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Rozprawy doktorskie na temat „Pain sensitization”

Autor: Grafiati

Data publikacji: 25 stycznia 2025

Data aktualizacji: 31 lipca 2025

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1

McCormick, Emma, and Magdalena Sjöwall. "Central sensitization in orofacial pain." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19833.

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Syfte. Att retrospektivt undersöka relationen mellan central sensitisering i det orofacialaområdet och refererad smärta, som kliniskt fynd, samt psykosociala faktorer hos patienter medDC/TMD-muskeldiagnosen myofasciell smärta med refererad smärta (MPR). Studien syftadeäven till att undersöka skillnader gällande psykosociala faktorer mellan patienter somdiagnostiserats med DC/TMD muskeldiagnoserna myofasciell smärta med refererad smärta(MPR), lokal myalgi (LM) och patienter med orofacial smärta eller käkdysfunktion men ejkäkmuskeldiagnos (WMD) som kontrollgrupper.Material och metod. Information

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Seitz, Viola [Verfasser]. "Sensitization and inhibition of pain / Viola Seitz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1209130866/34.

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Schrepf, Andrew David. "Inflammation and central pain sensitization in Interstitial Cystitis/Bladder Pain Syndrome." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1900.

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Central sensitization refers to abnormal pain modulation present which is characterized by non-aversive or mildly aversive stimuli promoting feelings of pain. Many conditions referred to as Functional Somatic Syndromes (FSS)s are characterized by abnormal pain modulation, including pain in areas of the body not thought to be related to the specific FSS with which the patient has been diagnosed. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a diagnosis of exclusion characterized by pelvic pain and urologic symptoms that shares many environmental and psychosocial correlates with FSSs.

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Janke, Elizabeth Amy. "Psychosocial Correlates of Sensitization in Chronic Pain: An Exploratory Analysis." Ohio University / OhioLINK, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1108061243.

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Asiedu, Marina N. "Spinal Sensitization Mechanisms Promoting Pain: Gabaergic Disinhibition and Pkmζ-Mediated Plasticity". Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/232496.

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As a major public health problem affecting more that 76.5 million Americans, chronic pain is one main reason why people seek medical attention. It is a pathological nervous system disorder that persists for months or years. Sensitization of nociceptive neurons in the dorsal horn of the spinal cord is crucial in the development of allodynia and hyperalgesia. The work presented in this thesis will focus on spinal protein kinase M zeta (PKMζ)-mediated plasticity and GABAergic disinhibition as spinal amplification mechanisms that orchestrate persistent changes in the dorsal horn of the spinal cord

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Warwick, Charles A. "The role of complement component C5a in nociceptive sensitization." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5676.

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The complement system is a principal component of innate immunity. Recent studies have underscored the importance of C5a and other complement components in inflammatory and neuropathic pain, although the underlying mechanisms are largely unknown. In particular, it is unclear how the complement system communicates with nociceptors and which ion channels and receptors are involved. Here we demonstrate that inflammatory thermal and mechanical hyperalgesia induced by complete Freund’s adjuvant were accompanied by C5a upregulation and were markedly reduced by C5a receptor (C5aR1) knockout (KO) or t

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Mickle, Aaron David. "Pain sensitization by parathyroid hormone-related peptide via convergent phosphoregulation of TRPV1." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/5970.

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The neurobiological mechanisms underlying chronic pain in bone-metastasized breast and prostate cancer are not well understood although it is hypothesized that factors released in the tumor microenvironment may modulate sensory nociceptive sensory nerve fibers innervating the bone increasing pain sensation. Advanced metastatic breast and prostate cancer cells secrete high levels of parathyroid hormone-related peptide (PTHrP), which plays a critical role in metastasis to bones and subsequent tumor growth. PTHrP can activate parathyroid hormone receptor 1 (PTH1R), which signaling can activate ei

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Öjstedt, Erik, and Simon Pankalla. "Clinical Assessment of Disturbed Central Pain Modulation in Orofacial Pain." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19798.

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Syfte. Studiens syfte var att retrospektivt undersöka vilka kliniska variabler, bedömda under specialistundersökning av orofacial smärta, som kan förutsäga närvaro av en störd central smärtmodulering (DCPM). Material och metod. DC/TMD-data hämtades ur patientjournaler från 86 patienter som undersökts på Orofaciala smärtenheten på Malmö Universitet under perioden september 2012 till och med december 2013. Undersökta variabler omfattade smärtintensitet, smärtutbredning, smärtrelaterad nedsatthet, psykosociala variabler, refererad smärta samt kliniska fynd under somatosensoriska undersökningar. B

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King, Jacqlyn. "Sensorimotor Abnormalities in Chronic Subacromial Pain: The Influence of Sex, Contribution of Pain, and Utility of Using the Contralateral Limb as a Control." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23190.

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Patients with subacromial pain syndrome (SPS) display a number of sensorimotor deficits including alterations in pain processing, poor proprioception, and weakness at the symptomatic limb. The primary purpose of this dissertation was to explore whether the aforementioned deficits: (1) can be quantified by using the non-involved limb as a measure of control, (2) are purely localized to the symptomatic limb or represent a more generalized deficit, (3) are influenced by the presence of subacromial pain, and (4) present similarly in male and female patients. Here, we utilized modern clinical techn

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Bettini, Elizabeth, and Elizabeth Bettini. "Central Sensitization and Associated Factors in Adolescents With Joint Hypermobility and Dysautonomia." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/622947.

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Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a disorder of the autonomic nervous system that has high association with chronic pain syndromes such as fibromyalgia, migraine disorders, and chronic abdominal pain in adolescents with the diagnosis. Many of these disorders are characterized as central sensitization disorders, or pathological pain memory mediated by neural plasticity. Ehlers Danlos Syndrome Type 3 (EDS-3), also called joint hypermobility syndrome (JHS) is a genetic disorder of the connective tissue that causes joint laxity and is also highly associated with ch

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Lascelles, B. Duncan X. "Studies on the development of sensitization to acute surgical pain in the rat and dog." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296598.

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Lemming, Dag. "Experimental Aspects on Chronic Whiplash-Associated Pain." Doctoral thesis, Linköpings universitet, Rehabiliteringsmedicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10693.

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Introduction: Chronic pain after whiplash trauma (chronic WAD) to the neck is still a common clinical problem in terms of pain management, rehabilitation and insurance claims. In contrast to the increased knowledge concerning mechanisms of chronic pain in general, no clinical guidelines exist concerning assessment, pain control and rehabilitation of patients with chronic WAD. Aim: The general aim of this thesis was to use experimental techniques to better understand the complex mechanisms underlying chronic pain after whiplash trauma. The specific aims of papers I and II were mainly to use ana

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Dickinson, Annelise K. "Do you really want to hurt me? ostracism-induced physical pain sensitization in real-life relationships /." Diss., Connect to the thesis, 2009. http://hdl.handle.net/10066/3592.

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Ferguson, Adam Richard. "Neuropathic pain and the inhibition of learning within the spinal cord." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/350.

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Prior work from our laboratory has shown that the spinal cord is capable of supporting a simple form of instrumental (response-outcome) learning. In a typical experiment, animals are given a spinal transection at the second thoracic vertebra, and tested 24 h after surgery. If animals are given shock when their leg is in a resting position (controllable shock), they quickly learn to maintain the leg in a flexed position, thereby minimizing shock exposure. Animals exposed to shock that is independent of leg position (uncontrollable shock) fail to learn. This learning deficit can be induced by as

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Loo, Lipin. "Modulation of TRPV1, nociceptor sensitization , and induction of thermal hyperalgesia by C-type natriuretic peptide." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2571.

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Rheumatoid arthritis (RA) is caused by aberrant attack of the joints by native inflammatory system. This can lead to joint destruction and pain that can be debilitating. Increased angiogenesis and innervation by nociceptive afferent fibers are characteristic features of RA joints, which in addition to the elevated levels of a wide variety of inflammatory mediators, are thought to play an important role in the pathogenesis of chronic inflammatory pain associated with RA. Interestingly, a recent report indicates that C–type

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Bou, Sader Nehme Sarah. "Cortical mechanisms of comorbidity between pain sensitization and attention-deficit/hyperactivity disorder (ADHD) in a mouse model." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0488.

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Le trouble du déficit de l'attention avec ou sans hyperactivité (TDAH) et la douleur chronique sont deux syndromes complexes d’origine multifactorielle. Des études confirment une comorbidité entre ces deux pathologies. Cependant, les mécanismes ne sont toujours pas élucidés. Une hyperactivité des neurones de l’ACC et une dérégulation de la voie ACC-insula postérieure (PI) ont été démontrées dans un modèle de souris TDAH. La neuroinflammation serait impliquée dans cette concomitance. Notre hypothèse suggère que la neuroinflammation déclencherait une amplification de l’activité neuronale dans l’

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Yan, Jin, Ohannes Melemedjian, Theodore Price, and Gregory Dussor. "Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)." BioMed Central, 2012. http://hdl.handle.net/10150/610216.

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BACKGROUND:Migraine headache is one of the most common neurological disorders, but the pathophysiology contributing to migraine is poorly understood. Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, suggesting that this cytokine may facilitate pain signaling from the meninges and contribute to the development of headache.METHODS:Cutaneous allodynia was measured in rats following stimulation of the dura with IL-6 alone or in combination with the MEK inhibitor, U0126. The number of action potentials and latency to the first action potential peak in

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Schäfer, Axel. "Low back related leg pain: development and preliminary validation of a new classification system." Thesis, Curtin University, 2009. http://hdl.handle.net/20.500.11937/235.

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Background summary. Leg pain is a common complaint in relation to low back pain (LBP), present in up to 65% of all patients with LBP. Radiating leg pain is an important predictor for chronicity of LBP and an indicator of the severity of the disorder. Consequently patients with back and leg pain account for a disproportionate amount of the costs of medical care and disability compensation caused by LBP. As many structures in the lower quarter are capable of evoking a similar pattern of pain, the primary pathology causing low back related leg pain is often difficult to differentiate resulting in

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Bräscher, Anne-Kathrin [Verfasser], and Rupert [Akademischer Betreuer] Hölzl. "Cognitive and Behavioral Context of Pain Facilitation: Nocebo Conditioning and Uncontrollability-Induced Sensitization / Anne-Kathrin Bräscher. Betreuer: Rupert Hölzl." Mannheim : Universitätsbibliothek Mannheim, 2014. http://d-nb.info/1053618700/34.

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Shang, Ye. "Mechanisms Regulating Transient Receptor Potential Cation Channel A1 (TRPA1) and Their Roles in Nociception and Nociceptive Sensitization." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1092.

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Nociception is the sensory nervous system that detects harmful stimuli including excessive heat, cold, toxic chemicals, and noxious mechanical stimulations. Transient receptor potential (TRP) channels are a group of evolutionarily conserved ion channels consisting of 4 subunits, each with 6 transmembrane spans, and detect a variety of external and internal nociceptive stimuli. Due to their critical roles in nociception, it is essential to understand the mechanisms that regulate TRP channels and subsequent nociception. Here, I investigated two distinct types of regulation of Drosophila transien

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Lepri, Beatrice. "Efficacia della Pain Neuroscience Education in pazienti con dolore cronico da sensibilizzazione centrale: una revisione sistematica della letteratura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24579/.

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Background: Il dolore muscoloscheletrico (MSK) cronico influisce in termini di disabilità, qualità di vita e costi di gestione a livello mondiale; è conseguenza di più fattori (biologici, psicologici e sociali), infatti per gestirlo è fondamentale un approccio multidisciplinare (farmacologico, riabilitativo e psico-educativo). In questo scenario, la PNE (Pain Neuroscience Education) è una tecnica educativa mirata a “riconcettualizzare” il dolore, spiegandone i meccanismi di base ai pazienti, è molto usata per quelli con dolore cronico da sensibilizzazione centrale. Obiettivi: valutare l’effic

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Carcolé, Estrada Mireia 1988. "Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668154.

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Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited efficacy and significant side effects. Understanding the neurobiological mechanisms involved in the development and maintenance of this chronic pain condition and the pain-related comorbidities is crucial to develop novel therapeutic alternatives. The present thesis is focused on the role of the sigma-1 receptor (σ1R), a chaperone expressed in key areas for pain control, mo

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Custodio, Lilian. "SPINAL KAPPA OPIOID RECEPTOR ACTIVITY INHIBITS ADENYLYL CYCLASE-1 DEPENDENT MECHANISMS OF CHRONIC POSTOPERATIVE PAIN." UKnowledge, 2019. https://uknowledge.uky.edu/physiology_etds/42.

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Chronic postoperative pain impacts millions of individuals worldwide that undergo a variety of surgical procedures. Opioids remain the mainstay analgesics of acute and perioperative pain; however, prolonged opioid therapy may lead to life-threating adverse effects, tolerance, dependence, and addiction. Therefore, unraveling the cellular mechanisms that drive persistent pain states and opposing endogenous analgesia provided by opioid receptor signaling, may lead to novel analgesics. Evidence suggests that tissue injury leads to increased sensitization of the spinal cord nociceptive neurons whic

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Neto, João Pedro Oliveira dos Santos. "Alterações no processamento central e na função dos sistemas inibitórios descendentes em utentes com Dor Lombar Crónica." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Saúde, 2018. http://hdl.handle.net/10400.26/25494.

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Relatório do Projeto de Investigação apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Fisioterapia, área de especialização em Fisioterapia em Condições Músculo-Esqueléticas<br>Introdução: A Dor Lombar Crónica (DLC) é a condição músculo-esquelética mais prevalente da população portuguesa. Tendo em conta a sua natureza multidimensional, a evidência sugere que o critério tempo (mais de 12 semanas de duração) não caracteriza adequadamente os utentes com DLC, sendo importante avaliar os mecanismos de produção de dor subjacentes. Objetivo: Investigar a p

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Paz, Carolina Ribeiro Freitas da. "Clínica médica e cirúrgica em animais de companhia." Master's thesis, Universidade de Évora, 2016. http://hdl.handle.net/10174/19611.

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O presente relatório está inserido no âmbito da unidade curricular do Estágio Curricular do Mestrado Integrado em Medicina Veterinária da Universidade de Évora, sob orientação da Drª Sónia Lucena e coorientação da Drª Ângela Martins. Encontra-se dividido em duas partes, a primeira é referente à casuística acompanhada no Hospital Veterinário da Arrábida e Centro de Reabilitação Animal da Arrábida durante o período de cinco meses de estágio. Na casuística são expostos de forma breve os casos clínicos e procedimentos acompanhados durante o período de estágio. Na segunda parte é desenvolvida uma m

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Zanette, Simone de Azevedo. "Sistema modulador descendente da dor na fibromialgia : mediadores séricos e efeito da melatonina: ensaio clínico fase II, double-dummy, controlado." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/98468.

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Introdução: A fibromialgia (FM) é uma síndrome de dor crônica musculoesquelética difusa, cuja etiologia não está totalmente conhecida. A síndrome cursa com dor, alterações do humor e sintomas de ruptura do ritmo circadiano. Sabe-se que seu processo fisiopatogênico envolve um desbalanço entre os sistemas de modulação excitatório e inibitório da dor. A capacidade do sistema modulatório inibitório está enfraquecida, com hiperativação de neurônios e da neuroglia, constituindo um quadro de sensibilização central. Portanto, estudos adicionais são necessários para compreender a relação entre possívei

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del, Pozo Blanco Olga. "Efectos sobre el dolor y la función de la terapia del espejo en el síndrome del túnel del carpo bilateral." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/454720.

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La finalitat d'aquesta tesi és evaluar els efectes sobre el dolor i la funció que té la teràpia de l'espill al síndrom del túnel carpià bilateral, i a més, observar la relació entre el catastrofisme associat al dolor en la lesió, i els efectes de la tècnica. Un total de 18 pacients derivats del Servei de Traumatologia de l'Hospital de Manises de València (Espanya), participaren a l'assaig clínic, els quals van ser inclossos aleatòriament entre el grup espill i el placebo. Els pacients van emplenar qüestionaris per a avaluar el dolor, la funció i el catastrofisme associat al dolor. Durant les

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Hazime, Fuad Ahmad. "Eficácia analgésica da estimulação elétrica cerebral e periférica na dor lombar crônica inespecífica: ensaio clínico aleatorizado, duplo-cego, fatorial." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-24022016-115652/.

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Recentes evidências sugerem que a dor lombar crônica está associada a alterações plásticas no cérebro, que podem ser modificadas por estratégias de neuromodulação. Neste ensaio clínico investigamos a eficácia analgésica de 12 sessões não consecutivas de estimulação transcraniana por corrente contínua (ETCC), estimulação elétrica periférica (EEP), ETCC+EEP e estimulação simulada (sham) em 92 pacientes com dor lombar crônica inespecífica. A intensidade, aspecto sensorial e afetivo da dor, incapacidade e percepção global de recuperação foram avaliadas antes do tratamento e quatro semanas, três e

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Sydney, Priscila Brenner Hilgenberg. "Avaliação somatossensorial do sistema trigeminal em condições dolorosas crônicas: testes quantitativos sensoriais e limiar de percepção atual." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/25/25135/tde-02092013-144216/.

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A dor crônica envolve complexos processos de gênese e condução neural e é decorrente da ativação de mecanismos periféricos e centrais de manutenção. Muitos pacientes crônicos são refratários aos diferentes tipos de tratamento propostos, o que gera a suspeita de que de alguma maneira estes não estão sendo totalmente eficazes. O objetivo deste trabalho é avaliar os mecanismos de condução, manutenção e modulação da dor em diferentes condições dolorosas crônicas. Foram avaliadas 92 mulheres, divididas em 5 grupos: Grupo I, 20 pacientes com Dor Miofascial da musculatura mastigatória; Grupo II, 20 p

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Radwani, Houda. "Modulation de la transmission nociceptive par les récepteurs métabotropiques du glutamate de groupe I et les canaux calciques de type L dans la moelle épinière : approche électrophysiologique in vivo." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0383/document.

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La douleur est une expérience désagréable qui fait partie de notre vie. Quand elle ne dure pas longtemps, elle est un signal d’alarme pour notre organisme. Cependant malheureusement, dans certaines conditions pathologiques, elle se prolonge dans le temps, elle devient alors chronique, intolérable, et nécessite un traitement qui ne suffit pas toujours à soulager le patient, un traitement qui dispose une efficacité limitée avec des effets secondaires indésirables non négligeables. Il est crucial alors d’améliorer nos connaissances sur les mécanismes enclenchés dans la transmission douloureuse po

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Borella, Federica. "Tendon Neuroplastic Training, un nuovo approccio riabilitativo per la risoluzione del dolore e il ritorno allo sport nelle persone con tendinopatia achillea e patellare. Scoping review." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21904/.

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Introduzione: le tendinopatie achillea e patellare sono le più frequenti a livello dell’arto inferiore e sono caratterizzate da sintomi persistenti quali dolore che si accentua col carico e compromissione della funzione. L’approccio riabilitativo tradizionale si basa su esercizi eccentrici isolati in carico, modalità che pare inefficace per circa il 45% dei pazienti. Stanno perciò emergendo nuove strategie riabilitative che includano altri tipi di contrazione muscolare. Si è ipotizzata una correlazione tra la persistenza dei sintomi e fenomeni di sensibilizzazione del SNC. Obiettivo: analizza

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Pergolizzi, J., K. Ahlbeck, D. Aldington, et al. "The development of chronic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment." 2013. http://hdl.handle.net/10454/7254.

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No<br>Chronic pain is currently under-diagnosed and under-treated, partly because doctors' training in pain management is often inadequate. This situation looks certain to become worse with the rapidly increasing elderly population unless there is a wider adoption of best pain management practice. This paper reviews current knowledge of the development of chronic pain and the multidisciplinary team approach to pain therapy. The individual topics covered include nociceptive and neuropathic pain, peripheral sensitization, central sensitization, the definition and diagnosis of chronic pain, the b

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Resad, Sehar. "Examining associations between psychophysical functioning and pain in young women with endometriosis and chronic pelvic pain: a pilot study." Thesis, 2017. https://hdl.handle.net/2144/23845.

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OBJECTIVES: This study aims to explore the relationships between preoperative psychosocial factors in relation to postoperative chronic pelvic pain (CPP) in adolescents and young women with endometriosis, which is a significant public health concern. As a pilot sample, there is large need to present preliminary data exploring the biopsychosocial correlates and possible predictors of central sensitization and CPP, which remains non-existent in the realm of adolescents and young adults with CPP secondary to endometriosis. METHODS: Eligible candidates included patients 12-22 years old who were

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Cherkas, Pavel S. "Trigeminal Central Sensitization and Its Modulation in Acute and Chronic Orofacial Pain Models." Thesis, 2014. http://hdl.handle.net/1807/44006.

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This study aimed to examine whether trigeminal nerve injury induces chronic nociceptive behaviour and central sensitization (CS) in functionally identified medullary dorsal horn (MDH) nociceptive neurons in mice, and whether CS in acute and chronic orofacial pain models and nociceptive behaviour in the chronic model are affected by systemic administration of pregabalin. Infraorbital nerve injury induced chronic facial mechanical allodynia as well as MDH CS; acute noxious tooth pulp stimulation also induced MDS CS. Systemic administration of pregabalin attenuated the nerve injury-induced allody

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Foad, Ghazni NIOUSHA. "Functional Magnetic Resonance Imaging of Pain in the Spinal Cord and Brainstem." Thesis, 2008. http://hdl.handle.net/1974/1481.

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Functional magnetic resonance imaging (fMRI) studies performed to date have focused on brain structures rostral to the thalamus, although the first level of sensory information and pain transmission occurs at the spinal cord (SC). The primary goal of this project is to map activity using fMRI, from the entire cervical SC and brainstem following innocuous and noxious stimuli before and after peripheral sensitization in normal human volunteers. This study is unique in that it determines functional activity throughout the lower neural axis in response to mechanical stimuli that are perceived as

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Moura, David Duarte Machado Gomes de. "Pathophysiology of Chronic Pain." Master's thesis, 2020. http://hdl.handle.net/10316/97759.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>A dor crónica é considerada uma experiência desagradável, pessoal, com carácter multidimensional, associada a um alto impacto socioeconómico, na medida em que é uma das principais causas de sofrimento, bem como de baixa produtividade e de incapacidade laboral. Devido à sua alta prevalência e impacto, constitui um dos principais motivos para a procura de cuidados de saúde por parte da população em geral. É considerada um problema de saúde pública cada vez mais frequente, afetando cerca de 40 % da população p

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Mann, Mandeep Kaur. "Peripheral mechanisms of nerve growth factor-induced masticatory muscle sensitization : a model of temporomandibular disorders pain." Thesis, 2005. http://hdl.handle.net/2429/17263.

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It has been speculated that Nerve Growth Factor (NGF), a neurotrophic protein, may play a role in the pathophysiology of temporomandibular disorders (TMD). TMD are characterized by ongoing and activity-related pain in the jaw joint and muscles, and are more prevalent in women than in men. Indeed, intramuscular injection of human NGF into the masseter (jaw closer) muscle of healthy male subjects, though not acutely painful, does cause a prolonged period of activity-related muscle pain reminiscent of TMD symptoms [187]. The present study tested whether this human NGF-induced mechanical sen

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Becker, Susanne [Verfasser]. "Implicit operant learning of pain sensitization and habituation in healthy participants and fibromyalgia patients / Susanne Becker." 2009. http://d-nb.info/995967768/34.

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Tikàsz, Andràs. "Increased spinal pain sensitization : a new explanation for highly prevalent painful somatic symptoms in major depressive disorder?" Thèse, 2015. http://hdl.handle.net/1866/13480.

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Objectifs: Malgré que les patients souffrant de dépression majeure (DM) rapportent souvent des symptômes douloureux, la relation entre la douleur et la dépression n’est pas encore claire. Ce n’est que récemment que des études employant des paradigmes de sommation temporelle ont pu offrir une explication préliminaire de la cooccurrence de la douleur et de la dépression. Notre étude vise à évaluer la contribution des procédés spinaux et surpraspinaux dans la sensibilisation de la douleur dans la DM en utilisant un paradigme de sommation temporelle. Participants : Treize sujets sains et quatorze

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You, Dokyoung Sophia. "The Impact of Adverse Childhood Events on Temporal Summation of Second Pain." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11796.

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Adverse childhood events have been identified as a risk factor for developing chronic pain conditions in adulthood. However, previous studies have inconsistently supported the link between adverse childhood events and hypersensitivity to laboratory-induced pain. Therefore, this study intended to investigate the effects of adverse childhood events on temporal summation of second pain (TSSP). A group of 38 healthy and pain-free college students participated in laboratory pain tests after being screened for childhood trauma history. Half of participants (47.5% female) were positive for childhood

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Barszczyk, Andrew. "A Peptide Comprising the Src-interacting Domain of NADH Dehydrogenase Subunit 2 Alleviates Complete Freund's Adjuvant-induced Allodynia in Rats." Thesis, 2010. http://hdl.handle.net/1807/25421.

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Inflammatory and neuropathic pains arise in part from sensitization at nociceptive synapses in the spinal cord. Activity-dependent signaling cascades converge onto the tyrosine kinase Src, which participates in augmenting the function of N-methyl-D-aspartate receptors (NMDARs) and thus potentiates the nociceptive system. Src is capable of these effects because it is anchored to the NMDAR complex via an adaptor protein called NADH dehydrogenase subunit 2 (ND2). There is evidence that this interaction occurs between amino acids 40-49 of Src and amino acids 310-321 of ND2. I have determined that

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Huntley, Devon. "Examining the role of comorbid factors in the development of central sensitization with chronic pelvic pain in cases of adolescent endometriosis." Thesis, 2018. https://hdl.handle.net/2144/30791.

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OBJECTIVES: This study aims to better understand the relationship between psychosocial factors and the development of chronic pelvic pain (CPP) in cases of adolescent endometriosis, specifically mood disorders, pain catastrophizing and quality of life, and to detect the development of central sensitization within this population. METHODS: Eligible candidates were patients between 14 and 22 years old with confirmed diagnosis of endometriosis and chronic pelvic pain who were enrolled in the Women’s Health Study: From Adolescence to Adulthood through the Boston Center for Endometriosis (BCE) an

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Stemkowski, Patrick. "The effect of long-term interleukin-1 beta exposure on sensory neuron electrical membrane properties: implications for neuropathic pain." Phd thesis, 2011. http://hdl.handle.net/10048/1713.

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The effect of interleukin-1 beta (IL-1β) on the electrical properties of sensory neurons was assessed at comparable levels and exposure times to those found in animal models of neuropathic pain. Experiments involved whole cell current- or voltage-clamp recordings from rat dorsal root ganglion (DRG) neurons in defined medium, neuron enriched cultures. 5-6 days exposure to 100 pM IL-1β produced neuron specific effects. These included an increase in the excitability of medium diameter and small diameter isolectin B4 (IB4)-positive neurons that was comparable to that found after peripheral nerve

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Siebertz, Mathias Walter. "Zentrale Sensibilisierung, Schmerzlokalisation und -ausdehnung bei Arthrose des Hüftgelenks." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-13A7-9.

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Farrell, Kristen Elise. "Investigation of visceral sensory processing mechanisms in the superficial dorsal horn of the spinal cord." Thesis, 2017. http://hdl.handle.net/1959.13/1335508.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Pain is the most common symptom of inflammatory diseases of viscera or the gastrointestinal tract. Importantly, pain occurs during active disease and often persists during clinical remission. The specific functional mechanisms underlying the development and maintenance of visceral pain are not known. To date, functional studies have focussed on the peripheral nervous system, using gut-nerve preparations, in animal models of visceral hypersensitivity. Clinical studies, however, suggest changes in the central nervous system CNS contribute to alt

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Rialland, Pascale. "Métrologie de la douleur animale : validation sur des modèles de douleur viscérale bovine et articulaires canins." Thèse, 2013. http://hdl.handle.net/1866/11441.

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La douleur est une expérience multidimensionnelle comportant des aspects sensoriels, émotionnels et cognitifs. Théoriquement, des méthodes de mesures comportementales, physiologiques, neurophysiologiques et sensorielles peuvent quantifier la douleur. Peu d’études ont étudié la validation des mesures utilisées en médecine vétérinaire. La recherche combine les travaux de Maîtrise et de Doctorat, traite en partie de la validité de méthodes. Dans cet objectif, nos travaux de recherche étudiaient la validité de méthodes comportementales, physiologiques et neurophysiologiques usuelles pour la

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Otis, Colombe. "Métrologie de la douleur animale sur modèles expérimentaux : développement et validation de biomarqueurs neuroprotéomiques." Thèse, 2017. http://hdl.handle.net/1866/21067.

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Hollasová, Sára. "Proměnné predikující efekt operace u pacientů s bolestí zad." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-435778.

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Variables predicting the effects of surgery in patients with low back pain Abstract The theoretical part of the thesis summarizes the knowledge about pain and its types, especially chronic pain. Than we focus on low back pain and currently used approaches in the treatment of this syndrome. In this work we summarize the influence of central sensitization and adverse life experineces and posttraumatic stress disorder on pain (especially low back pain). In the practical part, we investigated the effect of central sensitization and adverse life events and posttraumatic stress disroder on the effec

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Park, Kellie Adrienne. "Cellular Mechanisms Mediating the Actions of Nerve Growth Factor in Sensory Neurons." Thesis, 2007. http://hdl.handle.net/1805/1127.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Nerve growth factor (NGF) is a neurotrophin upregulated with injury and inflammation. Peripheral administration of NGF causes hyperalgesia and allodynia in animals. Blocking NGF signaling reverses these effects. At the cellular level, chronic exposure of sensory neurons to NGF enhances expression the neurotransmitter, calcitonin gene-related peptide (CGRP). Acute exposure to NGF increases capsaicin-evoked CGRP release from sensory neurons in culture. Thus, NGF increases peptide release from neurons by: (1) increasing expression of pe

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