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Data publikacji: 6 września 2023

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1

Maheshwari, Sweta. "Caractérisation biochimique et cellulaire des enzymes clés du métabolisme des phospholipides chez Plasmodium falciparum." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20004.

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Le développement du parasite Plasmodium falciparum, responsable du paludisme, nécessite la synthèse de phospholipides et plus particulièrement de phosphatidylcholine (PC) et phosphaditylethanolamine (PE) qui représentent environ 85% de la totalité des phospholidipes du parasite. Leur synthèse s'effectue principalement par les voies métaboliques de novo, voies de Kennedy, en trois étapes enzymatiques. Les enzymes CTP: phosphoethanolamine cytidylyltransferase (ECT) et CTP: phosphocholine cytidylyltransferase (CCT) catalysent les étapes limitantes des deux voies de biosynthèse de la PE et de la P

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Higham, Christopher W. "A study of lactate dehydrogenase from Plasmodium falciparum." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299529.

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Shoemark, Deborah Karen. "The kinetic characterization of the lactate dehydrogenase enzyme from Plasmodium falciparum." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326677.

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4

Birkholtz, Lyn-Marie. "Functional and structural characterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-06302005-120320/.

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Birkholtz, Lyn-Marie. "Functional and structural charaterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Thesis, University of Pretoria, 2001. http://hdl.handle.net/2263/25944.

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Malaria remains one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapies. The need for novel therapeutic targets and drugs is therefore of the utmost importance and detailed knowledge of the biochemistry of the parasite is imperative. This study was directed at the biochemical characterisation of the polyamine metabolic pathway of P. falciparum in order to elucidate differences between the parasite and its human host that can be exploited in the design of novel antim

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Turgut, Dilek. "Overproduction of the active lactate dehydrogenase from Plasmodium falciparum opens a route to obtain new antimalarials." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389088.

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7

Ko, Reamonn, and 高耀駿. "X-ray crystallographic studies of Plasmodium falciparum adenylate kinases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208020.

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Malaria is a global health concern accounting for approximately 219 million cases and an estimated 660 000 deaths in 2010. The most fatal strain of malarial parasite, Plasmodium falciparum is found to contain 3 Adenylate Kinases (PfAK1, PfAK2 and PfGAK). Adenylate Kinases are important enzymes that essentially catalyze and regulate energy metabolism processes. PfAK1 and PfAK2 catalyze the reversible MG2+ reaction ATP + AMP ←→ 2ADP whereas, the PfGAK catalyzes the Mg2+ dependent reaction GTP+AMP ←→ ADP+GDP. Of all malarial strains, only the Plasmodium falciparum Adenylate Kinase 2 (PfAK2) was f

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8

Yao, Jia. "Synthesis of silver nanoparticles and their role against a thiazolekinase enzyme from Plasmodium falciparum." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020894.

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Malaria, a mosquito-borne infectious disease, caused by the protozoan Plasmodium genus, is the greatest health challenges worldwide. The plasmodial vitamin B1 biosynthetic enzyme PfThzK diverges significantly, both structurally and functionally from its counterpart in higher eukaryotes, thereby making it particularly attractive as a biomedical target. In the present study, PfThzK was recombinantly produced as 6×His fusion protein in E. coli BL21, purified using nickel affinity chromatography and size exclusion chromatography resulting in 1.03% yield and specific activity 0.28 U/mg. The enzyme

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9

Khairallah, Afrah. "The identification of natural inhibitory compounds against the plasmodium GTP Cyclohydrolase I (GCH1) enzyme." Thesis, Rhodes University, 2019. http://hdl.handle.net/10962/72284.

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Malaria is a disease caused by protozoan parasites that invade red blood cells causing an infection. Malaria remains a global health problem. The genus Plasmodium infects about a quarter of a billion people annually, resulting in over a million death cases. This can severely affect the public health and socioeconomic development especially in countries with limited resources. Malaria is transmitted by the female Anopheles mosquito. Five species within the Plasmodium genus are known to cause infection in humans; namely Plasmodium falciparum, Plasmodium Ovale, Plasmodium knowlesi, Plasmodium viv

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10

Goolab, Shivani. "Optimization of the heterologous expression of folate metabolic enzymes of Plasmodium falciparum." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/23647.

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Malaria is a fatal tropical disease affecting billions of people in impoverished countries world-wide. An alarming fact is that a child in Africa dies of malaria every 30 seconds that amounts to 2500 children per day (www.who.int/features/factfiles). Malaria is caused by the intraerythrocytic forms of Plasmodium species, notably P. falciparum, P. vivax, P. ovale and P. malariae (Hyde 2007). The spread of drug-resistant strains, failure of vector control programs, rapid growth rate of the parasite, and lack of a vaccine have further exacerbated the effects of malaria on economic development and

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11

Contet, Alicia. "Caractérisation biochimique et biophysique des deux cytidylyltransférases de Plasmodium falciparum, enzymes clés du métabolisme des phospholipides." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS085.

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Le paludisme est causé par l'infection et la destruction des érythrocytes par les parasites protozoaires appartenant au genre Plasmodium. Au cours de son développement dans l'érythrocyte,Plasmodium falciparum requiert la biosynthèse massive de membranes dont les principaux constituants lipidiques sont des phospholipides. La phosphatidylcholine (PC) et la phosphatidyléthanolamine (PE) représentent à elles deux environ 80 % des lipides membranaires et l'inhibition de leur biosynthèse est létale pour le parasite. La PC et la PE sont synthétisées par le parasite, principalement via les voies de no

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12

Goble, Jessica Leigh. "The druggable antimalarial target 1-deoxy-D-xylulose-5-phosphate reductoisomerase: purfication, kinetic characterization and inhibition studies." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004008.

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Plasmodium falciparum 1–deoxy–D–xylulose–5 phosphatereductoisomerase (PfDXR) plays a role in isoprenoid biosynthesis in the malaria parasite and is absent in the human host, making this parasite enzyme an attractive target for antimalarial drug design. To characterize PfDXR, it is necessary to produce large quantities of the enzyme in a soluble and functional form. However, the over–production of malarial proteins in prokaryotic host systems often results in the formation of truncated proteins or insoluble protein aggregates. A heterologous expression system was developed for the production of

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13

Tran, Thanh Nguyen. "Plasmodium Falciparum Histone Deacetylases as Novel Antimalarial Drug Targets." Thesis, Griffith University, 2010. http://hdl.handle.net/10072/367456.

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Histone deacetylases (HDACs) are recognised as potential drug targets for many diseases including cancer, inflammatory diseases and some parasitic diseases including malaria. In eukaryotic cells, these enzymes play an important role in transcriptional regulation through modification of chromatin structure. Inhibitors of mammalian HDAC enzymes including trichostain A and apicidin are active against P. falciparum parasites, however these compounds are not selective for malaria parasites versus normal cell lines. The aims of this study were to examine the antimalarial potential of new hydroxamate

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14

Njuguna, Joyce Njoki. "Structural analysis of prodomain inhibition of cysteine proteases in plasmodium species." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004081.

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Plasmodium is a genus of parasites causing malaria, a virulent protozoan infection in humans resulting in over a million deaths annually. Treatment of malaria is increasingly limited by parasite resistance to available drugs. Hence, there is a need to identify new drug targets and authenticate antimalarial compounds that act on these targets. A relatively new therapeutic approach targets proteolytic enzymes responsible for parasite‟s invasion, rupture and hemoglobin degradation at the erythrocytic stage of infection. Cysteine proteases (CPs) are essential for these crucial roles in the intraer

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15

Abd, Majid Roslaini. "Molecular and biochemical pharmacology of mitochondrial enzymes in the malaria parasite Plasmodium falciparum." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574668.

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The mitochondria of malaria have big potential to be explored as a drug targeting site. This is due to the differences in the composition of the Plasmodium respiratory complex compared with the human host. The Plasmodium respiratory chain consists of 2 unique dehydrogenases PfNDH2 and MQO which are only encoded in prokaryotic cells. Apart from these two, thy Plasmodium bc1 complex has low amino acid similarity when compared to the bc1 cQmplex of other eukaryotes. Currently the only approved antimalarial drug targeting Plasmodium mitochondria is atovaquone. This drug is used in combination with

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16

Southworth, Paul. "Quantitative proteomics of the human malaria parasite, Plasmodium falciparum, applied to folate biosynthetic enzymes." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/quantitative-proteomics-of-the-human-malaria-parasite-plasmodium-falciparum-applied-to-folate-biosynthetic-enzymes(3ba6c57f-3f37-443d-92d9-b255722e3f69).html.

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Human malaria caused by Plasmodium falciparum is a major global burden killing between 700,000 and 2.7 million people every year. Africa bears the greatest portion of this burden, with over three quarters of deaths occurring in African children, accounting for 18% of all child deaths in sub-Saharan Africa. Synthesis of tetrahydrofolate through the folate biosynthetic pathway is vital for the survival of P. falciparum parasites and is lacking in the human host. As such, enzymes of this pathway have long presented attractive targets for drug therapy and although increasingly being compromised by

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17

Engel, Jessica Alexandra. "Investigating Plasmodium falciparum Histone Deacetylase 1 Complex Proteins." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367801.

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Malaria causes substantial morbidity and mortality worldwide. Although there has been a considerable decline in global malaria incidence and mortality rates since 2000, it is estimated that more than 400,000 deaths occurred in 2015 as a result of this parasitic disease. The lack of a broadly effective licensed vaccine and the threat of malaria parasite resistance to current drugs means there is an urgent need for the development of new therapies with novel parasite targets. With a renewed call for global malaria eradication, novel therapeutic strategies are crucial to continue progress achieve

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18

Wang, Flora Yinglai-Hua. "Purification and Characterization of Native and Recombinant Dipeptidyl Aminopeptidase 1 of Plasmodium falciparum." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/42714.

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Plasmodium falciparum dipeptidyl aminopeptidase 1 (DPAP1) contributes to the degradation of hemoglobin by releasing dipeptides from globin oligopeptides in the food vacuole. The lack of success at DPAP1 gene disruption suggests that this exopeptidase is important for efficient growth during the erythrocytic asexual stage. DPAP1 is therefore an attractive target for the development of anti-malarial drugs that block the catabolism of hemoglobin. To guide the design of selective, potent DPAP1 inhibitors, it is necessary to characterize the substrate specificity of this enzyme along with its hum

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19

Gabriel, Heloisa Berti. "Caracterização funcional de farnesil difosfato sintase/geranilgeranil difosfato sintase (FPPS/GGPPS) e 1,4-dihidroxi-2-naftoato preniltransferase (MenA) envolvidas respectivamente na via de isoprenóides e da vitamina K em Plasmodium falciparum." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-22022016-153037/.

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A malária é uma das principais e a mais disseminada das parasitoses humanas. A falta de uma vacina eficaz e o problema da resistência aos fármacos tem contribuído para o adiamento da solução do controle desta infecção. A busca de novos alvos biológicos tem se concentrado, em parte, na compreensão de vias metabólicas. Em P. falciparum, identificamos a biossíntese das duas formas da vitamina K (filoquinona e menaquinona). Na via MEP foram caracterizadas duas importantes enzimas bifuncionais, a farnesil difosfato sintase/geranilgeranil difosfato sintase (FPPS/GGPPS) capaz de formar farnesil difos

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20

Pye, Matthew James. "Inhibiting Plasmodium falciparum IspD, a MEP pathway enzyme, as a novel target for the development of antimalarial chemotherapeutics." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3020589/.

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Reeksting, S. B. (Shaun Bernard). "Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof." Thesis, University of Pretoria, 2013. http://hdl.handle.net/2263/32965.

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Malaria is caused by the parasite Plasmodium falciparum and still plagues many parts of the world. To date, efforts to control the spread of the parasites have been largely ineffective. Due to development of resistance by the parasites to current therapeutics there is an urgent need for new classes of therapeutics. The vitamin B6 biosynthetic pathway consists of a PLP synthase which produces pyridoxal 5'-phosphate (PLP) within the parasite. The absence of this pathway in humans makes it attractive for selective targeting using small chemical molecules. The PLP synthase condenses D-ribose 5-pho

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22

NETO, Zoraima Naymbi da Silva. "Biological characterization of de-ubiquitylating enzymes (UBPs/UCHs) in Plasmodium spp as potential drug targets." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2014. http://hdl.handle.net/10362/19274.

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A malária ainda constitui um grande problema de saúde pública e a resistência aos antimaláricos ameaça todos os esforços efectuados com vista ao combate e controle desta doença. Existe uma grande necessidade de se identificar novos compostos de preferência que actuem em novos alvos terapêuticos. A via da ubiquitinação/proteosoma já foi identificada como um alvo terapêutico interessante. Mutações nas enzimas de des-ubiquitilação (DUBs) que catalizam a remoção da ubiquitina estão associadas ao desenvolvimento de doenças infecciosas e não infecciosas. Neste projecto quatro DUBs foram identificad

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Mokoena, Fortunate. "Malarial drug targets cysteine proteases as hemoglobinases." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004065.

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Malaria has consistently been rated as the worst parasitic disease in the world. This disease affects an estimated 5 billion households annually. Malaria has a high mortality rate leading to distorted socio-economic development of the world at large. The major challenge pertaining to malaria is its continuous and rapid spread together with the emergence of drug resistance in Plasmodium species (vector agent of the disease). For this reason, researchers throughout the world are following new leads for possible drug targets and therefore, investigating ways of curbing the spread of the disease.

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Hari, Har Joshi Srisin Khusmith. "Monoclonal antibody based ELISA for the detection of P. falciparum and P. vivax antigens in Malaria endemic populations in southern Nepal /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/46E-Hari-J.pdf.

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Silva, Márcia Ferreira da. "Estudos in vitro de potenciais antimaláricos nos estágios intraeritrocítico de Plasmodium falciparum." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-23042013-122652/.

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Nesta dissertação, identificou-se que as drogas esqualestatina, fosmidomicina, risedronato e nerolidol apresentam atividades sinérgicas e aditivas quando administradas em cultura de P. falciparum. Esses resultados contribuem para a compreensão da biologia do parasita e abrem estudos para possíveis antimaláricos. Identificou-se a especificidade da droga esqualestatina inibidora da enzima fitoeno sintase por meio de marcações metabólicas utilizando precursor radioativo ([3H]GGPP), e análise pela técnica de cromatografia (RP-HPLC). Realizou-se testes de inibição para determinar o valor da IC50 na

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Alberge, Blandine. "Choline et éthanolamine kinases chez Plasmodium falciparum : Caractérisation biochimique et cellulaire des enzymes et de leur activité." Montpellier 1, 2009. http://www.theses.fr/2009MON13517.

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Le développement de Plasmodium falciparum, agent du paludisme, est indissociable d’une production considérable de membranes par le parasite. Les biosynthèses de phosphatidylcholine (PC) et de phosphatidyléthanolamine (PE), principaux constituants de ces membranes, sont essentielles à la croissance du parasite au cours de son développement intraérythrocytaire, phase durant laquelle sont observés les symptômes cliniques de la maladie. Les travaux de cette thèse ont eu pour objectifs la caractérisation des premières enzymes des voies de synthèse de novo de PC et de PE chez P. Falciparum, soit res

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GALBIATI, ANDREA. "DESIGN AND SYNTHESIS OF NOVEL ENZYME INHIBITORS AS ANTIPROLIFERATIVE COMPOUNDS WITH ANTIPROTOZOAL AND ANTICANCER ACTIVITY." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/827428.

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This dissertation describes the research carried out as part of a PhD program in Chemistry from the 1st October 2017 until 30th November 2020. The PhD project investigated the development of inhibitors of enzymes involved in important metabolic pathways, with the final aim to produce an antiproliferative effect. The present thesis combines the works performed at the University of Milan and Vrije Universiteit of Amsterdam. Part A describes the research performed in Amsterdam, NL during my period abroad from January to September 2019 in the research group of Professor Rob Leurs, at the Di

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Battistini, Matthew R. "Novel Enzyme Perspectives: Arylalkylamine N-acyltransferases from Bombyx mori & 1-Deoxy- D-Xylulose-5-Phosphate Synthase from Plasmodium falciparum and Plasmodium vivax." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5908.

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This dissertation is dedicated to the research and investigation of novel enzymes and the methods used to study them, with physiological roles ranging from isoprenoid biosynthesis to neurotransmitter production. Using a combination of bioinformatics, recombinant cloning, enzymology, and proteomics, we have contributed to the understanding and exploration of several human illnesses, including malaria, cancer, and endocrine dysfunction. Our first project involved studying the enzymes responsible for N-acylarylalkylamide biosynthesis in Bombyx mori. Very little is known how these potent signaling

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ROSA, M. DE. "Characterization of ferredoxin-NADP+ reductases from pathogenic microorganisms." Doctoral thesis, Università degli Studi di Milano, 2007. http://hdl.handle.net/2434/59919.

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Ferredoxin-NADP+ reductase (FNR, EC 1.18.1.2) is a functional class of proteins that catalyzes the transfer of electron equivalents from small iron-sulphur proteins (ferredoxin, Fd) to pyridine dinucleotide, or vice versa. Two different, phylogenetically unrelated, subclasses of FNR exist: the plant-like and the mitochondrial FNRs. FprA is a mycobacterial reductase belonging to the latter class. We discovered that FprA is able to catalyse an unusual reaction, leading to the production of a modified NADP, named NADPO. I characterized its production and I showed that this reaction is a hallmark

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Jordão, Fabiana Morandi. "Caracterização da enzima bifuncional farnesil difosfato/geranilgeranil difosfato sintase e efeito do risedronato nos estágios intraeritrocitários de Plasmodium falciparum." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-23042013-093744/.

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O aumento da resistência do parasita da malária a maioria da drogas antimaláricas disponíveis, tornandose necessário pesquisar novos compostos com potencial atividade antimalárica. O objetivo desta tese foi inicialmente caracterizar a atividade do risedronato contra as formas intraeritrocitárias do parasita in vivo, além de identificar seu possível mecanismo de ação. A IC50 do risedronato foi de 20 <font face=\"Symbol\">mM em culturas de Plasmodium falciparum. Risedronato reduziu a biossíntese de FOH e GGOH e a isoprenilação de proteínas, inibindo a transferência do grupo FPP para as proteínas

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Gabriel, Heloisa Berti. "Caracterização da função biológica da vitamina K biossintetizada pelas formas intraeritrocitárias de Plasmodium falciparum." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-05082011-095206/.

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A falta de uma vacina eficaz e o problema da resistência aos fármacos têm dificultado o controle da malária. A busca de novos alvos biológicos para o desenvolvimento de antimaláricos eficazes tem se concentrado, em parte, na pesquisa e compreensão de vias metabólicas exclusivas do parasita. Nosso grupo vem investigando e caracterizando produtos da biossíntese de isoprenóides em P. falciparum. Resultados preliminares identificaram a biossíntese das duas formas da vitamina K: filoquinona (PhQ) e menaquinona (MQ), ambas provenientes das vias do chiquimato e da via 2-C-metil-D-eritritol-4-fosfato

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Häußler, Kristina Maria Elisabeth [Verfasser]. "Characterization and inhibition of NADPH-producing enzymes from the pentose phosphate pathway of Plasmodium parasites / Kristina Maria Elisabeth Häußler." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1175873500/34.

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Häußler, Kristina [Verfasser]. "Characterization and inhibition of NADPH-producing enzymes from the pentose phosphate pathway of Plasmodium parasites / Kristina Maria Elisabeth Häußler." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1175873500/34.

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Nascimento, Marília Nunes do. "Desenvolvimento de modelos de QSAR e planejamento de novos inibidores da enzima dUTPase de Plasmodium falciparum." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5105.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-01-14T08:51:05Z No. of bitstreams: 2 Dissertação - Maríilia Nunes do Nascimento - 2015.pdf: 2988580 bytes, checksum: 941d336cea1a51aeb45d97702067875a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-01-15T08:54:06Z (GMT) No. of bitstreams: 2 Dissertação - Maríilia Nunes do Nascimento - 2015.pdf: 2988580 bytes, checksum: 941d336cea1a51aeb45d97702067875a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b8

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Garcia, Mariana Lopes. "Estudos computacionais da enzima N-miristoiltransferase de Plasmodium falciparum e seus inibidores como candidatos a agentes antimaláricos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-15092017-084415/.

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A malária é uma doença infecciosa causada pelos parasitas do gênero Plasmodium e transmitida pelo mosquito Anopheles spp. Devido ao surgimento de casos de resistência aos fármacos disponíveis novos alvos e candidatos a fármacos são necessários. Recentemente, a enzima N-miristoiltransferase (NMT) foi confirmada como essencial para o parasita e validada como alvo terapêutico para o desenvolvimento de candidatos a fármacos antimaláricos. O objetivo desse trabalho foi identificar os determinantes moleculares responsáveis pela atividade inibitória de uma série de derivados benzotiofênicos frente à

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Maluf, Fernando Vasconcelos. "Estudos estruturais e de química medicinal aplicados às enzimas da via glicolítica de protozoários: enolase de Plasmodium falciparum e gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-02102015-093453/.

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A melhor compreensão dos mecanismos fisiopatológicos e farmacológicos aliados a métodos modernos de investigação tornaram possível a descoberta e o desenvolvimento de fármacos para diversas doenças e disfunções orgânicas em humanos. Os fármacos desenvolvidos atualmente são resultados de intensos esforços em pesquisa por equipes multidisciplinares, impactando diretamente na qualidade de vida das diversas populações no mundo. Nesse cenário, os grupos de pesquisas estabelecidos em Universidades com foco no planejamento de fármacos para doenças tropicais têm crescido. A Malária e a Doença de Chaga

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Macedo, Karlla Gonçalves de. "Estudos de SAR e QSAR para um conjunto de triazolopirimidinas inibidores da enzima diidroorotato desidrogenase de Plasmodium falciparum." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4755.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-10-23T17:15:13Z No. of bitstreams: 2 Dissertação - Karlla Gonçalves Macedo - 2014.pdf: 3559333 bytes, checksum: be77b4325f787c0048a0c9a15e8c800b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-10-23T17:16:49Z (GMT) No. of bitstreams: 2 Dissertação - Karlla Gonçalves Macedo - 2014.pdf: 3559333 bytes, checksum: be77b4325f787c0048a0c9a15e8c800b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306

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Moyo, Sipho Dugunye. "Comparative study of clan CA cysteine proteases: an insight into the protozoan parasites." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1020309.

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Protozoan infections such as Malaria, Leishmaniasis, Toxoplasmosis, Chaga’s disease and African trypanosomiasis caused by the Plasmodium, Leishmania, Toxoplasma and Trypanosoma genuses respectively; inflict a huge economic, health and social impact in endemic regions particularly tropical and sub-tropical regions. The combined infections are estimated at over a billion annually and approximately 1.1 million deaths annually. The global burden of the protozoan infections is worsened by the increased drug resistance, toxicity and the relatively high cost of treatment and prophylaxis. Therefore th

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Leoratti, Fabiana Maria de Souza. ""Resposta imune humoral na malária humana: quantidade e qualidade de anticorpos anti-Plasmodium falciparum"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-04102005-144150/.

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Neste estudo avaliamos a resposta imune humoral de indivíduos naturalmente expostos à malária em áreas endêmicas no Brasil. Os anticorpos IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgE e IgA anti-formas eritrocitárias de Plasmodium falciparum foram determinadas por ELISA. Anticorpos IgG, IgG1, IgG2 de alta avidez e IgG3 de baixa avidez predominaram nos indivíduos sem complicações de malária ou assintomáticos, enquanto anticorpos IgG4, IgE e IgM predominaram nos indivíduos com complicações clínicas por malária. Os resultados mostram que mesmo em regiões com transmissão instável de malária pode ser obser

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Grava, Andréa Fagundes. "Utilização da enzima β-cetoacil ACP redutase (OAR) da via FAS II de Plasmodium falciparum como um alvo para busca de novos compostos antimaláricos". Universidade Federal do Amazonas, 2014. http://tede.ufam.edu.br/handle/tede/5657.

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Submitted by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-04-24T13:03:47Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese - Andréa F. Grava.pdf: 2269814 bytes, checksum: 93a2229b90f5c8d077e8753c3fe82db6 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-04-24T13:04:05Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese - Andréa F. Grava.pdf: 2269814 bytes, checksum: 93a2229b90f5c8d077e8753c3fe82db6 (MD

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VALLONE, ALESSANDRA. "INVESTIGATION OF NOVEL THERAPEUTIC TOOLS AGAINST INFECTIOUS DISEASES Part 1. Medicinal Chemistry Investigation of MMV019918 Derivatives as Dual Schizonticide And Gametocytocidal Agents Against Plasmodium falciparum Part 2. Investigation of 5-Aryl-Heterocycles As Potential Inhibitors of Metallo beta-Lactamase Enzymes." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1004943.

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Among infectious diseases, two large groups have great clinical relevance: parasitic and bacterial infections. Belonging to the first category is malaria, caused by the parasite Plasmodium falciparum. Transmission of Plasmodium parasites between humans and Anopheles mosquitoes is one of the most important contributors to the global impact of malaria and to the difficulties encountered in eliminating this parasite1 . Gametocytogenesis, the process by which merozoites switch from asexual replication to produce male and female gametocytes, represents a critical step in malaria transmission

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Tello, Sánchez Maribel Liliana. "Eficacia del ensayo inmuno-enzimático de detección de la enzima lactato deshidrogenasa (Deli) y ensayo de fluorescencia para malaria basado en el reactivo SYBR green-I (MSF) para calcular la IC50 de drogas anti-Plasmodium falciparum. Iquitos 2015." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/10853.

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Determina la eficacia de las pruebas DELI y MSF para calcular la IC50 de drogas antimaláricas mefloquina, quinina y cloroquina obtenidas de aislamientos de P. falciparum provenientes de pobladores de la comunidad de Padre Cocha en Iquitos-Perú. Se realizó un estudio cuantitativo descriptivo, prospectivo de corte transversal. La muestra fueron 16 muestras de sangre con diagnóstico de malaria confirmado por gota gruesa. Se realizaron los dos ensayos de sensibilidad in vitro (DELI y MSF) a cada muestra. Se determinaron tres factores de eficacia para el presente estudio; porcentaje de éxito, coefi

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Banerjee, Mousumi. "Structure-Function Studies On Triosephoshate Isomerase From Plasmodium falciparum And Methanocaldococcus jannaschii." Thesis, 2008. http://hdl.handle.net/2005/824.

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This thesis describes studies directed towards understanding structure-function relationships of triosephosphate isomerase (TIM), from a protozoan parasite Plasmodium falciparum and a thermophilic archaea Methanocaldococcus jannaschii. Triosephosphate isomerase, a ubiquitous glycolytic enzyme, has been the subject of biochemical, enzymatic and structural studies for the last five decades. Studies on TIM have been central to the development of mechanistic enzymology. The present study investigates the role of specific residues in the structure and function of Plasmodium falciparum triosephospha

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Marreiros, Maria Inês Moreira Oliveira Leite. "Characterization of Plasmodium methionine metabolism key enzyme." Master's thesis, 2016. http://hdl.handle.net/10451/25946.

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Tese de mestrado, Biologia Molecular e Genética, Universidade de Lisboa, Faculdade de Ciências, 2016<br>Malaria is a disease caused by protozoan parasites of the genus Plasmodium that are transmitted to humans by infected female Anopheles mosquitoes. Despite countless efforts toward eradication malaria still remains one of the most prevalent infectious diseases, constituting a major public health concern. The available antimalarial drugs are insufficient to control and eradicate malaria, mostly due to the emergence of drug-resistant parasites. Thus, the development of novel intervention strate

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Maity, Koustav. "Structure Analysis Of FabI And FabZ Enzymes Of The Fatty Acid Biosynthesis Pathway Of Plasmodium Falciparum." Thesis, 2010. http://hdl.handle.net/2005/2221.

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The emergence of drug resistant strains of Plasmodium has given a new face to the old disease, malaria. One of the approaches is to block metabolic pathways of the pathogen. The current thesis describes the X-ray crystallographic analysis of two enzymes of the fatty acid biosynthesis pathway of the malaria parasite Plasmodium falciparum. In order to understand the functional mechanism and mode of inhibitor binding, enzyme-inhibitor complexes were characterized, which could help in further improvement of the efficacy of the inhibitors and hence to fight against the disease. The introductory c

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Pidugu, Lakshmi Swarna Mukhi. "Structural Studies On The Enzymes FabI And FabZ Of Plasmodium Falciparum." Thesis, 2006. http://hdl.handle.net/2005/381.

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The thesis deals with X-ray crystallographic analysis of two enzymes involved in the fatty acid biosynthesis pathway, known as Fatty Acid Synthase or FAS, of the malarial parasite, Plasmodium falciparum, in order to understand their functions at the atomic level and to provide structural basis for the rational design of antimalarial compounds. Targeting highly specific and well-characterized biochemical pathways to develop effective therapeutic agents has the advantage of designing new drugs or modifying the existing ones based on the details of the known features of the processes. Knowledge o

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Krause, Robert Gerd Erich. "The detection of two plasmodium falciparum metabolic enzymes using chicken antibodies." Thesis, 2012. http://hdl.handle.net/10413/8522.

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Three protein targets are used in malaria rapid diagnostic tests (RDTs). These are Plasmodium falciparum histidine rich protein 2, Plasmodium lactate dehydrogenase and aldolase. A thrust of research in RDTs is to improve on their specificity and sensitivity. In this study the current diagnostic target, P. falciparum lactate dehydrogenase (PƒLDH) was compared to a new target glyceraldehyde-3-phosphate dehydrogenase (PƒGAPDH) that was identified based on transcriptional data. These proteins are conserved amongst all Plasmodium species, with minor amino acid sequence variations which were evaluat

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Mtombeni, Nokuhle. "The characterization of the phosphatidyl-inositol-3-kinase in plasmodium falciparum and the effect of selective inhibitors of this enzyme on the parasite." Thesis, 2004. https://hdl.handle.net/10539/25720.

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Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2004<br>Malaria is the most prevalent parasitic disease in the world and the emergence of drug resistant strains of Plasmodium falciparum has made the search for new antimalarial drugs important. Protein kinases play an important role in cellular function and the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway is implicated in diverse cellular processes such as glucose transpor

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Krüger, Tim [Verfasser]. "Charakterisierung von Phosphatidylinositol-metabolisierenden Enzymen in Plasmodium falciparum / vorgelegt von Tim Krüger." 2008. http://d-nb.info/989544087/34.

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Yang, Hao. "Role of host haem biosynthetic enzymes in the Plasmodium falciparum erythrocyte-stage." Phd thesis, 2019. http://hdl.handle.net/1885/157107.

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Plasmodium falciparum is a parasite that causes severe type of malaria, including cerebral malaria. Its growth and survival in erythrocytes relies on haem, an essential metabolic cofactor participating in various redox reactions of nearly all eukaryotic organisms. Research has therefore focused on interfering with the acquisition of haem by studying three ways parasite can access haem. The first way is through its own de novo haem synthetic pathway (HSP), in which succinyl-CoA and glycine are converted into haem through a series of eight enzymatic steps. The second and third ways are to scaven

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