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Rozprawy doktorskie na temat „Osteoblast”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

McManus, Lindsay L. "A study of human mesenchymal stem cells, human primary osteoblasts and osteoblast-like cells using Raman spectroscopy." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551188.

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Raman spectroscopy is a vibrational spectroscopy technique that provides a global biochemical signature and has been shown to have utility in the analysis of biological cells for bone tissue engineering applications. Traditionally, sample analysis in this field employs destructive biological methods that require the use of biomarkers, however, Raman has since become an essential tool in various areas of bio-industry and by incorporating the technique into biological laboratories these perturbing methodologies are no longer the only means of analysis. Therefore the focus of this study was to in

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2

Hempel, Ute, Carolin Preissler, Sarah Vogel, et al. "Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-165309.

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Sulfated glycosaminoglycans (GAG) are components of the bone marrow stem cell niche and to a minor extent of mature bone tissue with important functions in regulating stem cell lineage commitment and differentiation. We anticipated that artificial extracellular matrices (aECM) composed of collagen I and synthetically oversulfated GAG derivatives affect preferentially the differentiation of osteoblast-precursor cells and early osteoblasts. A set of gradually sulfated chondroitin sulfate and hyaluronan derivatives was used for the preparation of aECM. All these matrices were analysed with human

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Hempel, Ute, Carolin Preissler, Sarah Vogel, et al. "Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts." Hindawi, 2014. https://tud.qucosa.de/id/qucosa%3A28669.

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Sulfated glycosaminoglycans (GAG) are components of the bone marrow stem cell niche and to a minor extent of mature bone tissue with important functions in regulating stem cell lineage commitment and differentiation. We anticipated that artificial extracellular matrices (aECM) composed of collagen I and synthetically oversulfated GAG derivatives affect preferentially the differentiation of osteoblast-precursor cells and early osteoblasts. A set of gradually sulfated chondroitin sulfate and hyaluronan derivatives was used for the preparation of aECM. All these matrices were analysed with human

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4

Duque, Gustavo. "Molecular changes in the aging osteoblast." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19466.

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Aging is the consequence ofan array of phenotypic variations that appear to involve intrinsic or constitutional properties in all cells and systems, including qualitative and quantitative alterations in development, maturational structure and function. The aging process in bone involves a set ofchanges in bone cells differentiation, interaction and premature death. Osteoblasts are the cells most affected during the aging process in bone due to their complex mechanisms ofdifferentiation, their interaction with honnones and growth factors and their progression to apoptosis.

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5

Townsend, Paul Andrew. "The molecular basis of osteoblast adhesion." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263651.

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6

Boonphayak, Piyanan. "Substituted hydroxyapatite analysis of osteoblast response." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/substituted-hydroxyapatite-analysis-of-osteoblast-response(71ddb64d-03b9-4825-875e-61d68bd2d3e6).html.

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Ceramics used for medical purposes are known as bioceramics, such as hydroxyaptite (HA), which is one of the most well studied bioceramics because of its similar composition to human bone and also good biocompatibility, is bioactive and has excellent osteoconductivity. In addition many properties of HA can be improved by the addition of specific elements into its structure. The research in this thesis investigates the substitution of some selected elements into the structure of HA and subsequent characterisation in terms of physical, mechanical and biological responses. Si/S-HA and Sr/B/S-HA w

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7

Li, Bo. "The role of BK channel in cellular proliferation and differentiation in human osteoblast and osteoblast-like cells." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/35876/.

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Both excitable and non-excitable cells possess plasma membrane ion channels and evidence has accumulated over the last 30 or so years that these channels perhaps play key roles in the cell life and death. This Thesis investigated the characteristics and putative functions of one class of potassium channel, the BK channel in osteoblast-like cells and primary osteoblasts from human, rat and mouse. The properties and functions were defined in vitro using a combination of patch-clamp, reverse transcription-polymerase chain reaction (RT-PCR) and functional assays for cell growth and mineralisation.

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8

Park, Jung Hwa. "The role of surface chemistry and wettability of microtextured titanium surfaces in osteoblast differentiation." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44732.

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Biomaterial surface energy, chemical composition, charge, wettability and roughness all play an important role in determining the degree of the direct bone-to-implant interface, termed osseointegration. Surface chemistry, which is influenced by surface energy, wettability, and composition, is another factor that determines osteoblast phenotype and regulates osteoblast maturation. Increased surface energy is desirable for bone implants due to enhanced interaction between the implant surface and the biological environment. The extent of bone formation in vivo is also increased with increasing wa

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9

Huesa, Carmen. "Mechanotransduction in cells of the osteoblast lineage." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25468.

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10

Allen, Matthew Robert. "Mechanisms of impaired osteoblast function during disuse." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1056.

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Prolonged periods of non-weightbearing activity result in a significant loss of bone mass which increases the risk of fracture with the initiation of mechanical loading. The loss of bone mass is partially driven by declines in bone formation yet the mechanisms responsible for this decline are unclear. To investigate the limitations of osteoblasts during disuse, marrow ablation was superimposed on hindlimb unloaded mice. Marrow ablation is a useful model to study osteoblast functionality as new cancellous bone is rapidly formed throughout the marrow of a long bone while hindlimb unloading is

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11

Somayajula, Dilip Ayyala. "Biocompatibility of osteoblast cells on titanium implants." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207322725.

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Thesis (M.S.)--Cleveland State University, 2008.<br>Abstract. Title from PDF t.p. (viewed on May 8, 2008). Includes bibliographical references (p. 72-76). Available online via the OhioLINK ETD Center. Also available in print.

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12

Rickard, David J. "Modulation of human osteoblast function by oestradiol." Thesis, University of Bath, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293240.

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13

Ball, Michael David. "The optimisation of hydroxyapatite for osteoblast growth." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312229.

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14

Berger, Christine Elizabeth Marie. "Superoxide anion in osteoclast and osteoblast function." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265210.

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15

Yellowley, Clare Elizabeth. "Electrophysiological characterisation of human osteoblast-like cells." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240717.

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16

Ayyala, Somayajula Dilip. "Biocompatibility of osteoblast cells on titanium implants." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207322725.

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17

Osman, M. "Investigation of molecular regulators in osteoblast differentiation." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009617/.

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Bones provide mechanical support for movement and normal daily functions, which can only be provided when healthy. Bone diseases such as osteoporosis and cancer are a worldwide problem affecting millions of people and causing significant financial impact. This study should indicate possible solutions that might contribute to combatting bone diseases by understanding the expression of bone markers that are known to be expressed differentially at different stages of osteoblastic differentiation. Thus a reliable, easily available and easy to maintain bone cell model was selected using osteosarcom

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18

Bhangu, P. S. "Vesicular 'pre-synaptic' glutamatergic signalling mechanisms in bone." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288814.

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19

Clare, Matthew David. "An investigation into novel mechanisms of osteoblast differentiation." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422569.

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20

McHenry, S. M. "Synergistic interactions between osteoblast cells and endothelial cells." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403243.

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21

Liu, Fina. "Molecular and cellular analysis of the osteoblast lineage." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0008/NQ28291.pdf.

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22

Addison, William. "Molecular Determinants of mineralization in osteoblast cell cultures." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92158.

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Mineralization of the extracellular matrix of bone is a cell-mediated process, which is tightly regulated by a delicate balance between stimulatory and inhibitory molecules. A disruption in the metabolism or levels of these mediating factors results in pathologically hypomineralized or hypermineralized bone. The experimental results presented in this thesis describe the effects of key proteins, peptides and small-molecule ions on an osteoblast cell-culture model of bone mineralization.<br>This study presents evidence that pyrophosphate inhibits mineralization by at least three different mecha

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23

Bensaud, Nabila. "ATP-mediated mineralization of MC3T3-E1 osteoblast cultureS." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117162.

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ABSTRACTExtracellular matrix mineralization is a physiological process where hydroxyapatite is deposited onto collagenous matrix. Mineralization is initiated by an increase in phosphate concentration in the matrix and one major regulator of this process is alkaline phosphatase (TNAP). Absence of TNAP in hypophosphatasia patients and TNAP knockout mouse models significantly decreases matrix mineralization; however some mineral is deposited indicating that additional mechanisms exist to increase phosphate levels. In this study, we have used MC3T3-E1 osteoblast cultures to investigate ATP (adenos

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24

Stewart, E. A. "Tyrosine phosphorylation during osteoblast adhesion to biomaterial surfaces." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493347.

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The number of hip replacement operations performed is currently increasing due to the ageing population and the need for revision surgery after around 15 years. Improving the materials used for hip replacements would decrease the need for revision surgery and have an important economic effect as well as increasing quality of life for patients. To ensure the success and longevity of a bone implant, osteoblast cells must adhere and differentiate on the implant material to form a tight junction with the surface.

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Kelly, Jonathan M. "Osteoblast response to oxygen functionalised plasma polymer surfaces." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246918.

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26

Das-Gupta, Victoria. "Investigating the control of osteoblast nitric oxide production." Thesis, Royal Veterinary College (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412918.

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27

Faibish, Dan. "The actions of resolvin E1 on osteoblast function." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12368.

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Thesis (Ph.D.)--Boston University<br>Resolvins are endogenous anti-inflammatory I pro-resolving lipid mediators derived from omega-3 fatty acids. Resolvin E1 (RvE1) reverses periodontitis and promotes regeneration of alveolar bone in vivo. The goal of this project was to determine the mechanism of RvE1 impact on bone formation. RvE1 significantly enhanced bone formation relative to a vehicle control in a mouse craniotomy model of bone healing. Since RvE1 is reported to act through receptors expressed by cells of the innate immune system, the initial hypothesis tested was that RvE1 actions are

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28

Vörös, Pauline [Verfasser]. "Human osteoblast damage after antiseptic treatment / Pauline Vörös." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1067442197/34.

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29

Al-Ajmi, Nada Muhammad Zayd. "The effect of clinostat rotation on osteoblast behaviour." Thesis, University of Manchester, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.668169.

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30

Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184120.

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BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

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31

Lefebvre, Céline. "Transglutaminase expression and activity in MC3T3-E1 osteoblast cultures." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81353.

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Transglutaminases are enzymes that stabilize extracellular matrices by catalyzing the formation of protease-resistant isopeptide crosslinks between and within their substrate proteins. Two transglutaminase isoforms, tissue transglutaminase (tTG) and factor XIIIa (FXIIIa), are expressed in skeletal tissues. Tissue transglutaminase has been previously localized in bone to osteoblasts, the osteoid layer and the pericellular matrix of osteocytes. Factor XIIIa has been localized to mineralizing chondrocytes, however, its expression in osteoblasts has not been reported yet. In order to unders

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32

Jones, Gemma. "Optimisation and characterisation of osteoblast : osteoclast growth in biomaterials." Thesis, Keele University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505664.

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This investigation aims to utilise the cell-cell communications between osteoblasts and osteoclasts to create a functional tissue engineered construct that is closer to physiological remodelling than current single cell tissue engineered constructs. A ratio of osteoblasts:osteoclasts was optimised as well as a culture medium that supports both cell types. Four different materials, each with excellent properties for tissue engineering including biocompatible and biodegradable, were compared for their ability to support co-cultures. These materials are; silk fibroin, from Bombyx mori (water vapo

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33

Kirmizidis, George. "Osteoblast responsiveness to VEGF : potential applications in tissue engineering." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499329.

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Vascular endothelial growth factor (VEGF) has a multifaceted role in bone remodelling influencing early osteoblastogenesis, promoting angiogenesis to aid bone repair and chemo-attraction of several cell types needed for bone formation. Consequently, VEGF is a good candidate for therapeutic strategies in bone healing and sue engineering. The aim of this study was to characterise osteoblast responsiveness to VEGT during osteogenesis.

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34

Chen, M. "Electrical signalling controls the mobility behaviour of osteoblast cells." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590956.

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Direct current (DC) electric fields (EF) as a guidance cue to influence the migration behaviours of osteoblasts were studied in detail for the first time. Direct current electric fields induced human primary osteoblast cells to migrate towards the anode and the osteoblast -like cell line TE85 migrated towards the cathode. In an EF, TE85 cells re-orientated and the long axis of cells were perpendicular to the vector of the electric field. This reorienting response showed voltage-dependence and could be blocked by the MAPK inhibitor U0126. Both growth factor bFGF and VEGF played an important rol

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35

Fan, Ngo-yin, and 樊傲賢. "The role of protein kinase D in osteoblast differentiation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508488.

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36

Humphrey, Emma Louise. "The control of osteoprotegerin production in osteoblast-like cells." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422110.

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37

Ning, Jian. "The cytoxity of chromium VI in osteoblast derived cells." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366889.

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Jenkins, Alison L. "The thrombin receptor in neutrophils and osteoblast-like cells." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338075.

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39

Nedelcescu, Mihai. "Effects of DP and CRTH2 activation on osteoblast function." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4067.

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Modulation of PGs by inhibition or stimulation is a promising approach for the management of pain and inflammation in patients with rheumatic disease. Based on recent results from our laboratories as well as on the literature, we hypothesise that Prostaglandin D[subscript 2] (PGD[subscript 2]) is an important anabolic agent for osteoblasts. Our results show that the PGD[subscript 2] decreases the osteoblasts proliferation acting probably through the CRTH2 receptor. Surprisingly, when DK-PGD[subscript 2] was used alone or with Naproxen, although the proliferation decreased with the dose, it see

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Fan, Ngo-yin. "The role of protein kinase D in osteoblast differentiation." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508488.

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Weivoda, Megan Moore. "The isoprenoid biosynthesis pathway and regulation of osteoblast differentiation." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1106.

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Statins, drugs commonly used to lower serum cholesterol, have been shown to stimulate osteoblast differentiation and bone formation. By inhibiting HMG-CoA reductase (HMGCR) statins deplete the cellular isoprenoid biosynthetic pathway products farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). Current thought in the field is that statins stimulate bone formation through the depletion of GGPP, since exogenous GGPP prevents the effects of statins on osteoblasts in vitro. We hypothesized that direct inhibition of GGPP synthase (GGPPS) would similarly stimulate osteoblast differe

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Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." PLOS one, 2008. https://tud.qucosa.de/id/qucosa%3A28994.

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BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

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43

Bell, Bryan Frederick. "Mechanisms regulating osteoblast response to surface microtopography and vitamin D." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31711.

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Thesis (Ph.D)--Materials Science and Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Barbara Boyan; Committee Member: Andres Garcia; Committee Member: Anthony Norman; Committee Member: Nael McCarty; Committee Member: Zvi Schwartz. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Wilson, Cameron. "Mediation of Osteoblast Responses to Titanium Roughness by Adsorbed Proteins." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16096/.

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Stable fixation of implants such as artificial teeth depends on the direct apposition of bone to the implanted material. While endosseous implants were traditionally allowed to "osseointegrate" over several months without carrying load, clinical and experimental data show that prostheses with roughened surfaces allow successful integration when subject to earlier loading and more challenging implant sites. However, to design implant surfaces for an optimal biological response requires an understanding of the mechanism by which roughened surfaces promote osseointegration. Research into this me

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Al-Jallad, Hadil. "Role of transglutaminase enzymes in osteoblast differentiation and matrix deposition." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106326.

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Bone formation is an osteoblast-mediated process that is controlled by systemic factors such as hormones, growth factors and local cues that arise from the extracellular matrix (ECM). Bone ECM is elaborated by osteoblasts and therefore they can control their own activity. The ultimate goal of bone matrix formation is to elaborate an extracellular network, consisting mainly of fibronectin and collagen type I, that is capable of mineralizing and forming a strong tissue with appropriate tensile and elastic properties. This thesis describes studies that link transglutaminases (TGs), the protein cr

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Horgan, Fergal G. "Osteoblast response to sputter deposited calcium phosphate thin film coatings." Thesis, University of Ulster, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400963.

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47

Langeveldt, Carmen Ronel. "Alternative insulin mitogenic signaling pathways in immature osteoblast cell lines." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52646.

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Thesis (MSc)--University of Stellenbosch, 2002.<br>ENGLISH ABSTRACT: Insulin is a mitogen for many cells and commonly signals through the classical, mitogenic Raf- MEK-ERK or metabolic PB-kinase pathways. Insulin deficiency or type I diabetes causes severe osteopenia. Obese patients with type II diabetes or insulin resistance, a disease associated with defective insulin signaling pathways and high levels of circulating insulin, have increased or normal bone mineral density. The question of whether hyperinsul inemia preserves bone mass is frequently raised. However, there is still a lot o

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48

Whited, Bryce Matthew. "Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/32699.

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Biodegradable polyesters, such as poly(DL-lactic-co-glycolic acid) (PLGA), have been used to fabricate porous bone scaffolds to support bone tissue development. These scaffolds allow for cell seeding, attachment, growth and extracellular matrix production in vitro and are replaced by new bone tissue when implanted into bone sites in vivo. Hydroxyapatite (HAP) and Æ Ã -tricalcium phosphate (Æ Ã -TCP) ceramics have been incorporated into PLGA bone scaffolds and have been shown to increase their osteoconductivity (support cell attachment). Although HAP, Æ Ã -TCP, and biodegradable polyesters a

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49

Brister, Aaron B. "OASIS AND XBP-1 ACTIVITY IN OSTEOBLAST DIFFERENTIATION AND OSTEOSARCOMA." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196287582.

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Wilson, Cameron John. "Mediation of Osteoblast Responses to Titanium Roughness by Adsorbed Proteins." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16096/1/Cameron_Wilson_Thesis.pdf.

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Stable fixation of implants such as artificial teeth depends on the direct apposition of bone to the implanted material. While endosseous implants were traditionally allowed to "osseointegrate" over several months without carrying load, clinical and experimental data show that prostheses with roughened surfaces allow successful integration when subject to earlier loading and more challenging implant sites. However, to design implant surfaces for an optimal biological response requires an understanding of the mechanism by which roughened surfaces promote osseointegration. Research into this me

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