Gotowe bibliografie tematyczne / Optical replication mapping

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Gotowa bibliografia na temat „Optical replication mapping”

Autor: Grafiati

Data publikacji: 5 października 2024

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Optical replication mapping"

Wang, Weitao, Kyle N. Klein, Karel Proesmans, et al. "Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication." Molecular Cell 81, no. 14 (2021): 2975–88. http://dx.doi.org/10.1016/j.molcel.2021.05.024.

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Lacroix, Joris, Sandrine Pélofy, Charline Blatché, et al. "Analysis of DNA Replication by Optical Mapping in Nanochannels." Small 12, no. 43 (2016): 5963–70. http://dx.doi.org/10.1002/smll.201503795.

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Bayard, Quentin, Pierre Cordier, Camille Péneau, et al. "Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma." Cancer Research 82, no. 8 (2022): 1470–81. http://dx.doi.org/10.1158/0008-5472.can-21-3665.

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Abstract Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole-genome sequencing (WGS) to explore in depth the nature of structural variants (SV) induced by replication stress in cyclin-activated hepatocellular carcinomas (CCN-HCC). In addition to classical tandem duplications, CCN-HCC displayed frequent intra-chromosomal and interchromosomal templated insertion cycles (TIC), likely resulting from template switching events. Template switching preferentially involves active topologically associated domains that are proximal t

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Rhind, Nick, Weitao Wang, Kyle Klein, et al. "Single‐Molecule Optical Replication Mapping (ORM) Suggests Human Replication Timing is Regulated by Stochastic Initiation." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.03352.

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Bayard, Quentin, Pierre Cordier, Camille Péneau, et al. "Abstract LB545: Structure, dynamics and consequences of replication stress-induced structural variants in hepatocellular carcinoma." Cancer Research 82, no. 12_Supplement (2022): LB545. http://dx.doi.org/10.1158/1538-7445.am2022-lb545.

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Abstract Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole genome sequencing to explore in-depth the nature of structural variants (SVs) induced by replication stress in cyclin-activated hepatocellular carcinomas (CCN-HCC). In addition to classical tandem duplications, CCN-HCC display frequent intra- and inter-chromosomal templated insertion cycles (TIC) likely resulting from template switching events. Template switching preferentially involves active topologically associated domains that are close in the 3D genome organ

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Brewer, Bonita J., Maitreya J. Dunham, and M. K. Raghuraman. "A unifying model that explains the origins of human inverted copy number variants." PLOS Genetics 20, no. 1 (2024): e1011091. http://dx.doi.org/10.1371/journal.pgen.1011091.

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With the release of the telomere-to-telomere human genome sequence and the availability of both long-read sequencing and optical genome mapping techniques, the identification of copy number variants (CNVs) and other structural variants is providing new insights into human genetic disease. Different mechanisms have been proposed to account for the novel junctions in these complex architectures, including aberrant forms of DNA replication, non-allelic homologous recombination, and various pathways that repair DNA breaks. Here, we have focused on a set of structural variants that include an inver

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Li, Guozhuang, Nan Wu, Jen Ghabrial, et al. "Chromoanagenesis in Osteosarcoma." Biomolecules 15, no. 6 (2025): 833. https://doi.org/10.3390/biom15060833.

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Chromoanagenesis is a catastrophic genomic phenomenon involving sudden, extensive rearrangements within one or a few cell cycles. In osteosarcoma, the most prevalent malignant bone tumor in children and adolescents, these events dramatically alter the genomic landscape, frequently disrupting key tumor suppressor genes like TP53 and RB1, amplifying oncogene expression, and propelling tumor progression and evolution. This review elucidates how key chromoanagenic mechanisms, such as chromothripsis and chromoanasynthesis, arise from replication stress and impaired DNA repair pathways, ultimately c

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De Carli, Francesco, Nikita Menezes, Wahiba Berrabah, Valérie Barbe, Auguste Genovesio, and Olivier Hyrien. "High-Throughput Optical Mapping of Replicating DNA." Small Methods 2, no. 9 (2018): 1800146. http://dx.doi.org/10.1002/smtd.201800146.

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Atkinson, Noah, Tyler A. Morhart, Garth Wells, et al. "Microfabrication Process Development for a Polymer-Based Lab-on-Chip Concept Applied in Attenuated Total Reflection Fourier Transform Infrared Spectroelectrochemistry." Sensors 23, no. 14 (2023): 6251. http://dx.doi.org/10.3390/s23146251.

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Micro electro-mechanical systems (MEMS) combining sensing and microfluidics functionalities, as are common in Lab-on-Chip (LoC) devices, are increasingly based on polymers. Benefits of polymers include tunable material properties, the possibility of surface functionalization, compatibility with many micro and nano patterning techniques, and optical transparency. Often, additional materials, such as metals, ceramics, or silicon, are needed for functional or auxiliary purposes, e.g., as electrodes. Hybrid patterning and integration of material composites require an increasing range of fabricatio

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Fearns, Rachel, Mark E. Peeples, and Peter L. Collins. "Mapping the Transcription and Replication Promoters of Respiratory Syncytial Virus." Journal of Virology 76, no. 4 (2002): 1663–72. http://dx.doi.org/10.1128/jvi.76.4.1663-1672.2002.

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ABSTRACT An important, unresolved issue in mononegavirus biology is whether or not transcription is initiated by the same promoter as RNA replication. In this study, residues important for respiratory syncytial virus (RSV) transcription and RNA replication were identified by subjecting the first 26 nucleotides of genome RNA to saturation mutagenesis. This analysis was performed using a genome analog that allowed transcription and RNA replication to be dissociated from each other and monitored as independent events in an intracellular assay. This analysis showed that nucleotides 3C, 5C, 8U, 9U,

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Rozprawy doktorskie na temat "Optical replication mapping"

Wang, Weitao. "Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication." Electronic Thesis or Diss., Université Paris sciences et lettres, 2021. http://www.theses.fr/2021UPSLS048.

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La réplication de l'ADN est régulée par l'emplacement et le moment de l'initiation de la réplication. Par conséquent, beaucoup d'efforts ont été investis dans l'identification et l'analyse des sites d'initiation de la réplication dans les cellules humaines. Cependant, la nature hétérogène de la cinétique de réplication eucaryote et la faible efficacité de l'utilisation du site d'initiation individuelle chez les métazoaires a rendu difficile la cartographie de l'emplacement et du moment de l'initiation de la réplication dans les cellules humaines. Une solution potentielle au problème de la cart

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Saulebekova, Dalila. "Study of DNA replication program of the human genome by high–throughput single-molecule Optical Replication Mapping." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS185.pdf.

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La réplication de l'ADN est un processus cellulaire crucial, qui garantit que chaque division cellulaire aboutit à une duplication précise du génome, composé de plus de 6 milliards de paires de bases chez l'homme. Ce processus repose sur l'activation précise de milliers d'origines de réplication dans un ordre temporel défini, appelé programme Replication Timing (RT). Ce programme est étroitement lié à l'organisation de la chromatine et sa dérégulation peut conduire à l'instabilité du génome, à des mutations et au développement des maladies telles que le cancer. Cependant, la nature hétérogène

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Menezes, Braganca Nikita. "Cartographie pangénomique à haut débit et en molécule unique de la réplication de l'ADN." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEE040.

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La réplication de l'ADN est un processus vital qui assure la transmission l'information génétique aux cellules filles. Chez les eucaryotes, la réplication du génome s'effectue en utilisant de multiples origines de réplication. Chez les métazoaires, la cartographie de la réplication demeure difficile. Les cartographies pangénomiques des origines de réplication chez l’Homme réalisées à l'aide de techniques de séquençage, ne s’accordent que modérément. Une explication possible de ces incohérences est que ces approches utilisent de grandes populations cellulaires qui ne nous donne qu’une image moy

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