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Rozprawy doktorskie na temat „Phosphoribosyltransferase”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 4 lutego 2022

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1

Catton, Gemma R. "Mechanistic studies on quinolinate phosphoribosyltransferase /." St Andrews, 2007. http://hdl.handle.net/10023/485.

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Catton, Gemma Rachel. "Mechanistic studies on quinolinate phosphoribosyltransferase." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/485.

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Quinolinate phosphoribosyltransferase (QPRTase, EC 2.4.2.19) is an intriguing enzyme which appears to catalyse two distinct chemical reactions; transfer of a phosphoribosyl moiety from 5-phosphoribosyl-1-pyrophosphate to the nitrogen of quinolinic acid and decarboxylation at the 2-position to give nicotinic acid mononucleotide. The chemical mechanism of QPRTase is not fully understood. In particular, enzymatic involvement in the decarboxylation step is yet to be conclusively proven. QPRTase is neurologically important as it degrades the potent neurotoxin, quinolinic acid, implicated in disease

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3

Marinaki, Anthony Marin. "The biochemical and molecular basis of Hypoxanthine-guanine phosphoribosyltransferase deficiency." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26969.

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Hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyses the first step in purine salvage. A complete deficiency of the enzyme results in the devastating neurological symptoms of the Lesch-Nyhan syndrome. The Lesch-Nyhan syndrome is characterised by purine overproduction leading to, hyperuricemia and gout and a central nervous system disorder characterised by severe, spasticity, choreoathetosis, mental retardation and compulsive self-mutilatory behaviour, A partial deficiency of the enzyme results in purine overproduction, gout and occasionally, mild neurological symptoms. Patients are

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4

Murungi, Edwin Kimathi. "Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9199_1257245819.

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<p>Malaria remains the most important parasitic disease worldwide. It is estimated that over 500 million infections and more that 2.7 million deaths arising from malaria occur each year. Most (90%) of the infections occur in Africa with the most affected groups being children of less than five years of age and women. this dire situation is exacerbated by the emrggence of drug resistant strains of Plasmodium falciparum. The work reported in this thesis focuses on improving the purification of PfHPRT by investigating the characteristics of anion exchange DE-52 chromatography (the first stage of

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5

Ford, Barry Noel. "Structure-function relationships in Chinese hamster adenine phosphoribosyltransferase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34263.pdf.

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6

Shahabuddin, Mohammed. "Molecular studies on the hypoxanthine phosphoribosyltransferase of Plasmodium falciparum." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14382.

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Hypoxanthine phosphoribosyltransferase (EC 2.7.2.8) of P.falciparum has been studied for its biological properties and cellular location. The enzyme plays an important role in the parasite's life, and therefore is a putative target for chemotherapy against malaria. Due to the difficulty in obtaining large amounts of the enzyme from the parasite, it was over-expressed in E.coli, first as a fusion protein with E.co/i-j8-galactosidase. This facilitated the one step purification of the protein, using /3-galactosidase substrate affinity chromatography, for making antibodies against the enzyme. The

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7

Mittelstädt, Gerd Horst. "Allosteric regulation of the adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni." Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/10799.

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The enzyme adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyses the first reaction of the histidine biosynthetic pathway. ATP-PRT also represents a metabolic control point, directing the flux of metabolites through this energetically expensive pathway. Two distinctly different forms of ATP-PRT exist, the long form and the short form, which differ in the presence of a C-terminal regulatory domain. In the short form, where this domain is absent, it is functionally replaced by a regulatory protein, called HisZ. ATP-PRT activity is modulated by two layers of regulation: active site

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8

Evans, Laura. "Investigating the role of nicotinamide phosphoribosyltransferase (NAMPT) in cartilage catabolism." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58335/.

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NAMPT (nicotinamide phosphoribosyltransferase) is a universally expressed protein elevated in the serum and synovial fluid of rheumatoid arthritis (RA) sufferers. NAMPT is a rate-limiting enzyme in the biosynthesis of (nicotinamide adenine dinucleotide) NAD+, an essential cellular coenzyme, and has also been shown to exert cytokine-like activities as a mediator of innate immunity. However little is currently known of the role of NAMPT in cartilage metabolism. In this thesis, the role and regulation of NAMPT was studied in a variety of model systems. Addition of exogenous (e)NAMPT to fibroblast

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9

Duckworth, Megan Jane Medical Sciences Faculty of Medicine UNSW. "Characterisation of the xanthineguanine phosphoribosyltransferase of helicobacter pylori as a potential therapeutic target." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43418.

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Helicobacter pylori infects more than half of the global population and causes gastric disorders. The increasing development of antibiotic resistance by the bacterium continues to limit treatment options. The identification and characterisation of novel therapeutic targets are necessary for successful future treatment of the infection. One potential target for therapeutic intervention is the gpt gene encoded by hp0735 (jhp0672) in H. pylori strain 26695 (J99). This gene produces a putative xanthine-guanine phosphoribosyltransferase (XGPRTase), an enzyme of the purine salvage synthesis pathway

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10

Phehane, Vuyisile Ntosi. "The expression and drug targeting of parasitic hypoxanthine-guanine phosphoribosyltransferase (HGPRT)." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/2701.

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Bibliography: leaves 231-243.<br>We have expressed and purified human, two forms of P. falciparum, and Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HPRT) in E. coli using the pET expression system. The cDNA encoding the ORF of HPRT was amplified by PCR and transformed into E. coli cells using standard methods. Expression was induced by IPTG and reached about 13% of the total cell protein for all four proteins. The HPRTs were purified by nickel affinity chromatography most of the expressed protein could be isolated from the crude supernatant fraction in a soluble form. Huma

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11

Sintra, Pisco João. "Studies on the mechanism of allosteric regulation of M. tuberculosis ATP-phosphoribosyltransferase." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046004/.

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Allosteric regulation is an efficient way of controlling enzymatic activity. In Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, ATPphosphoribosyltransferase (ATP-PRT) catalyses the first and committed step of the biosynthesis of L-histidine (L-His). L-His biosynthetic pathway is essential for Mtb and is absent in humans, making ATP-PRT an attractive target for the development of novel antibiotics. ATP-PRT is a hexamer in solution and, like other enzymes regulated via ferrodoxin-like (FL) domains, interconverts between an open active and a closed inactive conformati

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12

Colgin, Lorel Melanie. "Spontaneous mutations in aging human renal epithelia in vivo /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6318.

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13

Junior, Alécio Antonio Pimenta. "Estudos estruturais e correlação com a síndrome urolitíase de mutantes da adenina fosforribosiltransferase humana." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-29082011-095840/.

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A 2,8-DHA Urolitíase é uma doença resultante de uma desordem hereditária que leva a deficiência de atividade da enzima APRT do grupo das PRTases. Até o momento, foram encontradas 18 mutações em pacientes, das quais 7 são missense. O presente trabalho dedica-se ao estudo funcional e estrutural dessas 7 mutações e da deleção ΔF173. Construções dos mutantes D65V, L110P, M136T, R67Q, R89Q, I112F e F173G foram obtidas no vetor pET-29a(+) e clonados em E. coli. Os protocolos de expressão e purificação foram estabelecidos, onde as enzimas foram obtidas após uma etapa cromatográfica na coluna CH

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14

Nelson, Aileen A. "The significance of adenine phosphoribosyltransferase for DNA excision repair processes in friend erythroleukaemia cells." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241676.

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15

Mbewe, Boniface. "Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT)." Doctoral thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/2696.

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Includes bibliographical references.<br>The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification. On an analytical scale (40 ml culture), a purification procedure was developed that involves extraction of contaminating proteins by anion exchange chromatography (HGXPRT does not bind under the conditions used), followed by Reactive Red 120 agarose affinity chromatography.

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16

GIMBERT, LUC. "A propos d'un nouveau cas de lithiase de 2,8 dihydroxyadenine par deficit complet en adenine phosphoribosyltransferase et de son traitement par une dissolution in situ." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20401.

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17

Lorenz, Veronika. "Komplexe Veränderungen in der Genexpression der Ecto-Nukleosid-5-Triphosphat-Diphosphohydrolase bei Hypoxanthin-Phosphoribosyltransferase-Defizienz." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1207/.

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18

Cookson, Tammie Violet Marie. "Probing the active site of anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis to facilitate novel drug development." Thesis, University of Canterbury. Chemistry, 2013. http://hdl.handle.net/10092/9049.

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Caused by the organism Mycobacterium tuberculosis (Mtu), the globally distributed disease tuberculosis was responsible for the deaths of 1.4 million people in 2011. Anthranilate phosphoribosyltransferase (AnPRT) is an enzyme that catalyses the second committed step of the tryptophan biosynthetic pathway within Mtu, and is a promising target for antibiotics. This research aimed to further understand the mechanics of the AnPRT active site, in order to provide useful information towards AnPRT drug design. AnPRT inhibition and alternate substrates were investigated as well as variant AnPRT protei

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19

Elangovan, Venkateswaran Ramamoorthi, Sara M. Camp, Gabriel T. Kelly, Ankit A. Desai, Djanybek Adyshev, Xiaoguang Sun, Stephen M. Black, Ting Wang, and Joe G. N. Garcia. "Endotoxin- and Mechanical Stress–Induced Epigenetic Changes in the Regulation of the Nicotinamide Phosphoribosyltransferase Promoter." UNIV CHICAGO PRESS, 2016. http://hdl.handle.net/10150/622492.

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Mechanical ventilation, a lifesaving intervention for patients with acute respiratory distress syndrome (ARDS), also unfortunately contributes to excessive mechanical stress and impaired lung physiological and structural integrity. We have elsewhere established the pivotal role of increased nicotinamide phosphoribosyltransferase (NAMPT) transcription and secretion as well as its direct binding to the toll-like receptor 4 (TLR4) in the progression of this devastating syndrome; however, regulation of this critical gene in ventilator-induced lung injury (VILI) is not well characterized. On the ba

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20

Gaillard, Catherine. "Contribution a l'etude du role des genes d'adenine phosphoribosyltransferase dans le metabolisme des cytokinines chez les plantes." Paris 11, 1997. http://www.theses.fr/1997PA112034.

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Les cytokinines sont impliquees dans de nombreux aspects de la croissance et du developpement des plantes. Nous avons entrepris de cloner les genes impliques dans l'interconversion entre les formes base, riboside et ribotide des cytokinines dans le but d'elucider leur role dans le transport des cytokinines et la regulation de leurs teneurs dans les plantes. Cette interconversion peut etre assuree par des enzymes de la voie de recuperation des purines. L'apt (adenine phosphoribosyltransferase), qui convertit l'adenine en amp, agit egalement sur les cytokinines. La conversion de la benzyladenine

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21

LoCoco, Peter M. "Pharmacological Stimulation of Nicotinamide Phosphoribosyltransferase with P7c3-A20 as a Protective Strategy for Paclitaxel-Induced Peripheral Neuropathy." Thesis, The University of Texas Health Science Center at San Antonio, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10273903.

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<p> Improvements in anticancer pharmacotherapy over the past 40 years have led to a steady increase in the number of cancer survivors worldwide. The clinical effectiveness of anticancer agents like the microtubule-stabilizing agent, paclitaxel, ultimately led to their adoption into standard of care regimens for most cancers. What makes these drugs so effective is how they bind to their respective targets to disrupt fundamental cellular processes. For example, by binding to β-tubulin, paclitaxel induces polymerization and stabilization of cellular microtubules, leading to impairments in ce

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22

Hyland, Paula Lisa. "Sequence analysis of the adenine phosphoribosyltransferase gene locus in wild-type and thymidine kinase-deficient friend erythroleukaemia cells." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390158.

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23

Caldas, Victor Emanoel Armini. "Adenina fosforibosiltransferase de Schistosoma mansoni: proposta de detalhamento do mecanismo catalítico por dinâmica molecular." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-19102011-141742/.

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A Adenina Fosforibosiltransferase (APRT E.C. 2.4.2.7) pertence à família de enzimas Fosforibosil Transferases (PRTase) do Tipo I , que catalisa a conversão reversível de Adenina e 5-fosfo-α-D-ribose-1-difosfato (PRPP) em difosfato e adenosina monofosfato, um importante precursor energético da célula. A APRT integra a via de salvação de purinas, única forma de suprir o balanço de purinas em Schistosoma mansoni. Este trabalho apresenta o isolamento, clonagem, expressão heteróloga e purificação da APRT de S. mansoni a fim de caracterizá-la quanto seus parâmetros físico-químicos. Não se obt

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Livingstone, Emma Kathrine. "Allosteric Regulation of the First Enzyme in Histidine Biosynthesis." Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/10470.

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The ATP-PRTase enzyme catalyses the first committed step of histidine biosynthesis in archaea, bacteria, fungi and plants.1 As the catalyst of an energetically expensive pathway, ATP-PRTase is subject to a sophisticated, multilevel regulatory system.2 There are two families of this enzyme, the long form (HisGL) and the short form (HisGS) that differ in their molecular architecture. A single HisGL chain comprises three domains. Domains I and II house the active site of HisGL while domain III, a regulatory domain, forms the binding site for histidine as an allosteric inhibitor. The long form ATP

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25

Dantas, Deyse de Souza. "Caracterização estrutural e bioquimica da hipoxantina-guanina-xantina fosforribosiltransferase." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314756.

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Orientadores: Gonçalo Amarante Guimarães Pereira, Francisco Javier Medrano Martin<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T15:38:56Z (GMT). No. of bitstreams: 1 Dantas_DeysedeSouza_D.pdf: 4937353 bytes, checksum: 5c9b26f6ef8ed34e974ca6c8bb0708f2 (MD5) Previous issue date: 2008<br>Resumo: Os genes que codificam para a 6-oxopurina fosforribosiltransferase (HPRT, EC2.4.2.8) dos organismos Pyrococcus horikoshii e Schistosoma mansoni foram clonados em vetores de expressão. As proteínas foram expressas e purificadas em

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26

Lecomte, Isabelle. "Métabolisme purique chez le pécher. Recherche d'enzymes marqueurs de potentialités de croissance des bourgeons : étude de l'adénine phosphoribosyltransferase et de l'adénosine nucleosidase." Clermont-Ferrand 2, 1999. http://www.theses.fr/1999CLF22165.

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Chez les plantes pérennes, il existe une relation entre la régulation du contenu en nucléosides triphosphates après un traitement exogène à l'adénosine et l'aptitude à la croissance des bourgeons (test nucléotides). Chez le pécher, l'adénosine exogène est préférentiellement recyclée en nucléotides adenyliques par une voie indirecte faisant intervenir une adénosine nucleosidase et une adénine phosphoribosyltransferase. Pendant plusieurs périodes automno-hivernales successives, l'examen de l'activité de ces enzymes a été réalisé au niveau des bourgeons végétatifs et floraux de cette espèce végét

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27

Grant, Donna. "Mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene in T lymphocytes from arthritis patients and in human B lymphoid cell lines exposed to nitric oxide-donating drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0001/MQ46576.pdf.

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Kallies, Mathias Sebastian [Verfasser], and George [Akademischer Betreuer] Iliakis. "The effect of high linear energy transfer ionizing radiation on mutation and reversion events at the hypoxanthin-guanin-phosphoribosyltransferase locus / Mathias Sebastian Kallies ; Betreuer: George Iliakis." Duisburg, 2017. http://d-nb.info/1133478794/34.

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Petitgas, Céline. "Etude des mécanismes pathogéniques de la maladie de Lesch-Nyhan en relation avec le système dopaminergique chez un organisme modèle, Drosophila melanogaster." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLET049.

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L’adénine phosphoribosyltransférase (APRT) et l’hypoxanthine-guanine phosphoribosyltransférase (HGPRT) sont deux enzymes majeures impliquées dans le recyclage des purines chez les Mammifères, une voie métabolique essentielle permettant la récupération des bases puriques dérivées de l’alimentation ou de la dégradation des nucléotides. La voie de sauvetage des purines est en effet moins coûteuse en énergie que la voie de synthèse de novo et son dysfonctionnement induit diverses pathologies. En particulier, des mutations héréditaires supprimant l’activité de l’HGPRT sont associées à la maladie de

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30

Monzani, Paulo Sérgio. "Estrutura cristalográfica da enzima hipoxantina-guanina fosforibosiltransferase (HGPRT) de Leishmania tarentolae complexada com GMP." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-24062008-163341/.

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O presente trabalho teve como objetivos a clonagem, expressão e purificação da proteína HGPRT de Leishimania tarentolae, para a caracterização e cristalização dessa enzima, a fim do seu estudo estrutural e funcional. O gene da HGPRT foi amplificado a partir de uma biblioteca genômica de Leishmania tarentolae da cepa UC Lambda ZAP Express BamHI-Sal3A I. Esse gene foi clonado no vetor de expressão pET29a(+) e usado na transformação da bactéria Escherichia coli BL21 (DE3). Esse sistema de expressão apresentou uma superexpressão da proteína recombinante, que foi purificada em cromatografia de form

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Townsend, Michelle Hannah. "The Clinical Significance of HPRT as a Diagnostic and Therapeutic Biomarker for Hematological and Solid Malignancies." Thesis, Brigham Young University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10846744.

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<p> An estimated 1,735,350 new cancer diagnosis and 609,640 cancer related deaths are predicted to occur in the United States in 2018. To improve patient prognosis, biomarkers are needed to identify cancer in early stages. When diagnosed at an early stage, cancer is more likely to respond to treatments and patients have a higher survival rate. Consequently, there is an ever-present need to identify biomarkers that can aid in the detection of cancer. Additionally, there is a paradigm shift in the field of cancer treatment towards immunotherapy. Traditional cancer treatments include chemotherapy

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Montigny, Jacky de. "Ura5 et ura10, deux genes codant pour deux isoenzymes a activite omp pyrophosphorylase chez la levure saccharomyces cerevisiae : structure, expression et regulation." Strasbourg 1, 1988. http://www.theses.fr/1988STR13198.

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Mitchell, Shaneice Renee. "Preclinical evaluation of NAMPT inhibitor KPT-9274 in Acute Myeloid Leukemia." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1546527486477125.

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Fattori, Ana Carolina Maragno. "Efeitos da imunização com Adenosina Quinase (AK) e Hipoxantina-Guanina Fosforibosiltransferase (HGPRT) recombinantes de Schistosoma mansoni : controle da infecção murina." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7924.

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Submitted by Luciana Sebin (lusebin@ufscar.br) on 2016-10-11T12:04:16Z No. of bitstreams: 1 DissACMF.pdf: 2760486 bytes, checksum: 27824647d350872bddb22f28a9206da8 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-20T13:38:00Z (GMT) No. of bitstreams: 1 DissACMF.pdf: 2760486 bytes, checksum: 27824647d350872bddb22f28a9206da8 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-20T13:38:07Z (GMT) No. of bitstreams: 1 DissACMF.pdf: 2760486 bytes, checksum: 27824647d350872bddb22f28a9206da8 (MD5)<br>Made available in

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Romanello, Larissa. "Estudos das enzimas adenosina kinase isoforma 1, hipoxantina-guanina fosforibosiltransferase isoformas 1, 2 e 3, adenilsuccinato liase, adenilsuccinato sintetase de Schistosoma mansoni." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-27102016-102455/.

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O Schistosoma mansoni, parasita responsável pela esquistossomose (barriga dágua), doença que afeta cerca de 300 milhões de pessoas em todo mundo, não possui a via de síntese de purinas, dependendo integralmente da via de salvação de purinas para seu suprimento dessas bases. Uma vez que a terapia se resume a administração de um único fármaco, o praziquantel, diversos casos de resistência do parasita a esse medicamento foram reportadas, sendo assim esta via tem sido citada como alvo potencial para o desenvolvimento de novos fármacos contra a doença. As enzimas adenosina kinase (AK), hipoxantina-

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Pétriacq, Pierre. "Etude de la biosynthese du nad chez les plantes : conséquences physiologiques de sa manipulation chez Arabidopsis thaliana." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112188/document.

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Porteur redox intervenant dans nombre de processus métaboliques, le NAD (nicotinamide adénine dinucléotide) est central pour les cellules vivantes. Outre son importance dans le métabolisme oxydoréductif, des données récentes suggèrent fortement d’autres rôles importants pour le NAD dans la signalisation cellulaire. Un système inductible d’enrichissement en NAD en surproduisant la quinolinate phosphoribosyltransférase (QPT) d’Escherichia coli chez Arabidopsis thaliana a permis de mettre en évidence l’implication du NAD dans les mécanismes spécifiques de défenses qui régissent les interactions p

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Ramakrishnan, Sathiya. "Structural, functional and evolutionary studies on 6-oxopurine phosphoribosyltransferases (PRTases) /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16106.pdf.

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Neris, Débora Meira. "Efeito da imunização com enzimas recombinantes do metabolismo de nucleotídeos de Schistosoma mansoni sobre o desenvolvimento da esquistossomose mansônica experimental." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/7018.

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Made available in DSpace on 2016-08-17T18:39:46Z (GMT). No. of bitstreams: 1 5245.pdf: 1568165 bytes, checksum: 9fc25ff9dc83339e50628c08854efd2c (MD5) Previous issue date: 2012-08-29<br>Universidade Federal de Sao Carlos<br>Schistosimiasis mansoni is a neglected chronic parasitic disease that affects thousands of people worldwide, caused by the trematode Schistosoma mansoni. In the infected host the disease is characterized by the presence of granuloma, imunnopathological response of the cellular infiltration against egg antigens. Thus, the host-parasite relation favors hepatosplenomegaly, a

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Yu-ChingKo and 柯兪靖. "Nicotinamide Phosphoribosyltransferase (NAMPT) expression in Periodontitis and Peri-implantitis." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/kb99jn.

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Campbell, Elizabeth. "Nicotinamide phosphoribosyltransferase interaction with polyphenolic modulator in the presence of ATP." Thesis, 2019. https://hdl.handle.net/2144/36172.

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Nicotinamide adenine dinucleotide (NAD) is critical in human physiology, the molecule is part of redox reactions vital to metabolism and it is a substrate for multiple signaling proteins in the body. During times of stress in the body, which if chronic can lead to lifelong illness, NAD consumption by signaling proteins is increased and NAD concentration can be depleted. Age related illnesses are often the result of compounding stresses placed on the body over time. A novel way to approach understanding age-related illness, such as diabetes type II and neurodegenerative diseases, is through inv

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Chen, Shiu-Min, and 陳秀敏. "The study of relationship between hypoxanthine-guanine phosphoribosyltransferase activity and gout or uric acid." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/02530974026597526444.

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碩士<br>高雄醫學大學<br>公共衛生學研究所<br>89<br>Abstract There are two aboriginal tribes (Bunun, Paiwan) and one non-aboriginal tribe (Fukien-Taiwan) included as the study population. The subjects were used to explore the relationship between the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) and gout disease or uric acid level. Comparison the difference of HPRT activity between aborigines and non-aborigines and the related factors are the study major aims. A total of 172 samples included in this study. A questionnaire was completed by the subjects to obtain the soc

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Schwab, Thomas [Verfasser]. "Zusammenhang zwischen Quartärstruktur, Stabilität und katalytischer Aktivität am Beispiel der Anthranilat-Phosphoribosyltransferase / vorgelegt von Thomas Schwab." 2010. http://d-nb.info/1008881627/34.

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Deuß, Miriam [Verfasser]. "Untersuchungen zur Struktur, Funktion und Dynamik der Anthranilat-Phosphoribosyltransferase aus Sulfolobus solfataricus / vorgelegt von Miriam Deuß." 2007. http://d-nb.info/984762493/34.

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Wang, Chiung-Pei, and 王瓊珮. "Mutation Spectra Induced by Safrole in Hypoxanthine-guanine Phosphoribosyltransferase Locus of Chinese Hamster Ovary K1 Cells." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/93030672516238781842.

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碩士<br>國立陽明大學<br>藥理學研究所<br>88<br>Safrole, an essential oil that has been used in cosmetics and as a food flavoring agents, is classified as a rodent hepatocarcinogen. The carcinogenicity of safrole is mediated through 1'-hydroxysafrole formation, sulfonated to an unstable sulfuric acid ester, and consequently forming stable safrole-DNA adducts. DNA adduct is known to be an initial step of mutagenesis and carcinogenesis. In Taiwan, Piper betle inflorescence contains high concentration of safrole (15 mg/g fresh weight), and may contribute to human exposure (420 microM of safrole in saliva) whil

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Lorenz, Veronika [Verfasser]. "Komplexe Veränderungen in der Genexpression der Ecto-Nukleosid-5'-Triphosphat-Diphosphohydrolase bei Hypoxanthin-Phosphoribosyltransferase-Defizienz / vorgelegt von Veronika Lorenz." 2009. http://d-nb.info/993681751/34.

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Do, Hong-Hai, and Erhard Rahm. "Flexible Integration of Molecular-Biological Annotation Data: The GenMapper Approach." 2004. https://ul.qucosa.de/id/qucosa%3A32457.

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Molecular-biological annotation data is continuously being collected, curated and made accessible in numerous public data sources. Integration of this data is a major challenge in bioinformatics. We present the GenMapper system that physically integrates heterogeneous annotation data in a flexible way and supports large-scale analysis on the integrated data. It uses a generic data model to uniformly represent different kinds of annotations originating from different data sources. Existing associations between objects, which represent valuable biological knowledge, are explicitly utilized to dr

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Xie, Fu-Bin, and 謝富彬. "Effect of O6-alkylguaninetransferase on the mutational spectrum induced by N-methyl-N?nitro-N-nitrosoguanidine in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase in Chinese hamster ovary cells." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/79164470862931025267.

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