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Rozprawy doktorskie na temat „Ouabain”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Cellnik, Torsten [Verfasser]. "Defunktionalisierung von Ouabain / Torsten Cellnik." Wuppertal : Universitätsbibliothek Wuppertal, 2019. http://d-nb.info/118842209X/34.

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Magnusson, Emma. "Ouabain Toxicity -Selectivity Towards Renal Cancer Cells." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278574.

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Ouabain and other cardiotonic steroids are known to inhibit Na + ,K + -ATPase (NKA), theion pump responsible for the ionic gradient across the plasma membrane. These steroidsdisplay a selective toxicity towards several tumour cells in comparison to primary humancells, however, the mechanism behind this is not yet understood. Here, we examined theouabain toxicity in renal epithelial cells, proximal tubular cells (PTCs) of different origin. Weinvestigated the relative cytotoxicity in cancer cells (A-498) and papilloma virus-transformedPTCs (HK-2) as well as to primary human PTCs (hPTC) to valida

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3

Harwood, Steven Michael. "Development and application of an immunoassay for ouabain and a study of the nature of endogenous ouabain-like compound." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325540.

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Carneiro, Luciana Teles. "Efeito modulador da ouabaína no sistema imunológico." Universidade Federal da Paraíba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/6866.

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Made available in DSpace on 2015-05-14T13:00:17Z (GMT). No. of bitstreams: 1 parte1.pdf: 1834339 bytes, checksum: 9a90c51efd47d1b0c436c6b761659ab0 (MD5) Previous issue date: 2011-02-21<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Initially known as a cardiotonic steroid capable to inhibit the Na+/K+ATPase, ouabain was identified as an endogenous substance present in human plasma, produced by the adrenal, pituitary and hypothalamus and can interfere with various aspects of immune response. In this study, which aimed to study the modulating effect of ouabain

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5

Tennant, Brian Prichard. "Biosynthesis and physiological characteristics of endogenous ouabain-like substance." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272367.

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Semra, Yemane Kurban. "Endogenous ouabain-like immunoreactive substance (OLIS) : characterisation and physiological studies." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313282.

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Vasconcelos, Danielle Ingrid Bezerra de. "Análise do efeito imunomodulador da ouabaína na inflamação e nocicepção." Universidade Federal da Paraíba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/3640.

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Made available in DSpace on 2015-04-01T14:16:00Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 5574506 bytes, checksum: a2d785f5339e8cb5e573693458ab5abd (MD5) Previous issue date: 2011-09-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Ouabain, known as a cardiotonic glycoside capable of inhibiting the Na+/K+ ATPase, was widely used for heart failure treatment. Identified as an endogenous substance, ouabain is capable of interfering with various physiological functions, including immune system modulation. Besides that, little is known about the involvement o

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8

Gillingwater, Scott David. "Purification and characterisation of ouabain-like compound(s) from biological material." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418070.

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9

Harris, Tanoya L. "Ouabain Regulates Caveolin-1 Vesicle Trafficking by a Src-Dependent Mechanism." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333732028.

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10

Trenti, Annalisa. "Analysis of the molecular mechanisms of the antineoplastic effect of ouabain." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422167.

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Ouabain is a cardiac glycoside whose primary action is inhibition of Na/K ATPase activity, a ubiquitous enzyme responsible for translocating Na and K ions across the cell membrane using ATP as the driving force. It has been demonstrated that the Na/K ATPase also functions as a classical receptor, capable of converting cardiac glycodise binding into activation of various protein kinase cascades (Liu and Xie, 2010). Also, recent studies have shown that cardiac glycosides selectively inhibit cell proliferation and/or induce apoptosis in several cancer cell lines (Schoner and Sheiner-Bobis, 2007).

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11

Veerasingham, Shereeni J. "Salt-induced hypertension, central regulation by ouabain-like compounds and angiotensin II." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58297.pdf.

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12

Ferguson, Alexandra Laura. "Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/465/.

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Preconditioning is the phenomenon whereby tolerance to lethal insults is induced by exposing the tissue to a prior sublethal stimulus. This exists in several forms, such as ischaemic preconditioning, adenosine preconditioning and excitotoxic preconditioning. Adenosine preconditioning is known to be mediated by activation of A1 receptors and ATP-sensitive potassium channels whilst excitotoxic preconditioning mainly involves stimulation of NMDA receptors, nitric oxide and most likely ATP-sensitive potassium channel activation. ATP-sensitive potassium channel openers such as pinacidil and diazoxi

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13

Yuan, Zhaokan. "Signaling Function of Na/K-ATPase in Ouabain-induced Regulation of Intracellular Calcium." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1139325043.

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14

Yeon, Kim. "Cardiotonic Steroids and the Sodium Potassium Pump." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25992.

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Cardiotonic steroids (CTSs), such as digoxin, are used to treat heart failure as they inhibit the sodium potassium pump (NKP). However, sporadic studies report NKP stimulation by a CTS called ouabain. This thesis investigates such reports and explores mechanisms for stimulation. Rabbit cardiomyocytes were isolated and voltage clamped, and the NKP current (Ip) identified. Exposure of myocytes to 5 nM or 10 nM ouabain for ~1-minute significantly increased Ip to 0.69±0.09 pA/pF (N=6) and 0.64±0.05 pA/pF respectively vs. 0.46±0.03 pA/pF in 25 controls. Rostafuroxin, a putative ouabain antagonist,

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15

Chawla, Rohit. "Vascular reactivity of isolated rat mesenteric arterioles in the presence and absence of ouabain." FIU Digital Commons, 2006. http://digitalcommons.fiu.edu/etd/2120.

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The microvasculature plays a significant role in the regulation of blood pressure and regional blood supply. Cardiotonic steroids like the adrenal cortical hormone (ouabain) have been proposed to play a role in some forms of hypertension. The purpose of this study was to determine the effect of different agonists on arteriolar diameter in the presence and absence of ouabain. In Vitro studies on isolated intact rat mesenteric arterioles were performed by administering different concentrations of the vasoconstrictor norepinephrine (NE) and the vasorelaxant acetylcholine (Ach) in the presence and

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16

Cai, Haiping. "Stimulation of apical NHE3 endocytosis by ouabain-activated basolateral Na/K-ATPase Signaling Complex." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1209420160.

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17

Wu, Jian. "Role of Phosphoinositide 3-Kinase a (PI3Ka) in Ouabain-induced Cardiac Signaling and Hypertrophy." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384283312.

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18

Stebal, Cory J. "Isoform Specific Effect of Ischemia/Reperfusion on Cardiac Na,K-ATPase: Protection by Ouabain Preconditioning." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1243946706.

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19

Stebal, Cory. "Isoform specific effect of ischemia/reperfusion on cardiac Na,K-ATPase : protection by ouabain preconditioning." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1243946706.

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Thesis (M.S.)--University of Toledo, 2009.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Science." Title from title page of PDF document. Bibliography: p. 39-48.

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20

Kinoshita, Paula Fernanda. "Sinalização inflamatória e a modulação da expressão de genes induzida pela ação da ouabaína nas isoformas a1, a2 - Na+, K+- ATPase em células da glia." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-24052014-103350/.

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Na,K-ATPase é uma proteína de membrana que tem como função manter o equilíbrio osmótico nas células pela hidrólise de ATP. A ouabaína (OUA) se liga a Na,K-ATPase e é capaz de ativar cascatas de sinalização. As subunidades a da Na,K-ATPase possuem 4 isoformas que são distribuídas de forma diferenciada nos tecidos. As células da glia são importantes na resposta contra lesões no cérebro e também controlam a inflamação. Dados na literatura mostram que a OUA tem efeito protetor em alguns tipos de dano. O objetivo do estudo é avaliar a função da isoforma a2 na cultura de células da glia em respos

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21

Hanke, Jana. "Can Ouabain Protect Transplantation Kidneys fromApoptosis?- Construction of an Experimental Set-Up to StudyStorage-Induced Apoptosis -." Thesis, KTH, Tillämpad fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147357.

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22

Saunders, Robert Peter. "Ouabain stimuliert Signalkaskaden und Zellproliferation in menschlichen Endothelzellen und erhöht die Expression und Freisetzung von Endothelin-1." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974093629.

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23

Kesiry, Riad. "GRP78/BiP is Involved in Ouabain-induced Endocytosis of the Na/K-ATPase in LLC-PK1 Cells." University of Toledo Health Science Campus / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=mco1096302498.

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Loreaux, Elizabeth L. "Role of the Ouabain-Binding Site of Na,K-ATPase in Saline Loading and DOCA-Salt Hypertension." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1213990314.

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25

Tian, Jiang. "Na/K-ATPase, A Signaling Receptor." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1175177603.

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Hopoate-Sitake, Moana Lee. "A Novel Use of Digoxin Immune Fab Fragment in Identification and Isolation of an Endogenous Digitalis-like Factor Found in Preeclampsia." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2599.

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The mechanisms mediating the hypertension of preeclampsia (PE) are unclear. Endogenous digitalis-like factors (EDLFs) are specific sodium pump (SP) inhibitors implicated in essential and experimental hypertension, but they have not been fully explored in the setting of PE. This study uses a digoxin antibody Fab fragment to address the question of whether such factors are present and increased in PE, to investigate a possible treatment of PE, and to isolate and characterize all EDLFs present in PE. Sera and placenta from women with PE did show a significant increase in SP inhibition in comparis

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27

Neto, Hildebrando Candido Ferreira. "Papel dos rins na hipertensão arterial induzida pelo tratamento crônico com ouabaína em ratos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-02022010-105527/.

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A Na+K+-ATPase (NKA) é uma proteína de membrana que participa de mecanismos de transporte nos túbulos renais para a reabsorção de sódio e outros substratos. Sabe-se que a administração de ouabaína (OUA), um inibidor da NKA, induz hipertensão arterial em ratos. No entanto, o papel dos rins nesse modelo de hipertensão não está bem elucidado. Desta forma, o objetivo do presente estudo foi avaliar as possíveis alterações na função renal induzidas pelo tratamento crônico com OUA por 5 ou 20 semanas. Sendo assim, foi observado que o tratamento com OUA promoveu hipertensão de mesma magnitude nos dois

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Pace, Iuri Domingues Della. "Efeito do Triterpeno 3β, 6β, 16β , trihidroxilup-20(29)-eno nas convul-sões induzidas por pentilenotretazol: papel da Na+, K+ ATPase". Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/8993.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Epilepsy is a syndrome characterized by spontaneous recurrent seizures, result of paroxys-mal discharges , excessive or synchronous a neural population . Despite the good prognosis, the high number of patients with epilepsy who have seizures refractory to medication, reflects the lack of a bet-ter understanding of excitotoxic disorders characteristic of this disease. Thus, it becomes important to understand the mechanisms for induction and maintenance of seizures as well, the search for new antiepileptic compounds that may prevent

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Tiruneh, Missale. "Angiotensin II Type 1 Receptor Activation in the Subfornical Organ Mediates Sodium-induced Pressor Responses In Wistar Rats." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23119.

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Na+ sensitive hypertension in Dahl salt sensitive rats (Dahl S) or spontaneously hypertensive rats (SHR) is linked to intrinsic changes in the brain that favour increased Na+ entry into the cerebrospinal fluid (CSF) followed by increases in sympathetic hyperactivity and hypertension (Huang et al 2004). Similar responses are observed in salt resistant and Wistar rats that receive an intracerebroventricular (icv) infusion of Na+ rich artificial cerebrospinal fluid (aCSF) (Huang et al 2001, 2006). Downstream to increased CSF[Na+], a pathway has been described involving mineralocorticoid receptors

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30

Kalushkova, Antonia. "Epigenetic gene regulation in multiple myeloma and mood disorders." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199494.

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Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. Paper I explores the function of the IKKα kinase in regulating gene expression through the nuclear retinoic acid receptor (RAR). We define a set of genes requiring IKKα for their expression and found recruitment of IKKα to the RAR dependent on structural motifs in its protein sequence. This interplay between the NFκB pathway and nuclear receptor regulated transcription

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Orellana, Ana Maria Marques. "Administração intrahipocampal de Ouabaína ativa o NF - kB e a sinalização da proteína WNTem ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-25052012-083840/.

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A enzima Na+, K+-ATPase é uma proteína de membrana altamente conservada em eucariotos, capaz de gerar um gradiente eletroquímico, fundamental para o balanço osmótico das células, o potencial de repouso das membranas e a propriedade excitatória das células musculares e nervosas. Além de seu papel regulatório na homeostasia iônica, desempenha um papel na transdução de sinal e na ativação de transcrição gênica, modulando na presença de ouabaína o crescimento celular, migração e morte celular programada. A Ouabaína (OUA) é um esteróide cardiotônico, produzido no córtex da adrenal e no hipotálamo.

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Stricker, Joshua Lysle. "Protein Participants of Cytosolic Internalization of the Ouabain-bound Na+/K+ATPase Receptor in Human B-3 Lens Epithelial Cells." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1524843508132212.

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Kominato, Rieko. "Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets." Kyoto University, 2008. http://hdl.handle.net/2433/124247.

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Wenceslau, Camilla Ferreira. "Papel da ouabaína endógena sobre o sistema cardiovascular do modelo de hipertensão arterial DOCA-SAL." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-18092012-085246/.

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Tem sido demonstrado que na hipertensão arterial ocorre aumento de ouabaína plasmática, um inibidor da Na+K+-ATPase. Em 1998, Ferrari et al. desenvolveram uma molécula denominada de rostafuroxina, a qual é capaz de antagonizar os efeitos da ouabaína por deslocar a ligação desse glicosídeo com a Na+K+-ATPase. Dentro desse contexto, parece razoável sugerir que um anti-hipertensivo capaz de antagonizar os efeitos da ouabaína possa representar uma nova ferramenta farmacológica para o tratamento da hipertensão arterial. Baseado em tais premissas, o presente estudo avaliou o papel da ouabaína por me

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35

Wenceslau, Camilla Ferreira. "Efeito da administração crônica a longo prazo de ouabaína sobre a pressão arterial e a reatividade vascular de artérias mesentéricas de resistência de rato: possíveis mecanismos envolvidos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-03062008-124025/.

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A ouabaína (OUA) promoveu hipertensão arterial (HA) após 5, 10 e 20 semanas de tratamento e modificou a função vascular de artérias mesentéricas de resistência (AMR). O tratamento por 5 semanas com OUA aumentou o óxido nítrico (NO) e a expressão protéica da isoforma neuronal de óxido nítrico (nNOS), ao passo que diminuiu os prostanóides vasoconstritores. Além disso, reduziu a expressão protéica da Cu-Zn superóxido dismutase (SOD) e aumentou a atividade funcional da Na+K+-ATPase. Já o tratamento por 10 semanas com OUA aumentou NO e prostanóides vasodilatadores, enquanto diminuiu a expressão pro

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36

Gabor, Alexander. "Role of Angiotensin II, Glutamate, Nitric Oxide and an Aldosterone-ouabain Pathway in the PVN in Salt-induced Pressor Responses in Rats." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22900.

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High salt intake contributes to the development of hypertension in salt-sensitive humans and animals and the mechanistic causes are poorly understood. In Dahl salt-sensitive (S) but not salt-resistant (R) rats, high salt diet increases cerebrospinal fluid (CSF) [Na+] and activates an aldosterone-mineralocorticoid receptor-epithelial sodium channel-endogenous ouabain (MR-ENaC-EO) neuromodulatory pathway in the brain that enhances the activity of sympatho-excitatory angiotensinergic and glutamatergic pathways, leading to an increase in sympathetic nerve activity (SNA) and blood pressure (BP). We

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Silva, Juliane Santos de França da. "Efeito anti-inflamatório de ouabaína em modelo murino de lesão pulmonar aguda induzida por LPS." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/9076.

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Submitted by Maike Costa (maiksebas@gmail.com) on 2017-07-07T15:09:57Z No. of bitstreams: 1 arquivototal.pdf: 1854233 bytes, checksum: 535d273c615cebce265419e27f74439a (MD5)<br>Made available in DSpace on 2017-07-07T15:09:57Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1854233 bytes, checksum: 535d273c615cebce265419e27f74439a (MD5) Previous issue date: 2016-10-17<br>Ouabain is a cardiotonic steroid initially described as a substance of plant origin. In 1991, the endogenous production of higher mammals was identified and since then their physiological actions have been studied. Work of

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Banerjee, Moumita. "A Model for Domain-Specific Regulation of Src kinase by alpha-1 subunit of Na/K-ATPase." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1385040354.

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39

Boström, Caroline. "Investigation on Cell-Cell Junctions by Inhibition of Na,K-ATPase Activity." Thesis, KTH, Tillämpad fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298360.

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This thesis report investigates the effect on cellcell junction proteins when the Na,K-ATPase (NKA) is inhibited. The main goal is to develop an understanding of how the NKA activity regulates the cell junction proteins. The investigated proteins are the adherens junction protein ECadherin, and the tight junction proteins Occludin and Claudin7.The NKA is inhibited by introducing the cardiotonic steroid Ouabain to the cells. The treatment is tested for different time lapse and different concentrations. The results show that all proteins are down regulated when treated with high concentrations (

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40

Uhlén, Per. "Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-188-8.

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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the images. The regulation of the dist

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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Doctor of Philosophy (Medicine)<br>Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the

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43

Batrel, Charlène. "Nouvelle méthode d'exploration fonctionnelle du nerf auditif." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON13520/document.

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Contexte: La réponse synchrone des fibres auditives, évaluée à partir de l'onde I des potentiels d'action évoqués auditifs (PEA), ou à partir du potentiel d'action composite (PAC) du nerf auditif, est l'élément clé du dépistage des neuropathies auditives. De récentes études ont toutefois montré que le seuil et l'amplitude de cette réponse pouvaient être absolument normaux malgré une perte importante de fibres du nerf auditif. Dans ce travail de thèse, nous proposons une nouvelle méthode d'exploration fonctionnelle, potentiellement applicable à l'homme, rendant mieux compte du nombre et de l'in

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Lal, Mark. "Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-583-2/.

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Li, Juan. "Na, K-ATPase as a signaling transducer /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-453-2/.

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Rindler, Tara N. "Physiological Role of the α₂-Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function". University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353343442.

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Tang, Yong. "Impact de la perte des neurones cochléaires sur la fonction auditive." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T022/document.

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La surdité est l'un des déficits sensoriels les plus fréquents dans nos sociétés industrialisées. Parmi les pathologies de l'audition, les surdités de perception ou neurosensorielles sont les plus répandues. Les surdités de perception sont dues à un dysfonctionnement de la cochlée impliquant l'homéostasie ionique, la perte des cellules sensorielles et des neurones ganglionnaires. Alors qu'une altération de l'homéostasie ou que la perte de cellules sensorielles entraine immanquablement la survenue d'une surdité, l'impact de la perte de neurones ganglionnaires est mal connu.L'objet de cette thès

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Weitkamp, Christine. "Warum zeigen die Herzglykoside Ouabain und Digoxin unterschiedliche Kreislaufwirkung? Charakterisierung eines mutmasslichen Herzglykosid-Bindungsproteins im Serum und Analyse der Wirkung beider Steroide auf die Endothelin-1- und NO-Freisetzung aus arteriellen Endothelzellen /." Wettenberg : VVB Laufersweiler, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976405792.

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Duan, Qiming. "Cardiac Na/K-ATPase in Ischemia-Reperfusion Injury and Cardioprotection." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1388151402.

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Hao, Jingping. "The electrical properties of Bufo marinus Na⁺, K⁺-ATPase." Ohio : Ohio University, 2009. http://www.ohiolink.edu/etd/view.cgi?ohiou1258151062.

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