safety of the combined use of drugs from the group of symptomatic slow acting agents (SYSADOA): Diacerein and glycosaminoglycan peptide complex (GPC) in patients with knee osteoarthritis. The dynamics of pain according to Visual Analoguе Scale (VAS), need for non-steroidal anti-inflammatory drugs, the WOMAC index, EQ-5D score, and OMERACT-OARSI criterion, the presence of adverse events were analyzed, and the effect of Diacerein on the components of the metabolic syndrome was assessed. It was shown that the concomitant use of GPC

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Shafieva, I. A., S. V. Bulgakova, A. V. Shafieva, and D. P. Kurmayev. "Evaluation of the efficacy and safety of various non-steroidal anti-inflammatory drugs in postmenopausal women with an inflammatory phenotype of osteoarthritis." Meditsinskiy sovet = Medical Council, no. 15 (October 20, 2023): 104–10. http://dx.doi.org/10.21518/ms2023-281.

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Introduction. Non-steroidal anti-inflammatory drugs (NSAIDs) are currently the mainstay of the management for relieving pain syndrome in osteoarthritis (OA). NSAIDs are characterized by an individual reaction to medication, as well as a quite high frequency of gastrointestinal side effects. The issue of the disadvantages and advantages of a particular group of NSAIDs is still open.Aim. To evaluate the safety and efficacy of Meloxicam at a dose of 15 mg/day as compared with Nimesulide and placebo in postmenopausal women with an inflammatory phenotype of OA.Results and discussion. The frequency

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Mortada, M. A., L. I. Kotb, and Y. A. Amer. "Impact of ultrasonography detected quadriceps calcific tendinopathy on pain and function in patients with primary knee osteoarthritis." Reumatismo 73, no. 2 (2021): 111–16. http://dx.doi.org/10.4081/reumatismo.2021.1381.

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Calcific tendinopathy is most commonly seen around the shoulder joint. Only a few cases of quadriceps calcific tendinopathy (QCT) were reported. This study compares pain, function, clinical examination results, and ultrasonographic findings among primary knee osteoarthritis (KOA) patients with or without ultrasonography-detected QCT. A cross-sectional study was conducted on 214 patients with knee OA. Ultrasonography (US) of knee joints was performed according to the EULAR guidelines. Kellgren-Lawrence radiographic grading was used to score OA. Pain and functional status were assessed using the

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Varadi, Dr Gyula. "Randomized Clinical Trial Evaluating Transdermal Ibuprofen for Moderate to Severe Knee Osteoarthritis." Pain Physician 6;16, no. 6;11 (2013): E749—E762. http://dx.doi.org/10.36076/ppj.2013/16/e749.

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Background: Osteoarthritis is a common condition, typically treated with orally administered analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). Chronic administration of NSAIDs, serotoninnorepinephrine reuptake inhibitors (SNRIs, i.e., duloxetine), and opioid medications (i.e., tramadole) is regularly associated with multiple, serious side effects, in part due to the route of administration. Transdermal delivery of NSAIDs, such as ibuprofen, represents a potentially alternative treatment for this inflammatory pain condition with a better therapeutic profile. Objective: Investigate

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Kovalenko, P. S., I. S. Dydykina, O. G. Alekseeva, et al. "Evaluation of the impact of a course of therapy with an injectable form of chondroitin sulfate on the duration of remission and quality of life in patients with osteoarthritis." Modern Rheumatology Journal 17, no. 6 (2023): 84–91. http://dx.doi.org/10.14412/1996-7012-2023-6-84-91.

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Ensuring a long-lasting effect of the therapy and its safety are important tasks in the treatment of patients with osteoarthritis (OA). Parenteral forms of chondroitin sulfate (CS) used for the background therapy of OA are characterized by proven efficacy and safety and, compared to oral forms, have greater bioavailability, faster onset of symptom-modifying effect and maintenance of more stable remission, which can significantly improve patients' quality of life.Objective: to evaluate the clinical efficacy and safety of two-month therapy with injectable CS and the duration of positive dynamics

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Raskina, T., J. Averkieva, M. Letaeva, O. Malyshenko, and M. Koroleva. "AB0983 RESULTS OF A PROSPECTIVE 6-YEAR OBSERVATIONAL STUDY OF THE EFFICACY AND SAFETY OF A BIOACTIVE CONCENTRATE OF SMALL MARINE FISH IN SENILE PATIENTS WITH KNEE OSTEOARTHRITIS AND MULTIMORBIDITY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1617.3–1618. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2550.

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BackgroundAccording to the updated ESCEO, 2019 guidelines for the management of the knee osteoarthritis (OA), SYSADOA, which includes bioactive concentrate small sea fish (BCSSF), is a mandatory component of OA therapy. There are few studies evaluating the efficacy and safety of BCSSF in elderly patients with knee OA and a high level of multimorbidity, which served as the basis for this work.ObjectivesTo evaluate the efficacy and safety of BCSSF therapy in elderly patients (75–90 years old) with knee osteoarthritis (OA) and multimorbidity based on the results of a prospective 6-year follow-up.

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Arkhipova, A., N. Zhuravleva, E. Guryanova та V. Diomidova. "AB1493 REHABILITATION OF PATIENTS WITH ОSTEOARTHRITIS OF THE KNEE USING MAGNETIC THERAPY". Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1850.3–1851. http://dx.doi.org/10.1136/annrheumdis-2022-eular.583.

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BackgroundCurrently, along with the basic treatment at the outpatient stage of rehabilitation, methods using physical and balneological factors are successfully applied: magnetotherapy, electrotherapy, peloidtherapy.ObjectivesEvaluation of the effectiveness of rehabilitation using magnetotherapy for osteoarthritis of the knee joints at the second radiological stage.MethodsThe study included 75 patients with primary osteoarthritis of the knee joints of the II X-ray stage, who were on outpatient rehabilitation in the sanatorium “Chuvashiyakurort”, including 45 women and 30 men aged 50 to 65 year

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Đoàn, Thị Len, та Thị Như Quỳnh Trần. "Kết quả tiêm nội khớp acid hyaluronic trọng lượng phân tử cao trong điều trị thoái hóa khớp gối nguyên phát ở bệnh nhân đái tháo đường típ 2". Vietnam Journal of Diabetes and Endocrinology, № 68 (13 червня 2024): 59–61. http://dx.doi.org/10.47122/vjde.2023.68.9.

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Mục tiêu: Đánh giá kết quả và tác dụng không mong muốn của acid hyaluronic trọng lượng phân tử cao (HA TLPT cao) tiêm nội khớp trong điều trị thoái hóa khớp gối (THKG) nguyên phát ở bệnh nhân (BN) đái tháo đường (ĐTĐ) típ 2. Đối tượng và phương pháp: Nghiên cứu tiến cứu, can thiệp, theo dõi dọc 46 BN ĐTĐ típ 2 (68 khớp gối thoái hóa), chẩn đoán THKG nguyên phát theo tiêu chuẩn ACR 2016, phân loại XQ giai đoạn II, III theo Kellgren và Lawrence, ĐTĐ tip2 theo tiêu chuẩn ADA 2021, BN thất bại với điều trị nền (sử dụng các thuốc chống thoái hóa khớp tác dụng chậm SYSADOA trên 3 tháng + chống viêm

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Bessarab, M. S., G. O. Krasnov, A. M. Charchyan, and S. N. Khoroshkov. "Comparative analysis of the arthroscopy efficacy and complex therapy in the treatment of degenerative meniscal tears in patients with knee osteoarthritis." Russian Medical Inquiry 5, no. 2 (2021): 71–77. http://dx.doi.org/10.32364/2587-6821-2021-5-2-71-77.

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Aim: to evaluate the efficacy of conservative treatment in patients with degenerative meniscal tear (DMT) in the setting of knee osteoarthritis (OA) as an alternative to combined treatment. Patients and Methods: a prospective comparative study included 236 patients aged 45–65 years with DMT in the setting of stage I–III OA according to the Kellgren-Lawrence classification (70 of them — men). Group 1 consisted of 122 patients (86 of them — women) who underwent combined treatment: arthroscopy for DMT of the knee joint and complex therapy in the postoperative period: NSAIDs (celecoxib), a combine

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Gajare, Dr Umesh, Dr Gayatri Ganu, Dr Dheeraj Nagore, and Ashish Nagoakar. "A parallel arm interventional clinical Study to assess the efficacy and tolerability of ointment with natural ingredient in patients with chronic osteoarthritis of knee and low back ache." Journal of Innovations in Pharmaceutical and Biological Sciences 09, no. 03 (2022): 06–11. http://dx.doi.org/10.56511/jipbs.2022.9302.

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Background: Treatment of OA focuses on reducing symptoms. Such treatment can be analgesic or nonsteroidal anti-inflammatory agents. With the current frequency and severity of adverse effects from analgesics and NSAIDs, suggestions for safer and sustainable interventions to manage the pain and stiffness are warranted. Natural local remedies, because of their relative safety, may reduce dependency on NSAIDs and analgesics and could have an important role in the treatment of OA. Trial design: Trial was parallel arm involving 60 patients with chronic osteoarthritis of knee and low back ache includ

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Hasan, Md Firoze, Muhammad Alamgir Mandal, Md Afzalur Rahman, et al. "Effect of Ultrasound Therapy on Patients With Osteoarthritis of The Knee Joint." KYAMC Journal 7, no. 2 (2017): 750–57. http://dx.doi.org/10.3329/kyamcj.v7i2.33828.

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Background: Osteoarthritis (OA) is the most common form of arthritis accounting for about 30% of general physician visits. Objectives: To detect the effects of ultrasound therapy on patients with osteoarthritis of the knee joint.Methodology: It was a prospective non randomized clinical study, conducted in the Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka during the periods of 1st March, 2012 to 31st August, 2012. Fifty four patients between 35-75 years of age without consideration of gender with a history of not less than three

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Sudheer, Urampath, and Chundarathil Jayaprakash. "Clinical outcome of intra-articular hyaluronic acid injection for knee joint osteoarthritis: a prospective interventional study from a tertiary care hospital." International Journal of Research in Orthopaedics 3, no. 3 (2017): 595. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20171908.

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<p><strong>Background:</strong> The prevalence of knee osteoarthritis (OA) is estimated to be 14%<strong> </strong>and 6% in rural and<strong> </strong>urban areas of India, respectively. In severe cases, the American Academy of Orthopedics Surgeons recommends non-steroidal anti-inflammatory drugs (NSAIDs). A prospective interventional study was conducted to evaluate the effectiveness of intra-articlular hyaluronic acid injection (IAHA) in knee OA patients.</p><p><strong>Methods:</strong> Medical records of 29 patients with knee

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Filatova, E., L. Alekseeva, E. Taskina, N. Kashevarova, A. Lila, and E. Sharapova. "AB0599 EFFICACY AND SAFETY OF COMBINATION THERAPY WITH NSAIDS AND ANTICONVULSANT, COMPARED WITH NSAID MONOTHERAPY FOR CHRONIC PAIN IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE JOINTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1336.1–1336. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3062.

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Background:In 20-44% of patients with osteoarthritis of the knee joints neuroplastic changes occur due to central sensitization (1,2), which is the rationale for complex therapy, including centrally acting drugs, for more effective pain control.Objectives:To evaluate the efficacy and safety of combination therapy with NSAID and anticonvulsant in comparison with NSAID monotherapy in patients with osteoarthritis of the knee joints and signs of central sensitization or nocyplastic painMethods:The study included 60 women with osteoarthritis of the knee joints (OAK) with signs of nocyplastic pain.

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Iordan, Daniel-Andrei, Ilie Onu, Daniela-Viorelia Matei, et al. "Effect of hydrocortisone ultrasonic phonophoresis in the treatment of knee osteoarthritis." Balneo and PRM Research Journal, Vol.14, no.3 (September 1, 2023): 575. http://dx.doi.org/10.12680/balneo.2023.575.

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Background: Knee Osteoarthritis (KOA) is a frequent type of degenerative joint disease, which results in a gradual loss of function, discomfort, and stiffness. KOA can be effectively treated with oral drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may raise the dangers of renal, gastrointestinal, and other systemic toxicities. Compared with oral NSAIDs, topical gels are an alternative therapeutic option with fewer side effects, with less therapeutic efficacy. Studies on ultrasound (US) as a therapeutic method go back a long time in KOA. US not only reli

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Dnyaneshwar Mote. "Evaluation of efficacy of topical herbal analgesic Arthrella Ointment in Osteoarthritic Patients." Journal of Ayurveda and Integrated Medical Sciences 9, no. 3 (2024): 01–05. http://dx.doi.org/10.21760/jaims.9.3.1.

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Osteoarthritis (OA) is a chronic condition involving degradation of cartilage within the joints mostly found in Elderly population causing immense pain and disability in Patients, NSAIDs are the first line of drug in conventional medicine to manage pain. But it leads to Gastrointestinal, Cardiovascular, Renal and other systemic AEs. Arthrella Ointment being a Topical-Herbal ointment has no reported side effects and AEs. Thus, a safe treatment option to alleviate pain in OA Patients. In this Clinical study 87 Subjects with OA were divided in two groups, one was treated with Arthrella Ointment f

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Lila, A. M., E. A. Taskina, L. I. Alekseeva, et al. "A prospective study on the effects of glucosamine hydrochloride and chondroitin sulfate combination on systemic inflammation markers in patients with knee osteoarthritis (report 1)." Modern Rheumatology Journal 19, no. 3 (2025): 94–102. https://doi.org/10.14412/1996-7012-2025-3-94-102.

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Objective: to assess the effect of a combination of glucosamine hydrochloride (GH) 500 mg and chondroitin sulfate (CS) 500 mg (Artra®) on systemic inflammation markers in patients with knee osteoarthritis (KOA).Material and methods. The study included 70 patients with a confirmed diagnosis of KOA stage II–III and walking pain ≥4 points on a numerical rating scale (NRS). Study duration was 3 months. All patients received Artra® and, if necessary, topical nonsteroidal anti-inflammatory drugs (NSAIDs). Treatment efficacy was evaluated by changes in pain according to NRS, the WOMAC index, and pati

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Naumov, Anton V., Aleksey V. Unkovskiy, Natalia O. Khovasova, Danila K. Fokeev, and Anastasia V. Kolesnikova. "Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations." Terapevticheskii arkhiv 97, no. 5 (2025): 419–26. https://doi.org/10.26442/00403660.2025.05.203272.

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Aim. To evaluate the efficacy of a combination therapy containing chondroitin sulfate (CS), glucosamine (GL), methylsulfonylmethane (MSM), hyaluronic acid (HA), and native/hydrolyzed collagen compared to collagen-free therapy in the initial management of knee osteoarthritis (OA) exacerbations. Materials and methods. A single-center, prospective, comparative phase IV study included 60 patients with knee OA (Kellgren–Lawrence stages 2–3). Participants were randomized into two groups: Group A (n=30) received CS/GL/MSM/HA, while Group B (n=30) received the same regimen supplemented with collagen.

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