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Artykuły w czasopismach na temat „Photo-uncaging”

Autor: Grafiati

Data publikacji: 14 września 2024

Data aktualizacji: 31 lipca 2025

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1

Perdue, Lacey A., Priscilla Do, Andrew Chyong, et al. "Chemical modification strategies for photo-induced control of immune cell signaling." Journal of Immunology 204, no. 1_Supplement (2020): 221.1. http://dx.doi.org/10.4049/jimmunol.204.supp.221.1.

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Abstract Cytokine therapies show great potential to induce cancer immune elimination and have demonstrated therapeutic benefit in a subset of patients. However, controlling the pleotropic effects of these immune signal effectors is a challenge. Here, we present an approach to enable optical control of cytokine activity by caging the activity of these proteins via labeling with wavelength-specific, photo-labile polymers (i.e. photo-caging). We create a system to measure light-induced polymer cleavage (uncaging) through fluorescence dequenching and establish: high wavelength-selectivity, protein

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Sambath, Karthik, Tinghan Zhao, Zhaoxiong Wan, and Yuanwei Zhang. "Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells." Chemical Communications 55, no. 94 (2019): 14162–65. http://dx.doi.org/10.1039/c9cc07199g.

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Ford, Peter C., Issa Frigino, James R. Tinsley, and John A. DiBenedetto. "Coupling nitric oxide photo-uncaging with radiotherapy." Coordination Chemistry Reviews 535 (July 2025): 216630. https://doi.org/10.1016/j.ccr.2025.216630.

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Ichimura, Hideo, Kaushik Parthasarathi, Jens Lindert, and Jahar Bhattacharya. "Lung surfactant secretion by interalveolar Ca2+ signaling." American Journal of Physiology-Lung Cellular and Molecular Physiology 291, no. 4 (2006): L596—L601. http://dx.doi.org/10.1152/ajplung.00036.2006.

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Although clusters of alveoli form the acinus, which is the most distal respiratory unit, it is not known whether interalveolar communication coordinates acinar surfactant secretion. To address this, we applied real-time digital imaging in conjunction with photo-excited Ca2+ uncaging in intact alveoli of the isolated, blood-perfused rat lung. We loaded alveolar cells with the Ca2+ cage o-nitrophenyl EGTA-AM (NP-EGTA-AM) together with the fluorophores, fluo 4, or LysoTracker green (LTG) to determine, respectively, the cytosolic Ca2+ concentration ([Ca2+]cyt) or type 2 cell secretion. To uncage C

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Wang, Haopei, and Zachary T. Ball. "A photochemical C=C cleavage process: toward access to backbone N-formyl peptides." Beilstein Journal of Organic Chemistry 17 (December 15, 2021): 2932–38. http://dx.doi.org/10.3762/bjoc.17.202.

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Photo-responsive modifications and photo-uncaging concepts are useful for spatiotemporal control of peptides structure and function. While side chain photo-responsive modifications are relatively common, access to photo-responsive modifications of backbone N–H bonds is quite limited. This letter describes a new photocleavage pathway, affording N-formyl amides from vinylogous nitroaryl precursors under physiologically relevant conditions via a formal oxidative C=C cleavage. The N-formyl amide products have unique properties and reactivity, but are difficult or impossible to access by traditiona

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6

de Sousa, Aurideia P., Ana C. S. Gondim, Eduardo H. S. Sousa, et al. "An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity." JBIC Journal of Biological Inorganic Chemistry 25, no. 3 (2020): 419–28. http://dx.doi.org/10.1007/s00775-020-01772-5.

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Lee, Shin-Rong, Paul J. Adams, and David T. Yue. "Large Ca2+-dependent facilitation of CaV2.1 channels revealed by Ca2+photo-uncaging." Journal of Physiology 593, no. 13 (2015): 2753–78. http://dx.doi.org/10.1113/jp270091.

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8

Rong Lee, Shin, Manu B. Johny, and David T. Yue. "Large Ca2+-Dependent Facilitation of CaV2.1 Channels Induced by Ca2+ Photo-Uncaging." Biophysical Journal 104, no. 2 (2013): 461a. http://dx.doi.org/10.1016/j.bpj.2012.11.2549.

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Höglinger, Doris, André Nadler, Per Haberkant, et al. "Trifunctional lipid probes for comprehensive studies of single lipid species in living cells." Proceedings of the National Academy of Sciences 114, no. 7 (2017): 1566–71. http://dx.doi.org/10.1073/pnas.1611096114.

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Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid−protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo–cross-linking in a sequential manner, as well as a click-handle for subsequent functionalization. We demonstrat

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10

Leonidova, Anna, Vanessa Pierroz, Riccardo Rubbiani, et al. "Photo-induced uncaging of a specific Re(i) organometallic complex in living cells." Chemical Science 5, no. 10 (2014): 4044. http://dx.doi.org/10.1039/c3sc53550a.

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Pickens, Rachael N., Grace L. Judd, and Jessica K. White. "Photo-uncaging a Ru(ii) intercalator via photodecomposition of a bridged Mn(i) photoCORM." Chemical Communications 57, no. 62 (2021): 7713–16. http://dx.doi.org/10.1039/d1cc02371c.

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Carling, Carl-Johan, Jason Olejniczak, Alexandra Foucault-Collet, et al. "Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles." Chemical Science 7, no. 3 (2016): 2392–98. http://dx.doi.org/10.1039/c5sc03717d.

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13

Wang, Yan, Shuai Li, Zhenyu Tian, et al. "Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction." Nucleic Acids Research 47, no. 19 (2019): e114-e114. http://dx.doi.org/10.1093/nar/gkz659.

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Abstract Application of viral vectors in gene delivery is attracting widespread attention but is hampered by the absence of control over transduction, which may lead to non-selective transduction with adverse side effects. To overcome some of these limitations, we proposed an unnatural amino acid aided caging–uncaging strategy for controlling the transduction capability of a viral vector. In this proof-of-principle study, we first expanded the genetic code of the lentiviral vector to incorporate an azido-containing unnatural amino acid (Nϵ-2-azidoethyloxycarbonyl-l-lysine, NAEK) site specifica

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14

Ford, Peter C. "Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide." Coordination Chemistry Reviews 376 (December 2018): 548–64. http://dx.doi.org/10.1016/j.ccr.2018.07.018.

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15

Horinouchi, Taeko, Hidehiko Nakagawa, Takayoshi Suzuki, Kiyoshi Fukuhara, and Naoki Miyata. "A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide." Bioorganic & Medicinal Chemistry Letters 21, no. 7 (2011): 2000–2002. http://dx.doi.org/10.1016/j.bmcl.2011.02.027.

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16

Dai, Ziwen, and Zhigang Wang. "Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action." Molecules 25, no. 21 (2020): 5167. http://dx.doi.org/10.3390/molecules25215167.

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Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of acti

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17

Iwamoto, Yuji, Masahito Kodera, and Yutaka Hitomi. "Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex." Chemical Communications 51, no. 46 (2015): 9539–42. http://dx.doi.org/10.1039/c5cc02566d.

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18

Schöneberg, Johannes, Mark Remec Pavlin, Shannon Yan, et al. "ATP-dependent force generation and membrane scission by ESCRT-III and Vps4." Science 362, no. 6421 (2018): 1423–28. http://dx.doi.org/10.1126/science.aat1839.

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The endosomal sorting complexes required for transport (ESCRTs) catalyze reverse-topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways. We encapsulated ESCRT-III subunits Snf7, Vps24, and Vps2 and the AAA+ ATPase (adenosine triphosphatase) Vps4 in giant vesicles from which membrane nanotubes reflecting the correct topology of scission could be pulled. Upon ATP release by photo-uncaging, this system generated forces within the nanotubes that led to membrane scission in a manner dependent upon Vps4 catalytic ac

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19

Zheng, Yang, Meichun Gao, Maikel Wijtmans, Henry F. Vischer, and Rob Leurs. "Synthesis and Pharmacological Characterization of New Photocaged Agonists for Histamine H3 and H4 Receptors." Pharmaceuticals 17, no. 4 (2024): 536. http://dx.doi.org/10.3390/ph17040536.

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The modulation of biological processes with light-sensitive chemical probes promises precise temporal and spatial control. Yet, the design and synthesis of suitable probes is a challenge for medicinal chemists. This article introduces a photocaging strategy designed to modulate the pharmacology of histamine H3 receptors (H3R) and H4 receptors (H4R). Employing the photoremovable group BODIPY as the caging entity for two agonist scaffolds—immepip and 4-methylhistamine—for H3R and H4R, respectively, we synthesized two BODIPY-caged compounds, 5 (VUF25657) and 6 (VUF25678), demonstrating 10–100-fol

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20

van Rixel, Vincent H. S., Vadde Ramu, Austin B. Auyeung, et al. "Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model." Journal of the American Chemical Society 141, no. 46 (2019): 18444–54. http://dx.doi.org/10.1021/jacs.9b07225.

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Schuhmacher, Milena, Andreas T. Grasskamp, Pavel Barahtjan, et al. "Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 7729–38. http://dx.doi.org/10.1073/pnas.1912684117.

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Every cell produces thousands of distinct lipid species, but insight into how lipid chemical diversity contributes to biological signaling is lacking, particularly because of a scarcity of methods for quantitatively studying lipid function in living cells. Using the example of diacylglycerols, prominent second messengers, we here investigate whether lipid chemical diversity can provide a basis for cellular signal specification. We generated photo-caged lipid probes, which allow acute manipulation of distinct diacylglycerol species in the plasma membrane. Combining uncaging experiments with mat

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22

Boucsein, Clemens, Martin Nawrot, Stefan Rotter, Ad Aertsen, and Detlef Heck. "Controlling Synaptic Input Patterns In Vitro by Dynamic Photo Stimulation." Journal of Neurophysiology 94, no. 4 (2005): 2948–58. http://dx.doi.org/10.1152/jn.00245.2005.

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Recent experimental and theoretical work indicates that both the intensity and the temporal structure of synaptic activity strongly modulate the integrative properties of single neurons in the intact brain. However, studying these effects experimentally is complicated by the fact that, in experimental systems, network activity is either absent, as in the acute slice preparation, or difficult to monitor and to control, as in in vivo recordings. Here, we present a new implementation of neurotransmitter uncaging in acute brain slices that uses functional projections to generate tightly controlled

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Jervis, Peter J., Loic Hilliou, Renato B. Pereira, David M. Pereira, José A. Martins, and Paula M. T. Ferreira. "Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel." Nanomaterials 11, no. 3 (2021): 704. http://dx.doi.org/10.3390/nano11030704.

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Short peptides capped on the N-terminus with aromatic groups are often able to form supramolecular hydrogels, via self-assembly, in aqueous media. The rheological properties of these readily tunable hydrogels resemble those of the extracellular matrix (ECM) and therefore have potential for various biological applications, such as tissue engineering, biosensors, 3D bioprinting, drug delivery systems and wound dressings. We herein report a new photo-responsive supramolecular hydrogel based on a “caged” dehydropeptide (CNB-Phe-ΔPhe-OH 2), containing a photo-cleavable carboxy-2-nitrobenzyl (CNB) g

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24

Frank, J. G., H. S. Jameson, C. Gorini, and D. Mendelowitz. "Mapping and Identification of GABAergic Neurons in Transgenic Mice Projecting to Cardiac Vagal Neurons in the Nucleus Ambiguus Using Photo-Uncaging." Journal of Neurophysiology 101, no. 4 (2009): 1755–60. http://dx.doi.org/10.1152/jn.91134.2008.

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The neural control of heart rate is determined primarily by the activity of preganglionic parasympathetic cardiac vagal neurons (CVNs) originating in the nucleus ambiguus (NA) in the brain stem. GABAergic inputs to CVNs play an essential role in determining the activity of these neurons including a robust inhibition during each inspiratory burst. The origin of GABAergic innervation has yet to be determined however. A transgenic mouse line expressing green florescent protein (GFP) in GABAergic cells was used in conjunction with caged glutamate to identify both clusters and individual GABAergic

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25

Chatterjee, Tanmay, Debjit Roy, Ananya Das, Anup Ghosh, Partha Pratim Bag, and Prasun K. Mandal. "Chemical tweaking of a non-fluorescent GFP chromophore to a highly fluorescent coumarinic fluorophore: application towards photo-uncaging and stem cell imaging." RSC Advances 3, no. 46 (2013): 24021. http://dx.doi.org/10.1039/c3ra44034f.

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Limpitikul, Worawan B., Joseph L. Greenstein, David T. Yue, Ivy E. Dick, and Raimond L. Winslow. "A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels." Journal of General Physiology 150, no. 12 (2018): 1688–701. http://dx.doi.org/10.1085/jgp.201812115.

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L-type calcium channels (LTCCs) are critical elements of normal cardiac function, playing a major role in orchestrating cardiac electrical activity and initiating downstream signaling processes. LTCCs thus use feedback mechanisms to precisely control calcium (Ca2+) entry into cells. Of these, Ca2+-dependent inactivation (CDI) is significant because it shapes cardiac action potential duration and is essential for normal cardiac rhythm. This important form of regulation is mediated by a resident Ca2+ sensor, calmodulin (CaM), which is comprised of two lobes that are each capable of responding to

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Jing, Zhixin, Mark J. McCarron, Michael L. Dustin, and David R. Fooksman. "Germinal center expansion but not plasmablast differentiation is directly proportional to peptide-MHCII density via CD40-CD40L signaling strength." Journal of Immunology 208, no. 1_Supplement (2022): 102.05. http://dx.doi.org/10.4049/jimmunol.208.supp.102.05.

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Abstract Although cognate peptide-MHCII (pMHCII) is critical for B cell selection in the germinal center (GC), it is unclear how cell intrinsic differences in peptide levels contribute to selection and cell fate decisions. Here, we applied the a-DEC205-OVA (dec) model system, to deliver different levels of OVA peptide to GC B cells in situ in order to interrogate how intermediate and high levels of pMHCII affect selection and cell fate on a per cell basis. We used Ly75+/− (DEC-het) B cells, which expressed ~50% of surface DEC205 protein compared to WT B cells, and presented proportional amount

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Korzycka, Karolina A., Philip M. Bennett, Eduardo Jose Cueto-Diaz, et al. "Two-photon sensitive protecting groups operating via intramolecular electron transfer: uncaging of GABA and tryptophan." Chemical Science 6, no. 4 (2015): 2419–26. http://dx.doi.org/10.1039/c4sc03775h.

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Wan, Zhaoxiong, Shupei Yu, Qi Wang, et al. "Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery." Journal of Materials Chemistry B, 2023. http://dx.doi.org/10.1039/d3tb01867a.

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Bramham, Jack E., Matja Zalar, and Alexander P. Golovanov. "Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy." Chemical Communications, 2022. http://dx.doi.org/10.1039/d2cc04731d.

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Klausen, Maxime, Victor Dubois, Sébastien Picard, et al. "Click Synthesis of Tweezer Dyads for H‐Bond Assisted Cooperativity in Tandem Uncaging Systems." Chemistry – A European Journal, July 2024. http://dx.doi.org/10.1002/chem.202402076.

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Abstract: “Tandem” uncaging systems, in which a photolabile protecting group (PPG) is sensitized by an energy‐harvesting antenna, may increase the photosensitivity of PPGs by several orders of magnitude for two‐photon (2P) photorelease. Yet, they remain poorly accessible because of arduous multi‐step synthesis. In this work, we design efficient tandem uncaging systems by (i) using a convenient assembly of the building blocks relying on click chemistry, (ii) H‐bonding induced proximity thus facilitating (iii) photoinduced electron transfer (PeT) as a cooperative mechanism. A strong two‐photon a

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Denninger, L., H. Brunst, L. J. G. W. van Wilderen, et al. "Switch the click: Ultrafast photochemistry of photoDIBO-OH tracked by time-resolved IR spectroscopy." Journal of Chemical Physics 160, no. 17 (2024). http://dx.doi.org/10.1063/5.0196923.

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Click chemistry refers to selective reactions developed for grafting of bio(macro)molecules in their biological media. Caged click compounds have been employed to spatiotemporally control click reactions. Here, we survey the uncaging of photo-dibenzocyclooctyne-OH (photoDIBO-OH) to its click-chemistry active form DIBO-OH, with particular attention to its conversion timescale and efficiency. Ultraviolet pump–infrared probe experiments reveal a stepwise decarbonylation: first, carbon monoxide (C≡O) is released within 1.8 ps, and then, it converts, within 10 ps, to DIBO-OH. Completion of uncaging

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Kalayci, Kubra, Hendrik Frisch, Christopher Barner-Kowollik, and Vinh X. Truong. "Green Light Enabled Staudinger-Bertozzi Ligation." Chemical Communications, 2022. http://dx.doi.org/10.1039/d2cc00911k.

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We introduce a visible light-induced Staudinger-Bertozzi ligation via photo-uncaging of a triphenylphosphine moiety with a photolabile coumarin derivative. Our action plot study examines the conversion as the function of wavelength,...

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Zhang, Yidan, Yixin Zhang, Lili Han, et al. "Photo‐Modulation of Gene‐Editing Enzymes CRISPR/Cas9 with Bifunctional Small‐Molecule Ligands." Chinese Journal of Chemistry, September 13, 2023. http://dx.doi.org/10.1002/cjoc.202300452.

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Comprehensive SummaryThe control of protein functions with light is valuable for spatiotemporal probing of biological systems. Current photo‐modulation methods include the light‐induced small‐molecule inhibitors uncaging and chromophore‐assisted light inactivation with reactive oxygen species (ROS). However, constant target protein expression results in inadequate photo‐modulation efficiency, particularly for less potent inhibitors and chromophores. Herein, we report a novel bifunctional small‐molecule ligands strategy to photo‐modulate gene‐editing enzymes CRISPR/Cas9. A coumarin‐derived smal

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Morgante, Pierpaolo, Charitha Guruge, Yannick P. Ouedraogo, Nasri Nesnas, and Roberto Peverati. "Competition between cyclization and unusual Norrish type I and type II nitro-acyl migration pathways in the photouncaging of 1-acyl-7-nitroindoline revealed by computations." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-79701-4.

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AbstractThe 7-nitroindolinyl family of caging chromophores has received much attention in the past two decades. However, its uncaging mechanism is still not clearly understood. In this study, we performed state-of-the-art density functional theory calculations to unravel the photo-uncaging mechanism in its entirety, and we compared the probabilities of all plausible pathways. We found competition between a classical cyclization and an acyl migration pathway, and here we explain the electronic and steric reasons behind such competition. The migration mechanism possesses the characteristics of a

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Höglinger, Doris, Per Haberkant, Auxiliadora Aguilera-Romero, et al. "Intracellular sphingosine releases calcium from lysosomes." eLife 4 (November 27, 2015). http://dx.doi.org/10.7554/elife.10616.

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To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous elevation of intracellular Sph levels via caged Sph leads to a significant and transient calcium release from acidic stores that is independent of sphingosine 1-phosphate, extracellular and ER calcium levels. This photo-induced Sph-driven calcium release requires the two-pore channel 1 (TPC1) residing on endosomes and lysosomes. Further, uncaging of Sph leads to the translocation of the autophagy-relevant transcription factor EB (TFEB) to the nucleus specifically after lysosomal calcium release. We confirm tha

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"Photo-Uncaging of a Microtubule Depolymerizer Reduces Tumor Volume in a Mouse Model." Synfacts 20, no. 03 (2024): 0321. http://dx.doi.org/10.1055/s-0043-1773076.

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Hudson, Elyse, Christabel Faylinn, Ivonne Rebeca Lopez-Miranda, Josh Milstein та Andrew Beharry. "Antimicrobial Efficacy of Photocaged β‐lapachone in Bacillus subtilis Biofilms". ChemPhotoChem, 26 червня 2024. http://dx.doi.org/10.1002/cptc.202400164.

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With the rise of antibiotic resistance within clinical settings, combating the growth of microbial biofilms presents a unique challenge. Biofilm‐inhabiting bacteria are embedded within a self‐produced, protective matrix, which can reduce the efficacy of treatment. The naturally derived product β‐lapachone is an appealing therapeutic agent that has been reported to inhibit biofilm growth. However, its off‐target toxicity and poor metabolic stability pose a significant hurdle for its application in vivo. Using a photo‐pharmacological approach via a coumarin‐based photocage, the reactivity of β‐l

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Maller, Corina, Eirini Marouda, and Maja Köhn. "Photo‐Claisen Rearrangement in a Coumarin‐Caged Peptide leads to a Surprising Enzyme Hyperactivation." ChemBioChem, August 22, 2024. http://dx.doi.org/10.1002/cbic.202400561.

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Protein phosphatase‐1 (PP1) is a ubiquitous enzyme counteracting hundreds of kinases in cells. PP1 interacts with regulatory proteins via an RVxF peptide motif that binds to a hydrophobic groove on the enzyme. PP1‐disrupting peptides (PDPs) compete with these regulatory proteins, leading to the release of the active PP1 subunit and promoting substrate dephosphorylation. Building on previous strategies employing the ortho‐nitrobenzyl (o‐Nb) group, we introduced coumarin derivatives into a PDP via an ether bond to explore their effects on PP1 activity. Surprisingly, our study revealed that the c

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Schulte, Albert Marten, Lianne M. Smid, Georgios Alachouzos, Wiktor Szymanski, and Ben L. Feringa. "Cation delocalization and photo-isomerization enhance the uncaging quantum yield of a photocleavable protecting group." Chemical Communications, 2024. http://dx.doi.org/10.1039/d3cc05055f.

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Sinha, Ghanshyam P., and Gregory I. Frolenkov. "Regulation of cochlear hair cell function by intracellular calcium stores." Frontiers in Cellular Neuroscience 18 (November 25, 2024). http://dx.doi.org/10.3389/fncel.2024.1484998.

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IntroductionMammalian hearing depends on the dual mechanosensory and motor functions of cochlear hair cells. Both these functions may be regulated by Ca2+ release from intracellular stores. However, it is still unclear how exactly intracellular Ca2+ release may affect either hair cell mechano-electrical transduction (MET) or prestin-dependent electromotility in outer hair cells (OHCs).MethodsHere, we used photo-activatable (caged) compounds to generate fast increases of either Ca2+ or inositol-3-phosphate (IP3) in the cytosol of young postnatal rodent auditory hair cells, thereby stimulating e

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Zheng, Ying, Zhiwei Ye, Xue Zhang, and Yi Xiao. "Photo-uncaging Triggers on Self-Blinking to Control Single-Molecule Fluorescence Kinetics for Super-resolution Imaging." ACS Nano, June 28, 2024. http://dx.doi.org/10.1021/acsnano.4c03809.

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Xie, Lina, Zhuoli Chen, Tianying Wang, et al. "Photo-Uncaging of a Ferrocene-Bridged Dinuclear Iridium(III) Complex for Three-Photon Photoimmunotherapy against Hypoxic Melanoma†." Chemical Science, 2025. https://doi.org/10.1039/d5sc04006j.

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The complexity of solid tumors in light scattering, oxygen insufficiency, and redox imbalance complicates the strategic design of photoactivated therapy. In this work, an unprecedented photoactivated homolysis process of ferrocene...

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Otopalik, Adriane G., Alexander C. Sutton, Matthew Banghart, and Eve Marder. "When complex neuronal structures may not matter." eLife 6 (February 6, 2017). http://dx.doi.org/10.7554/elife.23508.

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Much work has explored animal-to-animal variability and compensation in ion channel expression. Yet, little is known regarding the physiological consequences of morphological variability. We quantify animal-to-animal variability in cable lengths (CV = 0.4) and branching patterns in the Gastric Mill (GM) neuron, an identified neuron type with highly-conserved physiological properties in the crustacean stomatogastric ganglion (STG) of Cancer borealis. We examined passive GM electrotonic structure by measuring the amplitudes and apparent reversal potentials (Erevs) of inhibitory responses evoked

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Chattopadhayay, Sandip, Kshitij V. Banzal, and Pinaki Talukdar. "Photo‐activation of Tolane‐based Synthetic Ion Channel for Transmembrane Chloride Transport." Angewandte Chemie, September 9, 2024. http://dx.doi.org/10.1002/ange.202414354.

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While natural channels respond to external stimuli to regulate ion concentration across cell membranes, creating a synthetic version remains challenging. Here, we present a photo‐responsive uncaging technique within an artificial ion channel system, which activates the ion transport process from a transport‐inactive o‐nitrobenzyl‐based caged system. From the comparative ion transport screening, 1b emerged as the most active transporter. Interestingly, its bis(o‐nitrobenzyl) derivative, i.e., protransporter 1b' was inefficient in transporting ions. Detailed transport studies indicated that comp

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Chattopadhayay, Sandip, Kshitij V. Banzal, and Pinaki Talukdar. "Photo‐activation of Tolane‐based Synthetic Ion Channel for Transmembrane Chloride Transport." Angewandte Chemie International Edition, September 9, 2024. http://dx.doi.org/10.1002/anie.202414354.

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While natural channels respond to external stimuli to regulate ion concentration across cell membranes, creating a synthetic version remains challenging. Here, we present a photo‐responsive uncaging technique within an artificial ion channel system, which activates the ion transport process from a transport‐inactive o‐nitrobenzyl‐based caged system. From the comparative ion transport screening, 1b emerged as the most active transporter. Interestingly, its bis(o‐nitrobenzyl) derivative, i.e., protransporter 1b' was inefficient in transporting ions. Detailed transport studies indicated that comp

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Sharma, Arpit, Wjdan Jogadi, Man Kshetri, et al. "Click-Controlled Photo-Uncaging: Click-Assembly of Platinum-Based Photoactive Protecting Groups for Light-Triggered Bioactive Molecule Release." Journal of the American Chemical Society, June 3, 2025. https://doi.org/10.1021/jacs.5c02579.

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Chen, Lujing, Guang Li, Zheng Jiang, and King-Wai Yau. "Unusual phototransduction via cross-motif signaling from G _q to adenylyl cyclase in intrinsically photosensitive retinalganglion cells." Proceedings of the National Academy of Sciences 120, no. 1 (2022). http://dx.doi.org/10.1073/pnas.2216599120.

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Nonimage-forming vision in mammals is mediated primarily by melanopsin (OPN4)-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). In mouse M1-ipRGCs, melanopsin predominantly activates, via Gα q,11,14 , phospholipase C-β4 to open transient receptor 6 (TRPC6) and TRPC7 channels. In M2- and M4-ipRGCs, however, a prominent phototransduction mechanism involves the opening of hyperpolarization- and cyclic nucleotide-gated channels via cyclic nucleotide, although the upstream steps remain uncertain. We report here experiments, primarily on M4-ipRGCs, with photo-uncaging of cycl

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Hashimoto, Ryu, Masafumi Minoshima, and Kazuya Kikuchi. "Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light‐Triggered DNA Recombination." ChemBioChem, December 28, 2023. http://dx.doi.org/10.1002/cbic.202300799.

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The precise control of DNA recombination enables the cell‐ or time‐dependent regulation of gene expression in studies of gene function. Caged estrogen receptor ligands combined with a Cre‐ERT2/loxP system are useful tools for light‐triggered DNA recombination. However, the photolysis of most caged compounds requires ultraviolet or blue light, which is toxic and displays low tissue penetration. Although a cyanine‐based photo‐responsive protecting group (PPG) can release estrogen receptor ligands with longer‐wavelength light, its low photolytic efficiency requires long illumination times. We dev

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Valera, Jorge S., Álvaro López-Acosta, and Thomas Hermans. "Photoinitiated Transient Self‐Assembly in a Catalytically Driven Chemical Reaction Cycle." Angewandte Chemie International Edition, May 21, 2024. http://dx.doi.org/10.1002/anie.202406931.

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Chemically‐fueled chemical reaction networks (CRNs) are key in controlling dissipative self‐assembly. A key challenge in the field is to store chemical fuel‐precursors or “pre‐fuels” in the system that are catalytically converted into activating or deactivating fuels that drive the CRN. In addition, real‐time control over such catalysis by light is highly desirable, but so far not yet achieved. Here we show a catalytically‐driven CRN that is photoinitiated with 450 nm light, producing activated monomers that go on to perform transient self‐assembly. Monomer activation proceeds via photoredox c

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