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Rozprawy doktorskie na temat „Platelet response”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Murphy, Christine Therese. "Mechanisms of stimulus-response coupling in platelet-activating factor stimulated platelets." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304999.

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Rattray, Andrew. "Platelet response to haemodynamic shear forces." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367819.

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Muller, Michael John. "Modulation of the response to cutaneous injury /." [St. Lucia, Qld.], 2000. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16146.pdf.

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Navaratnam, K. "Platelet function and response to low-dose aspirin in pregnancy." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009774/.

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Pre-eclampsia is a serious multisystem disorder unique to pregnant women and associated with significant maternal and perinatal morbidity and mortality worldwide. Despite the investment of decades of basic science and clinical research, the pathophysiology of pre-eclampsia has been incompletely illustrated. In low doses, the cyclooxygenase inhibitor and antiplatelet, aspirin, can redress the thromboxane/prostacyclin imbalance observed in pregnancies affected by pre-eclampsia. Low-dose aspirin is currently recommended for high risk pregnancies in many countries, despite affording only modest ov

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Allen, David L. "A study of the Human Platelet Antigen 1a (HPA-1a) antibody response in neonatal alloimmune thrombocytopenia (NAIT)." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:44a10539-de5d-44dc-9c51-5f43cf3c3a82.

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Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal alloantibodies against fetal platelet antigens inherited from the father and which are absent from maternal platelets. In Caucasians, antibodies against the Leu33 (HPA-1a) polymorphism of integrin β3 (part of the platelet αIIbβ3 complex) account for >70% of cases. Antenatal screening for these antibodies does not currently take place in the UK, partly because of the absence of sensitive, predictive tests. We hypothesized that the poor sensitivity and predictive abilities of current assays are due to the use of β3 in an inappropr

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Järemo, Petter. "Platelets and the inflammatory response in coronary heart disease /." Linköping, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med816s.pdf.

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Barbosa, Alzira Maria de Castro. "Chronic immune thrombocytopenic purpura and infection Helicobacter pylori: platelet response to the bacteria elimination of treatment." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16378.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The Chronic Immune Thrombocytopenic Purpura (ITPc) is a condition caused by autoimmune response resulting awareness of platelets by self antiplatelet antibodies, causing lysis of platelets. Infection with H. pylori has been shown to likely factor for the development of PTIc, with possible platelet response relationship in PTIc after treatment of bacterial eradication. The objective was to evaluate possible effects of eradication of Helicobacter pylori in the number of platelets of patients with PTIC patients at the University Hos

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8

Narayanan, Padmini. "Interleukin 1 Receptor1 signaling in Platelet Inflammatory responses Interleukin-1ß processing and secretion." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1425911007.

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Nijm, Johnny. "Inflammation and cortisol response in coronary artery disease /." Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1037s.pdf.

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10

Balasubramaniam, Karthik. "Platelet dependent thrombosis, blood thrombogenicity and response to antiplatelet therapy in health, ageing and type 2 diabetes mellitus." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3499.

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Elderly and type 2 diabetes mellitus (T2DM) patients with stable coronary artery disease (CAD) have increased risk of atherothrombotic events despite recommended secondary prevention therapy. High platelet reactivity drives this risk. Novel approaches to antiplatelet therapy are needed. Objectives: To:  determine the effect of age and T2DM on blood thrombogenicity and response to dual antiplatelet therapy in stable CAD  assess the effect of changes in platelet count on thrombus quantity and quality with Rafigrelide Methods: Study 1: Patients with stable CAD, 4 groups: age < 75 non-DM, age≥75

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11

Wong, Shen. "The measurement of platelet function in response to 3 common antiplatelet regimens in patients with peripheral occlusive arterial disease." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27942.

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Background: Anti-platelet therapy reduces vascular complications in patients with peripheral occlusive arterial disease (POAD) with aspirin the most commonly prescribed agent. However, aspirin resistance can be observed in patients who suffer clinical thromboembolic events, or have persistent platelet activity despite regular aspirin treatment. The clinical benefits of clopidogrel or combination aspirin and clopidogrel therapy may be due to superior platelet inhibition or the inhibition of platelets in aspirin resistant patients. Aim: To investigate the effects of aspirin, clopidogrel

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12

Gandhi, Neha Sureshchandra. "Molecular modelling of platelet endothelial cell adhesion molecule 1 and its interaction with glycosaminoglycans." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/1513.

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The Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) has many functions including its roles in leukocyte extravasation as part of the inflammatory response, and in the maintenance of vascular integrity through its contribution to endothelial cell-cell adhesion. Various heterophilic ligands of PECAM-1 have been proposed. The possible interaction of PECAM-1 with glycosaminoglycans (GAGs) is the focus of this thesis. The three dimensional structure of the extracellular immunoglobulin (Ig)-domains of PECAM-1 was constructed using homology modelling and threading methods. Potential heparin/h

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13

Varenhorst, Christoph. "Platelet Inhibition in Coronary Artery Disease – Mechanisms and Clinical Importance : Studies with Focus on P2Y12 Inhibition." Doctoral thesis, Uppsala universitet, Medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131154.

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Despite the currently recommended dual antiplatelet treatment (DAT) with aspirin and P2Y12 inhibition in patients with coronary artery disease (CAD) there is a risk of adverse clinical outcome. Pharmacodynamic (PD) poor response to clopidogrel occurs in ~ 30% of clopidogrel-treated patients and is associated with an increased risk of recurrent thrombotic events. The aims of this thesis were to compare the PD and pharmacokinetic effects of clopidogrel 600 mg loading dose (LD)/ 75 mg standard maintenance dose (MD) with the novel P2Y12 inhibitor prasugrel 60 mg LD/10 mg MD, in 110 patients with C

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14

Smith, Simon Matthew Giles. "Investigations into the genetic basis of platelet responsiveness to adenosine diphosphate and thrombin receptor activating peptide, and the variable response to clopidogrel therapy." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444830.

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15

Christian, Lea Rajeshkumar. "Xeroderma Pigmentosum A Deficiency Results in Increased Generation of Microvesicle Particles in Response to Ultraviolet B Radiation." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1621875551264658.

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Kroegel, Claus. "Molecular mechanisms of stimulus-response coupling in human and guinea pig eosinophils : transduction pathways utilized by platelet activating factor and their relationship to cellular effector functions." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46876.

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17

Buitrago, Murcia Claudia Lorena. "Cbl proteins in platelet functional responses." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/198139.

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Physiology<br>Ph.D.<br>c-Cbl protein functions as an E3 ligase and scaffolding protein, where three residues, Y700, Y731, and Y774, upon phosphorylation, have been shown to initiate several signaling cascades. In this study, we investigated the role of these phospho-tyrosine residues in the platelet functional responses upon integrin engagement. We observed that c-Cbl Y700, Y731 and Y774 undergo phosphorylation upon platelet adhesion to immobilized fibrinogen, which was inhibited in the presence of PP2, a pan-src family kinase (SFK) inhibitor, suggesting that c-Cbl is phosphorylated downstream

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18

Shaw, A. M. "Cytosolic free calcium and platelet responses to putative lipid mediators of platelet activation." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378176.

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19

Sage, Stewart O. "Stimulus-response coupling in human blood platelets." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236016.

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Bosnic, Anthony Martin. "Human antibody responses to a chlamydia-secreted protease factor : a thesis /." San Antonio : UTHSC, 2005. http://learningobjects.library.uthscsa.edu/cdm4/item%5Fviewer.php?CISOROOT=/theses&CISOPTR=14&REC=5.

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21

Cardoso, Andréia Machado. "Efeitos do exercício físico sobre a atividade de enzimas dos sistemas purinérgico e colinérgico em sangue de ratos hipertensos." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/4482.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Hypertension is a multifactor clinical condition, which is accompanied by a low-grade inflammation and alterations in platelet function. These modifications may be related to an imbalance in the regulation of adenine nucleotides (ATP, ADP and AMP), adenosine and acetylcholine (ACh) levels. This regulation is performed by purinergic [NTPDases, ecto-5 - nucleotidase and adenosine deaminase (ADA)] and cholinergic [Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE)] system enzymes, present in blood, respectively. These

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22

Bhavanasi, Dheeraj. "Role of Protein Kinase C delta in regulating platelet functional responses." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/283099.

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Physiology<br>Ph.D.<br>Platelets upon activation change their shape, aggregate and secrete alpha and dense granule contents among which ADP acts as a feedback activator. Different Protein Kinase C (PKCδ) isoforms have specific non-redundant roles in mediating platelet responses including secretion and thrombus formation. Protein Kinase C delta (PKCδ), a novel class of PKC isoform requiring diacyl glycerol but not calcium for its activation, has been shown to play an important role in several pathological processes. The aims of our current study are 1) to identify possible PKCδ specific substra

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23

Albrecht, Madlin [Verfasser], and Ingo [Akademischer Betreuer] Ahrens. "The role of platelet immuno-receptors in patients with acute coronary syndrome and C-reactive protein induced pro-inflammatory gene response in early endothelial progenitor cells = Die Rolle von Plättchen Immuno-Rezeptoren bei Patienten mit akutem Koronarsyndrom und Einfluss von C-reaktivem Protein auf endotheliale Progenitorzellen." Freiburg : Universität, 2014. http://d-nb.info/1123481938/34.

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24

Scase, Timothy John. "Blood platelet responses induced by adenosine 5'-diphosphate : functional and molecular studies." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624899.

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Poole, Alastair W. "Responses of equine blood platelets induced by adenosine 5'-diphosphate." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260575.

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26

Wright, Joy Rhiannon. "Variation in the haemostatic response and thrombotic risk : interplay between haemostatic factors, platelets and monocytes." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/10075.

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The haemostatic response comprises the interaction of coagulation factors and peripheral blood cells which play a vital role in maintaining vascular integrity. This study begins with the finding that plasma from premature MI subjects has increased endogenous thrombotic potential linked to higher levels of circulating Tissue Factor (TF), suggesting these individuals may have a hypercoagulable phenotype. This study seeks to further understand how cellular interaction, in particular platelet-monocyte interaction, modulates the haemostatic response. Throughout the study, TF and Tissue Factor Pathw

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Plant, Stuart D. "The response of human umbilical vein endothelial cells and blood platelets to modified NiTi surfaces." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275630.

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28

Salehe, Bajuna Rashid. "Predictive tools for the study of variations in ADP platelet responses : implications for personalised CVD risk and prevention strategies." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/74255/.

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The major aim of this project is to develop novel computational approaches for rapid identification of key omic variations, particularly SNPs that are likely to be associated with the variability of the ADP (Adenosine diphosphate) activated platelet responses. The ADP platelet response was chosen as a model system due to its distinct role during the platelet amplification and aggregation, and it is the main therapeutic target for cardiovascular disease (CVD) antiplatelet drug treatments. Based on recent studies, CVD is currently the second lethal noncommunicable disease after cancer in both de

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29

Field, Cara Lisa. "A biophysical characterization of northern elephant seal (Mirounga angustirostris) blood platelets and response to temperature and pressure changes /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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Ferraz, Natalia. "Effect of Surface Nanotopography on Blood-Biomaterial Interactions." Doctoral thesis, Uppsala universitet, Institutionen för fysikalisk och analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110614.

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Biologically inspired materials are being developed with the aim of improving the integration of medical implants and minimizing non-desirable host reactions. A promising strategy is the design of topographically patterned surfaces that resemble those found in the extracellular environment. Nanoporous alumina has been recognized as a potential biomaterial and as an important template for the fabrication of nanostructures. In this thesis in vitro studies were done to elucidate the role of alumina nanoporosity on the inflammatory response. Specifically, by comparing alumina membranes with two po

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Larsson, Jimmy. "Neural stem and progenitor cells cellular responses to known and novel factors /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110722.

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Nosul, Matylda [Verfasser], and Gerald [Akademischer Betreuer] Kolb. "Erfassung von Acetylsalicylsäure Non-Responder mittels Platelet Function Analyser (PFA-100) und Risikofaktoren nach ischämischem Insult bei geriatrischen Patienten / Matylda Nosul. Betreuer: Gerald Kolb." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1038786576/34.

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Imperiali, Rosario Claudia. "Evaluación de la fracción de plaquetas inmaduras y de otros biomarcadores asociados a complicaciones inflamatorias en el postoperatorio de cirugía cardíaca." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671171.

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Gràcies als avenços en la disciplina i a causa del canvi en l’estil de vida de la població, el nombre de cirurgies cardíaques s’ha vist incrementat amb el temps. Donades les característiques de la cirurgia i dels pacients que es sotmeten a elles; cada vegada més longeus i amb un major nombre de comorbiditats, existeix un important risc d’aparició de complicacions postoperatòries que poden arribar a comprometre l’èxit de la intervenció. La complexitat de la cirurgia i dels procediments dels quals d’ella deriven, donen lloc a una resposta inflamatòria reactiva que, en certs casos, pot veure’s

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Huber-Petersen, Lisa. "Häufigkeit und Auswirkungen der ASS Non-Response bei kardiochirurgischen Patienten." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E313-1.

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Ross, Julia Myers. "Platelet interactions with subendothelial surfaces under physiological shear conditions: Response to type VI collagen and an endothelial cell wound model." Thesis, 1995. http://hdl.handle.net/1911/16874.

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The elucidation of the molecular mechanisms of platelet adhesion and aggregation in response to naturally occurring subendothelial surfaces under flow conditions is important medically in atherosclerosis and mural thrombosis. Type VI collagen is a subendothelial constituent that binds vWF and platelets. The interaction of platelets with type VI collagen and the roles of platelet glycoprotein receptors and vWF were studied under flow conditions using epi-fluorescent video microscopy coupled with digital image processing. We found that surface coverage was less than 6% on collagen VI at a high w

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Lin, Yu-An, and 林祐安. "Immune and Osteogenic Response to Zirconia Surface Immobilized with Bone Morphogenetic Protein-2 and Platelet-rich Plasma Released Cytokines through a Natural Cross-linker." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ap6vcj.

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Lauener, Ronald William. "Role of phosphoinositide 3-kinase in platelet responses to platelet-activating factor." Thesis, 1997. http://hdl.handle.net/2429/6652.

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Platelets are necessary for hemostasis but are also involved in a broad range of pathophysiologic processes such as atherosclerosis and thrombosis. Platelet activating factor (PAF), an inflammatory mediator, is an important physiological regulator of platelet function. The major objective of this work was to determine the role of phosphoinositide 3-kinase (PI 3-kinase) in platelet responses to platelet activating factor. We show, for the first time in platelets, that PAF activates PI 3-kinase over a rapid time course that correlates closely with the aggregation response. The potent PI 3-

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Lordkipanidzé, Marie. "Étude de l’effet des médicaments antiplaquettaires sur la fonction plaquettaire : de la variabilité de réponse à l’effet rebond." Thèse, 2009. http://hdl.handle.net/1866/3953.

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En inhibant la formation de caillots dans le sang, les médicaments antiplaquettaires diminuent de façon importante le risque d’événements ischémiques aigus. Cependant, une sous-population de patients souffrant de maladie coronarienne présente une inhibition inadéquate de la fonction plaquettaire malgré la prise quotidienne d’acide acétylsalicylique (AAS). Le premier volet de cette thèse démontre qu’une régénération plaquettaire accélérée pourrait expliquer en partie la variabilité dans la persistance de l’effet antiplaquettaire de l’AAS chez certains sujets souffrant de maladie coronarienne.

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Konstantopoulos, Konstantinos. "Flow cytometric studies of platelet responses to shear stress." Thesis, 1995. http://hdl.handle.net/1911/16842.

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The objective of this study was to improve our understanding of platelet involvement in vascular disease. A cone-and-plate viscometer was used to simulate the fluid mechanical conditions in narrowed arteries. Platelet responses induced by shear stress were quantitated by flow cytometry. This methodology allows the study of platelets in whole blood rather than in platelet suspensions in buffer or plasma, a situation that reflects more closely the physiologic status of platelets circulating in vivo. Using this technique, platelets and platelet aggregates were distinguished from the other blood c

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Cheng, Hui-ju, and 鄭慧茹. "The mechanism underlying the response of platelets to Streptococcus pyogenes bacteria." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/76628057505852548259.

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碩士<br>慈濟大學<br>藥理暨毒理學研究所<br>94<br>Circulating platelets play an important role in the pathogenesis of infectious endocarditis, a severe disease caused mostly by the infection of Gram-positive bacteria. Platelets may help bacteria attach to endocardium, initiating endocarial infection, followed by facilitating the formation of macroscopic vegetation which may disperse away from valves, resulting in systemic embolization. Given the interaction of bacteria with platelets is a critical virulent mechanism for bacteria to induce infectious endocarditis, a better understanding of the processes involv

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Worthley, Matthew I. "Tissue responses to nitric oxide donors: studies in platelets and in myocardium." Thesis, 2004. http://hdl.handle.net/2440/37979.

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The nitric oxide molecule (NO ·) is without doubt one of the most influential on the pathophysiology of the cardiovascular system. Its effects are broad ranging in this system influencing almost all of its components, particularly the vasculature, platelets and the myocardium. The beneficial effects of this molecule not only in inhibiting the development of cardiovascular disease (CVD) but in minimizing the risk of its acute thrombotic complications makes it an obvious target for therapies designed to enhance its effects. Assessing the tissue effects of NO · in platelets and the myocardium has

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Worthley, Matthew I. "Tissue responses to nitric oxide donors: studies in platelets and in myocardium." 2004. http://hdl.handle.net/2440/37979.

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The nitric oxide molecule (NO ·) is without doubt one of the most influential on the pathophysiology of the cardiovascular system. Its effects are broad ranging in this system influencing almost all of its components, particularly the vasculature, platelets and the myocardium. The beneficial effects of this molecule not only in inhibiting the development of cardiovascular disease (CVD) but in minimizing the risk of its acute thrombotic complications makes it an obvious target for therapies designed to enhance its effects. Assessing the tissue effects of NO · in platelets and the myocardium has

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McCrary, Jeffrey Kirk. "Receptor-specific binding of von Willebrand factor to platelets in response to shear stress." Thesis, 1994. http://hdl.handle.net/1911/16757.

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Physical and biochemical forces convert platelets in human blood in vivo from the quiescent state as freely moving, discoid, singlets to aggregates adhering to subendothelial surfaces and secreting a wide variety of bioactive substances. Platelet aggregation, one of the essential components of hemostasis, can be caused in vitro by several chemical agonists, and by shear stress, as is found in flowing blood. Platelet aggregation at high shear stress is a receptor-mediated process requiring the binding of the plasma protein von Willebrand factor (vWf) to platelets. This study was undertaken to d

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Plein, Helene. "The platelet as a peripheral marker of the (receptor regulated calcium) second messenger responses in psychiatric illness." Thesis, 2014.

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This thesis examines the use of the platelet as a peripheral marker of receptor regulated calcium second messenger responses of neuronal cells in major depression, subsyndromal depression, panic disorder and schizophrenia. These psychiatric disorders have substantia] overlap in clinical symptomatology. Identification of a peripheral marker that might differentiate the disease conditions in terms of the underlying pathophysiology of the illness would greatly benefit the diagnosis and treatment o f the psychiatric illnesses.Platelet intracellular calcium in response to neurotransmitter stimulat

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Sterling, Katherine. "The role of CD8+ T cells in the regulation of recipient immune responses induced by allogeneic platelet transfusions." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=81000&T=F.

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Simpson, Elisa. "Mechanisms of Action and Relative Efficacy of Glucocorticosteroid Treatment in Ameliorating Immune Thrombocytopenia Induced by Anti-platelet GPIbα Versus GPIIbIIIa Immune Responses". Thesis, 2012. http://hdl.handle.net/1807/42899.

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Immune thrombocytopenia (ITP) is an autoimmune disorder, mediated mainly by autoantibodies against platelet glycoprotein GPIIbIIIa and GPIbα resulting in enhanced platelet destruction. Decreased platelet production and cellular immunity also contribute to ITP. GPIIbIIIa and GPIbα are distinct platelet receptors. Previous studies suggested that anti-GPIbα (versus anti-GPIIbIIIa)-mediated ITP is less responsive to IVIG therapy. However, little information is available whether antibody specificities also dictate efficacy of Glucocorticosteroids (GC), which are the first-line ITP treatment. Here,

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Su, Chen-Yi, and 蘇珍儀. "The effects of ganodermic acid S on the responses of human platelets to the thromboxane A2 analogue U46619, collagen and prostaglandin E1." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/81462574792308182493.

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博士<br>國立清華大學<br>生命科學系<br>87<br>Ganodermic acid S (GAS) [lanosta-7,9(11),24-triene-3beta,15alpha-diacetoxy-26-oic acid], a triterpene isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae), exerts multiple effects on human platelet responses to various aggregating agonists. The thesis investigated how GAS less than 16 microM may affect the responses of human gel-filtered platelets (GFP) to (1) thromboxane (TX) A2 mimetic U46619, (2) collagen, and (3) prostaglandin (PG) E1. In platelet response to U46619, GAS inhibited Ca2+ mobilization, phosphorylatio

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