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Rozprawy doktorskie na temat „Oro Twp”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 8 lutego 2022

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1

Knape, Camilla, i Maria Gottfridsson. "”En ständig oro” Föräldrars upplevelser när deras barn fått diabetes typ 1". Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20883.

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Diabetes typ 1 är en sjukdom som oftast drabbar barn i tonåren, men kan även drabba yngre. Den upptar mycket tid på grund av blodglukoskontrollerna för att undvika komplikationer. Balanserad kost, samt daglig motion är en del av behandlingen. Barnen kan ta ansvar över egenvården, men behöver stöd från föräldrarna. För att hantera sjukdomen krävs planering och för alla inblandade blir livet förändrat. Sjuksköterskan har en betydande roll för familjen genom att ge information och stöttning. För sjuksköterskan är studien av värde då den kan ge en inblick i föräldrars upplevelser. Därigenom kan sjuksköterskan få en bättre förståelse för hur föräldrarna ser på sjukdomen och vad de behöver hjälp med. För föräldrarna är det betydelsefullt att sjuksköterskan har kunskaper om deras situation för att bemöta dem på ett proffisionellt sätt. Syftet med denna litteraturstudie är att belysa föräldrars upplevelser då deras barn får diabetes typ 1. Uppsatsen bygger på sju vetenskapliga artiklar med kvalitativ design. Under analysen av artiklarna framkom följande huvudteman: Från förnekelse till acceptans, En förändrad vardag och Att inte kunna skydda sitt barn. Resultatet diskuterades under rubrikerna: Upplevelser runt diagnosbeskedet och Behov av information och stöd. Resultet visar att det är viktigt att föräldrarna får ett bra bemötande och god information från sjuksköterskan. För att uppleva trygghet i vardagen behöver föräldrarna stöd från vårdspersonalen och närstående och för att öka föräldrarnas välbefinnande är det viktigt att sjuksköterskan hjälper dem att bygga upp självförtroendet i rollen som vårdare för sitt barn.
Program: Sjuksköterskeutbildning
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2

Birkebo, Julia, i Tove Larsson. "Erfarenheter av att vara förälder till ett barn med diabetes typ-1 : en litteraturstudie". Thesis, Ersta Sköndal Bräcke högskola, Institutionen för vårdvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-8863.

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Bakgrund: Diabetes mellitus typ 1 är en av de vanligaste kroniska sjukdomarna hos barn och forskning har visat på att diabetes typ 1 drabbar allt fler unga människor. Sjukdomen vänder upp och ner på familjens vardag och innebär att föräldern bevakar barnets blodglukosvärde under dygnets alla timmar. För att undvika komplikationer är det viktigt att föräldern stöttar barnet till en balans mellan kost, aktivitet och insulinbehandling.  Föräldrarna ansvarar för barnets egenvård och framtida hälsotillstånd. Syfte: Att beskriva erfarenheter av att vara förälder till barn med diabetes typ 1. Metod:En litteraturöversikt baserad på tolv vetenskapliga studier med kvalitativ design. Sökningarna utfördes i databaserna CINAHL Complete och PubMed. Studierna analyserades inspirerade av Friberg. Resultat:Resultatet redovisas i tre teman: Att ha ansvar för sitt barns sjukdom, Att leva med ständig oro och Att förlora ett normalt liv. Diskussion:Resultatet diskuterades utifrån Dorothea Orems egenvårdsteori. Att ha ett barn med diabetes mellitus typ 1 innebär att ansvara för barnets egenvård, dygnet runt samt att ta ansvaret för sjukdomen och uppleva oron för eventuella komplikationerna, påverkade förälderns fysiska och psykiska mående. Sjuksköterskan har en viktig roll att fånga upp förälderns mående och på så sätt förebygga att det påverkar behandlingen av sjukdomen. Slutsats:Resultatet har visat betydelsen av en helhetsvård och där varje individs situation beaktas.
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3

Jonasson, Josefin, i Elin Nykvist. "Ihållande oro och behov av stöd : Upplevelse av att vara förälder till ett barn med diabetes typ 1". Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-16545.

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Diabetes typ 1 är idag ett växande problem bland barn och ungdomar i Sverige. Den kroniska sjukdomen innebär ett stort egenvårdsansvar. Hälso- och sjukvården har till uppgift att stödja egenvården genom att informera om hur de berörda kan förhindra allvarliga följder som kan uppkomma samt stötta de berörda till en bra livsstil som gynnar sjukdomen. Som sjuksköterska kan man möta de här barnen med diabetes typ 1 och deras föräldrar på vårdcentraler och sjukhus. Det är viktigt att sjuksköterskan är medveten om de känslor och den kunskap föräldrar innehar för att kunna stötta dem på bästa sätt. Syftet med uppsatsen är därför att beskriva föräldrars upplevelser av att leva med ett barn som har diabetes typ 1. Metoden vi valt att använda oss av är en litteraturstudie med grund i 8 kvalitativa artiklar som behandlar föräldrars upplevelser av att leva med ett barn med diabetes typ 1 i vardagen. Vi identifierade tre teman och nio underteman. Vårt resultat visar på en ständig oro hos föräldrarna. Tankarna på det drabbade barnet och sjukdomen finns ständigt i deras medvetande. Redan under barnets unga år infinner sig en oro hos föräldrarna inför tonårsperioden då barnet ska ges ett ökat egenvårdsansvar. Denna oro yttrar sig sedan i ett kontrollbehov vilket påverkar relationen mellan föräldrar och barn. Oron grundar sig i föräldrars upplevelse av kontrollförlust. Föräldrarna upplever även en brist på stöd ifrån hälso- och sjukvården. Diskussionen behandlar behovet av ett ökat stöd till både föräldrar och barn för att underlätta deras vardag. Även idén om en enskild kontaktperson till tonåringar lyfts fram. Vidare behandlas även hur uppmuntran och stöd från föräldrar kan förbättra och stärka förmågan till egenvård hos tonåringar samt behovet av upplyst skolpersonal för att tillgodose de drabbade barnens rättigheter.
Program: Sjuksköterskeutbildning
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4

Nygren, Ellen, i Sandra Schöldqvist. "Att leva med Diabetes Mellitus typ 2 : En litteraturöversikt". Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för omvårdnad, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-35919.

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Background: Diabetes type 2 is a increasing disease and societal problem. To be able to sustain a healthy life despite the disease, major lifestyle changes including dietary changes and physical activity is required. Aim: The aim of this literature review was to describe the experiences of persons living with diabetes mellitus type 2. Method: An inductive approach were used, qualitative articles were analysed by Fribergs Analysis model. Result: Three main themes was discovered; “Psychological effect of diabetes”, “Practical influence on the everyday life with diabetes” and “Social and existential influences of diabetes”. There were six sub-themes found. Conclusion: There were worries about the disease and complications. Motivation was an important factor for necessary self-care. Limitations in daily life was often related to diet and social engagements. High demands of managing lifestyle changes felt arduous. Nurses have an important role in encourage to self-management and should contribute to further individualization in diabetes care.The support was often found inadequate.
Bakgrund: Diabetes mellitus typ 2 är en växande folksjukdom och samhällsproblem. För att bibehålla ett hälsosamt liv trots sjukdomen behöver personerna ofta genomgå livsstilsförändringar i form av ändrade kost- och motionsvanor. Syfte: Syftet med denna litteraturöversikt var att beskriva personers upplevelser av att leva med diabetes mellitus typ 2. Metod: En induktiv ansats användes, kvalitativa artiklar granskades och analyserades genom Fribergs analysmodell. Resultat: Här återfanns 3 huvudteman; “ Psykisk påverkan vid diabetes”, “Praktisk påverkan i vardagen med diabetes” samt “Social och existentiell påverkan vid diabetes”. Det urskildes också sex stycken subteman. Slutsats: Det fanns en ständig oro över sjukdomen och eventuella komplikationer. Motivation och stöd var viktigt för nödvändig egenvård. Begränsningar i det dagliga livet var ofta relaterat till kost och sociala tillställningar. Krav på livsstilsförändringar upplevdes som svåra. Sjuksköterskan har en viktig roll för att uppmuntra till personernas egenvård och borde verka för att ytterligare individanpassa diabetesvården.
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5

Paiba, Giles Abraham. "Epidemiological investigations into two zoonotic diseases : Q fever and orf". Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297825.

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6

Castelli, Joël. "Radiothérapie adaptative morphologique et métabolique des cancers ORL". Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B043/document.

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Objectifs : Notre travail avait pour objectifs (i) d’évaluer le bénéfice dosimétrique et de prédire le bénéfice clinique d’une radiothérapie adaptative pour des cancers des voies aéro‐digestives supérieures, à la fois en termes de toxicité et de contrôle local, (ii) d’identifier les patients bons candidats à une stratégie de radiothérapie adaptative, et (iii) d’identifier le meilleur schéma de radiothérapie adaptative pour épargner les parotides. Matériels et méthodes : Le bénéfice dosimétrique a été évalué en utilisant les données de patients inclus dans une étude de phase III évaluant le bénéfice clinique d’une radiothérapie adaptative. La dose cumulée sans et avec radiothérapie adaptative a été estimée par des méthodes de recalage élastique. Une évaluation des différents algorithmes de recalage a été faite à la fois en termes de précision spatiale et d’impact sur la dose estimée. Des modèles de prédiction du risque de surdosage ont été développés en utilisant des modèles linéaires généralisées mixtes et une validation croisée par leave‐one‐out. L’évaluation de différents schémas de radiothérapie adaptative (en termes de fréquence et de nombre) a été réalisée en se basant sur l’épargne des parotides. La valeur prédictive de paramètres quantitatifs issus de la TEP a été évaluée à travers une revue systématique de la littérature. La valeur prédictive de paramètres intensité issue de la TEP a été analysée dans 2 cohortes indépendantes. Résultats : Nos travaux ont confirmé qu’en l’absence de radiothérapie adaptative pour des cancers des VADS, il existe un risque de surdosage des parotides de plus de 2 Gy pour les 2/3 des patients. Il s’y associe un risque de sous dosage de la tumeur de plus de 1 Gy pour 50 % des patients. Une radiothérapie adaptative permet de corriger à la fois le surdosage des parotides (bénéfice clinique estimée de 10 % de diminution du risque de xérostomie) et le sous dosage de la tumeur. Basés sur des paramètres issus de la planification et de la première semaine de traitement, des modèles de prédiction du risque de sur dosage des parotides ou de sous dosage de la tumeur ont été développés. Les paramètres TEP prédictifs du risque de récidive ont été identifiés. Un nomogramme a pu être développé et validé dans une 2nd cohorte de patients. Conclusion : Nos travaux confirment le bénéfice d’une radiothérapie adaptative pour épargner les parotides et maintenir la couverture tumorale. Ce bénéfice dosimétrique devrait permettre une diminution de la toxicité et une amélioration du contrôle local. Des paramètres anatomiques et dosimétriques simples permettent l’identification des patients à risque de surdosage des parotides ou de sous dosage de la tumeur. L’utilisation de la TEP permet d’identifier précocement les patients à haut risque de récidive, candidats potentiels à une intensification thérapeutique. Ces résultats justifient la poursuite des travaux sur une cohorte de patients plus importante, idéalement dans le cadre d’études cliniques de phase III
Objectifs: The aims of this work were (i) to evaluate the dosimetric benefit and to predict the clinical benefit of adaptive radiotherapy for head and neck cancer, regarding both toxicities and local control, (ii) to identify patients whose good candidate for an adaptive strategy, and (iii) to identify the best adaptive strategy to spare the parotid glands. Materials and methods: The dosimetric benefit was assessed using data from a phase III study evaluating the clinical benefit of an adaptive radiotherapy. Cumulated dose with and without adaptive was estimated using deformable image registration. Different methods of deformable image registration were evaluated regarding both spatial and dose estimation accuracy. Predictive model of the risk of parotid gland overdose was computed using generalized linear mixed model and cross validation by leave‐one‐out. The dosimetric benefit of numerous replanning strategies, defined by various numbers and timing of replanning, with regard to parotid gland sparing, was quantified. We performed a systematic review to evaluate the predictive value of quantitative PET parameters. The predictive value of PET intensity parameters was assessed using two independent cohorts of patients. Résultats: Without adaptive radiotherapy, 65% of the patients had a PG overdose of more than 2 Gy and 50% of the patients had a tumor underdose of more than 1 Gy. Adaptive radiotherapy allows to correct both parotid gland overdose and tumor underdose. Based on parameters calculated at the planning and at the first week of treatment, predictive models of PG overdose and tumor underdose were computed. PET parameters correlated with overall survival were identified. Using two independent cohorts of patients, a nomogram to predict survival was build and externally validated. Conclusion: Our studies showed the benefit of adaptive radiotherapy to spare the parotid glands while increasing tumor coverage. These benefits should allow to decrease the toxicities while increasing local control. Early anatomical and dosimetric parameters allow identifying patients at risk of tumor underdose or parotid gland overdose. PET performed before the treatment allows identifying patients with a high‐risk of locoregional failure and death, potentially candidates for treatment. These results justify further studies on a larger cohort of patients, ideally in phase III clinical trials
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7

Markezich, Allan Louis Riddle Wayne A. "Late season physiological adaptations of two syntopic araneid spiders". Normal, Ill. Illinois State University, 1987. http://wwwlib.umi.com/cr/ilstu/fullcit?p8726505.

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Thesis (Ph. D.)--Illinois State University, 1987.
Title from title page screen, viewed August 16, 2005. Dissertation Committee: Wayne A. Riddle (chair), D. Reed Jensen, Steven A. Juliano, Charles F. Thompson, James N. Tone. Includes bibliographical references (leaves 103-118) and abstract. Also available in print.
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8

Bluhm, Martina E. C., Viktoria A. F. Schneider, Ingo Schäfer, Stefania Piantavigna, Tina Goldbach, Daniel Knappe, Peter Seibel, Lisandra L. Martin, Edwin J. A. Veldhuizen i Ralf Hoffmann. "N-Terminal Ile-Orn- and Trp-Orn-Motif repeats enhance membrane interaction and increase the antimicrobial activity of Apidaecins against Pseudomonas aeruginosa". Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205372.

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The Gram-negative bacterium Pseudomonas aeruginosa is a life-threatening nosocomial pathogen due to its generally low susceptibility toward antibiotics. Furthermore, many strains have acquired resistance mechanisms requiring new antimicrobials with novel mechanisms to enhance treatment options. Proline-rich antimicrobial peptides, such as the apidaecin analog Api137, are highly efficient against various Enterobacteriaceae infections in mice, but less active against P. aeruginosa in vitro. Here, we extended our recent work by optimizing lead peptides Api755 (gu-OIORPVYOPRPRPPHPRL-OH; gu = N,N,N′,N′-tetramethylguanidino, O = L-ornithine) and Api760 (gu-OWORPVYOPRPRPPHPRL-OH) by incorporation of Ile-Orn- and Trp-Orn-motifs, respectively. Api795 (gu-O(IO)2RPVYOPRPRPPHPRL-OH) and Api794 (gu-O(WO)3RPVYOPRPRPPHPRL-OH) were highly active against P. aeruginosa with minimal inhibitory concentrations of 8–16 and 8–32 μg/mL against Escherichia coli and Klebsiella pneumoniae. Assessed using a quartz crystal microbalance, these peptides inserted into a membrane layer and the surface activity increased gradually from Api137, over Api795, to Api794. This mode of action was confirmed by transmission electron microscopy indicating some membrane damage only at the high peptide concentrations. Api794 and Api795 were highly stable against serum proteases (half-life times >5 h) and non-hemolytic to human erythrocytes at peptide concentrations of 0.6 g/L. At this concentration, Api795 reduced the cell viability of HeLa cells only slightly, whereas the IC50 of Api794 was 0.23 ± 0.09 g/L. Confocal fluorescence microscopy revealed no colocalization of 5(6)-carboxyfluorescein-labeled Api794 or Api795 with the mitochondria, excluding interactions with the mitochondrial membrane. Interestingly, Api795 was localized in endosomes, whereas Api794 was present in endosomes and the cytosol. This was verified using flow cytometry showing a 50% higher uptake of Api794 in HeLa cells compared with Api795. The uptake was reduced for both peptides by 50 and 80%, respectively, after inhibiting endocytotic uptake with dynasore. In summary, Api794 and Api795 were highly active against P. aeruginosa in vitro. Both peptides passed across the bacterial membrane efficiently, most likely then disturbing the ribosome assembly, and resulting in further intracellular damage. Api795 with its IOIO-motif, which was particularly active and only slightly toxic in vitro, appears to represent a promising third generation lead compound for the development of novel antibiotics against P. aeruginosa.
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9

Persson, Johan. "Taluppfattning av enstaviga ord i stationärt brus med och utan top-down stöd". Thesis, Linköpings universitet, Institutionen för datavetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80760.

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Teorier inom Kognitiv hörselvetenskap beskriver hur uppfattning av tal beror på två olika typer av processer. Bottom-up processer associeras med akustiska och fonetiska egenskaper hos en inkommande signal och top-down processer associeras med lexikala, syntaktiska, semantiska samt kontextuella egenskaper. Förmågan att utnyttja top-down processer tros bero på kapaciteten hos arbetsminnet. För att undersöka en skillnad mellan bottom-up och top-down samt deras förhållande till arbetsminnet har ett Speech-in-Noise (SIN) test utformats och genomförts på 15 försöksdeltagare. Testet undersöker skillnader i tröskelvärden för att identifiera ett enstavigt ord i ett uppåtgående förhållande till stationärt brus, mot tröskelvärden för att identifiera ett enstavigt ord i stationärt brus med hjälp att top-down stöd. Top-down stöd ges i form av explicit priming och undersöks i både uppåtgående och nedåtgående förhållande till bruset. Två typer av arbetsminnestest, ”Letter Memory Test” och ”Reading Span Test”, användes för att undersöka en korrelation med differenser mellan tröskelvärdena. Resultaten visade på en signifikant skillnad mellan vanliga tröskelvärden och tröskelvärden då explicit top-down stöd används. Någon signifikant korrelation mellan kapaciteten hos arbetsminnet och differenserna dessa tröskelvärden fanns inte.  Dock så fann analysen en signifikant korrelation mellan skillnad i tröskelvärden, för top-down stöd i uppåtgående och nedåtgående förhållande till brus, och ”Letter Memory Test”.
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10

Krantz, Irina. "Upplevda hinder och risker vid fysisk aktivitet hos typ 1 diabetiker : En systematisk litteraturstudie". Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17399.

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Introduction: In Sweden, 450,000 people suffer from diabetes, of which 10-15% have type 1 diabetes. Individuals who have lived with the disease for a long time run the risk of complications. Physical activity is central to the treatment, but there are risks and obstacles that can lead to the individual avoiding physical activity.  Aim: The purpose is to investigate perceived risks and other obstacles during physical activity for type 1 diabetics.  Methods: The choice of method was a systematic literature study. The databases WorldCat Discovery and Pubmed were used in the search of reports. After the search, 10 reports were selected, and a thematic analysis was applied. Then 3 themes were chosen which were later used to analyze the reports. They were as follows: the fear and the risk of hypoglycemia, the obstacles and remedies in relation to physical activity and behavioral changes in the individual.  Results: The fear of a hypoglycemia prevents the individual from exercising. The result showed that women suffers from anxiety concerning their diabetes to a greater extent than men. Aids such as Continuous Glucose Monitoring can minimize anxiety and the risk of getting into hypoglycemia during physical activity.  Conclusion: Constantly worrying about getting into hypoglycemia can cause the individual to stop caring for the risks associated with the disease. One of the factors that led to the individual being unable to perform physical activity was hyperglycaemia. Continuous blood glucose monitoring as well as support of personnel at exercise facilities can lead to the individual overcoming obstacles and concerns.
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Vergez, Sébastien. "Prédiction de la réponse à l'erlotinib dans les cancers épidermoïdes ORL". Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1065/.

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En cancérologie ORL, en l'absence de facteur prédictif de réponse, il est indispensable de pouvoir identifier les patients susceptibles de répondre à un traitement par inhibiteurs des récepteurs de facteurs de croissance des épidermes (EGFR). Nous avons validé l'usage de la Tomographie par Emission de Positons au 18Fluoro-D-glucose (TEP-FDG) pour évaluer précocement les effets de l'erlotinib. Lors d'études préclinique et clinique, nous avons démontré qu'erlotinib inhibait la phosphorylation d'ERK-1/2, sans diminuer l'expression de Glut-1. L'inhibition de Phospho-ERK-1/2 a été significativement corrélée à une diminution de fixation tumorale en TEP-FDG en préclinique et en clinique. Nous avons donc démontré que la TEP-FDG permettait d'effectuer une évaluation précoce de la réponse à l'erlotinib. Nous avons étudié le rôle d'eIF4E (marqueur de résistance aux inhibiteurs de l'EGFR et HER2 dans les cancers coliques et mammaires) dans la réponse aux inhibiteurs de l'EGFR en ORL. Dans les lignées cellulaires CAL33 présentant une résistance acquise, erlotinib n'inhibe pas l'initiation de la traduction protéique (en diminuant l'intégration d'eIF4E au complexe eIF4F comme cela est constaté avec des lignées CAL33 parentales). Chez des patients traités par erlotinib, une diminution significative d'expression d'eIF4E a été observée dans le groupe des répondeurs (n=11) comparé aux non-répondeurs (n=26). En association avec radiothérapie ou un sel de platine, les patients non-répondeurs au cetuximab présentaient significativement un plus haut niveau d'expression d'eIF4E en pré-thérapeutique (n=8). L'expression d'eIF4E joue un rôle clé dans la réponse aux inhibiteurs de l'EGFR dans les cancers épidermoïdes ORL
There is a clinical need to identify predictive markers of the response to epidermal growth factor receptor (EGFR) inhibitors in patients with head and neck squamous cell carcinoma (HNSCC). We validated the Positron Emission Tomography of 18Fluoro-D-glucose (18FDG-PET/CT) for monitoring the early effects of erlotinib on tumor activity. Erlotinib strongly inhibited ERK-1/2 phosphorylation in both preclinical models (HNSCC) and in patients. Western blotting, immunofluorescence and immunohistochemistry showed that erlotinib did not modify Glut-1 in cell line models or in tumor tissue from mouse xenografts or in patients. Phospho-ERK-1/2 inhibition was significantly associated with a reduction in 18FDG uptake in animal and human tumors. We then demonstrated that the 18FDG-PET/CT response was a reliable surrogate marker of the effects of erlotinib in HNSCC. We investigated the marker eIF4E (a potentially resistance marker to HER inhibitors in colorectal and breast cancers) in the response to EGFR inhibitors in HNSCC. In the CAL33 cell lines presenting an acquired resistance, erlotinib did not inhibit the translation initiation by decreasing the eIF4E integration to the eIF4F complex (as seen with wild-type cell lines). With patients under erlotinib, a significant decrease of eIF4E expression was seen in the responders' group (n=11) compared to non-responders (n=26). In combination with radiotherapy or cisplatin, patients non-responders under cetuximab presented in initial biopsies examination significant higher level of eIF4E (n=8). EIF4E expression level appeared to be determinant to discriminate the response to the EGFR inhibitors erlotinib and cetuximab in HNSCC
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De, Beer Francis. "The characterisation of a two stage flotation circuit treating a complex platinum and chromite ore". Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/16119.

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Bibliography: pages [144]-152.
The methodology was developed to characterise the complex MF2 circuit at Impala Platinum Ltd. The circuit was divided into individual units and each unit was evaluated over a period of time. The performance of each unit in terms of platinum, palladium, rhodium and chromite recoveries was determined by sampling around the unit. The changes in ore floatability characteristics were monitored by carrying out batch flotation tests on samples taken from the feed to each unit. The mixing in the units was characterised by performing residence time distribution studies on the units. The batch flotation results were modelled using a distributed rate approach. The model yielded parameters which were associated with three floatability classes, viz. a fast floating, a medium floating and, a slow floating class and a class for valuable minerals which did not float. The model was not able to discriminate between mineralogical and particle size effects on flotation rates. This would be an important prospect of a future investigation. The rate constants associated with each floatability fraction obtained from the batch flotation together with residence time distribution results were used in association with the actual recoveries from each unit. These factors were used to simulate the performance of the circuit. The same model was used for all the units and the differences in cell design as indicated by hydrodynamics, aeration rate, etc. were accounted for in the· mixing parameters and flotation rates. This procedure to simulate plant performance was successfully applied to three different circuits thus confirming its validity. The difference in the three simulated circuits was in the cleaning stages. Among other things, the simulation shows that the best ·platinum, palladium and rhodium recoveries could be obtained if the greatest cleaning capacity was situated in the secondary stage of the circuit. Although the changes in the circuit configuration could be simulated to establish the effect on the platinum, palladium and rhodium recoveries, the chromite recovery could not be simulated. This is due to the fact that chromite is mainly floated by entrainment which is not incorporated into the model. Since the chromite recovery is crucial for the design of optimum cleaning circuits in the flotation of UG-2 ore, research needs to be done to quantify the entrainment phenomenon.
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Jönsson, Marie. "Vilka coping-strategier använder sig föräldrar av för att klara av den omställning som följer av att ha ett barn med typ 1 diabetes? : en kvalitativ studie". Thesis, Högskolan Väst, Avdelningen för psykologi, pedagogik och sociologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-15805.

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Tidigare forskning visar att vara förälder till ett barn med typ 1-diabetes är krävande på många olika sätt. Många föräldrar till barn med typ 1-diabetes blir utbrända på grund av den stress och oro som följer. Hur klarar en förälder det egentligen? Forskning kring föräldrars oro och stress är omfattande, men studier som fokuserar på föräldraskapet ur ett mer positivt perspektiv är mer sällsynta. Avsikten med denna undersökning var att få en inblick i vad som krävs av föräldrar till barn med typ 1-diabetes. Hur gör de för att inte bli utbrända? Hur gör de för att hantera all stress och oro? Kan det komma några positiva aspekter av detta? Följande frågeställning formulerades: Vilka coping-strategier använder sig föräldrar av för att klara av den omställning som följer av att ha ett barn med typ 1diabetes? Undersökning genomfördes kvalitativt med 25 semi-strukturerade intervjuer samt upplevelsesampling. Urvalet var 20 mödrar och 5 fäder till barn med typ 1-diabetes. Undersökningens kvalitativa ansats möjliggjorde försöket att förstå och tolka det unika och specifika, likaså upplevelsesampling. Empiridriven tematisering tillämpades. Det viktigaste resultatet som framkom ur analysen var föräldrarnas syn på sjukdomen. En viktig coping strategi som framkom var att acceptera, och att försöka på alla sätt få vardagen så normal som möjligt för barnen. För föräldrarna var det viktigt att släppa andra måsten och att vara i nuet hos barnen, samt att inte anklaga sig själva för sämre blodsockerdagar. Att finna en tillit och en ny form av ödmjukhet inför livet. Resultaten i denna studie bekräftar tidigare forskningsresultat kring de negativa aspekterna. Studiens resultat ger förhoppningsvis en ökad förståelse för vad det innebär att vara förälder till ett barn med typ 1 diabetes, och ger ny kunskap från det positiva perspektivet.
Previous research shows that being a parent of a child with type 1 diabetes is challenging in many ways. Many parents of children with type 1 diabetes are burned out due to the stress and anxiety that ensues. How does a parent manage it? Research on parents' anxiety and stress are extensive, but studies that focus on being a parent to a child with type 1 diabetes, from a more positive perspective are more rare. The focus of this study is to see what is required of parents of children with type 1 diabetes. How do they not get burned out? How do they handle all the stress and worry? Can any positive aspects come out of this? The following question is formulated: What coping strategies do parents use to cope with the change that comes from having a child with type 1 diabetes? The survey was conducted qualitative with 25 semi-structured interviews and experience samplings. The sample included 20 mothers and 5 fathers of children with type 1 diabetes. The qualitative approach of the study enabled the attempt to understand and interpret the unique and the specific, and the same with experience sampling. The results were based on empirically driven thematization. The most important result that emerged was the parent's view of the disease. An important coping strategy for the parents was to accept and to try to make everyday life as normal as possible for the children. For the parents, to let go of other things they must do and be present with the children, and to not accuse themselves of bad blood sugar-days. Finding trust and a new humility for life. The results of the study confirm previous research findings on the negative aspects. The results of this study will hopefully give you an increased understanding of what it means to be a parent to a child with type 1 diabetes, and provide new knowledge from the positive perspective.
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Nwolley, Ryna, i Em Eklöv. "Personer med diabetes mellitus typ 2 och upplevelse av psykisk hälsa : En litteraturöversikt". Thesis, Hälsohögskolan, Jönköping University, HHJ, Avd. för omvårdnad, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48915.

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Bakgrund: Diabetes mellitus typ 2 (DMT2) är en globalt växande sjukdom som påverkar personers fysiska, psykiska och sociala välmående. Förändrad livsstil är centralt vid behandlingen och innebär stort ansvar både för personen med DMT2 och sjuksköterskan. Livsstilsförändringar och egenvård kan påverka personers psykiska förmåga och det är av vikt att få djupare kunskap inom detta område. Hälso- och sjukvårdens roll att informera, motivera, och stödja personen är därmed betydelsefull för verksam behandling. Syftet: Var att beskriva personers upplevelse av psykisk hälsa i samband med diabetes mellitus typ 2. Metod: Litteraturöversikt med induktiv ansats, av 11 kvalitativa artiklar som blev resultatet av sökningar i databaserna CINAHL och Medline. Artiklarna analyserades enligt Fribergs fem-stegs-analys. Resultat: Vid analysen framkom tre teman och åtta subteman: att få diagnosen (hanterbart, ignorera, oro för komplikationer, relationer påverkas), omgivningsstöd (möjlighet till inform ation, stödfrån familjen), och daglig anpassning (livsstilsförändringar, upplevelse av egenvård). Slutsats: Personer upplever livsstilsförändringar som utmanande och svår då kunskap brister kring sjukdomen samt i samband med sämre psykiskt mående. Personer med diabetes mellitus typ 2 behöver individanpassad information och stöd från hälso- och sjukvårdpersonal för att kunna hantera dagligt liv.
Background: Diabetes type 2 is a globally growing disease that affect people's physical, mental and social wellbeing. Lifestyle changes is central in treating DMT2 and involves a great deal of responsibility both on the person and the nurse. Lifestyle changes and self-care can increase a person's psychological stress and are important to gain deeper knowledge about. Healthcare professional’s role in informing, motivating and supporting the person is thus important for effective treatment. Aim: Persons experience of mental health with diabetes mellitus type 2. Method: A literature review with an inductive approach, of 11 qualitative articles that were the result of searches in the databases CINAHL and Medline. The articles were analyzed according to Friberg’s five step analysis method. Result: In the analysis three themes and eight subthemes emerged: getting the diagnosis (manageable, ignoring, concerns about complications, relations are affected), surrounding support (opportunity for information, support from the family), and daily adjustment (lifestyle changes, experience of self-care). Conclusion: People experience lifestyle changes as challenging and difficult when there was a lack of knowledge about the disease and with mental health issues. Persons with diabetes mellitus type 2 need individualized information and support from healthcare professionals to be able to have a manageable daily life.
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Andersson, Joel. "Structural evolution of two ore-bearing Palaeoproterozoic metasupracrustal belts in the Kiruna area, Northwestern Fennoscandian Shield". Licentiate thesis, Luleå tekniska universitet, Geovetenskap och miljöteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-72034.

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In this project, two key study areas in the northwestern Fennoscandian Shield are under investigation. The “Western supracrustal belt” and “Central Kiruna area” are both located along lithotectonically comparable Rhyacian-Orosirian metasupracrustal belts and both areas are characterized by iron oxide-apatite (IOA) and iron oxide-copper-gold (IOCG)-style mineralizations and related hydrothermal alterations. The area is in general well studied but the structural evolution remains unresolved. In order to build a structural framework for the Kiruna area, the number of deformation events, kinematics, geometries, mineralogy and interrelationships of the dominant structures are under focus in this study. The paired structural-alteration configuration is targeted in order to constrain the relative timing of dominant structures and mineral alteration parageneses in order to use these systems as structural vectors of mineralized systems. Furthermore, the Orosirian stratigraphy is re-evaluated in order to constrain the pre-compressional geological history of the study areas. This is important as it controls the character of the structural development during subsequent compression forming the sub-surface architecture as we see today. The Orosirian stratigraphy suggests the development of a syn-extensional basin in Kiruna where iron oxide-apatite deposits were emplaced. This basin was subsequently inverted accompanied by shearing, folding, and faulting during D1 and D2, refolded during D3, and further fractured during D4. The shortening directions inferred during the deformation events suggest a clockwise rotation of the stress field from NE-SW (D1) to E-W (D2) and finally NNW-SSE (D3). Regional scapolite ± albite alteration is interpreted to be coeval with regional amphibole + magnetite alteration during D1. Mineral alteration parageneses linked to D2 is more potassic in character and often structurally controlled by shear zones. As a regional generalization, the potassic dominated D2-alteration is characterized by sericite ± epidote ± biotite ± chlorite ± magnetite ± sulphide ± K-feldspar. Fe- and Cu-sulphides are concentrated into brittle D2-structures suggesting that a IOCG-style of mineralization can be linked to the potassic D2 event. This implies that iron oxide-apatite emplacement can be linked to the basin development phase, whereas epigenetic Fe- and Cu-sulphides are linked to the basin inversion-phase of the geological evolution, and hence, separated in time and probably not directly genetically linked in Kiruna.
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Ottino, Gabriele Zannetti Luca Iollo Angelo. "Two approaches to the study of detached flows". S. l. : S. l. : Bordeaux 1 ; Politecnico di Torino, 2009. http://ori-oai.u-bordeaux1.fr/pdf/2009/OTTINO_GABRIELE_2009.pdf.

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Thèse de doctorat : Sciences physique et de l'ingénieur. Mécanique des fluides et mathématiques appliquées : Bordeaux 1 : 2009. Thèse de doctorat : Sciences physique et de l'ingénieur. Mécanique des fluides et mathématiques appliquées : Politecnico di Torino : 2009.
Titre provenant de l'écran-titre.
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Dal, Julien. "The Regionalization of Top Management Teams A study of the TOP 100 Swiss Companies from 2001 to 2007 /". St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/07600893001/$FILE/07600893001.pdf.

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Johnson, Nancy Ann 1958. "Geochemistry of two exhalite horizons at the Copper Chief Mine, Jerome District, Arizona". Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/558106.

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Imbach, Mathias. "Indian multinational corporations' top management teams Composition and impact /". St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/03603453001/$FILE/03603453001.pdf.

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Hegnauer, Jean-Michel. "Firm and top management team internationalization in the energy sector". St. Gallen, 2006. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01709344001/$FILE/01709344001.pdf.

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Gudmundsson, Oskar, i Isabelle Vörén. "Vad påverkar förekomsten av typ II-fel? : En kvantitativ studie om uteblivnafortlevnadsvarningar i revisorersrapportering". Thesis, Umeå universitet, Företagsekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172215.

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Fallet om Prosolvia ledde till det största skadeståndet som någonsin utfärdats i svensk domstol. Orsaken var att revisorn för bolaget inte hade rapporterat om väsentliga osäkerheter och felaktigheter i den finansiella rapporten trots att dessa förelåg. Detta ledde till att Prosolvia senare ansökte om konkurs. När ett bolag går i konkurs inom 12 månader från senaste räkenskapsåret och revisorn inte utfärdar en fortlevnadsvarning gör revisorn ett typ II-fel. Trots risken för skadestånd uppstår typ II-fel frekvent vilket visar på svårigheten och komplexiteten med fortsatt drift-bedömningen för revisorer. Tidigare studier har undersökt vad som kan tänkas påverka uppståndelsen av typ II-fel. Denna studie utökar forskningen genom att undersöka om revisorns kön, klientens bransch och ortens storlek påverkar sannolikheten av att revisorn gör ett typ II-fel samt studerar sambandet mellan finansiell stress och typ II-fel från revisorers perspektiv. Studien har skett med hjälp av ett kvantitativt tillvägagångssätt och analys. Enbart svenska onoterade bolag har använts för undersökningen. De bolag som utgör studiens dataunderlag har vidare haft sin senaste årsredovisning 2018, konkursen har varit inledd inom 12 månader från senaste räkenskapsår och en årsredovisning med revisionsberättelse har funnits tillgänglig. Resultaten indikerar på att vissa branscher påverkar sannolikheten av att revisorn gör ett typ II-fel samt att det finns väsentliga skillnader vad gäller finansiellt stressade bolag i revisorns fortsatt drift-bedömning. För räkenskapsåret 2018 hade 76 procent av bolagen som inlett konkurs inom 12 månader från senaste räkenskapsåret en revisor som gjort ett typ II-fel, vilket tyder på låg revisionskvalité överlag. Detta är något som måste förbättras i hopp om att förhindra och undvika fall, så som Prosolvia, från att upprepas. Studien bidrar till nuvarande forskning genom en holistisk vy av fortsatt drift-problematiken i en svensk kontext för helåret 2018, samt möjliggör för ytterligare forskning inom typ II-fel genom jämförelse med fler år. Studiens resultat ger vidare en ökad insikt kring typ II-fel, vilket kan assistera revisorer och revisionsbyråer i praktiken, men även myn-digheter eller likvärdiga regelsättare att förbättra fortsatt drift-rapporteringen. Det kan på så vis förbättra revisionskvalité vilket i sin tur gynnar samhället och näringslivet.
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Varoquaux, Arthur Damien. "Evaluation clinique et expérimentale des nouvelles modalités d'imagerie dans la prise en charge des néoplasies ORL notamment par la TEP/IRM". Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5058.

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En oncologie ORL, l'imagerie multiparamétrique est utilisée par un nombre grandissant d'équipes. Parmi les bio-marqueurs, la captation normalisée du fluoro-désoxyglucose (SUV-FDG) en tomoscintigraphie par émission de positons (TEP) et la restriction de la diffusion en IRM (DWI-MRI) sont les plus utilisées.L'IRM couplée à la TEP (TEP/IRM) est une nouveauté qui permet une diminution très significative des doses d'irradiation délivrées par rapport à la TEP/TDM. Nous adressons notre première expérience concernant l'aspect en diffusion et en TEP/IRM dans la surveillance des patients après radio-chimiothérapie. A la question de l'interchangeabilité du FDG-PET et de la DWI-MRI, nous avons tenté d'identifier un lien en imagerie entre la cellularité tumorale et sa consommation glucidique. La cellularité tumorale est approchée en IRM par la mesure du coefficient apparent de diffusion (ADC) et son métabolisme glucidique est approché en TEP en utilisant le 18F-desoxyglucose (FDG) par la mesure de la valeur de fixation normalisée (SUV). Dans une série appariée de 33 patients, nous avons analysé la reproductibilité des mesures de l'ADC et de SUV. Puis nous avons évalué l'indépendance statistique de ces biomarqueurs. Nous avons ensuite voulu comparer les résultats de la TEP obtenus à partir de la TEP/TDM et de la TEP/IRM. Dans une série prospective appariée chez 32 patients explorés en FDG-TEP, nous avons évalué qualitativement les images obtenues par la fusion des images recalées en TEP/IRM et TEP/TDM. Nous avons ensuite comparé la pertinence clinique des deux techniques. Et enfin nous avons comparé les valeurs quantitatives de SUV obtenues du tissu sain et du tissu pathologique
Multiparametric imaging interest and clinical use is rising for head and neck carcinoma (HNC). Among these modalities, FDG in PET and DWI-MRI are the most studied. PET/MRI is a new modality that allows in a single examination of combined various biologic biomarkers.After an optimization process of PET/MRI, we applied our first experience concerning the aspects of DWI-MRI and PET-MRI after radiation therapy. Thereafter we studied the correlation of SUV and ADC in HNC. In this study SUV and ADC values were independent parameters in HNSCC. Measurements of these two biomarkers were reproducible with almost perfect observer agreements for both methods. Neither SUV nor ADC values were able to predict the histologic grade, although a trend towards higher SUV and lower ADC values was observed in poorly differentiated tumours. Secondly, we we studied detection and quantification of focal uptake in head and neck tumours: 18F-FDG PET/MRI versus PET/CT in 32 consecutive HNSCC who underwent 18F-FDG PET/MRI and PET/CT. Attenuation correction sequence for PET/MRI and CT for PET/CT were used to caculate SUV. In results, PET/MRI coregistration and image fusion was feasible in all patients. There was no statistically significant difference between PET/MRI and PET/CT regarding rating scores for image quality, fusion quality, lesion conspicuity or anatomic location, number of detected lesions and number of patients with and without malignant lesions. A high correlation was observed for SUV measured on PET/MRI and PET/CT. SUV measured on PET/MRI were significantly lower than on PET/CT for malignant tumours, metastatic neck nodes, benign lesions, bone marrow, and liver (p <0.05)
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Perold, Jacques. "Ceramic parameters in the financial evaluation of brick clay deposits, with reference to two South African examples". Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-08212007-121848.

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Schaub, Matthias. ""One Country, Two Systems" - A Solution for the China-Taiwan Issue?" St. Gallen, 2005. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/99627226001/$FILE/99627226001.pdf.

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Steinmark, Wilhelm. "Leisure and Competencies A Qualitative Study of Top Managers' Leisure Activities /". St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02607885002/$FILE/02607885002.pdf.

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Widman, Börjesson Sara. "Taluppfattning i ofördelaktiga förhållanden : Hur påverkar kognitiv förmåga perceptionen av enstaviga ord i brus bestående av talande röster?" Thesis, Linköpings universitet, Institutionen för datavetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108950.

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Inom disciplinen kognitiv hörselvetenskap tillämpas en integrerad ansats där taluppfattning beskrivs ur både ett auditivt bottom-up-perspektiv och ett kognitivt top-down-perspektiv. Studien undersökte hur taluppfattning varierar med, respektive utan top-down-stöd och vad de kognitiva förmågorna uppmärksamhet, minne och inhiberingsförmåga hade för inverkan. Taluppfattningsförmåga utvärderades med hjälp av ett Speech-In-Noise-test (SIN-test) som bestod av tre deltest där enstaviga ord presenterades i en ofördelaktig miljö bestående av röster som talande i mun på varandra. I deltest 1 presenterades ord i uppåtgående förhållande till rösterna utan kognitivt stöd, i deltest 2 presenterades ord i nedåtgående förhållande till rösterna med kognitivt stöd och i deltest 3 presenterades ord i uppåtgående förhållande till rösterna med kognitivt stöd. Detta resulterade i identifiering av tre tröskelnivåer för taluppfattning. Kognitiva förmågor utvärderades med hjälp av Reading span test, Size Comparison span task (SIC-span) och Paced Auditory Serial-Addition Test (PASAT). Envägs variansanalys av taluppfattningstesten visade på signifikanta skillnader mellan alla tre testen. I test 2 identifierades lägst tröskelvärde, därefter test 3 och slutligen test 1. Korrelationsanalys visade på icke signifikanta samband mellan de tre SIN-testen. Av de kognitiva förmågorna och SIN- testen visade endast PASAT A på ett signifikant samband med SIN-test 2. Analys av de kognitiva förmågorna och differenserna mellan SIN-testen gav inga signifikanta samband. Slutligen vid analys av de kognitiva förmågorna hade PASAT A och PASAT B ett starkt positivt samband medan PASAT B och Reading span test hade ett starkt negativt samband. Resultaten i studien talade för att top-down-stöd ger bättre taluppfattningsförmåga och att uppmärksamhetskapacitet är en förmåga som har en signifikant inverkan på taluppfattning i nedåtgående förhållande till ett brus av röster.
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Weis, Franz. "Oxygen and iron isotope systematics of the Grängesberg Mining District (GMD), Central Sweden". Thesis, Uppsala universitet, Berggrundsgeologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-192216.

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Iron is the most important metal for modern industry and Sweden is the number one iron producer in Europe. The main sources for iron ore in Sweden are the apatite-iron oxide deposits of the "Kiruna-type", named after the iconic Kiruna ore deposit in Northern Sweden. The genesis of this ore type is, however, not fully understood and various schools of thought exist, being broadly divided into "ortho-magmatic" versus the "hydrothermal replacement" approaches. This study focuses on the origin of apatite-iron oxide ore of the Grängesberg Mining District (GMD) in Central Sweden, one of the largest iron reserves in Sweden, employing oxygen and iron isotope analyses on massive, vein and disseminated GMD magnetite, quartz and meta-volcanic host rocks. As a reference, oxygen and iron isotopes of magnetites from other Swedish and international iron ores as well as from various international volcanic materials were also analysed. These additional samples included both "ortho-magmatic" and "hydrothermal" magnetites and thus represent a basis for a comparative analysis with the GMD ore. The combined data and the derived temperatures support a scenario that is consistent with the GMD apatite-iron oxides having originated dominantly (ca. 87 %) through ortho-magmatic processes with magnetite crystallisation from oxide-rich intermediate magmas and magmatic fluids at temperatures of 600 °C to 900 °C. A minor portion of the GMD magnetites (ca. 13 %), exclusively made up of vein and disseminated ore types, is in equilibrium with a high-δ18O and low-δ56Fe hydrothermal fluid at temperatures below 400 °C, indicating the existence of a hydrothermal system associated with the GMD volcano.
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Parolo, Martin. "Marketing challenges for POUS in emerging markets How to tap the BoP-market-segment? /". St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01653047004/$FILE/01653047004.pdf.

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Svärdsudd, Eva. "Omg morsan e fan typ fett schysst : En studie av ungdomars talspråkliga chatkonversationer på sociala medier". Thesis, Högskolan i Gävle, Avdelningen för humaniora, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-21404.

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Syftet med denna uppsats är att undersöka chatkonversationernas talspråkliga uttryck i form av ord och symboler som förstärkning till skriftspråket på sociala medier. De delar som undersöks är akronymer, förkortningar, fula ord, diskurspartiklar, slang, symboler och humörsymboler. Målgruppen för undersökningen är ungdomar på högstadiet och de sociala medier som används är Facebook och Kik. En infallsvinkel till uppsatsen är att undersöka om det kan utläsas någon skillnad i användningen av tillägg hos killar och tjejer. Undersökningen bygger på de chatkonversationer som informanterna själva valt ut och avidentifierat. Resultatet visar att det finns en del värderande skillnader, men också en del likheter, mellan killarna och tjejernas användning av de olika tilläggen. Resultatet visar bland annat att killarna och tjejerna använder fula ord lika frekvent. En stor skillnad är att tjejerna använder betydligt fler symboler (till exempel hjärta och tummen upp) än killarna medan killarna använder fler humörsymboler (smilisar eller emojis).
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Wagner, Sascha Benjamin. "Corporate Governance in Switzerland and Singapore A comparative Case Study of two Government-linked companies /". St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02606176002/$FILE/02606176002.pdf.

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Häggström, Erika, i Margarethe Rehnman. "Livskvalitet och social livssituation hos patienter som genomgått Ö-cellstransplantation". Thesis, Uppsala University, Department of Public Health and Caring Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126374.

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Aim: To investigate the quality of life and the social life situation, with special focus on the consequenses of fear of hypoglycemia (FoH), in Islet transplanted patients.

Method: 11 patients were included, four women and seven men, who have been Islet tranplanted at Uppsala University Hospital during the years 2001-2009. Two questionaires, Short Form 36 (SF-36) and the Swedish version Hypoglycemia Fear Survey (Swe-HFS) were used to investigate the quality of life, in relation to fear of hypoglycemia. Also, telephone interviews were conducted to investigate the patients social life situation in relation to FoH, after Islet transplantation and were analysed using content analysis method.

Results: The mean value for quality of life was lower than that in the normal population. Three out of ten patients experienced FoH. Three predominant themes were revealed, one theme associated with pre- transplant, was “Struggle for control of Social Life Situation” and two themes associated with post-transplant, were “Regain power and controll of  Social Life Situation” and “At Peace with the balance between the Present and the Future”.

Conclusion: The patients experienced improved control over social life situation and quality of life in relation to FoH may been improved following islet tranplantation.


Syfte: Att undersöka ö-cellstransplanterade patienters livskvalitet och sociala livssituation med speciellt fokus på oro/rädsla för hypoglykemi.

Metod: I studien inkluderades 11 patienter, fyra kvinnor och sju män, vilka genomgått ö-cellstransplantation vid Akademiska Sjukhuset i Uppsala under perioden 2001-2009. Två frågeformulär, Short Form 36 (SF-36) och den svenska versionen av Hypoglycemia Fear Survey (Swe-HFS) användes för att undersöka patienternas livskvalitet relaterat till oro/rädsla för hypoglykemi. Telefonintervjuer genomfördes för att undersöka patienternas sociala livssituation efter genomgången ö-cellstransplantation relaterat till oro/rädsla för hypoglykemi och analyserats med innehållsanalys.

Resultat: Medelvärdet för hälsorelaterad livskvalitet var lägre jämfört med normalbefolkningen och tre av tio deltagare upplevde oro/rädsla för hypoglykemi. Tre övergripande teman med koppling till social livssituation identifierades, ett tema före genomgången ö-cellstransplantation, var ”Kampen om kontroll över social livssituation”, och två teman efter genomförd transplantation, var ”Återtagande av makt och kontroll över social livssituation” samt ”Tillfreds med balans mellan nuet och framtiden”.

Konklusion: Patienterna upplevde att kontrollen över den sociala livssituationen och livskvalitet i relation till oro/rädsla för hypoglykemi förbättrades efter genomgången ö-cellstransplantation.

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32

Leroi, Hélène. "International Resources and Capabilities Acquisition by Emerging Multinationals Two case studies of Indian pharmaceutical companies from 1993 to 2008 /". St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/07602709001/$FILE/07602709001.pdf.

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33

Braun, Nils. "Competition in Telecommunications with Two Network Infrastructures Analysis of the efficiency of doubled infrastructures and of effects having differing cost structures - with special regard to the Swiss case /". St. Gallen, 2005. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01648971001/$FILE/01648971001.pdf.

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34

Liu, Bo. "Modélisation d'un cycle de production d'électricité bi-étagé à aéro-réfrigérant sec". Phd thesis, Ecole Nationale Supérieure des Mines de Paris, 2014. http://pastel.archives-ouvertes.fr/pastel-01069070.

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La production d'électricité dépend étroitement de la disponibilité d'une source froide. C'est la raison pour laquelle la plupart des centrales de grande puissance dans le monde sont construites près d'une source d'eau. Le problème de la source froide a été soulevé à plusieurs reprises en France, notamment après les canicules de 2003 et de 2006. Le refroidissement à l'air sec est une des options possibles. Cependant, étant donné le besoin de surface d'échange plus important, le changement de la source froide pour l'air ambiant n'est pas, dans la majorité des cas, viable économiquement.Une des solutions à ce problème imaginées à EDF était de changer l'architecture du cycle de production en considérant un cycle de production composé de deux cycles de Rankine en cascade, le premier fonctionnant avec de la vapeur d'eau et le deuxième fonctionnant avec de l'ammoniac dont la vapeur à basse pression est beaucoup plus dense que celle de l'eau. Cette solution permet de faciliter l'utilisation d'un aérocondenseur et de réduire la taille de la salle machine.En raison de la nature toxique et corrosive de l'ammoniac, il est intéressant d'étudier la possibilité de remplacer ce dernier par d'autres fluides plus adaptés, notamment en envisageant de nouveaux fluides pour lesquels peu ou pas de données sont disponibles. Nous comparons les fluides sur le plan énergétique et en terme de taille des composants de l'installation.Cette thèse illustre la démarche des différentes étapes de notre travail : la recherche de nouveaux fluides de travail, l'évaluation de performance du système en régime nominal et non-nominal, le dimensionnement des principaux composants du cycle ainsi que l'évaluation de coût et de gain économique éventuel.
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35

Mattoso, Verônica de Andrade. "Ora, direis, ouvir imagens?: um olhar sobre o potencial informativo da áudio-descrição aplicada a obras de artes visuais bidimensionais como representação sonora da informação em arte para pessoas com deficiência visual". Universidade Federal do Rio de Janeiro / Instituto Brasileiro de Informação em Ciência e Tecnologia, 2012. http://ridi.ibict.br/handle/123456789/764.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Research about the informative potential of the audio description applied the two-dimensional works of visual arts as sonorous representation of the Information in Art for visually impaired people. Developed by means of a hybrid methodology composed by the approaches of the Evidential Paradigm, the Research-Action and on the basis of the Structural Model for Researches in Plastic Arts and in the Directives of the audio description for Samples and Museums it unfolded in methodological procedures in the which the researcher participated of diverse actions integrated to others agents. The inquiry sets out the extrinsic and inherent aspects of the audio description, considering the dimensions of accessibility physical, methodological, instrumental, communicative, programmatic and of attitudes by which means, the works of art, after being analyzed as sources of information and encoded in structure to assist, they become accessible and available to be accessed. A theoretical study about the stream informational audio description, carried out from the theoretical bases of the Information Science mainly of the Information in Art maintained the structure of the first exposition of two-dimensional works of visual arts with audio description that took place in the State of the Rio de Janeiro. The results of the research refute the distrust and the ignorance as to the informative potential that exists in the access of the visually impaired people to twodimensional standards and reveal contribution of the audio description for the Information Science. As byproduct of the research, documentary was created with content elements that composed the exposition, including the audio description, with plans for the future creation of the first Brazilian database of free access to audio descriptions of two-dimensional works of visual arts
Pesquisa sobre o potencial informativo da áudio-descrição aplicada a obras de artes visuais bidimensionais como representação sonora da Informação em Arte para pessoas com deficiência visual. Desenvolvida por meio de uma metodologia híbrida composta pelos métodos do Paradigma Indiciário, da Pequisa-Ação e com base no Modelo Estrutural para Pesquisas em Artes Plásticas e nas Diretrizes da Áudio-descrição para Mostras e Museus desdobrou-se em procedimentos metodológicos nos quais a pesquisadora participou de diversas ações integrada a outros agentes. A investigação explicita os aspectos intrínsecos e extrínsecos da áudio-descrição, levando-se em consideração as dimensões de acessibilidade física, metodológica, instrumental, comunicacional, programática e atitudinal, por meio dos quais as obras de arte após analisadas como fonte de informação e codificadas em estrutura assistiva são tornadas acessíveis e acessáveis. Um estudo teórico sobre o fluxo informacional da áudio-descrição, realizado a partir dos construtos teóricos da Ciência da Informação principalmente da Informação em Arte sustentou a estrutura da primeira exposição de obras de artes visuais bidimensionais com áudio-descrição realizada no Estado do Rio de Janeiro. Os resultados da pesquisa refutam a desconfiança e a ignorância a respeito do potencial informativo que existe no acesso das pessoas com deficiência visual a padrões bidimensionais e revelam contribuição da áudio-descrição para a Ciência da Informação. Como subproduto da pesquisa foi estruturado um conteúdo documentário formado por elementos que compuseram a exposição, inclusive áudio-descrições, objetivando a criação futura da primeira base de dados brasileira de acesso livre a áudio-descrições de obras de artes visuais bidimensionais
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36

Bidault, François. "Optimisation des séquences IRM et positionnement en carcinologie cervico-faciale de la TEP-IRM". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL060.

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Le bilan d’imagerie des cancers des voies aérodigestives supérieures utilise l’imagerie par résonance magnétique (IRM) et l’imagerie de tomographie par émission de positons (TEP). La TEP-IRM réunit ces deux imageries et permettent (sic) d’envisager l’exploration multiparamétrique des cancers ORL. La mise en place d’un protocole d’imagerie TEP-IRM pose des questions d’instrumentation. Les objectifs étaient de : quantifier et corriger le phénomène d’entrée de coupe artériel sur les séquences IRM de perfusion /perméabilité ; mesurer la précision des cartographies de valeur des temps de relaxation T1 et mesurer le temps de relaxation T1 du cancer ORL ; calculer le taux de détection des nodules pulmonaires par la séquence IRM à temps d’écho zéro (ZTE) et évaluer la précision de la mesure de la taille des nodules pulmonaires ; Comparer les valeurs des indices de texture de la radiomique à 3 Tesla et 1,5 Tesla. L’étude du phénomène d’entrée de coupe et de sa correction a été effectuée avec un imageur 3 Tesla et un fantôme de flux puis chez l’homme. L’étude de la cartographie T1 a été effectuée avec un imageur 3 Tesla et des fantômes de calibration, la mesure du T1 du cancer ORL a été effectuée chez 10 patients. L’étude de la séquence ZTE a été effectué par deux lecteurs avec imageur 3 Tesla en comparaison de la tomodensitométrie (gold standard) chez 12 patients. L’étude des indices de texture a été effectuée avec des imageurs 3 Tesla et 1,5 Tesla et des fantômes faits « maison » avec un logiciel de texture en accès libre et chez 10 volontaires sains. La méthode IRM de présaturation du flux artériel carotidien corrige efficacement l’altération du signal de la fonction d’entrée artérielle liée au phénomène d’entrée de coupe. Son application permet d’envisager de réaliser des acquisitions IRM de perfusion / perméabilité répondant aux recommandations des sociétés savantes en terme de résolution temporelle (inférieure à 5 secondes) tout en étant adaptée à l’anatomie ORL et à la combinaison des imagerie paramétriques. La valeur du temps de relaxation T1 des carcinomes épidermoïdes des VADS est calculée à 1314,5 ms (± 246,1). La réalisation d’une cartographie T1 nécessite la calibration des séquences cliniques à l’aide d’un fantôme et de séquences IRM de référence. Le taux de détection des nodules pulmonaire par ZTE est des 53% (IC95% [48-58]), et de 85% (IC95% [78-92]) pour les nodules de plus de 9 mm. La corrélation entre la taille des nodules avec la séquence ZTE et la taille au scanner est excellente. Les voies d’amélioration de la séquence se portent sur l’augmentation de la résolution spatiale et l’optimisation du contrôle du mouvement respiratoire. Les valeurs des indices de texture en IRM varient avec l’intensité du champ magnétique (3 Tesla versus 1.5 Tesla). Ces résultats contribuent à l’élaboration d’un protocole d’acquisition d’image TEP-IRM en cancérologie ORL. Deux études cliniques loi Jardé 3 sont en cours et utilisent ces résultats. Ces études permettront d’évaluer les performances de l’appareil TEP-IRM et de la combinaison des imageries paramétriques IRM et TEP en carcinologie ORL, ceci avec un haut niveau de preuve histologique
The imaging workup for Head and Neck (ENT) cancers uses magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging. PET-MRI combines these two modalities and makes it possible to consider multiparametric exploration of ENT cancers. The implementation of a PET-MRI imaging protocol raises instrumentation questions.OjectivesThe objectives were to: quantify and correct arterial flow-related enhancement on dynamic contrast-enhanced MRI ; measure the precision of the T1 relaxation times maps and measure the T1 relaxation time of ENT cancer ; calculate the lung nodules detection rate by the MRI zero echo time sequence (ZTE) and evaluate the accuracy of lung nodules size measurement ; compare radiomic features values for different magnetic field strength (3 Tesla versus 1.5 Tesla). The study of the arterial flow-related enhancement and its correction was carried out with a 3 Tesla imager and a flow apparatus, then in humans. The T1 mapping study was performed with a 3 Tesla imager and calibration phantoms, the T1 measurement of ENT cancer was performed in 10 patients. The study of the ZTE sequence was performed by two readers with a 3 Tesla imager in comparison with the computed tomography (CTscan, gold standard) in 12 patients. The study of texture indices was performed with 3 Tesla and 1.5 Tesla imagers and “homemade phantoms”, with an open access texture software and then in 10 healthy volunteers. The MRI saturation method of the carotid arterial flow effectively corrects the alteration of the signal of the arterial input function related to the flow-related enhancement. Its application makes it possible to consider performing MRI perfusion / permeability acquisitions that meet the recommendations of learned societies in terms of temporal resolution (less than 5 seconds) while being adapted to ENT anatomy and to the combination of parametric imaging. The value of the relaxation time T1 of squamous cell carcinoma of the VADS is calculated at 1314.5 ms (± 246.1). Performing T1 mapping requires calibration of clinical MRI sequences using a phantom and reference MRI sequences.The detection rate of pulmonary nodules by ZTE is 53% (CI95% [48-58]), and 85% (CI95% [78-92]) for nodules of size more than 9 mm. The correlation between the size of the nodules with the ZTE sequence and the size on the CTscan is excellent. Areas for improvement of the sequence may focus on increasing spatial resolution and optimizing control of respiratory movement.The values of the texture indices in MRI vary with the intensity of the magnetic field (3 Tesla versus 1.5 Tesla). These results contribute to the development of a protocol for acquiring PET-MRI images in ENT oncology. Two clinical studies are in progress using these results. These studies will make it possible to evaluate the performance of the PET-MRI and of the combination of parametric MRI and PET imaging in ENT cancer, with a high level of histological evidence
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37

Tsopanakis, Georgios. "Different aid paradigm or familiar pattern? : a critical study of two technical cooperation projects of JICA in Ghana". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/different-aid-paradigm-or-familiar-pattern-acritical-study-of-two-technical-cooperationprojects-of-jica-in-ghana(ba9fa145-aaa2-4b47-91dd-32e03952e4b7).html.

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Development aid has long been a major policy tool of the discourse and policy practiceof bilateral and multilateral donors alike. Originally used for servicing the reconstructionof post-war economies and the wider geo-political aspirations of the period, moderndevelopment aid was quickly transformed to an ever-growing industry which hasexpanded to the most remote locations of the globe. Large countries and internationalorganisations swiftly set up a variety of specialised agencies, institutes and researchcentres in order to promote their aid programmes and projects to the poor countries ofthe South. The persistent failure of the development industry to achieve substantialresults in the poorest regions of the world has meant that discourse and priority areashave been redirected multiple times according to the trends of every period. However, itis not clear how far development practice actually alters in correspondence with changesin aid discourse. This dissertation provides an empirical study of the relationshipbetween the two in the context of the move to bottom-up 'partnership' discourse andJapan International Cooperation Agency (JICA) development practise in Ghana. During the last ten years Ghana has geared its development policies towards achievingthe Millennium Development Goals and entering the group of countries classified ashaving (lower) middle-income status. Major donor agencies like JICA have gathered inthe country to provide their 'expertise' and to 'assist' Ghana in reaching the targets ofthe Millennium Declaration. Drawing from two JICA case studies of TechnicalCooperation for Capacity Development in Ghana in health and education this thesissheds light on the differences between JICA's aid rhetoric and practice. This studyargues that despite JICA's aid discourse for a 'demand-driven', 'relevant' and'participatory' aid understanding, its implementation practice contradicts the substantivenormative meanings of these terms and is instead reticent of the past orthodox and 'topdown'aid practices of big donor countries and organisations.
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38

Grahl, Paulo Gustavo de Sampaio. "Essays on Spatial Econometrics". reponame:Repositório Institucional do FGV, 2012. http://hdl.handle.net/10438/11268.

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Esta dissertação concentra-se nos processos estocásticos espaciais definidos em um reticulado, os chamados modelos do tipo Cliff & Ord. Minha contribuição nesta tese consiste em utilizar aproximações de Edgeworth e saddlepoint para investigar as propriedades em amostras finitas do teste para detectar a presença de dependência espacial em modelos SAR (autoregressivo espacial), e propor uma nova classe de modelos econométricos espaciais na qual os parâmetros que afetam a estrutura da média são distintos dos parâmetros presentes na estrutura da variância do processo. Isto permite uma interpretação mais clara dos parâmetros do modelo, além de generalizar uma proposta de taxonomia feita por Anselin (2003). Eu proponho um estimador para os parâmetros do modelo e derivo a distribuição assintótica do estimador. O modelo sugerido na dissertação fornece uma interpretação interessante ao modelo SARAR, bastante comum na literatura. A investigação das propriedades em amostras finitas dos testes expande com relação a literatura permitindo que a matriz de vizinhança do processo espacial seja uma função não-linear do parâmetro de dependência espacial. A utilização de aproximações ao invés de simulações (mais comum na literatura), permite uma maneira fácil de comparar as propriedades dos testes com diferentes matrizes de vizinhança e corrigir o tamanho ao comparar a potência dos testes. Eu obtenho teste invariante ótimo que é também localmente uniformemente mais potente (LUMPI). Construo o envelope de potência para o teste LUMPI e mostro que ele é virtualmente UMP, pois a potência do teste está muito próxima ao envelope (considerando as estruturas espaciais definidas na dissertação). Eu sugiro um procedimento prático para construir um teste que tem boa potência em uma gama de situações onde talvez o teste LUMPI não tenha boas propriedades. Eu concluo que a potência do teste aumenta com o tamanho da amostra e com o parâmetro de dependência espacial (o que está de acordo com a literatura). Entretanto, disputo a visão consensual que a potência do teste diminui a medida que a matriz de vizinhança fica mais densa. Isto reflete um erro de medida comum na literatura, pois a distância estatística entre a hipótese nula e a alternativa varia muito com a estrutura da matriz. Fazendo a correção, concluo que a potência do teste aumenta com a distância da alternativa à nula, como esperado.
This dissertation focus on spatial stochastic process on a lattice (Cliff & Ord--type of models). My contribution consists of using Edgeworth and saddlepoint series to investigate small sample size and power properties of tests for detecting spatial dependence in spatial autoregressive (SAR) stochastic processes, and proposing a new class of spatial econometric models where the spatial dependence parameters that enter the mean structure are different from the ones in the covariance structure. This allows a clearer interpretation of models' parameters and generalizes the set of local and global models suggested by Anselin (2003) as an alternative to the traditional Cliff & Ord models. I propose an estimation procedure for the model's parameters and derive the asymptotic distribution of the parameters' estimators. The suggested model provides some insights on the structure of the commonly used mixed regressive, spatial autoregressive model with spatial autoregressive disturbances (SARAR). The study of the small sample properties of tests to detect spatial dependence expands on the existing literature by allowing the neighborhood structure to be a nonlinear function of the spatial dependence parameter. The use of series approximations instead of the often used Monte Carlo simulation allows a simple way to compare test properties across different neighborhood structures and to correct for size when comparing power. I obtain the power envelope for testing the presence of spatial dependence in the SAR process using the optimal invariant test statistic, which is also locally uniformly most powerful invariant (LUMPI). I have found that the LUMPI test is virtually UMP since its power is very close to the power envelope. I suggest a practical procedure to build a test that, while not UMP, retain good power properties in a wider range for the spatial parameter when compared to the LUMPI test. I find that power increases with sample size and with the spatial dependence parameter -- which agrees with the literature. However, I call into question the consensus view that power decreases as the spatial weight matrix becomes more densely connected. This finding in the literature reflects an error of measure because the hypothesis being compared are at very different statistical distance from the null. After adjusting for this, the power is larger for alternative hypothesis further away from the null -- as one would expect.
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39

Pan, Cheng-Ta. "Electron energy loss spectroscopy of graphene and boron nitride with impurities or defects in the transmission electron microscope". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/electron-energy-loss-spectroscopy-of-graphene-and-boron-nitride-with-impurities-or-defects-in-the-transmission-electron-microscope(c5e574fb-fca6-4ccb-9ebc-60a3ba5c345b).html.

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The two-dimensional material graphene possesses many impressive properties such asextraordinary carrier mobility, mechanical stiffness and optical transmittance. However,the properties of pristine graphene do not always complement the requirements of applications. Of particular interest, a band gap is needed for electronic logic devices. Recent research shows that using few-layer hexagonal boron nitride as a substrate for graphene-based electronic devices can open a band gap in graphene. Also, introducing impurities such as hydrogen atoms, transition metals or silicon atoms on or within graphene can control the electronic properties according to recent studies. Furthermore, ion irradiation is an alternative option to tailor the properties of graphene by introducing defects. In this thesis, pristine, impure or defective graphene and few-layer boron nitride were characterised by scanning transmission electron microscopy (STEM) and electron energy loss (EEL) spectroscopy. Through STEM and EEL spectroscopy, lattice structures and electronic properties of these two-dimensional materials could be investigated at the atomic scale. This thesis focuses on the frontier studies of theoretical and experimental EEL spectroscopy of graphene and few-layer boron nitride with impurities. In the EEL spectra of pristine graphene and boron nitride two prominent peaks were observed, which are attributed to the plasmon excitations of π- and π+σ-electrons. By introducing impurities such as hydrogen adatoms on graphene and substitutional oxygen and carbon atoms within single-layer boron nitride, our experimental and simulated EEL spectra show that their π-plasmon peaks are modified. The concentrations of these impurities were then evaluated via EEL spectra and atomic-resolution images. If other impurities, such as various transition metals and silicon atoms, are introduced on or within single-layer graphene, our simulated EEL spectra demonstrate that the geometry of these impurity clusters affects the π-plasmon peak in graphene and some impurities even enhance it. Finally, experiments on in-situ transmission electron microscopy and ex-situ STEM and Raman spectroscopy were conducted to investigate ion irradiated graphene. Many topological defects were, for the first time, observed in atomic-resolution STEM images of ion irradiated graphene. Simulated EEL spectra of defective graphene are also reported, which suggests that corrugations and dangling bonds in defects can modify out-of-plane EEL spectra and introduce intraband transitions, respectively.
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40

LIN, YUAN-JUN, i 林元俊. "Heat transfer and fluid characteristics of flow passing over two circular tubes arranged in crucif-orm". Thesis, 1992. http://ndltd.ncl.edu.tw/handle/17197163598914840599.

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41

Pai, Tsung-Pin, i 白宗彬. "Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/21066303304338587864.

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博士
國立清華大學
生物科技研究所
101
Memory is initially labile and gradually consolidated over time through new protein synthesis into a long-lasting stable form. Studies of odor-shock associative learning in Drosophila have established the mushroom body (MB) as a key brain structure involved in olfactory long-term memory (LTM) formation. Exactly how early neural activity encoded in thousands of MB neurons is consolidated into protein-synthesisdependent LTM remains unclear. Here, several independent lines of evidence indicate that changes in two extrinsic MB-output (MB-V3) neurons are required and contribute to an extended neural network involved in olfactory LTM: (i) inhibiting protein synthesis in MB-V3 neurons impairs LTM, (ii) MB-V3 neurons show enhanced neural activity after spaced but not massed training, (iii) MB-V3 dendrites, synapsing with hundreds of MB α/β neurons, exhibit dramatic structural plasticity after removal of olfactory inputs, (iv) neurotransmission from MB-V3 neurons is necessary for LTM retrieval and (v) RNAi-mediated downregulation of oo18 RNA-binding protein (ORB) in MB-V3 neurons impairs LTM. Our results suggest a model of long-term memory formation which includes a systems-level consolidation process, wherein an early, labile olfactory memory represented by neural activity in a sparse subset of MB neurons is converted into a stable LTM through protein synthesis in dendrites of MB-V3 neurons synapsed onto MB α-lobes.
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42

Hsieh, Cheng-Han, i 謝承翰. "Understanding Usage Transfer Behavior of Two Way O2O (Online-to-Offline and Offline-to-Online) Services". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/ssnes8.

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碩士
國立中興大學
資訊管理學系所
103
Owing to the advances and the prevalence of information technology, the worldwide network has already become part of life. With the rapid increase of internet users, e-commerce is also striving to become the mainstream of current business activities. Regardless of the scale of the enterprises, the e-market has already become a force that should not be overlooked. In addition to the already existing business models, such as B2B, B2C, C2B and C2C, O2O is also in rapid development in recent years. Compare with the path O2O researches, most researches concentrated on a single application of O2O to explore user intention. This study aims to understand if consumer experiences and behaviors can be transferred to the other side between Online and Offline, and find the O2O marketing mode in the key factors that influence consumer behavior. In this study, we adopt a questionnaire surveys which consist of Online-to-Offline and Offline-to-Online for data collection on the internet. According to consumers past involved into O2O marketing mode of experience and views for fill answer. This study integrates “Trust”, “Perceived Risk”, “Subjective Norm”, “Perceived Interaction”, “Convenience”, “Service Quality”, “Satisfaction” and “Behavior Intention” as a research model and for follow-up analysis and discussion. This study integrates Technology Acceptance ModelⅡ (TAMⅡ), Information System Success Model (ISSM) and other external variables to establish hypotheses. Structural equation modeling (SEM) is used for result analysis and verification. The empirical results reveal that (1) In Online-to-Offline mode, trust, perceived risk, service quality, subjective norms and convenience have significant positive influence over consumers’ system satisfaction and behavior intention, but perceived interaction isn’t significantly associated with system satisfaction. (2) In Offline-to-Online mode, trust, service quality, perceived interaction, subjective norms and convenience have significant positive influence over consumers’ system satisfaction and behavior intention, but perceived risk isn’t significantly associated with behavior intention. Moreover, this study provide practical references for the O2O enterprises as marketing adjustment, so their strategical applications are satisfying the demands of the targeted customers. In this way, they can also increase the targeted user’s intention to use the product and obtain real benefits.
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L'Heureux, Elizabeth Clare. "Investigation into the scattering response of mineral ore deposits in heterogeneous environments by means of two-dimensional and three-dimensional seismic modelling". 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742535&T=F.

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Brožová, Ladislava. "Téma manipulace v literatuře". Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-323092.

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The theme of this diploma thesis is the manipulation in literature as a dialog between the I and the You or the I and the It. This I has a different position in each of the two types of manipulation. In the first type the I is the subject of manipulation - that is a manipulator. In the second one the I becomes the object of manipulation - thus a victim of a manipulator because the power over the I has been overtaken by other character's consciousness. The I and the You type is represented by an outside dialog (between characters), whereas the I and the It type is demonstrated in an inside dialog which does not occur between the hero and another character but between the hero and a voice of other character's consciousness. The opening part which deals with the manipulation in different contexts (philosophical, political and psychological) is followed by a part where I interpret the manipulation's representation in literature, especially in the works of Dostojevskij (The Double, The Village of Stepanchikovo, Notes from Underground, The Eternal Husband). With the characters of this author we can view the dark side of the human mind and also have a close look at various forms of arbitrariness, especially at the manipulation with the others.
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Banda, Nelson. "Evaluation of two different mechanized earth moving technologies truck and shovel and IPCC for handling material from a large open pit mine using requesite design and operational conditions, efficiency, cost , skills and safety as criteria using sishen iron ore mine as a case study". Thesis, 2016. http://hdl.handle.net/10539/20589.

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An advanced coursework and a project submitted to the Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements of MSc. Engineering (Mining), November 2015
General For mining operations, both underground and open cast, there are generally accepted criteria used to arrive at the optimum mining method with which to exploit the ore body economically. Having selected the optimum mining method, mining companies should then make the decision to also select the optimum technology to apply given the various options that are now available. In the case of a shallow massive ore body where open-pit mining has been selected as the optimum mining method, the use of conventional trucks and shovels has been the popular choice but over the years, as pit become deeper, and stripping ratios increase, growing interest and adoption of in-pit crushing and conveying for both ore and waste has been gaining ground with several mining sites currently now operating, testing the systems or conducting studies at various stages for In-pit Crushing and Conveying (IPCC) in its different configurations (Chadwick, 2010). Open pit mining general involves the movement of pre-blasted or loose waste ahead of underlying ore out of the pit or to a previously mined part of the pit. This is then followed by the drilling and blasting or loosening of the ore and transportation to the processing plant or stockpiles. The conventional Truck and Shovel open pit operation involves the use of shovels – electric rope shovels, diesel or electric hydraulic shovels or excavators or front-end loaders to load the blasted, or loose waste and ore material in the pit onto mining trucks which haul the material to crushers or stockpiles if it is ore or to waste dumps in the case of waste. In a Fully Mobile IPCC (FMIPCC) system, the broken or loose material in the pit is loaded into a crusher or sizer by a shovel, continuous miner or dozer, crushed to a manageable size and transported by conveyor belts to the waste dump where it is deposited in place using spreaders if it is waste or onto stockpiles if it is ore. A combination of the two systems is where trucks dump material loaded at the face into a semi mobile crusher or sizer located in the pit close to the loading points N BANDA 392438 before conveying to destination thereby reducing truck haulage distance. In the semi-mobile configuration, the crusher is relocated closer to the loading points to minimise the hauling distance. Other various configurations are also employed depending on the various considerations. Although the Truck and Shovel system is considered as the convention in open pit mining, the IPCC system is not a new concept and has been operational on a number of mines worldwide for quite a number of years (Szalanski, 2010). Loading and hauling receive great attention especially in a high volume open pit mines due to the high cost contribution to the overall operation and therefore, if optimised, good cost savings can be realised (Lamb, 2010). Figure 1: Sishen Mining Cost Breakdown In the case of Sishen Loading and Hauling costs constituted 67% of the mining costs including labour mining support services in 2013 (Kumba Iron Ore, 2013). This picture remains unchanged to a large extent. In some cases the hauling cost alone can make up as much as 60% of the mining operating cost (Meredith May, 2012) Selection of a materials handling system between Truck and Shovel (T/S) and In-pit Crushing and Conveying (IPCC) has proven to be difficult due to limited understanding of the IPCC system especially its advantages and disadvantages relative to the Truck and Shovel system. The aim of this research was to unpack these two systems in terms of their applicability using studies conducted at Sishen 6,5% 8,8% 29,1% 22,7% 9,7% 0,6% 1,3% 0,4% 7,0% 4,2% 3,7% 5,9% Sishen Mining Cost 2013 Blasting Drilling Hauling L&H Contractors Loading Maintenance Other Mining Manangement Mining Engineering Mining Other Resource Management SHEQ Mining Support N BANDA 392438 Mine as well as develop some scorecard that could be used to select one over the other one. Sishen Case Study Sishen Mine is an iron ore open pit mine located in the Northern Cape province of South Africa and is part of Kumba Iron Ore Company which is Anglo American PLC. The mine has been in operation since 1953 with the current life of mine going up to 2030. It produces 44Mt tonnes of product from a 56Mt mine ore at a life of mine strip ratio of 4. One of the planned expansion the north part of the mine known as the GR80 and GR50 areas. Mining in these areas will require pre-stripping of 290Mt of clay material over the life of mine to expose the ore in pre volume phases. Figure2: Sishen Pit –Sishen Mine 2014. Sishen mine is constantly evaluating various technologies in its mining operations aimed at improving its bottom line by way of increasing productivity and efficiency, reducing costs and improving safety, however, the last time that the mine considered evaluating a technology that significantly could have resulted in a totally different operational philosophy was i contracted to institute a study to evaluate technology options for mining and moving majority owned by a minimum of 437Mt of calcrete and the underlying pre- g in 2007 when Snowden Mining Consultants run-ofmine areas is in -planned time and were N BANDA 392438 55 Mt of the calcrete/clay material per year from the waste pushback area in the GR80/GR50 area of the mine from 2009 till 2030. Snowden completed the Prefeasibility study in early 2008 in which they evaluated a conventional Truck and Shovel operation as well as IPCC. Economic viability of both systems in various configurations was demonstrated with the use of larger trucks and shovels ranked as the most economic option in terms of Net Present Cost (NPC), unit owning and operating cost per mined tonne and, to a less extent, in terms of risk and other considerations. In this case, the Truck and Shovel option was more economic than both IPCC configurations. However the small difference in the cost figures gave rise to interest in further evaluations. Following the Snowden study, Sishen engaged Sandvik Mining and Construction in 2008, to review the work done by Snowden and provide more detail and practical input to the IPCC system at scoping level. In the review, the IPCC system was shown to be the economic approach for the waste removal from the target area in terms of owning and operating cost. Practicality was also demonstrated and the case for the consideration of the IPCC system was put forward to Sishen. A further consultant, Sinclair Knight Merz (SKM) of Australia, was engaged, in the later part of 2008, to further evaluate and optimise the IPCC option to further demonstrate practically in detail at a feasible study level and strengthen its case by mitigating perceived risk. This included equipment specifications, mine and equipment layout per period per bench and risk assessment on the IPCC options. The mine, however, implemented the conventional truck and shovel option using larger equipment. The final decision was to stick with the current set up of Truck and Shovel system and gradually replace the current fleet of 730E Komatsu (190 tonne payload) trucks with the 930E or equivalent ( 320 tonne payload) and the current XPB 2300 P& H electric rope shovels and CAT 994/Komatsu WA1200 front end loaders with XPC 4100 P&H electric rope shovels, Komatsu PC8000/Liebherr 996 diesel hydraulic shovels and LeTournea L-2350 front end loaders to reduce the number of equipment and manage the operational cost. This decision was based on issues around initial capital investment, flexibility of the system to suit changing mining plans, ability of current personnel to run the system and general low risk appetite for change. The adopted option has its own challenges N BANDA 392438 such as supporting infrastructure requirements, labour intensity and associated low productivity and high cost, fleet management challenges to achieve required productivity constantly, supplies such as fuel and tyres and safety issues due to traffic density. A high level recalculation of the costs using current information was done as part of this research. For simplicity, no escalations or discounting were applied on future expenditure. The estimated unit owning and operating costs in 2014 terms for the study area were as follows:- Fully Mobile IPCC (FMIPCC) option ZAR 10.38/t, Semi Mobile IPCC (SMIPCC) option ZAR 13.12/t, Truck and Shovel option ZAR 15.80/t. The objective of this research is to use lessons from the Sishen case as well as other operations and gather expert views with the aim of establishing criteria that could be applied in a preliminary evaluation that would determine the suitability of either of the materials handling options. General Approach The costs were recalculated using as much current information as possible. Other considerations including advantages and disadvantages of either of the systems were examined in more detail, with real life examples examined where possible. This resulted in the establishment of generalized criteria for the selection of mining and transport technology for a large open pit mine with focus on conventional Truck and Shovel systems on one hand and IPCC systems, in their various formats, on the other. These criteria which identify conditions necessary for the successful adoption and implementation of either of the systems could then be used as input into the decision to carry out any further detailed studies of the options. The previous study reports on the Sishen mine case were examined, input parameters to the calculations checked and the general approached analyzed for practicality. The relative costs were also viewed for comparative purposes. Literature on these two main systems was reviewed including that from conferences. Other large operations running either one or both systems were looked at to gain N BANDA 392438 further insight. Original Equipment suppliers’ views on these systems were also looked at through many articles in the public domain. Sishen mine has previously had the IPCC system running in the same part of the mine in a semi mobile configuration, crushing and conveying waste. It was then changed to become a supplementary system for the ore handling system and the in pit crusher has never been relocated. The Truck and Shovel system took over the movement of all the waste and most of the ore at the mine. Lessons from these experiences were incorporated in this study.
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