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Rozprawy doktorskie na temat „PH regulation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Stephen, John R. "pH regulation in enteric bacteria." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=130919.

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<I>Escherichia coli</I> mutants impaired in growth and survival at low external pH in minimal medium were selected and attempts made to identify the disrupted genes. This study suggested that <I>clpX</I>, encoding a heat-shock induced protease and molecular chaperone, was functional in survival of <I>E. coli </I>at pH 3.3. Promoter probe plasmid libraries of <I>Salmonella typhimurium </I>LT2 DNA were created in <I>E. coli </I>and screened for acid-inducible transcriptional elements, and transcriptionally active fragments of degradative amino-acid decarboxylase genes recovered. Chromosomal gene

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2

Witzel, Dirk. "Pharmakologische Beeinflussung der pH-Regulation kardialer Fibroblasten." [S.l.] : [s.n.], 2003. http://archiv.ub.uni-marburg.de/diss/z2003/0424/.

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3

Rudnicka, Joanna Dorota. "Aspects of pH regulation in Aspergillus nidulans." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415560.

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4

Huertas, Tatiana Munera. "Aspects of pH regulation in Aspergillus nidulans." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526381.

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5

Rivinoja, A. (Antti). "Golgi pH and glycosylation." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292699.

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Abstract Glycans, as a part of glycoproteins, glycolipids and other glycoconjugates, are involved in many vital intra- and inter-cellular tasks, such as protein folding and sorting, protein quality control, vesicular trafficking, cell signalling, immunological defence, cell motility and adhesion. Therefore, their correct construction is crucial for the normal functioning of eukaryotic cells and organisms they form. Most cellular glycans are constructed in the Golgi, and abnormalities in their structure may derive, for instance, from alkalinization of the Golgi lumen. In this work we show th

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6

Furimsky, Marosh. "Intracellular pH regulation in hepatocytes of teleost fish." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58273.pdf.

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7

Grace, Andrew Ashley. "The regulation of intracellular pH and cardiac contraction." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319389.

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8

Taylor, Caroline Joanne. "Intracellular pH regulation in rat brain endothelial cells." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616055.

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9

Lundin, Karl, and Oscar Olli. "Automated hydroponics greenhouse : Regulation of pH and nutrients." Thesis, KTH, Maskinkonstruktion (Inst.), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-226662.

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The purpose of this project is to create a fully automatedgreenhouse that can produce year-round crops, using sensorsand actuators. Temperature in both water and air,relative humidity, water level, nutrient level and pH are allmeasured with different sensors. Though only water level,pH and nutrients will be regulated. The greenhouse will berelying on a hydroponic growing technique, meaning thatthe growing is soil-less and will be done in water. Thismakes measuring and controlling said levels easier and alsominimizes water waste and makes for a more environmentalsystem. The main focus of this p

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10

Müller, Matthias. "pH-Regulation und Glukosestoffwechsel - Wirkung von Glut1-Überexpression, Serum und Dexamethason auf den zytosolischen pH." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10733068.

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11

Warner, Christian. "Die pH-Wert-Regulation in kultivierten MCF-7-Mammakarzinomzellen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967457246.

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12

Shartau, Ryan Brady. "Vertebrate preferential intracellular pH regulation during severe acute hypercarbia." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63848.

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Environmental CO2 tensions reach >8 kPa (ca. 79,000 μatm; hypercarbia) in some habitats and create severe acid-base challenges for vertebrates. Typically, during a hypercarbic-induced respiratory acidosis, changes in blood pH are compensated for, which returns pH to its normal value, and this is coupled to tissue pH (pHi) regulation. However, during acute environmental CO₂ exposure, this process may be limited to <2 kPa PCO₂. Some fishes fully protect tissue pH (pHi) (preferential pHi regulation) despite large sustained reductions of pHe (>1 pH unit) and can tolerate PCO₂ >3 kPa. I hypothesize

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13

Sarkar, Sovan. "Aspects of pH regulation in the fungus Aspergillus nidulans." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321614.

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14

Chen, Jeng-Haur. "The molecular mechanisms of CFTR regulation by intracellular pH." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422608.

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15

Nicola, Pieris Andrew. "Regulation of intracellular pH in rat brain endothelial cells." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612803.

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16

Schewe, Bettina. "Räumliche und zeitliche Aspekte der intrazellulären pH-Regulation in Epithelien." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/2687/.

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Die Speicheldrüsen der Schmeißfliege Calliphora vicina produzieren bei Stimulierung mit dem Neurohormon Serotonin (5-Hydroxytryptamine, 5-HT) einen KCl-reichen Primärspeichel. Der transepitheliale K+-Transport wird durch eine apikal lokalisierte vakuoläre H+-ATPase (V-ATPase) energetisiert. Stimulierung der Speicheldrüsen mit 5-HT aktiviert die apikale V-ATPase, die Protonen aus der Zelle in das Drüsenlumen transportiert. Trotz des auswärts gerichteten Protonentransportes führt die 5-HT-Stimulierung kurioserweise zu einer intrazellulären Ansäuerung. Die Ursachen dieser 5-HT-induzierten Ansäuer

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17

Hasselblatt, Peter Werner. "Die pH-Regulation isoliert in-vitro-perfundierter Kolonkrypten der Ratte." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961011122.

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18

Turk, Boris. "Papain-like cysteine proteinases : regulation by proteinase inhibitors and pH /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1996. http://epsilon.slu.se/avh/1996/91-576-5227-9.gif.

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19

Maddox, Angela D. M. "Mechanisms of intracellular pH regulation in ciliated tracheal epithelial cells." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU112227.

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Regulation of intracellular pH (pH<sub>i</sub>) was studied in ciliated epithelial cells isolated from sheep tracheae. Microspectrofluorimetry of the pH -sensitive dye 2'; 7' - biscarboxyethyl -5(6) -carboxyfluorescein (BCECF) was used to measure pH<sub>i</sub> in single cells plated on coverslips and mounted in a temperature regulated superfusion chamber on a microscope stage. In both HCO<sub>3</sub><sup>-</sup>containing and HCO<sub>3</sub><sup>-</sup> -free conditions, pH<sub>i</sub> was ~ 7.20 and buffering capacity was found to be inversely related to pH<sub>i</sub>. Recovery from an acid

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20

Milner, Peter Ian. "Physiology and pathology of intracellular pH regulation in equine articular chondrocytes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614332.

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21

Meyer, Johanna Charlotte [Verfasser]. "Regulation of µ-opioid receptor function by pH / Johanna Charlotte Meyer." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1215099681/34.

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22

Meehan, James. "Inhibition of pH regulation as a therapeutic strategy in breast cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28875.

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The abnormal regulation of H+ ions, leading to a reversed pH gradient in cancer cells when compared to normal cells, is considered to be one of the most distinctive features of cancer. However, this characteristic has yet to be fully exploited as a therapeutic target in cancer. This project assessed whether targeting pH regulating proteins, which permit cancer cells to survive in the hostile hypoxic and acidic tumour microenvironment, could produce an effective therapeutic response in breast cancer. The pH regulating proteins carbonic anhydrase IX (CAIX), Na+/H+ exchanger 1 (NHE1) and vacuolar

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23

Siyanov, Violetta. "Intracellular pH Regulation by Sodium-Hydrogen Exchanger Isoforms in Preimplantation Mouse Embryos." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32251.

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Intracellular pH (pHi) impacts many cellular mechanisms including cellular metabolism, gene expression, cell volume regulation, cell survival and proliferation. Most cells use two general pHi regulatory mechanisms: HCO3-/Cl- antiporters (AE, Slc4a family) to reduce internal alkaline load, and Na+/H+ exchangers (NHE, Slc9a family) that protect cells from acidosis. Previous studies with preimplantation (PI) embryos have shown robust activity of HCO3-/Cl- exchanger in all stages of development. It was also determined that inhibition of this exchange with the stilbene AE inhibitor 4,4’-diisothiocy

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24

Arai, Fumihito, Naoya Inoue, and Hisataka Maruyama. "Optical pH Regulation Using Photochromic Material for Selective Cell Injection of Nanosensors." IEEE, 2010. http://hdl.handle.net/2237/14476.

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25

Abohamed, Abdulrahman. "Regulation of TASK-2, a pH-sensitive, two pore domain potassium channel." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421414.

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26

Paradise, Ranjani Krishnan. "Chemomechanical regulation of integrin activation and cellular processes in acidic extracellular pH." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/75840.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references (p. 162-176).<br>It is well established that extracellular pH (pHe) becomes acidic in several important physiological and pathological contexts, including the tumor and wound microenvironments. Although it is known that acidic pHe can have profound effects

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27

Stewart, Andrew Kenneth. "Intracellular pH regulation associated with proton-coupled dipeptide transport in mouse small intestine." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298321.

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28

Williams, Mark R. "pH and calcium regulation in the lens epithelial cells : a fluorimetric dye study." Thesis, University of East Anglia, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334394.

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29

Millard, Alisha Jane. "A proteomics based approach to the analysis of pH regulation in Aspergillus nidulans." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442034.

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30

Martinez-Zaguilan, Raul. "The role of intracellular pH and calcium in the regulation of cellular functions." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185889.

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Upon cell stimulation with hormones and other mitogens, a variety of biochemical and physiological responses occur within the first few minutes, including turnover of inositol phospholipids, activation of a number of kinases, and changes in intracellular pH (pHⁱⁿ) and calcium ([Ca²⁺]ⁱⁿ). Changes in both pHⁱⁿ and [Ca²⁺](in) are prominent and play a major role in the signal transduction mechanism leading to the physiological response, i.e. secretion, neurotransmission, proliferation and differentiation. The intracellular pH changes that follow mitogenic activation are complex and may reflect sev

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31

Arai, Fumihito, Tatsuro Takahata, Ayae Honda, Naoya Inoue, Taisuke Masuda, and Hisataka Maruyama. "Optical pH Regulation Using Functional Nanotool Impregnating with Photo-Responsive Chemical for Intracellular Measurement." IEEE, 2010. http://hdl.handle.net/2237/14484.

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32

ASTARIE, CATHERINE. "Contribution a l'etude du ph intracellulaire, sa regulation et ses anomalies dans l'hypertension arterielle." Paris 6, 1990. http://www.theses.fr/1990PA066021.

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Le ph cytosolique (phc) en modulant l'activite metabolique des cellules et en participant aux mecanismes de proliferation et de croissance cellulaires, pourrait jouer un role dans l'hypertension arterielle. Dans la plaquette sanguine humaine non stimulee ex vivo, nous avons montre par l'indicateur fluorescent de ph, bcecf, que l'homeostasie du phc est controlee par le gradient transmembranaire de na#+, independamment de l'echangeur na#+/h#+ et des transporteurs de hco#3# et par des mouvements intracellulaires de ca#2#+. Lors d'une acidification intracellulaire, l'echange na#+/h#+ caracterise p

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33

GRENIER, AMY. "REGULATION OF APOPTOTIC ALKALINIZATION THROUGH PHOSPHORYLATION OF SODIUM HYDROGEN EXCHANGER VIA P38 MITOGEN ACTIVATED PROTEIN KI." Master's thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4316.

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Regulation of intracellular pH is responsible for many cellular processes, such as metabolism, cell cycle progression, and apoptosis. Many chemotherapeutic agents work by inducing target cells to undergo apoptosis, a cell death process still poorly understood. Previous studies demonstrated that a rise in intracellular pH activated apoptotic proteins leading to cytochrome C release. This "apoptotic alkalinization" occurred upon activation of the plasma membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In previous studies, upon cytok

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34

Perry, Leslie M. "Regulation of Alternative Sigma Factors During Oxidative and Ph Stresses in the Phototroph Rhodopseudomonas Palustris." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc700009/.

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Rhodopseudomonas palustris is a metabolically versatile phototrophic α-proteobacterium. The organism experiences a wide range of stresses in its environment and during metabolism. The oxidative an pH stresses of four ECF (extracytoplasmic function) σ-factors are investigated. Three of these, σ0550, σ1813, and σ1819 show responses to light-generated singlet oxygen and respiration-generated superoxide reactive oxygen species (ROS). The EcfG homolog, σ4225, shows a high response to superoxide and acid stress. Two proteins, one containing the EcfG regulatory sequence, and an alternative exported c

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35

Touati, Eliette. "La phosphatase acide de ph optimum 2,5 d'escherichia coli : un systeme pour l'etude des effets negatifs de l'amp cyclique." Paris 6, 1986. http://www.theses.fr/1986PA066531.

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36

Hong, Meng Yew. "Intracellular pH Regulation in H+-ATPase-rich Ionocytes in zebrafish larvae Using in vivo Ratiometric Imaging." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35749.

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The H+-ATPase rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium that are responsible for Na+ uptake and H+ extrusion. Current models of HR cell ion transport mechanisms in zebrafish larvae are well established, but little is known about the involvement of the various ion transport pathways in regulating intracellular acid-base status. In the present study, a ratiometric imaging technique using the pH indicator dye BCECF was developed to monitor intracellular pH (pHi) continuously in larval zebrafish HR cells in vivo. Initial valida

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37

Strecker, Kristina [Verfasser]. "Untersuchungen zur pH-Regulation am Blättermagenepithel des Schafes mit H+-sensitiven Mikroelektroden / Kristina Strecker, geb. Kosmis." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025239989/34.

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38

LE, PRIGENT KARINE. "Regulation du ph intracellulaire dans les myocytes cardiaques normaux et pathologiques : systemes membranaires dependants du sodium." Paris 11, 1997. http://www.theses.fr/1997PA112201.

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Les travaux de recherche, rapportes dans ce memoire de these, concernent la modulation des mecanismes membranaires de regulation du ph intracellulaire (ph#i), dependants du sodium, dans les myocytes cardiaques normaux et diabetiques. La premiere partie de ce travail a ete consacree a l'analyse de facteurs responsables de la diminution d'activite de l'echangeur na#+/h#+, observee au cours du diabete. Elle a permis de demontrer que, en l'absence de modification du pouvoir tampon intrinseque cellulaire pour les ions h#+, le diabete reduit significativement l'efflux acide via l'echangeur na#+/h#+

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39

Feldhaus, Heike Verfasser], Stefan [Akademischer Betreuer] Gründer, and Marc [Akademischer Betreuer] [Spehr. "ASIC-vermittelte Regulation des intrazellulären pH in Neuronen des murinen Kortex / Heike Feldhaus ; Stefan Gründer, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162451106/34.

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Feldhaus, Heike [Verfasser], Stefan Akademischer Betreuer] Gründer, and Marc [Akademischer Betreuer] [Spehr. "ASIC-vermittelte Regulation des intrazellulären pH in Neuronen des murinen Kortex / Heike Feldhaus ; Stefan Gründer, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162451106/34.

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41

May, Oliver [Verfasser]. "Regulation des elektrogenen Natrium Bikarbonat Kotransporters NBCe1 und der pH-Homöostase im Kolon der Maus / Oliver May." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1100314105/34.

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42

Heipertz, Katrin Sophie [Verfasser]. "Die vH⁺-ATPase und ihre Bedeutung für die pH-Regulation bei ovinen Pansenepithelzellen / Katrin Sophie Heipertz." Berlin : Freie Universität Berlin, 2007. http://d-nb.info/1022414917/34.

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43

Wilkins, Robert James. "The relation between cartilage acidity, the synthesis of its matrix and intracellular pH regulation in bovine articular chondrocytes." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334927.

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44

Zhu, Wen-hui, and 朱文輝. "Regulation of apotosis in human leukemic HL-60 cells: roles of caluium, protein kinase C and intacellular pH." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31235499.

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45

Ng, Fu Liang. "The impact of the blood pressure-associated genetic locus at SLC4A7 on gene expression and intracellular pH regulation." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24732.

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Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO3 - co-transporter NBCn1 which regulates intracellular pH (pHi) in a range of tissues, including vascular smooth muscle and endothelium. Notably, the SLC4A7 knockout mouse has been shown to have an altered blood pressure phenotype. This thesis presents a functional study of variants at this locus in primary cultures of vascular smooth muscle and endothelial cells. There were genotype-dependent differences in DNA-nuclear protein interact

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46

Parton, Richard M. "Confocal microscopy analysis of the roles of intracellular pH in the regulation of polarised growth of Dryopteris protonemata." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/15585.

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The roles of pH and [Ca<SUP>2+</SUP>] were investigated in relation to the maintenance and regulation of polarity in tip-growing <I>cells of Dryopteris affinis </I>protonemata. Intracellular [ion] was analysed by confocal microscopy of ion-sensitive dyes and ratio imaging. Initially, physiological and cytological aspects of tip growth in apical chlorocytes and rhizoid cells were examined. Findings are discussed in relation to the suitability of protonemata for the study of tip growth and with respect to other commonly studied cell types exhibiting polarised growth. Secondly, the suitability of

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47

Ladoux, Annie. "Etude du ph intracellulaire et de sa regulation au cours de la differentiation des cellules leucemiques myelomonocytaires humaines." Paris 7, 1988. http://www.theses.fr/1988PA077092.

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48

Zhu, Wen-hui. "Regulation of apotosis in human leukemic HL-60 cells : roles of caluium, protein kinase C and intacellular pH /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B16553226.

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49

Antoniel, Manuela. "The unique histidine of F-ATP synthase subunit OSCP mediates regulation of the permeability transition by matrix pH." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3427232.

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The “Permeability transition” (PT) is one of the most studied events that may trigger cell death and is due to a Ca2+- and ROS-dependent opening of a nonspecific pore, called PTP, whose molecular nature has been long debated. Recently, our research group has demonstrated that PTP forms from FoF1 ATP synthase dimers, demonstrating the ability of this complex to switch from the key enzyme for the aerobic synthesis of ATP into a potential cell death mediator. The goal of this PhD thesis has been to define which structural changes of ATP synthase are responsible for the pH modulation of PTP. Ind

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50

Veguilla, Rosa Angelica. "Transcriptional Regulation of OCA2 and POMC by a cAMP-Dependent Mechanism and Implications in Skin Pigmentation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10095.

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Skin Pigmentation represents the major natural protection against the deleterious effects of Ultraviolet light and involves a crosstalk between keratinocytes and melanocytes. Pigment synthesis or melanogenesis is initiated by the binding of \(\alpha\)-Melanocyte Stimulating Hormone \((\alpha-MSH)\) to the Melanocortin 1 Receptor (MC1R), expressed by the melanocytes. α-MSH is generated by cleavage of pro-opiomelanocortin hormone (POMC), produced by both melanocytes and keratinocytes. Activation of MC1R leads to an increase in cAMP levels, causing the expression of the transcription factor MITF

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