Gotowe bibliografie tematyczne / Pathologic/drug therapy

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Gotowa bibliografia na temat „Pathologic/drug therapy”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Pathologic/drug therapy"

He, Yong-Gang, Zheng Wang, Jing Li, et al. "Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids: A case report." World Journal of Gastrointestinal Oncology 16, no. 11 (2024): 4506–13. http://dx.doi.org/10.4251/wjgo.v16.i11.4506.

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BACKGROUND For primary liver cancer, the key to conversion therapy depends on the effectiveness of drug treatment. Patient-derived tumor organoids have been demonstrated to improve the efficacy of conversion therapy by identifying individual-targeted effective drugs, but their clinical effects in liver cancer remain unknown. CASE SUMMARY We described a patient with hepatocellular carcinoma (HCC) who achieved pathologic complete response (pCR) to conversion therapy guided by the patient-derived organoid (PDO) drug sensitivity testing. Despite insufficiency of the remaining liver volume after he

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Arend, Lois J., and Tibor Nadasdy. "Emerging Therapy-Related Kidney Disease." Archives of Pathology & Laboratory Medicine 133, no. 2 (2009): 268–78. http://dx.doi.org/10.5858/133.2.268.

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Abstract Context.—Many new therapies have emerged within the last 5 to 10 years to treat a variety of conditions. Several of these have direct or indirect renal toxicities that may go undiagnosed without careful attention of the pathologist to a patient's clinical history, particularly the addition of new medications or treatments. Objective.—To discuss patterns of renal injury resulting from medications or therapeutic regimens that have been introduced within the last 10 years. Recognition of these patterns may allow the pathologist to alert the attending clinician to a possible drug-induced

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Yong Lu, Da, Hong Ying Wu, and Ting Ren Lu. "HIV/AIDS treatment, therapeutic strategy break throughs." Hospice & Palliative Medicine International Journal 4, no. 2 (2020): 34–39. http://dx.doi.org/10.15406/hpmij.2020.04.00182.

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HIV/AIDS is currently an incurable viral infectious disease characterized with life-long drug utility. To overcome this therapeutic setback, fatal pathological processes and different therapeutic mechanisms must be explored in broader-range and greater dimension. In this Article, the major types of global HIV/AIDS therapeutic strategies (pharmaceutical modification, herbal medicine, novel drug targets, drug combination modality, animal models, palliative medicine, immune-stimulate for HIV latency as well as HIV clearance by biological-based therapy) are especially highlighted. After novel path

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Hur, Junseok W. "Conservative treatment of senile spinal diseases: drug therapy and nerve block." Journal of the Korean Medical Association 64, no. 3 (2021): 185–90. http://dx.doi.org/10.5124/jkma.2021.64.3.185.

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As we get closer to super-aged society, the prevalence of senile spinal diseases is constantly increasing and the burden on individuals and society grows high. Senile spinal disease is basically degenerative in nature. Pain and physical dysfunction occur due to various complex pathologic causes. For the diagnosis and treatment of such complex diseases, it is essential to understand common senile spinal diseases such as intervertebral disc herniation and spinal stenosis. Degenerative changes in intervertebral discs are caused by a combination of aging and excessive physical load, which results

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Ruff, Samantha M., and Timothy M. Pawlik. "A Review of Translational Research for Targeted Therapy for Metastatic Colorectal Cancer." Cancers 15, no. 5 (2023): 1395. http://dx.doi.org/10.3390/cancers15051395.

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Colorectal cancer is the third most common cause of cancer-related death in the United States, with 20% of patients presenting with metastatic disease at the time of diagnosis. Metastatic colon cancer is often treated with a combination of surgery, systemic therapy (chemotherapy, biologic therapy, immunotherapy), and/or regional therapy (hepatic artery infusion pumps). Utilizing the molecular and pathologic features of the primary tumor to tailor treatment for patients may improve overall survival. Rather than a “one size fits all” approach, a more nuanced treatment plan guided by the unique f

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Sudo, Naohiro, and T. J. Yoo. "Effect of Anti-Inflammatory Drugs on Collagen-Induced Autoimmune Inner Ear Disease." Annals of Otology, Rhinology & Laryngology 97, no. 2 (1988): 153–58. http://dx.doi.org/10.1177/000348948809700212.

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Animals that had collagen-induced autoimmune inner ear disease were treated with anti-inflammatory drugs: Solu-Medrol (steroid), sulindac (nonsteroid), or a combination of both. Temporal bones from drug-treated animals were examined for histopathologic and immunohistochemical changes, and sera were examined for levels of circulating antibody to type II collagen. Therapy was beneficial to the animals whether the drugs were administered alone or in combination; however, fewer lesions were observed in animals given either drug alone. Further, animals treated with steroid alone showed the least am

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Eristavi, S. Kh, R. V. Rozhivanov, E. R. Rozhivanova, E. N. Andreeva, G. A. Mel’nichenko, and N. G. Mokrysheva. "Gynecomastia: pathogenesis and approaches to treatment." Bulletin of Reproductive Health 4, no. 1 (2025): 32–38. https://doi.org/10.14341/brh12752.

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Gynecomastia is a benign enlargement of the breast glands in men that can be physiologic, pathologic, or idiopathic. Physiologic gynecomastia can occur in children and during puberty. Pathologic gynecomastia is associated with various endocrine, genetic disorders, systemic diseases, paraneoplastic processes, or may be iatrogenic. Common causes of pathologic gynecomastia are hypogonadism, testicular or adrenal tumors producing estrogens, androgen excess syndromes with aromatization, androgen deficiencies, hepatopathy, and nephropathy. Most commonly, the underlying cause of gynecomastia is an im

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Liu, Kang, and Bolin Xie. "Today and Future of Age-Related Macular Degeneration." ISRN Ophthalmology 2012 (April 4, 2012): 1–9. http://dx.doi.org/10.5402/2012/480212.

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Age-related macular degeneration (AMD) is the leading cause of blindness in people over 50 in developed countries. Understanding of the pathologic process, genetic mechanisms, and risk factors of this disease has the benefit of seeking newer and more effective treatment options. Current clinical therapy for AMD shows a dramatic change from a decade ago. Anti-VEGF drug therapy is regarded as the more effective treatment for neovascular AMD now, especially combining PDT therapy. In the future, the genetic and biochemical therapies may be the promising treatments for AMD. This paper will focus on

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Cagle, Philip T., and Lucian R. Chirieac. "Advances in Treatment of Lung Cancer With Targeted Therapy." Archives of Pathology & Laboratory Medicine 136, no. 5 (2012): 504–9. http://dx.doi.org/10.5858/arpa.2011-0618-ra.

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Context.—Ongoing preclinical investigations and clinical trials involving new targeted therapies promise to improve survival for patients with lung cancer. Targeted therapeutic agents, based on genetic mutations and signaling pathways altered in lung cancer, have added significantly to our armamentarium for lung cancer treatment while minimizing drug toxicity. To date, 4 targeted therapies have been approved for treatment of lung cancer by the US Food and Drug Administration: gefitinib in 2002, erlotinib in 2003, bevacizumab in 2006, and crizotinib in 2011. Objective.—To review targeted therap

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Rastogi, Priya, Charles E. Geyer, Eleftherios P. Mamounas, and Angela DeMichele. "Drug Development: Neoadjuvant Opportunities in Breast Cancer." American Society of Clinical Oncology Educational Book, no. 33 (May 2013): 73–79. http://dx.doi.org/10.14694/edbook_am.2013.33.73.

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Preoperative therapy allows for a higher rate of breast conserving surgery and has been shown equivalent to adjuvant therapy. Preoperative therapy provides an opportunity to obtain insights into breast cancer biology and to accelerate the evaluation of new therapies. Clinical trials have shown that women who achieve a pathologic complete response (pCR) have substantially improved outcomes compared with those who do not achieve a pCR. The U.S. Food and Drug Administration (FDA) meta-analysis demonstrated that the association of pCR and long-term outcomes is greater in women with aggressive brea

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Rozprawy doktorskie na temat "Pathologic/drug therapy"

Arif, Khalid. "Evaluation of hormonal receptors in breast cancer drug therapy." Thesis, University of Lincoln, 2014. http://eprints.lincoln.ac.uk/14682/.

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Breast cancer is the most common type of cancer in women worldwide. Approximately two-thirds of breast cancers are oestrogen receptor positive (ER+), which are activated via oestrogen dependent and independent mechanisms. The pathogenic role of oestrogen in breast cancer is well established, thus, targeting ER becomes an essential target in breast cancer anti-hormonal therapy. Tamoxifen is the most important anti-hormonal therapeutic agent which has been used as the gold standard in the treatment of ER+ breast cancer patients. Tamoxifen acts by competing with oestrogen for binding to the ER an

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Barua, Neil U. "Convection-enhanced drug delivery and its application to Alzheimer's disease." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617593.

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Hall, Courtney D., Emily Grieshaber, Blaine Hendricks, et al. "Identification of Older Adults at Risk for Falls with Drug-Based Indices." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/7781.

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Purpose/Hypothesis: Falls in the older adult population are the leading cause of fatal and non-fatal injuries in America. Polypharmacy, the use of multiple medications, has been identified as a major risk factor for falls in older adults. A variety of medication screens exist that identify adverse effects of medications which can directly impact fall risk; however, current screening measures have limitations. The Quantitative Drug Index (QDI) is a new, clinically anchored index to quantify all potential adverse eﬀects associated with drug-mediated fall risk. The purpose of this study was to va

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Van, Zyl Gert Uves. "The investigation of genotypic antiretroviral drug resistance in the context of the South African national antiretroviral roll-out programme." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20254.

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Thesis (PhD)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Introduction: Since the South African public sector antiretroviral roll-out programme started in 2004, the success of antiretroviral combination therapy (cART) has been experienced in terms of survival, prevention of mother-to-child transmission (PMTCT) and quality of life. However, as the programme matures, viral resistance to the constituent drugs will increase. Monitoring antiretroviral drug resistance (ARVDR) should therefore be a priority in the public health approach to HIV treatment. Methods: A cross-sectional investigat

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Sharp, III Thomas E. "DRUG AND CELL–BASED THERAPIES TO REDUCE PATHOLOGICAL REMODELING AND CARDIAC DYSFUNCTION AFTER ACUTE MYOCARDIAL INFARCTION." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/445275.

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Physiology<br>Ph.D.<br>Remarkable advances have been made in the treatment of cardiovascular diseases (CVD), however, CVD still accounts for the most deaths in industrialized nations. Ischemic heart disease (IHD) can lead to acute coronary syndrome (ACS) (myocardial infarction [MI]). The standard of care is reperfusion therapy followed by pharmacological intervention to attenuate clinical symptoms related to the MI. While survival from MI has dramatically increased with the implementation of reperfusion therapy, these individuals will inevitably suffer progressive pathological remodeling leavi

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Panus, Peter C. Pharm, Courtney D. Hall, Zachary F. Pharm Walls, and Brian L. Pharmacy Practice Odle. "Influences of Age, Obesity, and Adverse Drug Effects on Gait Speed in Community-dwelling Older Adults." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/581.

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Hall, Courtney D. "Fall Risk." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/560.

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Ngandu, Jean Pierre Kabue. "Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2219.

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Thesis (MScMedSc (Pathology. Medical Virology))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: In 2007, AIDS caused an estimated 2.1 millions deaths worldwide; about 70% in sub-Saharan Africa. HIV preferentially targets activated CD4 T cells, expressing the major HIV receptor CD4, as well as the major chemokine coreceptors CCR5 and CXCR4. These coreceptors play a prominent role during HIV cell entrance phase, HIV transmission and also disease progression. They have been found to be differentially expressed by CD4 T cell subsets. Tuberculosis coinfection may enhance immune activat

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Khalili, Boroojeni Parisa. "Evaluation of the effect of trastuzumab (Herceptin) on the development and progression of breast cancer associated skeletal metastasis." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112523.

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Breast cancer is the most commonly diagnosed cancer in women. Despite recent advances in screening and early detection, breast cancer continues to result in a high incidence of morbidity and mortality. In its late stage the majority of patients exhibit signs of destructive skeletal metastasis. This complication is promoted by the production of growth factors by tumor cells which can induce tumor cell proliferation via their interaction with their respective receptors to initiate the vicious cycle of bone resorption. Inhibition of growth factors signaling through their receptors can therefore s

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Ignatz-Hoover, James J. "TLR8 and Nuclear GSK3ß are Novel Therapeutic Targets in AML." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1480509044211523.

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Książki na temat "Pathologic/drug therapy"

1952-, Teicher Beverly A., ed. Antiangiogenic agents in cancer therapy. Humana Press, 1999.

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1934-, Green David, ed. Anticoagulants: Physiologic, pathologic, and pharmacologic. CRC Press, 1994.

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D, Marmé, and Fusenig N. E, eds. Tumor angiogenesis: Basic mechanisms and cancer therapy. Springer, 2007.

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W, Siemann Dietmar, ed. Vascular-targeted therapies in oncology. J. Wiley, 2006.

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E, Golan David, ed. The pathophysiologic basis of drug therapy. 2nd ed. Lippincott Williams & Wilkins, 2008.

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E, Golan David, ed. Principles of pharmacology: The pathophysiologic basis of drug therapy. 2nd ed. Wolters Kluwer Health/Lippincott Williams & Wilkins, 2008.

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E, Schönbaum, and Lomax Peter 1928-, eds. Thermoregulation: Pathology, pharmacology, and therapy. Pergamon Press, 1991.

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Zdanowicz, Martin M. Essentials of pathophysiology for pharmacy. CRC Press, 2003.

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E, Voest Emile, and D'Amore Patricia A, eds. Tumor angiogenesis and microcirculation. Dekker, 2001.

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Gomtsyan, Arthur. Vanilloid receptor TRPV1 in drug discovery: Targeting pain and other pathological disorders. Wiley, 2010.

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Części książek na temat "Pathologic/drug therapy"

Schiller, Erich. "Antitumour Drug Therapy." In Free Radicals and Inhalation Pathology. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18619-6_21.

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Halford, J. C. G., and J. E. Blundell. "Serotonin Drugs and the Treatment of Obesity." In Obesity: Pathology and Therapy. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59651-3_7.

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Workman, Paul. "Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-40204-4_11.

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Abstract This personal perspective focuses on small-molecule inhibitors of proteostasis networks in cancer—specifically the discovery and development of chemical probes and drugs acting on the molecular chaperones HSP90 and HSP70, and on the HSF1 stress pathway. Emphasis is on progress made and lessons learned and a future outlook is provided. Highly potent, selective HSP90 inhibitors have proved invaluable in exploring the role of this molecular chaperone family in biology and disease pathology. Clinical activity was observed, especially in non small cell lung cancer and HER2 positive breast

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Liu, Wei, Xiaoli Wu, Zheng Gao, and Lingling Xia. "Minimally Invasive Technologies for Treatment of HTS and Keloids: Low-Dose 5-Fluorouracil." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_30.

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AbstractBoth hypertrophic scar (HTS) and keloid are pathological scars that tend to overgrow and overproduce extracellular matrices, lead to large-sized scars along with severe pain and itching, and even result in functional disability. In particular, keloids are considered as benign skin tumors due to their nature of uncontrolled growth beyond the original wound boundary and invasion into normal skin; therefore, anticancer therapy has been employed in keloid therapy. 5-Fluorouraci (5-FU), a pyrimidine analog, is a commonly used chemotherapy agent and it has also been previously used in keloid

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Karagecili, Hasan. "Potential Medicinal Plants Used in the Treatment of Alzheimer’s Disease." In Neurological Diseases and Treatments in Terms of Biochemistry. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359357.5.

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Alzheimer’s disease is a progressive and chronic neurodegenerative disease of the brain and is the disease with the most involvement in dementia, with 50 million patients in the world. The following medications have been used to treat AD symptoms: galantamine, donepezil, rivastigmine, physostigmine (eserine), tacrine, and huperzine A. Their main method of action is AChE suppression to minimize the cholinergic deficit. The use of FDA-approved these drugs in treatment is aimed at short-term relief of symptoms rather than regressing the course of the disease. While FDA-approved anti-AD drugs are

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S. Ahmed, Sunbul. "Corticosteroids in Neuro-Oncology: Management of Intracranial Tumors and Peritumoral Edema." In Corticosteroids - A Paradigmatic Drug Class. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100624.

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Corticosteroids have been in use for decades and are one of the most prescribed drugs in all specialties of medicine. Jerome Posner, in his classic textbook “Neurological Complications of Cancer,” refers to corticosteroids as widely used drugs in neuro-oncology leading to a remarkable decline in perioperative mortality and morbidity rates. Being the most powerful class of tumor-induced-edema reducing agents, they are adjuvant to chemotherapy and are also known to reduce the risk of encephalopathy and other associated neurological deficits in patients undergoing radiation therapy. They have bee

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Cascino, Dr Gregory D. "Intractable partial epilepsy of left frontal lobe origin related to focal cortical dysplasia." In Fifty Neurologic Cases From Mayo Clinic. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195177442.003.0004.

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Abstract Pathologic examination of the epileptic brain tissue showed focal cortical dysplasia. The patient has been seizure-free and asymptomatic for more than 5 years after resection. There were no operative complications. The patient’s behavior and neurocognitive performance have improved markedly, and he is now employed and does not require supervision. Also, there has been a pronounced reduction in the adverse effects of antiepileptic drug medication. Partial or localization-related epilepsy is the most common seizure disorder. Approximately 90% of the adult incident cases of epilepsy have

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Grahame-Smith, D. G., and J. K. Aronson. "Introduction to drug therapy." In Oxford Textbook of Clinical Pharmacology and Drug Therapy. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780192632340.003.0021.

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Abstract In Section I, we discussed the basic principles of clinical pharmacology, breaking down drug therapy into its component processes (pharmaceutical, pharmacokinetic, pharmacodynamic, and therapeutic). In Section II, we discussed some principles relating to the prescribing of drugs. Section IV (the Pharmacopoeia) contains details of the properties of individual drugs or groups of drugs. In this section, it is our aim to marry the properties of the drugs with the basic principles, and to link both with the pathology of the disease and its manifestations, in order to illustrate the ways in

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"Pathological specimen examinations." In Drug Therapy in Cardiology. CRC Press, 2001. http://dx.doi.org/10.3109/9780203213476-31.

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Rosen, Gerald M., Bradley E. Britigan, Howard J. Halpern, and Sovitj Pou. "The Pharmacological Activity of Spin Traps." In Free Radicals. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195095050.003.0011.

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Abstract An underlying theme of this book is that spin traps, by reacting with free radicals, compete with biologic targets for these reactive species. As such, nitrones and nitrosoalkanes can be perceived as inhibitors, interrupting the cascade of reactions at specific sites (Kalyanaraman, et al., 1991, 1993; Thomas, et al., 1994a, 1994b). Consider, for example, the competition between nitrosoalkanes and 02 for the carbon-centered free radical derived from either linoleic acid (Aoshima, et al., 1977) or arachidonic acid (Mason, et al., 1980). The efficiency of these processes is, however, not

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Streszczenia konferencji na temat "Pathologic/drug therapy"

Freitas, Paola Ferreira, Juliana Costa Souza, Andre Mattar, Jorge Yoshinori Shida, and Luiz Henrique Gebrim. "NEOAJUVANT ENDOCRINE THERAPY IN BREAST CANCER: THE FIRST RESULTS OF 59 PATIENTS." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1086.

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Introduction: Luminal breast cancer cases, those with positive hormone receptors and human epidermal growth factor (HER 2) negative range around 70% of cases and it is known to be more frequent in older patients. Out of the neoadjuvant therapies, neoadjuvant endocrine therapy (NET) has been gaining more ground due to fewer side effects and tumor downstaging, making it possible for advanced breast cancer tumor patients to undergo breast conservation surgery (BCS). Objectives: To evaluate clinical and pathological response in women that underwent NET with Anastrozole (ANAS) at Pérola Byington Ho

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Bonadio, Renata Rodrigues da Cunha Colombo, Monique Tavares, Daniela Dornelles Rosa, et al. "Dose-dense versus 3-weekly ac during neoadjuvant chemoimmunotherapy for early-stage triple-negative breast cancer: GBECAM 0123 – the neo-real study." In Brazilian Breast Cancer Symposium 2024. Mastology, 2024. http://dx.doi.org/10.29289/259453942024v34s1014.

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Objective: This analysis aims to evaluate the effectiveness and safety of dose-dense AC (ddAC) compared with every 3 weeks (q3w) AC during neoadjuvant pembrolizumab plus chemotherapy (P+CT) for triple-negative breast cancer (TNBC). Methodology: The Neo-Real study is a collaborative real-world data effort evaluating patients treated with neoadjuvant P+CT since July 2020 in 10 cancer centers. Effectiveness endpoints were pathologic complete response (pCR) and residual cancer burden (RCB) 0–1. Factors associated with pCR and RCB 0–1 were also explored. Safety endpoints included drug discontinuati

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Finageev, E. Yu, and T. Sh Kuznetsova. "Complex therapy of postpartum endometritis in cows using estrofantin." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-11-57-63.

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Postpartum endometritis is a common pathology in fresh cows, the morbidity of which can reach 50% or more. The causes of endometritis include retention of the placenta and, as a result, placentitis, atony of the uterus, infection of the birth canal, etc. 19 fresh cows were examined, 7 of them were diagnosed with postpartum endometritis. The drug Estrofantin, the active ingredient of which is prostaglandin F2α, was used in complex therapy with the drugs Uteroklin-T and Metrostim-Bel. Animals recovered on the 13th day from the start of therapy. This protocol for the treatment of endometritis in

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Sheenkova, M. V. "ON THE PATHOGENESIS OF GASTRODUODENAL ZONE LESIONS IN VARIOUS VARIANTS OF DRUG THERAPY FOR OCCUPATIONAL RESPIRATORY DISEASES." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-575-578.

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Abstract. A survey of workers of large industrial enterprises with occupational diseases of the respiratory system was conducted to assess the dependence of the risk of damage to the upper gastrointestinal tract on the features of pharmacological therapy of respiratory pathology. The specificity of the pathogenesis of gastric and duodenal lesions associated with the properties of drug treatment of occupational respiratory diseases was revealed.

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Goette, Matthew J., Jana G. Delfino, Brandon K. Fornwalt, and John N. Oshinski. "A New Method to Diagnose Left Ventricular Dyssynchrony With Analysis of Heart Wall Thickening From Cardiac CT." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192629.

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Left ventricular (LV) dyssynchrony is a pathological condition in which segments of the myocardial wall contract at different times. This dyssynchrony results in a decreased LV ejection fraction (EF) and an increased level of mitral regurgitation. LV dyssynchrony has been linked to higher rates of morbidity, mortality, and arrhythmic susceptibility in patients with congestive heart failure. Cardiac resynchronization therapy (CRT) with biventricular pacemakers has benefited patients with drug-refractory heart failure and signs of ventricular dyssynchrony. Patients are currently selected for CRT

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Rovito, Nick, and Debanjan Mukherjee. "In Silico Analysis of Flow-Mediated Drug Transport for Thrombolytic Therapy in Acute Ischemic Stroke." In ASME 2024 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2024. https://doi.org/10.1115/imece2024-143625.

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Abstract Acute Ischemic Stroke (AIS) is a life threatening condition that occurs when an artery within the brain is blocked by a pathological blood clot, called a thrombus. The most popular treatment approach for AIS relies on intravenous administration of a drug named tissue plasminogen activator (tPA) to dissolve fibrin fibers within the clot. Despite the widespread use of tPA, treatment outcomes are often unsuccessful. This is commonly attributed to local clot-flow interactions and their effect on drug delivery into a thrombus. Yet, detailed characterization of flow-mediated drug transport

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Rezende, Karla Viana, Ayrton Senna do Brasil Amaral Alves, Juliana Carollyne Amorim, Maria Inês Vaz de Oliveira, Maria Paula Banhara Rodrigues, and Vitor Matias Grah. "Helminth-induced immune response: A new perspective for the treatment of Multiple Sclerosis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.603.

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Background: Multiple Sclerole (MS) is a progressive neurodegenerative disease that, in its most common form, evolves in outbreaks and compromises the patient’s quality of life and functionality. In a long time, a way of attenuating symptoms and preventing the progression of this pathology has been studied, however, drug therapies, until now, have not shown good accuracy. In this context, the exogenous use of helminths as non-drug therapy for MS has been considered, therefore, this study aims to demonstrate the recent results of studies on such therapies and verify whether there is scientific e

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Lashin, A. "EFFECTIVENESS OF PHARMACOCORRECTION IN THE BACKGROUND OF GASTROENTERITIS IN COWS." In SCIENTIFIC SUPPORT FOR LIVESTOCK BREEDING IN SIBERIA. Krasnoyarsk Scientific Research Institute of Agriculture is a separate division of the Federal Research Center KSC SB RAS, 2024. https://doi.org/10.52686/conferencearticle_67597cefa11c05.17985122.

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A comparative assessment of various pharmacocorrection schemes against the background of gastroenteritis in cows was carried out, followed by an analysis of the clinical status, hematological profile, and scatological examination data. The object of the research were cows that had disturbances in the gastrointestinal tract, with signs of gastroenteritis. The results of the study showed that the use of the probiotic drug "Vitaflor", against the background of the main measures of drug treatment of gastroenteritis, eliminates the main signs of the disease on the 7th day in the experimental group

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Carneiro, Gabriela Coutinho Amorim, Deborah Calado Coelho, and Suzana Bastos Batista. "Deep Brain Stimulation (DBS) in the treatment of primary dystonia of the pediatric population: a review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.596.

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Background: Deep Brain Stimulation (DBS) is a neurosurgical technique widely used for the treatment of several pathologies, such as Parkinson’s Disease and dystonias. Dystonias, primary or secondary, have several determining factors, among which we can mention genetic mutations, that, generally, do not respond satisfactorily to drug treatments. The difficult control of dystonias makes its management complex, since they are progressive, and, as a consequence, surgical options are often necessary. Objectives: To identify the impact of the use of DBS on the prognosis of children with primary dyst

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Radenkovic, Miroslav. "Pharmacogenomics and uncontrolled arterial hypertension." In 7th International Congress of Cardionephrology KARNEF 2025. Punta Niš, 2025. https://doi.org/10.46793/karnef25.336r.

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Arterial hypertension is the principal source of chronic noncommunicable pathological disorders. Low adherence, ineffective therapy, and a frequent lack of distinct clinical signs are linked to the excessive occurrence of uncontrolled and undiagnosed clinical cases. Resistant hypertension (RH) is a condition where blood pressure remains elevated and uncontrolled, despite the use of three or more antihypertensive medications, including a diuretic, at optimal doses. Thus, it is essential to develop individualized treatment plans, considering patients’ overall health, medication tolerability, and

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Raporty organizacyjne na temat "Pathologic/drug therapy"

Kumar, Aishani, Thendral Yalini, and Sunil Kumar C. Unlocking Cellular Control: The Promise of PROTACs in Disease Intervention. Science Reviews - Biology, 2024. http://dx.doi.org/10.57098/scirevs.biology.3.2.1.

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The discovery of proteolysis-targeting chimeras (PROTACs) is among the most exciting and promising avenues in cancer therapy. These fascinating compounds signify a paradigm shift from traditional approaches to medication development, offering a new idea that leverages the complexities of biological mechanisms to accomplish highly focused degradation of particular proteins implicated in pathological processes. This novel strategy has the potential to address a number of drawbacks with conventional therapy techniques, such as the development of drug resistance and unexpected adverse effects resu

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