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Rozprawy doktorskie na temat „Pre-clinical imaging”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 5 lutego 2022

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1

Bianchi, Andrea. "Magnetic resonance imaging techniques for pre-clinical lung imaging." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0060/document.

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Dans ce travail, les s´séquences Imagerie par Résonance Magnétique (IRM) radiales à temps d’écho ultra-court (UTE) sont analysées pour évaluer leur potentiel dans l’étude non-invasive de différents modèles expérimentaux de maladies pulmonaires chez la souris. Chez le petit animal, les séquences radiales UTE peuvent efficacement limiter l’impact négatif sur la qualité de l’image dû au déphasage rapide des spins causé par les nombreuses interfaces air/tissu. En plus, les séquences radiales UTE sont moins sensibles aux artefacts de mouvement par rapport aux séquences Cartésiennes classiques. En c

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Almeida, Gilberto Serrano de. "Pre-clinical imaging evaluation of the PARP inhibitor rucaparib." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2033.

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Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA-binding enzyme involved in DNA repair by the base-excision pathway. The inhibition of PARP1 is being investigated as a cancer treatment. Rucaparib (CO338) is a potent PARP 31 inhibitor currently in Phase II clinical development. In this thesis P in vivo MR Spectroscopy (MRS) and Dynamic Contrast Enhanced (DCE) MRI were used to study acute effects of rucaparib on energy metabolism and tumour vasculature. 1 31 18 18 Ex vivo H and P-MRS, and in vivo [ F]FLT and [ F]FDG-PET, were used to study effects of treatment with rucaparib on tumour metabolism a

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Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.

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In this thesis, we describe several imaging techniques specifically designed and developed for the assessment of pulmonary structure, function and pathology. We then describe the application of this technology within appropriate biological systems, including the identification, tracking and assessment of lung tumors in a mouse model of lung cancer. The design and development of a Large Image Microscope Array (LIMA), an integrated whole organ serial sectioning and imaging system, is described with emphasis on whole lung tissue. This system provides a means for acquiring 3D pathology of fixed w

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Assadian, Sarah. "Rodent FDG-PET imaging for the pre-clinical assessment of novel glioma therapies." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101836.

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The rapid discovery of novel therapeutic agents, targeting the specific mechanism of cancer progression, invasion and angiogenesis, necessitates the development and validation of efficient techniques to assess the therapeutic efficacy of these drugs in vivo. Recently the development of dedicated PET scanners for the imaging of small animals, such as the microPET system (CTI Concorde R4), has allowed for the high-resolution functional and molecular imaging of murine and rodent models of disease. This study, investigates the ability of microPET imaging, using the 18F labelled 2-fluoro-2-deoxyglu

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Ambrosini, Valentina <1975&gt. "Pre-clinical imaging: small animal pet and CT applications in pneumology, oncology and cardiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1087/.

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Chen, Liu Qi. "Development and Application of AcidoCEST MRI for Evaluating Tumor Acidosis in Pre-Clinical Cancer Models." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/323450.

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Tumor acidosis is an important biomarker in cancer. We have developed a noninvasive imaging method, termed acidosis Chemical Exchange Saturation Transfer (acidoCEST) MRI to measure extracellular pH (pHe) in the tumor microenvironment. Chapter 1 introduces the importance of measuring tumor acidosis and presents various imaging modalities and their shortcoming to measure pHe. Chapter 2 describes the optimization of acidoCEST MRI for in vivo pHe measurement. The acidoCEST MRI protocol consists of a CEST-FISP acquisition and Lorentzian line shape fittings. We determined the optimal saturation time

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Jones, Bernard Lee. "Development of dosimetry and imaging techniques for pre-clinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43727.

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Cancer is one of the leading causes of death worldwide, and affects roughly 1.5 million new people in the United States every year. One of the leading tools in the detection and treatment of cancer is radiation. Tumors can be detected and identified using CT or PET scans, and can then be treated with external beam radiotherapy or brachytherapy. By taking advantage of the physical properties of gold and the biological properties of nanoparticles, gold nanoparticles (GNPs) can be used to improve both cancer radiotherapy and imaging. By infusing a tumor with GNPs, either using passive extravasati

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Landuyt, Willy. "Intra-tumoural blood vessels and hypoxia: targets for treatment and imaging to improve anti-cancer therapies pre-clinical investigations /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7247.

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9

Onthank, David C. "Prediction of "First Dose in Human" for radiopharmaceuticals/imaging agents based on allometric scaling of pharmacokinetics in pre-clinical animal models." Link to electronic dissertation, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-011006-132234/.

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Adcock, Jane Elizabeth St Vincent's Clinical School UNSW. "The reliability and clinical validity of functional magnetic resonance imaging in the assessment of language in pre-surgical patients with temporal lobe epilepsy." Awarded by:University of New South Wales. St Vincent's Clinical School, 2005. http://handle.unsw.edu.au/1959.4/22484.

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Defining language lateralisation is important to minimise morbidity in patients treated surgically for temporal lobe epilepsy (TLE). Functional magnetic resonance imaging (fMRI) offers a promising, non-invasive, alternative strategy to the Wada test. Here, fMRI has been used to study healthy controls and patients with TLE in order (i) to define language-related activation patterns and their reproducibility; (ii) to compare lateralisation determined by fMRI with that from the Wada test; and (iii) to explore the usefulness of multiple fMRI language paradigms. 18 healthy controls (12 right-handed

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Onthank, David C. "Prediction of "First Dose in Human" for Radiopharmaceuticals/Imaging Agents Based on Allometric Scaling of Pharmacokinetics in Pre-Clinical Animal Models." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-dissertations/443.

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It is an FDA requirement that the“first in human" dose be based on pre-clinical animal model efficacy and safety testing to ensure a safe entry into Phase I clinical trials. Pre-clinical safety and efficacy models range from mouse to non-human primates. Interspecies scaling of pharmacokinetic parameters is therefore important for predicting drug doses in human clinical trials, although it continues to be less than optimal. Understanding the disposition of the compound in different species through in vitro and in vivo experiments is necessary to ensure appropriate species are selected for human

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12

Thornton, R. C. "Imaging brain networks in focal epilepsy : a prospective study of the clinical application of simultaneous EEG-fMRI in pre-surgical evaluation." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1425726/.

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Epilepsy is a common disorder with significant associated morbidity and mortality. Despite advances in treatment, there remain a minority of people with pharmacoresistant focal epilepsy for whom surgery may be beneficial. It has been suggested that not enough people are offered surgical treatment, partly owing to the fact that current non-invasive techniques do not always adequately identify the seizure onset zone so that invasive EEG is required. EEG-fMRI is an imaging technique, developed in the 1990s (Ives, Warach et al. 1993) which identifies regions of interictal epileptiform discharge as

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13

Aginsky, Kerith Dana. "Clinical and imaging features of the lumbar spine in elite male schoolboy cricketers : the effect of a pre-season lumbar stabilisation intervention." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3222.

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Includes abstract.<br>Includes bibliographical references (p. 221-240).<br>Current evidence indicates that schoolboy cricketers are at a high risk of injury to the lumbar spine. This is particularly relevant in the case of fast bowlers who bowl with a high degree of shoulder counter-rotation. There, however, is a lack of evidence in the literature with respect to injury research of all cricketing disciplines, as fast bowlers receive the most attention. After reviewing the literature it was evident that the effect of a cricket-specific lumbar stabilisation exercise intervention in an attempt to

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Schädlich, Andreas Verfasser], Karsten [Akademischer Betreuer] [Mäder, Achim [Akademischer Betreuer] Göpferich, and Jörg [Akademischer Betreuer] Kreßler. "Pre‐clinical in vivo studies of parenteral drug delivery systems using non‐invasive multispectral fluorescence imaging : [kumulative Dissertation] / Andreas Schädlich. Betreuer: Karsten Mäder ; Achim Göpferich ; Jörg Kreßler." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1045194824/34.

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15

Maczka, Melissa May. "Investigations into the effects of neuromodulations on the BOLD-fMRI signal." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:96d46d4d-480b-48d7-9f2d-060e76c5f8aa.

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The blood oxygen level dependent functional MRI (BOLD-fMRI) signal is an indirect measure of the neuronal activity that most BOLD studies are interested in. This thesis uses generative embedding algorithms to investigate some of the challenges and opportunities that this presents for BOLD imaging. It is standard practice to analyse BOLD signals using general linear models (GLMs) that assume fixed neurovascular coupling. However, this assumption may cause false positive or negative neural activations to be detected if the biological manifestations of brain diseases, disorders and pharmaceutical

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16

Castets, Charles. "Développements méthodologiques en IRM pré-clinique chez le petit animal : apports de l’acquisition spirale pour l’imagerie paramétrique et fonctionnelle." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0307/document.

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L’IRM est de plus en plus utilisée pour diagnostiquer et évaluer un très grand nombre de pathologies. Cette technique présente cependant deux inconvénients majeurs. En effet, les examens restent encore très longs (notamment en imagerie 3D) et la quantification est très difficile par rapport à d’autres modalités comme la tomographie par émission de positons. L’objectif de ce travail de thèse a été de diminuer significativement les temps d’acquisition nécessaires pour l’imagerie volumique et de développer des techniques quantitatives robustes, permettant d’effectuer des suivis longitudinaux.Pour

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17

Audigier, Chloé. "Modélisation de l’ablation radiofréquence pour la planification de la résection de tumeurs abdominales." Thesis, Nice, 2015. http://www.theses.fr/2015NICE4071/document.

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L'ablation par radiofréquence (ARF) de tumeurs abdominales est rendue difficile par l’influence des vaisseaux sanguins et les variations de la conductivité thermique, compliquant la planification spécifique à un patient donné. En fournissant des outils prédictifs, les modèles biophysiques pourraient aider les cliniciens à planifier et guider efficacement la procédure. Nous introduisons un modèle mathématique détaillé des mécanismes impliqués dans l’ARF des tumeurs du foie comme la diffusion de la chaleur et la nécrose cellulaire. Il simule l’étendue de l’ablation à partir d’images médicales, d

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Teixeira, Joana Maria Rodrigues. "Automation of co-registration of pre-clinical RPC-PET images with animal MRI." Master's thesis, 2019. http://hdl.handle.net/10316/87898.

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Dissertação de Mestrado Integrado em Engenharia Física apresentada à Faculdade de Ciências e Tecnologia<br>A imagiologia médica é um dos recursos mais utilizados na medicina, sendo as suas principais aplicações no diagnóstico e terapêutica. Imagens obtidas através da fusão de duas modalidades de imagiologia médica apresentam vantagens consideráveis quando comparadas com images provenientes de uma só técnica de imagem, uma vez que combinam informação anatómica com informação funcional.Enquanto a Tomografia por Emissão de Positrões (PET) fornece informações específicas acerca do metabolismo, est

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Baydack, Richard Stephen. "Pre-clinical changes during scrapie disease progression in hamsters, detected by Magnetic Resonance Imaging." 2009. http://hdl.handle.net/1993/3131.

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Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of invariably fatal neurodegenerative diseases of both humans and animals, thought to be caused by the abnormally folded prion protein PrPSc. Prion disease research continues to be faced by a number of difficult challenges. First, the unequivocal diagnosis of most prion diseases currently requires the post-mortem collection of central nervous system tissue, either for histological examination or Western blot analysis; second, a viable treatment for clinical stage disease has not yet been identified; third, the e

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20

Yu, Jyun-gong, and 于峻功. "Complementary coded excitation for Improvement of Doppler Sensitivity in Pre-clinical Ultrasonic Imaging System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/53872233935062296584.

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碩士<br>國立臺灣科技大學<br>電機工程系<br>102<br>Coded excitation can improve the SNR by utilizing elongated waveform to increase the transmit energy. Besides, the axial resolution can be restored by pulse compressing the received echo. Thus, it can be used to enhance the sensitivity of Doppler flow estimation which it is often compromised by the weak blood flow scattering. Also, it could increase the penetration depth of high frequency ultrasound limitation which is resulted from frequency attenuation. The Golay Complementary Sequence (GCS) has the advantages of low range side lobe and low implementation co

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21

Wang, Wei-Ting, and 王瑋婷. "Utilization of molecular imaging in monitoringand evaluating pre-clinical effects ofTaiwanofungus camphoratus on cancer treatmentand its potential in cancer reversion." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/63666905562981766822.

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碩士<br>臺北醫學大學<br>生物醫學材料研究所<br>95<br>The fruiting body of Taiwanofungus camphoratus is well known in Taiwan as “niu-chang chih” or “jang-jy”. The objective of this research is to identify the bioactive compounds in Taiwanofungus camphoratus’s ethanol extract from solid-state growen with cancer reversion and anti-tumor activities. This non-invasive molecular imaging is useful in assessing tumor volume in vivo. By treating H441GL cells ( human non-small lungs cancer cells ) and HeLa cells ( human cervical cancer cells ) with ethanol extracts of Taiwanofungus camphoratus for 48 hrs. The ethanol ext

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(8781065), Daniel R. McIlrath. "A STUDY OF RADIATION-INDUCED PULMONARY FIBROSIS (RIPF) IN MOUSE MODELS USING DIAGNOSTIC IMAGING." Thesis, 2020.

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<p>Radiation-induced lung injury (RILI) is a common condition in the setting of lung and breast cancer. Often, patients who suffer from RILI experience pneumonitis and pulmonary fibrosis months after treatment. These pathologies have commonly been modeled using mice and observing their deterioration until mortality and quantifying pathology on histological sections.<b> </b></p> <p>With this study, we used a longitudinal microCT and a 7T MRI to characterize male C57Bl/6 mice irradiated with a single dose of 20 Gy to the whole thoracic area delivered by an X-Rad cabinent irradiator. CT was perf

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McCormick, Patrick Neil. "Pre-clinical evaluation of [carbon-11]-(+)-PHNO as an agonist positron emission tomography (PET) radiotracer for imaging of the high-affinity state of the dopamine D2 receptor." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442230&T=F.

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