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Rozprawy doktorskie na temat „Nutritional Target”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Truchan, Hilary Kay. "Anaplasma phagocytophilum nutritional virulence mechanisms target the host cell secretory pathway." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3620.

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Obligate intracellular pathogens must acquire host cell-derived nutrients to facilitate their survival. One such bacterial pathogen, Anaplasma phagocytophilum, replicates within neutrophils and non-phagocytic cells in a bacterial-modified, host cell-derived vacuole. The bacterium exploits host cell vesicular trafficking pathways to route nutrients to its vacuole and utilizes Rab GTPases, guanine nucleotide-dependent, vesicular trafficking regulators, to do so. We previously discovered that the A. phagocytophilum vacuolar membrane is decorated with a specific subset of Rab GTPases - Rab1, Rab4A

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Jariwala, Nidhi H. "Characterization of Staphylococcal nuclease and tudor domain containing protein 1 (SND1) as a molecular target in Hepatocellular carcinoma and Non-alcoholic steatohepatitis." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5183.

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CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS Nidhi Jariwala, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences Virginia Commonwealth University, 2017 Devanand Sarkar, M.B.B.S., PhD. Associate Professor, Department of Human and Molecular Genetics Virginia Commonwealth University Richmond, Virginia SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an onco

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Wilkinson, Thomas James. "Rheumatoid cachexia in rheumatoid arthritis patients treated in the current treat-to-target era : an exploration of the incidence, mechanisms, effects on physical function, and a potential nutritional treatment." Thesis, Bangor University, 2016. https://research.bangor.ac.uk/portal/en/theses/rheumatoid-cachexia-in-rheumatoid-arthritis-patients-treated-in-the-current-treattotarget-era-an-exploration-of-the-incidence-mechanisms-effects-on-physical-function-and-a-potential-nutritional-treatment(5eeafa02-5a7f-49d6-ae43-4ee4aeb7f9c5).html.

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Rheumatoid cachexia (RC), i.e. muscle wasting and adiposity gain in rheumatoid arthritis (RA), is driven by inflammation and is a major contributor to reduced strength and physical function. Current treatment for RA is based on approaches that aim to tightly control inflammation from diagnosis onwards. This is best exemplified by ‘treat-to-target’ (T2T), which targets low disease activity, preferably ‘clinical remission’. The success of T2T in controlling inflammation is well-established, but whether it has attenuated RC is unknown. In a cross-sectional trial, we demonstrated that, despite wel

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Thondamal, Manjunatha. "Molecular links between nutrition, reproduction and aging." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0953/document.

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Une restriction alimentaire améliore la qualité du vieillissement et augmente la durée de vie chez de nombreuses espèces, y compris certains primates. Cependant, cette intervention s'accompagne souvent d'une baisse significative des capacités reproductives. Il est donc légitime de se demander si des signaux provenant du système reproductif contribuent aux effets positifs de la restriction alimentaire sur la longévité. Durant ma thèse, j'ai montré que l'expression de DAF-9/CYP27A1 et la production de l'hormone stéroïdienne D7- acide dafachronique (DA) sont augmentées chez C. elegans lorsque les

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Penner, Johan. "Foliar nutrition: targeted fertilization to test herbivore preference." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94349.

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Abstract The aim of this study was to increase knowledge of how plants as a whole respond to targeted fertilization and to refine the method of foliar nutrition fertilization. The experiment also aimed to test how herbivores respond when presented with a choice between fertilized and unfertilized Salix leaves in a feeding trial experiment. One major problem that arises when trying to alter the nutrient levels within a specific part of a plant is that adding fertilizer directly to the soil in which the plants grow will have a systemic effect on the plant, causing the plant physiology as a who

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Gonzalez, Gabriela Rae. "Contaminants at a Shooting Range: Toxicological and Nutritional Significance to Birds and Mammals." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/34629.

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Target shooting in the United States has become an increasingly popular sport in the last century. In addition to the large quantity of lead pellets littering range grounds and surrounding land, considerable amounts of clay target fragments cover shooting range areas as well as adjoining habitats. Polycyclic aromatic hydrocarbons (PAHs) within the target, as well as lead pellets from shotguns pose multiple threats to a variety of wildlife. To determine the effects of clay target and lead pellet ingestion on wildlife, I conducted controlled experiments on Coturnix quail exposed to clay targets

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Feng, Shiyun. "Investigating novel direct Notch targets in Drosophila neural stem cells." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276692.

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Notch signalling is an evolutionary highly conserved signalling pathway. It plays various important roles in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development. Notch signalling has a simple transduction pathway. Upon Notch ligand binding to the receptor, the Notch intracellular domain (NICD) is released into the nucleus. The nuclear NICD interacts with the DNA-binding protein Suppressor of Hairless (Su(H)) to activate the expression of target genes, which are silenced by the Su(H)-corepr

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8

Casey, Erin M. "UTILIZATION OF WEB‐BASED APP TO TARGET OBESOGENIC FACTORS IN RURAL KENTUCKY COUNTIES WITH HIGH RATES OF OBESITY." UKnowledge, 2018. https://uknowledge.uky.edu/foodsci_etds/60.

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Due to socioeconomic disparities and geographic isolation, rural Kentucky residents bear a greater burden of poor health compared to national averages. Specifically, rural Kentucky residents are at greater risk of becoming obese and suffering from comorbidities of obesity such as type 2 diabetes, hypertension and cardiovascular disease. The purpose of the present study was two-fold. First, we the barriers to nutrition and physical activity unique to rural Kentucky counties which high proportions of obese adults (< 40%) were examined and extrapolated. Second, this information was used to develo

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Alemdaroglu, N. Ceren. "Impact of folate absorption and transport for nutrition and drug targeting." Saarbrücken VDM Verlag Dr. Müller, 2004. http://d-nb.info/991372220/04.

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Adelman, Sarah. "Early childhood nutritional responses to targeted food aid and social network disruptions in Ugandan internally displaced person's camps." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9481.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Dept. of Agricultural and Resource Economics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Morgan-Bathke, Maria Elizabeth. "The Role of Autophagy in Salivary Gland Dysfunction Following Targeted Head and Neck Radiation." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301532.

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Head and neck cancer is one of the most common cancers worldwide. The current standard of care for head and neck cancer includes surgical resection of the tumor followed by chemoradiation. This targeted head and neck radiation causes dysfunction of the salivary glands, which leads to xerostomia, mucositis, dysphagia, dental caries, and malnutrition. These side effects greatly decrease patient quality of life and increase their financial responsibility. Current therapies available to ameliorate these negative side effects are expensive, only provide short-term relief, and many of them have nega

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12

Picchioni, Mary J. "Targeted Oral L-Glutamine Treatment of Grades 1, 2, and 3 Oral Mucositis in Adults with Diagnosed Primary Gastrointestinal Malignancy Receiving 5-Fluorouracil (5-FU): A Feasibility Pilot Study." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194338.

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PurposeThe purpose of this pilot study was to explore nutritional injury in the context of oral mucositis (OM). It was a beginning look at oral L-glutamine (L-Gln) treatment efficacy through investigation of three "Reaction-to-Nutritional Injury" hypotheses defining OM as a localized secondary nutritional disorder of deficiency (Van Itallie, 1977) resulting from absence of/limited nutritional collateral systems (Kight, 1994):(1) OM severity and human buccal epithelial cell glutamine synthetase (HBEC GS) abundance,(2) HBEC GS abundance and L-Gln treatment, and(3) OM severity and L-Gln treat

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Fanzo, Jessica Christine. "The influence of zinc status onp53 tumor suppressor gene expression and p53 target genes in human hepatoblastoma, bronchial epithelial, and aortic endothelial cells." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289149.

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The influence of zinc status on the expression of p53, the human tumor suppressor gene as well as downstream target genes of p53 were examined in human cell lines. HepG2 cells were depleted of cellular zinc using a low-zinc media containing Chelex-100 treated serum. Cellular zinc levels were depleted to 64% of controls (4.0 μM zinc, comparable to normal media). p53 mRNA was increased in the zinc-depleted HepG2s as compared to control, however, p53 protein levels and DNA binding activity were not significantly different among treatment groups. NHBEs were depleted of zinc using a serum-free zinc

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14

Cichon, Morgan Julienne. "Investigating the Role of Tomato Phytochemicals through Targeted and Untargeted Metabolomics." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449226913.

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Joo, Woojin. "Effectiveness and safety of early enteral nutrition for patients who received targeted temperature management after out-of-hospital cardiac arrest." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263529.

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Hammond, Gail Kathleen. "Midlife women, food choice, and bone health : a qualitative case study of using a participatory practice approach to develop targeted nutrition education resources." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/28118.

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Nutrition professionals rely on nutrition education resources to help people make informed food choices. Despite this reliance, nutrition education resources are often developed in isolation of the intended users, a practice that may compromise the effectiveness of dietary services provided by nutrition professionals. Diet is a modifiable factor impacting bone health. Concurrent with midlife Canadian women’s less than recommended dietary intake of foods rich in calcium and vitamin D—two key nutrients for bone health—is a projected increased incidence of osteoporosis as Canada’s population ages

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Simoens, Christian. "Intravascular metabolism of lipid emulsions with different fatty acid pattern: influence on fatty acid profile of membrane phospholipids in target organs and cells." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209776.

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De, Souza Silveira Raul [Verfasser], and Frank [Akademischer Betreuer] Mayer. "Human substrate metabolism at upper oxidative capacities : how intensity and pre-exercise nutrition affect the oxidative regulation of carbohydrate and fat during metabolic targeted running / Raul de Souza Silveira ; Betreuer: Frank Mayer." Potsdam : Universität Potsdam, 2017. http://d-nb.info/1218404329/34.

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de, Souza Silveira Raul [Verfasser], and Frank [Akademischer Betreuer] Mayer. "Human substrate metabolism at upper oxidative capacities : how intensity and pre-exercise nutrition affect the oxidative regulation of carbohydrate and fat during metabolic targeted running / Raul de Souza Silveira ; Betreuer: Frank Mayer." Potsdam : Universität Potsdam, 2017. http://d-nb.info/1218404329/34.

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Connell, Mary J. "Determination of the Total Dietary Polyphenol Load of a Population of Healthy Adults in Appalachia, Ohio." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1618492915308894.

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Racicot, Riccardo. "One-Carbon Metabolism Related B-Vitamins Alter The Expression Of MicroRNAS And Target Genes Within The Wnt Signaling Pathway In Mouse Colonic Epithelium." 2016. https://scholarworks.umass.edu/masters_theses_2/372.

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ABSTRACT It has been widely recognized that microRNAs are involved in nearly all cellular processes that have been investigated and contribute to a variety of diseases including cancer. Our prior studies demonstrated the depletion of one-carbon metabolism related B-vitamins, including folate, vitamin B2, B6 and B12, induced a genomic DNA hypomethylation and an elevation of the tumorigenic Wnt signaling in mouse colonic epithelium. The present study aimed to define whether microRNAs serve as mediators between these B-vitamins and the Wnt signaling, and thereby influence intestinal tumorigenesis

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Lapa, Maria de Fátima Kilberg. "Desenvolvimento de uma linha de gelados para grupos alvo específicos." Master's thesis, 2019. http://hdl.handle.net/10400.14/31712.

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Este trabalho teve como objetivo global a criação de novos produtos que permitam ir de encontro das necessidades de consumidores específicos. O projeto foi realizado num contexto empresarial, numa produção de gelados artesanais e consistiu no desenvolvimento de um Gelado Tradicional de Chocolate que, por não conter glúten, é apto para o grupo específico de celíacos, um Sorvete sem Sacarose de Limão, apto para diabéticos, um Sorvete Enriquecido em Mirtilo, adequado para os consumidores intolerantes à lactose, e de um Gelado Fonte de Proteína de Kefir, um Gelado Fonte de Proteína de Skyr e um Ge

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Omand, Jessica Ann. "Predictors of 25-hydroxyvitamin D Serum Concentrations among Non-western Immigrant Preschool Children." Thesis, 2013. http://hdl.handle.net/1807/35132.

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We determined whether children older than 1 year from non-western immigrant families had lower serum 25-hydroxyvitamin D levels than children from western born families. Children ages 1-6 years were recruited through the TARGet Kids! practice based research network. Univariable analysis revealed that non-western immigrant children had 4 nmol/L lower 25-hydroxyvitamin D (p=0.006; 95% CI:1.4-8.0) and increased odds of 25-hydroxyvitamin D <50 nmol/L (OR 1.9, 95% CI:1.3–2.9). After adjustment for known vitamin D determinants, cow’s milk intake, vitamin D supplements, season and age were significan

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Rumala, Courtney. "Metabolic regulation of insulin secretion: the link between excess glucose, mechanistic target of rapamycin complex 1 & hyperinsulinemia." Thesis, 2019. https://hdl.handle.net/2144/38590.

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Obesity, a major risk factor in the development of Type 2 Diabetes (T2D), is commonly associated with insulin resistance and hyperinsulinemia. The long accepted view has been that insulin resistance drives hyperinsulinemia; however, there are multiple lines of evidence that hyperinsulinemia can precede and drive insulin resistance. The signals and mechanisms by which chronic excess nutrients promote pancreatic β-cell dysfunction remain poorly understood. This prompted us to define the signaling events that contribute to basal insulin hypersecretion induced by excess glucose. Of particula

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"Targeted Metabolomics Reveals the Effect of Nitrate Supplementation on Vascular Function." Master's thesis, 2020. http://hdl.handle.net/2286/R.I.62984.

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abstract: In the United States, two-thirds of adults are considered hypertensive orprehypertensive. In addition, chronic illness, such as hypertension, cardiovascular disease, and type II diabetes, results in $3.5 trillion in annual healthcare cost and is the primary cause of disability and death. As a result, many individuals seek cheaper and simpler alternatives to combat their conditions. In this exploratory analysis, a study assessing nitrate intake and its effects on vascular function in 39 young adult males was investigated for underlying metabolic variations through a liquid chromatogra

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Costa, João Pedro Albuquerque e. "From mouth to mammary gland: a nanotechnology application in dairy cow nutrition for targeted lysine delivery." Doctoral thesis, 2020. https://hdl.handle.net/10216/129175.

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Costa, João Pedro Albuquerque e. "From mouth to mammary gland: a nanotechnology application in dairy cow nutrition for targeted lysine delivery." Tese, 2020. https://hdl.handle.net/10216/129175.

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Hurley, Brenden A. "MAKING SURE HUNGRY PLANTS GET FED: THE DUAL-TARGETED PURPLE ACID PHOSPHATASE ISOZYME AtPAP26 IS ESSENTIAL FOR EFFICIENT ACCLIMATION OF ARABIDOPSIS THALIANA TO NUTRITIONAL PHOSPHATE DEPRIVATION." Thesis, 2009. http://hdl.handle.net/1974/5325.

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Acid phosphatases (APases; E.C. 3.1.3.2) catalyze the hydrolysis of phosphate (Pi) from Pi monoesters and anhydrides within the acidic pH range. Induction of intracellular and secreted purple acid phosphatases (PAPs) is a widespread plant response to nutritional Pi-deficiency. The probable function of intracellular APases is to recycle Pi from expendable intracellular organophosphate pools, whereas secreted APases likely scavenge Pi from the organically bound Pi that is prevalent in most soils. Although the catalytic function and regulation of plant PAPs have been described, their physiologica

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