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Artykuły w czasopismach na temat „Organoruthenium compounds”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 20 lutego 2023

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Sprawdź 22 najlepszych artykułów w czasopismach naukowych na temat „Organoruthenium compounds”.

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1

Trobec, Tomaž, Kristina Sepčić, Monika Cecilija Žužek, Jerneja Kladnik, Nina Podjed, Catarina Cardoso Páscoa, Iztok Turel, and Robert Frangež. "Fine Tuning of Cholinesterase and Glutathione-S-Transferase Activities by Organoruthenium(II) Complexes." Biomedicines 9, no. 9 (September 16, 2021): 1243. http://dx.doi.org/10.3390/biomedicines9091243.

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Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on inhibition of ChEs, and on another pharmacologically important group of enzymes, glutathione S-transferases (GSTs). Two groups of organoruthenium(II) compounds were considered: (i) organoruthenium(II) complexes with p-cymene as an arene ligand, and (ii) organoruthenium(II) carbonyl complexes as CO-

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2

Chow, Mun Juinn, Cynthia Licona, Giorgia Pastorin, Georg Mellitzer, Wee Han Ang, and Christian Gaiddon. "Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance." Chemical Science 7, no. 7 (2016): 4117–24. http://dx.doi.org/10.1039/c6sc00268d.

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Varying the arene ligand on organoruthenium compounds induced the differential activation of ER stress pathways, leading to non-apoptotic programmed cell death and bypassing drug resistance mechanisms.

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Shakil, Md Salman, Shahida Parveen, Zohaib Rana, Fearghal Walsh, Sanam Movassaghi, Tilo Söhnel, Mayur Azam, et al. "High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes." Biomedicines 9, no. 2 (January 27, 2021): 123. http://dx.doi.org/10.3390/biomedicines9020123.

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Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a–1c and 3-hydroxy-4-thiopyridones 1d–1f as well as their Ru(η6-p-cymene)Cl complexes 2a–2f, and report here the molecular structures of 1b and 1d as determined by X-ray diffraction analysis. Detailed cell biological investigations revealed potent cytotoxic activity, in particular of the 3-hydroxy-4-thiopyridones 1d–1f, while the Ru complexes of both compound types were less potent, despite still showing antiproliferativ

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4

Mondal, Ashaparna, and Priyankar Paira. "Synthesis and Biological Evaluations of Organoruthenium Scaffolds: A Comprehensive Update." Current Organic Synthesis 15, no. 2 (April 24, 2018): 179–207. http://dx.doi.org/10.2174/1570179414666170703143049.

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Background: Currently ruthenium complexes are immerging as effective anticancer agents due to their less toxicity, better antiproliferative and antimetastatic activity, better stability in cellular environment and most importantly variable oxidation and co-ordination states of ruthenium allows binding this molecule with a variety of ligands. So in past few years researchers have shifted their interest towards organoruthenium complexes having good fluorescent profile that may be applicable for cancer theranostics. Nowadays, photodynamic therapy has become more acceptable because of its easy and

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5

Nogueira, Luciano J., Maria A. de Resende, Sheila R. Oliveira, Maria Helena de Araújo, Thais F. F. Magalhães, Milena B. de Oliveira, Cleide V. B. Martins, Miriam T. P. Lopes, Ana C. Araújo e Silva, and Claudio L. Donnici. "In vitro susceptibility of Aspergillus spp. to dithiocarbamate organoruthenium compounds." Mycoses 54, no. 5 (June 14, 2010): e323-e329. http://dx.doi.org/10.1111/j.1439-0507.2010.01914.x.

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6

Parveen, Shahida, Kelvin K. H. Tong, Muhammad Khawar Rauf, Mario Kubanik, Muhammad Ashraf Shaheen, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, and Christian G. Hartinger. "Coordination Chemistry of Organoruthenium Compounds with Benzoylthiourea Ligands and their Biological Properties." Chemistry – An Asian Journal 14, no. 8 (February 14, 2019): 1262–70. http://dx.doi.org/10.1002/asia.201801798.

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7

Nagy, Eszter Marta, and Dolores Fregona. "Critical comment on: ‘In vitro susceptibility of Aspergillus spp. to dithiocarbamate organoruthenium compounds’." Mycoses 55, no. 1 (August 8, 2011): 101. http://dx.doi.org/10.1111/j.1439-0507.2011.02085.x.

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Gomathi, Asaithambi, Paranthaman Vijayan, Periasamy Viswanathamurthi, Shanmugam Suresh, Raju Nandhakumar, and Takeshi Hashimoto. "Organoruthenium(II) compounds with pyridyl benzoxazole/benzthiazole moiety: studies on DNA/protein binding and enzyme mimetic activities." Journal of Coordination Chemistry 70, no. 10 (March 30, 2017): 1645–66. http://dx.doi.org/10.1080/00958972.2017.1309649.

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Cuccioloni, Massimiliano, Valentina Cecarini, Laura Bonfili, Riccardo Pettinari, Alessia Tombesi, Noemi Pagliaricci, Laura Petetta, Mauro Angeletti та Anna Maria Eleuteri. "Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization". International Journal of Molecular Sciences 23, № 15 (5 серпня 2022): 8710. http://dx.doi.org/10.3390/ijms23158710.

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Alzheimer’s disease (AD) is a fatal neurodegenerative disorder associated with severe dementia, progressive cognitive decline, and irreversible memory loss. Although its etiopathogenesis is still unclear, the aggregation of amyloid-β (Aβ) peptides into supramolecular structures and their accumulation in the central nervous system play a critical role in the onset and progression of the disease. On such a premise, the inhibition of the early stages of Aβ aggregation is a potential prevention strategy for the treatment of AD. Since several natural occurring compounds, as well as metal-based mole

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10

Movassaghi, Sanam, Euphemia Leung, Muhammad Hanif, Betty Y. T. Lee, Hannah U. Holtkamp, Jason K. Y. Tu, Tilo Söhnel, Stephen M. F. Jamieson, and Christian G. Hartinger. "A Bioactive l-Phenylalanine-Derived Arene in Multitargeted Organoruthenium Compounds: Impact on the Antiproliferative Activity and Mode of Action." Inorganic Chemistry 57, no. 14 (June 27, 2018): 8521–29. http://dx.doi.org/10.1021/acs.inorgchem.8b01187.

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11

Hiraki, Katsuma, Naoyuki Ochi, Yoko Sasada, Hideki Hayashida, Yoshio Fuchita, and Shunichiro Yamanaka. "Organoruthenium(II) complexes formed by insertion reactions of some vinyl compounds and conjugated dienes into a hydrido–ruthenium bond." J. Chem. Soc., Dalton Trans., no. 5 (1985): 873–77. http://dx.doi.org/10.1039/dt9850000873.

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12

Wieteck, Marcel, Mie Højer Larsen née Vilhelmsen, Pascal Nösel, Jürgen Schulmeister, Frank Rominger, Matthias Rudolph, Markus Pernpointner, and A. Stephen K. Hashmi. "Conjugated Vinylgold(I)-Vinylideneruthenium(II) Complexes and Related Organoruthenium Compounds: Stable Analogues of Intermediates Proposed in Dual Gold Catalysis." Advanced Synthesis & Catalysis 358, no. 9 (April 27, 2016): 1449–62. http://dx.doi.org/10.1002/adsc.201600255.

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13

Bryndza, Henry E., Peter J. Domaille, Wilson Tam, Lawrence K. Fong, Rocco A. Paciello, and John E. Bercaw. "Comparison of metal-hydrogen, -oxygen, -nitrogen and -carbon bond strengths and evaluation of functional group additivity principles for organoruthenium and organoplatinum compounds." Polyhedron 7, no. 16-17 (January 1988): 1441–52. http://dx.doi.org/10.1016/s0277-5387(00)81773-8.

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14

Pavlović, Marijana, Stefan Nikolić, Nevenka Gligorijević, Biljana Dojčinović, Sandra Aranđelović, Sanja Grgurić-Šipka, and Siniša Radulović. "New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action." JBIC Journal of Biological Inorganic Chemistry 24, no. 2 (February 14, 2019): 297–310. http://dx.doi.org/10.1007/s00775-019-01647-4.

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15

Bryndza, Henry E., Lawrence K. Fong, Rocco A. Paciello, Wilson Tam, and John E. Bercaw. "Relative metal-hydrogen, -oxygen, -nitrogen, and -carbon bond strengths for organoruthenium and organoplatinum compounds; equilibrium studies of Cp*(PMe3)2RuX and (DPPE)MePtX systems." Journal of the American Chemical Society 109, no. 5 (March 1987): 1444–56. http://dx.doi.org/10.1021/ja00239a026.

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16

Marques, F., L. Corte-Real, A. P. Alves de Matos, I. Alho, T. S. Morais, A. I. Tomaz, M. H. Garcia, and M. P. Bicho. "Intracellular distribution of antitumor Ru (II) compounds: The lysosome and the lysosomal enzymes as targets for anticancer metal-based drugs." Microscopy and Microanalysis 19, S4 (August 2013): 9–10. http://dx.doi.org/10.1017/s1431927613000664.

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The therapeutic usefulness of anticancer agents relies on their ability to kill cancer cells while sparing normal cells and tissues. Ruthenium complexes hold great potential as suitable alternative drugs to the current cisplatin in the treatment of cancer. Our approach in this field has been the study of organoruthenium complexes, [RuII(η5-Cp)] family, namely [RuII(η5-Cp)(bipy)(PPh3)]+ (PPh3 = triphenylphosphine; bipy = 2,2’-bipyridine), TM34. This compound was tested for antitumor activity against tumor cells representative of human cancer diseases. A large spectrum of activity was found, lar

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17

Kljun, Jakob, Renata Pavlič, Eva Hafner, Tanja Lipec, Sara Moreno-Da Silva, Primož Tič, Iztok Turel, Tomaž Büdefeld, Jure Stojan, and Tea Lanišnik Rižner. "Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line." Frontiers in Pharmacology 13 (August 11, 2022). http://dx.doi.org/10.3389/fphar.2022.920379.

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In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1–6) and hydroxyquinolinate (7–10) chelating ligands with the general formula [(η6-p-cymene)Ru(chel)(X)]n+ where chel represents the chelating ligand and X the chlorido or pta ligand. Our studies show that these compounds are potent inhibitors of the AKR enzymes with an uncommon inhibitory mechanism, where two inhibitor molecules bind to the enzyme in a fir

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18

Riisom, Mie, Liam Eade, William D. J. Tremlett, and Christian G. Hartinger. "The aqueous stability and interactions of organoruthenium compounds with serum proteins, cell culture medium and human serum." Metallomics, June 25, 2022. http://dx.doi.org/10.1093/mtomcs/mfac043.

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Abstract Metal complexes bind to a wide variety of biomolecules and the control of the reactivity is essential when designing anticancer metallodrugs with a specific mode of action in mind. In this study, we used the highly cytotoxic compound [RuII(cym)(8-HQ)Cl] (cym = η6-p-cymene, 8-HQ = 8-hydroxyquinoline), the more inert derivative [RuII(cym)(8-HQ)(PTA)](SO3CF3) (PTA = 1,3,5-triaza-7-phosphaadamantane), and [RuII(cym)(PCA)Cl]Cl (PCA = pyridinecarbothioamide) as a derivative with a different coordination environment about the Ru center and investigated their stability, interactions with prot

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19

HIRAKI, K., N. OCHI, Y. SASADA, H. HAYASHIDA, Y. FUCHITA, and S. YAMANAKA. "ChemInform Abstract: ORGANORUTHENIUM(II) COMPLEXES FORMED BY INSERTION REACTIONS OF SOME VINYL COMPOUNDS AND CONJUGATED DIENES INTO A HYDRIDO-RUTHENIUM BOND." Chemischer Informationsdienst 16, no. 37 (September 17, 1985). http://dx.doi.org/10.1002/chin.198537275.

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BRYNDZA, H. E., P. J. DOMAILLE, W. TAM, L. K. FONG, R. A. PACIELLO, and J. E. BERCAW. "ChemInform Abstract: Comparison of Metal-Hydrogen, -Oxygen, -Nitrogen and -Carbon Bond Strengths and Evaluation of Functional Group Additivity Principles for Organoruthenium and Organoplatinum Compounds." ChemInform 20, no. 4 (January 24, 1989). http://dx.doi.org/10.1002/chin.198904098.

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BRYNDZA, H. E., L. K. FONG, R. A. PACIELLO, W. TAM, and J. E. BERCAW. "ChemInform Abstract: Relative Metal-Hydrogen, -Oxygen, -Nitrogen, and -Carbon Bond Strengths for Organoruthenium and Organoplatinum Compounds; Equilibrium Studies of Cp*(PMe3)2RuX and (DPPE)MePtX Systems." ChemInform 18, no. 28 (July 14, 1987). http://dx.doi.org/10.1002/chin.198728091.

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Meier-Menches, Samuel M., Benjamin Neuditschko, Lukas Janker, Marlene C. Gerner, Klaus G. Schmetterer, Albrecht Reichle, and Christopher Gerner. "A Proteomic Platform Enables to Test for AML Normalization In Vitro." Frontiers in Chemistry 10 (February 1, 2022). http://dx.doi.org/10.3389/fchem.2022.826346.

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Acute promyelocytic leukaemia (APL) can be cured by the co-administration of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). These small molecules relieve the differentiation blockade of the transformed promyelocytes and trigger their maturation into functional neutrophils, which are physiologically primed for apoptosis. This normalization therapy represents a compelling alternative to cytotoxic anticancer chemotherapy, but lacks an in vitro model system for testing the efficiency of novel combination treatments consisting of inducers of differentiation and metallopharmaceuticals. H

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