Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: Polyethylene glycol 400 (PEG400).
Artykuły w czasopismach na temat „Polyethylene glycol 400 (PEG400)”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych artykułów w czasopismach naukowych na temat „Polyethylene glycol 400 (PEG400)”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj artykuły w czasopismach z różnych dziedzin i twórz odpowiednie bibliografie.
1
Ishibashi, Riko, Rio Matsuhisa, Mio Nomoto, et al. "Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice." Microorganisms 11, no. 8 (2023): 1882. http://dx.doi.org/10.3390/microorganisms11081882.
Pełny tekst źródłaStreszczenie:
Polyethylene glycol (PEG) is a commonly used dispersant for oral administration of hydrophobic agents. PEG is partly absorbed in the small intestine, and the unabsorbed fraction reaches the large intestine; thus, oral administration of PEG may impact the gut microbial community. However, to the best of our knowledge, no study evaluated the effects of PEG on gut commensal bacteria. Herein, we aimed to determine whether oral administration of PEG modifies the gut microbiota. Administration of PEG400 and PEG4000 altered gut microbial diversity in a concentration-dependent manner. Taxonomic analysis revealed that Akkermansia muciniphila and particularly Parabacteroides goldsteinii were overrepresented in mice administered with 40% PEG. PEG400 administration ameliorated the high-fat diet (HFD)-induced obesity and adipose tissue inflammation. Fecal microbiome transplantation from PEG400-administered donors counteracted the HFD-induced body and epididymal adipose tissue weight gain, indicating that PEG400-associated bacteria are responsible for the anti-obesity effect. Conversely, carboxymethyl cellulose, also used as a dispersant, did not affect the abundance of these two bacterial species or HFD-induced obesity. In conclusion, we demonstrated that oral administration of a high concentration of PEG400 (40%) alters the gut microbiota composition and ameliorates HFD-induced obesity.
2
Suzuk, Takayuki, Thi Thi Nge, Yusuke Matsumoto, and Tatsuhiko Yamada. "Effects of wood meal particle size and polyethylene glycol 400 content on glycol lignin production." BioResources 20, no. 1 (2024): 1286–300. https://doi.org/10.15376/biores.20.1.1286-1300.
Pełny tekst źródłaStreszczenie:
Glycol lignin (GL) produced via acidic solvolysis of cedar wood meal with polyethylene glycol (PEG) is a highly functional material. In this study, the effects of wood meal particle size and amount of PEG added on the properties of PEG400-modified GLs (GL400s) were examined. For this purpose, cedar wood meal with four different particle sizes ranging between 0.18 and 2.00 mm and PEG400 at liquid ratios of 5 and 3 with respect to the wood meal were used. Acidic solvolysis at 140 °C successfully decreased the amount of solid residue with increasing GL400 yield and reaction time at both liquid ratios of 5 and 3. Overall, wood meal size remarkably affected the physical properties of GL400s at low PEG400 content (liquid ratio 3). In addition, the glass transition temperature Tg and thermal flow temperature Tf increased with decreasing wood meal size. Consequently, GL400s with varying thermal properties (Tg = 63 to 97 °C, Tf = 109 to 149 °C) were successfully prepared by adjusting the PEG400 liquid ratios and wood meal size. The data will support the development of a stable manufacturing process for the mass production of GL.
3
Firdaus, Ansari Ammara, and K. C. Juglan. "Investigation on Acoustic Parameters of Monosodium Glutamate Food Preservative in an Aqueous Solution of PolyEthylene Glycols (400 and 600)." E3S Web of Conferences 453 (2023): 01045. http://dx.doi.org/10.1051/e3sconf/202345301045.
Pełny tekst źródłaStreszczenie:
This paper aims to examine the impact of social media on mental health. Aqueous monosodium glutamate (MSG) was mixed with polyethylene (PEG400 and PEG600), and the resulting mixture was weighed and subjected to acoustic density and velocity measurements. These combinations ranged from 0.01-0.03 mol.kg−1 in concentration. The Anton Paar DSA 5000 M was used to take the readings, which showed a temperature range of 288.15K to 318.15K. The experimental data was used to derive several acoustic and thermodynamic properties, such as intermolecular free length, acoustic impedance, adiabatic compressibility, Wada’s constant, Rao’s constant, and Vander Waal’s constant. To better comprehend the intermolecular processes occurring in a ternary mixture of monosodium glutamate (MSG), polyethylene glycols (PEG400, and PEG600), these simulations were carried out. The goal of these calculations was to produce this result.
4
Zhang, Dan, Fei Qiu, and Yong Diao. "Preparation and Characterization of Chitosan-Poly(MA-PEG400-SA) Nanoparticles as Drug Carrier." Advanced Materials Research 528 (June 2012): 39–42. http://dx.doi.org/10.4028/www.scientific.net/amr.528.39.
Pełny tekst źródłaStreszczenie:
In order to prepare chitosan-based nanoparticles for drug delivery, we synthesis chitosan-poly(methacryloyl polyethylene glycol succinic acid, MA-PEG400-SA) nanoparticles in aqueous solution via template polymerization. The structure of the chitosan-poly(MA-PEG400-SA) nanoparticles was characterized by FT-IR spectra, and the particles size and surface charge were analyzed by zetasizer, respectively. The average size of chitosan-poly(MA-PEG400-SA) nanoparticles was approximate 325 nm, and the surface charge was 33mv. Using hydrophilic drug 5-FU as the model drug, the drug loading efficiency was about 6%. In the further study, we will optimize the synthesis conditions and study on the drug release properties of the nanoparticles.
5
Lehmacher, Roman, and Claus Feldmann. "Polyol-Mediated Synthesis of Nitrogen-Containing Carbon-Dots from Tetracyanobenzene with Intense Red Fluorescence." Nanomaterials 9, no. 10 (2019): 1470. http://dx.doi.org/10.3390/nano9101470.
Pełny tekst źródłaStreszczenie:
Nitrogen-containing C-dots were prepared by heating (160 °C, 1 h) 1,2,4,5-tetracyanobenzene (TCB) in polyethylene glycol 400 (PEG400). The as-prepared monocrystalline C-dots were 2–4 nm in diameter and contained 24.4 wt. % of nitrogen. They showed intense fluorescence under excitation at 400–500 nm as well as under excitation at 600–700 nm. In addition to an excitation-wavelength-depending emission at 400 to 650 nm, the emission spectra exhibited a strong emission peaking at 715 nm, whose position was independent from the wavelength of excitation. For this deep-red emission a remarkable quantum yield of 69% was detected. The synthesis of nitrogen-containing C-dotswas completely performed in the liquid phase. Moreover, the C-dots could be directly dispersed in water. The resulting aqueous suspensions of PEG400-stabilized nitrogen-containing C-dots also showed intense red emission that was visible to the naked eye.
6
Wang, Han Min, Xue Li Gao, Bao Wei Su, and Cong Jie Gao. "Preparation and Characterization of Antimicrobial PES Ultra-Filtration Membrane Modified with Capsaicin." Advanced Materials Research 356-360 (October 2011): 2338–43. http://dx.doi.org/10.4028/www.scientific.net/amr.356-360.2338.
Pełny tekst źródłaStreszczenie:
The polyethersulfone ultra-filtration membrane was prepared by phase inversion method using polyethersulfone(PES), polyethylene glycol 400(PEG400) and N，N- dimethylamide(DMAC) as materials, and was modified by adding a capsaicin monomer named MBHBA which possess antibacterial property. The effects of MBHBA content on the ultra-filtration membrane performance were discussed. The results showed that the addition of MBHBA monomer effectively increased the membrane flux. And the modified membrane had strong inhibitory activity against Escherichia coli.
7
Zhao, Mei, Pengjiao Wang, Xiaodong Sun, et al. "Detrimental Impacts of Pharmaceutical Excipient PEG400 on Gut Microbiota and Metabolome in Healthy Mice." Molecules 28, no. 22 (2023): 7562. http://dx.doi.org/10.3390/molecules28227562.
Pełny tekst źródłaStreszczenie:
Polyethylene glycol 400 (PEG400) is a widely used pharmaceutical excipient in the field of medicine. It not only enhances the dispersion stability of the main drug but also facilitates the absorption of multiple drugs. Our previous study found that the long-term application of PEG400 as an adjuvant in traditional Chinese medicine preparations resulted in wasting and weight loss in animals, which aroused our concern. In this study, 16S rRNA high-throughput sequencing technology was used to analyze the diversity of gut microbiota, and LC-MS/MS Q-Exactive Orbtriap metabolomics technology was used to analyze the effect of PEG400 on the metabolome of healthy mice, combined with intestinal pathological analysis, aiming to investigate the effects of PEG400 on healthy mice. These results showed that PEG400 significantly altered the structure of gut microbiota, reduced the richness and diversity of intestinal flora, greatly increased the abundance of Akkermansia muciniphila (A. muciniphila), increased the proportion of Bacteroidetes to Firmicutes, and reduced the abundance of many beneficial bacteria. Moreover, PEG400 changed the characteristics of fecal metabolome in mice and induced disorders in lipid and energy metabolism, thus leading to diarrhea, weight loss, and intestinal inflammation in mice. Collectively, these findings provide new evidence for the potential effect of PEG400 ingestion on a healthy host.
8
Ma, Bing-Liang, Yan Yang, Yan Dai, Qiao Li, Ge Lin, and Yue-Ming Ma. "Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example." RSC Advances 7, no. 5 (2017): 2435–42. http://dx.doi.org/10.1039/c6ra26284h.
Pełny tekst źródła
9
Zhang, Qiang, Ying Dong Cheng, Yu Liu, Shu Qin Yan, and Ming Zhong Li. "Study on Silk Fibroin Gelation: Effect of Polyalcohol." Advanced Materials Research 175-176 (January 2011): 137–42. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.137.
Pełny tekst źródłaStreszczenie:
The Bombyx mori silk fibroin gel with three dimensional structures is an important form to be developed for tissue engineering materials. In this paper, silk fibroin gels were prepared with adding polyalcohol into silk fibroin solution. The gel structure was analyzed by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The results demonstrated that when adding more than 100% of polyalcohol, both of glycerol and polyethylene glycol 400 (PEG400) can accelerate the gelation process markedly. With the increase of the percentage of PEG400 and glycerol, it promoted silk fibroin molecules to cluster rapidly and inhibit silk fibroin molecules transforming from the random coil or α-helix to β-sheet in a ratio of 900% especially. Silk fibroin gels containing 100% of polyalcohol had more uniform morphology and the pores distributed uniformly.
10
Iemsam-Arng, Jayanant, Saowaluk Jangkena, Kunat Suktham, Ratjika Wongwanakul, Onuma Unger, and Sukanya Thepwatee. "Effect of Co-Solvents on Physicochemical Properties and Stability of Areca Nut Extract Loaded Nanoemulsions." Key Engineering Materials 862 (September 2020): 40–45. http://dx.doi.org/10.4028/www.scientific.net/kem.862.40.
Pełny tekst źródłaStreszczenie:
Areca nut extract provides a variety of pharmacological effects that are beneficial for skincare applications. A nanoemulsion of areca nut extract was developed to mask the intense color and to improve the water solubility of the extract. This work studied the impact of a co-solvent on the characteristics and stability of the nanoemulsion. Our former optimized nanoemulsion was modified by adding a common co-solvent, propylene glycol or polyethylene glycol 400 (PEG400), to the formula. Phase separation, particle characteristics, antioxidant activity, in vitro cytotoxicity, and stability of the modified nanoemulsion were evaluated. This work has shown the successful encapsulation of areca nut extract with a great improvement of stability, well-maintained antioxidant activity and low toxicity on normal human skin fibroblast.
11
Simchareon, Weeraya, Thanaporn Amnuaikit, Prapaporn Boonme, Wirach Taweepreda, and Wiwat Pichayakorn. "Properties of Deproteinized Natural Rubber Latex Blended Films with Glycol Penetration Enhancers for Pharmaceutical Applications." Advanced Materials Research 747 (August 2013): 87–90. http://dx.doi.org/10.4028/www.scientific.net/amr.747.87.
Pełny tekst źródłaStreszczenie:
The blended film of deproteinized natural rubber latex (DNRL) with hydroxypropyl methylcellulose (HPMC) and dibutylphthalate (DBP) provided good properties that suitable for pharmaceutical applications. However, this film had successfully been confirmed in transdermal use only for high skin permeable drugs. In this study, this film was further modified to look forward on the delivery of a low permeable drug. Glycols, one group of chemical penetration enhancer, were investigated to blend in this film in order to enhance the low permeable drug through the skin. Various concentrations (5, 10, 15, and 20 parts per hundred of rubber (phr)) of ethylene glycol (EG), propylene glycol (PG), and polyethylene glycol 400 (PEG400) were blended with DNRL/HPMC/ DBP mixtures before film construction by solution-casting technique. The modified films were evaluated in thickness, tensile strength, peel strength, tack adhesive, swelling and erosion ratios, moisture uptake, and compatibility. These blended films provided good characters in elasticity, adhesive properties, hydrophilicity, and compatibility. Their thickness could be controlled to be uniform. These new blended films were suitable to use in the further study for low permeable drug delivery through the skin.
12
Das, Arijit, M. P. Taraka Prabhu, and Nandini Sarkar. "Synthesis, characterization, and in vitro DPPH radical scavenging assay study of PEG-capped carbon nanoparticles derived from Butea monosperma flower extract." Advances in Natural Sciences: Nanoscience and Nanotechnology 13, no. 1 (2022): 015002. http://dx.doi.org/10.1088/2043-6262/ac5498.
Pełny tekst źródłaStreszczenie:
Abstract In this work, the core carbon nanoparticles (BM CNs) and polyethylene glycol 400 (PEG400)-capped BM CNs were synthesised from Butea monosperma flower extract via the facile direct heating method. They were investigated for their intriguing properties and in vitro antioxidation activity in comparison with Carica papaya seed (CPS) extract via DPPH assay. The CNs were characterised by DLS, XRD, HR-TEM, TGA, FT-IR, UV–vis spectral analysis and quantum yield measurement. The PEGylated CNs demonstrated decent quantum yield, favourable size, and turbostratic carbon phase apart from better stability and dispersion nature as compared to the uncapped entity. The mildly stable uncapped sample with zeta potential −17.9 mV featured its extensively aggregated form, unlike the capped sample with −23.0 mV zeta potential, which sheds light on its enhanced stability by PEG400. Antiradical capacities of the CNs in comparison with CPS extract demonstrated the PEG400-bound nanomaterial of its superior antiradical activity against the other two controls. This study provides an insight into the novel polymer-CNs’ potent antioxidant property which can be further explored for its incorporation in targeted drug delivery and other biomedical applications.
13
Mundada, Atish, and Jasmine Avari. "Permeability studies of Damar Batu free films for transdermal application." Chemical Industry and Chemical Engineering Quarterly 15, no. 2 (2009): 83–88. http://dx.doi.org/10.2298/ciceq0902083m.
Pełny tekst źródłaStreszczenie:
Damar Batu (DB) looks like stone with black or dark brown color inside. Due to its film forming ability it is used in the manufacture of paper, wood, varnishes, lacquers, polishes and additives for beverages. In the present study the permeability of free films of DB casted from chloroform solution containing different plasticizers was studied with a view to developing a suitable rate controlling membrane for transdermal use. The free films of DB were prepared by a mercury substrate technique and dibutyl sebacate (DBS), dibutyl phthalate (DBP), polyethylene glycol 400 (PEG400) and propylene glycol (PG) were tried as plasticizers. DB films were then evaluated for uniformity of thickness, moisture absorption, water vapour transmission, tensile strength, percentage elongation and folding endurance. Permeability characteristics of free films of DB were studied using diltiazem hydrochloride (DH) as a model drug. Little variation in film thickness ensured the uniformity of the films. DBS produces tough DB films with more tensile strength. Drug diffusion through the free films followed zero order kinetics. The films plasticized with PEG400 showed higher permeability for DH compared with other films. The order of decrease of permeability of plasticized films with plasticizers was PEG400 > PG > DBP > DBS. Diffusion of drugs through the free films of DB was extended over a longer period of time at a controlled rate. DB seems to be a promising rate controlling membrane for the transdermal application.
14
Elwakkad, Noha Yehia, and Khaled Mohamed Heiza. "Mechanical properties of self-curing concrete (SCUC)." Challenge Journal of Concrete Research Letters 10, no. 1 (2019): 1. http://dx.doi.org/10.20528/cjcrl.2019.01.001.
Pełny tekst źródłaStreszczenie:
According to lack of water, labor self curing concrete (SCUC) is necessary in construction projects. In this study, it is focuses on concrete application with new admixture to achieve SCUC. The present study involves the use of shrinkage reducing admixture polyethylene glycol (PEG 400) in concrete which helps in self curing and helps in better hydration and hence strength. The effect of admixture (PEG 400) on water retention, compressive strength, split tensile strength and modulus of rupture by varying the percentage of PEG by weight of cement from 0% to 1% were studied for M1 and M2 mixes. It was found that using PEG400 with dosage 0.3%, 0.5% gives an early strength to the concrete. It was also found that 0.5% of PEG 400 by weight of cement was the optimum for both M1 and M2 mixes.
15
Chen, Weisheng, Qinqin Zhang, Xiaoqi Lin, Kaisen Jiang, and Dezhi Han. "The Degradation and Repolymerization Analysis on Solvolysis Liquefaction of Corn Stalk." Polymers 12, no. 10 (2020): 2337. http://dx.doi.org/10.3390/polym12102337.
Pełny tekst źródłaStreszczenie:
One of the most effective and renewable utilization methods for lignocellulosic feedstocks is the transformation from solid materials to liquid products. In this work, corn stalk (CS) was liquified with polyethylene glycol 400 (PEG400) and glycerol as the liquefaction solvents, and sulfuric acid as the catalyst. The liquefaction conditions were optimized with the liquefaction yield of 95.39% at the reaction conditions of 150 °C and 120 min. The properties of CS and liquefaction residues (LRs) were characterized using ATR–FTIR, TG, elemental analysis and SEM. The chemical components of liquefied product (LP) were also characterized by GC–MS. The results indicated that the depolymerization and repolymerization reaction took place simultaneously in the liquefaction process. The depolymerization of CS mainly occurred at the temperature of <150 °C, and the repolymerization of biomass derivatives dominated at a higher temperature of 170 °C by the lignin derivatives repolymerization with cellulose derivatives, hemicellulose derivatives and PEG400 and self-condensation of lignin derivatives. The solvolysis liquefaction of CS could be classified into the mechanism of electrophilic substitution reaction attacked by the hydrogen cation.
16
Stanciauskaite, Monika, Mindaugas Marksa, Liudas Ivanauskas, and Kristina Ramanauskiene. "Balsam Poplar Buds: Extraction of Potential Phenolic Compounds with Polyethylene Glycol Aqueous Solution, Thermal Sterilization of Extracts and Challenges to Their Application in Topical Ocular Formulations." Antioxidants 11, no. 9 (2022): 1771. http://dx.doi.org/10.3390/antiox11091771.
Pełny tekst źródłaStreszczenie:
Phenolic compounds of natural origin have been valued for their beneficial effects on health since ancient times. During our study, we performed the extraction of phenolic compounds from balsam poplar buds using different concentrations of aqueous polyethylene glycol 400 solvents (10–30% PEG400). The aqueous 30% PEG400 extract showed the best phenolic yield. The stability of the extract during autoclave sterilization was evaluated. The extract remained stable under heat sterilization. Ophthalmic formulations are formed using different concentrations (8–15%) of poloxamer 407 (P407) together with hydroxypropyl methylcellulose (0.3%), sodium carboxymethyl cellulose (0.3%) or hyaluronic acid (0.1%). Physicochemical parameters of the formulations remained significantly unchanged after sterilization. Formulations based on 12% P407 exhibited properties characteristic of in situ gels, the gelation point of the formulations was close to the temperature of the cornea. After evaluating the amount of released compounds, it was found that, as the concentration of polymers increases, the amount of released compounds decreases. Formulations based on 15% P407 released the least biologically active compounds. Sterilized formulations remained stable for 30 days.
17
Kormin, Shaharuddin, and Anika Zafiah M. Rus. "Preparation and Characterization of Biopolyol from Liquefied Oil Palm Fruit Waste: Part 1." Materials Science Forum 882 (January 2017): 108–12. http://dx.doi.org/10.4028/www.scientific.net/msf.882.108.
Pełny tekst źródłaStreszczenie:
Liquefaction is known to be an effective method for converting biomass into a biopolyol. The biomass liquefaction of oil palm fruit waste (OPFW) in the presence of liquefaction solvent/polyhydric alcohol (PA): Ethylene glycol (EG), polyethylene glycol 400 (PEG400) and glycerol using sulfuric acid as catalyst was studied. For all experiments, the liquefaction was conducted at 150°C and atmospheric pressure. The mass ratio of OPFW to liquefaction solvents used in all the experiments was 1/2, 1/3 and 1/4. The results revealed that almost 50% of the oil palm fruit waste converted into liquid product within 2 hours at 150°C with OPFW/PA ratio of 1/4. Biopolyol produced under different condition showed viscosities from 210 to 650 Pa.s. The result in this study may provide fundamental information on integrated utilization of oil palm fruit waste via biomass liquefaction process.
18
Srisuk, Rapeeporn, Chaisiri Kitpaosong, Suchart Siengchin, and Rapeephun Dangtungee. "Hot Solvent Extraction Method for Recycle Epoxy Resin in Waste Printed Circuit Board with Polyethylene Glycol." Materials Science Forum 857 (May 2016): 524–29. http://dx.doi.org/10.4028/www.scientific.net/msf.857.524.
Pełny tekst źródłaStreszczenie:
Waste printed circuit board (WPCB) from waste electrical and electronic equipment (e-waste) can be recycled a precious metal part while a non-metal part was burned or landfilled, which normally generated toxic substance of organic component to environment. The research work aimed to recycle epoxy resin by hot solvent chemical extraction. Polyethylene glycol 400 (PEG400) and ethylene glycol (EG), at 180°C, were mainly using as solvent and sodium hydroxide (NaOH) as a catalyst. Extraction method was reflux technique. The thermogravimetric analysis (TGA), Specific viscosity, and Fourier transform infrared spectroscopy (FT-IR) methods were investigated and discussed. The TGA result showed that the organic composition was 40.73%wt. The maximum of percent yield was 97.89% at non-metal WPCB/PEG, equal to 0.05 g/ml. Moreover, the extracted product presented a functional group close to virgin epoxy resin according to the peak of FT-IR data. The recycled epoxy resin could be formed well on specimen by virgin epoxy resin and hardener filled with 50% recycled extraction product.
19
Jin, Yanqiao, Chunmei Lai, Jiaqing Kang, Xianze Lu, Jin Liu, and Qiu-Feng Lü. "Liquefaction of cornstalk residue using 5-sulfosalicylic acid as the catalyst for the production of flexible polyurethane foams." BioResources 14, no. 3 (2019): 6970–82. http://dx.doi.org/10.15376/biores.14.3.6970-6982.
Pełny tekst źródłaStreszczenie:
Due to the huge demand for as well as the limited reserves of fossil resources, renewable biomass that can be converted into chemicals has become a global research focus. In this paper, cornstalk residue was liquefied using a mixture of polyethylene glycol with a molecular weight of 400 g/mol (PEG400) and ethylene carbonate (EC) as the liquefaction reagent and 5-sulfosalicylic acid (SSA) as the catalyst. The liquefaction product of the cornstalk residue (CRL) was used to replace petroleum polyols to prepare flexible polyurethane foams. The results showed that the optimum liquefaction conditions were as follows: PEG400/EC was 7.5:2.5 (w/w), the ratio of liquid/solid was 5:1 (w/w), the liquefaction temperature was 160 C, the mass of SSA was 4 g, and the liquefaction time was 60 min. The hydroxyl number and residue content of the CRL at optimal conditions were 315.7 mg KOH/g and 4.5%, respectively. The compressive strength and apparent density of the polyurethane foam, which was prepared by 90 wt% CRL, 10 wt% commercial polyether GE-220, and methylene diphenyl diisocyanate, were 205.6 kPa and 0.075 g/cm3, respectively.
20
Yan, Xiao Lin, and Ke Bing Wang. "Studies on the Processing Conditions for Preparation of Polyol Using Beet Pulp." Applied Mechanics and Materials 189 (July 2012): 7–11. http://dx.doi.org/10.4028/www.scientific.net/amm.189.7.
Pełny tekst źródłaStreszczenie:
The catalyzed liquefaction degradation of beet pulp (BP) had been studied in the system of solid silicotungstic acid and polyethylene glycol 400 (PEG400)/glycerol (GLY), in which the solid silicotungstic acid served as the catalyst, and the latter was the complex liquefacient. This paper investigated the influence of processing conditions of BP liquefaction on the liquefaction reaction and the properties of liquefaction product. The results showed that BP had a good liquefaction effect, and the optimum liquefaction processing conditions were founded as follows: the weight ratio of PEG 400/glycerol was 4:1, the liquefaction temperature was 175oC, the catalyst amount was 8%wt, the solid-liquid weight ratio was 1:12, and the liquefaction time was 135 min. In these conditions, it was found that the best liquefaction rate would reach 99.5%, the hydroxyl and acid values of liquefaction mixtures were 52-82mg/g and 0.61-0.75mg/g respectively, the final products were lower hydroxyl value plant-based polyol.
21
Srividhya, Raghavendran. "STRENGTH STUDIES ON SELF CURING HIGH PERFORMANCE FIBRE REIFORCED CONCRETE (HPFRC)." International Journal of Engineering Research and Modern Education Special Issue, April 2017 (2017): 147–52. https://doi.org/10.5281/zenodo.570968.
Pełny tekst źródłaStreszczenie:
High performance concrete (HPC) is one of the prevailing techniques which have become popular due to its mechanical and durability properties. To enhance the property, fibre reinforcement is providing with steel fibre and also overcome the insufficient curing problem due to human irregularity during the period of curing the self curing methodology have been adopted. In this study mechanical property of self curing HPFRC is examined with varies percentage of self curing agent of Polyethylene Glycol (PEG400) with a constant proportion of silica fume and steel fibre. The steel fibre of aspect ratio 50mm is adopted for minimizing the cracks in concrete and improving strength, durability, impact, toughness etc. The HPC of grade M60 is prepared with water cement ratio of 0.3 and PEG400 varies from 0% to 1.5% at 0.5% intervals with and without using steel fibres and replacing cement with 6% of silica fume. To enhance the workability of HPC, super plasticizer (conplast 430) at a range of 1.8% of cement was used. Mechanical properties like compressive strength, split tensile strength, flexural strength and modulus of elasticity were examined at 3 days, 7 days and 28 days to evaluate the optimum percentage of PEG 400 with and without steel fibre.
22
Al-Jabali, Hebah Mohammad, Walid Fouad Edris, Shady Khairy, Ghada N. Mohamed, Hebatallah A. Elsayed, and Ahmed A. El-Latief. "Impact of PEG400–Zeolite Performance as a Material for Enhancing Strength of the Mechanical Properties of LECA/Foamed Lightweight Concrete." Infrastructures 9, no. 9 (2024): 149. http://dx.doi.org/10.3390/infrastructures9090149.
Pełny tekst źródłaStreszczenie:
A versatile building material, foamed concrete is made of cement, fine aggregate, and foam combined with coarse aggregate. This study provides a description of how constant coarse aggregate replacement (50%) of LECA and foamed concrete, which are lightweight concrete types, by zeolite as a filler and PEG-400 as a plasticizer, water retention agent, and strength enhancer affect the mechanical properties of the cement. A study that examined the characteristics of cellular lightweight concrete in both its fresh and hardened forms was carried out for both foamed concrete and LECA concrete. In order to do this, a composite of zeolite and polyethylene glycol 400 was made using the direct absorption method, and no leakage was seen. Zeolite was loaded to a level of 10% and 20% of the total weight in cement, while 400 g/mol PEG was used at levels of 1%, 1.5%, and 2% of the cement’s weight. Various mixtures having a dry density of 1250 kg/m3 were produced. Properties like dry density, splitting tensile strength, and compressive strength were measured. An increase in the amount of PEG400–zeolite was seen to lower the workability, or slump, of both foamed and LECA concrete, while the replacement of aggregate by zeolite resulted in an exponential drop in both compressive and flexural strengths.
23
Tubtimsri, Sukannika, and Yotsanan Weerapol. "Development of Nifedipine Amorphous Solid Dispersion Composed of Surface-Active Agents." Key Engineering Materials 901 (October 8, 2021): 35–39. http://dx.doi.org/10.4028/www.scientific.net/kem.901.35.
Pełny tekst źródłaStreszczenie:
The amorphous solid dispersions (ASDs) containing amino methacrylate copolymer and surface-active agents were prepared to improve the nifedipine (NDP) dissolution. The different types of surface-active agent i.e., polysorbates 80, sodium lauryl sulfate (SLS) and polyethylene glycol (PEG) 400 were used. In order to evaluate the ASDs formulation,powder X-ray diffractometry and thermal analysis to characterize NDP crystallinity in ASDs and the dissolution study of NDP have been performed to compare the dissolution profiles. The ASDs were kept for 6 months to investigate the stability. In the X-ray diffraction pattern, no peak was observed in all samples of ASDs. No peak was found in sample of all ASDs from the thermograms. These results suggest that the drug may be molecularly dispersed in matrix of amino methacrylate copolymer. The drug dissolution at 120 min, from ASDs without surface-active agent and NDP powder were 58.31% and 17.95%, respectively. The dissolved NDP from ASDs composed of SLS, polysorbate 80 and PEG400 were 96.25%, 88.86% and 75.32%, respectively. These results may occur due to the reduction of surface tension, the addition of the low amount of high efficiency of surface-active agent e.g., SLS (compared with PEG400 and polysorbate 80) provided the higher NDP dissolution. The content analysis of NDP in selected ASDs was studied at the end of 3 and 6 months, the NDP content remained unchanged after storage.
24
Zhang, Jin Ping, Meng Hao Du, and Li Song Hu. "Liquefaction of Bamboo Polyhydric Alcohols and its Application in Polyurethane Foam Materials." Advanced Materials Research 781-784 (September 2013): 632–35. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.632.
Pełny tekst źródłaStreszczenie:
Liquefy bamboo powder with the liquefacient of polyethylene glycol 400 and glycerin, and use the obtained liquefied product for preparing polyurethane foam materials. Results indicate that: 1) liquefaction ratio will be the highest when the proportion of PEG400 and glycerin is 80/20; 2) when the bamboo is liquefied, liquefied effect will be better if the mass ratio of bamboo powder and polyhydric alcohols is above 1: 4; 3) liquefaction ratio will be the highest when it is liquefied for 120min with 3% mass fraction of the catalyst--sulfuric acid and 170°C liquefied temperature; 4) hydroxyl value of the liquefied product of bamboo powder is 333.8mgKOH/g; 5) through the adjustment of foaming formula and technology, compressive strength of polyurethane plate with the thickness of 10mm and with the density of polyurethane foam materials of 0.4g/cm3, which is obtained from bamboo powder liquefied product is 17MPa, and the elasticity modulus is 1000MPa.
25
Malavi, R. Bhavsar* Anand D.Savkare. "ENHANCEMENT OF AQUEOUS SOLUBILITY OF CARVEDILOL BY LIQUISOLID TECHNIQUE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 537–49. https://doi.org/10.5281/zenodo.1036494.
Pełny tekst źródłaStreszczenie:
The aim of this study was to improve the solubility of the poorly soluble drug Carvedilol by delivering the drug as a liquisolid Pellets. There are several techniques to enhance the dissolution of poorly soluble drugs. Among them, the technique of liquisolid compact is most promising technique towards novel aim. Polyethylene glycol 400 (PEG400) used as solvent, Avicel pH 102 as carrier, and Kollidon VA 64 as the coating material. The liquisolid compact were prepared by Spheronization and extrusion to form liquisolid pellets. Further Pellets were evaluated for flow properties, disintegration time, drug content, and dissolution, DSC, SEM and XRD. The results for dissolution studies showed that liquisolid Pellets demonstrate significantly higher drug release rates than those of marketed ones. This was due to an increase in wetting properties and surface of drug available for dissolution. Increased wetting properties and dissolution rates leads to enhance solubility. The liquisolid technique appears to be a promising approach for improving the solubility of poorly soluble drugs.
26
Jabir, Saba Abdulhadee, and Halah Talal Sulaiman. "PREPARATION AND CHARACTERIZATION OF LAFUTIDINE AS IMMEDIATE RELEASE ORAL STRIP USING DIFFERENT TYPE OF WATER-SOLUBLE POLYMER." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 249. http://dx.doi.org/10.22159/ijap.2018v10i5.28292.
Pełny tekst źródłaStreszczenie:
Objective: The objective of the present study was to design and optimize oral fast dissolving film (OFDF) of practically insoluble drug lafutidine in order to enhance bioavailability and patient compliance especially for a geriatric and unconscious patient who are suffering from difficulty in swallowing.Methods: The films were prepared by a solvent casting method using low-grade hydroxyl propyl methyl cellulose (HPMC E5), polyvinyl alcohol (PVA), and sodium carboxymethyl cellulose (SCMC) as film forming polymers. Polyethylene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as a plasticizer to enhance the film forming properties of the polymer. Tween 80 (1% solution) and poloxamer407 were used as a surfactant, citric acid as a saliva stimulating agent, and croscarmellose as a super disintegrant. Films were then tested for both physical (weight variation, thickness, surface pH, drug content) and mechanical (folding endurance, tensile strength, percent elongation, Young's modulus) characteristics. In vitro disintegration, time and drug release profile were also determined for each formula.Results: Films were found to be satisfactory when evaluated for both physical and mechanical characterizations. The surface pH of all the films was found to be within the range of salivary pH 6.8. The USP dissolution apparatus type II (paddle type) was used for in vitro drug release studies. The optimized formulation F13 gave 100 % of drug released at 2 min. It also showed satisfactory surface pH (6.2±0.2), drug content (100.1±0.01%), the disintegration time of (7.0±0.5) seconds and the time needed for 80% of medication to be released (T80%) was 0.96 min.Conclusion: Lafutidine OFDF was formulated using HPMC E5 as film-forming a polymer with PEG400 as a plasticizer. Combination of tween80 (1% solution) and poloxamer407 as a surfactant were used in the presence of croscarmellose as a super disintegrant. The chosen OFDF disintegrates within seven seconds, releases the drug rapidly and gives an action.
27
Wang, Qingyue, and Nuerjiamali Tuohedi. "Polyurethane Foams and Bio-Polyols from Liquefied Cotton Stalk Agricultural Waste." Sustainability 12, no. 10 (2020): 4214. http://dx.doi.org/10.3390/su12104214.
Pełny tekst źródłaStreszczenie:
Cotton is planted on a large scale in China, especially in the Xinjiang Region. A large amount of agricultural waste from cotton plants is produced annually, and currently poses a disposal problem. In this study the product after liquefaction of cotton stalk powder was mixed with diphenylmethane diisocyanate to prepare polyurethane foams. The effects of the liquefaction conditions on the properties of the polyols and polyurethane foams produced using cotton stalk were investigated. The optimal processing conditions for the liquefied product, considering the quality of the polyurethane foams, were studied as a function of the residue fraction. Bio-polyols with promising material properties were produced using liquefaction conditions of 150 °C, reaction time of 90 min, catalyst content of 3 wt.%, and 20 w/w% cotton stalk loading. We investigated the optimal processing conditions for producing bio-foam materials with mechanical properties comparable to those of petroleum-based foam materials. This study demonstrated the potential of cotton stalk agricultural waste for use as a feedstock for producing polyols via liquefaction. It was shown that polyethylene glycol 400 (PEG400) and glycerin can be used as alternative solvents for liquefaction of lignocellulosic biomass, such as cotton stalk, to produce bio-polyol and polyurethane foams.
28
Gennari, Chiara G. M., Antonella Casiraghi, Francesca Selmin, and Francesco Cilurzo. "Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration." Pharmaceutics 17, no. 1 (2025): 88. https://doi.org/10.3390/pharmaceutics17010088.
Pełny tekst źródłaStreszczenie:
Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, Tg, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, v/v), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties.
29
Ismail, Nurul Qistina, Nur Aina Azmi, Noor Fazliani Shoparwe, Nadiah Ameram, and Abdul Hafidz Yusoff. "Characterization Effect of Polysulfone Membranes with Different Molecular Weight of Polyethylene Glycol Additives." IOP Conference Series: Earth and Environmental Science 1102, no. 1 (2022): 012085. http://dx.doi.org/10.1088/1755-1315/1102/1/012085.
Pełny tekst źródłaStreszczenie:
Nowadays, membrane technology has gaining popularity in biotechnology, food processing, water treatment, pharmaceutical and semiconductor industries. It been reported as a potential technique for separation due to their low-cost process, does not used many chemical and energy sufficient. However, there is less study about polysulfone (PSF) used as a polymer based in membrane filtration with polyethylene glycol (PEG) as additives in different molecular weight (Mw: 400, 600, 1500, and 4000 Da). Therefore, this study has been conducted to investigate the effect of different molecular weight of PEG in terms of thermal stability, hydrophilicity, and porosity. For methodology, PSF polymer was fabricated with PEG and Dimethylacetamide (DMAc) act as solvent via wet phase inversion method. The physical, thermal and chemical characterization were analysed using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and laboratory testing of contact angle, water uptake, and porosity. The result showed improvement in fabricated membranes hydrophilicity than pure membrane. PEG with high molecular weight demonstrated the higher membrane hydrophilicity, good thermal stability (38.40%), contact angle (54°), higher water uptake (385.23%), and higher porosity (82.72%). As conclusion, PSF with addition of the high molecular weight of PEG (PEG4000) can improve the performance of membrane filtration.
30
Muter, Sarah Sabah, and Athmar Dhahir Habeeb. "Preparation and evaluation of gastroretentive floating unfolding film of baclofen." Pharmacia 72 (May 14, 2025): 1–12. https://doi.org/10.3897/pharmacia.72.e147835.
Pełny tekst źródłaStreszczenie:
Baclofen, a muscle relaxant used for severe pain management, has a narrow absorption window limiting its bioavailability. Enhancing its gastric residence time could potentially improve its absorption and effectiveness. Floating drug delivery systems are a promising approach to prolong drug retention in the stomach. This study aimed to develop a floating bilayer film for the sustained release of baclofen. The core of the film was formulated with baclofen, PVP K90, sodium alginate, and PEG 400 as a plasticizer, while the controlled release layer contained Eudragit RS100 or RLPO with different plasticizers (DBP and PEG 400). All formulations were evaluated for weight uniformity, drug content, thickness, folding ability, swelling, and <i>in vitro</i> drug release. The optimized formula had a 98% drug release within 12 hours, floated effectively for 24 hours, and followed zero-order kinetics.
31
Hemati, Hamide, Fateme Haghiralsadat, Mahdie Hemati, Ghasem Sargazi, and Nastaran Razi. "Design and Evaluation of Liposomal Sulforaphane-Loaded Polyvinyl Alcohol/Polyethylene Glycol (PVA/PEG) Hydrogels as a Novel Drug Delivery System for Wound Healing." Gels 9, no. 9 (2023): 748. http://dx.doi.org/10.3390/gels9090748.
Pełny tekst źródłaStreszczenie:
Hydrogel scaffold has been widely applied as drug delivery systems for treating skin injuries. However, the poor drug loading and rapid drug release of hydrogel restricted their application. In the current study, we present a nanoliposome containing sulforaphane (SF) as a nano-drug delivery system that is encapsulated within the scaffold hydrogel system to overcome these limitations and improve wound healing. The hydrogel substrate consisting of 10% polyvinyl alcohol (PVA)/5% polyethylene glycol 400 (PEG400) was prepared by the freeze–thaw method, and the nanoliposomal system was manufactured by the thin film hydration method at different molar ratios of cholesterol: SPC: DPPC: DSPE-PEG2000. The nanoliposome and hydrogel system was characterized by physicochemical analyses. The findings achieved from the optimization of the sulforaphane-loaded nanoliposome (SFNL) displayed an increase in the molar ratio of SPC, leading to a higher entrapment efficiency and a gradual release profile. Narrow size distribution, optimal electrical charge, and the lack of molecular interactions between SF and nanoliposome components in the FTIR analysis make SFNL a suitable drug delivery system for the wound healing process. The obtained SFNL-encapsulated freeze–thawed hydrogel system has sufficient and specific swelling ability at different pH values and increased mechanical strength and elongation. Additionally, the release pattern of SFNL at different pH values showed that the release of SF from liposomes depends on the pH value of the environment and accelerates in line with decreasing pH values. Encapsulation of nanoliposomal SF in the hydrogel structure provides a sustained release pattern of SF compared to its free form and increased as the pH environments continued to raise. The cytotoxicity and cell uptake of SFNL-loaded hydrogels against human skin fibroblasts (HFF cell line) were investigated. The in vitro analyses displayed that the toxicity properties of SF and SFNL were dose-dependent, and SFNL exhibited lower toxicity compared to free SF. Furthermore, the proper cell compatibility of the prepared hydrogel against the HFF cell line was confirmed by the MTT assay. These findings imply that the hydrogel scaffold loaded with SFNL may have wound-healing potential.
32
Yabuta, Ryoto, Norihisa Kobayashi, and Kazuki Nakamura. "Electrofluorochromic Devices Based on Electrochemical Valance Change of Europium Complex in Polyether Matrices." ECS Meeting Abstracts MA2024-02, no. 38 (2024): 2571. https://doi.org/10.1149/ma2024-02382571mtgabs.
Pełny tekst źródłaStreszczenie:
Chromogenic materials, in which optical properties such as luminescence and absorption are altered by external stimuli such as light, heat, and electricity, have potential applications in chemical sensors, biochemical labels, molecular memory, and display devices. Electrofluorochromic (EFC) materials, in which wavelength and/or intensity of their photoluminescence are controlled by electrochemical redox reactions, are innovative materials because they can rapidly and repeatedly convert electrical inputs into visual signals. These EFC phenomena were reported by using small molecules, conjugated polymers, inorganic compounds, and luminescent metal complexes. Among the luminescent metal complexes, the lanthanide(III) complexes are composed of a luminescent center of Ln(III) ions and surrounding antenna ligands with sufficient light-absorbing ability. They have attractive photoluminescence properties such as characteristic and narrow emission bands in the visible-near infrared (Vis-NIR) region, long emission lifetimes, and high transparency in the visible region due to the large pseudo-Stokes shift. In particular, Eu complexes have relatively stable trivalent (Eu3+) and divalent (Eu2+) states. The Eu3+ state is characterized by intense and long-lived red luminescence induced by f–f transitions and is extensively applied to biosensors, light-emitting materials, etc. On the other hand, Eu2+ is known to show broad and blue luminescence induced by d–f transitions, from the excited state of 4f65d1 to the ground level state of 8S7/2 (4f7), and the emission of Eu2+ in inorganic matrices is applicable to various phosphor materials. However, Eu2+ is unstable in common solutions, which complicates the observation of its luminescence in solution state. Therefore, this study aims to control the luminescence between Eu3+ and Eu2+ by electrochemical redox reactions. It is recognized that the blue luminescence of Eu2+ can be stabilized by polyethers, such as crown ethers and polyethylene glycols[1]. By this stabilization, the Eu2+ state was expected to produce stalely and repeatedly by the electrochemical reduction of Eu3+ in polyethylene glycol solutions. Considering the EFC reaction of Eu compounds, this study focuses on the β-diketonate Eu complex that exhibits superior red luminescence properties of the Eu3+ state. The solution was prepared by dissolving the lithium trifluoromethanesulfonate (LiCF3SO3) (500 mM) as the supporting electrolyte, β-diketone type Eu(III) complex (Eu(hfa)3(H2O)2) (10 mM) as the emitting material in polyethylene glycol (MW = 400, PEG400). A three-electrode electrochemical cell with ITO electrode as the working electrode, Pt wire as the counter electrode, and Ag/Ag+ as the reference electrode was prepared using the Eu complex solution, and the electrochemical reaction behavior of the Eu(III) complex and the changes in luminescence properties during the reaction were measured. Then two-electrode electrochemical device was fabricated by sandwiching Eu complex solution between the two ITO electrodes (ITO-ITO device) to evaluate photoluminescence (PL) properties under the application of reduction voltage. When the CV measurement using the constructed three-electrode cell structure, stable Eu2+/3+ reactions were not observed in the common electrochemical solvents (dimethyl sulfoxide, acetonitrile, and propylene carbonate). In contrast, relatively stable Eu2+/3+ changes were observed in the PEG400 electrolyte solution. This indicates that the electrochemically generated Eu2+ is more stable in the PEG400 solution than in the other solvents. The figure shows the emission spectra of the Eu(hfa)3(H2O)2 solution in the two-electrode ITO-ITO device under the application of reduction voltage. When a reduction voltage was applied for working electrode for 60 minutes, the emission bands of Eu2+ (430 nm) in the device significantly increased, and the red emission from Eu3+ (616 nm) simultaneously decreased as electrochemical reduction proceeded. Considering luminescence color, the intensity ratio of Eu2+ emission (430 nm, I 430) to Eu3+ emission (616 nm, I 616) was significantly improved using the two-electrode devices; the I 430 nm: I 616 nm ratio was 1: 100 for the three-electrode cell and 1: 2.5 for the two-electrode devices. Thus, changes in the luminescence color can be recognized by the naked eye after electrochemical reduction (Figure photos). These results show that electrochemical redox reaction of Eu complexes leads to a distinct change in luminescence color in PEG electrolyte by stabilizing Eu2+ state in liquid matrix. Figure 1
33
Mahdi, Hawraa A., Khalid W. Hameed, and Abdul-Jabbar A. Ali. "Extraction of Bovine Serum Albumin by Aqueous Two-Phase System Using PEG4000/Sodium Citrate and PEG8000/Sodium Phosphate." Al-Khwarizmi Engineering Journal 19, no. 2 (2023): 39–51. http://dx.doi.org/10.22153/kej.2023.04.001.
Pełny tekst źródłaStreszczenie:
Aqueous Two Phase System (ATPS) or liquid-liquid extraction is used in biotechnology to recover valuable compounds from raw sources. In Aqueous Two-Phase Systems, many factors influence the Partition coefficient, K, (which is the ratio of protein concentration in the top phase to that in the bottom phase) and the Recovery percentage (Rec%). In this research, two systems of ATPS were used: first, polyethylene glycol (PEG) 4000/Sodium citrate (SC), and the second, PEG8000/ Sodium phosphate (SPH), for the extraction of Bovine Serum Albumin (BSA). The behavior of Rec% and K of pure (BSA) in ATPS has been investigated throughout the study by the effects of five parameters: temperature, concentration of polyethylene glycol (PEG4000 and PEG8000), the concentration of Sodium citrate or Sodium phosphate, pH, and the addition of sodium chloride as a supporting agent. The recovery percentage of BSA and its partition coefficient are significantly influenced by these factors to various degrees. The most influential variable in this study is PEG concentration for both systems. In addition to the PEG concentration, the stabilizing impact of NaCl is a crucial factor. The interaction between biomolecules and PEG gets more hydrophobic as the PEG concentration is raised. In the first system (PEG4000/SC), the maximum recovery percentage and partition coefficient were 98.99% and 97.69, respectively, at 31°C, PEG4000 concentration 1.5g/10 ml, Sodium citrate concentration 2.7 g/10 ml, pH 10, and 0.5 M NaCl concentration. While in the second system (PEG8000/SPH), the maximum recovery percentage and partition coefficient was 98.93% and 92.12, respectively, at 31oC, PEG8000 concentration 1.5 g/10 ml, Sodium phosphate concentration 2.4 g/10 ml, pH 10, and concentration of NaCl 0.5 M.
34
Wang, Janell, Lawrence Chao, Steven Yeung, and Ying Huang. "Abstract A022: Limonene as a vehicle in topical delivery of carvedilol for skin cancer chemoprevention." Cancer Prevention Research 15, no. 12_Supplement_2 (2022): A022. http://dx.doi.org/10.1158/1940-6215.tacpad22-a022.
Pełny tekst źródłaStreszczenie:
Abstract Skin cancer is currently one of the most common cancers and is defined as an abnormal growth of the skin cells. The goal of this study is to develop a topical delivery system of carvedilol with limonene as the vehicle. Limonene is a major component found in the rinds of citrus fruits and other herbs. It is one of many natural compounds that have demonstrated inhibitory activity in different types of cancers such as breast, lung, and stomach cancer. Furthermore, limonene has shown to increase skin permeation of drugs including carvedilol. The soft agar colony formation assay was used to evaluate anchorage-independent growth of JB6 mouse epidermal cells. This assay tested concentrations of carvedilol (0.1, 1.0 and 10 μM); limonene (1.0, 10, 100 and 1000 μM); and a combination of carvedilol (1.0 μM) and limonene (1.0, 10 or 100 μM). Results demonstrated that carvedilol and limonene as single treatment inhibited colony formation. The combination of carvedilol and limonene showed higher colony inhibition than single treatment, although not statistically significant. Franz diffusion cell was used to test for permeation of the drug. The device has two chambers separated by a membrane, which in this case is rat skin. The drugs, in vehicles of 40% polyethylene glycol (PEG) 400 in PBS or 40% PEG400 in PBS plus 5% limonene were applied into the donor chamber while the samples are collected through the receptor chamber as the drug permeates through the skin. The samples were collected at 16 hours, 20 hours, and 24 hours. Results showed that limonene significantly increased permeation. Therefore, our data indicate that limonene was able to increase skin permeation and the chemopreventive activity of carvedilol. This new formulation will be further examined in animal models for its efficacy against UV-induced skin cancer. Citation Format: Janell Wang, Lawrence Chao, Steven Yeung, Ying Huang. Limonene as a vehicle in topical delivery of carvedilol for skin cancer chemoprevention [abstract]. In: Proceedings of the Second Biennial NCI Meeting: Translational Advances in Cancer Prevention Agent Development (TACPAD); 2022 Sep 7-9. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_2): Abstract nr A022.
35
Vespa, Simone, Pietro Del Biondo, Pasquale Simeone, et al. "Basophil Activation Test with Different Polyethylene Glycols in Patients with Suspected PEG Hypersensitivity Reactions." International Journal of Molecular Sciences 23, no. 23 (2022): 14592. http://dx.doi.org/10.3390/ijms232314592.
Pełny tekst źródłaStreszczenie:
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible for anaphylaxis in mRNA vaccines. Skin tests have been used in the allergological work-up programs for COVID-19 vaccine evaluation. However, the reproducibility of the skin prick test is time-dependent and the reactivity declines over time. Therefore, we combined the administration of the skin tests with the basophil activation test (BAT) using PEG2000, PEG4000 and DMG-PEG2000, where the BAT was considered positive when the percentage of activated basophils was higher than 6%, 5% and 6.5%, for PEG 4000, PEG2000 and DMG-PEG2000, respectively. To this end, among the subjects that underwent allergy counseling at the Allergy Unit of our Institution during the 2020/2021 vaccination campaign, 13 patients had a suggested medical history of PEG/drug hypersensitivity and were enrolled together with 10 healthy donors. Among the enrolled patients 2 out of 13 tested patients were positive to the skin test. The BAT was negative in terms of the percentages of activated basophils in all analyzed samples, but the stimulation index (SI) was higher than 2.5 in 4 out of 13 patients. These data evidenced that, when the SI is higher than 2.5, even in the absence of positivity to BAT, the BAT to PEG may be a useful tool to be coupled to skin tests to evidence even low-grade reactions.
36
Berghuis, Nila Tanyela, Deva Yani Panjaitan, Astra Agus Permana, and Osiliana Budiarto. "Synthesis of Polyethylene Glycol Esters from Oleic, Stearic, and Palmitic Acids as a Pour Point Depressant (PPD)." Molekul 19, no. 3 (2024): 417. https://doi.org/10.20884/1.jm.2024.19.3.8484.
Pełny tekst źródłaStreszczenie:
Polyethylene glycol (PEG) ester is a non ionic surfactant compound that could use a pour point depressant (PPD) for crude oil. Synthesis of PEG-ester with reflux and mono wave-50 methods through esterification fatty acid such as oleic acid, stearic acid, and palmitic acid with adding p-toluene sulfonic acid (p-TSA) as a catalyst. The product of esterification could be a mixture of monoester and diester. Synthesized PEG ester by reflux method resulted in higher yield than by mono wave-50 method. IR spectra analysis of PEG400-oleate, PEG400-stearate, and PEG400-palmitate show the presence of an absorption band at a wavenumber of around 1100 cm-1 that indicates the stretching vibration of the C-O ester. (LC-MS/MS) analysis that shows the molecular weight of PEG400-oleate was 845.6154 g/mol and, PEG400-stearate was 785.5952 g/mol. Mean, while PEG400-palmitate produced three ester compounds with different molecular weights: 741.5669 g/mol, 685.5057 g/mol, and 734.5208 g/mol. The pour point measurement results show that the PEG-fatty acid product in the range of 0.1% to 1% has not been able to reduce the pour point of the crude oil sample. Keywords: Esterification, FTIR, LC-MS/MS, Surfactant
37
Dong, Yeshuo, and Fanjun Meng. "Effect of polyethylene glycol on crystal growth and photocatalytic activity of anatase TiO2 single crystals." RSC Advances 10, no. 21 (2020): 12511–18. http://dx.doi.org/10.1039/d0ra01796e.
Pełny tekst źródłaStreszczenie:
Anatase TiO<sub>2</sub> crystals with different structures were synthesized. Experiments on the effect of polyethylene glycol show that the low molecular weight PEG (PEG400) can accelerate crystal differentiation and relieve the agglomeration of crystals.
38
S.R, Prof Suryawanshia. "USE OF SELF CURING AGENT POLYETHELENE GLYCOL (PEG400) IN M30 GRADE CONCRETE." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 05 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem34552.
Pełny tekst źródłaStreszczenie:
Now days concrete is the most widely used construction material due to its high strength and durability.Concrete needs a pleasant atmosphere for the development of strength, which will be provided by curing as prescribed by IS Code. Any neglectful in curing will effect the strength of the concrete. The water demand is increasing day by day and the sources are depleting. To counter this water demand we have made a study on ‘Self-Curing Concrete by the use of polyethylene glycol in M30 grade of concrete' which can drastically save the water used on the construction site.This study involves the use self curing agent-PolyEthylene Glycol (PEG400) which helps in self-curing of the concrete. Key Words: Concrete,Glass Fibers, Aggregate,Polyethylene Glycol,Superplastisizer
39
Qiu, Fei, Hui Yan, Lin Wei, and Yong Diao. "The Synthesis of Comb-Like Polymeric Prodrugs of 5-Fluorouracil Derivatives." Advanced Materials Research 421 (December 2011): 35–38. http://dx.doi.org/10.4028/www.scientific.net/amr.421.35.
Pełny tekst źródłaStreszczenie:
Two comb-like polymeric prodrugs of 5-fluorouracil derivatives (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were synthesized from monomers, methacryloyl (polyethylene glycol 5-fluorouracil acetyl) (MAA-PEG-5Fu) through radical polymerization using azobisisobutyronitrile (AIBN) as initiator in N,N-dimethyl formamide solution, which structures were confirmed by means of IR, 1HNMR, UV-Vis, MS and GPC spectroscopy. The drug loading rates of the two prodrugs (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were 25.51%, 10%, respectively.
40
Tang, Zhiyuan, Kuanjun Fang, Yawei Song, and Fuyun Sun. "Jetting Performance of Polyethylene Glycol and Reactive Dye Solutions." Polymers 11, no. 4 (2019): 739. http://dx.doi.org/10.3390/polym11040739.
Pełny tekst źródłaStreszczenie:
The jetting performance of dye inks determines the image quality, production efficiency, and lifetime of the print head. In the present study, we explored the jetting performance of mixed solutions of polyethylene glycol (PEG) and reactive dye by testing the visible absorption spectra, rheological properties, and surface tension, in addition to the observation of droplet formation. The results indicate that PEG macromolecules could change the aggregate groups of Red 218 molecules into smaller ones through hydrophobic interactions and separation effect. The addition of PEG into the dye solution increased the viscosity and decreased the surface tension. In the whole shear rate range tested, the 10% and 20% PEG400, as well as the 30% PEG200 dye solutions, showed good Newtonian fluid behavior. PEG macromolecules improved the droplet formation of the dye solutions. Increasing the PEG400 concentration to 30% and 40% resulted in elimination of the formation of satellites and the formation of ideal droplets at 10,000 Hz jetting frequency. A 30% PEG600-dye solution with the Z value of 4.6 formed the best spherical droplets at 10,000 Hz and produced perfect color images on cotton fabrics.
41
Chamsai, Benchawan, and Pornsak Sriamornsak. "Physical Stabilizing Effect of Biopolymers on Solid Dispersions Containing Indomethacin and Polyethylene Glycol." Advanced Materials Research 506 (April 2012): 307–10. http://dx.doi.org/10.4028/www.scientific.net/amr.506.307.
Pełny tekst źródłaStreszczenie:
Solid dispersions of poorly water-soluble drug, indomethacin (IMC), and carriers at a ratio of 1:9 were prepared by melting method. The carriers used in this study were polyethylene glycol 4000 (PEG4000), hydroxypropyl methylcellulose (HPMC) and pectin. The solid dispersions obtained were characterized by powder x-ray diffractometry (PXRD) and dissolution studies. PXRD patterns showed that all solid dispersions led to amorphous products while their physical mixture still showed the crystalline state of drug. Crystalline drug was clearly detectable in solid dispersion products containing only IMC and PEG4000 after storage for 2 months. The formulations with biopolymer (i.e., HPMC, pectin or their combination) showed no drug crystal after storage. More than 80% of IMC dissolved within 5 minutes for all formulations after preparation while less than 40% of IMC dissolved, within 5 minutes, from the formulations containing IMC, PEG4000 and HPMC after storage for 2 months. The slower drug dissolution may be due to the gel-forming properties of HPMC as well as the agglomeration of the products after storage. The results suggested that either HPMC or pectin in solid dispersions can help to prevent the crystallization of amorphous IMC in solid dispersion, probably by a polymer anti-plasticizing effect. Pectin showed superior stabilizing effect with no retardation effect on drug dissolution.
42
Iqbal, T. H., K. O. Lewis, and B. T. Cooper. "Diffusion of Polyethylene Glycol-400 across Lipid Barriers in Vitro." Clinical Science 85, no. 1 (1993): 111–15. http://dx.doi.org/10.1042/cs0850111.
Pełny tekst źródłaStreszczenie:
1. Polyethylene glycol has been used extensively as a probe to measure passive small-intestinal permeability in viro. However, there has been some uncertainty as to its suitability for use as an indicator of the permeation of water-soluble molecules across the intestinal wall because it seems to traverse the mucosa in much greater quantities than sugar molecules of equivalent Mr. 2. We have measured the permeation of polyethylene glycol-400 and lactulose from aqueous solution across pure lipid solvents in vitro. We found considerable transport of polyethylene glycol-400 across chloroform (1.03 g h−1 m−2) but no movement across petroleum ether. 3. However, in a separate experiment in which phospholipid (egg lecithin) was dissolved in the petroleum ether, permeation of polyethylene glycol-400 did occur (0.13 g h−1 m2), implying interaction of polyethylene glycol-400 with the phospholipid. No permeation of lactulose was seen in any of the experiments. 4. Our results suggest that, because of its interaction with lipid solvents, polyethylene glycol-400 is unsuitable as a probe to measure passive intestinal permeability in vivo.
43
Suhendar, Aang, Rukman Hertadi, and Yani F. Alli. "MOLECULAR DYNAMICS STUDY OF OLEIC ACID-BASED SURFACTANTS FOR ENHANCED OIL RECOVERY." Scientific Contributions Oil and Gas 41, no. 3 (2020): 125–35. http://dx.doi.org/10.29017/scog.41.3.331.
Pełny tekst źródłaStreszczenie:
Surfactants have been intensively used for Enhanced Oil Recovery (EOR). Nevertheless, environmental issues cause some surfactants to become unfavored in EOR application. Biodegradable surfactants are the suitable choice to make the environment safer. However, screening surfactants that have a good performance for EOR are time-consuming and costly. Molecular Dynamics (MD) simulation is an alternative solution to reduce cost and time. In the present study, oleic acid-based surfactants that combined with the various length of polyethylene glycol were studied. The potential surfactants were screened by MD simulation to evaluate their ability to reduce the Interfacial Tension (IFT) between oil and water layers, which is the by GROMACS software with Gromos force field and SPC water model. Carboxyl-terminal of the oleic acid was substituted by a different length of polyethylene glycol. All MD simulations were prepared in octadecanewater mixture with temperature ranges of 303-363 K. Our simulations found that the increasing number of polyethylene glycol was not always followed by the decreasing of IFT value between octadecane and water layers. These results were validated with the experimental data and found the similar IFT profile. The simulation of oil emulsification showed that all surfactant samples have good performance and stability as exhibited by their emulsification rate and emulsion stability in different temperatures. The last test to get the best surfactant was the wetability test. The simulation gave the result that both PEG100-oleic and PEG400-oleic were able to change wetability of rocks from oil-wet to water-wet. Accordingly, PEG400-oleic is the best nonionic surfactant candidate due to its performance in each simulation test.
44
Bayer, Ernst, Martin Maier, Konrad Bleicher, and Hans-Joachim Gaus. "Synthesis of 3′-PEG -Modified Oligonucleotides on PS -PEG Tentacle Polymers." Zeitschrift für Naturforschung B 50, no. 4 (1995): 671–76. http://dx.doi.org/10.1515/znb-1995-0433.
Pełny tekst źródłaStreszczenie:
PS-PEG tentacle polymers are modified for the synthesis of oligonucleotides covalently bound to polyethylene glycol (P E G ) at their 3′-position by the solid phase method without additional steps. The average stepwise coupling rates and overall yields are in the range of standard oligonucleotide synthesis. Oligonucleotides and phosphorothioates up to 20 nucleotides, modified with hexaethylene glycol (H E G ), PEG400 and PEG1500, are synthesized in this manner. The products are characterized by capillary electrophoresis and electrospray mass spectrometry (ES-MS). These new methods are very efficient for purity control as it is required for potential antisense drugs.
45
Auzanneau, France-Isabelle, Mette Knak Christensen, Shannon L. Harris, Morten Meldal, and B. Mario Pinto. "Synthesis and characterization of polyethylene glycol polyacrylamide copolymer (PEGA) resins containing carbohydrate ligands. Evaluation as supports for affinity chromatography." Canadian Journal of Chemistry 76, no. 8 (1998): 1109–18. http://dx.doi.org/10.1139/v98-118.
Pełny tekst źródłaStreszczenie:
The PEGA resin, a beaded polyethylene glycol dimethylacrylamide copolymer, was evaluated as an affinity support for the purification of carbohydrate-binding macromolecules, namely, the cation-independent mannosyl phosphate receptor (CI-MPR) and a polyclonal antibody directed against a Streptococcus Group A oligosaccharide. Two polyethylene glycol (PEG) derivatives, a di-acryloylated PEG1900derivative or a longer di-acryloylated PEG4000derivative, were used as cross-linkers. The longer cross-linker was synthesized in four steps from polyethylene glycol 4000. The mannosyl 6-phosphate (M6P)-containing immunoaffinity columns were prepared through the inverse suspension radical copolymerization of the corresponding allyl glycoside with acrylamide and the PEG cross-linker. The resin with the shorter cross-linker (PEG1900derivative) had a 6.3% molar cross-linking while that with the longer cross-linker (PEG4000derivative) had a 3.8% molar cross-linking. For the Streptococcus Group A trisaccharide-containing immunoaffinity columns, three PEGA affinity supports bearing free amino groups were prepared and subsequently substituted with a trisaccharide activated as its squarate adduct. While one resin contained the shorter cross-linker PEG1900and had a 3% molar cross-linking, the other two resins contained the longer cross-linker PEG4000 with a molar cross-linking of 5% and 3%, respectively. In affinity chromatographic studies, the M6P-containing columns were ineffective in retaining the cation-independent mannosyl phosphate receptor (CI-MPR, ~ 215kDa), whereas antibody (~ 150kDa) retention was observed with two of the three Streptococcus Group A trisaccharide-containing immunoaffinity columns. Key words: PEGA resins, immunoaffinity supports, carbohydrate ligands, antibody purification.
46
Karsakova, O. A., and M. V. Kuzmin. "Synthesis and research of photocurable protective coatings on the basis of olygoesteracrylates." Chimica Techno Acta 7, no. 4 (2020): 229–32. http://dx.doi.org/10.15826/chimtech.2020.7.4.16.
Pełny tekst źródłaStreszczenie:
In this work, photocurable protective coatings based on methacrylic acid esters have been developed and their physical and mechanical properties have been investigated. The photocurable compositions were obtained by mixing at different ratios the following methacrylic acid esters: polyethylene glycol dimethacrylate 400 and triethylene glycol dimethacrylate ether, polyethylene glycol dimethacrylate 400 and oligourethane dimethacrylate, polyethylene glycol dimethacrylate 400 and pentaerythritol tetraacrylate. For the obtained compositions, the viscosity was studied using a Brookfield rotary viscometer. To initiate polymerization, a mixture of initiators was used: benzoyl peroxide and benzoin. Curing of the obtained compositions was carried out under the influence of UV rays for 2-5 minutes. For photo-cured compositions, their physical and mechanical properties have been studied. It was found that the composition based on polyethylene glycol dimethacrylate modified with triethylene glycol dimethacrylate at a ratio of 70:30 has the highest strength.
47
Vaňura, Petr, and Pavel Selucký. "Extraction of polyethylene glycols with dicarbolide solutions in nitrobenzene." Collection of Czechoslovak Chemical Communications 55, no. 8 (1990): 1959–67. http://dx.doi.org/10.1135/cccc19901959.
Pełny tekst źródłaStreszczenie:
The extraction of polyethylene glycol of average molecular mass 400 (PEG 400) with dicarbolide solution in nitrobenzene and of longer-chain polyethylene glycol, of average molecular mass 1 500 (PEG 1 500), with chlorinated dicarbolide solution in nitrobenzene was studied. During the extraction of PEG 400, the polyethylene glycol solvates the Horg+ ion in the organic phase giving rise to the HLorg+ species (L is polyethylene glycol). The obtained value of the extraction constant Kex(HLorg+) = 933 is consistent with published data of metal extraction. Extraction of PEG 1 500 was treated applying the simplified assumption that the thermodynamic behaviour of PEG 1 500 is the same as that of n molecules of polyethylene glycol with relative molecular mass 1 500/n, each solvating one cation. For this model, the value of n = 3.2 ± 1.1 and the values of the extraction constants of the HL1/n,org+ and HL2/n,org+ species were obtained by using the adapted program LETAGROP. This value of n is consistent with published extraction data in the presence of polyethylene glycol with a relative molecular mass from 200 to 1 000.
48
B., Baloǧlu, and Kirkaǧaçhoǧlu O. "Preparation and evaluation of tolmetin sodium conventional and sustained-release suppositories." Scientia Pharmaceutica 70, no. 1 (2002): 77–86. http://dx.doi.org/10.3797/scipharm.aut-02-09.
Pełny tekst źródłaStreszczenie:
Conventional suppositories of tolmetin sodium were prepared by using two different types of Witepsol as an oily base and two different ratios of polyethylene glycol 400: polyethylene glycol 4000 as an water-soluble base. In addition, sustained- release suppositories were prepared by adding Eudragit L-100 ta the suppositories. The effects of the suppository base and the ratios of the polyethylene glycol 400: polyethylene glycols 4000 on the in vitro release characteristics were investigated. The release rate of tolmetin sodium from the conventional suppositories prepared with polyethylene glycol was slower than the other suppositories prepared with Witepsol. All of the suppositories with Eudragit L-100 showed slow-release profiles and the drug release rates clearly depended on the Eudragit L-100 content. When dissolution results were evaluated kinetically, zero order kinetic was observed with the sustained- release suppositories of tolmetin sodium prepared with polyethyleneglycol 400: polyethyleneglycol 4000 by adding Eudragit L-100.
49
Nalawade, TriveniMohan, SumaH P. Sogi, and Kishore Bhat. "Bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400, and polyethylene glycol 1000 against selected microorganisms." Journal of International Society of Preventive and Community Dentistry 5, no. 2 (2015): 114. http://dx.doi.org/10.4103/2231-0762.155736.
Pełny tekst źródła
50
Chobe, Santosh S., Nilesh J. Mali, Charushila K. Nerkar, Savita S. Chobe, Arvind M. Patil, and Trupti Tated. "Efficient Green Synthesis, Molecular Modeling and Antimicrobial Investigations of Novel Chloroflavone Libraries." Asian Journal of Organic & Medicinal Chemistry 6, no. 3 (2021): 161–66. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p330.
Pełny tekst źródłaStreszczenie:
In this article, a sequence of novel substituted 3-chloroflavones derivatives has been synthesized by using the inexperienced efficiency of solvent polyethylene glycol-400. This novelty of prepared derivatives was examined for their antifungal and their in silco docking study. Polyethylene glycol-400 is known as a green solvent to get to the bottom of the ecosystem’s toxic solvent load. A collection of novel substituted 3-chloroflavones derivatives has been synthesized by using the inexperienced functionality of polyethylene glycol-400 solvent. These newly prepared formulations had been evaluated for their antifungal and their in silico docking study. The structures of all the synthesized compounds were characterized with FT-IR, 1H NMR and HRMS techniques.