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1

Wagner, Olaf, Julian Thiele, Marie Weinhart, et al. "Biocompatible fluorinated polyglycerols for droplet microfluidics as an alternative to PEG-based copolymer surfactants." Lab on a Chip 16, no. 1 (2016): 65–69. http://dx.doi.org/10.1039/c5lc00823a.

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Polyglycerol-based triblock surfactants with tailored side-chain composition are exemplified in cell encapsulation and in vitro gene expression studies in droplet-based microfluidics as alternative to PEG-based surfactants.
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2

Lee, Jungno. "An Investigation of the Surfactants and Preservative Ingredients used in Korean Fundamental Cosmetics from 2020-2022." Korea Industrial Technology Convergence Society 27, no. 3 (2022): 73–79. http://dx.doi.org/10.29279/jitr.2022.27.3.73.

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Surfactants and preservative ingredients have a dominant effect on the safety of cosmetics. This study investigated the main surfactants and preservative ingredients in Korean fundamental cosmetics sold within the past three years. Oil-in-water (O/W) emulsifiers have been mainly polyethylene glycol (PEG)-free surfactants; however, the main solubilizing agents have remained PEG-based. Paraben, which was the main preservative ingredient, has been replaced by 1,2-hexanediol and ethylhexylglycerin. These technical safety advances concerning surfactants and preservative ingredients have made Korean
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Hayat, Muhammad Dilawer, and Peng Cao. "Development of PEG/PMMA Based Binders for Ti-Metal Injection Moulding." Key Engineering Materials 704 (August 2016): 130–38. http://dx.doi.org/10.4028/www.scientific.net/kem.704.130.

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As the world is moving towards green manufacturing, there is an increasing demand for the use of clean and environmentally friendly binder systems in metal injection moulding (MIM) industry. One example of these developed binders is polyethylene glycol (PEG) - polymethyl methacrylate (PMMA) based system. We have systematically evaluated and optimized this binder system, and reported some interesting new results. In this article, we reported the effect of PEG molecular weight on rheological properties of the feedstock and its water debinding behaviour. We also investigated the effects of differ
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Maeda, Tomoki, Midori Kitagawa, Atsushi Hotta, and Satoshi Koizumi. "Thermo-Responsive Nanocomposite Hydrogels Based on PEG-b-PLGA Diblock Copolymer and Laponite." Polymers 11, no. 2 (2019): 250. http://dx.doi.org/10.3390/polym11020250.

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Poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PEG-b-PLGA) diblock copolymers are widely known as polymeric surfactants for biomedical applications, and exhibit high solubility in water compared to PLGA-b-PEG-b-PLGA triblock copolymers known as gelation agents. In order to overcome the difficulties in the preparation of thermo-responsive hydrogels based on PLGA-b-PEG-b-PLGA due to the low solubility in water, the fabrication of thermo-responsive hydrogels based on PEG-b-PLGA with high solubility in water was attempted by adding laponite to the PEG-b-PLGA solution. In detail, PEG-b-PLG
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Vadapalli, Ratna Sree, and Sunitha Reddy, M. "Formulation and Evaluation of Self-Micro Emulsifying Drug Delivery System (SMEDDS) of Ticagrelor." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 11 (2022): 628–43. http://dx.doi.org/10.36348/sjmps.2022.v08i11.001.

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The present work mainly emphasized on the enhancement of solubility of Ticagrelor by developing Self- Micro emulsifying drug delivery system. Ticagrelor is a BCS class IV drug with poor aqueous solubility and permeability. The saturated solubility of Ticagrelor in various oils, surfactants and co-surfactants was determined by using UV-spectroscopy. The excipients were selected based on their maximum solubility and compatibility for Ticagrelor. SMEDDS formulations od Ticagrelor were developed using different oils, surfactants and co-surfactant combinations (4:1 and 3:1). Pseudo ternary phase di
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Dairaku, Sachiko, Wataru Horie, and Yukari Sakazaki. "Developing High Performance Sunscreen Products without PEG-based Surfactants." Journal of Society of Cosmetic Chemists of Japan 50, no. 4 (2017): 314–20. http://dx.doi.org/10.5107/sccj.50.314.

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Shokuhfar, Ali, S. Alibeigi, Mohammad Reza Vaezi, and Sayed Khatiboleslam Sadrnezhaad. "Synthesis of Fe3O4 Nanoparticles Prepared by Various Surfactants and Studying their Characterizations." Defect and Diffusion Forum 273-276 (February 2008): 22–27. http://dx.doi.org/10.4028/www.scientific.net/ddf.273-276.22.

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Magnetite (Fe3O4) nanoparticles were prepared simply by the reverse co-precipitation method from the solution of ferrous/ferric mixed salt in the presence of cationic surfactant (cetyl trimethyl ammonium bromide, CTAB) and nonionic surfactant (Polyethylene glycol, PEG) in two concentrations. Meanwhile, Fe3O4 nanoparticles without surfactant are also synthesized under the same condition for comparison. In addition via the reverse co-precipitation method, the pH which is an important factor in synthesis of magnetite was controlled at high values easily. The experimental results reveal that addit
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8

Scanga, Randall, Lucie Chrastecka, Ridhwan Mohammad, Austin Meadows, Phenix-Lan Quan, and Eric Brouzes. "Correction: Click chemistry approaches to expand the repertoire of PEG-based fluorinated surfactants for droplet microfluidics." RSC Advances 9, no. 1 (2019): 255–56. http://dx.doi.org/10.1039/c8ra90097c.

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9

Zhang, Mingyu, and Guangyan Zhang. "Recent Advances in the Properties and Applications of Polyglycerol Fatty Acid Esters." Polymers 17, no. 7 (2025): 879. https://doi.org/10.3390/polym17070879.

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Although polyethylene glycol (PEG)-based surfactants are widely used in various industries due to their wide range of hydrophile–lipophile balance (HLB) values, their possible by-product, 1,4-dioxane, has been listed as a reasonably anticipated human carcinogen, which may limit their applications in fields closely related to the human body. Polyglycerol fatty acid esters (PGFEs), a class of surfactants based on polyglycerol (another polyether), also have a wide range of HLB values that can be adjust by varying the degree of polymerization of the polyglycerol, the length of the fatty acid carbo
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10

Kubiak, Adam, Zuzanna Bielan, Aleksandra Bartkowiak, et al. "Synthesis of Titanium Dioxide via Surfactant-Assisted Microwave Method for Photocatalytic and Dye-Sensitized Solar Cells Applications." Catalysts 10, no. 5 (2020): 586. http://dx.doi.org/10.3390/catal10050586.

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In this study, titania nanoparticles were obtained using the microwave-assisted technique. Moreover, different surfactants (PEG (Mn = 400), Pluronic P123 and Triton X−100) were used during the synthesis in order to determine their impact on the crystallinity and morphology of the final products. Subsequently, techniques such as XRD, SEM and TEM (performed in high contrast and high-resolution mode), diffuse reflectance spectroscopy (DRS), low temperature N2 sorption (BET model), FTIR and TGA were carried out. Based on the crystallinity analysis of the obtained materials, it was established that
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11

Alamri, Ali, Ali Alqahtani, Taha Alqahtani, et al. "Design, Physical Characterizations, and Biocompatibility of Cationic Solid Lipid Nanoparticles in HCT-116 and 16-HBE Cells: A Preliminary Study." Molecules 28, no. 4 (2023): 1711. http://dx.doi.org/10.3390/molecules28041711.

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In this study, pEGFP-LUC was used as a model plasmid and three distinct cationic lipids (dioleyloxy-propyl-trimethylammonium chloride [DOTMA], dioleoyl trimethylammonium propane [DOTAP], and cetylpyridinium chloride [CPC]) were tested along with PEG 5000, as a nonionic surfactant, to prepare glyceryl monostearate (GMS)-based cationic solid lipid nanoparticles (cSLNs). Both the type and quantity of surfactant had an impact on the physicochemical characteristics of the cSLNs. Thermal analysis of the greater part of the endothermic peaks of the cSLNs revealed they were noticeably different from t
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12

Scanga, Randall, Lucie Chrastecka, Ridhwan Mohammad, Austin Meadows, Phenix-Lan Quan, and Eric Brouzes. "Click chemistry approaches to expand the repertoire of PEG-based fluorinated surfactants for droplet microfluidics." RSC Advances 8, no. 23 (2018): 12960–74. http://dx.doi.org/10.1039/c8ra01254g.

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Federer, Christoph, Victor Claus, Nathalie Hock, Julian David Friedl, Richard Wibel, and Andreas Bernkop-Schnürch. "Charge-reversal nanoemulsions: A systematic investigation of phosphorylated PEG-based surfactants." International Journal of Pharmaceutics 613 (February 2022): 121438. http://dx.doi.org/10.1016/j.ijpharm.2021.121438.

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Patel, Swati, Prabhat Jain, and Geeta Parkhe. "FORMULATION AND EVALUATION OF ACYCLOVIR LOADED NOVEL NANO-EMULSION GEL FOR TOPICAL TREATMENT OF HERPES SIMPLEX VIRAL INFECTIONS." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 265–70. http://dx.doi.org/10.22270/jddt.v8i5-s.1968.

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Acyclovir has low bioavailability mainly due to low solubility. This study aimed to formulate an optimized acyclovir (ACV) nanoemulsion gel for the slow, variable and incomplete oral drug absorption in patient suffering from herpes simplex viral infection. The dispersion solubility of acyclovir was studied in various oils, surfactants and co-surfactants and by constructing pseudo phase ternary diagram nanoemulsion area was identified. The optimized formulations of nanoemulsions were subjected to thermodynamic stability tests. After stability study, stable formulation was characterized for drop
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15

Sampora, Yulianti, Muhammad Ihsan Sofyan, Muhammad Ghozali, et al. "A Comparative Evaluation of Solid-State Catalysts for Synthesis of Non-Ionic Surfactant Based Oleic Acid for Enhanced Oil Recovery (EOR)." Molekul 20, no. 1 (2025): 39. https://doi.org/10.20884/1.jm.2025.20.1.11077.

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Abstract. The Enhanced Oil Recovery (EOR) process with chemical techniques carried out by injecting chemicals such as surfactants, can be an alternative to increase oil production, especially in old oil wells. This study investigated the best formulation of non-ionic surfactants based on the mole ratio of oleic acid and PEG-400 as well as catalyst types such as KOH and p-TSA 1%, which are used in surfactant synthesis to be able to increase oil production. The tests carried out are the value of acid, saponification, ester, and iodine, FTIR, NMR as well as a test of compatibility, phase behavior
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16

Annisa, Rahmi, Mochammad Yuwono, and Esti Hendradi. "Formulation and characterization of Eleutherine palmifolia extract-loaded self-nanoemulsifying drug delivery system (SNEDDS)." Journal of Basic and Clinical Physiology and Pharmacology 32, no. 4 (2021): 859–65. http://dx.doi.org/10.1515/jbcpp-2020-0400.

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Abstract Objectives This study aimed to determine the effect of different components and ratios of oil, surfactant, and cosurfactant on E. palmifolia extract-loaded SNEDDS. Methods E. palmifolia extract loaded SNEDDS was formulated from virgin coconut oil, Miglyol 812 as oil, using Tween 80 and Transcutol as surfactants, as well as propylene glycol and PEG 400 as cosurfactants. The optimization design formula consisted of eight design formulas in five ratio formulas, thus a total of 40 formulas were optimized using different components and ratios of oil, surfactant, and cosurfactant. These rat
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17

Wu, M., E. Dellacherie, A. Durand, and E. Marie. "Poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion polymerization. 2. PEG-based surfactants." Colloids and Surfaces B: Biointerfaces 69, no. 1 (2009): 147–51. http://dx.doi.org/10.1016/j.colsurfb.2008.10.003.

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18

Mezei, Amalia, and Ramon Pons. "MWNTs or PEG as Stability Enhancers for DNA–Cationic Surfactant Gel Particles." International Journal of Molecular Sciences 22, no. 16 (2021): 8801. http://dx.doi.org/10.3390/ijms22168801.

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Cationic surfactants interact with DNA (Deoxyribonucleic acid), forming surfactant-DNA complexes that offer particularly efficient control for encapsulation and release of DNA from DNA gel particles. In the present work, DNA-based particles were prepared using CTAB (Cetyltrimethylammonium bromide) as the cationic surfactant and modified using two different additives: (Multi-Walled Carbon Nanotubes) MWNT or PEG (Poly Ethylene Glycol). The use of both additives to form composites increased the stability of the gel particles. The stability was monitored by the release of DNA and CTAB in different
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Jiang, Bowen, Jie Guan, Peng Zhao, Yulin Chen, and Zefang Zhang. "Effect of Polyoxyethylene-Based Nonionic Surfactants on Chemical–Mechanical Polishing Performance of Monocrystalline Silicon Wafers." Crystals 14, no. 5 (2024): 460. http://dx.doi.org/10.3390/cryst14050460.

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The use of surfactants is crucial in the chemical–mechanical polishing fluid system for silicon wafers. This paper examines the impact of the functional group structure of polyoxyethylene-based nonionic surfactants and the variation in the polyoxyethylene (EO) addition number on the polishing performance of monocrystalline silicon wafers, to achieve the appropriate material removal rate and surface quality. The results demonstrated that the straight-chain structure of fatty alcohol polyoxyethylene ether (AEO-9) exhibited superior performance in wafer polishing compared to octylphenol polyoxyet
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20

Jolly, Anju, Véronique Vitry, Golnaz Taghavi Pourian Azar, Thais Tasso Guaraldo, and Andrew J. Cobley. "Surface Defect Mitigation of Additively Manufactured Parts Using Surfactant-Mediated Electroless Nickel Coatings." Materials 17, no. 2 (2024): 406. http://dx.doi.org/10.3390/ma17020406.

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The emergence of defects during the early production phases of ferrous-alloy additively manufactured (AM) parts poses a serious threat to their versatility and adversely impacts their overall mechanical performance in industries ranging from aerospace engineering to medicine. Lack of fusion and gas entrapment during the manufacturing stages leads to increased surface roughness and porosities in the finished part. In this study, the efficacy of employing electroless nickel–boron (Ni-B) deposition to fill and level simulated AM defects was evaluated. The approach to levelling was inspired by the
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Honarvari, Banafsheh, Sara Karimifard, Niyayesh Akhtari, et al. "Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study." Molecules 27, no. 14 (2022): 4634. http://dx.doi.org/10.3390/molecules27144634.

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As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were
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Pradnyani, Putu Dhea, Lutfi Suhendra, and I. Nyoman Semadi Antara. "Karakteristik Mikroemulsi Minyak Atsiri Kulit Buah Lemon (Citrus limon) Pada Penambahan Kosurfaktan Dan Rasio Surfaktan-Kosurfaktan Dengan Minyak Atsirinya." JURNAL REKAYASA DAN MANAJEMEN AGROINDUSTRI 12, no. 4 (2025): 490. https://doi.org/10.24843/jrma.2024.v12.i04.p03.

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ABSTRACT Essential oil from lemon peel (Citrus limon) has a distinctive aroma that can be used as a body mist. Body mist is a type of perfume with an essential oil content of 3-5%. Lemon peel essential oil microemulsion is a water-based body mist product. Lemon essential oil microemulsion is formed from a mixture of surfactants (Tween 20, Tween 80 and Span 80), co-surfactant, Polyethylene Glycol (PEG) 400, lemon essential oil and water. The first stage of the research was the formation of fruit peel essential oil microemulsions by treating the mixture ratio of surfactant and co-surfactant. The
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Handoyo Sahumena, Muhamad, Suryani Suryani, and Neni Rahmadani. "Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span." Journal Syifa Sciences and Clinical Research 1, no. 2 (2019): 37–46. http://dx.doi.org/10.37311/jsscr.v1i2.2660.

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Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, sur
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Dalibera, Natália Cristina, Maria Helena Ambrosio Zanin, Kleber Lanigra Guimaraes, Leonardo Alencar de Oliveira, and Adriano Marim de Oliveira. "Optimized formulation of thermoresponsive nanoemulsion-based gel for enhanced oil recovery (EOR) application." Applied Petrochemical Research 11, no. 2 (2021): 155–63. http://dx.doi.org/10.1007/s13203-021-00269-9.

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AbstractA thermoresponsive system of a nanoemulsion-based gel with favorable characteristics to enhanced oil recovery (EOR) application is presented. A full factorial design study with different formulations of thermosensitive nanoemulsion-based gels was performed to assess the influence of the oil chain length, concentration of polyethylene glycol (PEG 400) and concentration of oil on the rheological behavior of the system. A formulation with low viscosity at room temperature and high viscosity at the temperature of the oil extraction well was presented. Hexane (6-carbon chain), capric acid (
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Sudhir, M., M. Manjusha, R. R. Manjula, N. Jyothi, and N. Lakshmi Prasanthi. "PREPARATION AND EVALUATION OF IBUPROFEN LIQUID FILL FORMULATIONS FOR SOFT GELS." INDIAN DRUGS 54, no. 12 (2017): 65–68. http://dx.doi.org/10.53879/id.54.12.10873.

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The present investigation was undertaken with an objective to prepare and evaluate liquid fill formulations of non-steroidal anti-inflammatory drug, ibuprofen (IBU), in order to improve its dissolution properties and thereby its bioavailability. Liquid fill formulations were prepared by employing different co-solvents and surfactants like polyethylene glycol 400 (PEG 400), propylene glycol (PG) and polyvinylpyrrolidone (PVP K-30). The liquid fills were characterized by assay, rheology, clarity, in vitro dissolution studies and FTIR. More than 90% of the drug was released within 5 min from PVP
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Cirri, Marzia, Francesca Maestrelli, Giovanna Corti, Paola Mura, and Maurizio Valleri. "Fast-Dissolving Tablets of Glyburide Based on Ternary Solid Dispersions with PEG 6000 and Surfactants." Drug Delivery 14, no. 4 (2007): 247–55. http://dx.doi.org/10.1080/10717540601067802.

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Park, Myung-Ju, Yong-Chan Chung, and Byoung Chul Chun. "PEG-based surfactants that show high selectivity in disrupting vesicular membrane with or without cholesterol." Colloids and Surfaces B: Biointerfaces 32, no. 1 (2003): 11–18. http://dx.doi.org/10.1016/s0927-7765(03)00100-0.

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D. V. R. N., Bhikshapathi, and Priya Keerthi. "Design and Characterization of Self-Nanoemulsifying Drug Delivery Systems of Rosuvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 2 (2018): 4042–52. http://dx.doi.org/10.37285/ijpsn.2018.11.2.6.

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Development of self-emulsifying drug delivery systems (SEDDS) are becoming more popular to improve the oral bioavailability of poorly water-soluble drugs. Rosuvastatin is a lipid-lowering agent used in patients suffering from dyslipidemia. It is a competitive inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme A, which converts mevalonate to cholesterol. Rosuvastatin is a BCS class II (poor solubility) drug; hence, SNEDDS are being formulated to enhance oral bioavailability of the drug. In the present study, rosuvastatin SNEDDS were formulated using different oils, surfactant and co-surfactant.
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Irfan, Muhammad, Mir Azam Khan, Maqsood Ur Rehman, et al. "Fabrication of Ketoconazole Nanoformulation Using Extra Virgin Olive Oil: A Comparative Pharmacokinetic and Stability Study." Inkwell Innovations in Life Sciences 1, no. 1 (2024): 1–12. https://doi.org/10.63079/iils.01.01.017.

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Ketoconazole belongs to the class II drugs of the biopharmaceutical classification system and has low solubility issues. In the market, the available drug ketoconazole is 200-400 mg and is associated with low solubility. To cope with these issues nanoemulsion is formulated. During the fabrication of the nanoemulsion, olive oil was used as a lipid, tween 80 as a surfactant, and PEG 600 as a co-surfactant. By changing these ratios of surfactants and co-surfactants, formulations with different particle sizes and polydispersity index were obtained. The optimized lipid-based nanoparticles obtained
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Putri, Salsabila Ayundiva, and Lina Winarti. "Meloxicam self-nano-emulsifying drug delivery system with surfactants combination: Formulation and in vitro release model." Pharmacy Education 23, no. 4 (2023): 71–75. http://dx.doi.org/10.46542/pe.2023.234.7175.

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Background: Meloxicam has low water solubility, which affects the dissolution and level of absorption. Objective: The study aimed to develop a self-nano-emulsifying drug delivery system (SNEDDS) based on a non-ionic surfactant combination and evaluate the release kinetics model using the DDsolver program. Methods: Oil, surfactant, and co-surfactant were selected based on the solubility of meloxicam. Results: The best formula showed that 10% of castor oil, 70% of surfactant (tween 80: chromophore RH 40 in 1:1), and 20% of PEG 400 could develop SNEDDS with the 99.84±0.04% percentage of transmitt
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Fatimi, Hana Anisa, Devi Yanthre Sari Manurung, Rizky Dwi Larasati, et al. "REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL." JIFI (Jurnal Ilmiah Farmasi Imelda) 8, no. 1 (2024): 69–77. https://doi.org/10.52943/jifarmasi.v8i1.1767.

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The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Sev
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Ascencio, Jesús J., Leticia S. Magalhães, Fabrício B. Ferreira, Otto Heinz, André Ferraz, and Anuj K. Chandel. "Surfactant-Enhanced Enzymatic Hydrolysis of Eucalyptus Kraft Pulp: The Interrelationship Between Lignin Reduction and Sugar Recovery." Catalysts 15, no. 1 (2025): 47. https://doi.org/10.3390/catal15010047.

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This study examines the effect of surfactant-enhanced enzymatic hydrolysis on eucalyptus Kraft pulps produced under high (CPHA) and mild (CPMA) alkali conditions to optimize saccharification and sugar yield. Compositional analysis revealed an increase in glucan content, from 40% in untreated eucalyptus to 70.1% in CPHA. Both pulps were hydrolyzed using Cellic® CTec3 HS enzyme (Novozymes). A 22 factorial design revealed maximum sugar conversion (~100%) with enzyme loading of 10 FPU/g carbohydrate and 10% (w/v) solids. Tween 20 significantly boosted hydrolysis in CPMA, increasing reducing sugars
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PATIL, MORESHWAR, DEVYANI CHAVAN, ROHAN BHUTADA, and VARDHMAN MURKUNDE. "LIPID BASED SOLID SELF-EMULSIFYING DELIVERY SYSTEM OF PITAVASTATIN CALCIUM: DEVELOPMENT AND CHARACTERIZATION." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 02 (2020): 214–19. http://dx.doi.org/10.25004/ijpsdr.2022.140209.

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Solid self-emulsifying delivery system containing pitavastatin calcium was developed using oil and hydrophilic surfactants. Pitavastatin calcium has low solubility and low bioavailability; hence, it was meaningful to improve solubility and dissolution properties by using suitable formulation component and process. Based on preliminary study, oleic acid, Tween 20 and PEG 400 were utilized for development of self-emulsifying system. Microemulsion region was identified by pseudo-ternary phase diagrams. The liquid system: adsorbent (Aerosil 200) at a ratio of 2:1 was employed for spray drying. The
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Ayalasomayajula, Lakshmi U., Chandra S. Patro, and Saroj K. Raul. "Selection and Characterization of a Nanoemulsion of Poorly Soluble Drug by Applying Box-Behnken Design and Converting it into a Nanoemulgel for Topical Application." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 1–10. http://dx.doi.org/10.25258/ijpqa.15.1.01.

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In the present work, nanoemulsion (NE) based hydrogel, i.e., nanoemulgel (NEG) of Itraconazole, an antifungal drug was prepared and investigated to study its potential in delivering a drug topically. NE of Itraconazole was prepared by high energy emulsification method employing anise oil as lipid phase; Gelucire 44/14 and PEG 400 are surfactant and co-surfactants, respectively. The construction of ternary phase diagrams determined the concentration of the ingredients. The prepared NE’s were thus assessed for various parameters such as pH, electric conductivity, refractive index, viscosity, spr
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Mosqueira, Vanessa Carla Furtado, Philippe Legrand, and Gillian Barratt. "Surface-Modified and Conventional Nanocapsules as Novel Formulations for Parenteral Delivery of Halofantrine." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3193–202. http://dx.doi.org/10.1166/jnn.2006.444.

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The aim of this work was to develop a stable injectable formulation of the antimalarial drug halofantrine (Hf) based on nanocapsules (NC) prepared from biodegradable polymers with Miglyol® 810N as the oily core. Poly(D,L-lactide) PLA and its copolymers with poly(ethyleneglycol) (PLA-PEG) were used together with the surfactants poloxamer 188 and lecithin to yield NC with different surface properties. Highly efficient loading of the free base form of Hf was obtained; zeta potential measurements indicated that a part of the associated Hf was at the NC surface, interacting with the lecithin. NC we
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36

Morikawa, Hiroshi, Shintaro Koike, Megumi Saiki, and Yasuo Saegusa. "Synthesis and characterization of the PEG-based nonionic surfactants endowed with carboxylic acid moiety at the hydrophobic terminal." Journal of Polymer Science Part A: Polymer Chemistry 46, no. 24 (2008): 8206–12. http://dx.doi.org/10.1002/pola.23095.

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37

Pengnam, Supusson, Samarwadee Plianwong, Kanokwan Singpanna, et al. "PEGylated Plier-Like Cationic Niosomes on Gene Delivery in HeLa Cells." Key Engineering Materials 819 (August 2019): 151–56. http://dx.doi.org/10.4028/www.scientific.net/kem.819.151.

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Lipid-based formulations have been used as a widespread carrier to improve gene delivery. Niosomes, one type of lipid-based vesicular systems are produced from non-ionic surfactants which are generally inexpensive and potentially more stable than phospholipids. This article was to develop PEGylated cationic niosomes for DNA delivery. Thin film hydration and sonication method were applied for cationic niosomes. The niosome formulations were composed of Span 20, cholesterol (Chol) and plier-like cationic lipid B (PCL-B) with or without cholesterol-polyethylene glycol 2000 (Chol-PEG). The physico
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38

Gallego, Cristina, Alba Somoza, Héctor Rodríguez, and Ana Soto. "AOT + Polyethylene Glycol Eutectics for Enhanced Oil Recovery." Applied Sciences 11, no. 17 (2021): 8164. http://dx.doi.org/10.3390/app11178164.

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Eutectic solvents are currently being proposed as useful chemicals for enhanced oil recovery (EOR). In this work, for the first time, the preparation of eutectics based on surfactants and polymers was proposed for this application. These chemicals can be tailored to offer the most desired properties for oil recovery: water/oil interfacial tension reduction and increase of the aqueous phase viscosity, while concomitantly facilitating their handling due to their liquid character at ambient conditions. Sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and polyethylene glycol (PEG) of three different m
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39

Ainurofiq, Ahmad, Yuniawan Hidayat, Eva Y. P. Lestari, Mayasri M. W. Kumalasari, and Syaiful Choiri. "Resveratrol Nanocrystal Incorporated into Mesoporous Material: Rational Design and Screening through Quality-by-Design Approach." Nanomaterials 12, no. 2 (2022): 214. http://dx.doi.org/10.3390/nano12020214.

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Bioflavonoids from grape seeds feature powerful antioxidant and immunostimulant activities, but they present problems related to solubility and bioavailability. Nanocrystal (NC) incorporated into a mesoporous carrier is a promising strategy to address these issues. However, the preparation of this formulation involves the selection of factors affecting its critical quality attributes. Hence, this study aimed to develop an NC formulation incorporating resveratrol into a soluble mesoporous carrier based on rational screening design using a systematic and continuous development process, the quali
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40

Zhou, Qu, Weigen Chen, Shudi Peng, and Wen Zeng. "Hydrothermal Synthesis and Acetylene Sensing Properties of Variety Low Dimensional Zinc Oxide Nanostructures." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/489170.

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Various morphologies of low dimensional ZnO nanostructures, including spheres, rods, sheets, and wires, were successfully synthesized using a simple and facile hydrothermal method assisted with different surfactants. Zinc acetate dihydrate was chosen as the precursors of ZnO nanostructures. We found that polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), glycine, and ethylene glycol (EG) play critical roles in the morphologies and microstructures of the synthesized nanostructures, and a series of possible growth processes were discussed in detail. Gas sensors were fabricated using screen-p
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41

Shrishail M Ghurghure, Priya L. Ingale, Anup A. Dhange, Akshay S Javalgikar, Rudramuni H Kore, and Dadagouda M Birajdar. "Itraconazole Self-Nano Emusifying Drug Delivery System for Enhancement of Solubility." Journal of Advanced Zoology 44, no. 5 (2023): 150–55. http://dx.doi.org/10.17762/jaz.v44i5.2577.

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The main objective of formulation is to enhance the bioavailability of the drug within the body. Some of the challenging subjects associated with poorly water-soluble drugs concern solubility and bioavailability factors. To overcome these problems, new technologies, such as lipid-based drug delivery systems including micro or nano emulsifying drug delivery system, have obtained importance in recent years, due to their enhanced solubility and bioavailability in the gastrointestinal tract. Such systems are solubilized within the lipid excipients or mixed with oils or surfactants/co-solvents to f
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42

Shah, Muhammad Khurshid Alam, Abul Kalam Azad, Asif Nawaz, et al. "Formulation Development, Characterization and Antifungal Evaluation of Chitosan NPs for Topical Delivery of Voriconazole In Vitro and Ex Vivo." Polymers 14, no. 1 (2021): 135. http://dx.doi.org/10.3390/polym14010135.

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This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-drying technique. The effect of surfactants and polymers on the physicochemical properties, in vitro release, and permeation of NPs was investigated. The prepared NPs containing various surfactants and polymers (e.g., Tween 20 (T20), Tween 80 (T80), sodium lauryl sulfate (SLS), propylene glycol (PG), and Polyethylene glycol-4000 (PEG-4000)) were physiochemically evaluated for size, zeta potential, drug content, percent entrapment efficiency, in vitro release, and permeation across rats’ skin. A Franz diffusi
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43

Dewan, Irin, Ananta Saha, SM Ashraful Islam, Mahjabeen Gazi, Tasnuva Amin, and Sayeeda Fahmee Chowdhury. "Study and Evaluation of Release Kinetics of Tramadol HCl from Lipid Based Sustained Release Capsules by Melt Matrix." Dhaka University Journal of Pharmaceutical Sciences 11, no. 2 (2013): 137–45. http://dx.doi.org/10.3329/dujps.v11i2.14572.

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The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were prepared by melt-matrix method and were filled in hard gelatin capsule shell (size 0). In this experiment, a mixture of Glycerol monostearate (GMS) and lipid materials like different lipophilic oils and surfactants were used to improve the matrix int
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44

Andersen, F. Alan. "Final Report on the Safety Assessment of Ceteareth-2, -3, -4, -5, -6, -7, -8, -9, -10, -11, -12, -13, -14, -15, -16, -17, -18,-20,-22,-23,-24,-25,-27, -28, -29, -30, -33, -34, -40, -50, -55, -60, -80, and -100." International Journal of Toxicology 18, no. 3_suppl (1999): 41–49. http://dx.doi.org/10.1177/109158189901800306.

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Ceteareths, used in a large number of cosmetics as surfactants, are the polyethylene glycol (PEG) ethers of Cetearyl Alcohol (q,v.). To supplement the limited available data on Ceteareths, previous findings from the safety assessment of Polyethylene Glycol (PEG), several fatty alcohols (Cetearyl Alcohol, Cetyl Alcohol, and Stearyl Alcohol), and Steareths were considered. These data indicate little evidence of toxicity. Although various metabolites of monoalkyl ethers of ethylene glycol are reproductive and developmental toxins, given the methods of manufacture of Ceteareth compounds, there is
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45

Tayal, Shivam, Akash Sharma, and Abhay Kumar. "Development and Characterization of Non-Aqueous based Self Emulsifying Nano Emulsion of Curcumin." Middle East Journal of Applied Science & Technology 06, no. 02 (2023): 144–52. http://dx.doi.org/10.46431/mejast.2023.6216.

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This research presented a novel as well as an easy method for a non-aqueous based self-emulsifying nanoemulsion of hydrophobic drug. In this Non Aqueous based self nanoemulsifying drug delivery system (SNEDDS) of curcumin was prepared, and in vitro Analysis was done. Oleic acid serves as the oil phase in Curcumin SENE formulations, which also contain Tween 20. PEG 400 as co-surfactants was selected. The preliminary confirmation was done by FTIR spectra and 1603.80cm -1 [C=C], 3420.87 cm -1 [polymeric OH stretching], 1377.22 cm -1 [C=O stretching] was observed. The preformulation study was also
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46

Lee, Jong-Hwa, and Gye-Won Lee. "Formulation Approaches for Improving the Dissolution Behavior and Bioavailability of Tolvaptan Using SMEDDS." Pharmaceutics 14, no. 2 (2022): 415. http://dx.doi.org/10.3390/pharmaceutics14020415.

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Tolvaptan, a selective vasopressin receptor antagonist, is a Class IV agent of Biopharmaceutical Classification System (BCS). To improve bioavailability after oral administration, the new tolvaptan-loaded self-microemulsifying drug delivery system (SMEDDS) was further optimized using a “design of the experiment (DoE)” including components of D-optional mixture design. Based on a solubility study of tolvaptan in various oils, surfactants, and cosurfactants, Capryol® 90, Tween 20, and Transcutol® HP [or polyethylene glycol 200 (PEG 200)] were finally selected for optimization of tolvaptan-loaded
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47

Magina, Sandra, Ana Barros-Timmons, and Dmitry V. Evtuguin. "Synthesis of Lignosulfonate-Based Dispersants for Application in Concrete Formulations." Materials 14, no. 23 (2021): 7388. http://dx.doi.org/10.3390/ma14237388.

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Lignosulfonates (LS) are products from the sulfite pulping process that could be applied as renewable environmentally-friendly polymeric surfactants. Being widely used as plasticizers and water-reducing admixtures in concrete formulations LS compete in the market with petroleum-based superplasticizers, such as naphthalene sulfonate formaldehyde polycondensate (NSF) and copolymer polycarboxylate ethers (PCE). In this work, different chemical modification strategies were used to improve LS performance as dispersants for concrete formulations. One strategy consisted in increasing the molecular we
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48

Jeong, Da In, Sungyun Kim, Ja Seong Koo, et al. "Manganese Sulfate Nanocomposites Fabricated by Hot-Melt Extrusion for Chemodynamic Therapy of Colorectal Cancer." Pharmaceutics 15, no. 7 (2023): 1831. http://dx.doi.org/10.3390/pharmaceutics15071831.

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The development of metal salts-based nanocomposites is highly desired for the Fenton or Fenton-like reaction-based chemodynamic therapy of cancer. Manganese sulfate (MnSO4)-dispersed nanoparticles (NPs) were fabricated with a hot-melt extrusion (HME) system for the chemodynamic therapy of colorectal cancer in this study. MnSO4 was homogeneously distributed in polyethylene glycol (PEG) 6000 (as a hydrophilic polymer) with the aid of surfactants (Span 80 and Tween 80) by HME processing. Nano-size distribution was achieved after dispersing the pulverized extrudate of MnSO4-based composite in the
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Morinaga, Hisatoyo, Bungo Ochiai, Hideharu Mori, and Takeshi Endo. "Synthesis and characterization of block copolymers by metal- and solvent-free ring-opening polymerization of cyclic carbonates initiated from PEG-based surfactants." Journal of Polymer Science Part A: Polymer Chemistry 44, no. 6 (2006): 1985–96. http://dx.doi.org/10.1002/pola.21306.

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Cao, Mingzhuo, Yuan Wang, Heyun Jing, et al. "Development of an Oral Isoliquiritigenin Self-Nano-Emulsifying Drug Delivery System (ILQ-SNEDDS) for Effective Treatment of Eosinophilic Esophagitis Induced by Food Allergy." Pharmaceuticals 15, no. 12 (2022): 1587. http://dx.doi.org/10.3390/ph15121587.

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Isoliquiritigenin (ILQ) is a natural flavonoid with various pharmacological activities. In this study, we optimized the preparation method of self-nano-emulsion-loaded ILQ to further improve its bioavailability based on our previous study. In addition, its effect on the treatment of eosinophilic esophagitis was also evaluated. Combined surfactants and co-surfactants were screened, and the optimal formulation of ILQ-SNEDDS was determined according to droplet size, droplet dispersity index (DDI), and drug loading. The formulation was composed of ethyl oleate (oil phase), Tween 80 & Cremophor
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