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Artykuły w czasopismach na temat „Oral Soft-tissue Lesions; Oral squamous cell carcinoma”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Kalavathi, Lakshmi C., Krishna Vemuru Chaitanya, and Vydehi B. Venkata. "A bird's-eye view of pathologist over diagnostic confusion of oral cavity lesions." Journal of Oral and Maxillofacial Pathology 27, no. 2 (2023): 266–74. http://dx.doi.org/10.4103/jomfp.jomfp_312_22.

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Introduction: Oral cavity can be host to multitude of neoplastic, premalignant or non neoplastic pathological lesions. Diagnosis of lesions of oral cavity is always of interest to clinician and pathologist and rely on clinical appearance of lesions. There can be variation in diagnosis of clinical lesion with histopathology. Many oral carcinomas arise within the sites that previously had premalignant lesion. Incidence of oral cancers in population has increased among younger generations related to habits and lifestyle. These lesions during clinical presentation are misleading and create diagnos

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Bajracharya, Dipshikha, Sujaya Gupta, Bidhata Ojha, and Radha Baral. "Prevalence of Oral Mucosal Lesions in a Tertiary Care Dental Hospital of Kathmandu." Journal of Nepal Medical Association 56, no. 207 (2017): 362–66. http://dx.doi.org/10.31729/jnma.3283.

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Introduction: Oral mucosa can be affected by a variety of soft tissue lesions and conditions. Benign as well as malignant lesions of oral cavity are common. Squamous cell carcinoma is one of the commonest malignancies. The present retrospective study was undertaken to study the prevalence of various oral mucosal lesions in a tertiary care dental hospital of Kathmandu. Methods: This retrospective study was carried out in the Department of Oral and Maxillofacial Pathology at Kantipur Dental College and Teaching hospital from January 2015 to January 2017. The study included biopsy specimen

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Velayutham, Jeeven, Jeyasakthy Saniasiaya, and Mohd Zulkiflee Bin Abu Bakar. "Whitish Patch over Soft Palate: A Case Report of Incidental Finding of Basaloid Squamous Cell Carcinoma." Sumatera Medical Journal 6, no. 3 (2023): 177–83. http://dx.doi.org/10.32734/sumej.v6i3.13272.

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Abstract. Introduction: Whitish lesion over the oropharyngeal mucosal lesion is traditionally attributed to benign lesions such as leukoplakia, oral candidiasis or lichen planus, which can be diagnosed through histopathological examination. Yet, performing a biopsy is prudent in all cases of persistent whitish lesions to rule out a more sinister pathology such as malignancy. Herein, we report an incidental finding of a whitish lesion in the soft palate of a gentleman who presented with otalgia and otorrhea, which turned out to be basaloid squamous cell carcinoma (BSCC). Therefore, we highlight

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Ghanghoria, S., A. Ghanghoria, and A. Shukla. "p53 Expression in Oral cancer: A study of 50 cases." Journal of Pathology of Nepal 5, no. 9 (2015): 747–51. http://dx.doi.org/10.3126/jpn.v5i9.13785.

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Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion.Materials and Methods: Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma,

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Afradi, Zohreh, Layla Panahipour, Salman Abbas Zadeh, and Reinhard Gruber. "PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells." Bioengineering 11, no. 8 (2024): 746. http://dx.doi.org/10.3390/bioengineering11080746.

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Platelet-rich fibrin (PRF), originally used to support soft tissue healing, is also considered a therapeutic option for treating oral lichen planus and leukoplakia. The progression from the two premalignant lesions to the aggressive malignant oral squamous cell carcinoma involves an inflammatory process linked to chemokine expression. Thus, there is a rationale for studying how PRF modulates the expression of chemokines in oral squamous carcinoma cells. To this aim, we expose the oral squamous carcinoma cell line HSC2 to IL1β and TNFα either alone or in the presence of lysates obtained from so

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6

Hange, Venkatesh. "Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report." Journal of Scientific Research in Medical and Biological Sciences 1, no. 2 (2020): 133–39. http://dx.doi.org/10.47631/jsrmbs.v1i2.40.

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Carcinoma of lip develops due to formation of malignant cells in the lips and it is the most common site for squamous cell carcinoma (SCC) in the head and neck region. Oral cavity is among top five leading sites of cancer, regardless of gender distribution across India. Squamous cell carcinoma of lip occurs at myriad locations along the upper or lower lip or commissure of lip, but majority (80% to 95%) of cases are seen on the lower lip region. Majority of oral cavity carcinoma cases (> 90%) are seen in patients above the age of 45, having a male predilection in distribution. Lesions that i

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7

Mubarak, Sana, Shazia Akbar, Bhunesha Devi, Uzma Tariq, and Ambreen Junaid. "Demographic Spectrum of Oral Squamous Cell Carcinoma in Public Health Care Facility in Karachi Pakistan." Pakistan Journal of Medical and Health Sciences 16, no. 7 (2022): 505–7. http://dx.doi.org/10.53350/pjmhs22167505.

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Objective: The aim of this study was to evaluate the spread and proportion of oral squamous cell carcinoma in oral lesions. Methods: Patient’s biopsies were collected from january2017 till July2017 from histopathology lab in public health care institute. Two types of specimens either submitted for diagnosis or post-operative analysis of the lesion were reported. The data of oral tissue biopsies was analyzed and cases were sorted on the basis of benign and malignant lesions. The incidence of cancer and benign lesions was reported as; gender, age and site. Results: Moderately differentiated hist

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Dahal, Mona, Smriti Karki, Paricha Upadhyaya, Shyam Thapa Chettri, and Mehul Rajesh Jaisani. "Role of p53 and Ki-67 immunomarkers in oral premalignant lesions and squamous cell carcinoma: a hospital based study in BPKIHS." Journal of Pathology of Nepal 8, no. 2 (2018): 1330–36. http://dx.doi.org/10.3126/jpn.v8i2.20861.

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Background: As most of the oral squamous cell carcinoma develop from precursor premalignant lesions, it would be helpful if the malignant transformation is detected early in premalignant state. The objective of the research was to study the role of immunohistochemical expression of p53 and Ki-67 in oral premalignant lesion and squamous cell carcinoma.Materials and Methods: The expression of immunomarkers p53 and Ki67 were studied on formalin fixed paraffin embedded tissue sections from human oral squamous mucosal lesion for duration of 1 year. Results: Of total 36 cases, 80% cases of keratosis

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9

Narayana, Nagamani, Julie Gist, Tyler Smith, Daniel Tylka, Gavin Trogdon, and James K. Wahl. "Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma." Dermatology Research and Practice 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/649731.

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Squamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded by premalignant disease that appears histologically as dysplasia. Identification of molecular markers for cellular change would assist in determining the risk of dysplasia progressing to oral squamous cell carcinoma. The goal of this study was to determine if any correlation exists between histologic

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10

Panahipour, Layla, Rebecca Croci, Sara Guarnieri, and Reinhard Gruber. "PRF Lysates Enhance the Proliferation and Migration of Oral Squamous Carcinoma Cell Lines." Dentistry Journal 11, no. 10 (2023): 242. http://dx.doi.org/10.3390/dj11100242.

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Platelet-rich fibrin (PRF) is an autologous fibrin-rich matrix where activated platelets and leucocytes accumulate. PRF has a wide spectrum of clinical indications with the overall aim of supporting tissue regeneration which in dentistry includes the healing of healthy oral mucosa with epithelial cells. In oral squamous cell carcinoma lesions, however, epithelial cells undergo malignant transformation, indicated by their unrestricted proliferation and migration potential, which should not be further enhanced by a wound-healing formula. Yet, little is known about how oral squamous cell carcinom

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11

Abidullah, Mohammed, Bushra Anjum, Shaikh Mohammed Imran Saudagar, Swathi Jahagirdar, Peddisetty Govind Raj Pankaj Mallik, and Mediconda Shivaratna. "Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis." Journal of Pharmacy and Bioallied Sciences 16, Suppl 5 (2024): S4765—S4768. https://doi.org/10.4103/jpbs.jpbs_920_24.

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ABSTRACT Aim: Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis. Materials and Methods: The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM). Results: In the current investigation, a comparison was made between toluidine blue stained sections of normal oral mucosa, oral epithelial dysplasia and OSCC. The resultant P value was determined to b

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12

Ilyas, Syafruddin. "Oral Squamous Cell Carcinoma: The Molecular Characteristics." International Journal of Ecophysiology 4, no. 2 (2022): 52–57. http://dx.doi.org/10.32734/ijoep.v4i2.11389.

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Oral squamous cell carcinoma (OSCC) is a malignancy that occurs on keratinocyte cells that have the potential to spread through lymphatic tissue or blood vessels. These carcinomas develop as a result of a series of molecular factors, which are influenced by individual genetic factors as well as environmental exposure to carcinogens. The evaluation of the prognosis and treatment plan for OSCC are mainly based on the clinical picture of the tumor or the TNM classification (T, tumor; N, lymph nodes or glands; M, metastases). The disadvantage of this diagnostic technique is that it does not consid

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13

Femilian, Afryla, Afina Hasnasari Heningtyas, and Dwi Suhartiningtyas. "The Training and Empowerment of Health Cadres in Early Detection of Oral Cancer with SAMURI in Margodadi Seyegan." Proceeding International Conference of Community Service 1, no. 1 (2023): 277–81. http://dx.doi.org/10.18196/iccs.v1i1.33.

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Premalignant lesions are morphologically altered tissues, more likely to develop cancer. Premalignant lesions are more commonly expressed as a general condition associated with a significant risk of cancer. These lesions can appear in the oral cavity. Oral lichen planus, submucosal oral fibrosis, and leukoplakia are premalignant mucosal lesions that have the potential to become malignant in the oral cavity in the development of oral squamous cell carcinoma. Public health cadres are men or women selected by the community and trained to deal with individual and community health problems to work

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14

Kasapa, Shyam Sunder. "Immunohistochemical Analysis of P53 Protein Expression in Oral Lesions." International Journal of Toxicological and Pharmacological Research 13, no. 6 (2023): 44–52. https://doi.org/10.5281/zenodo.11122586.

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<strong>Background:</strong> The oncoprotein p53 actively contributes to the initiation and/or development of oral carcinogenesis. It has been demonstrated that many human solid tumors of squamous origin, including oral squamous cell carcinomas, express mutant p53. The current study aimed to determine the expression of p53 in oral cavity lesions and its associations with tobacco use, including eating betel nuts with or without tobacco. <strong>Methods: </strong>Tissue samples from cases of Cases that exhibit leukoplakia, erythroplakia, mucosal ulcer, and growth were obtained. A

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15

Ghosh, Snehashish, Sartaj Singh Wazir, Rajesh Shah, Manoj Kumar Upadhyay, Rahul Gupta, and Harendra Mohan Singh. "Detection of Human Papilloma Virus in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma." Journal of College of Medical Sciences-Nepal 17, no. 3 (2021): 279–85. http://dx.doi.org/10.3126/jcmsn.v17i3.38765.

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Introduction: Human Papilloma Virus 16 and 18 affects the keratinocytes of oral mucosa and skin and can lead to the development of dysplastic lesions and ultimately into invasive oral squamous cell carcinoma. The objective of the present study was to evaluate the presence of human Papilloma virus 16 and 18 DNA in already diagnosed oral potentially malignant disorders and oral squamous cell carcinoma. Methods: 200 biopsy specimens (50 each) of already diagnosed leukoplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF) and oral squamous cell carcinoma was included for the study. A to

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Bregman, C. L., R. S. Hirth, J. P. Sundberg, and E. F. Christensen. "Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine." Veterinary Pathology 24, no. 6 (1987): 477–87. http://dx.doi.org/10.1177/030098588702400602.

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A spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (COP) vaccine, suggesting a viral etiology for the masses. Lesions included epidermal hyperplasia, epidermal cysts, squamous papilloma, basal cell epithelioma, and squamous cell carcinoma. Peroxidase-antiperoxidase staining of tumor sections revealed nuclei which stained for group-specific papillomavirus antigen in five of 12 masses. Electron microscopic examination of tumor sections did not reveal virions. In transmission studies, macerated tumor tissue did not produce or

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Raza, Syeda Hala, Sufyan Ahmed, and Maryam Zafar. "Spectrum of biopsied oral and maxillofacial lesions in a tertiary care hospital of Karachi, Pakistan." Journal of Fatima Jinnah Medical University 15, no. 2 (2021): 81–86. http://dx.doi.org/10.37018/mtrk5234.

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Objectives: The burden of benign and malignant maxillofacial lesions in developing countries has increased rapidly over the years. Objective of this study was to provide a spectrum of oral and maxillofacial lesions biopsied in a tertiary care hospital of Karachi, Pakistan and to contribute in baseline data of target population. Patients and methods: This descriptive cross sectional study was made of biopsies performed in patients presenting to OPD of Oral and Maxillofacial Surgery Department, Abbasi Shaheed Hospital Karachi, Pakistan, between July 2018 till June 2020. A total of 652 pati

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Song, Xiaowei, Xihu Yang, Rahul Narayanan, et al. "Oral squamous cell carcinoma diagnosed from saliva metabolic profiling." Proceedings of the National Academy of Sciences 117, no. 28 (2020): 16167–73. http://dx.doi.org/10.1073/pnas.2001395117.

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Saliva is a noninvasive biofluid that can contain metabolite signatures of oral squamous cell carcinoma (OSCC). Conductive polymer spray ionization mass spectrometry (CPSI-MS) is employed to record a wide range of metabolite species within a few seconds, making this technique appealing as a point-of-care method for the early detection of OSCC. Saliva samples from 373 volunteers, 124 who are healthy, 124 who have premalignant lesions, and 125 who are OSCC patients, were collected for discovering and validating dysregulated metabolites and determining altered metabolic pathways. Metabolite marke

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Oliveira, Christiane Fátima, Lucas Antônio Lisboa Ribeiro, Kamilla Monteiro dos Santos Dias, Marco Aurélio Benini Paschoal, Brayan Jonas Mano-Sousa, and Joaquim Mauricio Duarte-Almeida. "Efficacy of green propolis in the treatment of oral squamous cell carcinoma: a case report." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 18, no. 2 (2025): e15592. https://doi.org/10.55905/revconv.18n.2-255.

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Oral cancer is a malignant neoplasm that affects several oral structures. Its main risk factors include tobacco use, excessive alcohol consumption, poor oral hygiene, restricted diet, and HPV infection. Men over 50 years old, especially smokers and alcohol drinkers, are most affected. Squamous cell carcinoma (SCC) represents 90% to 95% of cases and is characterized by persistent ulcers with persistence and peripheral infiltration. Biopsy is essential for diagnosis, which can be complemented by imaging tests and biomarker analysis. Recent studies have explored the use of natural products, such

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Ambarkova, Vesna. "Oral and Dental Manifestations of Fanconi Anemia." Galician Medical Journal 28, no. 3 (2021): E202132. http://dx.doi.org/10.21802/gmj.2021.3.2.

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Fanconi anemia is a rare disease, which is characterized by decreased production of all blood cell types. Fanconi anemia is the most common inherited form of aplastic anemia. Congenital abnormalities of the eyes, ears, and heart, malformed or absent kidney, urogenital system involvement are common. There is a delay in physical development. Intelligence in patients with Fanconi anemia is usually normal. The most serious problems associated with Fanconi anemia include the gradual development of bone marrow disorders. Many patients with Fanconi anemia develop leukemia or myelodysplastic syndrome,

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Sundararajan, Amutha, Rajmohan Muthusamy, Kumar Gopal Siva, Prasad Harikrishnan, Sri Chinthu Kenniyan Kumar, and Selva Kumar Rathinasamy. "Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma." Rambam Maimonides Medical Journal 12, no. 2 (2021): e0016. http://dx.doi.org/10.5041/rmmj.10438.

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Objective: The aim of this study was to compare and correlate mast cell density (MCD) and microvessel density (MVD) between normal oral mucosa, oral lichen planus, various grades of dysplasia, and oral squamous cell carcinoma (OSCC). Materials and Methods: The study comprised a total of 75 samples, of which 65 were archival tissue blocks of histopathologically confirmed cases, which included 10 cases of oral lichen planus, 25 cases of dysplasia (mild [n=10], moderate [n=10], and severe [n=5]), and 30 cases of OSCC (well differentiated [n=10], moderately differentiated [n=10], and poorly differ

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Mijoska, Aneta, Gordana Kovacevska, and Georgi Tomov. "ORAL TISSUE CONDITION IN PROSTHODONTIC GERIATRIC PATIENTS." Teacher of the future 31, no. 4 (2019): 865–68. http://dx.doi.org/10.35120/kij3104865m.

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The world population is continuously getting older in developed and undeveloped countries. According to WHO over 20% of the population in Europe is over 65 years old. Geriatric population in North Macedonia is presented with 16% and with high prevalence of anodontia over 45, 1%, poor oral hygiene and urgent demand of prosthodontics treatment. Aging is a process with different and specific changes of all systems and organs, including the orophacial system. In this population, the number of remaining teeth is evidently reduced, their condition has changed, and soft and hard oral tissues are affe

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Sharma, SC, Veena Maheshwari, Varsha Narula, Sachin Verma, Anshu Jain, and Kiran Alam. "Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity." International Journal of Head and Neck Surgery 4, no. 2 (2013): 61–65. http://dx.doi.org/10.5005/jp-journals-10001-1141.

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ABSTRACT Introduction Oral squamous cell carcinoma, the fifth most common cancer worldwide, is a major cause of morbidity and mortality in India. It most commonly occurs in middle-aged and older individuals. Typically, they tend to be preceded by a premalignant state for a long time. The present study evaluates the clinicopathological profile of patients with oral lesions and the role of malpractices that promote carcinogenesis in the oral mucosa and the use of Ki-67 as an important predictor of the same. Materials and methods The expression of Ki-67 was studied in paraffin-embedded tissue sec

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Nelonda, Revi, and Riani Setiadhi. "Management of chronic traumatic ulcer mimicking oral squamous cell carcinoma on the tongue." Dental Journal (Majalah Kedokteran Gigi) 51, no. 2 (2018): 76. http://dx.doi.org/10.20473/j.djmkg.v51.i2.p76-80.

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Background: Traumatic ulcers represent the most common oral mucosal lesions that can be differentiated from oral squamous cell carcinoma (OSCC) by their clinical appearance. From a clinical perspective, OSCC may resemble a chronic traumatic ulcer (CTU) because the base of the CTU that is healing is filled with reddish-pink granulated tissue, similar to that in OSCC. Purpose: The aim of this case report is to provide information about the oral management of a CTU case that imitates OSCC. Case: A 30-year old female presented with a major, painful, non-healing ulcer located on the right lateral o

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Dr, Kedar Kawsankar, Harish Saluja Dr, Seemit Shah Dr, et al. "Involvement of Submental Lymph Node in Oral Squamous Cell Carcinoma (OSCC)." Involvement of Submental Lymph Node in Oral Squamous Cell Carcinoma (OSCC) 8, no. 10 (2023): 5. https://doi.org/10.5281/zenodo.10099196.

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Background: Squamous cell carcinoma (OSCC) is one of the most common malignancies of oral cavity. Metastasis of oral squamous cell carcinoma (OSCC) is a complex process involving detachment of cells from the tumor tissue, regulation of cell motility and invasion, proliferation and evasion through the lymphatic system or blood vessels. The metastasis may affect the prognosis. 1Since not only the suppression of primary lesion but also the presence or absence of metastasis in the cervical lymph nodes may greatly influence the outcome of oral cancer. 2, 3The submental lymph nodes are categories as

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Mukherji, Soumyo, Sonal P. Vahanwala, Arvind Dhawangale, and Sourabh Agrawal. "Biopotential Assessment—An Alternative in Oral Squamous Cell Carcinoma Diagnostics: A Study." International Journal of Head and Neck Surgery 6, no. 4 (2015): 168–74. http://dx.doi.org/10.5005/jp-journals-10001-1248.

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ABSTRACT Aim: The aim of this study was to ascertain the relation between surface electrical potential and the presence of cancer in the buccal mucosa and their correlation. Materials and methods A device was designed to measure the skin potentials on the face, and various head and neck carcinomas can be detected in a noninvasive way. The present study is a case control study in the ratio 1:1, comprising two groups of 10 individuals each. The two distinct groups of the study are as follows: 1. Normal subjects group consisting of individuals with no habit of tobacco, with the absence of any les

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Tarashankar, Das, Saha Das Priyanka, Goswami Utpal, et al. "Assessment of P16INK4A Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma and Its Correlation with the Histological Grade of the Tumour." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 148–58. https://doi.org/10.5281/zenodo.14249113.

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<strong>Background:</strong> The objective of current study is to evaluate the role of HPV-16 in the pathogenesis of oral epithelial dysplasias (OED) and oral squamous cell carcinoma (OSCC) by immunohistochemistry (IHC) and to know whether HPV-16 participates in disruption of the regulation of p16 INK4A suppressor protein in OED and OSCC by IHC. <strong>Methodology:</strong> The present prospective study was done at Department of Pathology, ICARE Institute of Medical Sciences and Research and Dr. B.C.Roy Hospital, Haldia between the periods of December 2022 to May 2024 with a sa

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Jeyasivanesan, Dhana Lakshmi, and Ramakrishnan Bharathi. "Hidden vegetable matter in tissue sections – A case series." Journal of Oral and Maxillofacial Pathology 28, no. 1 (2024): 119–24. http://dx.doi.org/10.4103/jomfp.jomfp_408_23.

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Food particles get frequently impacted in the oral cavity in varying sites. Oral pulse granuloma develops as a consequence of implantation of food particles of plant or vegetable origin in oral tissues. The lesion might be central or peripheral. It has a differing histological picture and may be confused with many other lesions including parasitic infection. Impacted vegetable matter is rarely associated with multiple myeloma, bacterial and fungal osteomyelitis, and squamous cell carcinoma and has never been reported in the literature before. Thus, in the present case series, we have discussed

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Jacob, Navya, Murali T V, Indu M, and Amilu Elsa Varghese. "Ossifying Fibroma with Co-existent Squamous Cell Carcinoma in Maxilla." Bengal Journal of Otolaryngology and Head Neck Surgery 32, no. 2 (2025): 113–17. https://doi.org/10.47210/bjohns.2024.v32i2.139.

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INTRODUCTION: Ossifying fibroma is a rare benign bone lesion characterized by gradual development and asymptomatic presentation, typically affecting craniofacial bones in individuals, particularly females, during their second to fourth decades of life. The concurrent occurrence of oral squamous cell carcinoma (OSCC) with ossifying fibroma is exceedingly rare, with only one previous case reported. CASE REPORT: We describe a 71-year-old male presenting with a gradually enlarging swelling in the oral cavity, initially treated five years prior for a mandibular fracture. Clinical examination reveal

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Bsoul, Samer A., Geza T. Terezhalmy, and Michaell A. Huber. "Squamous Cell Carcinoma of the Oral Tissues: A Comprehensive Review for Oral Healthcare Providers." Journal of Contemporary Dental Practice 6, no. 4 (2005): 1–16. http://dx.doi.org/10.5005/jcdp-6-4-1.

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Abstract North Americans in 2004 were projected to die from oral and pharyngeal cancer at a rate of 1.2 per hour. Oral healthcare providers can be instrumental in reducing the incidence of oral and pharyngeal premalignant and malignant lesions by identifying patients with high-risk behavior, educating their patients about the consequences of their high-risk behavior, and by early detection of premalignant and malignant conditions. The fact only 34% of the cancers of the oral cavity and larynx are localized at the time of diagnosis and evidence that at least one third of the patients diagnosed

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Nelonda, Revi, and Tenny Setiani Dewi. "PENTINGNYA MENDETEKSI ORAL LEUKOPLAKIA SEBAGAI ORAL POTENTIALLY MALIGNANT DISORDERS (LAPORAN KASUS)." B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah 5, no. 2 (2019): 162–69. http://dx.doi.org/10.33854/jbd.v5i2.162.

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Oral Leukoplakia (OL) is white plaque lesion in oral mucosa thatcannot be scraped and one of Oral Potentially Malignant Disorder(OPMD) with incidence about 2.5% of all populations in the world.The most case of oral squamous cell carcinoma are preceded byOPMD. The aim of this case report is to understand the importance ofdetection oral lesion that could potentially become malignancy. A 28-year-old male patient complained of sores on his tongue that had nothealed for 2 months. Intraoral examination obtained red and whitelesion on the left lateral tongue: shallow reddish ulcer with irregularborde

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Vaibhav, Patel, Patel Himani, and Joshi Meghavi. "Prognostic Significance of p53 Mutation in Oral Premalignant and Malignant Lesions- a Tertiary Care Center Study." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 319–25. https://doi.org/10.5281/zenodo.11094587.

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<strong>Introduction:</strong> Oral cancers accounts for up to 40% of all malignancies in developing countries including India. Early detection and treatment play pivotal roles in improving prognosis and overall survival rates. p53 immunomarker could be considered complementary to conventional prognostic evaluation. <strong>Aim:</strong> The aim of present study is to analyse the expression of p53 in relation to histopathological diagnosis along with the utility of labelling Index of p53 protein in of oral premalignant and malignant lesions. Also, to evaluates clinicopathologica

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Rivera, César. "Histological and molecular aspects of oral squamous cell carcinoma (Review)." Oncology Letters 8, no. 1 (2014): 7–11. https://doi.org/10.3892/ol.2014.2103.

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Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancer, and over the last decade its incidence has increased by 50%. Oral carcinogenesis is a multistage process, which simultaneously involves precancerous lesions, invasion and metastasis. Degradation of the cell cycle and the proliferation of malignant cells results in the loss of control mechanisms that ensure the normal function of tissues. The aim of the current review is to present the histopathological features of OSCC, including potentially malignant changes, the international classification of tumors, th

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Zulijani, Ana, Andrea Dekanić, Tomislav Ćabov, and Hrvoje Jakovac. "Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions." Cancers 13, no. 18 (2021): 4530. http://dx.doi.org/10.3390/cancers13184530.

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This study aimed to assess the relationship and possible interactions between metallothioneins (MTs) and megalin (LRP-2) in different grades of oral squamous cell carcinoma (OSCC) and premalignant lesions of the oral mucosa (oral leukoplakia and oral lichen planus). The study included archived samples of 114 patients and control subjects. Protein expression was examined by immunohistochemistry and immunofluorescence, and staining quantification was performed by ImageJ software. Protein interaction in cancer tissue was tested and visualized by proximity ligation assay. Mann-Whitney and Kruskal-

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Amirchaghmaghi, Maryam, Nooshin Mohtasham, and Pegah Mosannen Mozaffari. "Comparison of COX2 Expression between Oral Squamous Cell Carcinoma, Leukoplakia and Normal Mucosa." Journal of Contemporary Dental Practice 13, no. 2 (2012): 205–9. http://dx.doi.org/10.5005/jp-journals-10024-1122.

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ABSTRACT Aim To compare cyclooxygenase 2 expression (COX2-E) between normal, oral leukoplakia lesions and different grades of oral squamous cell carcinoma (SCC). Materials and methods Around 90 paraffin embedded blocks consisting of 45 SCC, 15 leukoplakia and 17 controls were selected for immunohistochemistry (IHC) for detection of COX2- E. COX2-E was divided in four grades, as A (0-10%), B (11-40%), C (41-70%) and D (> 70%) cellularity. Results Mean age of the patients was 55.17 ± 18.41 (M:57.92 ± 16.87, F:52.19 ± 19.74). A significant difference was found in COX2 expression between SCC to

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Bouguezz, Adel, Sameh Sioud, and Hajer Hentati. "Field Cancerization in Oral Cavity: A review." Journal of Clinical Case Studies Reviews & Reports 2, no. 3 (2020): 1–5. http://dx.doi.org/10.47363/jccsr/2020(2)127.

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Patients with head and neck squamous cell carcinoma (HNSCC) often develop multiple (pre) malignant lesions. This finding led to the field of the cancerization theory, which hypothesizes that the entire epithelial surface of the upper aerodigestive tract has an increased risk for the development of (pre) malignant lesions, because of multiple genetic abnormalities in the whole tissue region. Demonstration of alterations in histologically normal tumor-adjacent mucosa from HNSCC patients supported this hypothesis. Currently, the question has been raised whether multiple lesions develop independen

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Fine, Madeleine W., Samira Cheruku, Antonia Kolokythas, et al. "Abstract 694: Brush biopsy miRNA based oral squamous cell carcinoma detection and localization-overcoming barriers to classifier development." Cancer Research 85, no. 8_Supplement_1 (2025): 694. https://doi.org/10.1158/1538-7445.am2025-694.

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Abstract Cancers of the oral cavity arise from the surface tissues and, despite prominence of these sites, over 50% are not diagnosed until they are in advanced stage. Unfortunately, patients with advanced stage oral cancer have high mortality rates because treatments are usually not successful, complex and have high complication rates. Among the main reasons for delays in diagnosis of squamous cell carcinoma, which make up over 90% of oral cancers, is the resemblance of these lesions to benign lesions. Specifically, oral squamous cell carcinoma (OSCC) is often misdiagnosed as a benign process

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John, Jubin, and Vadlamudi Nagendra. "The emerging role of dynamic contrast enhanced mri in differentiation between various histologic subtypes of oral cavity squamous cell carcinoma." Multidisciplinary Science Journal 7, no. 8 (2025): 2025404. https://doi.org/10.31893/multiscience.2025404.

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Differentiating histologic subtypes and assessing tumor grade of oral squamous cell carcinoma using conventional contrast-enhanced MRI can be challenging. Newer advanced imaging MRI technique such as dynamic contrast-enhanced MRI (DCE-MRI) provides assessment of prognosis and malignant potential of tumor by studying tissue microcirculation and blood perfusion. This study aims to determine whether dynamic contrast-enhanced (DCE) perfusion MRI can distinguish between histologic subtypes of oral cavity squamous cell carcinoma (SCC). Sixty-two patients with newly diagnosed tumor lesions underwent

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Hooper, Samuel J., St-John Crean, Michael J. Fardy, et al. "A molecular analysis of the bacteria present within oral squamous cell carcinoma." Journal of Medical Microbiology 56, no. 12 (2007): 1651–59. http://dx.doi.org/10.1099/jmm.0.46918-0.

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In order to characterize the bacterial microbiota present within oral cancerous lesions, tumorous and non-tumorous mucosal tissue specimens (approx. 1 cm3) were harvested from ten oral squamous cell carcinoma (OSCC) patients at the time of surgery. Any microbial contamination on the surface of the specimens was eliminated by immersion in Betadine and washing with PBS. Bacteria were visualized within sections of the OSCC by performing fluorescent in situ hybridization with the universal oligonucleotide probe, EUB338. DNA was extracted from each aseptically macerated tissue specimen using a comm

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Vyhnalova, Tereza, Zdenek Danek, Daniela Gachova, and Petra Borilova Linhartova. "The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma." Microorganisms 9, no. 8 (2021): 1549. http://dx.doi.org/10.3390/microorganisms9081549.

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Dysbiosis in the oral environment may play a role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). This review aims to summarize the current knowledge about the association of oral microbiota with OSCC and to describe possible etiopathogenetic mechanisms involved in processes of OSCC development and progression. Association studies included in this review were designed as case–control/case studies, analyzing the bacteriome, mycobiome, and virome from saliva, oral rinses, oral mucosal swabs, or oral mucosal tissue samples (deep and superficial) and comparing the results in health

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Gaire, Deepshikha, Anil Dev Pant, Daisy Maharjan, and Usha Manandhar. "Spectrum of Oral Cavity Lesions and its Clinico-Histopathological Correlation." Nepal Journal of Health Sciences 1, no. 2 (2021): 42–47. http://dx.doi.org/10.3126/njhs.v1i2.42378.

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Introduction: Oral cavity lesions comprise a wide spectrum of diseases that varies from non-neoplastic to neoplastic. The clinical evaluation alone is insufficient for proper diagnosis in most cases. So, histopathological examination is the gold standard method for diagnosis and management of patients accordingly. Objective: The present study was done to evaluate the histopathological spectrum of oral cavity lesions and compare them in relation to age, sex, site, clinical features, risk factors, and clinical diagnoses. Methods: This prospective cross-sectional study enrolled 127 cases of oral

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Hande, Alka, Archana Sonone, Madhuri Gawande, Swati Patil, Aayushi Pakhale, and Shelley Durge. "Histomorphometric analysis of angiogenesis in oral submucous fibrosis and oral squamous cell carcinoma associated with oral submucous fibrosis." F1000Research 12 (September 1, 2023): 1082. http://dx.doi.org/10.12688/f1000research.134764.1.

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Background: Oral submucous fibrosis (OSMF), now worldwide acknowledged as the disease of “Southeast Asia and Indian subcontinent”, has the utmost malignant transformation prevalence amongst oral precancerous disorders. Increased vascularity that is neoangiogenesis has been observed in the superficial connective tissue region of pre-cancerous lesions showing dysplasia. This could be an initial occurrence of the carcinogenesis process. The aim of this study will be to analyse neoangiogenesis by examining immunoexpression of CD105 in OSMF, and OSCC with OSMF cases. Methods: The project will compr

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Kochurova, Ekaterina V., Vladimir N. Nikolenko, Olga I. Panferova, et al. "Expression of saliva biomarkers in patients with squamous cell carcinoma in various regions of the oral mucosa." Russian Journal of Dentistry 25, no. 1 (2021): 29–34. http://dx.doi.org/10.17816/1728-2802-2021-25-1-29-34.

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BACKGROUND: Oral fluid as a means for early detection and differential diagnosis of diseases of the oral mucosa and for assessing the overall somatic status of the body attracts the attention of researchers due to the non-invasiveness of material sampling and the exclusion of risks possible during blood analysis, as well as a simpler, compared with blood samples, material storage regime. AIM: The study aimed to evaluate the levels of oral fluid biomarkers of 170 patients with squamous cell carcinoma of the oral mucosa (RCC-MOP) depending on the localization of the oncopathology. MA

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Gupta, Vaibhav, Poonam Goel, Usha Agrawal, Neena Chaudhary, Garima Jain, and Deepak Gupta. "Bioimpedance a Diagnostic Tool for Tobacco-induced Oral Lesions – A Mixed Model Cross-sectional Study." Contemporary Clinical Dentistry 16, no. 2 (2025): 104–10. https://doi.org/10.4103/ccd.ccd_290_24.

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Introduction: Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer, and basal cell carcinoma. The current study aimed to validate and evaluate bioimpedance as a diagnostic tool for tobacco-induced oral lesions. Methodology: The study comprised 50 oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) tissue specimens for in vitro study and 320 subjects for in vivo study. Bioimpedance device prepared and calibrated. EIS measurements were done for t

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Fuentes, B., J. Duaso, D. Droguett, et al. "Progressive Extracellular Matrix Disorganization in Chemically Induced Murine Oral Squamous Cell Carcinoma." ISRN Pathology 2012 (August 29, 2012): 1–7. http://dx.doi.org/10.5402/2012/359421.

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Introduction. Oral squamous cell carcinoma (OSCC) is one of the ten most common cancers affecting the human population. Tumor pathogenesis implies a multistep process in which cells acquire features that enable them to become tumorigenic and ultimately malignant. The process of OSCC carcinogenesis can be reproduced in animal models, the OSCC induction with 4-nitroquinoline-1-oxide (4NQO) in mice is a widely used tool for studying tumor pathogenesis. Objective. The aim of the present study was to determine the progressive changes in basal lamina and connective tissue remodeling during 4NQO-indu

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Patekar, Deepali, Sachin C. Sarode, Gargi S. Sarode, and Pravin More. "Cyclin D1 and Nuclear Factor Kappa B Expression in Oral Squamous Cell Carcinoma, Oral Submucous Fibrosis, and Oral Squamous Cell Carcinoma Associated with Oral Submucous Fibrosis – An Analytical Cross-Sectional Study." Journal of Dental Research and Review 8, no. 2 (2021): 75–81. http://dx.doi.org/10.4103/jdrr.jdrr_153_20.

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Background: According to statistics, oral squamous cell carcinoma (OSCC) is regarded as commonest cancer of the oral and maxillofacial region, having about 83% prevalence over the recent years. The prognostic accuracy of the cancer is determined by the stage of its detection and the onset of treatment. Expression of certain immunohistochemical markers such as cyclin Dl and nuclear factor kappa B (NF-κB) and their role in prognosis at an early stage would alter the treatment planning of such cases. Aim and Objectives: To assess and determine cyclin D1 and NF-κB expression using immunohistochemi

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Dowthwaite, S., C. Szeto, B. Wehrli, et al. "Contact endoscopy as a novel technique in the detection and diagnosis of oral cavity and oropharyngeal mucosal lesions in the head and neck." Journal of Laryngology & Otology 128, no. 2 (2014): 147–52. http://dx.doi.org/10.1017/s0022215113003332.

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AbstractObjective:We aimed to investigate the diagnostic accuracy of contact endoscopy in evaluating oral and oropharyngeal mucosal lesions.Methods:Between January 2010 and December 2011, 34 patients with lesions of the oral and oropharyngeal mucosa were enrolled in the study. Comparison between initial contact endoscopy results and ‘gold standard’ tissue biopsy was undertaken.Results:Nine patients had histologically confirmed squamous cell carcinoma, 2 had carcinoma in situ, 3 had dysplastic lesions and 20 patients had various benign lesions. Contact endoscopy demonstrated sensitivity and spe

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Baad, Rajendra, Sushma Bommanavar, Sonam C. Kapse, Nanita Rathod, Jyoti Mandlik, and Anupam S. Sharma. "Quantitative Assessment of Myofibroblast in Severe Dysplasia, Microinvasion and Oral Squamous Cell Carcinoma: An Immunohistochemical Study." Journal of Contemporary Dental Practice 14, no. 1 (2013): 34–38. http://dx.doi.org/10.5005/jp-journals-10024-1265.

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ABSTRACT Myofibroblast are essential for the integrity of human body by virtue of its role in wound healing and pathological organ remodeling. Myofibroblast is a universal cellular component in mammalian lesions, but not a typical component of normal untraumatized tissues. Therefore its presence in abundance in case of cancer is a matter of concern. Tumor microenvironment plays a pivotal role in tumor progression. These so called cancer associated fibroblast or myofibroblast are the major components and occur in stromal tissue during carcinogenesis processes. This study is a quantitative asses

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Kudo, Tomoo, Yoshihito Shimazu, Hisao Yagishita, et al. "Three-Dimensional Reconstruction of Oral Tongue Squamous Cell Carcinoma at Invasion Front." International Journal of Dentistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/482765.

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We conducted three-dimensional (3D) reconstruction of oral tongue squamous cell carcinoma (OTSCC) using serial histological sections to visualize the architecture of invasive tumors. Fourteen OTSCC cases were collected from archival paraffin-embedded specimens. Based on a pathodiagnostic survey of whole cancer lesions, a core tissue specimen (3 mm in diameter) was dissected out from the deep invasion front using a paraffin tissue microarray. Serial sections (4 μm thick) were double immunostained with pan-cytokeratin and Ki67 antibodies and digitized images were acquired using virtual microscop

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Baquero, Jorge, Xiao-Han Tang, Theresa Scognamiglio, and Lorraine J. Gudas. "EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas." Carcinogenesis 42, no. 12 (2021): 1485–95. http://dx.doi.org/10.1093/carcin/bgab091.

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Abstract Oral squamous cell carcinoma (oral SCC) is an aggressive disease and despite intensive treatments, 5-year survival rates for patients have remained low in the last 20 years. Enhancer of zeste homolog 2 (EZH2), part of polycomb repressive complex 2 (PRC2), is highly expressed in human oral SCC samples and cell lines and has been associated with greater epithelia-to-mesenchymal transition (EMT), invasion and metastasis. Here, we developed a tamoxifen-regulated, transgenic mouse line (KcEZH2) in which EZH2 is selectively knocked out (KO) in some tongue epithelial basal stem cells (SCs) i

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