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Artykuły w czasopismach na temat „Polyvinylpyrollidin K90 (PVP K90)”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Muter, Sarah Sabah, and Athmar Dhahir Habeeb. "Preparation and evaluation of gastroretentive floating unfolding film of baclofen." Pharmacia 72 (May 14, 2025): 1–12. https://doi.org/10.3897/pharmacia.72.e147835.

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Baclofen, a muscle relaxant used for severe pain management, has a narrow absorption window limiting its bioavailability. Enhancing its gastric residence time could potentially improve its absorption and effectiveness. Floating drug delivery systems are a promising approach to prolong drug retention in the stomach. This study aimed to develop a floating bilayer film for the sustained release of baclofen. The core of the film was formulated with baclofen, PVP K90, sodium alginate, and PEG 400 as a plasticizer, while the controlled release layer contained Eudragit RS100 or RLPO with different pl

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2

Wu, Yong-Hui, Hai-Peng Li, Xin-Xin Shi, Jia Wan, Yi-Fan Liu, and Deng-Guang Yu. "Effective Utilization of the Electrostatic Repulsion for Improved Alignment of Electrospun Nanofibers." Journal of Nanomaterials 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/2067383.

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Uniaxial alignment of electrospun fibers can provide a useful approach to develop novel functional nanomaterials for applications in a wide variety of fields. In this study, a polypropylene- (PP-) coated spinneret and a metal spinneret were utilized to carry out the single-fluid electrospinning processes. A metal rod frame was utilized as the collector to steer the nanofibers. Using polyvinylpyrrolidone K90 (PVP K90) as a filament-forming polymeric model at a concentration of 9% (w/v) in ethanol, the experimental observations and results demonstrated the following results: (1) the utilization

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Suksaeree, Jirapornchai, Patsakorn Siripornpinyo, and Somruethai Chaiprasit. "Formulation, Characterization, and In Vitro Evaluation of Transdermal Patches for Inhibiting Crystallization of Mefenamic Acid." Journal of Drug Delivery 2017 (November 12, 2017): 1–7. http://dx.doi.org/10.1155/2017/7358042.

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The crystallization of mefenamic acid in transdermal patch is a major problem that makes the patch unstable and decreases the drug release. The additive was used to inhibit crystallization of a mefenamic acid. Among the different types of additives, polyvinylpyrrolidone (PVP) K30 and PVP K90 were studied and found to be highly effective in inhibiting the crystallization of the drug. The PVP presented as a solubilizer agent for mefenamic acid in matrix patches at the different ratio between drug : PVP, 1 : 2 and 1 : 2.5 for using PVP K30 and 1 : 1.5 and 1 : 2 for using PVP K90. The characteriza

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Gönüllü, Ü., P. Gürpınar, and M. Üner. "Double-layer Tablets of Lornoxicam: Validation of Quantification Method, In vitro Dissolution and Kinetic Modelling." Tropical Journal of Pharmaceutical Research 14, no. 9 (2015): 1659–66. http://dx.doi.org/10.4314/tjpr.v14i9.16.

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Purpose: To formulate double-layer tablets of lornoxicam (LRX) prepared by direct compression method and evaluate their physical and drug release characteristics.Methods: The outer layer of tablets, composed of microcrystalline cellulose (MCC), starch and lactose, incorporated tan initial or prompt dose of the drug (4 mg) for immediate release. Hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP K90) and carbomer, in varying concentrations, were used to prepare the tablet cores for sustained drug delivery. Weight variation, dimensions, hardness, tensile strength, friability and dis

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5

Chaiwarit, Tanpong, Baramee Chanabodeechalermrung, Pensak Jantrawut, Warintorn Ruksiriwanich, and Mathukorn Sainakham. "Fabrication and Characterization of Dissolving Microneedles Containing Oryza sativa L. Extract Complex for Enhancement of Transfollicular Delivery." Polymers 16, no. 16 (2024): 2377. http://dx.doi.org/10.3390/polym16162377.

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Dissolving microneedles are extensively applied in drug delivery systems to enhance penetration into the skin. In this study, dissolving microneedles fabricated from polyvinylpyrrolidone K90 (PVP-K90) and hydroxypropylmethyl cellulose (HPMC) E50 in different ratios were characterized. The selected formulations incorporated Oryza sativa L. extract complex and its characteristics, transfollicular penetration, and safety were observed. The microneedles, fabricated from PVP K90: HPMC E50 in a ratio of 25:5 (P25H5) and 20:10 (P20H10), revealed excellent morphological structure, proper mechanical st

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6

Patomchaiviwat, Vipaluk, Suchada Piriyaprasarth, Bunyarit Chaisomboonphan, Chitatharinth Limpoemwuttiporn, and Pornsuda Nuamnoi. "Modification of Starch Extracted from Black Glutinous Rice (Oryza sativa L, Variety Leum Pua) as Tablet Filler." Advanced Materials Research 1060 (December 2014): 58–61. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.58.

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The aim of this study was to investigate the modification of black glutinous rice starch (BGRS) as tablet filler. The black glutinous rice was treated with NaCl and NaOH to obtain BGRS. The native BGRS was modified by pregelatinizaion and prepared as co-composite and used as filler in tablet formulation compared with Starch 1500®. Propranolol was used as a model drug. The properties of tablets including disintegration time were evaluated. Interestingly, the disintegration times of the native BGRS was less than 90s which was faster than Starch 1500®. The results suggest that the native BGRS wou

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7

Perumalla, Ashok Kumar 1. *. Dr. Deenanath Jhade 2. "FORMULATION AND INVITRO EVALUATION OF RIZATRIPTAN ORAL THIN FILMS." Journal of Scientific Research in Pharmacy 7, no. 7 (2018): 74–78. https://doi.org/10.5281/zenodo.1318318.

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<strong><em>ABSTRACT</em></strong> <strong><em>I</em></strong><em>n present study oral thin films of Rizatriptan was developed to have a faster on set of action. The oral thin films were developed by using polymers HPMC E5, HPMC E 15 and PVP K90.Oral thin films were prepared by employing solvent casting method. Propylene glycol was selected as permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and al

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8

Wan, Lucy S. C., Paul W. S. Heng, and B. L. Ling. "Fluidized Bed Granulation with Pvp K90 and Pvp K120." Drug Development and Industrial Pharmacy 21, no. 7 (1995): 857–62. http://dx.doi.org/10.3109/03639049509026650.

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9

Zhu, Jie-Jun, Cai-Xia Kan, Jian-Guo Wan, Min Han, and Guang-Hou Wang. "High-Yield Synthesis of Uniform Ag Nanowires with High Aspect Ratios by Introducing the Long-Chain PVP in an Improved Polyol Process." Journal of Nanomaterials 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/982547.

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Polyvinyl pyrrolidone (PVP) with different molecular weights was used as capping agent to synthesize silver nanowires through a polyol process. The results indicated that the yields and aspect ratios of silver nanowires were controlled by the chain length of PVP and increased with increasing the molecular weight (MW) of PVP. When the long-chain PVP-K90 (MW = 800,000) was used, the product was uniform in size and was dominated by nanowires with high aspect ratios. The growth mechanism of the nanowires was studied. It is proposed that the chemical adsorption of Ag+on the PVP chains at the initia

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10

Preedalikit, Weeraya, Chuda Chittasupho, Pimporn Leelapornpisid, Sheng Qi, and Kanokwan Kiattisin. "Development and Evaluation of Anti-Pollution Film-Forming Facial Spray Containing Coffee Cherry Pulp Extract." Pharmaceutics 17, no. 3 (2025): 360. https://doi.org/10.3390/pharmaceutics17030360.

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Background/Objectives: This study aimed to develop and evaluate an anti-pollution film-forming spray (FFS) containing coffee cherry pulp extract (FFS-CCS). The formulation was designed to create a protective skin barrier, improving skin health while defending against environmental pollutants. Its physical properties, dust resistance, stability, skin penetration, and clinical effectiveness were assessed to ensure optimal performance and safety. Methods: Various polymers and a ternary solvent system were used to enhance the stability and solubility of bioactive compounds from the coffee cherry p

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11

Li, Ding, Menglong Wang, Wen-Liang Song, Deng-Guang Yu, and Sim Wan Annie Bligh. "Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs." Biomolecules 11, no. 5 (2021): 635. http://dx.doi.org/10.3390/biom11050635.

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A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-o

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12

Ibrahim, Mohamed Abbas, and Doaa Hasan Alshora. "Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization." Polymers 13, no. 22 (2021): 4034. http://dx.doi.org/10.3390/polym13224034.

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Aceclofenac (AC) is a nonsteroidal anti-inflammatory drug used in the treatment of chronic pain in conditions such as rheumatoid arthritis, with frequent administration during the day. The formulation of sustained release matrix pellets can provide a promising alternative dosage form that controls the release of the drug, with less blood fluctuation and side effects—especially those related to the gastric system. The extrusion/spheronization technique was used to formulate AC matrix pellets. The response surface methodology (version 17.2.02.; Statgraphics Centurion) was used to study the impac

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13

Laosirisathian, Nachtharinee, Chalermpong Saenjum, Jakkapan Sirithunyalug, Sukum Eitssayeam, Wantida Chaiyana, and Busaban Sirithunyalug. "PVA/PVP K90 Nanofibers Containing Punica granatum Peel Extract for Cosmeceutical Purposes." Fibers and Polymers 22, no. 1 (2021): 36–48. http://dx.doi.org/10.1007/s12221-021-0165-0.

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14

Suhaidi, Danni, Yao-Da Dong, Paul Wynne, Karen P. Hapgood, and David A. V. Morton. "Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification." Pharmaceutics 15, no. 5 (2023): 1447. http://dx.doi.org/10.3390/pharmaceutics15051447.

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Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability. However, the inherent nature of spray-dried ASDs leads to their surface cohesion/adhesion, including hygroscopicity, which hinders their bulk flow and affects their utility and viability in terms of powder production, processing, and function. This study explores the effectiveness of L-leucine (L-leu) coprocessing in modifying the particle surface of ASD-forming materials. Various contrasting

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15

Qin, Jian-Jun, Fook-Sin Wong, Ying Li, and Yu-Tie Liu. "A high flux ultrafiltration membrane spun from PSU/PVP (K90)/DMF/1,2-propanediol." Journal of Membrane Science 211, no. 1 (2003): 139–47. http://dx.doi.org/10.1016/s0376-7388(02)00415-5.

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16

Chanabodeechalermrung, Baramee, Tanpong Chaiwarit, Siripat Chaichit, et al. "HPMC/PVP K90 Dissolving Microneedles Fabricated from 3D-Printed Master Molds: Impact on Microneedle Morphology, Mechanical Strength, and Topical Dissolving Property." Polymers 16, no. 4 (2024): 452. http://dx.doi.org/10.3390/polym16040452.

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Three-dimensional (3D) printing can be used to fabricate custom microneedle (MN) patches instead of the conventional method. In this work, 3D-printed MN patches were utilized to fabricate a MN mold, and the mold was used to prepare dissolving MNs for topical lidocaine HCl (L) delivery through the skin. Topical creams usually take 1–2 h to induce an anesthetic effect, so the delivery of lidocaine HCl from dissolving MNs can allow for a therapeutic effect to be reached faster than with a topical cream. The dissolving-MN-patch-incorporated lidocaine HCl was constructed from hydroxypropyl methylce

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17

Tian, Li Qiang, and Pei Pei Zhang. "Self-Assembled Core-Shell Fe₃O₄@SiO₂Nanoparticles with High Magnetic Sensitivity from Electrospun Fibers." Advanced Materials Research 1033-1034 (October 2014): 1068–71. http://dx.doi.org/10.4028/www.scientific.net/amr.1033-1034.1068.

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Nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K90 (PVP), cetyltrimethylammonium bromide (CTAB), tetraethyl orthosilicate (TEOS) and Fe3O4were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanfibers, silica coated magnetite (Fe3O4@SiO2) core-shell nanoparticles (NPs) with high magnetic sensitivity were spontaneously formed through molecular self-assembly when the fibers were added to 80% aqueous ethanol (PH=9.0). The typical saturation magnetization of the Fe3O4@SiO2composite particles is up to 43.8 emu/g, with

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18

Du, Yutong, Zili Yang, Shixiong Kang, Deng-Guang Yu, Xiren Chen, and Jun Shao. "A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose." Sensors 23, no. 7 (2023): 3685. http://dx.doi.org/10.3390/s23073685.

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This study presents a glucose biosensor based on electrospun core–sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely of core–sheath nanofibers fabricated using a modified coaxial electrospinning process. Film F2 was a double-layer hybrid film fabricated through a sequential electrospinning and blending process. The bottom layer of F2 comprised core–sheath nanofibers fabricated using a modified process, in which pure polymethacrylate type A (Eudragit L100) was used as the core section and water-soluble lignin (WSL) and ph

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19

Chen, Chun Hua, Jia Jia Feng, Wei Quan Shao, et al. "Electrochemical Performance of Li₄Ti₅O₁₂/TiO₂/Li_0.4TiO₂/C Composite Prepared by the Electrospinning Method Using as Lithium Battery Anode Material." Materials Science Forum 852 (April 2016): 959–62. http://dx.doi.org/10.4028/www.scientific.net/msf.852.959.

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Li4Ti5O12(LTO) and Li4Ti5O12/TiO2/Li0.4TiO2/C (LTO/C) composite were prepared by the electrospinning method using acetic acid, ethanol, butyl titanate, lithium acetate and PVP (K90) as the raw materials. The phase structure and the morphology were characterized by the X-ray diffraction (XRD) and the scanning electron microscopy (SEM), respectively. It was found that the specific capacity was 356mAh/g at 0.5C for the composite, which was higher than the theoretical specific capacity of the pure Li4Ti5O12 due to the inclusion of other phase. Moreover, the C-rate performance for the composite was

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20

Muter, Sarah Sabah, and Athmar Dhahir Habeeb. "Preparation and evaluation of gastroretentive floating unfolding film of baclofen." Pharmacia 72 (May 14, 2025): 1–12. https://doi.org/10.3897/pharmacia.72.e147835.

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Baclofen, a muscle relaxant used for severe pain management, has a narrow absorption window limiting its bioavailability. Enhancing its gastric residence time could potentially improve its absorption and effectiveness. Floating drug delivery systems are a promising approach to prolong drug retention in the stomach. This study aimed to develop a floating bilayer film for the sustained release of baclofen. The core of the film was formulated with baclofen, PVP K90, sodium alginate, and PEG 400 as a plasticizer, while the controlled release layer contained Eudragit RS100 or RLPO with different pl

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Albertini, Beatrice, Cristina Cavallari, Nadia Passerini, M. L. González-Rodrı́guez та Lorenzo Rodriguez. "Evaluation of β-lactose, PVP K12 and PVP K90 as excipients to prepare piroxicam granules using two wet granulation techniques". European Journal of Pharmaceutics and Biopharmaceutics 56, № 3 (2003): 479–87. http://dx.doi.org/10.1016/s0939-6411(03)00114-0.

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Esmaielzadeh Kandjani, A., Mohammad Reza Vaezi, Ali Shokuhfar, and M. Farzalipour Tabriz. "Investigation of Reaction Conditions on Alcohol-Thermal Synthesis of ZnO Nanoparticles." Defect and Diffusion Forum 273-276 (February 2008): 198–203. http://dx.doi.org/10.4028/www.scientific.net/ddf.273-276.198.

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ZnO nanoparticles because of their interesting properties and various morphologies, has become one of the most attractive nanomaterials for research objectives. Its significant properties has made it applicable in UV-Light emitters, varistors, transparent high power electronics, gas sensors, etc., [1]. Many approaches have been used to obtain ZnO nanoparticles, including: Hydrothermal [2], Solvothermal [3], Reverse micelles [4], Sol-Gel [4], Sonochemical [5], and Chemical Bath Deposition [6], etc. Among these, hydrothermal and alcohol-thermal methods have been extremely investigated. In this p

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23

Taokaew, Siriporn, Saowalak Phonsee, Nisanart Woravut, Tasana Pitaksutepong, and Worawut Kriangkrai. "Characteristic Assessment of the Polymeric Films Used for Hair Gel Products in Thailand." Key Engineering Materials 819 (August 2019): 98–103. http://dx.doi.org/10.4028/www.scientific.net/kem.819.98.

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The market of hair gel products in Thailand steadily grows with the changing trend of fashion every year. The main component of the hair gel products is the fixative polymer, which plays a role in hair styling properties including stiffness and curl retention. Properties of the hair styling product depending on hair types and climates must be suitably improved for Thai hair. In this study, 10 %w/w gel solutions of polyacrylic acid, polyquaternium-86, polyvinylpyrrolidone (PVP), acrylates copolymer, and vinylpyrrolidone (VP) copolymers were cast as polymeric thin films. The film properties such

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24

Adeli, Ehsan. "Irbesartan-loaded electrospun nanofibers-based PVP K90 for the drug dissolution improvement: Fabrication,in vitroperformance assessment, andin vivoevaluation." Journal of Applied Polymer Science 132, no. 27 (2015): n/a. http://dx.doi.org/10.1002/app.42212.

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Shaikh, Amir A., Praveen D. Chaudhari, and Sagar S. Holkar. "A DESIGN OF EXPERIMENT APPROACH FOR OPTIMIZATION AND CHARACTERIZATION OF ETODOLAC TERNARY SYSTEM USING SPRAY DRYING." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 2 (2017): 233. http://dx.doi.org/10.22159/ijpps.2017v9i2.16087.

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<p><strong>Objective: </strong>The objective of the present investigation was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system in order to study the effect of complexation on solubility of ETO.</p><p><strong>Methods: </strong>Physical mixtures of a drug and polymers in different weight ratios (1:1, 1:2, 1:4) were prepared to study the effect of individual polymers on solubility of ETO. Spray drying method was used to investigate the combined effect of PVP K30 and HPB o

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Mahmood, Asia Abed Al, and Shaimaa N. Abd Alhammid. "Preparation and Ex-Vivo Evaluation of Stabilized Cefdinir Nanosuspension." Pakistan Journal of Medical and Health Sciences 16, no. 12 (2022): 789–94. http://dx.doi.org/10.53350/pjmhs20221612789.

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Purpose: The objective of this research is to prepare cefdinir as a nanosuspension formulation to improve its solubility and dissolution rate. Cefdinir is a class IV drug with low solubility and low permeability. Methods: Eight formulations were prepared with different types of stabilizers and different concentrations including poly vinyl pyrrolidone (PVP-K90), poly vinyl alcohol (PVA), D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) and soluplus ®. Ratio of drug to stabilizer used to prepare the nanosuspension were 1:1 and 1:2. The prepared nanosuspension formulations were evaluated

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Alotaibi, Badriyah Shadid, Muhammad Ahsan Khan, Kaleem Ullah, et al. "Formulation and characterization of glipizide solid dosage form with enhanced solubility." PLOS ONE 19, no. 2 (2024): e0297467. http://dx.doi.org/10.1371/journal.pone.0297467.

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Glipizide, a poor water-soluble drug belongs to BCS class II. The proposed work aimed to enhance the solubility of glipizide by preparing solid dispersions, using polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG). Solvent evaporation method was used for the preparation of glipizide solid dispersions. Solid dispersions were prepared in four different drug-to-polymer ratios i.e. 1:1, 1:2, 1:3 and 1:4. Mainly effect of three polymers (PVP K30, PVP K90 and PEG 6000) was evaluated on the solubility and dissolution of glipizide. The in-vitro dissolution of all prepared formulations was perfo

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Ponnusamy, Chandrasekar, Abimanyu Sugumaran, Venkateshwaran Krishnaswami, Rajaguru Palanichamy, Ravichandiran Velayutham, and Subramanian Natesan. "Development and Evaluation of Polyvinylpyrrolidone K90 and Poloxamer 407 Self-Assembled Nanomicelles: Enhanced Topical Ocular Delivery of Artemisinin." Polymers 13, no. 18 (2021): 3038. http://dx.doi.org/10.3390/polym13183038.

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Age-related macular degeneration is a multifactorial disease affecting the posterior segment of the eye and is characterized by aberrant nascent blood vessels that leak blood and fluid. It ends with vision loss. In the present study, artemisinin which is poorly water-soluble and has potent anti-angiogenic and anti-inflammatory properties was formulated into nanomicelles and characterized for its ocular application and anti-angiogenic activity using a CAM assay. Artemisinin-loaded nanomicelles were prepared by varying the concentrations of PVP k90 and poloxamer 407 at different ratios and showe

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Bhardi, Shashank S., Vidhyashree B, Arvinder Kaur, and Preethi G B. "Development and Evaluation of Polymeric Film Forming Solution of Ciclopirox Olamine for Topical Fungal Therapy." Journal of Advances in Medical and Pharmaceutical Sciences 27, no. 5 (2025): 65–77. https://doi.org/10.9734/jamps/2025/v27i5778.

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Aim: Formulation and assessment of polymeric film forming solution (PFFS) loaded with Ciclopirox olamine (CPO) for managing topical fungal infections. Methods: PFFS was prepared using a common solvent method with a range of polymers, such as Eudragit RL 100, Eudragit RS 100, PVP K30, PVP K90, HPC, HPMC K15, HPMC K4M, and PEG 400 in ethanol. The formulated PFFS was evaluated for Physicochemical properties, In vitro drug release, ex vivo permeation studies, stability studies, and antifungal assay. Results: The formulations have exhibited drying time of less than one minute. Most of them demonstr

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Amal Abdullah Mohammed and Shaimaa Nazar Abd Alhammid. "Preparation, In Vitro Evaluation and Characterization studies of Clozapine Nanosuspension." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 336–48. https://doi.org/10.31351/vol33iss(4si)pp336-348.

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Clozapine (CLZ) is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It belongs to the Biopharmaceutical Classification System (BCS) class II drug (High Permeability, Low Solubility), with a high first-pass effect. The current study used a technique called the solvent-antisolvent method to prepare a nanosuspension of clozapine with different stabilizers and solvents in an effort to increase the drug's solubility and dissolution. (Soluplus®, HPMC E15, PVA, Poloxamer 188, Poloxamer 407, PVP K30, PVP K90, and Tween 40) were used to produce the formula. Evaluations were

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Zhou, Xuebing, Qian Zhang, Zhen Long, and Deqing Liang. "In situ PXRD analysis on the kinetic effect of PVP-K90 and PVCap on methane hydrate dissociation below ice point." Fuel 286 (February 2021): 119491. http://dx.doi.org/10.1016/j.fuel.2020.119491.

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Alhagiesa, Areej Wahhab, and Mowafaq M. Ghareeb. "Formulation and Characterization of Nimodipine Nanoparticles for the Enhancement of solubility and dissolution rate." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 2 (2021): 143–52. http://dx.doi.org/10.31351/vol30iss2pp143-152.

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Nimodipine (NMD) is a dihydropyridine calcium channel blocker useful for the prevention and treatment of delayed ischemic effects. It belongs to class ? drugs, which is characterized by low solubility and high permeability. This research aimed to prepare Nimodipine nanoparticles (NMD NPs) for the enhancement of solubility and dissolution rate. The formulation of nanoparticles was done by the solvent anti-solvent technique using either magnetic stirrer or bath sonicator for maintaining the motion of the antisolvent phase. Five different stabilizers were used to prepare NMD NPs( TPGS, Soluplus®,

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Boontha, Supavadee, Jirapon Taowkaen, Thanaporn Phakwan, et al. "Evaluation of antioxidant and anticancer effects of Piper betle L (Piperaceae) leaf extract on MCF-7 cells, and preparation of transdermal patches of the extract." Tropical Journal of Pharmaceutical Research 18, no. 6 (2021): 1265–72. http://dx.doi.org/10.4314/tjpr.v18i6.17.

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Purpose: To determine the antioxidant and anticancer effects of Piper betle (P. betle) leaf extract on human breast cancer MCF-7 cells, and to develop transdermal patches containing the extract. Methods: The leaf extract of P. betle was prepared by maceration method, and its antioxidant activity was evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Cytotoxicity and suppression of cell migration (indices of anticancer activity) were also assessed in MCF-7 cells by sulforhodamine B (SRB) and wound healing assays, respectively. Transdermal patches were develope

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Prabahar, Kousalya, Ubaidulla Uthumansha, Nehal Elsherbiny та Mona Qushawy. "Enhanced Skin Permeation and Controlled Release of β-Sitosterol Using Cubosomes Encrusted with Dissolving Microneedles for the Management of Alopecia". Pharmaceuticals 16, № 4 (2023): 563. http://dx.doi.org/10.3390/ph16040563.

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The use of synthetic medication for treating alopecia is restricted because of systemic exposure and related negative effects. Beta-sitosterol (β-ST), a natural chemical, has lately been studied for its potential to promote hair development. The cubosomes with dissolving microneedles (CUBs-MND) created in this study may be a useful starting point for the creation of a sophisticated dermal delivery system for β-ST. Cubosomes (CUBs) were prepared by the emulsification method, using glyceryl monooleate (GMO) as a lipid polymer. CUBs were loaded with dissolving microneedles (MND) fabricated with H

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O., Kumar* A. Prameela Rani and V. Saikishore. "PREPARATION AND CHARATEIZATION OF OLMESARTAN MEDOXOMIL SOLID DISPERSION FOR THE DEVELOPMENT OF ORODISPERSABLE TABLETS." iajps,csk publications 03, no. 11 (2016): 1330–36. https://doi.org/10.5281/zenodo.192352.

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<em>Solid dispersions were prepared by solvent evaporation method with different</em> <em>carriers such as PVP-K90, mannitol and urea in different proportions.</em><em> All the solid dispersions prepared were evaluated for saturation solubility study, drug content and for dissolution studies. Among all the formulations prepared, solid dispersions prepared with Olmesartan medoxomil and Urea in 1:3 ratio showed highest drug release in 60 minutes. To study the influence of superdisintegrants on the performance of Olmesartan Medoxomil Orodispersible Tablets, a set of three formulations (F<sub>10</

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Nabil Abdullah та Amit B Patil. "Application of DoE in polymers screening and optimization of in situ topical ϑilm-forming solution for spray formulation". International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2499–515. http://dx.doi.org/10.26452/ijrps.v11ispl4.4505.

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DoE is a structured and organised method to determine the relationship between the effect of change in the concentration of the independent variables and its impact on the formulation, through establishing a mathematical model. Since the acceptance of the QbD approach by the regulatory authorities across the world, DoE has been widely implemented in the areas of screening and optimisation of the formulations by the pharmaceutical industries. The topical delivery of API still posses' limitations such as insufficient contact time, odd hours of application time, sticking to fabrics, formulation w

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Dawood, Noor Mohammed, Shaimaa Nazar Abdal-hammid, and Ahmed Abbas Hussien. "FORMULATION AND CHARACTERIZATION OF LAFUTIDINE NANOSUSPENSION FOR ORAL DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 2 (2018): 20. http://dx.doi.org/10.22159/ijap.2018v10i2.23075.

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Objective: The objective of this study was to prepare nanosuspension of a practical water insoluble antiulcer drug which is lafutidine to enhance the solubility, dissolution rate with studying the effect of different formulation variables to obtain the best formula with appropriate physical properties and higher dissolution rate.Methods: Nanosuspension of lafutidine was prepared using solvent anti-solvent precipitation method using Polyvinylpyrrolidone K-90(PVP K-90) as the stabilizer. Ten formulations were prepared to show the effect of different variables in which two formulations showed the

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Wattanaphraya, Nattanich, Somkamol Manchun, Siriporn Taokaew, and Worawut Kriangkrai. "Development of Mucoadhesive Film-Forming Systems Containing Black Ginger Extract for Aphthous Ulcers." Key Engineering Materials 901 (October 8, 2021): 104–10. http://dx.doi.org/10.4028/www.scientific.net/kem.901.104.

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Film-forming systems (FFSs) were developed by using Eudragit® E100 as a film former. Kaempferia parviflora (black ginger) extract was used as an anti-inflammatory agent for aphthous ulcers. The FFS could rapidly form a thin film in only 5 s when it was applied to a wet surface e.g. an aphthous ulcer. When the FFS was applied to a dry surface, the FFS without extract could form a film in 2-4 min. The incorporation of this extract contributed to delaying the film-formation time in the dry state; hence, the film-forming time increased to 6-8 min. The mucoadhesive property of FFSs was verified wit

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Nanda, Arun. "PREPARATION, CHARACTERIZATION AND DISSOLUTION OF SOLVENT EVAPORATED SIMVASTATIN SOLID DISPERSIONS." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 2813–28. http://dx.doi.org/10.22270/jmpas.v10i3.1179.

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Simvastatin an antihyperlipidemic BCS class II drug, suffering from poor water solubility. This problem may affect the bioavailability as well as pharmacological action of the drug. To overcome this solubility issue, solid dispersions of simvastatin were prepared and compared with marketed formulation “SIMVOTIN 20” in this study. Solid dispersions of simvastatin were prepared by using the solvent evaporation method. Solid dispersions of simvastatin with PVP K90 (1:1-1:5), HPMC E50 (1:1-1:5), and Poloxamer 450 (1:1 to 1:3) with and without 1% Sodium lauryl sulfate were prepared by a solvent eva

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Lê, Minh Quân, Lưu Việt Quý Đặng, Thị Anh Thư Nguyễn, Công Phi Nguyễn та Quan Nghiệm Lê. "ẢNH HƯỞNG CỦA THÀNH PHẦN CÔNG THỨC TRÊN TÍNH CHẤT HẠT VÀ VIÊN NÉN CHỨA MELOXICAM HÀM LƯỢNG THẤP ĐIỀU CHẾ BẰNG KỸ THUẬT TẠO HẠT TẦNG SÔI". Ho Chi Minh City Journal of Medicine - Pharmacy 27, № 1 (2024): 20–28. http://dx.doi.org/10.32895/hcjm.p.2024.01.03.

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Đặt vấn đề: Tạo hạt tầng sôi được áp dụng rộng rãi trong sản xuất dược phẩm. Nghiên cứu nhằm làm rõ ảnh hưởng của công thức trên tính chất và sự phân tán dược chất trong hạt và viên chứa dược chất hàm lượng thấp. Đối tượng và phương pháp nghiên cứu: Meloxicam là dược chất mô hình. Thiết kế thực nghiệm để xác định ảnh hưởng của loại tá dược độn; loại, tỷ lệ, cách thức phối tá dược dính trên lưu tính, tính chịu nén, tỷ số hạt/bột và độ đồng đều meloxicam trong hạt và viên. Kết quả: Bốn yếu tố công thức ảnh hưởng riêng phần đến lưu tính hạt và phân bố meloxicam, ảnh hưởng đồng thời trên tỷ số hạ

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Intharit, Ninnart, Arunporn Itharat, Chadchom Choockong, et al. "Development and evaluation of Sahasthara Thai medicine remedy in a film-forming spray for topical anti-inflammatory therapy." Research in Pharmaceutical Sciences 20, no. 1 (2025): 25–40. https://doi.org/10.4103/rps.rps_22_24.

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Background and purpose: The study aimed to develop a localized topical anti-inflammatory treatment using a Thai medicinal herbal remedy called "Sahasthara," known for its anti-inflammatory properties, to create a film-forming spray (FFS). Experimental approach: This research evaluated and developed an FFS formulated with Sahasthara ethanolic extract (SHTe). Subsequently, the optimized formulation was investigated for in vitro anti-inflammatory activity, cell culture toxicity assessment, pharmacological effects, and stability studies. Findings/Results: An optimized formulation (F12) was identif

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Murgia, Denise, Giuseppe Angellotti, Fabio D’Agostino, and Viviana De Caro. "Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization." Polymers 11, no. 11 (2019): 1801. http://dx.doi.org/10.3390/polym11111801.

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Periodontitis treatment is usually focused on the reduction or eradication of periodontal pathogens using antibiotics against anaerobic bacteria, such as metronidazole (MTR). Moreover, recently the correlation between periodontal diseases and overexpression of reactive oxygen species (ROS) led to the introduction of antioxidant biomolecules in therapy. In this work, bioadhesive buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and lipophilic nanoparticles as a vehicle of curcumin, were developed. Curcumin (CUR)-loaded nanostructured lipid carriers (NLC) were prepared

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Wang, Yanan, Chai-Yee Chin, Naveen Kumar Hawala Shivashekaregowda, and Qin Shi. "Effects of polyvinylpyrrolidone on the crystallization of amorphous griseofulvin: fracture and molecular mobility." Journal of Applied Crystallography 57, no. 3 (2024). http://dx.doi.org/10.1107/s1600576724003844.

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This study aims to investigate the fracture, molecular mobility and crystallization behaviors of amorphous griseofulvin (GSF) in the presence of polyvinylpyrrolidone (PVP). In the presence of 10%(w/w) PVP K90, the fracture resistance of griseofulvin was greatly improved. Compared with the pure GSF system, the average fracture temperature of the griseofulvin–PVP K90 system was decreased to approximately −6.1°C. More importantly, a statistical study revealed that the direct connection between fracture and nucleation of griseofulvin was weakened in the presence of PVP K90. This study also explore

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Chanabodeechalermrung, Baramee, Tanpong Chaiwarit, Suruk Udomsom, Pornchai Rachtanapun, Promporn Piboon, and Pensak Jantrawut. "Determination of vat-photopolymerization parameters for microneedles fabrication and characterization of HPMC/PVP K90 dissolving microneedles utilizing 3D-printed mold." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-67243-y.

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AbstractThree-dimensional (3D) printing serves as an alternative method for fabricating microneedle (MN) patches with a high object resolution. In this investigation, four distinct needle shapes: pyramid mounted over a long cube (shape A), cone mounted over a cylinder (shape B), pyramidal shape (shape C), and conical shape (shape D) were designed using computer-aided design (CAD) software with compensated bases of 350, 450 and 550 µm. Polylactic acid (PLA) biophotopolymer resin from eSun and stereolithography (SLA) 3D printer from Anycubic technology were used to print MN patches. The 3D-print

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Kikawoos, Haider H., and Athmar DH H. Al-Shohani. "Preparation and evaluation of biodegradable double-layer insert of Sulfacetamide sodium for ocular drug delivery." Palestinian Medical and Pharmaceutical Journal 10, no. 4 (2025). https://doi.org/10.59049/2790-0231.10.4.2411.

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A key challenge in ocular medication administration is attaining a therapeutic drug concentration at the site of action for a prolonged duration. The present study employed the antibacterial Sulfacetamide in a biodegradable ocular insert to achieve prolonged drug release. The inserts were prepared using solvent casting for the matrix and dipping technique for the rate-controlling layer. The polymers utilized were medium-viscosity sodium alginate, polyvinyl pyrrolidine K90, and Eudragit RLPO. All developed inserts were assessed for folding durability, thickness, drug content, swelling capacity,

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Tarawneh, Ola, Sara Almasri, Ala Abdulkareem Alhusban, et al. "Innovative Dissolving Microneedles for Enhanced Delivery of Alpha Arbutin and Ascorbic Acid: A Novel LC-MS Quantification Approach." Materials Advances, 2025. https://doi.org/10.1039/d4ma00908h.

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This study presents a novel dissolving microneedles (MNs) formulation designed to deliver alpha arbutin (AA) and ascorbic acid for hyperpigmentation treatment. Utilizing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP-K90), we successfully...

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Shete, Rahul, Bhaskar Thorat, and Purnima Amin. "The impacts of method selectivity and binders on the properties of carbamazepine granules and their applications: A case study." Pharmaceutical Sciences, November 26, 2021. http://dx.doi.org/10.34172/ps.2021.73.

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Background: Carbamazepine (CBZ) is a BCS II class drug, having many challenges in solubility, flowability, and compactibility. The study focused on the improvement of solubility, flow behavior, and drug release of carbamazepine. Methods: Low shear granulation (LSG), extrusion spheronization (ES), high shear granulation (HSG), fluid bed granulation (FBG), and hot melt granulation (HMG) methods were employed to prepare CBZ granules. Polyvinylpyrrolidone (PVP) K29/32, PVP K90, and Hydroxypropyl methylcellulose (HPMC) E5 were used as a binder. The drug to binder ratio was maintained in the proport

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Furqan, M. Abdulelah, and R. Abdulbaqi Mustafa. "Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam." August 18, 2021. https://doi.org/10.5281/zenodo.5218600.

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<strong>Objective:</strong> This research targeted to prepare, characterize and evaluate fast dissolving film nanocrystals (FDFN) of tenoxicam (TNX) as an innovative system using three different film-former polymers, HPMC E 30, PVP K90 and PVA, for the optimization of BCS class II drug solubility, dissolution rate and bioavailability.<strong> Methods: </strong>TNX nanocrystals first prepared using acid-base nanoprecipitation method, which further formulated into fifteen FDF using HPMC E 30, PVP K90 and PVA as film-formers. Films were then evaluated for appearance, surface pH, folding endurance

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Xing, Banghuai, Qian Luo, Tiantian Gan, et al. "Resveratrol-Loaded Dissolving Microneedles: Fabrication and in vitro Evaluation." Pharmaceutical Fronts, November 8, 2024. http://dx.doi.org/10.1055/s-0044-1791832.

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AbstractResveratrol (Res), an active ingredient derived from a multitude of plants, exhibits multiple pharmacological activities. However, its poor water solubility and low bioavailability present significant challenges to its clinical application. Our study aimed to improve the transdermal absorption of Res using dissolving microneedle (MN) technology, which could effectively overcome the stratum corneum barrier. Res-loaded dissolving microneedles (Res-MNs) were fabricated using polyvinyl pyrrolidone K90 (PVP K90) as the matrix material, and a two-step casting procedure was employed. The proc

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Farooq, Adil, and Ömer Necati Cora. "Fabrication and optimization of PES/PVP hollow fiber membranes using Box–Behnken model and CART algorithm." Journal of Applied Polymer Science, January 18, 2024. http://dx.doi.org/10.1002/app.55131.

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AbstractThis study focuses on the optimization of polyethersulfone (PES) hollow fiber membranes fabricated with the phase inversion method. A Box–Behnken experimental design was employed with three different PES concentration ratios (11, 14, 17 wt.%), three polyvinylpyrrolidone (PVP) molecular weight ratios (K30/K90 ratios of 6:0, 3:3, 0:6 wt.%), three different bore fluid (BF) composition ratios (water/alcohol ratios of 20:80, 60:40, 100:0), and three different air gap values (24, 37, and 50 cm). The results were analyzed in terms of pure water permeability (PWP) and porosity as optimization

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