Gotowe bibliografie tematyczne / Osteoarthritis – Degenerative changes

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Gotowa bibliografia na temat „Osteoarthritis – Degenerative changes”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Osteoarthritis – Degenerative changes"

Tae, Ilho, Yunheon Song, and Youn Joong Kim. "Clinical importance of TMJ Osteoarthritis in Dental Practice." Journal of The Korean Dental Association 51, no. 2 (2013): 92–98. http://dx.doi.org/10.22974/jkda.2013.51.2.003.

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Osteoarthritis is one of the most common degenerative disease in the temporomandibular joints(TMJ). Structural changes in the osseous structure is associated with destructive changes such as erosion, flattening and other bony changes. Destructive degenerative changes quite often cause shortening of the condyles which eventually produces the changes in the occulsion and the facial profile which require orthorgnathic surgery and/or orthodontic treatment by the dental professional. The dentists need to understand the nature and the pathophysiology of the osteoarthritis in the TMJ for the better d

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Kątniak, Anna, Joanna Podladowska, Joanna Wawrzeniuk, Jacek Tomczyk, Zbigniew Wyżewski, and Anna Myszka. "Osteoarthritis in early modern population from Dąbrówki (Podlaskie Province)." Anthropological Review 85, no. 3 (2022): 83–94. http://dx.doi.org/10.18778/1898-6773.85.3.06.

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The aim of this analized is to evaluate the frequency of osteoarthritis in the early modern population of Dąbrówki (Poland). Evaluation of degenerative joint changes was based on standard methods commonly used in physical anthropology. Three types of changes were studied: osteophytes, porosities, and eburnations. They were analyzed in the shoulder, elbow, wrist, hip, knee, and proximal ankle joints. Osteoarthritic changes were assessed in 24 female, 20 male, and 8 undetermined sex individuals in the Dąbrówki population. In the population from Dąbrówki the highest frequency of degenerative chan

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Walewska, Ewa. "Efficacy of the use of unsaponifiable fractions of avocado and soybean oil in osteoarthritis." Medycyna Faktów 14, no. 2 (2021): 188–92. http://dx.doi.org/10.24292/01.mf.0221.8.

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Osteoarthritis, which affects approximately 18% of women and 10% of men after the age of 60, is undoubtedly a serious public problem. The main pathological changes in osteoarthritis include the degeneration and loss of articular cartilage, changes in the subchondral bone and osteophyte formation in the bone epiphyses. Pain accompanying degenerative modifications significantly reduces the quality of life of patients. The purpose of this article is to discuss the use of unsaponifiable fractions of avocado and soybean oil to control the symptoms of osteoarthritis of the knee on a case-by-case bas

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Piombino-Mascali, Dario, Fausto Grimaldi, Aldo Liberto, Federica Ministeri, Federico Privitera, and Cristoforo Pomara. "Flectamus genua. Gonarthrosis in the Remains of the Blessed Giuseppe Benedetto Dusmet (Catania, Italy, 19th Century AD)." Acta medica Lituanica 32, no. 1 (2025): 236–43. https://doi.org/10.15388/amed.2025.32.1.24.

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Introduction: This study investigates the bioanthropological and paleopathological features of the late Blessed Giuseppe Benedetto Dusmet, a revered 19th-century archbishop of Catania. Dusmet’s remains were examined during the most recent canonical recognition in 2021, providing an opportunity to study the skeletal characteristics that may reflect his lifestyle and health.Materials and methods: Paleopathological analysis focused on degenerative changes using macroscopic inspection to identify osteoarthritic conditions. Historical records were also consulted to understand the potential connecti

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Kim, Dong Hyun, Seong Chan Kim, Ji Soo Yoon, and Yong Seuk Lee. "Are There Harmful Effects of Preoperative Mild Lateral or Patellofemoral Degeneration on the Outcomes of Open Wedge High Tibial Osteotomy for Medial Compartmental Osteoarthritis?" Orthopaedic Journal of Sports Medicine 8, no. 6 (2020): 232596712092748. http://dx.doi.org/10.1177/2325967120927481.

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Background: Early osteoarthritis of the knee joint mostly affects the medial compartment, making osteotomy a rational approach to slow the progression of the disease. However, some patients show asymptomatic mild degeneration in the lateral or patellofemoral compartment. Purpose: To evaluate the effect of asymptomatic mild lateral or patellofemoral degeneration on the outcomes of medial open wedge high tibial osteotomy (OWHTO) by assessing the outcomes according to the preoperative status of the lateral or patellofemoral degenerative changes. Study Design: Cohort study; Level of evidence, 3. M

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Yamamoto, K., T. Shishido, T. Masaoka, and A. Imakiire. "Morphological Studies on the Ageing and Osteoarthritis of the Articular Cartilage in C57 Black Mice." Journal of Orthopaedic Surgery 13, no. 1 (2005): 8–18. http://dx.doi.org/10.1177/230949900501300103.

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Purpose. To study the cause and mechanism of joint degeneration in osteoarthritis, through histopathological and ultrastructural-histochemical experiments on the articular cartilage of the knees of the C57 black mouse. Methods. 192 C57 black mice and a control group of 64 C57BL/6J mice were used in this study. The left and right knee articular capsules of the joints were removed and stained. Each articular cartilage sample was examined and osteoarthritic changes were assessed using a transmission electron microscope. The severity of osteoarthritis in the knee joint cartilage of C57 black mice

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Pattugayathri, S., B. G. Harshavardhan, V. Poongodi, and K. Saraswathi Gopal. "Prevalence of Temporomandibular Joint Osteoarthritic Changes Using Cone-beam Computed Tomography in South Indian Population." Journal of Head & Neck Physicians and Surgeons 11, no. 2 (2023): 83–89. http://dx.doi.org/10.4103/jhnps.jhnps_50_23.

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Introduction: Osteoarthritis of temporomandibular joint (TMJ) is a chronic degenerative joint disease characterized by synovitis, cartilage destruction, and subchondral bone remodeling and it is an age-related disorder. Cone-beam computed tomography (CBCT) is used for diagnosis of degenerative changes in TMJ, at the same time ensuring lower radiation dose, a shorter exposure time, and a higher spatial resolution. Aim and Objectives: The aim of the study is to evaluate the prevalence of osteoarthritic changes of TMJ using CBCT. Materials and Methods: One hundred fifty CBCT images were collected

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Dąbrowski, Mikołaj, Anetta Zioła-Frankowska, Marcin Frankowski, Jacek Kaczmarczyk, and Łukasz Kubaszewski. "Comparison of Bone Tissue Trace Element Content in the Different Radiological Stages of Hip Osteoarthritis." International Journal of Environmental Research and Public Health 18, no. 6 (2021): 3260. http://dx.doi.org/10.3390/ijerph18063260.

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Bone metabolism and the trace element content associated with it change at each stage of degenerative disease. The aim of this study was to find out about the role of the analyzed elements in different stages of hip osteoarthritis. Elements associated with oxidative and enzymatic processes were analyzed depending on the changes in the radiological images of the hip joint. Element content analysis was performed by the inductively coupled plasma mass spectrometry analytical technique. The femoral head in severely osteoarthritic hips (KL3–4) compared to mild grade osteoarthritis (KL2) had a great

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Konstantin, Aminkov. "REGENERATIVE THERAPIES FOR TREATMENT OF OSTEOARTHRITIS (OA) IN DOGS. REVIEW." TRADITION AND MODERNITY IN VETERINARY MEDICINE 4, no. 2 (2019): 81–85. https://doi.org/10.5281/zenodo.3234127.

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Osteoarthritis is a degenerative joint disease characterized by destructive changes in articular cartilage and formation of new bone tissue - osteophytes. OA is the most common degenerative joint disease in humans and animals. OA affects the entire joint and is characterized by inflammation, remodeling of bones and progressive destruction of constitutive cartilage components.The main purpose in the treatment of osteoarthritis is aimed at relieving pain, maintaining joint mobility, improving the quality of life of the patient, slowing down the development of degenerative changes. Over the last

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Ekeuku, Sophia Ogechi, Fairus Ahmad, and Kok-Yong Chin. "Changes of Grip Strength, Articular Cartilage and Subchondral Bone in Monoiodoacetate-Induced Osteoarthritis in Rats." Sains Malaysiana 51, no. 11 (2021): 3741–54. http://dx.doi.org/10.17576/jsm-2022-5111-18.

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Osteoarthritis is a degenerative disease affecting articular cartilage among the elderly. The intra-articular monoiodoacetate injection is one of the most widely used methods to induce osteoarthritis in animals. While the effects of monoiodoacetate on cartilage are well-characterized, its effects on subchondral bone remodeling are less studied. The purpose of this study was to determine the changes of the grip strength, articular cartilage structure and subchondral bone remodeling in monoiodoacetate-induced osteoarthritis in rats. Three-month-old male Wistar rats were assigned to normal contro

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Książki na temat "Osteoarthritis – Degenerative changes"

Warwick, David, Roderick Dunn, Erman Melikyan, and Jane Vadher. Osteoarthritis of the hand. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199227235.003.0009.

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Introduction 254Digital joint replacement 256Scaphoid–trapezium–trapezioid joint 258Thumb CMCJ arthritis 260Non-operative treatment for thumb CMC OA 262Operative treatment for thumb CMCJ OA 264Finger carpometacarpal joint 269Metacarpophalangeal joint 270Proximal interphalangeal joint 272Distal interphalangeal joint 274Common disease of diarthrodial joints. Primary aetiology is characterized by progressive degeneration of articular cartilage: a manifestation of an abnormal state of chondrocyte metabolism, loss of certain tissue components, alterations in microstructure and changes in biomechani

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Części książek na temat "Osteoarthritis – Degenerative changes"

Ngo, Khoa, Nathaniel T. Herrera, Milda Folkmanaite, Kei Yamamoto, and Mary M. Maleckar. "In silico Investigation of Sex-Specific Osteoarthritis in Human Articular Chondrocytes." In Computational Physiology. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-25374-4_3.

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AbstractOsteoarthritis (OA), a progressive degenerative disease of cartilage in joints, is the most common cause of chronic disability in older adults. While OA is mostly considered an age-related pathology, women have a 1.5-fold higher risk of developing OA relative to men and experience more severe symptoms. Yet, they remain underrepresented in musculoskeletal research and clinical trials. Responsible for cartilage formation, articular chondrocytes experience physiological changes in OA, but the functional implications of such alterations remain largely unexplored due to difficulties in acqu

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Naish, Josephine H., Graham Vincent, Mike Bowes, et al. "A Method to Monitor Local Changes in MR Signal Intensity in Articular Cartilage: A Potential Marker for Cartilage Degeneration in Osteoarthritis." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2004. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30136-3_116.

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Silman, Alan J., and Marc C. Hochberg. "Osteoarthritis." In Epidemiology of the Rheumatic Diseases. Oxford University PressNew York, NY, 1993. http://dx.doi.org/10.1093/oso/9780192623560.003.0011.

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Abstract Osteoarthritis, also referred to as osteoarthrosis and degenerative joint disease, is the most common form of arthritis (Kelsey and Hochberg 1988, 1992). Prior to 1986, no standard definition of osteoarthritis existed; most authors described osteoarthritis as a disorder of unknown aetiology in which articular cartilage and subchondral bone were primarily affected in contrast to rheumatoid arthritis which primarily affects the synovial membrane. A standard definition of osteoarthritis, developed by the Subcommittee on Osteoarthritis of the American College of Rheumatology Diagnostic an

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Al-Dadah, Khalid, and Sherif El-Tawil. "Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis." In 50 Studies Every Orthopaedic Surgeon Should Know. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780190096656.003.0028.

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Abstract Meniscal tears in the knee are a common pathology and often occur concurrently with osteoarthritic changes. A diagnostic challenge is whether or not to address the meniscal tear surgically in a patient with degenerative changes within the knee. A multicenter and randomized controlled trial is presented with 351 patients aged older than forty-years years presenting with symptomatic meniscal tears and evidence of mild to moderate osteoarthritis (OA) on imaging. Group one received arthroscopic meniscectomy and physiotherapy. Group two received physiotherapy alone. The primary outcome was

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Ernste, Floranne C. "Osteoarthritis, Gout, and Inflammatory Myopathies." In Mayo Clinic Internal Medicine Board Review, 12th ed., edited by Christopher M. Wittich, Thomas J. Beckman, Sara L. Bonnes, et al. Oxford University PressNew York, 2019. http://dx.doi.org/10.1093/med/9780190938369.003.0082.

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Abstract Osteoarthritis is the failure of articular cartilage and the subsequent degenerative changes in subchondral bone, bony joint margins, synovium, and para-articular fibrous and muscular structures. Osteoarthritis is the most common joint disease. Of patients, 80% have some limitation of their activities, and 25% are unable to perform major activities of daily living. As a consequence, osteoarthritis is a substantial economic burden to society. The prevalence of osteoarthritis is strongly associated with aging. Joints most commonly affected are the knee, hand, spine, metatarsophalangeal,

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Manek, Nisha J., and Alex J. MacGregor. "Imaging in osteoarthritis." In Imaging in Rheumatology. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780192632630.003.0015.

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Abstract Osteoarthritis is one of many synonymous terms used to describe a group of conditions affecting synovial joints. Although often referred to as ‘degenerative’, osteoarthritis (OA) is a dynamic phenomenon that reflects the balance between joint tissue destruction and repair. The clinical and radiographic features in any affected joint are determined by the relative vigour of these opposing processes. It is more process than disease, occurring in almost any condition that causes a disparity between mechanical stress applied to articular cartilage and the ability of the cartilage to withs

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Jean, N’Dre, Hamideh Salehi, Marie Maumus, Danièle Noël, Yolande Koffi-Gnagne, and Frédéric Cuisinier. "Characterization of Degraded Cartilage Using Confocal Raman Microscopy." In Cartilage - Recent Findings and Treatment [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.107310.

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Osteoarthritis is a degenerative disease with pathological changes at the molecular level. Moreover, the damage to articular cartilage is irreversible. Early detection and the ability to follow the progression of osteoarthritis are essential to anticipate management. To characterize degraded human articular cartilage and to identify cellular changes that are precursors of phenotypic matrix changes in osteoarthritis, normal and degraded articular cartilage explants were harvested from the same patient’s knee after informed consent. The blocks were washed several times (four times) with phosphat

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Michet, Clement J. "Rheumatoid Arthritis and Spondyloarthropathies." In Mayo Clinic Internal Medicine Board Review. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190464868.003.0080.

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Osteoarthritis is the failure of articular cartilage and subsequent degenerative changes in subchondral bone, bony joint margins, synovium, and para-articular fibrous and muscular structures. Osteoarthritis is the most common joint disease; 80% of patients have some limitation of their activities, and 25% are unable to perform major activities of daily living. Hyperuricemia occurs in 2% to 18% of normal populations. It is associated with hypertension, renal insufficiency, obesity, and arteriosclerotic heart disease. Clinical gouty arthritis ranges in prevalence from 0.1% to 0.4%; it is the mos

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Englmeier K.-H., Siebert M., Stammberger T., et al. "Quantitative Image Analysis of the Cartilage in Virtual Reality." In Studies in Health Technology and Informatics. IOS Press, 2002. https://doi.org/10.3233/978-1-60750-929-5-141.

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The objective of this work is to develop image processing methods for analysing the morphology of the joint cartilage with magnetic resonance imaging. Quantitative data on the morphological distribution of the joint cartilage are of great interest for both research as well as for diagnosis. The cartilage thickness provides information on the local cartilage occurance and may therefore be helpful in early and objective diagnosing degenerative cartilage changes, monitoring the pathogenesis of osteoarthritis, and controlling the success of chondroprotective treatment. In biomechanics, the thickne

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Stefan Cristian, Dinescu, Ionescu Razvan Adrian, Popoviciu Horatiu Valeriu, Avram Claudiu, and Vreju Ananu Florentin. "Musculoskeletal and Nerve Ultrasonography." In Ultrasound Imaging - Current Topics [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102640.

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Musculoskeletal ultrasound had gained more and more importance lately and there is no doubt now about its role in the diagnosis and management of rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, osteoarthritis and crystal related arthropathies. We can say that now, US is a widely available, non-invasive, and cost-effective technique suitable for the evaluation of the articular and periarticular structures, such as joints, tendons, muscles, ligaments, and bursa. The real-time capabilities of the US allow continuous observation of those structures during movement and of the ne

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Streszczenia konferencji na temat "Osteoarthritis – Degenerative changes"

Asaoka, Ryuji, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, and Yusuke Oshima. "Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy." In Multiscale Imaging and Spectroscopy IV, edited by Kristen C. Maitland, Darren M. Roblyer, and Paul J. Campagnola. SPIE, 2023. http://dx.doi.org/10.1117/12.2650088.

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Oshima, Yusuke, Hiroshi Kiyomatsu, Hiromasa Miura, Yasumitsu Ishimaru, and Kazunori Hino. "Evaluation of degenerative changes in articular cartilage of osteoarthritis by Raman spectroscopy." In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2018. http://dx.doi.org/10.1117/12.2291383.

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Chan, D. D., and C. P. Neu. "Human Tibiofemoral Joint Displacements Determined by Displacement-Encoded MRI." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53498.

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Articular cartilage and surrounding soft tissues in the knee are important to normal joint function. Osteoarthritis (OA) is highly prevalent in the United States [1] and features precocious degeneration of articular cartilage. Effective OA treatments require the ability to detect early degeneration, including mechanical and biochemical changes. Magnetic resonance imaging has shown promise for the detection of early degenerative changes, including various quantitative MRI techniques [2]. Displacement-encoded MRI has the ability to detect changes in mechanical behavior, and such techniques have

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Bevill, Scott L., Ashvin Thambyah, and Neil D. Broom. "Altered Micromechanical Function Precedes Overt Surface Roughening in Early Cartilage Degeneration." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53139.

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The proper biomechanical functioning of articular cartilage in the joint is highly dependent on the composition and structure of the tissue. In the earliest stages of both osteoarthritis (OA) and age-related cartilage degeneration there are dramatic compositional and structural changes that occur within the general matrix. With these changes in matrix content and structure comes impaired biomechanical functioning [1]. A number of studies suggest that destructuring of the fibrillar collagen network (e.g., altered organization and loss of fibrillar interconnectivity) may be the initiating event

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Linder-Ganz, Eran, Jonathan J. Elsner, Gal Zur, et al. "Chondroprotective Effects of a Polycarbonate-Urethane Meniscal Implant: Semi-Quantitative Results in a Sheep Model." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19048.

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The menisci play a critical role in load-bearing and stability of the knee joint [1]. Damage or removal of the meniscus leads to alterations in the magnitude and distribution of stresses in the knee, which have been associated with degenerative osteoarthritis [2]. Clearly, there remains a need to develop means of protecting the articular cartilage following meniscal injury by either repairing or replacing the menisci. While allograft meniscal replacements can improve joint stability and function, they often provide little benefit in preventing osteoarthritic changes [3]. The development of an

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Ling, Carrie H., Janice H. Lai, James F. Nishimuta, and Marc E. Levenston. "Dose-Dependent Effects of Interleukin-1Alpha on Functional Degradation of Lateral and Medial Menisci." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19523.

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Despite a growing recognition that meniscal degeneration often precedes cartilage degeneration in the development of knee osteoarthritis (OA), little is known about the role of meniscal degeneration in the onset and progression of knee OA. Even a mild degenerative lesion increases meniscal extrusion, implying changes in biomechanical function. Understanding the mechanisms of meniscal degeneration may enable the diagnosis and disease-modifying treatment of early knee OA, potentially preventing or slowing the progression of the disease. The roles of pro-inflammatory cytokines such as interleukin

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Soltz, Michael A., Mathew F. Koff, Eric J. Balaguer, et al. "A Device for Evaluating Laxity of the Thumb Carpometacarpal Joint." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2556.

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Abstract It has been proposed that ligamentous laxity promotes osteoarthritis of the thumb carpometacarpal joint. However, quantitative measurements of laxity for this joint have not been correlated with its incidence of osteoarthritis nor with other measures of degenerative changes such as joint congruence, surface remodeling, cartilage mechanical properties or biochemical composition. The goal of this study was to design and build a device for testing the laxity of the carpometacarpal joint, with the long-term aim of advancing our understanding of the etiology of osteoarthritis in this joint

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Vernon, Lauren L., David G. Wilensky, Chong Wang, Lee D. Kaplan, and Chun-Yuh C. Huang. "Mechanical Loading Reduces Chondrocyte Death After Single Impact Trauma: Porcine Knee Model." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80833.

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Osteoarthritis often results from degenerative changes induced by trauma such as joint impact injuries sustained during athletics, combat, or motor vehicle accidents. Articular cartilage, avascular in nature, relies of synovial nutrition [1] and lacks sufficient regenerative capabilities [2]. Acute cartilage injuries have been shown to induce cell death [3, 4, 5], leading to reduced chondrocyte density and degenerative changes to the cartilage matrix composition; over time the tissue becomes compromised and loses its ability to maintain and restore itself. It has been demonstrated, that mechan

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Murienne, Barbara J., Michael J. Girard, Lise Loerup, et al. "An Automated Histologic System for 3D Histomorphometry of the Mouse Knee." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53443.

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Osteoarthritis (OA) is a degenerative joint disease that is a leading cause of adult pain and disability in Western countries1. Clinically, several structural features of the joint are important in diagnosis, prognosis and evaluation of treatment efficacy, e.g. cartilage volume, homogeneity and joint space narrowing2,3. In animal models of OA, structural features such as bone defects and cartilage changes are commonly investigated using histomorphometry, a technique that uses stereological point counting and manual tracing of regions of interest to extract 3-dimensional (3D) geometrical proper

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Dumitriu, Antonina, and Valeriu Enciu. "Screening methods of coxofemural dysplasia in dogs." In Xth International Conference of Zoologists. Institute of Zoology, Republic of Moldova, 2021. http://dx.doi.org/10.53937/icz10.2021.53.

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The major desideratum of the screening action of the hip dysplasia is the early discovery of the disease and its highlighting at an early stage. Hip dysplasia is interpreted as an abnormal and / or defective development of the hip (hip joint), which can cause excessive wear of the articular cartilage due to the support of body weight leading to the development of arthritis, often called degenerative joint disease or simply osteoarthritis, these terms being used randomly. All these morphofunctional changes can be detected early, by different methods of observation, which necessarily involve X-r

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Raporty organizacyjne na temat "Osteoarthritis – Degenerative changes"

MR MSK Cartilage for Joint Disease, Consensus Profile. Chair Thomas Link and Xiaojuan Li. Radiological Society of North America (RSNA) / Quantitative Imaging Biomarkers Alliance (QIBA), 2021. http://dx.doi.org/10.1148/qiba/20210925.

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The goal of a QIBA Profile is to help achieve a useful level of performance for a given biomarker. The Claim (Section 2) describes the biomarker performance. The Activities (Section 3) contribute to generating the biomarker. Requirements are placed on the Actors that participate in those activities as necessary to achieve the Claim. Assessment Procedures (Section 4) for evaluating specific requirements are defined as needed. This QIBA Profile (MR-based cartilage compositional biomarkers (T1ρ, T2) ) addresses the application of T1ρ and T2 for the quantification of cartilage composition, which c

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