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1

Neill, Colin Gardner. "Synthesis of pyridothiadiazine dioxides as potential potassium ion channel openers." Thesis, Heriot-Watt University, 1995. http://hdl.handle.net/10399/1347.

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2

Kirby, Robert William. "Investigation of the pharmacophore of BK[ca] potassium channel openers." Thesis, Sheffield Hallam University, 2008. http://shura.shu.ac.uk/19920/.

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Large conductance voltage-activated calcium-sensitive potassium channels (BK[ca]) are fundamental in the control of cellular excitability which is critical in the regulation of many physiological processes. Agents that activate the channel (openers) have been proposed to be potential therapeutics for a number of un-met clinical conditions. Several heterogeneous classes of compounds have been described as BK[ca] channel openers and preliminary pharmacophore data has arisen for synthetic molecules based on the structure of benzimidazolones. The project aimed to explore a series of novel compound
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3

Zhang, Hailin. "ATP-sensitive potassium channels and their modulation by nucleotides and potassium channel openers in vascular smooth muscle cells." Thesis, St George's, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309744.

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4

Bailey, Elizabeth Helen. "An investigation into the combination of nifedipine with potassium channel openers as potential tocolytic therapy for preterm labour, and a novel potassium channel blocker as potential therapy for post-partum haemorrhage." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/78668/.

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Background Preterm labour and post-partum haemorrhage are leading causes of pregnancy morbidity and mortality. Previous work identified potassium channels expressed in myometrium and hypothesized modulation of channels with greater expression in MSMC than VSMC will influence contractility and avoid cardiovascular effects. By combining calcium channel blockers with potassium channel openers an enhanced tocolytic effect is anticipated. VU590 inhibits Kir 7.1 and it was hypothesised would elicit a contractile effect with therapeutic potential for post-partum haemorrhage. Aim To determine the effe
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5

Amberg, Gregory C. "A-type potassium currents in gastrointestinal smooth muscle /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3060369.

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Tichenor, Jennifer Noel. "Stretch-activated potassium channels in human myometrium and aspects of cGMP signaling." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3316375.

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Hagen, Brian M. "Regulation of calcium-activated potassium channels by localized calcium transients in murine colon." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209955.

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8

Sigal, Yaron M. "Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339204.

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9

Ryan, Devon P. "Characterization of a novel inwardly rectifying potassium channel (Kir2.6) and its role in thyrotoxic hypokalemic periodic paralysis." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398884.

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10

Abu, Baker Salah. "Molecular and functional identification of the two-pore K+ channels in bladder smooth muscle." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3320570.

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11

Hallahan, Brent J. "The role of tyrosine kinases and calcineurin in the calcium-mediated modulation of the voltage-gated potassium channel, Kv1.1." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3207050.

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Thesis (Ph.D.)--Indiana University, Dept. of Neuroscience, 2006.<br>Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0118. Adviser: Joseph Farley. "Title from dissertation home page (viewed Feb. 22, 2007)."
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12

Flynn, Elaine Rose Maria. "Ionic conductances involved in the electrical activity of the canine gastrointestinal tract /." abstract and full text PDF (UNR users only), 1999. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9934138.

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13

Ro, Seungil. "SK channels : distribution, function and regulation in mouse colonic myocytes /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.

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14

Wen-Sheng and 蔡文盛. "The effect of potassium channel openers on the myotonia of mouse skeletal muscle." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/41693856640680381038.

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碩士<br>中山醫學大學<br>生物醫學科學學系碩士班<br>100<br>The purpose of this study was to investigate the effect of KCNQ (potassium channel, voltage-gated, KQT-like subfamily) openers in preventing myotonia caused by anthracene-9-carboxylic acid (9-AC, a chloride channel blocker). Myotonia is a neuromuscular disorder and characterized by the membrane hyperexcitability and slow relaxation of muscles after a contraction. An animal model of myotonia can be elicited in murine skeletal muscle by 9-AC treatment. Retigabine, flupirtine and lidocaine can inhibit the increased twitch amplitude (0.1 Hz stimulation) and re
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15

LIN, YEN-CHUNG, and 林燕君. "Synthesis and Pharmacology of Tricyclic 1-Benzopyrano[3,4-b][1,4]Oxazine Derivatives as Potassium Channel Openers." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/06973483504569290979.

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碩士<br>國立臺灣大學<br>藥學研究所<br>87<br>As rigid analogs of the prototype potassium channel opener (POC) cromakalim, a series of optically active hexahydro benzopyrano[3,4-b][1,4] oxazine derivatives have been synthesized. The PCO activity of target compounds were evaluated in vitro with preparations of spontaneous contracting rat portal vein and KCl-stimulated rat detrusor strip. Target compounds (+)-37a-c are acylation products of (4aR,10aS)-1,2,3,4a,5,10b-hexahydro-5,5-dimethyl-1-benzopyrano[3,4-b][1,4] oxazine-9-carbonitrile ((+)-41). The starting epoxide (-)-39, prepared form 6-cyano-
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16

Davies, Gareth C., M. Julie Thornton, Tracey J. Jenner, et al. "Novel and established potassium channel openers stimulate hair growth in vitromodes of action in hair follicles.: implications for their." 2005. http://hdl.handle.net/10454/4017.

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No<br>Although ATP-sensitive potassium (K(ATP)) channel openers, e.g., minoxidil and diazoxide, can induce hair growth, their mechanisms require clarification. Improved drugs are needed clinically. but the absence of a good bioassay hampers research. K(ATP) channels from various tissues contain subtypes of the regulatory sulfonylurea receptor, SUR, and pore-forming, K(+) inward rectifier subunits, Kir6.X, giving differing sensitivities to regulators. Therefore, the in vitro effects of established potassium channel openers and inhibitors (tolbutamide and glibenclamide), plus a novel, selective
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17

Chiu, Hsin-I., and 邱欣怡. "(I)I. Synthesis of Tricyclic [1]Benzopyrano[3,4-b][1,4]Oxazines as Bladder-selective Potassium Channel Openers.(II)Synthesis of D-chiro-Inositol Derivatives as Insulin Mimetics." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/25181663020983877074.

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博士<br>國立臺灣大學<br>藥學研究所<br>89<br>Abstract I. Synthesis of Tricyclic [1]Benzopyrano[3,4-b][1,4]Oxazines as Bladder-selective Potassium Channel Openers. Based on the prototype potassium channel opener (PCO) , cromakalim, a series of optically active tricyclic [1]benzopyrano[3,4-b][1,4]oxazines(16,19-24,25-26,28)have been synthesized. Also synthesized were (2S,3'S,4'R)-N-(6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-[1]benzopyran-4-yl)-2-trifluoromethylpropamide (29) and (2R,3'S,4'R)-N-(6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-[1]benzopyran-4-yl)-2-trifluoromethylpropam
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18

Liang, Pi-Hui, and 梁碧惠. "1. Synthesis and Pharmacology of N-Arylated Pyrrolidin-2-ones and Morpholin-3-ones as Potassium Channel Openers, 2. 2. Synthesis and Pharmacology of Galanthamine Analogs as Potential Agents for the Treatment of Alzheimer’s Disease." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/03739443088319720474.

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博士<br>國立臺灣大學<br>藥學研究所<br>91<br>1. Synthesis and pharmacology of N-arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers (-)-N-(4-Benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide (ZD6169, (-)-1) was recently reported to be a novel potassium channel opener (KCO), which significantly reduced micturition frequency in rats (ED50 = 0.16 mg/kg) with minimal effect on cardiovascular parameters (ED20 = 30 mg/kg). In our search for tissue-selective KCOs, N-(arylated)-1,3-oxazolidin-2,4-dione 2, morpholin-3-ones 3 - 5, pyrrolidin-2-ones 7 - 13, have been synt
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19

Shih-Chieh, Chang, and 張世杰. "Synthesis and Structure Activity Relationship of Benzopyran Potassium Channel Opener." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/75746098827301373212.

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碩士<br>中國文化大學<br>應用化學研究所<br>88<br>Abstract Cardiovascular disease (CVD) has been a menace to the folks for a long time. According to the report of the Department of Health, among the top ten list of fatal causes to the folks'' death in the 88th R.O.C calendar, CVD and heart disease took the third and forth places respectively, and hypertension tenth. Therefore, developing an anti CVD medicine becomes a prime issue in the present time. Ion channel plays an important role in physiological functions. Since Noma found potassium ion channel in 1983, its wide effects
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20

Liu, Pei-Hsun, and 劉沛勳. "The protective effect of Kv7 potassium channel opener on myotonia, epilesy and myocardical ischemia reperfusion injury." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/74n627.

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碩士<br>中山醫學大學<br>生物醫學科學學系碩士班<br>106<br>The Kv7 (KCNQ) potassium channel opener acts on the voltage-gated potassium channel to stabilize membrane potential. Recently, Kv7 potassium channel opener is a new target of drug development. In clinical, Kv7 potassium channel opener is used on the treatment of epilepsy, arrhythmia and neuropathic pain. ML213 and Retigabine are known Kv7 potassium channel opener at present. In this study, we investigated the protective effect of Kv7 potassium channel opener, ML213, Retigabine and the derivatives of Retigabine #8692 and #5540, on in vitro phrenic nerve-dia
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21

Jahromi, Babak S. "Potassium channels and cerebral vasospasm." 2003. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3097120.

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22

Chen, Mei-jung, and 陳玫蓉. "Effects of CL-065, a newly synthesized ATP-dependent potassium channel opener, on cardiovascular functions on rats." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/38867273665309348242.

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Peng, Yan Yan, and 彭嚴燕. "Effects of MJ355, a newly synthesized ATP-dependent potassium channel opener, on hemodynamics and myocardial ischemia-reperfusion injury in rats." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/45921699380214511650.

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Haass, Friederike A. "Identification of yeast proteins necessary for cell surface function of a potassium channel." Diss., 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3289302.

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