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Artykuły w czasopismach na temat „Ocular oncology and case report”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Nixon, Nisha, Vaidehi Konteti, Karan Gupta, Anna Thompson, Erika Damato, and Madhavan Rajan. "Severe Ocular Adverse Reaction Following Single Pembrolizumab Infusion: A Case Report." Clinics of oncology 07, no. 12 (2024): 01–04. http://dx.doi.org/10.47829/coo.2024.71201.

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1.1. Purpose: To report a case of severe sight loss following single infusion of pembrolzumab 1.2. Methods: Retrospective case report 1.3. Results: Ocular adverse events associated with immune checkpoint inhibitors, due to their rarity, remain poorly characterised. Pembrolizumab targets the programmed cell death (PD-1) protein on T cells, circumventing the mechanisms by which cancer cells evade the body’s adaptive immune response. To date, reports of ocular surface disease, neuro-ophthalmic complications, orbitopathy, retinal dysfunction and uveitis have been reported following pembrolizumab i

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2

F, Guido. "Bilateral Sclerochoroidal Calcifications: A Case Report." Open Access Journal of Ophthalmology 8, no. 1 (2023): 1–5. http://dx.doi.org/10.23880/oajo-16000278.

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Purpose: The aim of this case report is to describe a rare condition of bilateral sclerochoroidal calcification Case Report: A 79 years old asymptomatic Caucasian female was referred to our Ocular Oncology Center of the Ophthalmic Surgery Department of Pisa on November 2021. She was in apparent good health. Funduscopic examination revealed yellowwhite irregular lesions in the supero-temporal quadrant of both eyes. Best-corrected visual acuity was 20/20. B-scan and A-scan ultrasound revealed hyper-echoic solid lesions with acoustic orbital shadowing measuring 1.5 mm in thickness and 4.6 mm in d

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Blanchard, Sierra, Suzzane Li, and Danielle Weiler. "Erdafitinib-associated Central Serous Chorioretinopathy: A Case Report." Canadian Journal of Optometry 84, no. 4 (2022): 35–40. http://dx.doi.org/10.15353/cjo.v84i4.4349.

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Erdafitinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor approved to treat patients with metastatic or advanced urothelial carcinoma and is being developed for the treatment of other cancer types. This oral chemotherapeutic agent carries a warning for potential ocular adverse reactions including central serous chorioretinopathy and dry eyes. This case report describes an 88-year-old Caucasian male co-managed in the eye clinic over the course of treatment with erdafitinib for metastatic urothelial carcinoma. The patient developed asymptomatic episodes of recurring and remi

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Czyz, Craig, Kyle Blair, and Reece Bergstrom. "Leptomeningeal Carcinomatosis with Delayed Ocular Manifestations." Case Reports in Oncology 14, no. 1 (2021): 98–100. http://dx.doi.org/10.1159/000510808.

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The most common presenting symptoms of leptomeningeal carcinomatosis (LC) are ocular manifestations with vision loss. There are multiple reports of undiagnosed LC causing sudden, complete, monocular vision loss as the presenting symptom; however, sudden bilateral vision loss 6 months following diagnosis has not been described. Any new ocular involvement or worsening of previous ocular symptoms warrants reimaging and prompt ophthalmology consultation, as this likely indicates disease progression. This report details a unique case of LC where a previously diagnosed patient developed sudden, comp

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5

Patidar, Yaman, Smitha C. Saldhana, M. C. Suresh Babu, et al. "Symptomatic orbital metastasis as an initial presentation of adenocarcinoma lung: A case report and review of literature." Lung India 41, no. 5 (2024): 375–78. http://dx.doi.org/10.4103/lungindia.lungindia_60_24.

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ABSTRACT Orbital metastasis is a rare entity in oncology. With increasing awareness and advancement, patients with initial ocular presentation can be diagnosed and treated. Ocular metastasis is more common in breast cancer followed by lung cancer. Lung cancer with ocular presentation generally have poor prognosis because of difficult diagnosis, Vision impairment and delayed management. Here, we report one such case of 59 year old female presented with painful periorbital swelling in left eye for 3 months with no pulmonary symptoms. On evaluation, she was diagnosed as ocular metastasis with pri

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Bhattarai, Sarita, Susmina Maharjan, Reeya Shah, and Anju Shrestha. "A Case of Leukemic Retinopathy." International Journal of Silkroad Institute of Research and Training 2, no. 2 (2024): 115–17. https://doi.org/10.3126/ijsirt.v2i2.74374.

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This case report describes a 4-year-old male with a known history of acute leukemia, presenting with blurred vision in both eyes following chemotherapy. On examination, the child exhibited central, steady, and maintained vision, with findings suggestive of leukemic retinopathy, including scattered retinal infiltration, vitreous cells, and exudative retinal detachment in both eyes. Leukemic retinopathy, a rare ocular manifestation of leukemia, often arises from the direct infiltration of leukemic cells and is more commonly seen in acute leukemia. Ocular involvement, which may include retinal he

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Colaço, Raul, Mariana Portela, Ilda Costa, Marta Guedes, and António Mota. "Radiotherapy as Salvage Treatment in Intraocular Lymphoma: A Case Report." Case Reports in Oncology 14, no. 1 (2021): 184–89. http://dx.doi.org/10.1159/000512216.

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A 67-year-old previously healthy woman presented with progressive visual impairment including bitemporal hemianopsia. A brain magnetic resonance imaging revealed a contrast-enhancing mass in the optic chiasm, spreading along the left optic tract. The patient underwent a transcranial biopsy of the left optical tract that yielded a diagnosis of diffuse large B-cell lymphoma. CT scans of the chest, abdomen, and pelvis, PET-CT, and bone marrow biopsy revealed no evidence of systemic lymphoma. Thus, the final diagnosis was of primary central nervous system lymphoma of the optic chiasm. Systemic tre

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8

Acuña, María del Valle, Mariela Ogusuku, and Walter Briggiler. "Síndrome de Gorlin y afectación ocular." Oftalmología Clínica y Experimental 18, no. 2 (2025): e236-e242. https://doi.org/10.70313/2718.7446.v18.n2.424.

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Objectives: To describe the clinical and ophthalmologic features of Gorlin's syndrome, based on a case report. Case report: A 58-year-old male patient with a history of facial melanoma, who had left frontotemporal myiasis on hyperpigmented lesion and palpebral involvement, in addition to malformation of teeth and multiple facial nodular hyperpigmented lesions was consulted. Vision was severely compromised. After consultation with the head and neck surgery, oncology and dentistry services, a presumptive diagnosis of Gorlin's syndrome was made, based on the multisystemic signs observed. The pati

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9

Davila, Jose R., and Prithvi Mruthyunjaya. "Updates in imaging in ocular oncology." F1000Research 8 (October 1, 2019): 1706. http://dx.doi.org/10.12688/f1000research.19979.1.

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Innovations in ophthalmic imaging have made a profound impact on the diagnosis and treatment of ophthalmic disease. In ocular oncology, the development of optical coherence tomography with enhanced depth imaging and swept source technologies has made it possible to visualize the anatomical characteristics of retinoblastoma and uveal melanoma with a level of detail previously unobtainable on clinical exam alone. As a result, our understanding of the pathophysiology of vision loss in choroidal melanoma in particular has improved. These modalities have also helped identify fundoscopically “invisi

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10

Batis, Vasilios, James Shuttleworth, Garry Shuttleworth, and Gwyn Samuel Williams. "Diagnostic dilemma of ocular lymphoma." BMJ Case Reports 12, no. 6 (2019): e229513. http://dx.doi.org/10.1136/bcr-2019-229513.

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We report a very unusual presentation of primary intraocular lymphoma masquerading as anterior uveitis with atypical symptoms. A 68-year-old man, initially presented with a 4-day history of painless, left blurred vision. Examination revealed 2 or more anterior chamber cells, mutton-fat keratic precipitates and posterior synechiae. Treatment was initiated, the eye settled, and the patient was discharged. He re-presented 7 months later with hypopyon, a hazy cornea, fibrin deposits and a narrowed anterior chamber angle. Over the coming weeks, it became apparent that the temporal iris was thickene

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11

Elsheikh, Aliaa, Ahmed Selim, and Yasmine Shaaban. "AML-031 Acute Myeloid Leukemia With Unusual Ocular Presentation: A Case Report." Clinical Lymphoma Myeloma and Leukemia 23 (September 2023): S261. http://dx.doi.org/10.1016/s2152-2650(23)00980-1.

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12

Meller, Leo, Vasan Jagadeesh, Michael Oca, et al. "Cytomegalovirus Retinitis in an Eye with Unilateral Retinoblastoma: A Case Report." Case Reports in Ophthalmology 15, no. 1 (2024): 483–89. http://dx.doi.org/10.1159/000538738.

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Introduction: Cytomegalovirus (CMV) retinitis in the setting of pediatric retinoblastoma is exceedingly unusual. Here, we present the first reported case of CMV retinitis in an enucleated eye with retinoblastoma after chemotherapy in the western hemisphere. Case Presentation: A 2-year-old Hispanic male without a family history of retinoblastoma presented with a 3-month history of right eye exotropia and squinting. Clinical examination revealed dense white vitreous opacities in the right eye. Ocular oncology evaluation unveiled an exudative retinal detachment with vitreous seeds, subretinal see

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13

Hua, Rui, Wenya Li, Weiwei Wu, Jun Tao, and Qing Peng. "Failure of ocular photodynamic therapy for secondary choroidal metastasis: a case report and literature review." Oncotarget 8, no. 55 (2017): 95030–35. http://dx.doi.org/10.18632/oncotarget.21847.

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Elsheikh, Aliaa, Ahmed Selim, and Yasmine Shaaban. "POSTER: AML-031 Acute Myeloid Leukemia With Unusual Ocular Presentation: A Case Report." Clinical Lymphoma Myeloma and Leukemia 23 (September 2023): S168. http://dx.doi.org/10.1016/s2152-2650(23)00492-5.

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15

Idris, Ahmad Fitri, Michael John Martin, Ian R. Davidson, Gerard J. O'Sullivan, Ahmad A. Jamaludin, and Paul P. Donnellan. "Ocular melanoma liver metastases treated by percutaneous hepatic perfusion with melphalan followed by ipilimumab: A case report." Journal of Clinical Oncology 31, no. 15_suppl (2013): e20008-e20008. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e20008.

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e20008 Background: Patients with unresectable liver metastases from ocular melanoma have a poor prognosis with just 10% surviving 1 year with standard treatments. High-dose melphalan via percutaneous hepatic perfusion (PHP) and filtration system (ChemoSat, Delcath Inc.) is licensed in Europe for treatment of liver-only metastases from ocular melanoma and neuroendocrine tumours. Ipilimumab (Ipi), anti-CTLA4 immunotherapy is licensed in US and Europe for treatment of metastatic malignant melanoma. A 32-year-old man was referred to our unit with unresectable liver metastases from primary ocular m

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16

Shahzad, Orthi, Nicola Thompson, Gerry Clare, Sarah Welsh, Erika Damato, and Philippa Corrie. "Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm." Therapeutic Advances in Medical Oncology 13 (January 2021): 175883592199298. http://dx.doi.org/10.1177/1758835921992989.

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Ocular immune-related adverse events (IrAEs) associated with use of checkpoint inhibitors (CPIs) in cancer therapeutics are relatively rare, occurring in approximately 1% of treated patients. Recognition and early intervention are essential because the degree of tissue damage may be disproportionate to the symptoms, and lack of appropriate treatment risks permanent loss of vision. International guidelines on managing ocular IrAEs provide limited advice only. Importantly, local interventions can be effective and may avoid the need for systemic corticosteroids, thereby permitting the continuatio

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17

Kadir, Syeed Mehbub Ul, Tanjilla Hossain, and Md Golam Haider. "Hodgkin’s Lymphoma: A Rare Ophthalmic Case Report." Community Based Medical Journal 11, no. 2 (2022): 158–61. http://dx.doi.org/10.3329/cbmj.v11i2.61287.

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Hodgkin’s lymphoma (HL) is a disease originating from lymphoid tissues; however, it may pose a diagnostic challenge. Ocular involvement is more prevalent in non-HL compared to HL. We have reported a rare case of Hodgkin’s lymphoma presented with forwarding bulging of left eye with pain, redness, and watering. The patient also complained of painless swelling of the submandibular lymph node when admitted into the National Institute of Ophthalmology and Hospital (NIOH), Dhaka, Bangladesh; later, incision and biopsy was done at ENT & Head-Neck Cancer Hospital, Dhaka, Bangladesh. Histopathology

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18

Awadh, Hesham, Haresh Visweshwar, Jacob Kilgore, and Kara Willenburg. "Watch Out! Syphilis Is Back – Case Series of Four Cases of Ocular syphilis." Open Forum Infectious Diseases 4, suppl_1 (2017): S106. http://dx.doi.org/10.1093/ofid/ofx163.101.

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Abstract Background Syphilis is an ulcerative sexually transmitted genital infection caused by Treponema pallidum, which is a member of the order Spirochaetales, family Spirochaetaceae, and genus Treponema. The incidence rate of Syphilis has been steadily rising since 2000; from 2.1 cases per 100,000 population to up to 7.5 cases per 100,000 population in 2014–2015 (the highest rate since 1994). In the state of West Virginia, we have witnessed an increase in the number of cases from 0.5 cases per 100,000 population in 2011, to 5.9 cases per 100,000 population in 2015. Systemic symptoms can inc

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19

Chauhan, Ayushi F., Narine Viruni, T. Y. Alvin Liu, J. Fernando Arevalo, and Bruce D. Cheson. "Successful Treatment of Ocular Chronic Lymphocytic Leukemia with Ibrutinib: Case Report and Review of the Literature." Leukemia Research Reports 14 (2020): 100200. http://dx.doi.org/10.1016/j.lrr.2020.100200.

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20

Gherardi, Giovanni, Pier Luigi Surico, Marco Coassin, et al. "Meningococcal Conjunctivitis in a 54-Year-Old Man: Case Report and Review of the Literature." Chemotherapy 68, no. 4 (2023): 228–32. http://dx.doi.org/10.1159/000530894.

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Neisseria meningitidis represents an uncommon pathogen of acute bacterial conjunctivitis. In this brief report, we describe a case of meningococcal conjunctivitis in an immunocompetent adult male, with a review of the literature. The patient went to the outpatient ophthalmology clinic complaining of severe ocular discomfort, burning, and redness for more than 2 weeks and, at slit lamp examination, he was diagnosed with a mild conjunctivitis. Microbiology cultures of ocular swabs revealed the growth of colonies, as pure culture, identified as N. meningitidis of serogroup B. A diagnosis of prima

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21

Kaur, Jeeventh, Marko Popovic, Hatem Krema, and Keyvan Koushan. "Suprachoroidal and vitreous haemorrhage as a presenting feature of metastatic melanoma." BMJ Case Reports 16, no. 6 (2023): e249738. http://dx.doi.org/10.1136/bcr-2022-249738.

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A man in his 70s presented with right ocular pain, vision loss and temporal headache 4 days after undergoing laser peripheral iridotomy. The patient had lost 10 lbs over the preceding 6 weeks and had a medical history significant for a previously excised melanoma of the left arm. During the course of investigations, the patient was referred to oncology for workup, ultimately leading to a diagnosis of metastatic melanoma. Visceral metastases were identified in the lungs, right anterior fourth rib, left femoral distal diaphysis and medial side of the right globe. The patient decompensated and di

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Kumar, Sonali Vinay, Ashok Kumar, Manoj K. Semwal, and Sanjay Kumar Mishra. "Safety and efficacy of indigenously developed Ruthenium-106 eye plaque for brachytherapy of a spectrum of ocular tumors: A case series." Journal of Cancer Research and Therapeutics 19, Suppl 2 (2022): S912—S916. http://dx.doi.org/10.4103/jcrt.jcrt_1004_22.

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ABSTRACT Various treatment modalities are available for treatment of ocular tumors, which include chemotherapy, laser, and radiotherapy (external beam radiation therapy or brachytherapy). Brachytherapy using plaque applicator is preferred over external beam radiation therapy when the tumor is well localized, as this therapy delivers radiation dose to the tumor with lower doses to normal tissues in the vicinity. However, plaque therapy is expensive and beyond the reach of many poor patients in India. The Bhabha Atomic Research Center (BARC) recently introduced an indigenous Ruthenium-106 plaque

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Kelkar, Neil, and Jue Wang. "A comparative analysis of patients presenting with optic canal metastasis of prostate cancer." Journal of Clinical Oncology 41, no. 6_suppl (2023): 23. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.23.

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23 Background: Prostate cancer (PCa) is the second-most diagnosed cancer and the second leading cause of cancer deaths in United States Males. Due to an emphasis on early detection of PCa, only a small percentage present with distant disease. We report cases of ocular metastasis of PCa, a late finding of PCa. Methods: Systematic review of the literature and pooled analysis of published cases of PCa with optic canal or orbital metastasis, including one from our institution. A subgroup analysis compared those who presented with optic metastases as their initial presentation (IP) versus those who

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García Onrubia, Luis, Gabriela Estefanía Pacheco-Callirgos, Alejandro Portero-Benito, et al. "Spectrum of conjunctival tumours in a Spanish series: A review of 462 cases." European Journal of Ophthalmology 30, no. 6 (2019): 1403–9. http://dx.doi.org/10.1177/1120672119870736.

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Introduction: To report the spectrum and frequency of conjunctiva tumours in an ocular oncology unit analysing the clinical profile of benign, precancerous and malignant conjunctival lesions. Methods: A retrospective case series of 462 consecutive patients diagnosed at the Ocular Oncology Unit of the University Hospital of Valladolid from 1992 to 2017. Results: Among 462 consecutive patients, the tumour was classified as melanocytic in 252 (54.5%) and non-melanocytic in 210 (45.5). Two hundred forty-eight males (mean age 51.63 (SD = 23.20)) and 214 females (mean age 48.27 (SD = 21.77)) were in

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Jain, Rohit K., Rutika Mehta, and Sunil Badve. "Conjunctival Squamous Cell Carcinoma Due to Ocular Prostheses: A Case Report and Review of Literature." Pathology & Oncology Research 16, no. 4 (2010): 609–12. http://dx.doi.org/10.1007/s12253-010-9251-0.

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Onishi, Hideki, Mayumi Ishida, Iori Tanahashi, et al. "Wernicke encephalopathy without delirium in patients with cancer." Palliative and Supportive Care 16, no. 1 (2017): 118–21. http://dx.doi.org/10.1017/s1478951517000360.

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ABSTRACTObjective:Wernicke encephalopathy (WE) is a neuropsychiatric disorder caused by thiamine deficiency. Several reports of WE in cancer patients are known. WE is sometimes overlooked because most patients do not exhibit its typical symptoms (e.g., delirium, ataxia, ocular palsy). If delirium is not present, a diagnosis of WE is difficult because delirium is the hallmark symptom of WE.Method:Taken from a series on WE in cancer, we report two patients who developed WE without delirium during periodic psycho-oncology outpatient visits.Results:Case 1. A 61-year-old woman with non-Hodgkin lymp

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Ma, K., X. Wang, Y. Guo, and Y. Xu. "P3.08-15 Lung Squamous Cell Carcinoma with Solitary Ocular Metastasis，Successful Treatment: An Interesting and Rare Case Report." Journal of Thoracic Oncology 13, no. 10 (2018): S945. http://dx.doi.org/10.1016/j.jtho.2018.08.1766.

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KHALIFA, Y. EL, S. RACHDA, S. BELGHMAIDI, I. HAJJI, and A. MOUTAOUAKIL. "From Breast to Sclera: A Silent and Devastating Invasion." Ophthalmology Research: An International Journal 20, no. 2 (2025): 15–22. https://doi.org/10.9734/or/2025/v20i2453.

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Aim: This case report highlights about a silent and devastating invasion of Scleral metastases. Introduction: Ocular metastases remain a rare manifestation of systemic malignancies. Scleral involvement is an exceptionally uncommon presentation, often mimicking inflammatory conditions, which may delay diagnosis and management. Case Presentation: We present the case of a 48-year-old woman with a history of left breast invasive ductal carcinoma diagnosed three years earlier. She underwent conservative treatment, lymph node dissection, chemotherapy, radiotherapy, and was maintained on Tamoxifen. S

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Onishi, Hideki, Mayumi Ishida, Iori Tanahashi, et al. "Early detection and successful treatment of Wernicke's encephalopathy in outpatients without the complete classic triad of symptoms who attended a psycho-oncology clinic." Palliative and Supportive Care 16, no. 5 (2018): 633–36. http://dx.doi.org/10.1017/s1478951518000032.

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AbstractObjectiveWernicke's encephalopathy (WE) is a neuropsychiatric disorder caused by a thiamine deficiency. Although WE has been recognized in cancer patients, it can be overlooked because many patients do not exhibit symptoms that are typical of WE, such as delirium, ataxia, or ocular palsy. Furthermore, outpatients with WE who intermittently present at psycho-oncology clinics have not been described as far as we can ascertain.MethodThis report describes two patients who did not exhibit the complete classic triad of symptoms among a series with cancer and WE, and who attended a psycho-onc

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Rahmartani, Ludi Dhyani. "LINC-36. TRILATERAL RETINOBLASTOMA: A REPORT OF FOUR CASES." Neuro-Oncology 22, Supplement_3 (2020): iii385. http://dx.doi.org/10.1093/neuonc/noaa222.470.

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Abstract Retinoblastoma is the most common primary malignant intraocular cancer that usually develops in early childhood. About 5% of those patients are at risk of developing trilateral retinoblastoma (TRB). In developing countries, most of them came in the late stage; therefore, ocular and patient survival rates are lower than in developed countries. From 2015–2019, we found four cases of trilateral retinoblastoma. Two of them had bilateral retinoblastoma, and two had unilateral retinoblastoma. They all presented with leukocoria and had no family history of retinoblastoma. The mean age was 13

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Fraimow, Henry S., Susan E. Beekmann, Philip M. Polgreen, and James Sunstrum. "1351. How Do Infectious Diseases Clinicians Manage Patients with Suspected Ocular Tuberculosis? Results of an Emerging Infections Network Survey." Open Forum Infectious Diseases 6, Supplement_2 (2019): S489. http://dx.doi.org/10.1093/ofid/ofz360.1215.

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Abstract Background Ocular tuberculosis (OTb) is uncommon and many ID physicians (IDPs) have limited experience with OT. Ophthalmologists now include IGRAs in evaluating idiopathic uveitis, and some IDPs report increased referrals for possible OTb. Our goal was to understand how IDPs approach diagnosis, treatment, and reporting of OTb. Methods The Emerging Infections Network surveyed members treating adult ID patients in 2019 about referrals for suspected OTb. The survey used hypothetical case scenarios to evaluate factors influencing the management of possible OTb, and queried involvement of

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Husain, A., D. Roberts, B. Pro, P. McLaughlin, and B. Esmaeli. "Meta-analyses of the association between Chlamydia psittaci and ocular adnexal lymphoma and the response of ocular adnexal lymphoma to antibiotics." Journal of Clinical Oncology 25, no. 18_suppl (2007): 8090. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8090.

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8090 Background: There are conflicting reports regarding the association between Chlamydia psittaci (Cps) and ocular adnexal lymphoma (OAL) and the efficacy of antibiotics for OAL. We sought to clarify the association between Cps and OAL and the efficacy of antibiotics for OAL. Methods: We conducted 2 meta-analyses. One focused on Cps association with OAL across geographic regions and among different studies. The other was a meta-analysis of responses to antibiotic treatment. Results: We identified 10 studies of Cps prevalence which included 430 cases of OAL from 10 different countries. We fou

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Burtness, Barbara, Milan Anadkat, Surendra Basti, et al. "NCCN Task Force Report: Management of Dermatologic and Other Toxicities Associated With EGFR Inhibition in Patients With Cancer." Journal of the National Comprehensive Cancer Network 7, Suppl_1 (2009): S—5—S—21. http://dx.doi.org/10.6004/jnccn.2009.0074.

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This NCCN Task Force Report describes the management of dermatologic and ocular toxicities that occur in patients treated with epidermal growth factor receptor (EGFR) inhibitors. Task force members are from NCCN member institutions and include oncologists, dermatologists, an ophthalmologist, and a mid-level oncology provider. This report describes commonly used therapies that the task force agreed are appropriate standards of care for dermatologic and ophthalmologic toxicities associated with EGFR inhibitors, which generally are supported only by anecdotal evidence. Few recommendations are evi

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Lerner, M. Yu, and O. N. Steshenko. "Malignant eyelid tumors: epidemiology and clinical observation of patients in Moscow." Russian Ophthalmological Journal 15, no. 4 (2022): 38–44. http://dx.doi.org/10.21516/2072-0076-2022-15-4-38-44.

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Purpose: to assess the prevalence of primary malignant eyelid tumors and their prognostic features based on the materials of the ocular oncology department, Moscow Ophthalmological Center. Materials and methods. We performed a retrospective analysis of 10-year array (2010–2019) of documents of the Moscow Cancer Register, reports of the ocular oncology department of the Moscow ophthalmological center, S.P. Botkin State Clinical Hospital, and case histories of outpatients with malignant eyelid tumors, residing in Moscow. Results. Malignant ocular tumors were diagnosed in 3650 people. Of these, 7

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Willier, Semjon, Johannes Raedler, Franziska Blaeschke, et al. "Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e001052. http://dx.doi.org/10.1136/jitc-2020-001052.

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BackgroundRelapsed/refractory B-precursor acute lymphoblastic leukemia (BCP-ALL) remains a major therapeutic challenge in pediatric hematology. Chimeric antigen receptor (CAR) T cells targeting CD19 have shown remarkable initial response rates in BCP-ALL patients, while long-term leukemia control rate is only about 50%. So far, main mechanisms of BCP-ALL relapse after CD19-CAR T-cell therapy have been either insufficient CAR T-cell persistence in vivo or loss of surface CD19.Case ReportHere, we report an exceptional presentation of BCP-ALL relapse in the eye during the systemic control through

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Zugbi, Santiago, Daiana Ganiewich, Arpita Bhattacharyya, et al. "Clinical, Genomic, and Pharmacological Study of MYCN-Amplified RB1 Wild-Type Metastatic Retinoblastoma." Cancers 12, no. 9 (2020): 2714. http://dx.doi.org/10.3390/cancers12092714.

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An uncommon subgroup of unilateral retinoblastomas with highly aggressive histological features, lacking aberrations in RB1 gene with high-level amplification of MYCN (MCYNamplRB1+/+) has only been described as intra-ocular cases treated with initial enucleation. Here, we present a comprehensive clinical, genomic, and pharmacological analysis of two cases of MCYNamplRB1+/+ with orbital and cervical lymph node involvement, but no central nervous system spread, rapidly progressing to fatal disease due to chemoresistance. Both patients showed in common MYCN high amplification and chromosome 16q a

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Vazquez-Medina, Johan V., Gilberto Cisneros-Rodríguez, Elda V. Landeros-Rosales, and Itzel G. García-Félix. "Orbital Alveolar Rhabdomyosarcoma in A 26-Year-Old Woman At 23 Weeks Gestation: Case Report." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 742–48. https://doi.org/10.5281/zenodo.15447933.

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Alveolar orbital rhabdomyosarcoma is a rare malignant neoplasm in adults and even more uncommon during pregnancy, characterized by aggressive behavior and poor prognosis. We present the case of a 26-year-old woman at 23 weeks of gestation with progressive proptosis, diplopia, and decreased visual acuity. Magnetic resonance imaging revealed an expansive orbital lesion, histologically confirmed as alveolar rhabdomyosarcoma. Management required a multidisciplinary approach, prioritizing maternal-fetal stability while establishing an appropriate oncologic therapeutic strategy. This case discusses

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Thomas, Steffi, Chay Bae, Tabanor Joy-Ann, and William Traverse. "Behcet’s-like syndrome following pembrolizumab: An immune-related adverse event associated with programmed death receptor-1 inhibitor therapy." Journal of Oncology Pharmacy Practice 26, no. 4 (2019): 995–99. http://dx.doi.org/10.1177/1078155219877219.

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Introduction The landscape for the treatment of metastatic melanoma has been revolutionized with the introduction immune checkpoint inhibitors. Immune checkpoint inhibitors have now become the standard of care for the treatment of cancers. These immune agents including programmed death receptor-1 inhibitors, programmed death-ligand 1 inhibitors and cytotoxic T-lymphocyte antigen-4 inhibitors have shown promising results but have been associated with numerous immune-related complications. Pembrolizumab, a programmed death receptor-1 inhibitor, has been associated with a number of immune-related

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Telfah, Mohammad, Thomas J. Whittaker, and Gary C. Doolittle. "Vision loss with pembrolizumab treatment: A report of two cases." Journal of Oncology Pharmacy Practice 25, no. 6 (2019): 1540–46. http://dx.doi.org/10.1177/1078155219841683.

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BackgroundVision loss and other ocular toxicities are rare, but detrimental, side effects of immune checkpoint inhibitors. Herein, we report two patients who developed vision loss while on pembrolizumab treatment.Cases presentationCase 1 – A 58-year-old man was started on pembrolizumab for advanced melanoma. He was tolerating the treatment well. After receiving 14 cycles of pembrolizumab, he developed acute bilateral vision loss and occipital headaches. An emergent ophthalmologic evaluation revealed bilateral shallow choroidal effusion with bilateral focal exudative retinal detachment. After e

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Jamison, Aaron, Julie Connolly, Paul Cauchi, Chee Thum, and Vikas Chadha. "Multifocal Intraretinal Tumour Deposits following Treatment of an Ipsilateral Choroidal Melanoma." Ocular Oncology and Pathology 6, no. 6 (2020): 410–15. http://dx.doi.org/10.1159/000510575.

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<b><i>Background/Aims:</i></b> The aim of this study was to report a patient who, following plaque brachytherapy for a choroidal melanoma, developed two separate retinal foci of malignant melanoma in the same eye, and suggest possible mechanisms that might explain such an occurrence. <b><i>Methods:</i></b> We conducted a retrospective case report. <b><i>Results:</i></b> A 79-year-old Caucasian male developed a left inferotemporal choroidal melanoma in 2016 and subsequently underwent ruthenium-106 plaque brachytherapy under

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Maya Naranjo, Maria Isabel, Sebastián Vallejo López, Sara Mesa Mesa, et al. "Intravitreal methotrexate in type B lymphoblastic leukemia—Case Report." Frontiers in Oncology 13 (August 28, 2023). http://dx.doi.org/10.3389/fonc.2023.1237204.

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Leukemia is a common neoplasia that, in its progress, can have ocular involvement due to direct infiltration or secondary to hematological alterations typical of the disease. These findings are consistent with an involvement of the central nervous system and are thus related to the prognosis. Despite the existing systemic therapies, there needs to be more literature that shows the treatment in the ocular involvement of this disease. A case report of a child with ocular involvement due to treatment-refractory acute lymphoblastic leukemia, successfully managed with intravitreal methotrexate, is

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Ng, Jia, Muhayman Sadiq, and Qasim Mansoor. "Ocular toxicity following carboplatin chemotherapy for neuroendocrine tumour of the bladder." Journal of Oncology Pharmacy Practice, August 24, 2022, 107815522211220. http://dx.doi.org/10.1177/10781552221122005.

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Introduction Carboplatin is a commonly used platinum analogue chemotherapeutic agent that is similar to cisplatin but is known to be better tolerated. This case report outlines a case of ocular toxicity following carboplatin chemotherapy used for the management of a neuroendocrine tumour of the bladder. Case report A 70-year-old man with a history of neuroendocrine bladder cancer underwent chemotherapy with carboplatin and etoposide. He presented 4 weeks following his fourth chemotherapy cycle with a 1-week history of right eye blurriness. The patient had suffered a similar episode 2 weeks fol

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Kobayashi, Takaaki, Bradley Ford, Nobuhiro Fujita, and A. Ben Appenheimer. "Ocular Actinomycosis Mimicking Meningioma." Open Forum Infectious Diseases 7, no. 6 (2020). http://dx.doi.org/10.1093/ofid/ofaa170.

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Abstract Orbital actinomycosis is an unusual clinical manifestation of orbital infection caused by Actinomyces species. Herein we report a case of orbital actinomycosis in a 67-year-old woman with recurrent swelling and erythema around her left eye with an orbital mass initially thought to be a meningioma.

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Amir, Amaar, Baraa Amir, and Salwa Sheikh. "A case of primary conjunctival follicular lymphoma presenting as nasolacrimal obstruction." Journal of Surgical Case Reports 2023, no. 11 (2023). http://dx.doi.org/10.1093/jscr/rjad616.

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Abstract We herein report a 76-year-old male who presented to the ophthalmology clinic after complaining from excessive lacrimation for ~6 months prior to presentation. He reports previously undergoing a nasolacrimal recanalization procedure in attempts to resolve his symptoms, but reported no improvement. On examination, a mass on the nasal conjunctiva around the medial canthus of the right eye was noted and subsequently excised. The findings support the diagnosis of low-grade follicular lymphoma. The patient was referred to radiation oncology for radiation therapy and received a total dose o

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Tan, Nicholas, Rahul Sampath, Omar M. Abu Saleh, et al. "Disseminated Mycobacterium chimaera Infection After Cardiothoracic Surgery." Open Forum Infectious Diseases 3, no. 3 (2016). http://dx.doi.org/10.1093/ofid/ofw131.

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Abstract Ten case reports of disseminated Mycobacterium chimaera infections associated with cardiovascular surgery were published from Europe. We report 3 cases of disseminated M chimaera infections with histories of aortic graft and/or valvular surgery within the United States. Two of 3 patients demonstrated ocular involvement, a potentially important clinical finding.

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Lam, Sophia S., Dilru C. Amarasekera, and Reza Razeghinejad. "Chronic angle closure glaucoma with an atypical iris-pupillary membrane." European Journal of Ophthalmology, June 30, 2022, 112067212211117. http://dx.doi.org/10.1177/11206721221111700.

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Purpose To report the presentation and management of a 65-year-old female who presented with chronic angle closure glaucoma and an atypical iris membrane. Case Report A 65-year-old healthy female with no significant past medical history presented to the emergency room with a 2-day history of headache, blurry vision, and right ocular pain. She denied any such prior episodes, any prior ocular history including ocular trauma, or a family history of glaucoma. She was diagnosed with bilateral, severe chronic angle closure glaucoma with an atypical, pigmented iris-pupillary membrane in the right eye

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Nguyen, Charles B., Christopher T. Su, Meredith Morgan, and Ajjai S. Alva. "Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma." Frontiers in Oncology 12 (October 6, 2022). http://dx.doi.org/10.3389/fonc.2022.1000023.

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Ocular immune-related adverse events are a relatively rare complication of immune checkpoint inhibitors. Common ocular toxicities range from dry eyes to inflammatory uveitis and ocular myasthenia gravis. Here, we present the case of a 55-year-old woman with recurrent urothelial carcinoma of the ureter after initially being managed with neoadjuvant cisplatin-based chemotherapy and surgical resection. She was treated with pembrolizumab which was complicated by immune-mediated pneumonitis after the eighth cycle, which was managed with a prolonged steroid course. The patient also developed red eye

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Thomas, Miles, John Benfield, and Joshua Morales. "Case Report of Seronegative Cancer-Associated Retinopathy in a Patient with Small Cell Lung Carcinoma." Case Reports in Oncology, September 4, 2023, 791–96. http://dx.doi.org/10.1159/000531624.

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Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome characterized by autoimmune destruction of photoreceptor cells. It is associated with several tumor types, including small cell lung carcinoma (SCLC). Corticosteroids have been the mainstay treatment for CAR, although no therapeutic standard has truly been established. A 66-year-old female with significant smoking history and age-related macular degeneration (ARMD) presented with rapidly declining bilateral visual acuity. Ophthalmologic examination findings appeared consistent with the known diagnosis of ARMD but did not oth

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Patel, Monica A., Rachel L. McDevitt, Will Sassack, and Mark M. Zalupski. "Motor “freezing” with oxaliplatin." Journal of Oncology Pharmacy Practice, March 26, 2021, 107815522110049. http://dx.doi.org/10.1177/10781552211004985.

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Introduction We report the case of a patient who experienced severe neurological symptoms collectively characterized as being “frozen” following a second oxaliplatin infusion. Case report A 52-year-old woman with metastatic colon cancer developed severe motor slowing, delayed and incomplete grip and dorsiflexion, speech difficulty, visual impairment, leg cramping and tingling after her second infusion of oxaliplatin. She was transferred from the infusion center to the emergency room and admitted to the hospital for further evaluation. Motor, verbal, and ocular symptoms gradually resolved withi

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Elhaitmy, Youssef, Soukaina El Anssari, Pierre Fournel, Nawfel Mellas, Wafa Bouleftour, and Michele Lamuraglia. "Case report: Immunotherapy inducing unexpected overall survival in choroidal melanoma: about a case." Frontiers in Oncology 14 (April 19, 2024). http://dx.doi.org/10.3389/fonc.2024.1319792.

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Choroidal melanoma (CM) is the most common malignant ocular tumor in adults. The current treatment of metastatic CM is limited by the intrinsic resistance of CM to conventional systemic therapies. Immunotherapy alone or in association with cytotoxic treatment became a realist option treatment. Advancements in molecular biology have resulted in the identification of a number of promising prognostic and therapeutic targets. Herein, we report a rare case of 36-year-old patient with metastatic CM who presented a good long response to treatment with double immunotherapy reaching 3 years of overall

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