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Artykuły w czasopismach na temat „P53 apoptotic markers”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

MESSMER, Udo K., and Bernhard BRÜNE. "Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways." Biochemical Journal 319, no. 1 (1996): 299–305. http://dx.doi.org/10.1042/bj3190299.

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Nitric oxide (NO) generation initiates apoptotic cell death in different experimental systems. In RAW 264.7 macrophages the appearance of typical apoptotic markers is linked to inducible NO synthase induction. Mechanistically, accumulation of tumour suppressor p53 precedes apoptotic DNA fragmentation. With the use of S-nitroglutathione (GSNO) we correlated a dose-dependent p53 up-regulation to DNA fragmentation measured after 4 h and 8 h, respectively. Our studies revealed a linear correlation between the potency of five different NO donors with respect to apoptosis induction and p53 accumulat

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Panasyan, Artak U., D. S. Kobyakov, A. M. Avdalyan, et al. "EXPRESSION OF MARKERS OF APOPTOSIS (P53, BCL-2, BAX) AND PROLIFERATION (KI-67, TOPOISOMERASE IIA, ARGYROPHILIC PROTEINS OF NUCLEOLAR ORGANIZER REGIONS) IN HEALTHY PERSONS AND NON-SMALL CELL LUNG CANCER PATIENTS AND THEIR RELATIONSHIP WITH SOME CLINICAL AND MORPHOLOGICAL PARAMETERS." Russian Journal of Oncology 22, no. 3 (2017): 153–57. http://dx.doi.org/10.18821/1028-9984-2017-22-3-153-157.

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Study of markers of apoptosis and proliferation in relation to clinical and morphological parameters in non-small cell cancer (NSCLC) patients and healthy persons. There were investigated 237 surgery samples of NSCLC and 10 cases of normal lung tissues. p53, bcl-2, bax, Ki-67, topoisomerase IIα (ТороIIα) levels were determined by immunohistochemical method. Argyrophilic proteins associated with nucleolar organizer regions (AgNOR) were detected with silver nitrate. In NSCLC expression of p53, bcl-2, Ki-67, TopoIIα, AgNOR increased and expression of bax was lower if compared with the normal tiss

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Pérez-Mora, Salvador, Juan Ocampo-López, María del Consuelo Gómez-García, Sandra Viridiana Salgado-Hernández, Yazmin Montserrat Flores-Martinez, and David Guillermo Pérez-Ishiwara. "Polyphenols from Bacopa procumbens Nanostructured with Gold Nanoparticles Stimulate Hair Growth Through Apoptosis Modulation in C57BL/6 Mice." Pharmaceutics 17, no. 2 (2025): 222. https://doi.org/10.3390/pharmaceutics17020222.

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Background/Objectives: Alopecia is a hair disorder with a significant impact on quality of life, and its incidence has been increasing in recent years. Current therapeutic options are limited and may cause adverse side effects, highlighting the need to develop safer and more effective formulations. Therefore, the objective of this study was to evaluate the effect of a formulation based on the bioactive fraction of Bacopa procumbens (BFNB), conjugated with gold nanoparticles, on hair growth through the modulation of apoptosis in C57BL/6 mice. Methods: The potential biological activities of the

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Nur, Gokhan, Emrah Caylak, Pinar Aksu Kilicle, Safak Sandayuk, and Ozlem Onen Celebi. "Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity." Open Medicine 17, no. 1 (2022): 1788–96. http://dx.doi.org/10.1515/med-2022-0603.

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Abstract Pesticides, which adversely affect the critical metabolic processes of organisms, disrupt the physiological balance by specifically targeting enzymes and may lead to such consequences that may lead to death. It provides benefits in agricultural activities. The p53 protein antagonizes bcl-2, an anti-apoptotic protein character, and induces apoptosis by causing mitochondrial membrane permeability. This study aims to show the effect of acetamiprid, which is an insecticide from the neonicotinoid class, on bcl-2 and p53 immunoreactivity, which has an important place in the apoptotic mechan

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5

Alonso, Roberto, Mónica López-Guerra, Ramanda Upshaw, et al. "Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM." Blood 114, no. 8 (2009): 1563–75. http://dx.doi.org/10.1182/blood-2009-02-207654.

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Abstract Chronic lymphocytic leukemia (CLL) is an incurable disease derived from the monoclonal expansion of CD5+ B lymphocytes. High expression levels of ZAP-70 or CD38 and deletions of 17p13 (TP53) and 11q22-q23 (ATM) are associated with poorer overall survival and shorter time to disease progression. DNA damage and p53 play a pivotal role in apoptosis induction in response to conventional chemotherapy, because deletions of ATM or p53 identify CLL patients with resistance to treatment. Forodesine is a transition-state inhibitor of the purine nucleoside phosphorylase with antileukemic activit

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Aggarwal, Dipanshu, Devi Charan Shetty, Anshi Jain, Nikita Gulati, and Saurabh Juneja. "Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions." Journal of Oral and Maxillofacial Pathology 27, no. 2 (2023): 287–94. http://dx.doi.org/10.4103/jomfp.jomfp_5_23.

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Background: p53 tumour suppressor gene limits unchecked cellular growth in response to DNA damage, by causing G1 arrest and the activation of apoptosis. Inhibitors of apoptosis include survivin which acts by inhibition of caspases. Survivin has a significant role as a cell cycle modulator and is only minimally present in mature tissues. Aberrant expression of p53 and survivin has been evaluated in various carcinomas. Thus, the objective of this research was to elucidate the co-expression of p53 and survivin in tissue samples of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cel

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7

Mihoubi, Wafa, Emna Sahli, Fatma Rezgui, et al. "Whole and Purified Aqueous Extracts of Nigella sativa L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast Saccharomyces cerevisiae." Cells 11, no. 5 (2022): 869. http://dx.doi.org/10.3390/cells11050869.

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Plants are an important source of pharmacologically active compounds. In the present work, we characterize the impact of black cumin (Nigella sativa L.) aqueous extracts on a yeast model of p53-dependent apoptosis. To this end, the Saccharomyces cerevisiae recombinant strain over-expressing p53 was used. The over-expression of p53 triggers the expression of apoptotic markers: the externalization of phosphatidylserine, mitochondrial defect associated with cytochrome-c release and the induction of DNA strand breaks. These different effects were attenuated by Nigella sativa L. aqueous extracts, w

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8

Munda, Mihael. "Molecular tissue markers integrated: A mathematical model approach to evaluating and predicting prostate cancer using molecular tissue markers." Acta Medico-Biotechnica 17, no. 2 (2024): 42–50. https://doi.org/10.18690/actabiomed.279.

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Purpose: The standard criteria available for the diagnosis of prostate cancer often do not sufficiently predict the course or outcome of this common disease. Evaluating molecular tissue markers, especially those that mark apoptosis and proliferation, in an integrated mathematical model, could contribute to a better understanding of the development and pathogenesis of this disease, aid in the selection of adequate therapies, and open new avenues of therapeutic research. Materials and methods: Paraffin-embedded prostatectomy specimens were stained according to an immunohistochemical protocol for

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El-Aal, Amany Ahmed Abd, Naglaa Saad Mahmoud El-Gebaly, Abeer Said Al-Antably, Marwa Adel Hassan, and Marwa Ahmed El-Dardiry. "Post-immunization immunohistochemical expression of Caspase 3 and p53 apoptotic markers in experimental hydatidosis." Revista Brasileira de Parasitologia Veterinária 25, no. 3 (2016): 333–40. http://dx.doi.org/10.1590/s1984-29612016058.

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Abstract The aim of this study was to investigate post-immunization apoptotic changes in experimental hydatidosis, using Caspase 3 and p53 immunohistochemical markers. Two groups of rabbits were immunized with a crude antigen (group 1) or a partially purified antigen (group 2) and were compared to an infected non-immunized control group. More effective immune responses were obtained in group 2 than group 1, signified by fewer and smaller cystic lesions and more severe destructive changes. Normal growth of cysts was attained in the control group, with no expression of apoptotic markers. Signifi

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Erdogan, Mehmet Kadir, and Guleser Ozer. "Synergistic Anticancer Effects of Bleomycin and Hesperidin Combination on A549 Non-Small Cell Lung Cancer Cells: Antiproliferative, Apoptotic, Anti-Angiogenic, and Autophagic Insights." Pharmaceuticals 18, no. 2 (2025): 254. https://doi.org/10.3390/ph18020254.

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Background: This study investigated the combined effects of hesperidin (Hesp), a natural flavonoid, with bleomycin (BL), a commonly used chemotherapy agent, on A549 human lung cancer cells. Methods: Key parameters assessed included cell viability, colony formation, and cell migration, alongside the expression of apoptotic and autophagic markers (p53, p21, Bax, cleaved PARP, and Beclin-1), VEGF levels, and caspase-3 activity. Results: The findings revealed that the Hesp + BL combination significantly amplified antiproliferative, apoptotic, anti-angiogenic, and autophagic effects compared to eit

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11

Zhang, Kexiong, Lihui Wang, Xiaojing Hong, et al. "Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice." Cells 10, no. 11 (2021): 2892. http://dx.doi.org/10.3390/cells10112892.

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Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that naturally occurring ageing is associated with the DNA damage response (DDR) and activation of the p53 signalling pathway. Telomerase deficiency induced by telomerase RNA component (TERC) knockout (KO) accelerates not only replicative senescence but also altered differentiation and apoptosis of the pulmonary alveolar stem c

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12

Litovchenko, A. V., Yu M. Zabrodskaya, D. A. Sitovskaya, L. K. Khuzhakhmetova, V. G. Nezdorovina, and E. D. Bazhanova. "Markers of Neuroinflammation and Apoptosis in the Temporal Lobe of Patients with Drug-Resistant Epilepsy." Journal of Evolutionary Biochemistry and Physiology 57, no. 5 (2021): 1040–49. http://dx.doi.org/10.1134/s0022093021050069.

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Abstract Current antiepileptic strategies aim to normalize the interaction of the excitatory and inhibitory systems, which is ineffective in treating patients with drug-resistant epilepsy. Neuroinflammatory processes in the epileptic focus and its perifocal area can trigger apoptosis and also contribute to the development of drug resistance. The level of pro- and anti-apoptotic proteins (p-NF-kB, TNF-α, p53, FAS, caspase-3, caspase-9) was analyzed in intraoperative biopsies of the temporal lobe gray and white matter in the brain of patients with drug-resistant epilepsy. An increased level of p

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Zeestraten, Eliane C. M., Anne Benard, Marlies S. Reimers, et al. "The Prognostic Value of the Apoptosis Pathway in Colorectal Cancer: A Review of the Literature on Biomarkers Identified by Immunohistochemistry." Biomarkers in Cancer 5 (January 2013): BIC.S11475. http://dx.doi.org/10.4137/bic.s11475.

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Research towards biomarkers that predict patient outcome in colorectal cancer (CRC) is rapidly expanding. However, none of these biomarkers have been recommended by the American Association of Clinical Oncology or the European Group on Tumor Markers. Current staging criteria result in substantial under- and over-treatment of CRC patients. Evasion of apoptosis, a characteristic feature of tumorigenesis, is known to correlate with patient outcome. We reviewed the literature on immunohistochemistry-based studies between 1998 and 2011 describing biomarkers in this pathway in CRC and identified 26

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Najar, Reza, Sayyed Ghaderian, Hosain Vakili, et al. "The role of p53, bax, bcl2, and 8-OHdG in human acute myocardial infarction." Open Life Sciences 5, no. 4 (2010): 439–45. http://dx.doi.org/10.2478/s11535-010-0030-4.

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AbstractApoptosis is implicated in unfavorable remodeling of the left ventricle during acute myocardial infarction (AMI). Both DNA damage and p53 play important roles in regulating apoptosis. Expression patterns of apoptotic regulating genes such as p53, bax, and bcl-2 highlight the importance of inhibiting ventricle remodeling and subsequent injuries. In the present study, serum levels of p53 and 8-hydroxy-2-deoxyguanosine (8-OHdG) as well as p53, bax, and bcl-2 expression were examined after the onset of AMI in Iranian patients. Serum levels of p53 and 8-OHdG were measured by enzyme-linked i

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Pandi, Kaniga, Binoy Cheriyan, Srinithi Manikandan, et al. "6,3'-dimethoxy flavonol: Evidence-based insights into anti-proliferative and apoptotic effect on osteosarcoma cells." Trakya University Journal of Natural Sciences 26, no. 1 (2025): 39–47. https://doi.org/10.23902/trkjnat.1615568.

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Osteosarcoma, a cancer predominantly affecting children and teenagers, has shown limited improvements in long-term survival rates despite advances in treatment, necessitating new therapeutic approaches. Natural compounds, particularly flavonoids, are being investigated for their anti-cancer properties due to their ability to modulate signaling pathways and induce apoptosis in cancer cells. This study evaluates the anti-carcinogenic effects of 6,3'-dimethoxy flavonol on MG-63 osteosarcoma cells, a p53-null model suitable for testing novel therapies, using various assays. Cell viability and prol

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Wang, Jayson, Nabil El-Masry, Ian Talbot, Ian Tomlinson, Malcolm R. Alison, and Mona El-Bahrawy. "Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients." Gastroenterology Research and Practice 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/107534.

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Introduction. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli (APC) gene. The APC protein interacts with beta-catenin, resulting in the activation of the Wnt signalling pathway. This results in alterations in cell proliferation and apoptosis. We investigated the expression of beta-catenin and related proliferation and apoptotic factors in FAP patients, exploring the expression along the adenoma-carcinoma sequence.Methods. The expression of beta-catenin, p53, bcl-2, cyclin-D1, caspase-3, CD10, and Ki-67 proteins was studied by immunohisto

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Neubauer, Katarzyna, Barbara Woźniak-Stolarska, and Małgorzata Krzystek-Korpacka. "Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered Concentrations of Key Apoptosis Players: Preliminary Results." BioMed Research International 2018 (November 1, 2018): 1–10. http://dx.doi.org/10.1155/2018/4961753.

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Notwithstanding uncertain pathogenesis of inflammatory bowel disease (IBD), deregulation of adaptive immunity is paramount for the development of inflammation. Essential role in the resolution of inflammation is played by apoptosis, deregulated in lymphocytes isolated from inflamed intestine. Despite IBD being a systemic disease, little is known about apoptosis of peripheral lymphocytes. The concentrations of Bcl-2, cytochrome c, p53, and caspase-9 were determined (ELISA) in lymphocyte-enriched fractions of peripheral blood mononuclear cells (LE-PBMCs) from 64 individuals (42 with IBD) and rel

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Xiao, Jia, Rui Guo, Man-Lung Fung, et al. "Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/642920.

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Our previous study demonstrated that administration of garlic-derived antioxidant S-allylmercaptocysteine (SAMC) ameliorated hepatic injury in a nonalcoholic fatty liver disease (NAFLD) rat model. Our present study aimed to investigate the mechanism of SAMC on NAFLD-induced hepatic apoptosis and autophagy. Adult female rats were fed with a high-fat diet for 8 weeks to develop NAFLD with or without intraperitoneal injection of 200 mg/kg SAMC for three times per week. During NAFLD development, increased apoptotic cells and caspase-3 activation were observed in the liver. Increased apoptosis was

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Du, Xiliang, Liang Chen, Dan Huang, et al. "Elevated Apoptosis in the Liver of Dairy Cows with Ketosis." Cellular Physiology and Biochemistry 43, no. 2 (2017): 568–78. http://dx.doi.org/10.1159/000480529.

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Background/Aims: Dairy cows with ketosis are characterized by oxidative stress and hepatic damage. The aim of this study was to investigate hepatic oxidative stress and the apoptotic status of ketotic cows, as well as the underlying apoptosis pathway. Methods: The blood aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (GGT) activities and the haptoglobin (HP), serum amyloid A (SAA) and serum apoptotic cytokeratin 18 neo-epitope M30 (CK18 M30) concentrations were determined by commercially available kits and ELISA ki

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Fröjmark, Anne-Sophie, Jitendra Badhai, Jens Schuster, et al. "Combined Disruptions of the Ribosomal Protein s19 and Pim1 Kinase Genes Are Associated with Increased Myeloid/Erythroid Cellularity and Reduced Apoptosis." Blood 112, no. 11 (2008): 3097. http://dx.doi.org/10.1182/blood.v112.11.3097.3097.

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Abstract Diamond Blackfan anemia (DBA) is characterized by reduced proliferation and increased apoptosis of erythroid progenitors. Approximately 25% of patients are heterozygous for mutations in the gene encoding ribosomal protein S19 (RPS19). The molecular mechanisms behind DBA remain unclear and RPS19 was recently shown to interact with PIM1 kinase. To elucidate the phenotypic and cellular effects of this interaction we generated mice strains with the genotypes Rps19 +/− Pim1 +/+; Rps19 +/+ Pim1 −/− and Rps19 +/− Pim1 −/−. We analyzed the mice for peripheral blood and bone marrow parameters

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Méndez-García, LA, M. Martínez-Castillo, N. Villegas-Sepúlveda, L. Orozco, and EJ Córdova. "Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress–induced apoptosis." Human & Experimental Toxicology 38, no. 8 (2019): 951–61. http://dx.doi.org/10.1177/0960327119845035.

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The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a master regulator of a battery of antioxidant and detoxificant genes with cytoprotective function. Since Nrf2 inactivation is necessary for the complete execution of apoptosis in the presence of extensive cellular damage caused by oxidative stress, constant activation of Nrf2 may protect tumoral cells from apoptosis. The tumor suppressor gene p53 has been suggested to participate in apoptosis-related repression of Nrf2. Thus, we studied the inactivation of Nrf2 during oxidant-induced apoptosis in a p53 dysfunctiona

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Rahayu, Kun Mardiwati, Budiningsih Siregar, and Iin Kurnia. "PENILAIAN EKSPRESI PROTEIN MDM2 DAN P53 SEBAGAI PREDIKTOR RESPON RADIOTERAPI PADA KANKER SERVIKS." BIOMA 12, no. 1 (2017): 1. http://dx.doi.org/10.21009/bioma12(1).1.

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Cervical cancer is the second most common malignancy in Indonesia, and most of cases were already in advanced stage where radiotherapy is a tratement to given. Apoptosis is one of the markers for survival assessment of therapeutic response. In animal experiments MDM2 expression in various cell types to act as a survival factor by inhibiting the apoptotic function of p53 that is played by apoptosis can lead to malignant transformation and result in resistance to radiotherapy. Therefore, MDM2 is overexpressed due to alleged damage to p53 can also be used to assess the success of radiotherapy. Th

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Dias, T. R., L. Rato, A. D. Martins, et al. "Insulin Deprivation Decreases Caspase-Dependent Apoptotic Signaling in Cultured Rat Sertoli Cells." ISRN Urology 2013 (October 9, 2013): 1–8. http://dx.doi.org/10.1155/2013/970370.

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Insulin is essential for the regulation of glucose homeostasis. Insulin dysfunction occurs in several pathologies, such as diabetes mellitus, which is associated with fertility problems. Somatic Sertoli cells (SCs) not only metabolize glucose to lactate, which is the central energy source used by developing germ cells, but also determine the germ cell population size. If a deregulation in SCs apoptosis occurs, it will affect germ cells, compromising spermatogenesis. As SCs apoptotic signaling is a hormonally regulated process, we hypothesized that the lack of insulin could lead to alterations

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Rendo, Veronica, Leslie Lupien, Nicholas Khuu, et al. "OMRT-6. Optimizing MDM2 inhibition for the treatment of high-grade glioma." Neuro-Oncology Advances 3, Supplement_2 (2021): ii8. http://dx.doi.org/10.1093/noajnl/vdab070.031.

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Abstract Over 80% of high-grade gliomas have alterations in members of the p53 pathway, a central regulator of cell cycle progression and apoptosis that becomes activated in response to cellular stress and DNA damage. For tumors that retain wild-type p53, pathway deregulation frequently occurs through the amplification of negative regulators of p53, including the E3 ubiquitin ligase MDM2. The p53/MDM2 interaction axis has served as basis for the development of several classes of MDM2 inhibitors, with AMG232 being the most potent molecule currently undergoing clinical evaluation. As the effects

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Buddhan R, Manoharan S, and Muralinaidu R. "Myrtenal averts apoptotic evasion of cancer cells in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2838–47. http://dx.doi.org/10.26452/ijrps.v11i3.2359.

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Apoptotic avoidance is one of the foremost characteristic features of tumour cells. Apoptotic induction in cancer cells could thus help to identify new anticancer agents from the natural products. The present study has taken an effort to investigate the apoptotic efficacy of myrtenal, a monoterpene, in 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinoma in male golden Syrian hamsters. The present study used the potent carcinogen, 7,12- dimethylbenz(a)anthracene, to develop oral tumours in the buccal pouches of the golden Syrian hamsters. Topical application of the above said carcinoge

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Afravi, Nader, Amirali Salehi, Hassan Norinejad, and Hongxiang Huang. "Effect of 8 weeks of Intense Intermittent Exercise with Thyme Extract on the Expression of Apoptosis Indicators Bax and p53 in Liver Tissue and Insulin Resistance in Type 2 Diabetic Rats." International Journal of Sport Studies for Health 7, no. 4 (2024): 77–85. http://dx.doi.org/10.61838/kman.intjssh.7.4.8.

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Objective: The present study aimed to investigate the effect of eight weeks of exhaustive interval training combined with thyme extract supplementation on the expression of apoptosis markers Bax and P53 in liver tissue and insulin resistance in male rats with type 2 diabetes. Methods and Materials: The study population consisted of 36 male Wistar rats. After 20 weeks of a high-fat diet and intraperitoneal injection of 25 mg/kg STZ, the rats developed diabetes. A fasting blood glucose level between 150 to 400 mg/dL indicated type 2 diabetes. The diabetic rats were then divided into four groups:

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Vilchinskaya, Natalia A., Sergey V. Rozhkov, Olga V. Turtikova, Timur M. Mirzoev, and Boris S. Shenkman. "AMPK Phosphorylation Impacts Apoptosis in Differentiating Myoblasts Isolated from Atrophied Rat Soleus Muscle." Cells 12, no. 6 (2023): 920. http://dx.doi.org/10.3390/cells12060920.

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Regrowth of atrophied myofibers depends on muscle satellite cells (SCs) that exist outside the plasma membrane. Muscle atrophy appears to result in reduced number of SCs due to apoptosis. Given reduced AMP-activated protein kinase (AMPK) activity during differentiation of primary myoblasts derived from atrophic muscle, we hypothesized that there may be a potential link between AMPK and susceptibility of differentiating myoblasts to apoptosis. The aim of this study was to estimate the effect of AMPK activation (via AICAR treatment) on apoptosis in differentiating myoblasts derived from atrophie

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Shalimar, DM, Prasenjit Das, Vishnubhatla Sreenivas, Siddhartha Datta Gupta, Subrat K. Panda, and Govind K. Makharia. "Mechanism of Villous Atrophy in Celiac Disease: Role of Apoptosis and Epithelial Regeneration." Archives of Pathology & Laboratory Medicine 137, no. 9 (2013): 1262–69. http://dx.doi.org/10.5858/arpa.2012-0354-oa.

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Context.—The data on status of apoptosis in patients with celiac disease are conflicting. Furthermore, complex interaction between intrinsic and common apoptotic pathways, apoptotic inhibitors, and epithelial cell proliferation is largely unclear for patients with celiac disease. Objectives.—To determine the role of apoptosis and epithelial cell regeneration in celiac disease. Design.—Twenty-five treatment-naïve patients with celiac disease and 6 patients with functional dyspepsia, as controls, were included and duodenal biopsy specimens from all were subjected to immunohistochemistry with mar

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Azmi, Asfar Sohail, Ayad Al-Katib, Amro Aboukameel, et al. "Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma." Blood 118, no. 21 (2011): 598. http://dx.doi.org/10.1182/blood.v118.21.598.598.

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Abstract Abstract 598 Recent evidence demonstrates that Non Hodgkin's Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that codes for the nuclear exporter protein CRM-1 controlling the localization of critical tumor suppressors including p53 family members. For effective apoptosis and cell cycle regulation, p53/p73 nuclear localization and DNA binding are highly critical making CRM-1 an attractive therapeutic target for NHL that carries >90% wild type/functional p53 and only rare mutations in p73. We have identified novel small molecule inhibitors of CRM-1 (KPTs) that bind ir

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Calenic, Bogdan, Kazuhiko Okamura, Ken Yaegaki, Serban Tovaru, Tomoko Tanaka, and Toshio Imai. "Role of p53-mediated apoptotic pathway in oral lichen planus: Relationship among pro-apoptotic, anti-apoptotic, and keratinocytic markers." Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 26, no. 2 (2014): 221–27. http://dx.doi.org/10.1016/j.ajoms.2013.06.009.

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Xin, Jian, and Yitai Shang. "Alternariol alleviates breast carcinoma by inhibiting cellular proliferation correlated with increased apoptotic events in rats." European Journal of Inflammation 20 (January 2022): 1721727X2211394. http://dx.doi.org/10.1177/1721727x221139485.

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The breast cancer is most frequently diagnosed cancer in the women worldwide. Our study investigated the anticancer effect of alternariol, a secondary metabolite originated from endophytic fungi, against DMBA induced breast carcinoma on Wistar rats. The toxicity study investigated the LD50 and the subsequent doses of alternariol for the carcinogenic study. The breast cancer was developed in rats via induction of DMBA (5 mg/kg, i.v.) and the carcinogenic study was continued for 24 weeks. The induction of breast cancer and the chemotherapeutic effect of alternariol were assessed through histopat

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Jaworski, Łukasz, Jan Zabrzyński, Peter J. Millet, et al. "Correlation between the Long Head of the Biceps Microscopic Degeneration and Extent of Apoptotic Process." Journal of Clinical Medicine 13, no. 15 (2024): 4520. http://dx.doi.org/10.3390/jcm13154520.

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Objectives: The purpose of this study was to determine the correlation between microscopic degeneration in the long head of the biceps tendon (LHBT) and the apoptotic process. Methods: This study included 26 consecutive patients who had undergone arthroscopic biceps tenodesis or tenotomy for symptomatic LHBT with or without concomitant rotator cuff tears (RCTs). Histological examination of the specimens under a light microscope was conducted after staining with hematoxylin, eosin, and the Alcian blue. Histopathological changes were assessed using the original Bonar score and the modified Bonar

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Hend Okasha, Marwa Hassan, Tarek Aboushousha та Safia Samir. "Effect of Interferon-Beta (IFN-β) on tumor suppressor and apoptotic markers in hepatocellular carcinoma cell line". International Journal of Research in Pharmaceutical Sciences 10, № 4 (2019): 2936–43. http://dx.doi.org/10.26452/ijrps.v10i4.1574.

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IFN-β (Rebif) is a drug with valuable cancer therapeutic potential as it mediates anti-proliferation and apoptosis induction. Therefore, this study aimed to evaluate the anti-proliferation of IFN-β through assessing gene expression of p53 and caspase-3 in hepatocellular carcinoma cell (HCC) line (HepG2). The 50% inhibition viability concentration (IC50) of IFN-β was calculated by cytotoxicity assay, and it was tested on normal cell line (Vero). After treating HepG2 cells with IFN-β, p53 and caspase-3 expression was analyzed, at time intervals of 2, 4, 6, and 24 hrs, by real-time PCR, histopath

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El-kott, Attalla F., Eman R. ElBealy, Ali S. Alshehri, Ayman E. El-Kenawy, Heba S. Khalifa та Amira M. AlRamlawy. "Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-κB and STAT3". Cancer Biomarkers 31, № 1 (2021): 13–25. http://dx.doi.org/10.3233/cbm-203257.

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BACKGROUND: Protein kinase R (PKR) can suppress various types of solid tumors by inducing cellular oxidative stress and apoptosis. Likewise, Slaidorside, a plant flavonoid, was shown to have anti-tumorigenesis in many solid tumors. OBJECTIVE: This study evaluated anti-tumorigenesis of Salidroside in HT29 colorectal cancer and investigated if the underlying mechanism involves activation of PKR. METHODS: Control or PKR deficient cells were cultured in DMEM media treated with 100 μM Salidroside and cell survival, apoptosis, and other biochemical-related markers were evaluated. RESULTS: Salidrosid

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Dolgikh, O. V., N. V. Zaitseva, D. G. Dianova, A. V. Krivtsov, K. D. Starkova, and E. A. Otavina. "EXPERIMENTAL MODELING OF APOPTOSIS UNDER CONDITIONS OF STABLE STRONTIUM EXPOSURE." Medical Immunology (Russia) 21, no. 1 (2019): 137–40. http://dx.doi.org/10.15789/1563-0625-2019-1-137-140.

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Apoptosis is defined as a highly regulated form of programmed cell death with typical morphological and biochemical features. A variety of factors, including heavy metals, may influence the intensity of programmed cell death. The aim of the work was to simulate apoptosis in an in vitrosystem under the conditions of stable strontium exposure. The children’s population consuming drinking water with high strontium (Sr2+) content (n = 49) was observed. The level of lymphocyte apoptosis was determined with flow cytometry technique, by means of labeled annexin V-FITC conjugate (AnnV-FITC) and propid

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Ward, George, Judit Espana-Agusti, Keisha Hearn, et al. "Abstract 1627: Switching cell fate from senescence to apoptosis by the combination of a p53 corrector with the MDM2 antagonist ASTX295." Cancer Research 85, no. 8_Supplement_1 (2025): 1627. https://doi.org/10.1158/1538-7445.am2025-1627.

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Abstract Background: ASTX295 is a potent MDM2 antagonist designed to have a shorter half-life (t1/2 4-6 hours in plasma), which leads to an improved safety profile (bone-marrow sparing), making it more amenable to combinations compared to other MDM2 antagonists. The recent success of targeting TP53:Y220C mutant cancers with a p53 corrector molecule holds great promise for treatment of all Y220C TP53 mutant cancers. However, for effective therapy, a high level of p53 signalling will be required to overcome the elevated apoptotic thresholds seen in some cancer cells with co-mutations in pro-surv

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Ibrahim, Abeer A., Mohanad M. Kareem, Taghreed H. Al-Noor, et al. "Pt(II)-Thiocarbohydrazone Complex as Cytotoxic Agent and Apoptosis Inducer in Caov-3 and HT-29 Cells through the P53 and Caspase-8 Pathways." Pharmaceuticals 14, no. 6 (2021): 509. http://dx.doi.org/10.3390/ph14060509.

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In this study, a platinum(II) complex ([Pt(H2L)(PPh3)] complex) containing a thiocarbohydrazone as the ligand was tested as an anti-proliferative agent against ovarian adenocarcinoma (Caov-3) and human colorectal adenocarcinoma (HT-29) through MTT assays. Apoptotic markers were tested by the AO/PI double staining assay and DNA fragmentation test. Flow cytometry was conducted to measure cell cycle distribution, while the p53 and caspase-8 pathways were tested via immunofluorescence assay. Results demonstrated that the cytotoxic effect of the Pt(II)-thiocarbohydrazone complexes against Caov-3 an

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Petrovici, Adriana, Stefan-Adrian Strungaru, Mircea Nicoara, Madalina Andreea Robea, Carmen Solcan, and Caterina Faggio. "Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers." Journal of Marine Science and Engineering 8, no. 2 (2020): 73. http://dx.doi.org/10.3390/jmse8020073.

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Deltamethrin is responsible for health and reproduction problems both in mammals and aquatic organisms. In this study, zebrafish adults were exposed for 15 days to 0.25, 0.5, 1, and 2 μg L−1 non-lethal concentrations of deltamethrin, knowing that is used worldwide on agricultural crops. We investigated the chronic effects of deltamethrin on gonads by histopathological examination, immunohistochemistry, and immunofluorescence using biomarkers for apoptosis (anti-p53, anti-H2A.XS139ph antibodies, and TUNEL assay), oxidative stress (anti-Cox4i1 antibody) and proliferation (anti-PCNA antibody). Am

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Saati, Abdullah A. "Naringenin’s Neuroprotective Effect on Diazino-Induced Cerebellar Damage in Male Albino Rats, with Modulation of Acetylcholinesterase." Brain Sciences 15, no. 3 (2025): 242. https://doi.org/10.3390/brainsci15030242.

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Background: Diazinon, a well-known organophosphorus compound, is recognized for its neurotoxic effects, primarily through the inhibition of acetylcholinesterase (AChE) and induction of oxidative stress. Aim: This study evaluates the neuroprotective effects of naringenin, a citrus flavonoid, against diazinon-induced cerebellar damage in male albino rats. Materials and methods: Twenty-four rats were divided into four groups: control, naringenin, diazinon, and diazinon with naringenin. Results: Histological examination revealed altered structures of Purkinje cells in the cerebellum of the diazino

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Zhou, Jianghong, Shuo Zhang, Yin Tao, Jinjin Wang, Huan Chen, and Hong Zhou. "Glutaraldehyde (GLA) Loaded Albumin Nanoparticles Mediated p53 Targeting Cervical Cancer." Science of Advanced Materials 13, no. 8 (2021): 1430–36. http://dx.doi.org/10.1166/sam.2021.4013.

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Nano-albumin-mediated different doses of glutaraldehyde (GLA) were used in cervical cancer nude mice to observe the expression of p53, Bax protein and genes in transplanted tumors and explore the mechanism of GLA on cervical cancer. Cervical cancer Hela cells were cultured. 20 nude BALB/C-nu female mice were selected to establish transplanted tumor models and separated into control group (n = 5) and GLA group (n = 15). Grouping of glutaraldehyde (GLA)-loaded human serum albumin nano-carriers (GLA-HSANC) drugs was done and separated into GLA low-dose (0.06 µmol/mg) and medium-dose (0.12 µmol/mg

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Dena-Beltrán, José Luis, Porfirio Nava-Domínguez, Dulce Palmerín-Carreño, et al. "EGFR and p38MAPK Contribute to the Apoptotic Effect of the Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) in Colon Cancer Cells." Pharmaceuticals 16, no. 2 (2023): 290. http://dx.doi.org/10.3390/ph16020290.

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Previous works showed that a Tepary bean lectin fraction (TBLF) induced apoptosis on colon cancer cells and inhibited early colonic tumorigenesis. One Tepary bean (TB) lectin was expressed in Pichia pastoris (rTBL-1), exhibiting similarities to one native lectin, where its molecular structure and in silico recognition of cancer-type N-glycoconjugates were confirmed. This work aimed to determine whether rTBL-1 retained its bioactive properties and if its apoptotic effect was related to EGFR pathways by studying its cytotoxic effect on colon cancer cells. Similar apoptotic effects of rTBL-1 with

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Iype, Elizabeth Mathew, Lakshmi S, and Rajan Balakrishnan. "Selected molecular markers as indicators of clinical profile, tumor characteristics and treatment outcome in squamous cell carcinoma of the larynx." Journal of Clinical Oncology 37, no. 15_suppl (2019): e17522-e17522. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17522.

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e17522 Background: Laryngeal Squamous cell carcinoma is widely prevalent in India and is the fourth leading cancer in males. The possibility that specific tumour characteristics (demonstrable by immunohistochemistry) may aid the clinician in choosing optimal treatments for a specific tumour, holds great promise. Objectives of the present study were to study the expression of select molecular markers p53, Bcl-2 (Apoptotic markers), EGFR, Ki67, Cyclin D1 (Proliferation markers) and Cox-2 (Inflammatory marker) in LSCC so as to form a hypothesis that a particular group of markers will be useful in

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Silva-Gomez, Jorge Antonio, Marina Galicia-Moreno, Ana Sandoval-Rodriguez та ін. "Hepatocarcinogenesis Prevention by Pirfenidone Is PPARγ Mediated and Involves Modification of Nuclear NF-kB p65/p50 Ratio". International Journal of Molecular Sciences 22, № 21 (2021): 11360. http://dx.doi.org/10.3390/ijms222111360.

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Targeted therapies for regulating processes such as inflammation, apoptosis, and fibrogenesis might modulate human HCC development. Pirfenidone (PFD) has shown anti-fibrotic and anti-inflammatory functions in both clinical and experimental studies. The aim of this study was to evaluate PPARγ expression and localization in samples of primary human tumors and assess PFD-effect in early phases of hepatocarcinogenic process. Human HCC tissue samples were obtained by surgical resection. Experimental hepatocarcinogenesis was induced in male Fischer-344 rats. TGF-β1 and α-SMA expression was evaluated

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George, Blassan P., Naresh K. Rajendran, Nicolette N. Houreld, and Heidi Abrahamse. "Rubus Capped Zinc Oxide Nanoparticles Induce Apoptosis in MCF-7 Breast Cancer Cells." Molecules 27, no. 20 (2022): 6862. http://dx.doi.org/10.3390/molecules27206862.

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Rubus fairholmianus (RF) has widely been used to treat various ailments, including pain, diabetes, and cancer. Zinc oxide nanoparticles (ZnO NPs) have drawn attention in modern healthcare applications. Hence, we designed this study to synthesize zinc oxide (ZnO) nanoparticles using R. fairholmianus root extract to investigate its synergistic cytotoxic effect on MCF-7 cells and explore the possible cell death mechanism. ZnO NPs were synthesized via green synthesis using R. fairholmianus root extract, and the effect on MCF-7 cells was determined by looking at cellular morphology, proliferation,

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Li, Qiufang, Yanzi Yang, Xiaokai Wang, et al. "Alternariol ameliorates lung carcinoma via reprogramming cytokine signaling associated with PI3K/Akt cascade in vitro and in vivo." European Journal of Inflammation 20 (January 2022): 1721727X2211065. http://dx.doi.org/10.1177/1721727x221106505.

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Objectives The lung cancer is most frequently diagnosed cancer incidence worldwide. A large number of populations are heavily affected to this every year with poor prognosis. Methods Our study investigated the anticancer effect of alternariol, a secondary metabolite, on A549 lung cancer cell line and benzo-α-pyrene induced lung carcinoma model on balb/c mice. The cytotoxicity assay, DAPI staining and the flow cytometry was performed to assess the anticancer efficacy of alternariol in A549 lung cancer cell. For in vivo study the toxicity study was performed. The lung cancer was developed in the

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Samarakoon, Sameera R., Meran K. Ediriweera, Chukwumaobim Daniel Uzochukwuwulu Nwokwu та ін. "A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O-α-L-Arabinosyl Oleanolic Acid) Isolated fromSchumacheria castaneifoliaVahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells". BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/9854083.

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Lung cancer is the major cause of cancer death among men. A number of natural compounds have proven to be useful in the treatmet of lung cancer. This study was aimed to determine cytotoxic and apoptotoic effects of a natural compound 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO) isolated fromSchumacheria castaneifoliain non-small-cell lung cancer (NCI-H292) cells. Cytotoxic effects of 3-O-L-AO were determined by Sulforhodamine B (SRB) assay and apoptotic effects were tested by evaluating (a) apoptotsis related morphological changes, (b) caspase 3/7 activity, and (c) expression ofBax, p53, and s

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De León-Ramírez, Yeimy Mar, Leticia Nicolás-Toledo, Eliut Pérez-Sánchez, and Omar Arroyo-Helguera. "Chronic Variable Stress May Induce Apoptosis in the Testis and Epididymal Sperm of Young Male Rats." Biology 14, no. 6 (2025): 690. https://doi.org/10.3390/biology14060690.

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Stressor stimuli induce oxidative stress and functional abnormalities in sperm, which are linked to a reduced sperm quality and male infertility. Furthermore, oxidative stress can trigger cell death. However, the impact of stressor stimulation on testicles and epididymal sperms and apoptosis has not been explored. This study analyzes the expression of extrinsic and intrinsic apoptotic markers in the testicle and epididymis of rats exposed to chronic variable stress (CVS). We used male Wistar rats divided into two groups: the control group was kept undisrupted, and the stress group was stressed

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Nabil, Muhammad, Azman Seeni, Wan Ismahanisa Ismail, Nurhidayah Ab Rahim, and Syarifah Masyitah Habib Dzulkarnain. "Induction of Apoptotic Mechanism by Streblus Asper Root Extract on Cervical Cancer Using in Vitro and in Vivo Models." Biomedical and Pharmacology Journal 12, no. 04 (2019): 1661–73. http://dx.doi.org/10.13005/bpj/1796.

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Cervical cancer has been ranked as the third most common cancer among women worldwide. As an alternative to existing preventive and treatment measures, natural plants have been seen to carry potential therapeutic value against cancers. These include Streblus asper which proved to possess anti-cancer effects on several types of cancer. In the present study, we observed that S.asper is able to induce apoptosis on cervical cancer cells through the regulation of several apoptotic proteins. This analysis was performed using both in vitro and in vivo models. The protein expression was analysed using

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Dincer, Yildiz, Solen Himmetoglu, Serap Yalin, Taner Damci, Hasan Ilkova, and Tulay Akcay. "Serum levels of p53 and cytochrome c in subjects with type 2 diabetes and impaired glucose tolerance." Clinical & Investigative Medicine 32, no. 4 (2009): 266. http://dx.doi.org/10.25011/cim.v32i4.6617.

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Purpose: To examine apoptotic markers in serum of subjects with diabetes and impaired glucose tolerance (IGT). Serum levels of p53 and cytochrome c, regulator molecules for apoptosis, were measured in subjects with type 2 diabetes, subjects with IGT and healthy controls. Methods: Forty one subjects with type 2 diabetes, 27 with IGT and 27 healthy volunteers were included in the study. Serum level of cytochrome c and p53 were measured with competitive ELISA. Results: Serum levels of p53 were lower in the group of subjects with type 2 diabetes (085±0.39 U/ml) than in controls (1.09±0.49 U/ml) (P

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Cieślińska, Magdalena Wiktoria, Izabela Bialuk, Magdalena Dziemidowicz, et al. "The Influence of Interleukin 6 Knockout on Age-Related Degenerative Changes in the Cerebellar Cortex of Mice." Cells 14, no. 7 (2025): 532. https://doi.org/10.3390/cells14070532.

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This study investigates age-related neurodegeneration in the cerebellar cortex, emphasizing the role of IL-6 deficiency in preserving Purkinje cells. We found that apoptosis plays a minimal role in Purkinje cell loss by using 4-month- and 24-month-old wild-type (WT) and IL-6 knockout (IL-6KO) mice. At 24 months, WT mice exhibited severe Purkinje cell degeneration, including atrophic cell bodies, eosinophilic cytoplasm, pyknotic nuclei, mitochondrial disruption, and increased levels of lipofuscin-rich lysosomes. In contrast, IL-6KO mice showed fewer lysosomes, reduced mitochondrial damage, and

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