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Rozprawy doktorskie na temat „Ovarian metastasis”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Park, Se Hyung. "Estrogen in ovarian cancer cell metastasis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1287.

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Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of migration and invasion by temporal phenotypical and genotypical changes termed epithelial-mesenchymal transition (EMT). Considerable evidence implicates a mitogenic action of estrogen in early ovarian carcinogenesis. In contrast, its influence in the metasta

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Leber, Thomas Matthias. "Regulation of MMP-9 in human ovarian cancer." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298185.

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Huisken-Hill, Alyse Lynn. "Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer." CSUSB ScholarWorks, 2016. https://scholarworks.lib.csusb.edu/etd/355.

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Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian Carcinoma (HGSOC) is the most common type of ovarian cancer and causes 90% of ovarian cancer deaths. 80% of patients have reoccurrence within five years and only 15-30% of patients with recurrent metastatic ovarian cancer respond to current therapies, chemotherapy and surgery. One reason for the high reoccurre

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Davidowitz, Rachel Alexis. "Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10719.

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Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this initial step of ovarian cancer metastasis to investigate the mechanisms of invasion. Pre-clustered ovarian cancer multicellular spheroids are incubated with GFP-expressing mesothelial monolayers and the extent of mesothelial invasion is monitored by time-lapse video microscopy.

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Gardner, M. J. "Adhesion molecules in the interactions of ovarian tumour cells and mesothelial cells." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336754.

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Cheung, Wai-ting. "Role of gonadotropin-releasing hormone of metastatic potential of ovarian cancer cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41634184.

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Cohen, Courtney Alicia. "The Omental Fat Band as an Immunomodulatory Microenvironment for Ovarian Cancer." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50968.

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Cancer research is evolving. Historically concerned with the mechanisms by which malignant cells circumvent cell death signaling and maintain unchecked proliferation, focus has shifted to the complex interactions between the tumor cell and the surrounding microenvironment. Ovarian cancer has one of the highest incidence-to-death ratios of all cancers, and is typically asymptomatic until the later stages, often resulting in metastasis prior to discovery. Naturally occurring phenotypes like lactation and child-bearing (parity) reduce ovarian cancer incidence, but the mechanisms are not understoo

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8

Winiarski, Boleslaw Karol. "Cross talk between ovarian cancer cells and microvascular omental endothelial cells : potential role in metastasis of ovarian cancer to the omentum." Thesis, Exeter and Plymouth Peninsula Medical School, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541700.

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9

Everitt, Gemma Louise Ann. "The inflammatory infiltrate of high-grade serous carcinoma omental metastasis." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8038.

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The aim of this thesis is to investigate the role of inflammatory infiltrates and chemokines in metastasis of high-grade serous ovarian cancer, HGSC, to the omentum using human tissue biopsies and a 3- dimensional (3D) cell culture model. In ten patients with metastatic HGSC, omental tumour deposits contained a prominent leukocyte infiltrate of CD3+ T cells (9% of total cells) and CD68+ macrophages (11% of total cells). The presence of CD68+ macrophages showed a significant positive correlation with tumour cell proliferation analysed by Ki67 expression. Four ovarian cancer cell lines were co-c

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10

Pranjol, Md Zahidul Islam. "Regulation of angiogenic processes in omental endothelial cells during metastasis of epithelial ovarian cancer." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/29914.

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Epithelial ovarian cancer frequently metastasizes to the omentum, a process that requires pro-angiogenic activation of local microvascular endothelial cells (ECs) by tumour-secreted factors. We have previously shown that ovarian cancer cells secrete factors, other than vascular endothelial growth factor (VEGF), with possible roles in metastatic angiogenesis including the lysosomal proteases cathepsin L (CathL) and cathepsin D (CathD), and insulin-like growth factor binding protein 7 (IGFBP7). However, the mechanisms by which these factors may contribute to omental endothelial angiogenic change

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11

Cheung, Wai-ting, and 張慧婷. "Role of gonadotropin-releasing hormone of metastatic potential of ovarian cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41634184.

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12

Flate, Elizabeth L. "THE EFFECT OF EXTRACELLULAR MATRIX COMPONENTS ON MOTILITY AND CHEMOSENSITIVITY OF SELECT OVARIAN CANCER CELL LINES." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353954902.

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13

Shah, Hetal. "Assessment of invasive activities of ovarian cancer cells in vitro." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001126.

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14

McKenzie, Andrew J. "Mechanoregulation of leading edge PKA activity during ovarian cancer cell migration." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/273.

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Ovarian cancer is the deadliest of all the gynecologic cancers and is known for its clinically occult and asymptomatic dissemination. Most ovarian malignancies are diagnosed in the late stages of the disease and the high rate of morbidity is thought to be due, in part, to the highly metastatic nature of ovarian carcinomas. Cancer metastasis relies on the ability of cells to migrate away from primary tumors and invade into target tissues. Though the processes are distinct, cancer cell invasion relies on the underlying migration machinery to invade target tissues. Cell migration requires the coo

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15

Haug, Stefan Peter Gustav [Verfasser], and Robert [Forscher] Zeiser. "Die Rolle von Metadherin bei der Metastasierung des Ovarialkarzinoms = The role of Metadherin in ovarian cancer metastasis." Freiburg : Universität, 2015. http://d-nb.info/1118853091/34.

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Pinto, Paola Bertolotti Cardoso 1976. "Carcinomas mucinosos no ovário : caracterização macroscópica, histológica e imunoistoquímica para o diferencial entre tumores primários e metastáticos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312824.

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Orientadores: Liliana Aparecida Lucci De Angelo Andrade, Sophie Francoise Mauricette Derchain<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T12:06:20Z (GMT). No. of bitstreams: 1 Pinto_PaolaBertolottiCardoso_D.pdf: 22982855 bytes, checksum: ca4a4e679f0037c1494bf2866a333968 (MD5) Previous issue date: 2013<br>Resumo: Os carcinomas mucinosos do ovário são raros e representam apenas 3% dos carcinomas. Frente a este diagnóstico, é preciso descartar a possibilidade de metástase para o ovário, principalmente de neopla

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17

Xu, Wenwei. "Investigation of stiffness as a biomarker in ovarian cancer cells." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50381.

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In this dissertation, we developed cell stiffness as a biomarker in ovarian cancer for the purpose of grading metastatic potential. By measuring single cell stiffness with atomic force microscopy and quantifying in vitro invasiveness of healthy and cancerous ovarian cells, we demonstrated that cancerous ovarian cells have reduced stiffness compared to the healthy ones and invasive ovarian cancer cells are more deformable than noninvasive ovarian cancer cells. The difference in cell stiffness between two genetically similar cell lines was attributed to actin-mediated cytoskeletal remodeling as

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18

Pak, Ho, and 白浩. "Transcriptional regulation of metastasis-related genes matrix metalloproteinase-9 and Snail by p70 S6 kinase in ovarian cancercells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45902689.

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19

Amawi, Haneen. "Optimization of Synthetic Flavonolignans to Target Embryonic Signaling in Metastatic Ovarian and Colon Cancer." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1510514631544003.

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20

Touboul, Cyril. "Influence du stroma et des cellules souches mésenchymateuses sur la dissémination et la résistance au traitement des carcinomes ovariens épithéliaux." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00907889.

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Le cancer épithélial de l'ovaire (EOC) a la particularité d'être diagnostiqué à un stade avancé chez 75% des patientes et de récidiver dans un grand nombre de cas malgré une bonne réponse initiale à la chimiothérapie, expliquant ainsi son pronostic sombre. Le rôle du microenvironnement tumoral semble être de premier plan dans le développement et la survie des cellules cancéreuses mais il existe encore peu de données concernant les cellules mésenchymateuses souches (MSC). Dans ce travail nous avons donc cherché à déterminer les mécanismes moléculaires entre les MSC et les cellules tumorales ova

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21

Almeida, Bernardo Gomes de Lacerda. "Linfangiogênese e seu papel no diagnóstico diferencial entre tumores mucinosos primários e secundários do ovário." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-20102014-121310/.

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Metástases em ovário geralmente se apresentam como o primeiro sinal de doença, com o tumor primário não sendo imediatamente reconhecido. A diferenciação mucinosa é o fenótipo mais comum entre essas metástases. Em algumas situações, quando essa apresentação está associada a carcinomas metastáticos capazes de simular tumores ovarianos primários, essa configuração pode levar até mesmo patologistas experientes a diagnosticar incorretamente um depósito secundário como uma neoplasia primária. A maioria dos casos problemáticos pode ser resolvida correlacionando-se os dados clínicos, as característica

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22

Sengupta, Sameer. "The influence of BRCA1's ubiquitin ligase activity on cell motility." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b14af4ae-1f95-4d0c-85a8-faaf4fa950c4.

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Breast cancer type 1 susceptibility protein (BRCA1) has been established as an important tumour suppressor protein and its loss of function is associated with hereditary breast and ovarian cancer. An emerging body of work suggests that BRCA1 is involved in sporadic cases of breast and ovarian cancers and may also have a role in other cancers, indicating a more global role in tumourigenesis. BRCA1-mutated cancers can be early-onset and are characterised by being highly aggressive with a propensity to metastasize, thus from a clinical perspective there is a requirement to understand the molecula

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23

Kwok, Mon-sze. "Study of metastatic suppressing genes on ovarian carcinomas /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36586328.

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Kwok, Mon-sze, and 郭夢思. "Study of metastatic suppressing genes on ovarian carcinomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010729.

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25

Malek, Joël. "Genetic alterations of the metastatic lesions in ovarian carcinoma." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T109.

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Le cancer de l’ovaire est le cancer gynécologique avec la plus grande mortalité due à un diagnostique tardif au stade de maladie extensive péritonéale. Malgré les progrès de la chirurgie radicale et de la chimiothérapie les récurrences abdominales demeurent la cause la plus fréquente de mortalité. Il existe peu d’études de la maladie métastatique péritonéale. Notre hypothèse de travail est que les différences entre la maladie métastatique et la tumeur primaire sont primordiales dans la survenue d’une maladie résiduelle ou récurrente. Nous avons utilisé une approche exhaustive comprenant des ét

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26

Kennedy, Brian Michael Kennedy. "Leveraging Multimodal Tumor mRNA Expression Data from Colon Cancer: Prospective Observational Studies for Hypothesis Generating and Predictive Modeling." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1498742562364379.

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Aalders, Maurice Christian Gerard. "Aspects of photodetection in cervical and ovarian neoplasia." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/57885.

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Shea, Amanda Ann. "The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/54562.

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Obesity is a major global health concern due to its steadily increasing rates and significant contribution to numerous diseases, including cancer. Ovarian cancer specifically, is associated with a 30% increased risk with obesity, although the mechanisms for this are unknown. Waist-to-hip ratio has been especially associated with ovarian cancer, suggesting that visceral fat may be the greatest contributor. Here, we investigated individual visceral fat depots as independent contributors to cancer progression, specifically focusing on adipose tissue-derived stem and progenitor cells, which have p

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Shea, Amanda A. "The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54562.

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Obesity is a major global health concern due to its steadily increasing rates and significant contribution to numerous diseases, including cancer. Ovarian cancer specifically, is associated with a 30% increased risk with obesity, although the mechanisms for this are unknown. Waist-to-hip ratio has been especially associated with ovarian cancer, suggesting that visceral fat may be the greatest contributor. Here, we investigated individual visceral fat depots as independent contributors to cancer progression, specifically focusing on adipose tissue-derived stem and progenitor cells, which have p

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Hyler, Alexandra Rochelle. "Evaluating the Effects of Fluid Shear Stress on Ovarian Cancer Progression and Metastatic Potential." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/94135.

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Most women die of ovarian metastasis rather than the effects of the primary tumor. However, little is known about the factors that support the survival and secondary outgrowth of exfoliated ovarian cancer cells. In addition to genetic and molecular factors, the unique environment of the peritoneal cavity exposes ovarian cells to biophysical forces, particularly fluid shear stress (FSS). These biomechanical forces, only recently identified as a hallmark of cancer, induce rapid signaling events in attached and aggregated cells, a process termed mechanotransduction. The cellular responses to thes

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31

Yamamura, Shogo. "The activated TGF-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer." Kyoto University, 2012. http://hdl.handle.net/2433/152494.

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GAMBELLI, ALICE. "ITGA6 is a key molecule in driving metastatization of platinum resistant epithelial ovarian cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3014977.

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Epithelial ovarian cancer (EOC) is a relatively rare disease usually diagnosed in advanced stages (III and IV stage). Standard of care includes radical surgery followed by platinum-based chemotherapy. Yet, 15% to 30% of EOC patients have a primary platinum-resistant or refractory disease and more than 70% of originally platinum-sensitive advanced stages patients will develop a resistant disease disseminated in the abdomen and pelvis. For these reasons, the net five-year survival by stage is only of 26% and 13% for stage III and IV, respectively. The resistance to chemotherapy is one of the maj

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Kyriazi, Stavroula. "The role of diffusion-weighted magnetic resonance imaging in evaluating chemotherapeutic response of metastatic ovarian cancer." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543776.

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Jückstock, Julia [Verfasser]. "Beeinflussung des Metastasierungspotentials beim Ovarial- und Mammakarzinom durch das Metastasen-assoziierte Gen MTA1 und das Leucin zipper downregulated in cancer 1-Gen (LDOC1) / Julia Jückstock." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1147681422/34.

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Matha, Kévin. "Développement de nanovecteurs innovants destinés au traitement de la leishmaniose viscérale. Bioinspired hyaluronic acid and polyarginine nanoparticles for DACHPt delivery Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine: Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer Targeting of immunosuppressive myeloid cells from glioblastoma patients by modulation of size and surface charge of lipid nanocapsules Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking." Thesis, Angers, 2020. http://www.theses.fr/2020ANGE0027.

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La leishmaniose viscérale (VL) est une anthropozoonose causée par un parasite protozoaire unicellulaire appartenant au genre Leishmania. Parmi les 20 espèces de Leishmania pathogènes pour l’Homme, Leishmania donovani et Leishmania infantum sont les agents les plus importants responsables de la VL et sont la cause de problèmes de santé touchant 400 000 personnes par an. La VL est létale si non traitée, elle est responsable de la mort de 30 – 40 000 personnes par an. Et pourtant, l’Organisation mondiale de la santé définit cette maladie comme négligée. Dans le manuscrit présenté, nous proposons

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Huang, Liang-Cheng, and 黃亮澄. "The organ tropism of ovarian cancer metastasis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/09636835813418124445.

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碩士<br>國立臺灣大學<br>分子與細胞生物學研究所<br>102<br>Ovarian cancer is the most lethal gynecologic malignancy, and the majority of deaths occur due to metastatic disease. Many studies have identified the specific pattern of metastasis, termed organ tropism, including ovarian cancer. In this thesis, we used the CB17/lcr-PRkdc scid/Crl mice to show that different ovarian cancer cell lines had different organ tropism. The A1847 line and A2780 line derived from primary ovarian tumors displayed ovary tropism upon intravenous injection. The Skov3 cells derived from the ascites of ovarian adenocarcinoma form me

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Li-WeiKuo and 郭力維. "The microRNA-150 promotes metastasis in ovarian cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/80111919097056483920.

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碩士<br>國立成功大學<br>臨床醫學研究所<br>101<br>Ovarian cancer is the ninth leading cause of global cancer-related deaths. It is associated with high mortality due to high recurrence rates, especially metastatic recurrence. Metastatic recurrence is the main feature of advanced ovarian cancer and a direct cause of death. It is important to identify biomarkers and therapeutic targets for early detection and treatment of metastatic recurrence of ovarian cancer. The focus of our study is on microRNAs (miRNAs), which are small (~22 nt) non-coding RNAs that negatively regulate downstream target genes. They contro

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Lokman, Noor Alia. "Role of annexin A2 in ovarian cancer metastasis." Thesis, 2014. http://hdl.handle.net/2440/85190.

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Ovarian cancer is the most lethal gynaecological cancer. We identified annexin A2 to be modulated in the co-culture of ovarian cancer and peritoneal cells in vitro. Annexin A2, a calcium phospholipid binding protein, has been characterized in many malignancies and mediates various cellular functions such as cell motility, invasion, proliferation, angiogenesis and cell adhesion. Annexin A2 heterotetramer consists of annexin A2 and S100A10 monomers on the cell surface and plays an important role in the plasminogen activator system that enhances cancer cell invasion and metastasis. The aim of thi

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Jiang, Zhe-Yu, and 江哲佑. "Identification of the factors that promote ovarian cancer cell metastasis." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/89939179597039925212.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>104<br>Ovarian cancer is the most lethal gynecologic malignancy. It not only is hard to be diagnosed at the early stages, but also comes along with a high recurrent rate as well as chemoresistance at the advanced stages even after surgical treatment. In order to improve the current treatment of ovarian cancer, I attempted to identify the important factors potentially involved in the progressions of metastasis and angiogenesis. Firstly, I designed an in vivo selection scheme using nude mice to select ovarian cancer cells tending to metastasis and recurrence. A2

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Ween, Miranda Peggy. "The biological role of extracellular matrix in ovarian cancer metastasis." Thesis, 2010. http://hdl.handle.net/2440/65056.

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Ovarian cancer metastasis is characterized by the shedding of malignant cells from the surface of the ovary and their implantation onto the peritoneal surface which lines the abdominal cavity. As the factors promoting this process are poorly understood, we investigated the ovarian cancer–peritoneal interaction by means of in vitro co-culture experiments with ovarian cancer (OVCAR-3, OVCAR-5, and SKOV-3) and peritoneal (LP-9) cells. In this system, we identified by mass spectrometry that levels of transforming growth factor β inducible protein (TGFBIp), periostin, fibronectin, plasminogen activ

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Cao, Liyun. "Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis." Thesis, 2012. http://hdl.handle.net/1805/2817.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal metastasis. TG2 is a multifunctional protein which catalyzes Ca2+-dependent cross-linking of proteins. The purpose of this study was to explore the mechanism by which TG2 is upregulated in OC and its role in OC progression. We demonstrated that transforming growth factor (TGF)-β1 is secreted in the OC milieu and regulates the expression a

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42

Sinha, Devbarna. "A novel, angiogenesis-independent role for pericytes in ovarian cancer progression and metastasis." Phd thesis, 2014. http://hdl.handle.net/1885/150213.

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Cancer-associated fibroblasts (CAFs) are a heterogeneous population of cells known for their pro-tumourigenic effect in the microenvironment of solid tumours. One of their major sources is bone marrow derived mesenchymal stem cells (BM MSCs), a population with a demonstrated ability to infiltrate the site of the tumour and engage in paracrine cross-talk with the tumour cells. However, the role of a locally resident perivascular MSC population, i.e. pericytes, has not been explored in this context. Pericytes are contractile cells located around microvessels and are known for their prominent rol

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43

Chiang, Fan-Ying, and 江芳瑩. "Identification of metastasis-associated proteins in ovarian cancer cell line by proteomics approach." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/57788353967004483192.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>100<br>Ovarian cancer is the most lethal gynecological cancer among women worldwide. The majority of malignant ovarian tumors are epithelial type and metastasis has occurred in most patients at the time of diagnosis. Subsequent recurrence rate is high after complete surgery and chemotherapy. Survival is at about 4 years for patients with advanced ovarian cancer. Based on the morphological criteria, epithelial ovarian cancers (EOC) are classified into four histological subtypes: serous, mucinous, endometrioid and clear cell. The endometrioid carcinoma (EC) subty

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Pei-HungChou and 周沛虹. "Differentiate human ovarian cancer cell line with different metastasis characteristics by cell mechanical properties." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/atwk5w.

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碩士<br>國立成功大學<br>生物醫學工程學系<br>102<br>Cancer cells exist in a mechanically and chemically heterogeneous microenvironment which undergoes dynamic changes throughout neoplastic progression. The cell mechanical properties (CMs) have been shown to differentiate the proliferation and differentiation of cells in different physiology states. The importance of CMs to cancer is appreciated, yet the contributions of specific cytoskeleton to cells undergoing malignant transformation and their physiological significance need be further elucidated. In human metastatic breast, prostate and lung cancer cell lin

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Yeh, Yu-Ming, and 葉育銘. "Functional Role and Clinical Relevance of MicroRNA 138 and 708 in Ovarian Cancer Metastasis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/79703405442433690584.

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博士<br>國立清華大學<br>分子醫學研究所<br>101<br>Metastasis is the major factor affecting patient survival in ovarian cancer. However, its molecular mechanisms remain unclear. The present study used isogenic pairs of low and high invasive ovarian cancer cell lines to demonstrate the downregulation of miRNA-138 and miRNA-708 in the highly invasive cells, and their functioning as an inhibitor of cell migration and invasion. An orthotopic xenograft mouse model further demonstrated that the expression of miRNA-138 inhibited ovarian cancer metastasis to other organs. Results indicated that miRNA-138 directly targ

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Arens, Gubbels Jennifer A. "Cell surface MUC16 : metastasis, immune evasion, and the promise of immunocytokine therapies in epithelial ovarian cancer /." 2009. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Cheng, Hsin-Yi, and 鄭欣怡. "A novel 5,7-Dihydroxy-3’,4’-Diaminoflavone downregulates HER2 expression and represses metastasis-associated properties in HER2-overexpressing ovarian cancer cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/95130131436858776494.

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碩士<br>淡江大學<br>化學學系碩士班<br>101<br>Flavonoids have been studied for their anti-tumor properties, including anti-proliferative, proapoptotic, anti-angiogenic and cell cycle arrest activities in several cancer cells. Her2 is amplified and/or overexpressed in about 30% of ovarian and breast cancers and is associated with metastasis and drug resistance. A series of novel flavones were used to explore their anticancer effects on cancer cells. We found a 5,7-Dihydroxy-3’,4’-Diaminoflavone, Cpd3, with significant anti-tumor activities in HER2-overexpressing cancer cells, including anti-proliferative, an

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Roque, Ricardo João. "A importância da e-caderina na metastização intra-abdominal do cancro do ovário." Master's thesis, 2018. http://hdl.handle.net/10316/82668.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>O carcinoma do ovário continua a ser uma neoplasia com elevadas taxas de mortalidade, apesar de o seu processo de metastização ser quase exclusivamente intra-abdominal. Este deve-se a alterações na dinâmica e interações intercelulares, mediadas por múltiplas moléculas de adesão e integrinas, entre as quais é considerada da maior importância a E-caderina. Durante muitos anos a sobreexpressão desta molécula foi considerada inversamente proporcional à capacidade de invasão do tumor e como sendo dotada de um pa

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Wu, Kuo-Hui, and 吳國暉. "Berberine Inhibits Metastatic Potential of Ovarian Cancer Cells via PI3K/Akt Signaling Pathway." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04107753842688707418.

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碩士<br>淡江大學<br>化學學系碩士班<br>99<br>Berberine, one of the effective anti-cancer components of Coptis Chinensis, is a type of isoquinoline alkaloid. It has been reported various anti-cancer effects in different human cancer cell lines. Other research reported that berberine inhibited migration and invasion via MAPK pathways of human tongue cancer cells. Here, we reported that berberine inhibits cell proliferation, migration, invasion and angiogenesis of human ovarian cancer cell lines. The effects were mediated through inhibiting EGFR and HER2/neu expression and their down-stream signalings such as

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