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Rozprawy doktorskie na temat „Pregnancy and cancer”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Nevin, James. "Pregnancy-associated cervical cancer." Thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/26272.

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Ives, Angela Denise. "Breast cancer and pregnancy : how does a concurrent or subsequent pregnancy affect breast cancer diagnosis, management and outcomes?" University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0038.

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[Truncated abstract] A diagnosis of breast cancer is a life-changing event for any woman. For young women and their families it can be devastating. Women aged less than 45 years make up 20% of new cases of breast cancer diagnosed annually in Australia. With the trend for women to delay pregnancy, young women diagnosed with breast cancer may want at least the option to become pregnant after diagnosis and treatment but little is known about how pregnancy affects breast cancer or how breast cancer affects pregnancy. The aims of this thesis were to investigate how concurrent and subsequent pregna

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Larfors, Gunnar. "Pregnancy related risk factors for breast cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-634-0/.

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Ng, Tsz-yin Carina. "Illness, ideology, and identity the "pregnancy" of cancer /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38671074.

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Ng, Tsz-yin Carina, and 伍紫燕. "Illness, ideology, and identity: the "pregnancy" of cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38671074.

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LINKEVICIUTE, ALMA. "CANCER DURING PREGNANCY: A FRAMEWORK FOR ETHICAL CARE." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/449004.

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Cancer affects about 1 in 1000 pregnancies, which is estimated to account for approximately 5000 pregnancies in Europe each year. Despite affluent availability of clinical practice guidelines for cancer management in the course of pregnancy, there is very little ethical guidance consolidated for everyday use. Therefore, the aim of this work is to construct a framework, which would serve healthcare professionals as a reference tool when addressing ethical issues in cancer care during pregnancy. The framework is constructed around relational approach to respect for patient’s autonomy and ethic

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Gorman, Jessica Lynn Rickard. "Fertility, pregnancy, and breastfeeding among younger breast cancer survivors." Diss., [La Jolla] : [San Diego] : University of California, San Diego ; San Diego State University, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3356444.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.<br>Title from first page of PDF file (viewed July 14, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Cruz, Giovanna Ibeth. "Pregnancy and its association with breast cancer tumor subtypes." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144593.

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Parity is associated with a short–term increase in breast cancer (BC) risk followed by a long–term decrease in risk. BC diagnosed 5–7 years after a completed pregnancy is associated with worse outcomes. BC is not a single disease. The dual effect of pregnancy could account for the BC characteristics at presentation (i.e. younger age and more advanced disease) and worse outcomes observed among Hispanics, relative to Non–Hispanic Whites. The purpose of this study was to investigate the association of reproductive characteristics by tumor subtype in a case series of women of Mexican–descent. Case

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9

De, Roo Lisa Anne. "Smoking during first pregnancy and the risk of breast cancer /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/10884.

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10

Nguyen, Bastien. "Impact of reproductive history and pregnancy on breast cancer biology." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/278388.

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It is estimated that four in five women will give birth while one in eight women will be diagnosed with breast cancer at some point in her lifetime. It is also known that pregnancy at a young age is associated with a marked decrease in the risk of breast cancer and that this protection is different according to breast cancer subtypes. This thesis explores the impact of reproductive history on breast cancer biology and provides the molecular characterization of breast cancer diagnosed during pregnancy. The last part investigates the effect of RANKL inhibition on the biology of breast cancer in

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11

Abdel, Azim Hatem Hamdy. "Breast cancer in young women: impact of pregnancy on biology and outcome." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209357.

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In this work, we found that proliferation-related prognostic gene signatures could aid treatment decision-making independent of age. This is clinically relevant for the younger breast cancer population given the potential long-term side effects of adjuvant systemic chemotherapy and hence the need to identify patients who are less likely to benefit adjuvant chemotherapy. In addition, it was clear that young age at diagnosis adds extra biological complexity, which is independent of differences in breast cancer subtype distribution. This includes enrichment with known breast cancer targets like R

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12

Schock, Helena. "Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer." Doctoral thesis, Umeå universitet, Institutionen för medicinsk biovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102181.

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Background: The aim of this thesis was to study the relationship of pre-diagnostic circulating concentrations of sex steroid hormones (androgens, estradiol, 17-hydroxyprogesterone, and progesterone), growth factors (insulin-like growth factor-I (IGF-I), placental growth hormone (GH)), sex hormone binding globulin (SHBG), and anti-Müllerian hormone (AMH) with risk of epithelial ovarian cancer (EOC) overall, and by tumor invasiveness and histology. A longitudinal study was used to assess patterns of hormonal changes during a single pregnancy, and in two consecutive pregnancies. Materials & M

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13

Lambertini, Matteo. "Unmet fertility and pregnancy-related issues in young breast cancer patients." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/278746.

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Survival from breast cancer has significantly improved over the past years. Therefore, survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with breast cancer patients. Fertility and pregnancy-related issues represent a priority area of concern for young women with breast cancer. Despite a growing attention towards these issues has been given over the past years and is currently provided to young breast cancer patients, several grey zones persist in many domains of this field and some physicians are still uncomfortable

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14

Zhang, Yi. "Potential impact of breast cancer resistance protein on drug disposition during pregnancy /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7970.

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15

Nicholson, Leigh. "A molecular study on cytoskeletal proteins in the uterus during pregnancy and cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18820.

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The uterus has the unique ability to undergo morphological and functional changes in different biological contexts. Through the investigation of four cytoskeletal proteins, α-parvin, β-parvin, lasp-1 and palladin, during two separate events specific to the uterus, early pregnancy and endometrial carcinoma, this thesis aimed to contribute to both fields of study, whilst additionally determining comparisons and similarities in the molecular processes and proteins involved. Palladin and lasp-1 were both found to increase during the time of implantation, compared to the time of fertilisation. Lasp

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16

Rodsten, Janne Marie. "Understanding the experience of Pregnancy-Associated Breast Cancer (PABC) : an interpretative phenomenological analysis." Thesis, University of the West of England, Bristol, 2017. http://eprints.uwe.ac.uk/30561/.

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The psychological impact of breast cancer is well documented, but the experience of younger patients who are diagnosed whilst they are pregnant, is both physically and psychologically diverse from that of non-pregnant breast cancer patients, and this phenomenon has been little researched. Pregnancy-associated breast cancer (PABC) is rare but incidence rates are rising as women delay child-bearing. Currently, no guidelines to psychological management exist, and practitioners’ competence is challenged in this area. This unparalleled ‘insider’ study explores the experiences of women diagnosed wit

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17

Franklyn, Lindsey, Hemendra Mhadgut, Alok Sinha, and Sakshi Singal. "A Rare Case of Acute Promyelocytic Leukemia in Pregnancy." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/21.

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Acute promyelocytic leukemia (APL) is a clinically distinct and rare type of acute myeloid leukemia and represents an oncologic emergency. Even rarer is the incidence of APL in pregnancy with less than 60 cases described in the literature. A 33-year-old pregnant female at 34 week gestation presented to hospital with reports of abdominal pain. On admission she was found to have acute onset pancytopenia with a WBC count of 1.2, Hemoglobin of 9.7g/dl, and platelet count of 26000. Initial history, exam, and investigations including a peripheral smear, coagulation panel, liver function, vitamin b12

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18

Fleay, Brianna. "Exercise medicine in supportive care of pregnancy associated breast cancer: Feasibility and patient preferences." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2024. https://ro.ecu.edu.au/theses/2833.

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Pregnancy-associated breast cancer (PABC) refers to breast cancer diagnosed during pregnancy or postpartum. Women with PABC experience symptoms such as nausea, pain, and fatigue during pregnancy and early motherhood, which can be barriers to exercise participation. Although exercise has numerous benefits for pregnancy and postpartum health, and can improve treatment-related symptoms, there is no research on exercise for PABC patients. Utilising a mixed-methods design, the aim of this body of research was to (1) assess the existing literature around PABC, treatment of the disease and current ex

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19

VENETIS, KONSTANTINOS. "BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/951469.

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Breast cancer during pregnancy (PrBC) is a rare tumor with limited information on its immune landscape. Here, we sought to characterize the cellular composition of the tumor microenvironment (TME) and the immune transcriptome of PrBC to identify their differences from early-onset breast cancer (EOBC) in non-pregnant women. Eighty-three PrBC and 89 EOBC were selected and subjected to tumor-infiltrating lymphocytes (TILs) profiling and immunohistochemistry for CD4, CD8, forkhead box P3 (FOXP3), and programmed death-ligand 1 (PD-L1) (clone 22C3). A subset of 28 PrBC and 23 EOBC was selected for t

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20

Danastas, Kevin. "The role of vascular endothelial growth factor A in physiological and pathological angiogenesis." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17978.

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Vascular endothelial growth factor A (VEGF-A) is a major contributor to physiological and pathological angiogenesis in the body. VEGF-A exists as several isoforms varying significantly in their function and angiogenic potential due to their different exon compositions. VEGF111, the most recently discovered isoform, has unique characteristics, being the only isoform resistant to proteolytic cleavage by plasmin and is also freely diffusable. This thesis aimed to investigate the role and regulation of these isoforms in three major conditions, ovarian hyperstimulation (OH), endometriosis, and tumo

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21

Hedlund, Malin. "Exosomes and the NKG2D receptor-ligand system in pregnancy and cancer : using stress for survival." Doctoral thesis, Umeå universitet, Klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37122.

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Although not obvious at first sight, several parallels can be drawn between pregnancy andcancer. Many proliferative, invasive and immune tolerance mechanisms that supportnormal pregnancy are also exploited by malignancies to establish a nutrient supply andevade or edit the immune response of the host. The human placenta, of crucial importancefor pregnancy success, and its main cells, the trophoblast, share several features withmalignant cells such as high cell proliferation rate, lack of cell-contact inhibition andinvasiveness. Both in cancer and in pregnancy, the immune defense mechanisms,pot

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22

Velentgas, Priscilla T. "Risk of recurrence and death following breast cancer : influence of pregnancy and hormone replacement therapy /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10865.

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23

Kaijser, Magnus. "Does cancer originate in utero? : epidemiological evaluation of a hypothesis /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-151-9.

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24

CAMERONI, IRENE. "Tumore e gravidanza. Diagnosi, trattamento e outcome, l'esperienza della clinica ostetrico ginecologica di Monza." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19597.

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BACKGROUND The exact incidence of cancer during gestation is yet to be determined but it is estimated that cancer occurs in 1 in 1000 pregnancies. The most common cancers in pregnancy are those with a peak incidence during the woman‘s reproductive period such as cancer of the breast and cervix, lymphoma, leukemia and melanoma. Cancer during pregnancy is a challenge about assistance and therapy, the aim of therapy in pregnancy is to give optimal treatment to the mother without harm to the fetus. After cancer diagnosis there are following problems such as the difficulty to stage it accordin

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25

Nordor, Akpéli. "Toward the identification of cancer/placenta epigenetic switches." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB097.

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Les cellules placentaires portent un génome différent du génome maternel, puisque 50% de leurs gènes proviennent du génome paternel. Cependant, comme les cellules cancéreuses après la transformation néoplasique, elles réussissent à envahir les tissus de leur hôte, échapper à son système immunitaire et induire une angiogenèse afin d’établir la grossesse. Les cellules cancéreuses et placentaires arborent aussi une différence majeure : alors que de tels mécanismes typiques des cancers sont incontrôlés dans les cellules cancéreuses, ils sont spatialement et temporairement contrôlés dans les cell

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26

CIRIELLO, ELENA. "Tumore della mammella in gravidanza: fattori di prognosi e risultati clinici in uno studio caso-controllo." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20079.

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PURPOSE: Pregnancy-associated breast cancer (PABC) is one of the most common malignancies during pregnancy (one in 3,000 pregnancies); up to 3% of breast cancers are diagnosed in pregnancy. Our objective is to verify if women with pregnancy-associated breast cancer (PABC) have poorer outcome than nonpregnant women with breast cancer. METHODS: We register in a Cancer and Pregnancy Registry the clinical course, treatment, and disease outcome of nonpregnant women with breast cancer and of women with PABC. In a retrospective control study (2:1) we compared the women with PABC (65 cases) wit

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Viana, Laís Rosa 1988. "Avaliação do perfil de aminoácidos fetal e materno e atividade placentária em camudongas NMRI portadoras do adenocarcinoma de colon (MAC16) submetidas com dieta rica em leucina." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314497.

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Orientador: Maria Cristina Cintra Gomes Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T14:33:01Z (GMT). No. of bitstreams: 1 Viana_LaisRosa_M.pdf: 2263212 bytes, checksum: 98db6fdccbbe9b7c57c880aa72c62a0f (MD5) Previous issue date: 2012<br>Resumo: A gravidez envolve várias etapas de ajustes fisiológicos, sendo que algumas complicações clínicas podem surgir ao longo deste processo. Dentre as complicações durante a gestação, o câncer destaca-se mais pela sua coexistência com essa complexa condição metaból

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Nguyen, Nguyen M. "Transgenerational inheritance of increased breast cancer risk in mouse offspring of dams exposed to high fat N-6 polyunsaturated fatty acid diet during pregnancy." Thesis, Georgetown University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10256175.

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<p> Maternal high fat (HF) intake before and/or during pregnancy increases female offsprings’ mammary cancer risk in several preclinical models. Here I studied if maternal HF intake during pregnancy cause transgenerational increase in mammary cancer risk, and if the increase is reversible by treating adult offspring with inhibitors of histone deacetylases (HDAC) or DNA methyltransferases (DNMT).</p><p> Pregnant C57BL/6NTac mice were fed either a diet high in n-6 polyunsaturated fatty acids (HF) or control diet (CON). HF diet was given from gestational day (GD) 10 – 20 to target f

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29

Ore, Robert. "A POPULATION-BASED ANALYSIS OF PATIENT AGE AND OTHER DISPARITIES IN THE TREATMENT OF OVARIAN CANCER IN CENTRAL APPALACHIA AND KENTUCKY." UKnowledge, 2019. https://uknowledge.uky.edu/crd_etds/4.

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Objectives: Adherence to National Comprehensive Cancer Network (NCCN) guidelines for ovarian cancer treatment improves patient outcomes. The aim of this study was to assess disparities associated with ovarian cancer treatment in the state of Kentucky and central Appalachia. Methods: Data on patients diagnosed as having ovarian cancer from 2007 through 2011 were extracted from administrative claims-linked Kentucky Cancer Registry data. NCCN compliance was defined by stage, grade, surgical procedure, and chemotherapy. Selection criteria were reviewed carefully to ensure data quality and accuracy

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30

Brisbois, Maryellen D. "Chemotherapy-Induced Premature Menopause Among Latina Women With Breast Cancer: An Interpretive Description: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsn_diss/29.

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The description and interpretation of Latinas’ experience with chemotherapyinduced premature menopause from breast cancer treatment were explored in this study, which utilized an interpretive descriptive method from a feminist lens, and Knobf’s (1998, 2002) “Carrying on” theory. The specific aims of the study and the interview questions were guided by the state of the science literature. Overall, the impact of physiological effects, psychosocial effects, barriers, influencing factors that made their experience easier or harder, and how participants adjusted to a cancer diagnosis, treatment cou

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31

Werner, Mårten. "Autoimmune hepatitis in Sweden." Doctoral thesis, Umeå universitet, Medicin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18545.

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Autoimmune hepatitis (AIH) was identified as an entity by the Swedish professor Jan Waldenström in the 1950s. It was then denoted lupoid hepatitis, characterized by liver inflammation and most often affecting young women. During the years the diagnosis has become more defined (as the non A non B hepatitis has been identified as Hepatitis C) and now can be safely separated from other diseases with liver inflammation. Studies of epidemiological data and long term prognosis have been scarce in the literature. Within a collaboration between the university hospitals in Sweden, we collected what we

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32

Ferrere, Rachel. "Les enjeux psychologiques de la maladie cancéreuse chez la femme en période périnatale : le devenir mère à l'épreuve du cancer." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB187/document.

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Cette recherche exploratoire longitudinale a pour objectif principal d'évaluer l'impact psychologique de la découverte et du traitement de cancer chez la femme enceinte et chez la femme en post-partum. De manière plus précise nous évaluons l'influence de la maternité sur l'ajustement à la maladie cancéreuse et l'influence de la survenue du cancer sur le processus de parentalisation. Cette recherche permet d'appréhender le risque psychopathologique réel de cette situation comportant de nombreux éléments dépressiogènes et anxiogènes ainsi que le risque de pathologisation du lien mère-enfant. L'a

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33

Connell, Shirley Elizabeth. "Young Australian women with breast cancer : perspectives of their illness experiences." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16054/1/Shirley_Connell_Thesis.pdf.

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Young women with breast cancer have been found to experience their disease more negatively and more intensely than their older counterparts. However 'young' is not uniformly defined within the literature. Studies have reported on a wide range of ages considered to be 'young', such as samples simply divided by menopausal status or other researcher-defined parameters. For the purpose of this study, young women with breast cancer were defined as those diagnosed at 40 years of age or younger. The overarching aim of the study was to explore the problems faced by this group of young women using qual

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Connell, Shirley Elizabeth. "Young Australian Women with Breast Cancer: Perspectives of their Illness Experiences." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16054/.

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Young women with breast cancer have been found to experience their disease more negatively and more intensely than their older counterparts. However 'young' is not uniformly defined within the literature. Studies have reported on a wide range of ages considered to be 'young', such as samples simply divided by menopausal status or other researcher-defined parameters. For the purpose of this study, young women with breast cancer were defined as those diagnosed at 40 years of age or younger. The overarching aim of the study was to explore the problems faced by this group of young women using qual

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Saura, Manich Cristina. "Tratamiento del cáncer de mama diagnosticado durante el embarazo." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/454826.

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El cáncer de mama diagnosticado durante el embarazo es una entidad poco frecuente. Aún así, disponemos de datos en la literatura que avalan la seguridad del tratamiento de estas pacientes teniendo en cuenta que este debe ser lo más parecido posible a una mujer no embarazada y que debe realizarse en centros especializados que aseguren el manejo multidisciplinar con el objetivo de minimizar complicaciones obstétricas y pediátricas. Se puede realizar cirugía de la mama y la axila en cualquier momento del embarazo, tratamiento con quimioterapia basada en antraciclinas y/o taxanos a partir del segu

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Florez, Corredor Laura Maria. "Découverte du rôle trophique des lymphocytes T régulateurs mémoire résidents du tissu utérin pendant la grossesse." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066642.

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Les lymphocytes T régulateurs (Tregs) jouent un rôle dans la grossesse précoce, localement dans l'utérus et de façon systémique, dans les organes lymphoïdes secondaires et dans le sang. Dans le tissu utérin, j'ai identifié une nouvelle population de Tregs effecteurs-mémoire résidant dans le tissu (uregTrm). Avant la grossesse, uregTrm ont un profil transcriptionnel et un phénotype unique en réponse au micro-environnement utérin. Au début de la grossesse, les uregTrm prolifèrent et expriment de nouveaux gènes impliqués dans des fonctions trophiques telles que le remodelage de la matrice extrace

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Burton, LizaJoy. "Snail-Cathepsin L Signaling in Human Breast and Prostate Cancers." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2017. http://digitalcommons.auctr.edu/cauetds/60.

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Prostate and breast cancer are the leading causes of cancer-related death in men and women, respectively, and metastasis is the primary factor underlying the high mortality rates.1 Snail transcription factor is an important molecule that drives prostate and breast cancer metastasis through the process of epithelial mesenchymal transition (EMT). Proteolytic enzymes that promote invasion and metastasis such as the lysosomal cysteine protease cathepsin L (Cat L) have been shown to degrade E-cadherin, promoting the epithelial mesenchymal transition (EMT).2 It has also been shown that silencing Cat

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38

Berveiller, Paul. "Cancer du sein pendant la grossesse : interactions des taxanes avec le trophoblaste humain par une approche ex vivo et in vitro." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T029/document.

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La survenue d’un cancer du sein découvert durant la grossesse est un événement dramatique compliquant entre 1/3000 et 1/10000 grossesses, ce qui en fait le cancer le plus fréquemment rencontré chez la femme enceinte. Sur le plan thérapeutique, certaines molécules anticancéreuses peuvent être utilisées, notamment les taxanes (paclitaxel et docétaxel). Si les études cliniques rétrospectives isolées semblent plutôt rassurantes, les données concernant leur passage transplacentaire sont encore fragmentaires. Quant à leurs effets sur le placenta humain et plus particulièrement sur la fonction de tra

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Idahl, Annika. "Chlamydia trachomatis as a risk factor for infertility in women and men, and ovarian tumor development." Doctoral thesis, Umeå universitet, Obstetrik och gynekologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22239.

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Background: Chlamydia trachomatis in women is a risk factor for tubal factor infertility and extra uterine pregnancies, but the impact of a C. trachomatis infection on male fertility is unclear. It is also hypothesized that persistent infection with C. trachomatis, or other microorganisms, might initiate/promote ovarian tumor development. The aims of the thesis were to study whether C. trachomatis serum antibodies in women and men had an impact on infertility diagnoses, semen characteristics, pregnancy rates and pregnancy outcomes; furthermore, to explore associations of C. trachomatis, and My

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Miyaguti, Natália Angelo da Silva 1989. "Papel da suplementação nutricional com leucina e/ou ácido graxo poli-insaturado ômega-3 na modulação do efeitos do câncer na prole de ratas." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314495.

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Orientador: Maria Cristina Cintra Gomes Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-27T06:12:33Z (GMT). No. of bitstreams: 1 Miyaguti_NataliaAngelodaSilva_M.pdf: 7149513 bytes, checksum: e738b40c2027a8507e7b5ae2e65321e8 (MD5) Previous issue date: 2015<br>Resumo: O Resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The Abstract is available with the full electronic digital document<br>Mestrado<br>Fisiologia<br>Mestra em Biologia Funcional e Molecular

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Gokhale, Kimaya. "Why are HPV Vaccination Rates So Low?" Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/scripps_theses/1098.

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This thesis attempts to apply the theory of rational disease dynamics to the human papillomavirus by testing whether HPV vaccinations are prevalence elastic. A prevalence elastic relationship suggests that HPV vaccination rates respond positively to increasing prevalence rates of cervical cancer. Prevalence rates are measured both by incidence rates of cervical cancer and by mortality rates of cervical cancer. Data from the NIS-Teen Survey as well as data from the United States Cancer Statistics branch of the Centers for Disease Controls are used to construct a linear regression that controls

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Morisawa, Nobuko. "Magnetic Resonance Imaging Manifestations of Decidualized Endometriotic Cysts: Comparative Study With Ovarian Cancers Associated With Endometriotic Cysts." Kyoto University, 2015. http://hdl.handle.net/2433/199169.

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Monteiro, Paula Bruno. "Dynamics of offering and realization the cytology for cervical cancer in pregnant women in Fortaleza Ceara Brasil." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17484.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Cervical cancer was responsible for the death of 265,000 women in the world in 2012. With the exception of skin cancer, this tumor is the one with the greatest potential for prevention and cure when diagnosed early. The conventional Pap test (Papanicolaou) is the main strategy of screening programs for cervical cancer in Brazil and worldwide. It is known that, in developing countries, many women only seek health services when they show symptoms of disease or during pregnancy. Therefore, pregnancy can be a good opportunity to conduct

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Bahmanyar, Shahram. "Etiological aspects of gastroexophageal cancers : an epidemiological approach /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/9789173573191/.

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Geraldes, Márcio Filipe Monteiro. "Descoberta e desenvolvimento de esteróides da série pregnano com acção anticancerígena." Master's thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/2071.

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O cancro é uma patologia com elevada morbilidade e mortalidade e enorme impacto socio-económico nos dias de hoje. No entanto, apesar dos enormes avanços científicos, a sua incidência tem vindo a aumentar ao longo dos anos. Actualmente são conhecidos e utilizados vários agentes químicos no tratamento dos tumores malignos. Contudo, a sua baixa eficácia, os efeitos secundários severos associados e o aparecimento de resistências têm impulsionado a investigação na descoberta e desenvolvimento de novos fármacos e medicamentos nesta área ao longo das últimas décadas. Assim o contexto geral deste trab

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Goddard, Karen Jane. "Accidental exposure of pregnant patients to ionizing radiation during radiation therapy planning and treatment in British Columbia cancer centers." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43313.

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This project was an interdisciplinary study of a specific medical error - inadvertent radiation therapy (RT) in the treatment of female cancer patients during early pregnancy in British Columbia. RT is very damaging to the fetus during the first trimester of pregnancy and this is a very undesirable adverse event (or medical error). I explored why this error could occur by reviewing the types and causes of medical errors in general and then studying potential errors specific to RT planning and treatment. I created and administered a questionnaire of all health care professionals (HCPs) in can

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Martínez, González Sandra. "Metabolomic analysis of oxidative stress and inflammation biomarkers during chemotherapy treatment in pregnant women with breast cancer and their offspring." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671261.

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El càncer de mama associat a l’embaràs (PABC) és definit com càncer de mama diagnosticat durant l’embaràs o un any després del part. La quimioteràpia durant l’embaràs pot incrementar la producció d’estrès oxidatiu i inflamació elevant el risc de complicacions obstètriques. Per tant, vam examinar biomarcadors d’estrès oxidatiu, inflamació i de defensa antioxidant en dones amb PABC (N=17) abans del tractament, abans de cada cicle (antraciclines i paclitaxel) i al part. També es va obtenir sang de pacients amb càncer de mama sense embaràs (N=10) abans i després d’ antraciclines i dones embaras

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Gassiot, Matthieu. "Rôle du récepteur des xénobiotiques PXR (Pregnane X Receptor) et de ses gènes cibles sur la sensibilité des lignées de cancer de prostate aux inhibiteurs de kinases." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT133/document.

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De plus en plus d’inhibiteurs de kinase (IKs) sont testés dans le cancer de la prostate qui représente chez l’homme un enjeu de santé publique majeur de par son incidence (1er cancer) et sa mortalité (4ème cancer). Les essais cliniques pour évaluer l'efficacité des IKs dans cette indication ont donné des résultats mitigés malgré la présence de leurs cibles pharmacologiques dans les tumeurs de prostate (VEGF, EGFR, CMET..), pouvant faire penser que l’inefficacité serait en partie liée à la molécule elle-même et à sa pharmacocinétique/pharmacodynamie. En effet, les IKs sont sujets à un métabolis

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Matheux, Alice. "Implication de PXR, Pregnane X Receptor, dans la résistance aux inhibiteurs de kinases en cancérologie : application au cancer de la prostate et mélanome." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT049.

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La résistance clinique aux anticancéreux reste l’une des causes majeures de l’échec des traitements. Cette résistance est multifactorielle et implique un ensemble de mécanismes dont certains ne sont pas encore totalement élucidés. Parmi eux se trouvent des mécanismes impliquant les enzymes du métabolisme et du transport des médicaments dont les gènes sont majoritairement régulés par les récepteurs nucléaires, et notamment PXR (Pregnane X Receptor) ou NR1I2. Son expression et activité via l’expression de ses gènes cibles a souvent été décrite comme étant associée à la chimiorésistance dans des

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Filipov, Danielle. "Avaliação da dose fetal em radioterapia de mama, com câmara de ionização cilíndrica, usando blindagem e filtros físico e dinâmico." Universidade Tecnológica Federal do Paraná, 2010. http://repositorio.utfpr.edu.br/jspui/handle/1/1311.

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Quando uma mulher grávida é submetida à radioterapia mamária, o feto pode ser gravemente afetado pela dose periférica. Com o objetivo de verificar essa dose, um objeto simulador humanóide foi irradiado na mama esquerda. O phantom é um manequim adaptado, com alguns materiais (de densidades próximas a da água) dentro e fora do mesmo. A irradiação foi feita usando feixes de raios X de energia de 6 MeV, provenientes de um acelerador linear “Clinac 600C”. Durante as irradiações, foi empregada uma blindagem, constituída de blocos e placas de chumbo, em torno da região abdominal do manequim. Além dis

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