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Rozprawy doktorskie na temat „Peptides Synthesis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Chen, Fei, and 陳飛. "Studies on aminoxy peptides and prebiotic peptide formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38534149.

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2

Puchelle, Valentin. "Peptide-polymer conjugates : divergent synthesis from the initiating peptides." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS472.

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L’utilisation de peptides pour des applications biomédicales reste limitée, en raison de leur courte demi-vie biologique. Le greffage de polymères aux peptides a conduit à l’amélioration des propriétés du peptide. Les conjugués peptide-polymère peuvent être synthétisés par méthode convergente ou divergente. Alors que la première approche conduit à de faibles rendements, la deuxième est limitée à la polymérisation de monomères vinyliques. Nous proposons une méthode de synthèse divergente des conjugués, basée sur la fonctionnalisation des liaisons peptidiques, via le greffage de polyéthers. En e

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3

Swenson, Helen Rachel. "Studies in synthetic peptides and heterocyclic synthesis." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13061.

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The following work documents three studies undertaken using solid phase synthesis techniques. Interaction of the zinc metalloprotease, endothelin converting enzyme-1(ECE-1), with its peptidic natural substrate big endothelum-1 has been investigated via an SAR study, using solid phase peptide synthesis (SPPS). Truncated forms of the substrate had been previously reported to inhibit ECE-1, this was confirmed however the big ET-1 analogues were shown to be substrates for the enzyme. A short study of the substrate specificity of ECE-1 was carried out. The synthesis of vast libraries of peptides us

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4

Dillon, David Lawrence. "Peptide derivatives as pharmaceuticals : synthesis and reactions of n-thioacyl peptides." Thesis, Oxford Brookes University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327912.

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5

Lam, Hiu-yung, and 林曉勇. "Total synthesis of daptomycin and other cyclic peptides via Ser/Thr ligation-mediated peptide cyclization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207198.

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Head-to-tail cyclic peptides with a wide range of ring sizes have been discovered in various organisms including bacteria, fungi, plants and animals. Many of them exhibit remarkable biological activities with high potency. Daptomycin, a cyclic lipodepsipeptide isolated from soil bacteria Stretomyces roseoporus, is the first natural product antibiotic launched in a generation. Daptomycin has potent bactericidal activity against otherwise antibiotic-resistant Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and vancomyci

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6

Corrihons, Fabien. "Solid phase peptide synthesis of cyclic peptides for cancer oncology." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424312.

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7

Ndung'u, Susan Wanjiru. "The medicinal chemistry of cyclo(D-Phe-2Cl-Pro) and cyclo(Phe-4F-Pro)." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/7083.

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Although peptides and proteins are considered as lead compounds for the discovery and development of new therapeutic agents, poor metabolic and physical properties have limited their optimisation as drug candidates (Adessi & Soto, 2002). Research by medicinal chemists however, generated the discovery of structural similarities between some peptides and diketopiperazines and the common occurrence of such compounds in natural products. This discovery initiated the synthesis of diketopiperazines from amino acids in an attempt to bypass the previously mentioned limitations of using peptides as dru

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8

Sieber, Stephan Axel. "Nonribosomal peptide synthetases quaternary structure and chemoenzymatic synthesis of macrocyclic peptides /." [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0218/.

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9

Irving, Stephen L. "Synthesis and purification of peptides." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/28282.

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Improved routes to tetrabenz[<I>a,c,g,i</I>]fluorene derivatives have been developed, allowing the synthesis of N<SUP>α</SUP>-17-tetrabenzo[<I>a,c,g,i</I>]fluorenyl-methoxycarbonyl (tbfmoc) urethane derivatives of alanine, leucine, isoleucine, methionine and valine. The chloroformate and pentafluorophenyl carbonate of 17-tetrabenzo[<I>a,c,g,</I>]fluorenylmethanol have been prepared and used to introduce the base-labile Tbrmoc group onto the N<SUP>α</SUP>-termini of resin-bound peptides. The high affinity of the Tbrmoc group for porous graphitised carbon (PGC) has been exploited for the purific

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10

Alexander, Mcmanamara Linda Mary. "Synthesis of stable - helical peptides." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398920.

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11

Martari, Marco. "Structure-function relationships of bolaamphiphilic peptides and peptide hybrids." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/582.

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12

Rutt, Jason E. "The synthesis of marine cyclic peptides." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262984.

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13

Tyszka, Joanna Helen Margaret. "Towards the synthesis of polycyclic peptides." Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282302.

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14

Bennett, Fiona Catherine. "Design and synthesis of model peptides." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299882.

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15

Ahadi, Sara. "Ribosomal Synthesis of N-methylated peptides." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/134.

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Natural peptide products isolated from various organisms often contain N-methylated backbones. Such a modification of backbone of the peptide changes its conformational rigidity. This modification improves the biological properties of the peptide, such as improved target affinity, proteolytic stability or membrane permeability. Therefore synthesis of N-methylated peptide libraries is valuable in screening for drug-like peptides suitable for therapeutic uses. Protein synthesis using recombinant elements (PURE) and Flexizyme were used in order to reassign specific codons to N-methyl amino acid

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16

Hone, Neal. "The synthesis of atypical amino acids and peptides utilizing solid phase peptide synthesis and novel amine protection." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357925.

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17

Taylor, Tammye L. "UV photochemistry of synthetic model peptides." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/26966.

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18

Lobo, Ruiz Ariadna. "Pushing peptides further: Novel methodologies for the synthesis of backbone-modified peptides." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667017.

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Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic properties and their attractive pharmacological profile, they have emerged as potential tools for drug discovery. However, in vivo instability due to protease degradation and poor bioavailability are the main drawbacks that have hampered their exploitation as therapeutic agents. Of special interest are peptide-based molecules displaying peptide backbone modifications, since they often result in

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19

Allen, William M. "Synthesis and characterization of novel phosphonopeptides /." Connect to online version, 1997. http://hdl.handle.net/1989/3742.

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20

Stewart, A. S. J. "Organometallic derivatives of amino acids and peptides." Thesis, Robert Gordon University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376684.

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21

Deshmukh, Manjeet Vinayakrao. "Synthesis and characterization of mussel adhesive peptides." [S.l. : s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0111/.

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22

Brown, Angus R. "Solid phase synthesis of peptides and proteins." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/27313.

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A strategy for the total chemical synthesis and purification of proteins has been investigated and applied to the 85 residue methylated DNA binding domain (MBD) from the chromosomal protein MeCP2, the 66 residue Restriction Alleviation (Ral) protein from bacteriophage λ and the 76 residue β-chemokine Monocyte Chemotactic protein (MCP-1). The hydrophobicity of the N<SUP>α</SUP> protecting group tetrabenzo[a,c,g,i]fluorenyl-17-methoxycabonyl (Tbfmoc) has been exploited to simplify the rapid purification of the 85 amino acid MBD protein by Hplc. Initial structural studies on the synthetic protein

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23

Cutts, Rosalind Jennifer. "Modelling, NMR and synthesis of food peptides." Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/842985/.

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The work in this thesis can be divided into two sections, namely the study of delicious peptide, a food flavour and the antimicrobial peptide lactofenicin B. The main interest in these compounds is in terms of structure and conformation adopted in solution and how this relates to their mode of action. Delicious peptide was studied initially by 1H NMR spectroscopy for evidence of a specific solution structure. Results show that delicious peptide does not adopt a regular conformation in solution. Molecular dynamics simulations of this peptide show the flexibility of the peptide structure in solu

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24

Andrews, Martin James Inglis. "Design and synthesis of conformationally stabilised peptides." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264663.

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25

Zambrano, Raúl Horacio. "Synthesis and structural studies of prion peptides." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36652.

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26

Jiang, Lu. "Chemical synthesis of peptides with biological importance." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/12302.

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27

Al-Wafi, Haider. "Synthesis and biological studies of cyclic peptides." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114900/.

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Bax peptide 1c (FLIMGWTLD) and two of its derivatives, 15-mer cyclic peptide 2c (FLRELIRTIMGWTLD), 13-mer cyclic peptide 3c (FLKSSKIMGWTLD) with their linear counterparts (1b, 2b, 3b) were prepared by a head−to−tail cyclisation strategy, purified (HPLC), characterised and identified (LCMS). Then the mass and concentration of the two derivatives (2c, 3c) with their linear counterparts (2b, 3b) were calculated. MS2 mass spectra were used as evidence of synthesis of the cyclic peptides from their linear counterparts. There was a clear difference between each of the two cyclic peptides and its lin

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28

Fletcher, Matthew David. "Tailored peptides : the synthesis and conformational behaviour of partially modified retro-inverso peptides." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760695.

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29

Kumari, P. "New methods for the conjugation of peptides." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279720.

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30

Wong, Kim Kai Wai. "Synthesis of silicon functionalised cyclic peptides for enantiomeric separations." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278284.

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31

Findlay, Brandon. "Design and synthesis of cationic amphiphiles." American Society for Microbiology, 2010. http://hdl.handle.net/1993/21708.

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Cationic antimicrobial peptides (CAMPs) are produced by plants, animals and bacteria to protect their host against antagonistic microbes. The antitheses of selective antibiotics, these peptides are drawn by electrostatic and hydrophobic interactions to targets as diverse as the bacterial membrane, nucleic acids and serum proteins. This lack of specificity is their greatest strength, as mutations to single genes rarely lead to bacterial resistance. Resistance may be conferred by large scale alterations in cell envelope composition, which generally reduces bacterial fitness in the absence of

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32

Shi, Feng, and 石峰. "Synthesis, characterization and application of constrained 7/8 helix." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44363229.

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In this thesis, constrained 7/8 helix has been developed to enhance the stability of 7/8 helical structure in polar and aqueous solvents for biological application. The synthesis of constrained 7/8 helical peptides has been achieved in two steps. In the first step, a 7/8 helical peptide chain comprising alternating α-L-amino acids and α-D-aminoxy acids was assembled by standard solution phase peptide synthesis protocol. In the second step, a covalent cross-linker as the conformational constraint was incorporated into 7/8 helical peptide at adjacent α-amino acid residues by consecutive intr

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33

Freeman, David J. "Synthetic and metal binding studies of cyclic peptides." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299566.

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34

Varedian, Miranda. "Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9345.

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The secondary structure of peptides is of pivotal importance for their biological function. The introduction of photoswitchable moieties into the backbones of peptides provides a unique way of regulating their conformation using an external stimulus, i.e., light. This thesis addresses the design, synthesis, and conformational analysis of photoswitchable peptidomimetics (PSPM). Examples of photomodulation of their functional properties are given. PSPM were prepared by incorporation of stilbene and thioaurone chromophores (switches) into dipeptides. Synthetic schemes for preparing these chromoph

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35

Tegazzini, Diana. "Design, synthesis and activity evaluation of antioxidant peptides." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603073.

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Reactive Oxygen Species (ROS) produced during normal aerobic metabolism, if not promptly removed by the detoxification mechanisms of the cells, can easily react with cell components, especially lipids, producing secondary cytotoxic molecules called reactive carbonyl species (RCSs). RCSs exhibit significant chemical reactivity and can cause protein modification and dysfunction. One of the most important ReSs is 4-hydroxinonenal (HNE), an unsaturated aldehyde that has been strongly linked to Alzheimer'S disease (AD). A new series of dipeptide histidyl hydrazide analogues of carnosine was prepare

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36

Cammish, Linda E. "The solid phase synthesis of arginine containing peptides." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328560.

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37

Roach, Peter L. "Synthesis of peptides by the solid phase method." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14289.

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An investigation into the use of a novel N<SUP>PROB*LEM</SUP> protecting group in peptide synthesis is described. The protecting group, 2,2-<i>bis</i>(4'-nitrophenyl)ethoxycarbonyl (Bnpeoc), has been introduced into the full range of amino acids, including those requiring appropriate side chain protection. The Bnpeoc amino acid derivatives have been successfully applied to the solid phase synthesis of a number of peptides from ubiquitin. In addition, the peptides were assembled using a wide range of coupling reagents and conditions. The chemical syntheses of phage λ Cro protein and peptides fr

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38

Lear, Sam. "Total synthesis of bioactive peptides and whole proteins." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11946/.

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Total chemical synthesis is an essential tool for the validation of natural product structures and the discovery and elaboration of novel therapeutic scaffolds. Chapter 1 (Part I) surveys existing treatments for trypanosomatid neglected tropical diseases, and the synthesis of a novel class of antiparasitic cyclic depsipeptides is reported (Chapter 2) alongside a full NMR assignment and structure calculation using NMR-derived distance restraints. The synthetic peptides exhibit activity profiles in agreement with published results, and a series of ester-to-amide substitution analogues also synth

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39

Tamura, Takashi. "Synthesis and Biochemical Function of Selenocysteine-containing Peptides." Kyoto University, 1993. http://hdl.handle.net/2433/168917.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第5495号<br>農博第775号<br>新制||農||660(附属図書館)<br>学位論文||H5||N2607(農学部図書室)<br>UT51-93-R23<br>京都大学大学院農学研究科農芸化学専攻<br>(主査)教授左右田健次, 教授浅田浩二, 教授清水昌<br>学位規則第4条第1項該当

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40

Foster, Michael Scott. "Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31816.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Dr. Sheldon W. May; Committee Member: Dr. James C. Powers; Committee Member: Dr. Nicholas Hud; Committee Member: Dr. Niren Murthy; Committee Member: Dr. Stanley H. Pollock. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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41

Nowak, Cheryl L. "Design, synthesis, and evaluation of bicyclic peptides as ammonium ionophores." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-180827/.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: solution 13C-NMR study; olid phase peptide synthesis; bicyclic peptides; ammonium ionophores; valinomycin; ion selective electrode. Includes bibliographical references (p. 63-65).

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42

Sasubilli, Ramakrishna Gutheil William G. "Solid-phase synthesis of peptides and peptide mimetics using urethane and backbone amide linker strategies." Diss., UMK access, 2006.

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Thesis (M.S.)--School of Pharmacy. University of Missouri--Kansas City, 2006.<br>"A thesis in pharmaceutical sciences." Typescript. Advisor: William G. Gutheil. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 9, 2007. Includes bibliographical references (leaves 63-73). Online version of the print edition.

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43

Umeobika, Ugochukwu Christian. "Solid phase peptide synthesis of substrates for the chemoenzymatic generation of cyanobactins analogues." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233678.

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Ribosomal synthesized and post translational modified peptide natural products have attracted a lot of interest in the past decade. Backbone cyclization of the translated linear peptides is generally catalysed by specific enzymes giving them peptidase resistance, thermodynamic stability and various other physiological activities. These features have made backbone cyclic peptide to become an attractive resource for drug discovery. Here, we described the synthesis of linear peptides containing natural and unnatural residues and its biosynthetic mechanism to generate man-made cyclic peptides. In

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44

Hao, Yu, and 郝宇. "Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36363236.

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45

Cassidy, Peter Joseph. "The design and synthesis of peptide turn mimetics /." St. Lucia, Qld, 1998. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16396.pdf.

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46

Ng, Choi I.-teng Montserrat. "Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/380739.

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The incorporation of unsymmetrical biaryl systems into peptide sequences is a strategy that can improve their biological activity. Due to the difficulty of arylating the 4(5}-position of the imidazole ring, this doctoral thesis was focused on the development of efficient methodologies for the solid-phase synthesis of 5-arylhistidine-containing antimicrobial undecapeptides through a Suzuki-Miyaura reaction under microwave irradiation. The extension of this protocol allowed the preparation of biaryl cyclic peptides of different ring sizes bearing a His-Phe or His-Tyr biaryl linkage. Then, it was

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47

Zerkout, Saïd. "Synthèse d'hydrazino peptides." Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL052N.

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La modification de la liaison amide dans les peptides a plusieurs conséquences potentielles: une biodégradabilité réduite, une possible modulation structurale due aux perturbations du réseau de liaisons hydrogène, et éventuellement, une bio-activité modulée pour l'analogue pseudopeptidique résultant, sans nécessiter de changer les chaines latérales. Nous avons étudie les perturbations structurales induites par la substitution d'une liaison amide par un groupe hydrazide dans diverses séquences mono-, di- et tripeptidiques protégées à leurs deux extrémités par une fonction amide, et contenant l'

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48

Groussier, Marianne Francoise Andree. "A new orthogonal protecting-group strategy for lanthionine-containing peptides." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325663.

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49

Pavlov, Nikola. "Synthèse asymétrique d’analogues de β2-tryptophane et application en synthèse peptidique". Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20186/document.

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Le tryptophane est un acide aminé essentiel qui, en plus de son rôle dans la biosynthèse des protéines, est le précurseur biochimique de nombreux composés. Beaucoup de peptides biologiquement actifs, qui possèdent dans leurs séquences cet acide aminé contenant un substituant indole, ont des propriétés physiologiques importantes. On peut citer par exemple des dérivés comme la sérotonine, le tryptamine, le sumatriptan qui ont des effets neurophysiologiques. Les analogues de tryptophane sont aussi des « building block » important pour la synthèse de peptidomimétiques, d'analogues de produits natu

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50

Pahlke, Denis. "Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0003-C180-1.

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