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Rozprawy doktorskie na temat „Opioid dependence”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Nosyk, Bohdan. "Empirical studies in opioid dependence." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23718.

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Background: Opioid dependence is a chronic disease characterized by periods of relapse and remission. Methadone maintenance treatment (MMT) can be effective, though not all patients can be successfully maintained in treatment. Further, treatment entrants often use multiple illicit drugs, a fact whose motive and effect are under-studied. Rigorous evaluation at the aggregate- and patient-level is required to maximize the public health benefits of substance abuse treatment. Objectives: (1) identify the determinants of the time to discontinuation of MMT across multiple treatment episodes; (2

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Edmund, Christine Hilary. "Correctional Nurses: Adult Opioid Dependence Referral Process." NSUWorks, 2017. https://nsuworks.nova.edu/hpd_con_stuetd/26.

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Background: Correctional nurses make up a large part of the corrections workforce and have increasing responsibility for making decisions about patient care in the opioid dependent incarcerated patients. The National Commission on Correctional Health Care (NCCHC) has intoxication and withdrawal standards that advocate individuals entering a correctional facility under the influence or undergoing withdrawal from opioids have their therapy continued, or a plan for appropriate referral for treatment. The NCCHC standard that incarcerated opioid dependent inmates have their therapy continued or a p

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Bilsky, Edward James 1967. "Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282311.

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The central hypothesis of this dissertation is that agonists and antagonists acting at the delta opioid receptor will have therapeutic applications in treating acute and chronic pain states and in the treatment of drug addiction. It is further hypothesized that delta compounds will have better therapeutic profiles than currently available opioids that act predominantly at the mu receptor. In advancing the central hypothesis, selective nonpeptidic delta compounds, that readily cross the blood brain barrier after systemic administration, were tested. BW373U86, a nonpeptidic ligand with moderate

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Weich, Lize, Charles Perkel, Zyl Nicolette Van, S. T. Rataemane, and Lochan Naidoo. "Medical management of opioid dependence in South Africa." Health and Medical Publishing Group (HMPG), 2008. http://hdl.handle.net/10019.1/7055.

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The original publication is available at http://www.samj.org.za<br>Medical practitioners in South Africa are increasingly confronted with requests to treat patients with opioid use disorders. Many do not possess the required knowledge and skills to deal with these patients effectively. This overview of the medical treatment of opioid dependence was compiled by an elected working group of doctors working in the field of substance dependence. Recommendations are based on current best practice derived from scientific evidence and consensus of the working group, but should never replace individual

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Fundytus, Marian Elaine. "Contribution of metabotropic glutamate receptors to opioid dependence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ29938.pdf.

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Johansson, Anna. "Dependence-induced changes in opioid-receptor gene expression." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034.

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Using drugs such as alcohol and morphine among others can be addictive in some individuals, and progress into a substance abuse disorder. The mesolimbic dopaminergic system (MD-system) is involved in the reward process during the development of drug addiction. The MD-system is critical for survival and affects different behaviors in both man and animal. Neurochemical pathways drive for instance physical activity, food intake, love and reproduction and are part of the natural reward process involved partly in the release of dopamine (DA) into frontal lobes. Within the MD-system opioid receptors

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Fundytus, Marian Elaine. "Contribution of metabotropic glutamate receptors to opioid dependence." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42034.

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We investigated the role of metabotropic glutamate receptors (mGluRs), and related intracellular second messengers, in the development of morphine tolerance and dependence. The mGluRs are divided into three groups: group I mGluRs are positively coupled to phosphatidylinositol (PI) hydrolysis, while group II and III mGluRs are negatively coupled to cyclic adensoine-3$ sp prime$,5$ sp prime$-monophosphate (cAMP) production. Opioid receptors are also coupled to these same systems, and have been shown to elicit changes in these messenger systems during chronic treatment.<br>We showed that chronic

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Grivas, Konstantinos. "Analogues of buprenorphine as treatment for opioid dependence." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294430.

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Higgins, Cassandra. "Comorbid opioid dependence and chronic pain : clinical implications." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/bbc038cc-562c-4e01-a617-147de73b1312.

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Context Chronic pain and opioid dependence confer substantial individual and societal burdens and are notoriously difficult to treat effectively. Their comorbid presentation further complicates effective treatment through complex physiological and environmental interactions. Objectives (1) What are the clinical characteristics and treatment outcomes associated with comorbid chronic pain in ORT patients? (2) Does the patient-attributed direction of the causal relationship in the development of opioid dependence and chronic pain identify two clinically-distinct treatment populations? (3) What is

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Cradick, Mary, Shannon DeGrote, Spencer Marsall, and Terri Warholak. "Suboxone for Medically Assisted Treatment for Opioid Dependence." The University of Arizona, 2014. http://hdl.handle.net/10150/614151.

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Class of 2014 Abstract<br>Specific Aims: To show that Suboxone is more effective than no MAT (Medically Assisted Treatment) in opioid dependence. Additionally, that Suboxone is as effective as methadone in MAT. Methods: This study was a retrospective chart review of probationer’s case files at The Pima County Adult Probation Office. Treatment groups included: Suboxone (n=16), methadone (n=15), and no MAT control group (n=15). The total sample size was 46 probationers. The primary dependent variables were the number of negative events and tim

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Maloney, Elizabeth Ann National Drug &amp Alcohol Research Centre Faculty of Medicine UNSW. "Opioid dependence: associations with suicidal behaviour and other psychiatric comorbidity." Publisher:University of New South Wales. National Drug & Alcohol Research Centre, 2008. http://handle.unsw.edu.au/1959.4/41455.

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Suicide attempts and opioid dependence are important clinical issues, as both are associated with a high degree of psychiatric morbidity and elevated risk of mortality. Research has identified a number of risk factors for suicide attempts among the general population, and to a lesser extent, among heroin users. Due to a lack of case-control studies, however, it is still not known to what extent opioid dependence per se is a risk factor for suicide attempts. This thesis comprised the first study to directly examine whether opioid dependence is a unique risk factor of suicide attempts. This thes

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Lee, Franklin. "The Effects of Rhes on Opioid Analgesia." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1254.

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Rhes (Ras homolog enriched in striatum) has been identified as a novel monomeric G-protein involved in dopaminergic and other signaling in the striatum. Given the many effects of opioids that involve striatal circuitry, genetically engineered mice that are incapable of making Rhes (rhes-/-) and their control littermates (rhes+/+) were subjected to behavioral tests to determine if any differences existed in opioid analgesia, tolerance, withdrawal, reward, and locomotion. Rhes-/- mice showed an increased opioid mediated analgesia, along with an absence of tolerance and decrease in withdrawal whe

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Bennett, Ryan. "Association Tests of the Opioid Receptor System and Alcohol-Related Traits." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1993.

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The opioid receptors and their endogenous ligands have long been implicated in a variety of traits including addiction, impulsive behaviors and substance dependence. Using phenotypic measurements collected from the IASPSAD, data from a latent class analysis and data from a SNP array and additional genotyping assays, association and regression tests were performed to determine the effects of common SNPs encoded in the genes of the opioid receptors and ligands on various traits relating to alcohol dependence. Although only one SNP can be reported as significant for substance dependence within

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Culp, Jenna L. "Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12336.

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Thesis (M.A.)--Boston University<br>Cocaine use among opioid dependent persons is common, with an estimated 40 to 70% of those seeking treatment for opioid dependence, also using cocaine (Sullivan et al., 2011 ). The effects of cocaine use on treatment outcomes for those seeking medication assisted treatment (MAT) for opioid dependence are not well understood. Buprenorphine, prescribed under the brand name Suboxone, has recently emerged as a convenient, effective method of MAT. The Facilitated Access to Substance Abuse Treatment with Prevention And Treatment of HIV (FAST PATH) program at Bost

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Nelson, Renee. "Neurocognitive Examination of Attentional Bias and Inhibitory Control Alterations in Prescription Opioid Dependence." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37478.

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Prescription opioid (PO) abuse is a growing public health concern worldwide as evidenced by an increasing number of opioid-related hospital admissions with a striking lack of research examining the neural basis underlying cognitive symptomatology. Drugs of abuse, through their impact on the dopaminergic system, are thought to disrupt the cognitive network regulating impulse control and incentive salience through inhibition of goal-oriented behaviour and drug-induced attentional biases. The objective of the present study is to examine neurocognitive processes in PO abusers (vs. healthy controls

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Zarnegar, Parisa. "In vitro and postmortem studies of the brain opioid system: association to opiate dependence /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-904-1/.

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Watson, Benjamin James. "Neurobiological mechanisms underlying the motivational process in chronic opioid and alcohol dependence." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633450.

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Chronic opioid and alcohol dependence are widespread problems with enormous associated individual and societal costs. The disruption of normal motivational processes is characteristic in addiction and studying the neurobiological mechanisms involved is key to helping develop treatments. This thesis has studied specific mechanisms in two different ways, firstly using neuroimaging and secondly by applying existing understanding to trial a novel treatment approach. The central role played by the mesolimbic dopaminergic system in the motivational system is well established, however compared to oth

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Bazov, Igor. "Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-270321.

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Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. This thesis focuses on regulation of transcription of the opioid/nociceptin genes, the largest neuropeptide family, and on identification of adaptive changes in these mechanisms associated with alcoholism as model human pathology. Two epigenetic mech

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Altarifi, Ahmad. "EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/518.

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Pain is a significant health problem. Mu opioid receptor agonists are used clinically as analgesics, but their use is constrained by high abuse liability. Intracranial self-stimulation (ICSS) is a preclinical behavioral procedure that has been used to assess abuse potential of opioids, and drug-induced facilitation of ICSS is interpreted as an abuse-related effect. ICSS can also be used as a behavioral baseline to detect affective dimensions of pain. Specifically, pain-related depression of ICSS can model pain-related depression of behavior and mood, and drug-induced blockade of pain-related

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Corder, Gregory F. "INJURY ESTABLISHES CONSTITUTIVE µ-OPIOID RECEPTOR ACTIVITY LEADING TO LASTING ENDOGENOUS ANALGESIA AND DEPENDENCE." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/10.

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Injury causes increased pain sensation in humans and animals but the mechanisms underlying the emergence of persistent pathological pain states, which arise in the absence of on-going physical damage, are unclear. Therefore, elucidating the physiological regulation of such intractable pain is of exceptional biomedical importance. It is well known that endogenous activation of µ-opioid receptors (MORs) provides relief from acute pain but the consequences of prolonged endogenous opioidergic signaling have not been considered. Here we test the hypothesis that the intrinsic mechanisms of MOR signa

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Sribanditmongkol, Pongruk. "Inhibition of morphine tolerance and dependence by diazepam and its relation to opioid peptides /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487849696964501.

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Gibson, Amy Elizabeth National Drug &amp Alcohol Research Centre Faculty of Medicine UNSW. "Mortality among the recipients of methadone, buprenorphine and naltrexone maintenance for the treatment of opioid dependence: the levels, predictors and causes of mortality." Awarded By:University of New South Wales. National Drug & Alcohol Research Centre, 2009. http://handle.unsw.edu.au/1959.4/44508.

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Opioid dependence is a complex and persistent disorder with a high mortality rate and severe impact on health and social situation. It is associated with much harm, including the transmission of blood-borne bacterial and viral infections, self-harm, traumatic injury and drug overdose. All of these harms carry a risk of death, and accordingly, mortality rates in opioid-dependent people are many times higher than those in the general population of the same age and sex. One of the more commonly used strategies for reducing the risks of opioid dependence is the provision of maintenance treatment.

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Jali, Abdulmajeed. "DISCOVERY OF MOR SELECTIVE, REVERSIBLE OPIOID ANTAGONIST FOR POTENTIAL USE IN TREATMENT OF DRUG DEPENDENCE." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5020.

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Abstract DISCOVERY OF MOR SELECTIVE, REVERSIBLE OPIOID ANTAGONIST FOR POTENTIAL USE IN TREATMENT OF DRUG DEPENDENCE Abdulmajeed M. Jali, M.S. A thesis submitted in partial fulfillment of the requirements of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2017 Director: Dana E. Selley, Ph. D., Department of Pharmacology and Toxicology Opioid dependence/addiction is a major public health problem that is associated with multiple health and social costs. Pharmacotherapeutic treatment has been relatively effective, but the risk of relapse after treatment rem

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Loveday, William A. "Prescription opioid analgesic drug misuse: What can we learn from doctor-shopping behaviour." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/108061/1/William_Loveday_Thesis.pdf.

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This thesis examined the phenomenon of 'doctor shopping' for prescription opioid drugs in Queensland to identify whether aspects of this behaviour could be used better identify drug misuse and to assist doctors in better treatment of patients. Findings suggest that doctor shopping is a complex and uncommon behaviour in patients receiving prescription opioid drugs and not necessarily associated with aberrant drug use. It appears that long-term high dose use of prescription opioids is a greater indicator of concern and potential risk of harm. These outcomes have relevance to the implementation o

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Dipzinski, Aaron. "Comparison of Washington state 2010 Medicare prescription drug plan coverage of pharmacotherapies for opioid and alcohol dependence." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Thesis/Spring2010/A_Dipzinski_042310.pdf.

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Thesis (M.H.P.A.)--Washington State University, May 2010.<br>Title from PDF title page (viewed on July 22, 2010). "Department of Health Policy and Administration." Includes bibliographical references (p. 42-51).

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Nikic, Matthew James. "Factors affecting treatment outcome in opioid dependence substitution treatment : the influence of mood and withdrawal symptoms /." Title page, abstract and table of contents only, 2004. http://web4.library.adelaide.edu.au/theses/09HS/09hsn692.pdf.

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Ouzounian, Nicole Marie. "A Phenomenological Research Study on the Treatment Experience of Opioid Addicts: Exploring the Intrapersonal and Interpersonal Conflicts that Opioid Addicts Face During the Treatment Process." Diss., NSUWorks, 2018. https://nsuworks.nova.edu/shss_dcar_etd/118.

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Opioid addiction is a physical, mental, and social issue. The insidious habits and behaviors acquired while living an addictive lifestyle are more powerful than human comprehension, and the training required to release these strongholds are extreme to say the least. Capturing the lived experiences of this process is needed to increase understanding of the development that leads to transformation from active addict to addict in recovery. This phenomenological research study on the treatment experience of opioid addicts used a qualitative approach to gain understanding of this phenomenon. For th

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Hussain, Muhammad Zubair. "Molecular Adaptations in the Endogenous Opioid System in Human and Rodent Brain." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205133.

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The aims of the thesis were to examine i) whether the endogenous opioid system (EOS) is lateralized in human brain areas involved in processing of emotions and pain; ii) whether EOS responses to unilateral brain injury depend on side of lesion, and iii) whether in human alcoholics, this system is involved in molecular adaptations in brain areas relevant for cognitive control of addictive behavior and habit formation. The main findings were that (1) opioid peptides but not opioid receptors and classic neurotransmitters are markedly lateralized in the anterior cingulate cortex involved in proces

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Klintenberg, Rebecka. "Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3331.

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Elbegdorj, Orgil. "DESIGN, SYNTHESES, AND BIOLOGICAL EVALUATION OF 14-N-SUBSTITUTED NALTREXONE DERIVATIVES AS OPIOID RECEPTOR LIGANDS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/455.

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Opium, the dried resin obtained from the unripe seedpods of the poppy flower, has been used for medicinal and euphoric purposes since ancient times. Morphine, the main active ingredient of opium, and other clinically useful opioid analgesics all mediate their effects through activating the mu opioid receptor. Studies involving the mu opioid receptor knockout mice showed that the interaction with the mu opioid receptor is also responsible for many notorious side effects associated with these drugs including dependence and addiction. Therefore, selective antagonists for the mu opioid receptor

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Raehal, Kirsten Michele. "Opioid-Induced Side Effects in Beta-arrestin2 adn G Protein-Coupled Receptor Kinase Knockout Mice." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1236884585.

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Choski, Charvi, Kesheng Wang, Ying Liu, Olakunle Oni, Youssoufou Ouedraogo, and Shimin Zheng. "Effects of Buprenorphine and Methadone on Hypertension in Patients with Opioid Dependence: a Randomized Clinical Trial Study." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/326.

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Background: The misuse and addiction to opioids are one of the major health and social problem that is associated with an increase in morbidity and mortality. Both Buprenorphine (BUP) and Methadone (MET) are FDA-approved treatments for opioid dependence. This longitudinal study is to determine the effects of BUP and MET on hypertension in patients with opioid dependence using a Generalized Estimating Equation(GEE) Model. Methods: The data is from National Drug Abuse Treatment Clinical TrialsNetwork (CTN) protocol CTN-0027. This is a randomized study of 1,934 opioid dependence participants seek

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Soyka, Michael, Jens Strehle, Jürgen Rehm, Gerhard Bühringer, and Hans-Ulrich Wittchen. "Six-Year Outcome of Opioid Maintenance Treatment in Heroin-Dependent Patients: Results from a Naturalistic Study in a Nationally Representative Sample." Karger, 2017. https://tud.qucosa.de/id/qucosa%3A71616.

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Background: In many countries, the opioid agonists, buprenorphine and methadone, are licensed for maintenance treatment of opioid dependence. Many short-term studies have been performed, but little is known about long-term effects. Therefore, this study described over 6 years (1) mortality, retention and abstinence rates and (2) changes in concomitant drug use and somatic and mental health. Methods: A prevalence sample of n = 2,694 maintenance patients, recruited from a nationally representative sample of n = 223 substitution doctors, was evaluated in a 6-year prospectivelongitudinal naturalis

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Stevenson, Erin. "EXAMINING CHRONIC NON-CANCER PAIN AMONG A SAMPLE OF INDIVIDUALS IN OPIOID TREATMENT PROGRAMS." UKnowledge, 2012. http://uknowledge.uky.edu/csw_etds/2.

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National rates of chronic non-cancer pain (CNCP) are rising alongside increasing reports of prescription opioid abuse and mortality. Associations between the rise in CNCP and in opioid abuse seem logical, yet research on CNCP among individuals with opioid dependence is currently limited due to the complicated nature of comorbid conditions in research and treatment. This study aims to expand the CNCP knowledge base by responding to the question: Do individuals with CNCP participating in an opiate treatment program have better or worse treatment outcomes than individuals without CNCP? This study

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Olofsson, Anna. "Farmakologisk behandling vid opioidberoende : Finns det skillnader i effekt mellan buprenorfin- och metadonbehandling?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-75068.

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Bakgrund: Heroin är en opiat ursprungen från opiumvallmon och är starkt förknippad med beroende och död. När heroin och andra kortverkande opiater binder in till μ-opioidreceptorer i hjärnan sker en ökad frisättning av signalsubstansen dopamin och en stark känsla av eufori infinner sig. Vid upprepat intag sker förändringar i hjärnan; belöningseffekten minskar medan antibelöningseffekterna ökar och cravings och abstinensymptom blir allt tydligare vid frånvaro av drogen. Vid läkemedelsassisterad rehabilitering vid opiatberoende (LARO) används förutom psykosocial behandling även långverkande opio

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Eriksson, Frida, and Marika Bjärgestad. "Sjuksköterskors attityder till smärtbehandling för opioidberoende patienter : en litteraturöversikt." Thesis, Sophiahemmet Högskola, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-3953.

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Bakgrund Smärta är en subjektiv upplevelse och smärtbehandling bör därför utformas olika beroende på individens smärtupplevelse. Att lindra lidande och smärtbehandla alla patienter där behovet finns är en del av sjuksköterskans arbetsuppgifter. Smärtbehandling hos patienter med ett samtidigt opioidberoende kan upplevas problematiskt och som ett hinder i vårdandet av denna patientgrupp. Sjuksköterskors attityder till att smärtbehandla opioidberoende patienter kan grunda sig i egna erfarenheter och personliga åsikter där attityden kan påverka mötet med patienter och vårdande

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Wittchen, Hans-Ulrich, Sabine M. Apelt, Michael Soyka, et al. "Feasibility and outcome of substitution treatment of heroin-dependent patients in specialized substitution centers and primary care facilities in Germany: A naturalistic study in 2694 patients." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-110756.

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Background: In many countries, buprenorphine and methadone are licensed for the maintenance treatment (MT) of opioid dependence. Despite many short-term studies, little is known about the long-term (12-month) effects of these treatments in different settings, i.e. primary care-based (PMC) and specialized substitution centers (SSCs). Objectives: To describe over a period of 12 months: (1) mortality, retention and abstinence rates; (2) changes in concomitant drug use, somatic and mental health; and (3) to explore differences between different types of provider settings. Methods: 12-Month prosp

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MacVicar, Sonya. "IBriS study : intervention supporting breastfeeding in substance dependency." Thesis, Robert Gordon University, 2016. http://hdl.handle.net/10059/2119.

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Introduction: Breastfeeding offers the substance exposed mother and child potential short and long-term health benefits, with breast milk shown to alleviate the severity of Neonatal Abstinence Syndrome. Substance dependent women, however, have limited success establishing breastfeeding with physical, psychological and institutional factors cited as barriers. This study aimed to develop and test the feasibility of an evidence informed and theory based intervention to support continued breastfeeding for this group. Methods: The research was a two-phase feasibility study. Phase 1 informed interve

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Botros, Milad. "Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways." Doctoral thesis, Uppsala universitet, Avdelningen för biologisk beroendeforskning, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9401.

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Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. [3H]-SP(1-7) specifically binds to high affinity binding sites identified as receptor targets for the heptapeptide SP (1-7). Two distinct binding sites were observed in the spinal cord. One site is recognized by high affinity for SP(1-7) with a Kd of 0.5 nM, whereas the other site

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40

Chamberlain, Jude M. "Development of an MMPI-2 Scale to Aid in Assessing Opioid Use Disorder." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1398255420.

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Greenwell, David Morgan. "A study of readiness to change, self efficacy and treatment entry pressures in people undertaking methadone maintenance treatment for opioid dependence." Thesis, Glasgow Caledonian University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.688295.

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Brooks, Billy. "Rural Opioid and Other Drug Use Disorder Diagnosis: Assessing Measurement Invariance and Latent Classification of DSM-IV Abuse and Dependence Criteria." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2569.

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The rates of non-medical prescription drug use in the United States (U.S.) have increased dramatically in the last two decades, leading to a more than 300% increase in deaths from overdose, surpassing motor vehicle accidents as the leading cause of injury deaths. In rural areas, deaths from unintentional overdose have increased by more than 250% since 1999 while urban deaths have increased at a fraction of this rate. The objective of this research was to test the hypothesis that cultural, economic, and environmental factors prevalent in rural America affect the rate of substance use disorder (

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Wittchen, Hans-Ulrich, Sabine M. Apelt, Michael Soyka, et al. "Feasibility and outcome of substitution treatment of heroin-dependent patients in specialized substitution centers and primary care facilities in Germany: A naturalistic study in 2694 patients." Technische Universität Dresden, 2008. https://tud.qucosa.de/id/qucosa%3A26834.

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Background: In many countries, buprenorphine and methadone are licensed for the maintenance treatment (MT) of opioid dependence. Despite many short-term studies, little is known about the long-term (12-month) effects of these treatments in different settings, i.e. primary care-based (PMC) and specialized substitution centers (SSCs). Objectives: To describe over a period of 12 months: (1) mortality, retention and abstinence rates; (2) changes in concomitant drug use, somatic and mental health; and (3) to explore differences between different types of provider settings. Methods: 12-Month prosp

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Sheu, Ming-Jyh. "Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels and opioid receptors in central nervous system /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu148786498660922.

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Hong, Pil-Sung, and Anders Kjell. "Smärtlindring av patienter med opiatberoende : En kvalitativ intervjustudie med sjuksköterskor verksamma inom beroendevård." Thesis, Röda Korsets Högskola, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-538.

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Bakgrund: Internationell forskning visar på problematik kring smärtlindring av patienter med opiatberoende. Det framkommer att otillräckliga doser analgetika administreras till denna patientgrupp och att vårdpersonal saknar kunskap gällande smärtlindring av patienter med opiatberoende. Forskning visar även att vårdpersonal kan ha en negativ inställning till drogberoende patienter och ofta misstror deras motiv gällande förfrågan om analgetika. Vidare visar forskningen att denna patientgrupp upplever sig få en sämre vård än patienter utan drogberoende. Syfte: Studiens syfte var att belysa faktor

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Duah, Akwasi. "Lived Experience of Caregivers of Relatives with Alcohol and Opiate Dependence (A phenomenological study)." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsn_diss/50.

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Substance abuse is a relapsing chronic illness. In 2014, an estimated 27 million persons reported using illicit drugs in the United States (SAMHSA, 2014). Substance abuse negatively impacts societies, productivity, healthcare costs and families. Families play an important role in relapse prevention and sobriety. With adequate family support, substance abuse positively responds to treatment. Many individuals (about 66 million Americans) play the role as an informal caregiver for a relative with chronic illnesses such as substance abuse but few studies exist on the caregiving experiences. What w

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Slatvickaja, Nelė. "Opioidinės priklausomybės pacientų lūkesčių tenkinimas slaugos procese." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130607_114752-92706.

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Lietuvoje asmenims, priklausomiems nuo opioidų, vis dažniau yra skiriamas gydymas stacionaruose ir farmakoterapija metadonu ar buprenorfinu. Tokiems pacientams visą parą skiriama slauga, todėl siekiant tobulinti slaugos paslaugų kokybę, svarbu žinoti, kaip slaugos veiksnius vertina patys pacientai, priklausomi nuo opioidų, ir slaugytojai, dirbantys priklausomybės ligų centruose, kokie slaugos veiksniai turi teigiamą arba neigiamą poveikį slaugos procesui ir pacientų lūkesčiams. Darbo tikslas. Išanalizuoti opioidinės priklausomybės pacientų lūkesčių tenkinimą slaugos procese. Tyrimo metodika. A

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LaForge, Karl Steven. "Preproenkephalin Gene and mRNA : Studies of Structure, Function, Cocaine Responses in an Animal Model, and Genetic Association with Human Opiate Addiction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4013.

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Steensland, Pia. "Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5192-6/.

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Delorme, Jessica. "Évaluation de la douleur et du mésusage de la buprénorphine et de la méthadone chez les patients dépendants aux opioïdes substitués." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS023.

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La dépendance aux opioïdes est un problème majeur de santé publique dont la prévalence et l’incidence ne cessent d’augmenter. Sa prise en charge pharmacologique repose sur une approche substitutive basée sur la prescription des médicaments de substitution aux opioïdes (MSO), buprénorphine (BHD) et méthadone (MTD), commercialisés depuis 1995-1996 en France. Leur efficacité clinique a largement été démontrée en réduisant la consommation d’héroïne, la mortalité par overdose et en améliorant la qualité de vie des patients. Néanmoins, en parallèle, des problématiques en lien avec le mésusage des MS

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