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Artykuły w czasopismach na temat "Osteoblast"

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Kim, Jung Ha, Kabsun Kim, Inyoung Kim, Semun Seong, Jeong-Tae Koh, and Nacksung Kim. "The ATF3–OPG Axis Contributes to Bone Formation by Regulating the Differentiation of Osteoclasts, Osteoblasts, and Adipocytes." International Journal of Molecular Sciences 23, no. 7 (2022): 3500. http://dx.doi.org/10.3390/ijms23073500.

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Activating transcription factor 3 (ATF3) has been identified as a negative regulator of osteoblast differentiation in in vitro study. However, it was not associated with osteoblast differentiation in in vivo study. To provide an understanding of the discrepancy between the in vivo and in vitro findings regarding the function of ATF3 in osteoblasts, we investigated the unidentified roles of ATF3 in osteoblast biology. ATF3 enhanced osteoprotegerin (OPG) production, not only in osteoblast precursor cells, but also during osteoblast differentiation and osteoblastic adipocyte differentiation. In a
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Giuliani, Nicola, Francesca Morandi, Sara Tagliaferri, et al. "The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients." Blood 110, no. 1 (2007): 334–38. http://dx.doi.org/10.1182/blood-2006-11-059188.

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The proteasome inhibitor bortezomib may increase osteoblast-related markers in multiple myeloma (MM) patients; however, its potential osteoblastic stimulatory effect is not known. In this study, we show that bortezomib significantly induced a stimulatory effect on osteoblast markers in human mesenchymal cells without affecting the number of osteoblast progenitors in bone marrow cultures or the viability of mature osteoblasts. Consistently we found that bortezomib significantly increased the transcription factor Runx2/Cbfa1 activity in human osteoblast progenitors and osteoblasts without affect
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Bauer, Omri, Amnon Sharir, Ayako Kimura, Shay Hantisteanu, Shu Takeda, and Yoram Groner. "Loss of Osteoblast Runx3 Produces Severe Congenital Osteopenia." Molecular and Cellular Biology 35, no. 7 (2015): 1097–109. http://dx.doi.org/10.1128/mcb.01106-14.

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Congenital osteopenia is a bone demineralization condition that is associated with elevated fracture risk in human infants. Here we show thatRunx3, likeRunx2, is expressed in precommitted embryonic osteoblasts and that Runx3-deficient mice develop severe congenital osteopenia. Runx3-deficient osteoblast-specific (Runx3fl/fl/Col1α1-cre), but not chondrocyte-specific (Runx3fl/fl/Col1α2-cre), mice are osteopenic. This demonstrates that an osteoblastic cell-autonomous function of Runx3 is required for proper osteogenesis. Bone histomorphometry revealed that decreased osteoblast numbers and reduced
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Ducy, P., and G. Karsenty. "Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene." Molecular and Cellular Biology 15, no. 4 (1995): 1858–69. http://dx.doi.org/10.1128/mcb.15.4.1858.

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Osteoblasts are cells of mesodermal origin that play a pivotal role during bone growth and mineralization. The mechanisms governing osteoblast-specific gene expression are still unknown. To understand these mechanisms, we analyzed the cis-acting elements of mouse osteocalcin gene 2 (mOG2), the best-characterized osteoblast-specific gene, by DNA transfection experiments in osteoblastic and nonosteoblastic cell lines and by DNA-binding assays. 5' deletion analysis of an mOG2 promoter-luciferase chimeric gene showed that a region located between -147 and -34 contained most if not all of the regul
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Sutton, Amelia L. M., Xiaoxue Zhang, Diane R. Dowd, Yogendra P. Kharode, Barry S. Komm, and Paul N. MacDonald. "Semaphorin 3B Is a 1,25-Dihydroxyvitamin D3-Induced Gene in Osteoblasts that Promotes Osteoclastogenesis and Induces Osteopenia in Mice." Molecular Endocrinology 22, no. 6 (2008): 1370–81. http://dx.doi.org/10.1210/me.2007-0363.

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Abstract The vitamin D endocrine system is important for skeletal homeostasis. 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] impacts bone indirectly by promoting intestinal absorption of calcium and phosphate and directly by acting on osteoblasts and osteoclasts. Despite the direct actions of 1,25(OH)2D3 in bone, relatively little is known of the mechanisms or target genes that are regulated by 1,25(OH)2D3 in skeletal cells. Here, we identify semaphorin 3B (SEMA3B) as a 1,25(OH)2D3-stimulated gene in osteoblastic cells. Northern analysis revealed strong induction of SEMA3B mRNA by 1,25(OH)2D3 in MG-6
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Park, Yu-Seong, Hyun-Woo Kim, Jin-Hyeon Hwang, et al. "Plum-Derived Exosome-like Nanovesicles Induce Differentiation of Osteoblasts and Reduction of Osteoclast Activation." Nutrients 15, no. 9 (2023): 2107. http://dx.doi.org/10.3390/nu15092107.

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Osteoblasts and osteoclasts play crucial roles in bone formation and bone resorption. We found that plum-derived exosome-like nanovesicles (PENVs) suppressed osteoclast activation and modulated osteoblast differentiation. PENVs increased the proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells and osteoblasts from mouse bone marrow cultures. Notably, PENVs elevated the expression of osteoblastic transcription factors and osteoblast differentiation marker proteins in MC3T3-E1 cells. Higher levels of phosphorylated BMP-2, p38, JNK, and smad1 proteins were detected in
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Skillington, Jeremy, Lisa Choy, and Rik Derynck. "Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes." Journal of Cell Biology 159, no. 1 (2002): 135–46. http://dx.doi.org/10.1083/jcb.200204060.

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Mesenchymal cells can differentiate into osteoblasts, adipocytes, myoblasts, or chondroblasts. Whether mesenchymal cells that have initiated differentiation along one lineage can transdifferentiate into another is largely unknown. Using 3T3-F442A preadipocytes, we explored whether extracellular signals could redirect their differentiation from adipocyte into osteoblast. 3T3-F442A cells expressed receptors and Smads required for bone morphogenetic protein (BMP) signaling. BMP-2 increased proliferation and induced the early osteoblast differentiation marker alkaline phosphatase, yet only mildly
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Hernández-Tapia, Laura G., Zdenka Fohlerová, Jan Žídek, et al. "Effects of Cryopreservation on Cell Metabolic Activity and Function of Biofabricated Structures Laden with Osteoblasts." Materials 13, no. 8 (2020): 1966. http://dx.doi.org/10.3390/ma13081966.

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Biofabrication and maturation of bone constructs is a long-term task that requires a high degree of specialization. This specialization falls onto the hierarchy complexity of the bone tissue that limits the transfer of this technology to the clinic. This work studied the effects of the short-term cryopreservation on biofabricated osteoblast-containing structures, with the final aim to make them steadily available in biobanks. The biological responses studied include the osteoblast post-thawing metabolic activity and the recovery of the osteoblastic function of 3D-bioprinted osteoblastic struct
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Kim, Jung Ha, Kabsun Kim, Inyoung Kim, et al. "Bifunctional Role of CrkL during Bone Remodeling." International Journal of Molecular Sciences 22, no. 13 (2021): 7007. http://dx.doi.org/10.3390/ijms22137007.

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Coupled signaling between bone-forming osteoblasts and bone-resorbing osteoclasts is crucial to the maintenance of bone homeostasis. We previously reported that v-crk avian sarcoma virus CT10 oncogene homolog-like (CrkL), which belongs to the Crk family of adaptors, inhibits bone morphogenetic protein 2 (BMP2)-mediated osteoblast differentiation, while enhancing receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated whether CrkL can also regulate the coupling signals between osteoblasts and osteoclasts, facilitating bone h
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Moriishi, Takeshi, Yosuke Kawai, Ryo Fukuyama, et al. "Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis." International Journal of Molecular Sciences 24, no. 24 (2023): 17319. http://dx.doi.org/10.3390/ijms242417319.

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Bcl2l1 (Bcl-XL) belongs to the Bcl-2 family, Bcl2 and Bcl2-XL are major anti-apoptotic proteins, and the apoptosis of osteoblasts is a key event for bone homeostasis. As the functions of Bcl2l1 in osteoblasts and bone homeostasis remain unclear, we generated osteoblast-specific Bcl2l1-deficient (Bcl2l1fl/flCre) mice using 2.3-kb Col1a1 Cre. Trabecular bone volume and the trabecular number were lower in Bcl2l1fl/flCre mice of both sexes than in Bcl2l1fl/fl mice. In bone histomorphometric analysis, osteoclast parameters were increased in Bcl2l1fl/flCre mice, whereas osteoblast parameters and the
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Rozprawy doktorskie na temat "Osteoblast"

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McManus, Lindsay L. "A study of human mesenchymal stem cells, human primary osteoblasts and osteoblast-like cells using Raman spectroscopy." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551188.

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Raman spectroscopy is a vibrational spectroscopy technique that provides a global biochemical signature and has been shown to have utility in the analysis of biological cells for bone tissue engineering applications. Traditionally, sample analysis in this field employs destructive biological methods that require the use of biomarkers, however, Raman has since become an essential tool in various areas of bio-industry and by incorporating the technique into biological laboratories these perturbing methodologies are no longer the only means of analysis. Therefore the focus of this study was to in
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Hempel, Ute, Carolin Preissler, Sarah Vogel, et al. "Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-165309.

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Sulfated glycosaminoglycans (GAG) are components of the bone marrow stem cell niche and to a minor extent of mature bone tissue with important functions in regulating stem cell lineage commitment and differentiation. We anticipated that artificial extracellular matrices (aECM) composed of collagen I and synthetically oversulfated GAG derivatives affect preferentially the differentiation of osteoblast-precursor cells and early osteoblasts. A set of gradually sulfated chondroitin sulfate and hyaluronan derivatives was used for the preparation of aECM. All these matrices were analysed with human
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Hempel, Ute, Carolin Preissler, Sarah Vogel, et al. "Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts." Hindawi, 2014. https://tud.qucosa.de/id/qucosa%3A28669.

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Sulfated glycosaminoglycans (GAG) are components of the bone marrow stem cell niche and to a minor extent of mature bone tissue with important functions in regulating stem cell lineage commitment and differentiation. We anticipated that artificial extracellular matrices (aECM) composed of collagen I and synthetically oversulfated GAG derivatives affect preferentially the differentiation of osteoblast-precursor cells and early osteoblasts. A set of gradually sulfated chondroitin sulfate and hyaluronan derivatives was used for the preparation of aECM. All these matrices were analysed with human
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Duque, Gustavo. "Molecular changes in the aging osteoblast." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19466.

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Aging is the consequence ofan array of phenotypic variations that appear to involve intrinsic or constitutional properties in all cells and systems, including qualitative and quantitative alterations in development, maturational structure and function. The aging process in bone involves a set ofchanges in bone cells differentiation, interaction and premature death. Osteoblasts are the cells most affected during the aging process in bone due to their complex mechanisms ofdifferentiation, their interaction with honnones and growth factors and their progression to apoptosis.
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Townsend, Paul Andrew. "The molecular basis of osteoblast adhesion." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263651.

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Boonphayak, Piyanan. "Substituted hydroxyapatite analysis of osteoblast response." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/substituted-hydroxyapatite-analysis-of-osteoblast-response(71ddb64d-03b9-4825-875e-61d68bd2d3e6).html.

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Ceramics used for medical purposes are known as bioceramics, such as hydroxyaptite (HA), which is one of the most well studied bioceramics because of its similar composition to human bone and also good biocompatibility, is bioactive and has excellent osteoconductivity. In addition many properties of HA can be improved by the addition of specific elements into its structure. The research in this thesis investigates the substitution of some selected elements into the structure of HA and subsequent characterisation in terms of physical, mechanical and biological responses. Si/S-HA and Sr/B/S-HA w
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Li, Bo. "The role of BK channel in cellular proliferation and differentiation in human osteoblast and osteoblast-like cells." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/35876/.

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Both excitable and non-excitable cells possess plasma membrane ion channels and evidence has accumulated over the last 30 or so years that these channels perhaps play key roles in the cell life and death. This Thesis investigated the characteristics and putative functions of one class of potassium channel, the BK channel in osteoblast-like cells and primary osteoblasts from human, rat and mouse. The properties and functions were defined in vitro using a combination of patch-clamp, reverse transcription-polymerase chain reaction (RT-PCR) and functional assays for cell growth and mineralisation.
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Park, Jung Hwa. "The role of surface chemistry and wettability of microtextured titanium surfaces in osteoblast differentiation." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44732.

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Biomaterial surface energy, chemical composition, charge, wettability and roughness all play an important role in determining the degree of the direct bone-to-implant interface, termed osseointegration. Surface chemistry, which is influenced by surface energy, wettability, and composition, is another factor that determines osteoblast phenotype and regulates osteoblast maturation. Increased surface energy is desirable for bone implants due to enhanced interaction between the implant surface and the biological environment. The extent of bone formation in vivo is also increased with increasing wa
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Huesa, Carmen. "Mechanotransduction in cells of the osteoblast lineage." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25468.

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Allen, Matthew Robert. "Mechanisms of impaired osteoblast function during disuse." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1056.

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Prolonged periods of non-weightbearing activity result in a significant loss of bone mass which increases the risk of fracture with the initiation of mechanical loading. The loss of bone mass is partially driven by declines in bone formation yet the mechanisms responsible for this decline are unclear. To investigate the limitations of osteoblasts during disuse, marrow ablation was superimposed on hindlimb unloaded mice. Marrow ablation is a useful model to study osteoblast functionality as new cancellous bone is rapidly formed throughout the marrow of a long bone while hindlimb unloading is
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Książki na temat "Osteoblast"

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Najafova, Zeynab. Epigenetic regulation of osteoblast differentiation. Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017.

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Knight, Susan Mary. A study of osteoblast function in osteoporosis. University of Birmingham, 1994.

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Tarrant, Sarah Fiona. Osteoblast interactions with bone biomaterials 'in vitro'. Universityof Birmingham, 1989.

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Liu, Fina. Molecular and cellular analysis of the osteoblast lineage. University of Toronto, Faculty of Dentistry], 1997.

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Al-Ajmi, Nada Mohammad Zaid. The effect of clinostat rotation on osteoblast behaviour. University of Manchester, 1997.

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Rosenberg, Nahum. Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8.

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Horgan, Fergal G. Osteoblast response to sputter deposited calcium phosphate thin film coatings. The author], 2004.

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Steven, Doty, and United States. National Aeronautics and Space Administration., eds. Effects of hypogravity on osteoblast differentiation: Final report, NCC 2-846. National Aeronautics and Space Administration, 1997.

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Perry, Judith Louise. Production and characterisation of monoclonal antibodies to rat osteoblast-like cells. University of Birmingham, 1989.

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Phillips, John L. Regulation of cytokine production in the rat osteoblast by tansforming growth factor-BETA. s.l.], 1992.

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Części książek na temat "Osteoblast"

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Baum, H. "Osteoblast." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2317-1.

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Baum, H. "Osteoblast." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2317.

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Orriss, Isabel R., Sarah E. B. Taylor, and Timothy R. Arnett. "Rat Osteoblast Cultures." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-415-5_3.

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Dillon, Jane P., Victoria J. Waring-Green, Adam M. Taylor, et al. "Primary Human Osteoblast Cultures." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-415-5_1.

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Marie, Pierre J., and Pierre J. Marie. "Osteoblast Biology and Mechanosensing." In Mechanosensing Biology. Springer Japan, 2011. http://dx.doi.org/10.1007/978-4-431-89757-6_8.

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Bukka, Prasanna, Marc D. McKee, and Andrew C. Karaplis. "Molecular Regulation of Osteoblast Differentiation." In Bone Formation. Springer London, 2004. http://dx.doi.org/10.1007/978-1-4471-3777-1_1.

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Vrahnas, Christina, and Natalie A. Sims. "Basic Aspects of Osteoblast Function." In Osteoporosis. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-69287-6_1.

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Arumugam, Meera Q., Roger A. Brooks, Neil Rushton, and William Bonfield. "Incorporation of Human Osteoblast Cells and Osteoblast-Like Cells into Porous Hydroxyapatite Scaffolds." In Bioceramics 17. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.627.

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Chiba, Mirei, Ryosuke Miyai, and Haruhide Hayashi. "Micro-spatial Environment and Osteoblast Osteogenesis." In Interface Oral Health Science 2011. Springer Japan, 2012. http://dx.doi.org/10.1007/978-4-431-54070-0_23.

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de Gorter, David J. J., and Peter ten Dijke. "Signal Transduction Cascades Controlling Osteoblast Differentiation." In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118453926.ch2.

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Streszczenia konferencji na temat "Osteoblast"

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Ravi, Vilupanur A., Roviden Enriquez, Carlos Beecher, et al. "Stability of Advanced Titanium Alloys in Saline Solution and Characterization of Osteoblast Activation." In CORROSION 2012. NACE International, 2012. https://doi.org/10.5006/c2012-01709.

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Abstract Electrochemical characterization of titanium alloys with different levels of boron was carried out in phosphate buffered saline (PBS) at body temperature and in 0.9 wt% sodium chloride (saline) at room temperature. Two types of cyclic potentiodynamic polarization tests were conducted - one based on ASTM F 2129-08 and the other with a broader voltage scan with higher peak potentials that further distinguished the behavior of the different titanium alloys. Break-down (pitting) potentials for the alloys in the latter test were in the 4.9 – 6.5 V range. The susceptibility of osteoblast ce
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Tuan, Rocky S. "Functional Analysis of Bone-Biomaterial Interface." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2675.

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Abstract Proper function and long-term stability of orthopaedic implants depend on the intimate association between bone cells and the implant biomaterial, a process known as osseointegration. Understanding the processes responsible for the establishment and maintenance of a functional bone-biomaterial interface and how these processes may be enhanced is crucial to the rational design and optimization of prosthetic devices. We have utilized cellular, molecular, and high-resolution imaging approaches to analyze the mechanistic basis of bone-biomaterial interactions. Specifically, we have charac
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Li, K., Y. Xie, M. You, L. Huang, and X. Zheng. "Preparation and In Vitro Evaluation of Plasma Sprayed Cerium Oxide Coatings." In ITSC 2016, edited by A. Agarwal, G. Bolelli, A. Concustell, et al. DVS Media GmbH, 2016. http://dx.doi.org/10.31399/asm.cp.itsc2016p0730.

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Abstract This work investigates the effects of cerium oxide (CeO2) coatings on the response of osteoblasts to H2O2-induced oxidative stress. The results show that the coatings have a protective effect, promoting both osteoblast growth and differentiation. This indicates that the CeO2 coating reduces the production of reactive oxygen species in H2O2-treated osteoblasts. These coatings, with their antioxidant properties, appear quite promising for bone regeneration.
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Cox, Lieke G. E., Corrinus C. van Donkelaar, Bert van Rietbergen, Rik Huiskes, and Keita Ito. "Osteocytes in Bone Can Regulate the Turnover of Adjacent Mineralized Growth Plate Cartilage." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206251.

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It is generally believed that bone remodeling is controlled by osteocytes, which act as mechanosensors and regulate the activity of osteoblast and osteoclast cells [1,2]. Osteocytes seem suitable for this function, since they are the most abundant cell type of bone and they form an extensive network of cellular processes by gap junction connections to each other, lining cells, and osteoblasts [1,3].
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Legoux, J. G., F. Chellat, R. S. Lima, et al. "Development of Osteoblast Colonies on New Bioactive Coatings." In ITSC2006, edited by B. R. Marple, M. M. Hyland, Y. C. Lau, R. S. Lima, and J. Voyer. ASM International, 2006. http://dx.doi.org/10.31399/asm.cp.itsc2006p0059.

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Abstract The aging baby boomer population coupled with an increase in life expectancy is leading to a rising number of active elderly persons in occidental countries. As a result, the orthopedic implant industry is facing numerous challenges such as the need to extend implant life, reduce the incidence of revision surgery and improve implant performance. This paper reports results of an investigation on the bioperformance of newly developed coating-substrate systems. Hydroxyapatite (HA) and nano-titania (nano-TiO2) coatings were produced on Ti-6Al-4V and fiber reinforced polymer composite subs
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Shiraishi, Toshihiko, Kazuhiro Sakata, Shin Morishita, and Ryohei Takeuchi. "Visualization of Actin Fibers in a Living Osteoblast Under Shear Deformation." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39810.

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Bone cells are adaptive to surrounding mechanical conditions. Osteoblasts, one of bone cells, have been reported to be sensible to mechanical stimulation and change the generated bone mass. Activation of the signaling molecules in relation to the initial mechanoreception appears to be mediated though changes in the cytoskeleton. In this study, we propose a method to visualize cytoskeletal actin fibers in a living osteoblast under applied shear deformation and measure the local deformation of actin fibers. Transfection of MC3T3-E1, which is an osteoblast-like cell line, with GFP-actin was perfo
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Zhang, Wenting, Yexin Gu, Qiaoling Sun, et al. "Abstract 344: Downregulation of osteoblastic N-cadherin decreases primary multiple myeloma cell - osteoblast interactions." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-344.

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Genç, Ertürk. "Appliances for Cutting the Sternum, Frontal, Parietal and Occipital Bones." In 2025 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2025. https://doi.org/10.1115/dmd2025-1094.

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Abstract During median sternotomy, the movement of the sternal saw making bone incision is inward-outward. Meanwhile, saw blade pulled outward progresses by rubbing against inner surface of sternum. Inward movement pushes necrotic bone dust into mediastinum. It lacerates periosteum and other soft tissues. Not irrigating bone cutting line with physiological saline causes necrosis of osteoblasts at the edges of line as a result of the tissue heating. Laceration occurs on the inner surface of bone due to outward movement of saw blade. Necrotic products pushed into mediastinum, soft tissue lacerat
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Song, Wang, Yang Yueqin, and Chen Guoqing. "Effect of mechanical stress on formation of osteoblast in vitro — A new way to culture osteoblasts." In 2009 ISECS International Colloquium on Computing, Communication, Control, and Management (CCCM). IEEE, 2009. http://dx.doi.org/10.1109/cccm.2009.5267860.

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Van Dyke, William S., Ozan Akkus, and Eric Nauman. "Murine Osteochondral Stem Cells Express Collagen Type I More Strongly on PDMS Substrates Than on Tissue Culture Plastic." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14272.

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The discovery of the multipotent lineage of mesenchymal stem cells has dawned a new age in tissue engineering, where an autologous cell-seeded scaffold can be implanted into different therapeutic sites. Mesenchymal stem cells have been reported to differentiate into numerous anchorage-dependent cell phenotypes, including neurons, adipocytes, myoblasts, chondrocytes, tenocytes, and osteoblasts. A seminal work detailing that mesenchymal stem cells can be directed towards differentiation of different cell types by substrate stiffness alone [1] has led to numerous studies attempting to understand
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Raporty organizacyjne na temat "Osteoblast"

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มาลัยวิจิตรนนท์, สุจินดา, та วัชราภรณ์ ติยะสัตย์กุลโกวิท. การศึกษาผลและกลไกการรักษาภาวะกระดูกพรุนของพืชสมุนไพรไทยกวาวเครือขาวในหนูแรท : รายงานผลการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.45.

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การวิจัยนี้เพื่อศึกษากลไกการออกฤทธิ์ของสารไฟโตเอสโตรเจนที่สกัดได้จากกวาวเครือขาวต่อกระบวนการสร้างและสลายกระดูก และการออกฤทธิ์ผ่านตัวรับของฮอร์โมนเอสโตรเจนในเซลล์สร้างกระดูก osteoblast ของหนูแรท ในหลอดทดลอง โดยทำการทดลองในเซลล์ 2 ชนิด คือ osteosarcoma cell line UMR-106 และ primary rat osteoblast cells และให้สาร genistein (GEN) ที่ความเข้มข้น 0.1, 10 และ 1000 nmol/L, puerarin (PU) ที่ความเข้มข้น 1, 10 และ 100 ug/mL นาน 48 ชั่วโมง เทียบผลการทดลองที่ได้กับ 17β-Estradiol ที่ความเข้มข้น 10 nmol/L (กลุ่มควบคุมเชิงบวก) และ 0.3% DMSO (กลุ่มควบคุมเชิงลง) พบว่าสารสกัดกวาวเครือขาวและสารไฟโตเอสโตรเจนที่พบใ
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Mercer, Robyn R. Breast Cancer Metastasis to Bone Affects Osteoblast Differentiation. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada426273.

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Mercer, Robyn R., and Andrea M. Mastro. Breast Cancer Metastasis to Bone Affects Osteoblast Differentiation. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada416623.

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Karaplis, Andrew. Osteoblast-Derived PTHRP and Breast Cancer Bone Metastasis. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada625302.

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Navone, Nora M. Osteoblast-Prostate Cancer Cell Interaction in Prostate Cancer Bone. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada391088.

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Paranavitana, Chrysanthi. In Vitro Osteoblast Model for Bone Wound Infections and Antimicrobial Therapy. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada608594.

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Sanders, Jennifer L. Actions of Tamoxifen and Estrogen on Osteoblast Protein Kinase C Expression. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada306529.

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Bussard, Karen M. The Role of Osteoblast-Derived Cytokines in Bone Metastatic Breast Cancer. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada471009.

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Bussard, Karen M. The Role of Osteoblast-Derived Inflammatory Cytokines in Bone Metastatic Breast Cancer. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada485641.

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Wiren, Kristine M., and Karl Jepsen. Enhanced Androgen Signaling with Androgen Receptor Overexpression in the Osteoblast Lineage Controls Skeletal Turnover, Matrix Quality, and Bone Architecture. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada448583.

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