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Rozprawy doktorskie na temat „Platelet Rich Fibrin (PRF)”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Dohan, David. "Platelet Rich Fibrin (PRF) : modèle théorique et études préliminaires." Paris 5, 2005. http://www.theses.fr/2005PA05M004.

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Le PRF (Platelet Rich Fibrin) est un adjuvant chirurgical issu des technologies des colles de fibrine et des concentrés plaquettaires autologues de première génération (les PRP). L'objectif de ce travail est de réaliser une synthèse historique et technologique de cette famille d'adjuvants chirurgicaux à base de fibrine, de tenter de déterminer un premier modèle théorique de l'architecture moléculaire du PRF et enfin, à l'aide d'observations cliniques et d'analyses histologiques, d'évaluer le potentiel cicatriciel du PRF au niveau des tissus mous ainsi qu'au cours de la maturation des greffes o

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Peck, M. Thabit. "The effect of storage time on the platelet concentration of Choukroun's platelet rich fibrin (PRF)." University of the Western Cape, 2011. http://hdl.handle.net/11394/5219.

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Magister Chirurgiae Dentium (MChD)<br>Wound healing is a complex process characterised by the repair and reconstitution of lost or damaged tissue. By the mid 1990s, several methods were proposed to enhance wound healing of surgical sites by introducing high concentrations of human platelets to these areas. In the early 21st century, Choukroun et al (2006b) introduced a new type of platelet concentrate that was devoid of any additives, and required no specialised equipment for its production. This concentrate was termed Platelet-rich fibrin (PRF) and although various aspects of this biomaterial

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MURGIA, Denise. "NEW GUIDED BONE REGENERATION PROCEDURE USING LEUKOCYTE AND PLATELET RICH FIBRIN (L PRF) IN ORAL SURGERY." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/500658.

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Non-transfusional hemocomponents are autogenous products used in several surgical fields obtained by the centrifugation of a blood sample from a patient and able to promote hard and soft tissue regeneration, local haemostasis, and the acceleration of wound healing. The aim of this PhD thesis was the validation of an innovative protocol for the Guided Bone Regeneration (GBR) technique using second-generation autologous platelet concentrates, Leukocytes and Platelet-rich Fibrin (L-PRF), in post-extraction sockets of patients in need of dental avulsions and successive implant prosthetic rehabili

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Zhu, Christina Zhen Chao. "The effect of leucocyte and platelet-rich fibrin (L-PRF) on healing of bone defects in dogs." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18851.

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Objective: To evaluate and compare healing between L-PRF, cancellous bone graft(BG) and L-PRF and BG(BOTH) on the gap created during tibial tuberosity advancement procedure(TTA). Study Design: Prospective clinical study involving dogs treated with TTA (n=36). Hypothesis: The first hypothesis was that L-PRF could be used in dog long bones without causing clinically evident complications. The second hypothesis was that bone defects filled with BOTH would heal faster than those filled with BG alone. Material and Methods: Dogs underwent TTA at the University Veterinary Teaching Hospital Sydney vi

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Bhamjee, Feheem. "The in vitro antimicrobial activity of advanced platelet rich fibrin (A-PRF) against microorganisms of the oral cavity." University of the Western Cape, 2017. http://hdl.handle.net/11394/6232.

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Magister Chirurgiae Dentium - MChD (Oral Medicine and Periodontics)<br>In recent years, the development and use of autologous platelet rich concentrates (PC's) has gained traction within the rapidly progressive, multidisciplinary field of regenerative medicine. A PC subtype, marketed as advanced platelet rich fibrin (A- PRF), is a recent advancement of the original PRF protocol and promoted as a "blood concentrate" containing platelets, leukocytes, circulating stem cells and endothelial cells. A-PRF in the form of membranes, plugs, or even shredded particulates are increasingly being used as s

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Malzoni, Carolina Mendonça de Almeida. "Utilização da fibrina rica em plaquetas e leucócitos (L-PRF) em procedimentos cirúrgicos de elevação do assoalho do seio maxilar /." Araraquara, 2020. http://hdl.handle.net/11449/192532.

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Orientador: Daniela Leal Zandim-Barcelos<br>Resumo: A fibrina rica em plaquetas e leucócitos (L-PRF) é um derivado plaquetário autógeno capaz de liberar citocinas e fatores de crescimento favoráveis ao reparo tecidual. Por esta razão a L-PRF vem sendo utilizada em diversos procedimentos odontológicos. Uma das aplicabilidades clínicas da L-PRF é em procedimentos de levantamento do seio maxilar, uma técnica já consagrada na odontologia que permite a colocação de implantes dentários em região posterior de maxilas atróficas. Para avaliar a efetividade do uso da L-PRF, dois estudos clínicos indepen

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McCormack, Danielle M. "Profiling Precursor Lipids for Specialized Pro-Resolution Molecules in Platelet-Rich Fibrin Following Fish Oil and Aspirin Intake." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4761.

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Background: Current research has demonstrated that aspirin and fish oil (EFA) increase plasma levels of specialized pro-resolution molecules (SPMs). This study investigates their effects on SPM precursor pools in platelet rich fibrin (PRF). Methods: Twenty healthy volunteers were randomly assigned to take aspirin; EFA or aspirin and EFA. Four hours later, SPM precursor levels were quantified using combined Liquid Chromatography tandem mass spectrometry. The differences between the groups: Aspirin (yes or no), EFA (yes or no), were analyzed by ANCOVA, testing for group differences after covaryi

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Hasan, Fadi K. "Characterization of Leukocyte-Platelet Rich Fibrin, a Novel Biomaterial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3749.

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Autologous platelet concentrates represent promising innovative tools in the field of regenerative medicine and are successfully used in oral surgery. Several commercial systems exist that generate various forms of platelet concentrates including Platelet-rich plasma (PRP) and Platelet-rich fibrin (PRF). The alpha- granules of entrapped platelets release a variety of peptide growth factors that promotes healing. Usually PRP is a suspension that can be injected into the site of injury or used as a gel with the addition of thrombin (PRP-gel). In contrast Choukroun’s L-PRF is a dense fibrin based

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Barona, Intriago Maria Fernanda. "Regulation of gingival fibroblast gene expression by leukocyte and platelet rich fibrin." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62647.

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Objectives: Leukocyte and Platelet-Rich Fibrin (L-PRF), a new clinically used blood product, is rich in leukocytes and platelets embedded in a high-density fibrin network. L-PRF has shown some clinical promise to promote gingival wound healing. In gingival surgeries where L-PRF is being used, it will be in direct contact with human gingival fibroblasts (HGFs) of the surgical flap. However, little is known about the combined effects of the growth factors and cells present in L-PRF on HGFs. We hypothesized that L-PRF regulates expression of key wound healing genes in HGFs. Thus, our aim was to i

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Peck, Mogammad Thabit. "An analysis of the morphological and biological properties of a novel human leukocyte- and platelet- rich concentrate." University of the Western Cape, 2018. http://hdl.handle.net/11394/6841.

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Philosophiae Doctor - PhD<br>Wound healing is a complex process that involves several overlapping and interacting biological pathways. The consequences of delayed or abnormal wound healing may result in tissue formation that has impaired function or structural abnormalities. As a result, clinicians have sought ways to enhance this process. Recently, the use of autologous platelet concentrates have become popular in the management of wound healing sites. However, controversy exists as to how these biomaterials should be prepared and applied. We therefore sought to investigate whether a b

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Glazier, Thomas F., Thomas C. Waldrop, John C. Gunsolley, and Robert Sabatini. "The Role of Leukocyte-Platelet Rich Fibrin in Human Alveolar Ridge Preservation: A Randomized Clinical Trial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3735.

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PURPOSE: The aim of this study is to examine the healing of intact extraction sockets grafted with leukocyte-platelet rich fibrin (L-PRF) as compared to sockets grafted with freeze-dried bone allograft (FDBA) and a resorbable collagen barrier membrane (RCM). METHODS: This prospective randomized, examiner blinded pilot study included 17 subjects randomized to two treatment groups. Serum total cholesterol, low density lipoprotein (LDL), 25-hydroxyvitamin-D3, and platelet counts were determined preoperatively in all subjects. The experimental arm consisted of 8 posterior tooth-bounded intact extr

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Schuldt, Luisa Antonia. "In vitro evaluation of the effects of leukocyte-platelet rich fibrin on disinfection of a rough implant surface." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62613.

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Objectives: Peri-implantitis is a frequent and serious clinical problem affecting between 1 and 47% of implants. Bacterial contamination of the roughened implant surface plays a major role in the etiology and progression of the disease. Successful treatment of peri-implantitis requires disinfection of the rough implant surface. There is no generally accepted protocol for implant disinfection. Autologous leukocyte and platelet-rich fibrin (L-PRF) membranes can be produced from autologous human blood via a one-step centrifugation procedure. It was hypothesized that the antimicrobial defense syst

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Jiménez, Aristizabal Román Fulgencio. "Validar el uso de fibrina rica en plaquetas y leucocitos (L-PRF) en caballos para aumentar los procesos de regeneración tisular." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457513.

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Una segona generació de PRP ha estat proposada com a biomaterial per cirurgia humana. Aquesta substancia es nomenada Fibrina Rica en Plaquetes i Leucòcits (L-PRF) i s’obté de sang venosa recollida en tubs sense anticoagulants i centrifugada d’immediat a baixes acceleracions. Durant el procés hi ha activació plaquetària quan les plaquetes entren en contacte amb el vidre dels tubs i la fibrina polimeritza. Algunes cèl·lules queden atrapades dins d’aquesta malla de fibrina, predominantment plaquetes i leucòcits I part de les investigacions en aquesta tesi porten a conclusions importants sobre

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Resende, Margarida Reynolds de Sousa. "Utilização de laser ou de fibrina rica em plaquetas no maneio de feridas do membro distal equino." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/18819.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>As feridas do membro distal equino que cicatrizam por segunda intenção, são potencialmente de cicatrização lenta. O objetivo do estudo consistiu na avaliação do efeito terapêutico do laser ou da aplicação de fibrina rica em plaquetas (PRF) na cicatrização de feridas por segunda intenção de membros distais de equinos e de etiologia traumática, em comparação com o método convencional na prática clínica. Todas as feridas (n=9) possuíram diferentes dimensões iniciais e tempos desde a sua lesão até à primeira observação clínica. Considera

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Calixto, Carlos Alberto [UNIFESP]. "Plasma rico em plaquetas (PRP) por meio de centrífuga de bancada." Universidade Federal de São Paulo (UNIFESP), 2011. http://repositorio.unifesp.br/handle/11600/9936.

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Made available in DSpace on 2015-07-22T20:50:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-05-25<br>INTRODUÇÃO: O plasma rico em plaquetas (PRP) é a concentração autóloga de plaquetas em pequeno volume de plasma, obtido por centrifugação do sangue total com anticoagulante, sendo considerada importante fonte de fatores de crescimento (FC). A sua utilização enfatiza a regeneração tecidual. OBJETIVO: Obter o plasma rico em plaquetas (PRP) por meio de centrífuga de bancada. MÉTODOS: Foram coletos 40ml de sangue total de oito voluntários, para 72 testes, divididos em três grupos (gru

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Ana, Tadić. "Uticaj preparata koncentrovanih faktora rasta na regeneratorne i reparatorne procese u postekstrakcionim ranama." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110072&source=NDLTD&language=en.

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Ekstrakcija zuba je intervencija prilikom koje se zub vadi iz svog leži&scaron;ta u zubnoj alveoli. Rana koja nastaje kao posledica ove intervncije je takvog oblika da njene ivice nije moguće približiti jednu drugoj , te zarasta per secundam intentionem. Ekstrakcija zuba ima za posledicu mnogobrojne promene na tvrdim i mekim tkivima alveolarnog nastavka u periodu od nekoliko meseci do godinu dana nakon intervencije. Savremena stomatologija se i dalje intenzivno bavi proučavanjem procesa zarastanja ekstrakcione rane iz potrebe da se &scaron;to bolje razumeju promene u tkivu koje nastaju po gubi

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Pedrosa, Ana Sofia Fontes Barbosa. "O Uso de PRF (Platelet Rich Fibrin) na Regeneração Periodontal." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/107254.

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Pedrosa, Ana Sofia Fontes Barbosa. "O Uso de PRF (Platelet Rich Fibrin) na Regeneração Periodontal." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/107254.

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Pedro, Mara Simões. "Platelet-rich fibrin membranes resistance to traction comparing A-PRF versus A-PRF+." Master's thesis, 2021. http://hdl.handle.net/10400.14/34572.

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Objetivos: O presente estudo teve como objetivo comparar as propriedades mecânicas de resistência à tração e estrutura entre as membranas produzidas por A-PRF (Advanced- Platelet Rich Fibrin) e A-PRF+ (Advanced-Platelet Rich Fibrin+). Materiais e métodos: Recorrendo à colheita de sangue de um dador saudável sem história de uso de anticoagulantes ou imunossupressores, realizou-se a preparação das membranas seguindo as indicações protocolares definidas na literatura para A-PRF e A-PRF+. De um N=16/grupo, 13 membranas de A-PRF e 12 de A-PRF+ foram submetidas ao teste de tração, para a obt

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Monteiro, Ana Margarida de Lima Alegre. "Leukocyte and platelet-rich fibrin in the regeneration of periodontal infrabony defects." Master's thesis, 2017. http://hdl.handle.net/10316/81854.

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Trabalho de Projeto do Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina<br>Introdução: O crescente conhecimento na área da Periodontologia levou ao desenvolvimento de várias técnicas regenerativas, mas também ao reavivar do uso de concentrados plaquetários no tratamento de defeitos periodontais infraósseos. Objetivos: Esta revisão sistemática pretende perceber se a abordagem com fibrina rica em plaquetas e leucócitos (L-PRF) melhora os resultados clínicos e radiológicos, se promove uma melhor qualidade de vida pós-operatória ao paciente e, também, qual o estado da ar

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Ferreira, Helena Sofia Andrade Estrada Soares. "L-PRF no Tratamento de Recessões Gengivais." Master's thesis, 2018. http://hdl.handle.net/10316/81919.

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Trabalho Final do Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina<br>Introdução: No recobrimento radicular de recessões gengivais (RG) têm sido procuradas alternativas ao enxerto de tecido conjuntivo (ETC), de modo a evitar a morbilidade induzida na sua recolha. As membranas de fibrina rica em leucócitos e plaquetas (L-PRF) têm sido testadas pela sua facilidade de obtenção e aporte em fatores de crescimento.Objetivo: Este trabalho pretende fazer uma revisão sistematizada sobre a utilização do L-PRF em associação a técnicas cirúrgicas de recobrimento radicular, bem c

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Loureiro, Ana Teresa Gaspar Nunes. "Regeneração periodontal de defeitos de furca com Fibrina Rica em Plaquetas E Leucócitos (L-PRF)." Master's thesis, 2018. http://hdl.handle.net/10316/82191.

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Trabalho Final do Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina<br>Introdução: Os defeitos de furca representam um desafio na área regenerativa periodontal, tendo sido propostas diversas abordagens na expetativa de diminuir a imprevisibilidade do seu tratamento. Com o desenvolvimento de protocolos otimizados e simplificados, os concentrados plaquetários autólogos (CP) têm ganho maior visibilidade, com uma potencial aplicação na regeneração destas lesões. Objetivos: Este trabalho tem como objetivo avaliar a eficácia e aplicabilidade dos concentrados plaquetários, e

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Ko, Pai-Hung, and 柯百鴻. "Development of platelet-rich fibrin (PRF) as biodegradation scaffold for application in cartilage engineering." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/88097638314545469537.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>96<br>Because of articular cartilage has a limited ability for self- repair. Thus, treatment of cartilage lesions is a challenge. Osteoarthritis (OA), is known as degenerative joint disease and a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints. This thesis investigates to incorporate PRF that involves developmental signals into fibrin for use in cell biological studies and as a regeneration matrix employing tissue-engineering (TE). The goal is to explore the fibrin gel that adds PRF scaffold for in vitro cult

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LIU, KENG-CHANG, and 劉耿彰. "Effects of Platelet-Rich Fibrin (PRF) on Regeneration of Muscle, Bone, and Intervertebral Disc." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/p8z6hd.

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博士<br>東海大學<br>畜產與生物科技學系<br>107<br>Platelet concentrates including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are becoming innovative tools of regenerative medicine. Autologous PRP is derived from an individual's whole blood then centrifuged to remove red blood cells and leucocytes. The remaining plasma has a 5- to 10-fold higher concentration of growth factors than whole blood. These growth factors have been found to promote natural healing responses, and hence PRP is widely used in orthopedic and sports medicine to relieve pain in musculoskeletal injuries. Platelet-rich fibrin

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Said, Sherif Yousri. "The effect of platelet rich fibrin (PRF) on inter-proximal papillary height around dental implants." Thesis, 2016. https://hdl.handle.net/2144/26402.

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The original study design called for twenty patients. Fourteen patients with 13 implants have thus far been recruited for a prospective proof of principle study to assess the effect of addition of Platelet Rich Fibrin (PRF) on interproximal papillary height (I.P.H.) at the restorative line angles when used during the second stage uncovering procedure for dental implants. The secondary objective of this study was to assess the effect on the height of the direct interproximal tissue thickness (I.T.T.) at 6 weeks following uncovering. Implants placed 3 or more months prior at Boston University S

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Cardoso, Cláudia Sofia Pinto e. Silva. "Coágulo A+-PRF convencional versus coágulo A+-PRF com protocolo PomPac: estudo comparativo do comprimento." Master's thesis, 2021. http://hdl.handle.net/10284/10377.

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Objetivo: Este estudo teve por objetivo compreender se a temperatura a que a colheita sanguínea é acondicionada no protocolo Advanced Plus-Platelet Rich Fibrin (A+-PRF), interfere nos resultados dimensionais dos coágulos. Materiais e Métodos: Dez voluntários, sem histórico de toma de anti-coagulantes e com intervenções cirúrgicas com tratamento com A+-PRF, foram submetidos a colheita de quatro tubos de sangue. Dois tubos colhidos sob protocolo convencional e outros dois sob protocolo PomPac. Após colheita procedeu-se à produção de coágulos segundo o protocolo de A+-PRF, previamente descrito n

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Liao, Chen-Hao, and 廖政豪. "The Effect of Platelet-rich Fibrin (PRF) Releasate Combined with Bone Marrow Stem Cells on Osteoporosis with a Mouse Model." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/39221159761768569916.

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碩士<br>臺灣大學<br>獸醫學研究所<br>103<br>Stem cells are a kind of undifferentiated cells which may differentiate into other cell types. And they can also divide indefinitely into stem cell line, but may become cancer cells at about the tenth generation. We collect the bone marrow stem cells (BMSCs) and differentiate BMSCs into osteoblast in vitro after cell sorting by flow cytometer. Platelet-rich fibrin (PRF) is a natural source of growth factors, which contains a large amount of growth factors that can facilitate bone regeneration, Such as: TGFb-1 (Transforming growth factor) , PDGF (platelet-derived

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Jong, Yu-Tang, and 鐘毓棠. "The effect of Platelet-rich fibrin (PRF) extract and Adipose-derived stem cells (ADSCs) reconstruction on rabbit corneal damage reconstruction." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/59495347814739468158.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>104<br>Platelet-rich fibrin (PRF), a biologic material isolated from centrifugal blood contains many cytokines and growth factor. Stem cells is undifferentiated cell which has potential to differentiate into different cell types. In 1986, Schermer found corneal stem cells in the limbus and the reports of stem cells reconstruct on cornea was increased. In our studies, we found PRF that can help stem cells express migration, proliferation, differentiation, angiogenesis, collagen synthesis and even regeneration of new tissue. In this study, cornea damage model were ind

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Otero, Ada Isis Pelaez. "Sinus lift associated with second generation of autologous platelet concentrates : a systematic review." Master's thesis, 2021. http://hdl.handle.net/10400.14/34807.

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Introduction. The purpose of this systematic review was lift to analyze the available literature of clinical studies involving sinus lifting and comparing the efficiency of 2 nd autologous platelet concentrates (APC) generation related to its effects in bone gain and to clarify the regenerative efficacy of APC in sinus lift procedure, whether alone or as a coadjutant to other bone graft materials. Material and methods. This systematic review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines (1) with the focused question b

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Vilela, Beatriz Figueira. "Retalho de avanço coronal utilizando membrana de PRF versus enxerto de tecido conjuntivo: revisão narrativa." Master's thesis, 2021. http://hdl.handle.net/10284/10825.

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Esta revisão tem como principal objetivo avaliar o prognóstico de um retalho de avanço coronal utilizando uma membrana PRF comparativamente a um enxerto de tecido conjuntivo. Assim, são analisadas diversas variáveis, tais como profundidade de recessão, profundidade de sondagem, índice de placa, largura da recessão, nível de inserção clínica, altura de tecido queratinizado, espessura de tecido queratinizado, recobrimento radicular parcial e completo e desconforto pós operatório. Foram incluídos artigos em inglês, publicados entre 2015 e 2020 foram procurados em três bases de dados distintas (Pu

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Chan, Ming-Yun, and 詹明澐. "The Effect of Platelet-rich Fibrin （PRF） Releasate Combined with Bone Marrow Stem Cells on Acute Kidney Injury by ischemia reperfusion with a Rat Model." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/27715562812479594001.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>104<br>Kidney disease affects millions of people in the world because of increasing incidence and prevalence and the high costs of treatment. Renal injury is mainly caused by toxic and ischemic injury. Renal ischemia-reperfusion occurs in different clinical situations including kidney transplantation, cardiopulmonary bypass, aortic bypass surgery, accidental trauma, sepsis, and hydronephrosis. Post ischemia-reperfusion kidney is characterized by the accumulation of extracellular matrix and usually results in a loss of function when normal parenchyma is replaced by fib

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Bastos, Fernando Duque Lessa. "Efetividade da L–PRF na elevação do assoalho do seio maxilar: revisão sistemática e metaanálise." Master's thesis, 2017. http://hdl.handle.net/10284/6115.

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Objetivo: Analisar a efetividade da L–PRF (fibrina rica em plaquetas e leucócitos) na neoformação óssea em procedimentos cirúrgicos de elevação do assoalho do seio maxilar com fixação simultânea de implantes por meio da revisão sistemática da literatura e metaanálise. Materiais e Métodos: Uma pesquisa bibliográfica digital e manual, sem restrição de idioma, data ou desenho do estudo, foi realizada na PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, literatura cinzenta e periódicos em linha, até janeiro de 2017. Foram selecionados estudos em humanos onde a L–PRF foi utilizada como único mat

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tsung, Lia0 han, and 廖漢聰. "Combination of guided osteogenesis with autologous platelet-rich fibrin glue (PRFG) and mesenchymal stem cell for reconstruction of mandibular defects." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/38747058540196698334.

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碩士<br>長庚大學<br>顱顏口腔醫學研究所<br>95<br>Background: Mandibular bone defects commonly occur after trauma or cancer surgery. These defects are traditionally treated by autologous bone grafts to restore function and aesthetic appearance. However, harvesting autogenous bone grafts is traumatic and is associated with significant donor site morbidity and unpredictable resorption of the bone grafts. Guided tissue regeneration (GTR) and tissue-engineered bone regeneration are potential alternatives. This study examined whether a combination of autologous patelete-rich fibrin glue (PRFG) with mesenchymal ste

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Marimoutou, Adrien Gabriel Babou. "Fibrina rica em plaquetas versus enxerto de tecido conjuntivo no tratamento da recessão gengival." Master's thesis, 2019. http://hdl.handle.net/10284/8425.

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Objetivo: Avaliar a pertinência da utilização da fibrina rica em plaquetas no tratamento da recessão gengival comparativamente ao enxerto de conjuntivo. Materiais e Métodos: Realizou-se uma pesquisa bibliográfica recorrendo à base de dados da PubMed. Apenas foram incluídas ensaios clínicos randomizados sem limites temporais e sem limites línguisticos. A pesquisa resultou num total de 7 artigos. Resultados: Através da análise dos resultados dos autores, de forma não estatística, a fibrina rica em plaquetas apresentou ser eficiente no tratamento de recessões gengivais de classe I e II de

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Liu, Yu-Hao, and 劉宇豪. "Combination of Bone Marrow Derived Stem Cells and Dental Pulp Derived Stem Cells with Platelet-rich Fibrin Releasate (PRFr) to Repair and Regenerate Sciatic Nerves Injury." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/583eg3.

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碩士<br>國立臺灣大學<br>分子暨比較病理生物學研究所<br>104<br>The injury of sciatic nerves was a serious problem to the patients, such as costing money for treatment and even worse to change their life. However, there were many limitations in the traditional therapy and as a result a better treatment should be found out. Recently, the cell-based therapy has been focused to repair the broken-down nerves. In the mean times, using Platelet-rich fibrin releasate (PRFr) to repair damaged organs was an insight in Regenerative Medicine. Bone marrow derived stem cells (BMSCs) and Dental pulp derived stem cells (DPSCs) and

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Chien, Chian-Shiang, and 簡千翔. "Comparison of platelet-enriched fibrin glue and platelet rich plasma gel biodegradable fibrin scaffolds for tissue engineering of cartilage." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/86903733837355446754.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>97<br>Articular cartilage has a limited self-regenerative capacity. Tissue engineering using autologous chondrocytes implantation (ACI) provide an promising strategy on cartilage repair, seeding cell on scaffold to culture healthy chondrocytes in vitro, then re-inject into articular cartilage. Platelet-enriched fibrin (PEF) glue are making from autolous platelet rich plasma (PRP). It is a natural materials that has biocompatible and biodegradable properties, can provide 3D environment allow cells do attachment, secretes multiple cytokines for chondrogenesis diffe

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Su, Sheng-Fen, and 蘇聖分. "Effects of Matrine and Platelet-Rich Fibrin on Mouse Embryo Development." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/8j53m4.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>105<br>Martine (Sophocarpidine ) is a nature alkaloid derived from Traditional Chinese Medicine-Sophora root (the root of sophoraflavescens Ait), and it has been documented Compendium of Materia Medica. Matrine has widely used in the viral infection and skin treatment. Recent studies have demonstrated that matrine induces apoptosis in cancer cells and inhibits the melanoma cell proliferation. The potential toxicity of matrine on mouse embryo development however is still unclear. In this study, blastocysts were cultured in the presence or absence of matrine (0, 25, 5

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Pedro, Beatriz Mancebo Vieira. "The effect of platelet rich fibrin in oral surgery: a literature review." Master's thesis, 2017. http://hdl.handle.net/10451/29500.

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Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2017<br>To summarize the relevant literature regarding the clinical efficacy of Platelet Rich Fibrin (PRF) in oral surgery and its applications in clinical practice. Introduction: One of the challenges facing clinical research is the development of bioactive surgical additives regulating inflammation and increasing healing. Platelet Rich Fibrin is a second-generation platelet concentrate developed by Dr. Joseph Choukroun, in 2001. The combined properties of fibrin, platelets, leucocytes, growth factors

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Jiing-Huei and 趙璟徽. "The effects of platelet rich fibrin on human osteoblasts and the clinical application." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/79834835772888408365.

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碩士<br>中山醫學大學<br>口腔醫學研究所<br>99<br>Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which allows one to obtain fibrin membranes enriched with platelets and growth factors, after an anticoagulant-free blood harvest. However, limited information is currently available concerning the biologic effects of PRF on osteoblasts. The aim of this study is to provide clear evidence for the clinical use of PRF, we investigated the biologic effects of PRF on human osteoblasts. PRF was obtained by centrifugation at 2700 rpm for 12 minutes with a PC-O2 table centrifuge. At first, light mic

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Pascoal, Martim de Almeida Nóbrega Correia. "Leucocyte versus advanced-platelet rich fibrin membranes resistance to traction : a comparative study." Master's thesis, 2019. http://hdl.handle.net/10400.14/28469.

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Objetivos: Este estudo teve por objectivo fazer uma comparação directa da resistência à tração entre membranas produzidas com o protocolo L-PRF (Leucocyte-Platelet Rich Fibrin) e A-PRF (Advanced-Platelet Rich Fibrin). Materiais e Métodos: Após a colheita de sangue de uma pessoa saudável e sem histórico de toma de anticoagulantes, procedeu-se à produção de membranas segundo os protocolos de L-PRF e A-PRF, previamente descritos na literatura. De seguida, as membranas (13 para cada protocolo) foram submetidas a um teste de tração, para os quais foram obtidos valores de tração máxima e de tração

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Ching, Paula Carmela O., and 秦小玫. "Platelet-Rich Fibrin/Decellularized Cartilage Powderin Articular Cartilage Defect Regenerationin a Rabbit Model." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/fb7t94.

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Fernandes, Gustavo Vicentis de Oliviera. "A utilização da Fibrina Rica em Plaquetas (PRF) em cirurgia de levantamento de seio maxilar." Master's thesis, 2018. http://hdl.handle.net/10284/7215.

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Este trabalho tem por objetivo fazer uma revisão narrativa da literatura sobre a PRF em cirurgias de ganho ósseo no levantamento do seio maxilar (LSM), e do seu potencial em uso separado ou associado a enxerto ósseo. Foram utilizadas as bases de dados Pubmed, SciELO e Google Scholar, na qual foram avaliados os resumos e incluídos os artigos adequados ao tema. Com o surgimento do PRF em 2001, vários trabalhos têm sido publicados sobre o seu uso potencial em cirurgias, nomeadamente no LSM, utilizado isoladamente ou em associação com enxerto ósseo. Vários autores verificaram que a PRF favor

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Hsieh, Song-Huan, and 謝松桓. "The Effect of Platelet Rich Fibrin on Velvet Cell Proliferation in Formosan Sika Deer." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5vzwu6.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>106<br>Recent studies have shown that stem cells can be isolated from various tissues such as bone marrow, adipose tissue. Stem cell therapy is a most efficient means of medical; it can be used as a mammalian organ repair and cell renewing. Embryonic stem cell therapy is ethical controversy, but adult stem cells therapy is noncontroversial. However, the primary problem is that not all tissues have encountered isolated stem cells, and the percentage of stem cells isolated is very low. Deer velvet regeneration in mammalian organs is rare. The key to understand that st

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Chih-Lung and 吳志隆. "Platelet-rich fibrin increases cell attachment, proliferation, and collagen-related proteins expression of human osteoblasts." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/94277273421683896394.

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博士<br>中山醫學大學<br>醫學研究所<br>100<br>Background: Platelet-rich fibrin (PRF) by Choukroun’s technique is derived from anautogenous preparation of concentrated platelets without any manipulation. PRF was found to increase osteoblast growth and proliferation. However, the underlying mechanisms are not yet completely understood. This study was to determine the effects of PRF on cell attachment, proliferation, phosphorylated Akt, heat shock protein 47 (HSP47), and lysyl oxidase (LOX) expression on human osteoblasts. Methods: Blood collection was carried out from ten healthy volunteers. Cell attachment a

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Lin, Sheng-Chuan, and 林昇全. "Application of Autologous Mesenchymal Stem Cells, Coenzyme Q10 and Platelet-rich Fibrin for Acute Myocardial Infarct in Porcine." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/66771978083689275034.

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博士<br>國立屏東科技大學<br>熱帶農業暨國際合作系所<br>100<br>Abstract Student ID: P9822001 Title of Thesis: Application of Autologous Mesenchymal Stem Cells、 Coenzyme Q10 and Platelet-rich Fibrin for Acute Myocardial Infarct in Porcine Total Page: 104 Name of Institute: Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology. Graduate Date: July, 2012 Degree Conferred: Ph.D. Name of Student: Sheng-Chuan Lin Advisor: Professor Yan-Der Hsuuw Professor Tzong-Fu Kuo The Contents of Abstract in This Thesis: Stem cells therapy is the “proces

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Peer, Fatima. "Comparing clinical outcomes of connective tissue grafts to platelet rich fibrin in gingival recession treatment: an extended case series." Thesis, 2018. https://hdl.handle.net/10539/25233.

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A Research Report submitted to the School of Oral Health Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, in partial fulfilment of the requirements for the degree of Master of Science in Dentistry, February 2018.<br>Aim This study set out to evaluate the clinical and aesthetic outcomes of connective tissue grafts (CTG) to platelet rich fibrin (PRF) in treating gingival recession. It was hypothesised that PRF could be as effective as CTGs in treating recession with improved aesthetic results. To the best of my knowledge this clinical st

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Tzu-ChingYu and 余紫菁. "Polycaprolactone Combined with Platelet-Rich Fibrin and Adipose-Derived Stem Cells for Endothelialized Small Caliber Vascular Graft in Bioreactor System." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/22198699607515836921.

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碩士<br>國立成功大學<br>生物醫學工程學系<br>104<br>According to the report published from World Health Organization (WHO), cardiovascular diseases (CVDs) rank number one the cause of death globally. Moreover, there were estimated 17.5 million people died from CVDs in 2012. The patients suffering serious vascular disease have to receive the vascular graft surgery. There are two common vessel substitute resources, one is autologous vessels, and the other is artificial vascular graft. Comparing to autologous vessel, the artificial vessel has some advantages, such as low-cost and easy to manufacture. However, the

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Tseng, Chia-Chuan, and 曾嘉川. "A novel method for rabbit stifle joint cartilage regeneration with injectable platelet-rich fibrin releasate and bone marrow stem cell." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/63171296554476847001.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>102<br>Abstracts Osteoarthritis, is a degenerative joint disease accompanied with non-inflammatory articular cartilage lesion, losing of extracellular matrix and develop into cracks, erosion, subchondral sclerosis, osteophytes and loss of joint function eventually. Unlike other connective tissues, articular cartilage does not contain blood vessels so it does not have the ability to regenerate and repair; therefore, materials that promote articular cartilage regeneration are important in tissue engineering studies. Mesenchymal stem cells (MSCs) can be found and isolate

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Huang, JunJie, and 黃俊杰. "The Effect of Patelet-rich Fibrin (PRF) Releasate Combines with Bone marrow-derived Mesenchymal Stem Cells on Type I Diabetes Mellitus with a Mouse Model." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/35801456600852919957.

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碩士<br>臺灣大學<br>獸醫學研究所<br>103<br>Diabetes Mellitus is a serious disease in which the body cannot properly control the amount of sugar in your blood because it does not have enough insulin. And it can be divided into Type I diabetes and Type II diabetes. Type I diabetes mellitus is a chronic disease characterized by the autoimmune destruction of insulin-secreting pancreatic beta-cells, which results from the body''s failure to produce enough insulin and gives rise to fasting and postprandial hyperglycemia. The classic symptoms are polyuria (excessive urination), polydipsia (excessive th

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Lin, Ming-Cheng, and 林明正. "Functionalized bone-graft substitutes with platelet-rich fibrin and bone marrow-derived mesenchymal stem cells for enhanced bone tissue regeneration-with rabbit animal model." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/nnnx72.

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碩士<br>臺北醫學大學<br>醫療器材產業碩士專班<br>105<br>Functionalized bone-graft substitutes with platelet-rich fibrin and bone marrow-derived mesenchymal stem cells for enhanced bone tissue regeneration-with rabbit animal model. Porous bone grafting materials, which possess excellent bioactivity, biocompatibility and osteoconductivity, have played an important role in bone tissue regeneration. This study examined whether a combination of bone graft extender (BG), beta-tricalcium phosphate/hydroxyapatite (40/60) composite, with platelet-rich fibrin (PRF), bone marrow-derived mesenchymal stem cells (BMSCs) and/o

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