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Artykuły w czasopismach na temat „Pharyngeal gonorrhoea”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 19 lutego 2022

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1

Balachandran, T., A. P. Roberts, B. A. Evans, and B. S. Azadian. "Single-Dose Therapy of Anogenital and Pharyngeal Gonorrhoea with Ciprofloxacin." International Journal of STD & AIDS 3, no. 1 (January 1992): 49–51. http://dx.doi.org/10.1177/095646249200300112.

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A single dose of ciprofloxacin, 250 mg by mouth, was used in an open study to treat pharyngeal or rectal gonorrhoea or both in 64 patients (32 men and 32 women). The study also included 151 men with urethral gonorrhoea and 53 women with cervical or urethral gonorrhoea. Ciprofloxacin cured 63 (98%) patients with pharyngeal or rectal gonorrhoea (including 5 patients with penicillinase-producing Neisseria gonorrhoeae; PPNG), 147 (97%) men with urethral gonorrhoea (including 8 with PPNG) and 52 (98%) women with cervical or urethral gonorrhoea. All the isolates of N. gonorrhoeae were sensitive to 0

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2

McMillan, A., H. Young, and A. Moyes. "Rectal Gonorrhoea in Homosexual Men: Source of Infection." International Journal of STD & AIDS 11, no. 5 (May 2000): 284–87. http://dx.doi.org/10.1177/095646240001100502.

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The objective of this retrospective study was to determine the possible source of infection in homosexual men with rectal gonorrhoea: the probable source of rectal gonorrhoea was identified in 46/155 cases. Although the urethra was the site of infection in 33 (72%) of these contacts, only pharyngeal gonorrhoea was identified in 9 (20%) men. In 25/26 cases, there was concordance in the auxo/serotypes of Neisseria gonorrhoeae between contacts with urethral gonorrhoea and the index men with rectal gonorrhoea. Eleven out of 12 pharyngeal isolates were of the same auxo/serotype as the index cases.

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Marangoni, Antonella, Giacomo Marziali, Melissa Salvo, Antonietta D’Antuono, Valeria Gaspari, Claudio Foschi, and Maria Carla Re. "Mosaic structure of the penA gene in the oropharynx of men who have sex with men negative for gonorrhoea." International Journal of STD & AIDS 31, no. 3 (January 30, 2020): 230–35. http://dx.doi.org/10.1177/0956462419889265.

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The oropharynx represents a crucial site for the emergence of multi-drug resistance in Neisseria gonorrhoeae. The mosaic penA alleles, associated with decreased susceptibility to cephalosporins, have emerged by DNA recombination with partial penA genes, particularly those from commensal pharyngeal Neisseria species. Here, we investigated the prevalence of the mosaic structure of the penA gene in the oropharynx of men who have sex with men testing negative for pharyngeal gonorrhoea. From January 2016 to June 2018, 351 gonorrhoea-negative men who have sex with men attending a sexually transmitte

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Richardson, Daniel, Alice Pickering, Daniel Trotman, Kayleigh Nichols, Zoe Buss, John Devlin, and Fionnuala Finnerty. "Pharyngeal gonorrhoea in men who have sex with men." International Journal of STD & AIDS 32, no. 5 (February 3, 2021): 449–52. http://dx.doi.org/10.1177/0956462420975627.

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Pharyngeal gonorrhoea is important in the transmission dynamics of gonorrhoea, and generation of antimicrobial resistance and the performing of culture remains vital. We reviewed the notes of men who have sex with men (MSM) presenting to our clinic with a positive pharyngeal NAAT for gonorrhoea between January and December 2019. There were 383 cases of NAAT-positive pharyngeal gonorrhoea, and 28 (7%, 95% CI = 5.11–10.36) reported sore throat at presentation. Pharyngeal cultures were taken from 270/383 (70%), and 73/270 (27%) were culture positive with available antimicrobial sensitivities. Ove

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Kong, Fabian Y. S., Christina L. Hatzis, Andrew Lau, Deborah A. Williamson, Eric P. F. Chow, Christopher K. Fairley, and Jane S. Hocking. "Treatment efficacy for pharyngeal Neisseria gonorrhoeae: a systematic review and meta-analysis of randomized controlled trials." Journal of Antimicrobial Chemotherapy 75, no. 11 (August 3, 2020): 3109–19. http://dx.doi.org/10.1093/jac/dkaa300.

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Abstract Background Rising gonorrhoea rates require highly effective treatments to reduce transmission and prevent development of antimicrobial resistance. Currently the most effective treatments for pharyngeal gonorrhoea remain unclear. This review aimed to estimate treatment efficacy for pharyngeal gonorrhoea. Methods Online bibliographic databases were searched for the period 1 January 2000 to 17 September 2019 for treatments of gonorrhoea. All randomized controlled trials (RCTs) with data on pharyngeal gonorrhoea among participants aged 15 years or above, published in English, were include

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6

Janier, M., F. Lassau, I. Casin, and P. Morel. "Pharyngeal gonorrhoea: the forgotten reservoir." Sexually Transmitted Infections 79, no. 4 (August 1, 2003): 345. http://dx.doi.org/10.1136/sti.79.4.345.

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Lister, N. A., A. Smith, T. Read, and C. K. Fairley. "Testing men who have sex with men for Neisseria gonorrhoeae and Chlamydia trachomatis prior to the introduction of guidelines at an STD clinic in Melbourne." Sexual Health 1, no. 1 (2004): 47. http://dx.doi.org/10.1071/sh03005.

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Background: Guidelines for testing men who have sex with men (MSM) were published in 2002. They did not recommend asymptomatic screening for urethral gonorrhoea or pharyngeal screening for chlamydia. To determine if these guidelines were appropriate, we audited gonorrhoea and chlamydia testing of MSM at our centre. Methods: We carried out two audits at our Centre between August 2001 to July 2002. The first was an audit of testing MSM for gonorrhoea and/ or chlamydia over 12 days. The second was an audit of all positive tests over this 12-month period for gonorrhoea or chlamydia among MSM. Resu

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8

Barbee, Lindley A., and Matthew R. Golden. "Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis." Journal of Antimicrobial Chemotherapy 75, no. 7 (April 7, 2020): 1685–88. http://dx.doi.org/10.1093/jac/dkaa108.

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Abstract Background Ceftriaxone is the only consistently active antimicrobial agent recommended for the treatment of Neisseria gonorrhoeae. Although some new antimicrobials are in development, the necessity to expand treatment options in the near term may require using older drugs that have not been widely used to treat gonorrhoea. Methods We conducted a literature review of clinical trials and case series, published from 1983 to 2017, reporting treatment efficacy results following administration of 1 g aztreonam intramuscularly or IV for uncomplicated gonococcal infections. We summed trial da

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9

Comninos, Nicholas Byron, Linda Garton, Rebecca Guy, Denton Callander, Christopher K. Fairley, Andrew E. Grulich, Basil Donovan, Sian Louise Goddard, Alison Rutherford, and David J. Templeton. "Increases in pharyngeal Neisseria gonorrhoeae positivity in men who have sex with men, 2011–2015: observational study." Sexually Transmitted Infections 96, no. 6 (October 17, 2019): 432–35. http://dx.doi.org/10.1136/sextrans-2019-054107.

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ObjectivesPharyngeal gonorrhoea disproportionately affects men who have sex with men (MSM). We explored temporal trends in pharyngeal gonorrhoea positivity among MSM compared with anorectal and urogenital positivity.MethodsData (2011–2015) were extracted from 41 publicly funded sexual health clinics participating in a national surveillance network. Positivity was defined as the proportion of first-visit testing occasions where gonorrhoea was detected. Logistic regression explored trends in positivity and correlates of positive pharyngeal tests.ResultsFrom 2011 to 2015, 24 792 MSM tested (16 71

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10

Tapsall, John, Phillip Read, Christopher Carmody, Christopher Bourne, Sanghamitra Ray, Athena Limnios, Theo Sloots, and David Whiley. "Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods." Journal of Medical Microbiology 58, no. 5 (May 1, 2009): 683–87. http://dx.doi.org/10.1099/jmm.0.007641-0.

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Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l−1, which may have contributed to the treatment failures in these cases.

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11

Regan, David G., Ben B. Hui, James G. Wood, Helen Fifer, Monica M. Lahra, and David M. Whiley. "Treatment for pharyngeal gonorrhoea under threat." Lancet Infectious Diseases 18, no. 11 (November 2018): 1175–77. http://dx.doi.org/10.1016/s1473-3099(18)30610-8.

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Unemo, Magnus, Monica M. Lahra, Michelle Cole, Patricia Galarza, Francis Ndowa, Irene Martin, Jo-Anne R. Dillon, Pilar Ramon-Pardo, Gail Bolan, and Teodora Wi. "World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts." Sexual Health 16, no. 5 (2019): 412. http://dx.doi.org/10.1071/sh19023.

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Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a serious public health problem, compromising the management and control of gonorrhoea globally. Resistance in N. gonorrhoeae to ceftriaxone, the last option for first-line empirical monotherapy of gonorrhoea, has been reported from many countries globally, and sporadic failures to cure especially pharyngeal gonorrhoea with ceftriaxone monotherapy and dual antimicrobial therapies (ceftriaxone plus azithromycin or doxycycline) have been confirmed in several countries. In 2018, the first gonococcal isolates with ceftriaxone resistance pl

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13

Kinghorn, G. "Pharyngeal gonorrhoea: a silent cause for concern." Sexually Transmitted Infections 86, no. 6 (August 26, 2010): 413–14. http://dx.doi.org/10.1136/sti.2010.043349.

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Lusk, M. Josephine, Ruby N. N. Uddin, Monica M. Lahra, Frances L. Garden, Ratan L. Kundu, and Pam Konecny. "Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Prevalence in Urban Australian Heterosexuals?" Journal of Sexually Transmitted Diseases 2013 (June 26, 2013): 1–5. http://dx.doi.org/10.1155/2013/967471.

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We aim to characterize sexual behavioral aspects of heterosexual Neisseria gonorrhoea (NG) acquisition in two Sexually Transmitted Diseases clinics in Sydney, Australia, in 2008–2012. Of 167 NG cases, 102 were heterosexually acquired with a trend of increasing NG prevalence in heterosexuals from 1.1% (95% CI 0.6–2.1) in 2008 to 3.0% (95% CI 2.0–4.0) in 2012 (P=0.027). Of heterosexual male cases, unprotected fellatio was the likely sexual activity for NG acquisition in 21/69 (30.4%) and commercial sex work (CSW) contact the likely source in 28/69 (40.6%). NG prevalence overall in CSW (2.2%) was

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15

Chow, Eric P. F., Shayne Camilleri, Christopher Ward, Sarah Huffam, Marcus Y. Chen, Catriona S. Bradshaw, and Christopher K. Fairley. "Duration of gonorrhoea and chlamydia infection at the pharynx and rectum among men who have sex with men: a systematic review." Sexual Health 13, no. 3 (2016): 199. http://dx.doi.org/10.1071/sh15175.

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Background Chlamydia and gonorrhoea are the two most common sexually transmissible infections (STI) among men who have sex with men (MSM) worldwide. Infections at the pharynx and rectum are usually asymptomatic; however, the natural history of these infections remains unknown. The aim of this study is to estimate the duration of both infections at the extragenital sites from published epidemiological cohort studies. Methods: English peer-reviewed articles were searched from 1 January 2000 to 12 March 2015 in three electronic databases (MEDLINE, EMBASE and Cochrane Central). The prevalence-to-i

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Cornelisse, Vincent J., Christopher K. Fairley, Sandra Walker, Tameka Young, David Lee, Marcus Y. Chen, Catriona S. Bradshaw, and Eric P. F. Chow. "Adherence to, and acceptability of, Listerine® mouthwash as a potential preventive intervention for pharyngeal gonorrhoea among men who have sex with men in Australia: a longitudinal study." Sexual Health 13, no. 5 (2016): 494. http://dx.doi.org/10.1071/sh16026.

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We investigated whether men who have sex with men (MSM) would use mouthwash daily to prevent pharyngeal gonorrhoea. Ten MSM attending the Melbourne Sexual Health Centre were asked to use a Listerine® alcohol-containing mouthwash daily for 14 days in August 2015. Mouthwash was used at least once daily for 133 of 140 person-days (95% of days; 95% confidence interval 90–98%). All 10 men were willing to use mouthwash on a daily basis, and nine men were willing to use mouthwash after oral sex. This study showed that daily use of mouthwash is an acceptable intervention to prevent pharyngeal gonorrho

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Templeton, David J., Phillip Read, Rajesh Varma, and Christopher Bourne. "Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence." Sexual Health 11, no. 3 (2014): 217. http://dx.doi.org/10.1071/sh14003.

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Men who have sex with men (MSM) in Australia and overseas are disproportionately affected by sexually transmissible infections (STIs), including HIV. Many STIs are asymptomatic, so regular testing and management of asymptomatic MSM remains an important component of effective control. We reviewed articles from January 2009–May 2013 to inform the 2014 update of the 2010 Australian testing guidelines for asymptomatic MSM. Key changes include: a recommendation for pharyngeal chlamydia (Chlamydia trachomatis) testing, use of nucleic acid amplification tests alone for gonorrhoea (Neisseria gonorrhoe

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18

Sathia, Leena, Ben Ellis, Stuart Phillip, Alan Winston, and Alan Smith. "Pharyngeal gonorrhoea – is dual therapy the way forward?" International Journal of STD & AIDS 18, no. 9 (September 1, 2007): 647–48. http://dx.doi.org/10.1258/095646207781568556.

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Lister, Nichole A., Anthony Smith, and Christopher K. Fairley. "Introduction of screening guidelines for men who have sex with men at an STD clinic, the Melbourne Sexual Health Centre, Australia." Sexual Health 2, no. 4 (2005): 241. http://dx.doi.org/10.1071/sh05006.

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Background: A recent audit indicated that a substantial proportion of men who have sex with men (MSM) were not screened for rectal gonorrhoea and chlamydia at the Melbourne Sexual Health Clinic, Melbourne, Australia. In response, screening guidelines for MSM were introduced at the clinic using a computer reminder. The aim of this study was to evaluate the impact of the guidelines and alert on screening MSM for gonorrhoea and chlamydia. Methods: The medical records of MSM were reviewed for gonorrhoea and chlamydia screening by site (pharyngeal, urethral and rectal), four months before the imple

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20

Rajagopal, Preethi, Sian L. Goddard, and David J. Templeton. "Substantial increase in yield of Neisseria gonorrhoeae testing 2008–2013 at a Sydney metropolitan sexual health clinic: an observational study." Sexual Health 15, no. 1 (2018): 79. http://dx.doi.org/10.1071/sh17080.

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Background A substantial increase in gonorrhoea notifications in New South Wales has been observed in recent years. Methods: We assessed yield of testing and characteristics of those diagnosed with gonorrhoea from January 2008 to December 2013 at RPA Sexual Health in the inner-west of Sydney. Yield was defined as the proportion of testing occasions which were positive for gonorrhoea. Generalised estimating equations were used to calculate trends in yield over time. Results: During the 6-year study period, 6456 individuals (4308 males, 2124 females, 24 transgender individuals) were tested on 12

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Maddaford, Kate, Christopher K. Fairley, Sabrina Trumpour, Mark Chung, and Eric P. F. Chow. "Sites in the oropharynx reached by different methods of using mouthwash: clinical implication for oropharyngeal gonorrhoea prevention." Sexually Transmitted Infections 96, no. 5 (October 18, 2019): 358–60. http://dx.doi.org/10.1136/sextrans-2019-054158.

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ObjectivesOropharyngeal gonorrhoea is increasing among men who have sex with men and is commonly found in the tonsils and at the posterior pharyngeal wall. To address this rise, investigators are currently trialling mouthwash to prevent oropharyngeal gonorrhoea. We aimed to determine which parts of the oropharynx were reached by different methods of mouthwash use (oral rinse, oral gargle and oral spray).MethodsTwenty staff at Melbourne Sexual Health Centre participated in the study from March to May 2018. Participants were asked to use mouthwash mixed with food dye, by three application method

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Linhart, Y., T. Shohat, Z. Amitai, D. Gefen, I. Srugo, G. Blumstein, and M. Dan. "Sexually transmitted infections among brothel-based sex workers in Tel-Aviv area, Israel: high prevalence of pharyngeal gonorrhoea." International Journal of STD & AIDS 19, no. 10 (October 2008): 656–59. http://dx.doi.org/10.1258/ijsa.2008.008127.

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Sex workers play a major role in spreading sexually transmitted infections (STIs). We studied the prevalence rates and risk factors for STIs among 300 brothel-based sex workers in Tel-Aviv. Throat swabs were cultured for Neisseria gonorrhoeae, urine samples were tested by polymerase chain reaction (PCR) for Chlamydia trachomatis and N. gonorrhoeae, and sera were tested for syphilis, human immunodeficiency virus (HIV) and type 2 herpes simplex virus (HSV) antibodies. N. gonorrhoeae was cultured from throat samples of 9.0% of participants; PCR testing of urine was positive for C. trachomatis in

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Christophersen, J., A. C. Bollerup, E. From, J. O. Ronne-Rasmussen, and K. Quitzau. "Treating genitourinary and pharyngeal gonorrhoea with single dose ceftriaxone." Sexually Transmitted Infections 65, no. 1 (January 1, 1989): 14–17. http://dx.doi.org/10.1136/sti.65.1.14.

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Sulaiman, M. Z., C. M. Bates, J. B. Bittiner, C. A. Dixon, and R. C. Slack. "Response of pharyngeal gonorrhoea to single dose penicillin treatment." Sexually Transmitted Infections 63, no. 2 (April 1, 1987): 92–94. http://dx.doi.org/10.1136/sti.63.2.92.

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David, L. M. "Acquisition of pharyngeal gonorrhoea via sweets passed by mouth." Sexually Transmitted Infections 73, no. 2 (April 1, 1997): 146. http://dx.doi.org/10.1136/sti.73.2.146.

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Ross, J. D. C., A. McMillan, and H. young. "Changing trends of gonococcal infection in homosexual men in Edinburgh." Epidemiology and Infection 107, no. 3 (December 1991): 585–90. http://dx.doi.org/10.1017/s0950268800049281.

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SUMMARYIn an attempt to explain the recent resurgence of homosexually-acquired gonorrhoea in the Lothian region of Scotland the number of infections and pattern of infection (urethral, rectal and pharyngeal) of all gonococcal isolates from homosexual men attending the Department of Genitourinary Medicine at Edinburgh Royal Infirmary between 1985 and 1990 were analysed. Serovar typing data were available from infections acquired between January 1986 and December 1990. A correlation between one serovar, Bacejk/Brpyust, and the overall pattern of gonorrhoea was observed. The number of infections

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Wardropper, A. G., and R. S. Pattman. "Gonorrhoea as an Indicator of Altered Sexual Behaviour and as a Surrogate Marker of HIV Concern: A 13-Year Analysis in Newcastle." International Journal of STD & AIDS 6, no. 5 (September 1995): 348–50. http://dx.doi.org/10.1177/095646249500600508.

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Summary: It has been proposed that changes in sexual behaviour arising out of concerns regarding HIV infection can be inferred by changes in the incidence of gonorrhoea. We have reviewed data on gonococcal isolates in Newcastle over the last 13 years and looked at changes in relation to HIV test requests, new cases of HIV infection and media campaigns. HIV testing has been available in the clinic since late 1985. There was a steady decline in cases of gonorrhoea from 1985–1991 and then as in other areas an increase in incidence was seen among homosexual and bisexual men. The majority of this r

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Mitchell, M., V. Rane, C. K. Fairley, D. M. Whiley, C. S. Bradshaw, M. Bissessor, and M. Y. Chen. "Sampling technique is important for optimal isolation of pharyngeal gonorrhoea." Sexually Transmitted Infections 89, no. 7 (May 21, 2013): 557–60. http://dx.doi.org/10.1136/sextrans-2013-051077.

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Wardropper, A., and R. S. Pattman. "Single Dose Therapy of Anogenital and Pharyngeal Gonorrhoea with Ciprofloxacin." International Journal of STD & AIDS 3, no. 5 (September 1992): 372. http://dx.doi.org/10.1177/095646249200300518.

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Hananta, IPY, MF Schim van der Loeff, AP van Dam, H. Soebono, and HJC de Vries. "P05.06 Prolonged infection of pharyngeal gonorrhoea after treatment with ceftriaxone." Sexually Transmitted Infections 91, Suppl 2 (September 2015): A110.1—A110. http://dx.doi.org/10.1136/sextrans-2015-052270.292.

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Ross, Jonathan DC, Jan Harding, Lelia Duley, Alan A. Montgomery, Trish Hepburn, Wei Tan, Clare Brittain, et al. "Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT." Health Technology Assessment 23, no. 20 (May 2019): 1–104. http://dx.doi.org/10.3310/hta23200.

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Background Gonorrhoea is a common sexually transmitted infection that can cause pain and discomfort, affect fertility in women and lead to epididymo-orchitis in men. Current treatment is with ceftriaxone, but there is increasing evidence of antimicrobial resistance reducing its effectiveness. Gentamicin is a potential alternative treatment requiring further evaluation. Objectives To assess the clinical effectiveness and cost-effectiveness of gentamicin as an alternative treatment to ceftriaxone in the treatment of gonorrhoea. Design A multicentre, parallel-group, blinded, non-inferiority rando

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Unemo, Magnus, Josefine Ahlstrand, Leonor Sánchez-Busó, Michaela Day, David Aanensen, Daniel Golparian, Susanne Jacobsson, et al. "High susceptibility to zoliflodacin and conserved target (GyrB) for zoliflodacin among 1209 consecutive clinical Neisseria gonorrhoeae isolates from 25 European countries, 2018." Journal of Antimicrobial Chemotherapy 76, no. 5 (February 10, 2021): 1221–28. http://dx.doi.org/10.1093/jac/dkab024.

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Abstract Objectives Novel antimicrobials for treatment of gonorrhoea are imperative. The first-in-class spiropyrimidinetrione zoliflodacin is promising and currently in an international Phase 3 randomized controlled clinical trial (RCT) for treatment of uncomplicated gonorrhoea. We evaluated the in vitro activity of and the genetic conservation of the target (GyrB) and other potential zoliflodacin resistance determinants among 1209 consecutive clinical Neisseria gonorrhoeae isolates obtained from 25 EU/European Economic Area (EEA) countries in 2018 and compared the activity of zoliflodacin wit

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Jasper, William, Madeleine Macdonald, Danayan Luxmanan, Elizabeth Foley, and Rajul Patel. "Telephone-triage services do not lead to an increased wait time for assessment of gonorrhoea in symptomatic patients." International Journal of STD & AIDS 32, no. 9 (May 5, 2021): 852–55. http://dx.doi.org/10.1177/0956462421999280.

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In Spring 2017, Southampton and Portsmouth Sexual Health Services (SHSs) replaced an overstretched walk-in service with a telephone-triage service: patients calling that were symptomatic, vulnerable or at high risk of having an STI were invited into a clinic, whereas others were signposted to remote self-sample NHS postal testing services. This study aimed to establish whether patient care was disadvantaged by the introduction of the triage service. Electronic patient notes for all patients attending for treatment of gonorrhoea for two years before and for two years after the service change we

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Bennett, Amy, Katie Jeffery, Eunan O’Neill, and Jackie Sherrard. "Outbreak or illusion: consequences of ‘improved’ diagnostics for gonorrhoea." International Journal of STD & AIDS 28, no. 7 (July 12, 2016): 667–71. http://dx.doi.org/10.1177/0956462416660928.

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The sexual health service in Oxford introduced gonorrhoea nucleic amplification acid testing using the BD Viper XTR™ System. For practical reasons, a confirmatory nucleic amplification acid testing using a different platform was not used initially. Following the introduction of nucleic amplification acid testing, the rates of gonorrhoea increased threefold. Concerns were raised that this increase represented an outbreak. A retrospective review of cases over six months suggested that there may have been a number of false-positive results. A prospective study was then undertaken over six months,

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Koedijk, F. D. H., J. E. A. M. van Bergen, N. H. T. M. Dukers-Muijrers, A. P. van Leeuwen, C. J. P. A. Hoebe, and M. A. B. van der Sande. "The value of testing multiple anatomic sites for gonorrhoea and chlamydia in sexually transmitted infection centres in the Netherlands, 2006–2010." International Journal of STD & AIDS 23, no. 9 (September 2012): 626–31. http://dx.doi.org/10.1258/ijsa.2012.011378.

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National surveillance data from 2006 to 2010 of the Dutch sexually transmitted infection (STI) centres were used to analyse current practices on testing extragenital sites for chlamydia and gonorrhoea in men who have sex with men (MSM) and women. In MSM, 76.0% and 88.9% were tested at least at one extragenital site (pharyngeal and/or anorectal) for chlamydia and gonorrhoea, respectively; for women this was 20.5% and 30.2%. Testing more than one anatomic site differed by STI centre, ranging from 2% to 100%. In MSM tested at multiple sites, 63.0% and 66.5% of chlamydia and gonorrhoea diagnoses,

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Read, P. J., H. Wand, R. Guy, A. McNulty, and B. Donovan. "P1-S2.19 Unprotected fellatio and pharyngeal gonorrhoea in Sydney sex workers." Sexually Transmitted Infections 87, Suppl 1 (July 1, 2011): A130—A131. http://dx.doi.org/10.1136/sextrans-2011-050108.76.

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Y. Chen, M., K. Stevens, R. Tideman, A. Zaia, T. Tomita, C. K. Fairley, M. Lahra, D. Whiley, and G. Hogg. "Failure of 500 mg of ceftriaxone to eradicate pharyngeal gonorrhoea, Australia." Journal of Antimicrobial Chemotherapy 68, no. 6 (February 6, 2013): 1445–47. http://dx.doi.org/10.1093/jac/dkt017.

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Wardropper, A., and R. S. Pattman. "An increase in pharyngeal gonorrhoea: cause for concern regarding HIV infection." Sexually Transmitted Infections 68, no. 5 (October 1, 1992): 343–44. http://dx.doi.org/10.1136/sti.68.5.343.

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Mitchell, M., V. Rane, C. K. Fairley, D. M. Whiley, C. S. Bradshaw, M. Bissessor, and M. Y. Chen. "P2.034 Sampling Technique is Important For Optimal Isolation of Pharyngeal Gonorrhoea." Sexually Transmitted Infections 89, Suppl 1 (July 2013): A98.1—A98. http://dx.doi.org/10.1136/sextrans-2013-051184.0299.

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Fairley, Christopher K., Marcus Y. Chen, Catriona S. Bradshaw, and Sepehr N. Tabrizi. "Is it time to move to nucleic acid amplification tests screening for pharyngeal and rectal gonorrhoea in men who have sex with men to improve gonorrhoea control?" Sexual Health 8, no. 1 (2011): 9. http://dx.doi.org/10.1071/sh10134.

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The use of nucleic acid amplification tests (NAAT), as well as or in preference to culture for non-genital sites is now recommended both in Australia and overseas because of their greater sensitivity and improved specificity. A survey of 22 Australian sexual health clinics who each year test over 14 500 men who have sex with men (MSM) show that culture remains the predominate method for detecting gonorrhoea at pharyngeal (64%) and rectal (73%) sites. This editorial discusses the potential disadvantages of using culture over NAAT in relation to optimal gonorrhoea control among MSM and advocates

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&NA;. "Single-dose oral azithromycin 2g is highly effective in treating pharyngeal gonorrhoea,." Inpharma Weekly &NA;, no. 1553 (September 2006): 15. http://dx.doi.org/10.2165/00128413-200615530-00037.

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McMillan, A., and H. Young. "The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime." International Journal of STD & AIDS 18, no. 4 (April 2007): 253–54. http://dx.doi.org/10.1258/095646207780658971.

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Latimer, Rosie Louise, Lenka Vodstrcil, Vesna De Petra, Christopher K. Fairley, Tim RH Read, Deborah Williamson, Michelle Doyle, Eric PF Chow, and Catriona Bradshaw. "Extragenital Mycoplasma genitalium infections among men who have sex with men." Sexually Transmitted Infections 96, no. 1 (June 19, 2019): 10–18. http://dx.doi.org/10.1136/sextrans-2019-054058.

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ObjectivesThere are limited data on the prevalence of Mycoplasma genitalium (Mgen) coinfection with rectal chlamydia (Chlamydia trachomatis (CT)) and rectal gonorrhoea (Neisseria gonorrhoeae (NG)) infections and few studies examining the prevalence of pharyngeal Mgen in men who have sex with men (MSM). Using transcription-mediated amplification assay, this study aimed to determine the proportion of rectal CT and rectal NG infections in MSM who are coinfected with rectal Mgen, and the proportion of MSM with Mgen detected in the pharynx in order to inform clinical practice.MethodsThis was a cros

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Bakhtiar, M., and P. L. Samarasinghe. "Enoxacin as one day oral treatment of men with anal or pharyngeal gonorrhoea." Sexually Transmitted Infections 64, no. 6 (December 1, 1988): 364–66. http://dx.doi.org/10.1136/sti.64.6.364.

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COKER, D. M., I. AHMED-JUSHUF, O. P. ARYA, J. S. CHESSBROUGH, and B. C. PRATT. "Evaluation of single dose dprofloxadn in the treatment of rectal and pharyngeal gonorrhoea." Journal of Antimicrobial Chemotherapy 24, no. 2 (1989): 271–72. http://dx.doi.org/10.1093/jac/24.2.271.

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Hiransuthikul, Akarin, Rena Janamnuaysook, Thanthip Sungsing, Jureeporn Jantarapakde, Deondara Trachunthong, Steve Mills, Ravipa Vannakit, Praphan Phanuphak, and Nittaya Phanuphak. "High burden of chlamydia and gonorrhoea in pharyngeal, rectal and urethral sites among Thai transgender women: implications for anatomical site selection for the screening of STI." Sexually Transmitted Infections 95, no. 7 (April 13, 2019): 534–39. http://dx.doi.org/10.1136/sextrans-2018-053835.

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ObjectiveComprehensive data on Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections to guide screening services among transgender women (TGW) are limited. We studied the burden of CT/NG infections in pharyngeal, rectal and urethral sites of Thai TGW and determined missed CT/NG diagnoses if selected site screening was performed.MethodsThai TGW were enrolled to the community-led test and treat cohort. CT/NG screening was performed from pharyngeal swab, rectal swab and urine using nucleic acid amplification test. CT/NG prevalence in each anatomical site was analysed, along with th

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Walker, sandra, Clare Bellhouse, Jade Bilardi, Christopher Fairley, and Eric Chow. "P145 Australian MSM’s views and knowledge of pharyngeal gonorrhoea, willingness to change current sexual practices and the acceptability of using mouthwash to reduce the risk of pharyngeal gonorrhoea: A qualitative study." Sexually Transmitted Infections 92, Suppl 1 (June 2016): A70.1—A70. http://dx.doi.org/10.1136/sextrans-2016-052718.199.

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Chow, Eric P. F., Sandra Walker, Tim R. H. Read, Marcus Y. Chen, Catriona S. Bradshaw, and Christopher K. Fairley. "Self-Reported Use of Mouthwash and Pharyngeal Gonorrhoea Detection by Nucleic Acid Amplification Test." Sexually Transmitted Diseases 44, no. 10 (October 2017): 593–95. http://dx.doi.org/10.1097/olq.0000000000000654.

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Beymer, Matthew R., Michelle A. DeVost, Robert E. Weiss, Rhodri Dierst-Davies, Chelsea L. Shover, Raphael J. Landovitz, Corinne Beniasians, et al. "Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California." Sexually Transmitted Infections 94, no. 6 (February 27, 2018): 457–62. http://dx.doi.org/10.1136/sextrans-2017-053377.

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BackgroundPre-exposure prophylaxis (PrEP) is an effective method for reducing HIV incidence among at-risk populations. However, concerns exist over the potential for an increase in STIs following PrEP initiation. The objective of this study is to compare the STI incidence before and after PrEP initiation within subjects among a cohort of men who have sex with men in Los Angeles, California.MethodsThe present study used data from patients who initiated PrEP services at the Los Angeles LGBT Center between October 2015 and October 2016 (n=275). A generalised linear mixed model was used with a cas

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Artykov, R., R. K. Rabiu, and J. A. White. "O4 Pharyngeal gonorrhoea: assessing treatment responses in an era of uncertainty: Abstract O4 Table 1." Sexually Transmitted Infections 88, Suppl 1 (May 23, 2012): A2.1—A2. http://dx.doi.org/10.1136/sextrans-2012-050601a.4.

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