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Artykuły w czasopismach na temat „Pregnancy specific glycoprotein (PSG)”

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Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Timganova, V. P., M. S. Bochkova, M. B. Rayev, P. V. Khramtsov та S. A. Zamorina. "Immunoregulatory potential of pregnancy-specific β1-glycoprotein". Medical Immunology (Russia) 23, № 3 (2021): 455–68. http://dx.doi.org/10.15789/1563-0625-ipo-2170.

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The embryo, being half an antigenically “foreign” organism, should elicit a maternal immune response. During evolution, however, the mechanisms ensuring successful development of pregnancy have been formed. In particular, among factors providing immune tolerance during pregnancy are some proteins associated with pregnancy. The pregnancy-specific β 1-glycoprotein (PSG, PSG1; SP1; PSβG1) is a dominant fetoplacental protein produced by cyto- and syncytiotrophoblast cells, and it exhibits immunosuppressive properties. Our team of authors possesses a patented method for obtaining native human PSG p

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Waterhouse, Roseann, Cam Ha, and Gabriela S. Dveksler. "Murine CD9 Is the Receptor for Pregnancy-specific Glycoprotein 17." Journal of Experimental Medicine 195, no. 2 (2002): 277–82. http://dx.doi.org/10.1084/jem.20011741.

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Pregnancy-specific glycoproteins (PSGs) are a family of highly similar secreted proteins produced by the placenta. PSG homologs have been identified in primates and rodents. Members of the human and murine PSG family induce secretion of antiinflammatory cytokines in mononuclear phagocytes. For the purpose of cloning the receptor, we screened a RAW 264.7 cell cDNA expression library. The PSG17 receptor was identified as the tetraspanin, CD9. We confirmed binding of PSG17 to CD9 by ELISA, flow cytometry, alkaline phosphatase binding assays, and in situ rosetting. Anti-CD9 monoclonal antibody inh

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Timganova, Valeria, Maria Bochkova, Pavel Khramtsov, Sofia Kochurova, Mikhail Rayev та Svetlana Zamorina. "Effects of pregnancy-specific β-1-glycoprotein on the helper T-cell response". Archives of Biological Sciences 71, № 2 (2019): 369–78. http://dx.doi.org/10.2298/abs190122019t.

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Pregnancy-specific ?-1-glycoproteins (PSGs) are capable of regulating innate and adaptive immunity. As fetal antigens circulate in the blood of pregnant women, it is of particular interest to reveal the effects of PSGs on the differentiation of memory T cells in the context of maternal-fetal tolerance formation. We studied if, native PSG preparation affects helper T-cell proliferation, the frequencies of CD4+CD45R0+, CD4+CD45RA+, CD4+CD45RA+CD45R0+cells, naive CD45RA+CD45R0-CD62L+ cells (NAIVE), central memory CD45RA-CD45R0+CD62L+ cells (TCM), effector memory helper T cells (CD45RA-CD45R0+CD62

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Timganova, V. P., K. Yu Shardina, M. S. Bochkova, S. V. Uzhviyuk, D. I. Usanina та S. A. Zamorina. "Effect of pregnancy-specific β1-glycoprotein on myeloid-derived suppressor cell differentiation". Medical Immunology (Russia) 25, № 3 (2023): 513–20. http://dx.doi.org/10.15789/1563-0625-eop-2838.

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population that primarily suppress T lymphocytes in healthy pregnancies and pathologies. MDSCs are one of the key regulators of immune responses. Finding ways to control them is important for the treatment of cancer, autoimmune diseases, miscarriage, and post-transplant complications. The mechanisms of immune suppression by MDSC are: expression of CD73, ADAM17, PD -L1, production of Arg 1, iNOS, IDO, IL -10 and TGF-b1.Pregnancy-specific b1-glycoprotein (PSG) has modulatory effects on dendritic cells and macrophages that mediate

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Wynne, Freda, Melanie Ball, Andrew S. McLellan, Peter Dockery, Wolfgang Zimmermann, and Tom Moore. "Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature." Reproduction 131, no. 4 (2006): 721–32. http://dx.doi.org/10.1530/rep.1.00869.

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The pregnancy-specific glycoproteins (Psg) are secreted hormones encoded by multiple genes in rodents and primates, and are thought to act as immune modulators. The only Psg receptor identified is CD9, through which Psg17 induces cytokine production from macrophages culturedin vitro. We examined temporal and spatial aspects of Psg and CD9 expression during mouse pregnancy to determine whether their expression patterns support a role in immune modulation. Usingin situhybridisation, immunohistochemistry and RT-PCR we found Psg expression in trophoblast giant cells and in the spongiotrophoblast.P

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Brophy, Brigid K., Rachel E. MacDonald, Patricia A. McLenachan та Brian C. Mansfield. "cDNA sequence of the pregnancy-specific β1-glycoprotein-11s (PSG-11s)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1131, № 1 (1992): 119–21. http://dx.doi.org/10.1016/0167-4781(92)90110-l.

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PANZETTA-DUTARI, Graciela M., Nicolás P. KORITSCHONER, José L. BOCCO, Rodrigo NORES, Catherine I. DUMUR, and Luis C. PATRITO. "Transcription of genes encoding pregnancy-specific glycoproteins is regulated by negative promoter-selective elements." Biochemical Journal 350, no. 2 (2000): 511–19. http://dx.doi.org/10.1042/bj3500511.

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The human pregnancy-specific glycoprotein (PSG) genes comprise a family of 11 highly conserved members whose expression is maximal in placental cells and marginal in other cell types. We have investigated here the molecular basis of PSG regulation by analysing a large regulatory region of the PSG-5 gene in cells that do and do not express these genes. The promoter region (-254 to -43), which does not contain a TATA-box, large GC-rich sequences or a classical initiator, was active in all cell types analysed. Additional upstream sequences up to position -3204 repressed promoter activity. Two ind

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Rayev, M. B., L. S. Litvinova, K. A. Yurova, et al. "THE ROLE OF PREGNANCY-SPECIFIC GLYCOPROTEIN IN REGULATION OF MOLECULAR GENETIC DIFFERENTIATION MECHANISMS OF IMMUNE MEMORY T CELLS." Medical Immunology (Russia) 21, no. 1 (2019): 49–58. http://dx.doi.org/10.15789/1563-0625-2019-1-49-58.

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The role of pregnancy-specific β1-glycoprotein (PSG) in the regulation of molecular genetic factors determining the functional activity of naїve T cells and T cells of immune memoryin vitrowas studied. Human PSG was isolated with a proprietary immuno-purification method using a biospecific sorbent followed by removing of immunoglobulin contamination with a HiTrapTMProtein G HP column. Physiological concentrations of PSG were used in the experiments. They corresponded to PSG levels in the peripheral blood of pregnant woman: 1, 10 and 100 μg/ml (I, II, III trimester, respectively). The objects o

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Kammerer, Robert, Angela Ballesteros, Daniel Bonsor, et al. "Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB." Reproduction 160, no. 5 (2020): 685–94. http://dx.doi.org/10.1530/rep-20-0277.

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In early equine pregnancy, a highly invasive trophoblast cell subpopulation, the chorionic girdle cells, invade the endometrium and form endometrial cups (EC). These cells express classical MHC molecules, thereby stimulating a humoral and cellular immune response, resulting in a massive accumulation of maternal CD4+ and CD8+ T cells around the EC. Nevertheless, no immediate destruction of endometrial cups by maternal lymphoid cells occurs, presumably due to immune tolerance. Although the environment of EC is rich in TGFB and in FOXP3+, CD4+ T cells, the mechanisms leading to tolerance have not

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Streydio, Catherine, та Gilbert Vassart. "Expression of human pregnancy specific β1 glycoprotein (PSG) genes during placental development". Biochemical and Biophysical Research Communications 166, № 3 (1990): 1265–73. http://dx.doi.org/10.1016/0006-291x(90)91002-a.

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Dveksler, Gabriela, Maria Rendon-Correa, James Warren, Mirian Mendoza, Sandra M. Blois, and Angela Ballesteros. "The immuno-regulatory activity of placentally secreted pregnancy-specific glycoprotein (PSG) 1." Journal of Reproductive Immunology 159 (September 2023): 104056. http://dx.doi.org/10.1016/j.jri.2023.104056.

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Timganova, Valeria P., Kseniya Y. Shardina та Evgenia V. Gutina. "Effect of pregnancy-specific β1-glycoprotein on the expression of arginase-1 and indolamine-2,3-dioxygenase by myeloid-derived suppressor cells". Russian Journal of Immunology 26, № 3 (2023): 403–8. http://dx.doi.org/10.46235/1028-7221-10003-eot.

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Myeloid-derived suppressor cells (MDSC) - a population of immature cells of myeloid origin with inhibitory functions, mainly related to T lymphocytes. Normally, MDSC account for less than 1% of leukocytes in peripheral blood. The number of these cells increases during healthy pregnancy. However, MDSC have been shown to play a critical role in the maintenance of tumor growth and in autoimmune diseases. Because MDSC are now considered important regulators of immunity, finding ways to manipulate their functions is important for the development of therapies for malignant and autoimmune disea

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13

Charushina, Yulia A., Natalya P. Loginova, Natalia I. Gulyaeva, Vitaly S. Prokudin, Alexander V. Lyubimov, and Svetlana A. Zamorina. "Influence of PSG peptides on the morphofunctional state of the spleen in allogenous bone marrow cell transplantation." Journal of Ural Medical Academic Science 19, no. 3 (2022): 222–30. http://dx.doi.org/10.22138/2500-0918-2022-19-3-222-230.

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It is known that proteins associated with pregnancy provide immune tolerance during pregnancy. One of them is pregnancy-specific β1-glycoprotein (PSG), which has a pronounced immunomodulatory effect. Tetrapeptide fragments (YECE, YQCE, YVCS, and YACS) have been identified in the primary structure of PSG that have immunopharmacological potential. The aim of the study was to evaluate the effect of short peptide fragments of PSG on the morphological and immunohistochemical state of the spleen and its compartments during allogeneic transplantation of a suspension of red bone marrow cells in an in

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Moore, Tom, John M. Williams, Maria Angeles Becerra-Rodriguez, Matthew Dunne, Robert Kammerer, and Gabriela Dveksler. "Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations." Reproduction 163, no. 2 (2022): R11—R23. http://dx.doi.org/10.1530/rep-21-0390.

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Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at high levels where they may regulate maternal immune and vascular functions through receptor binding and modulation of cytokine and chemokine expression and activity. PSGs may have autocrine and paracrine functions in the placental bed, and PSGs can activate soluble and extracellular matrix bound TGF-β, with potentially diverse effects on multipl

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Oh, Jung Hun, Gabrielle Rizzuto, Rena Elkin, et al. "Abstract 2398: Pregnancy-specific glycoproteins in tumors are strong predictors of outcome in female lung adenocarcinoma patients." Cancer Research 85, no. 8_Supplement_1 (2025): 2398. https://doi.org/10.1158/1538-7445.am2025-2398.

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Abstract Pregnancy-specific glycoproteins (PSGs) are normally critical regulators of maternal immune tolerance during pregnancy, preventing fetal rejection by modulating innate and adaptive immune responses. Recent studies have identified that mRNA expression of PSG genes in tumors is associated with poor prognosis in lung, mesothelioma, breast, and ovarian cancers. Given their pregnancy-related function, we hypothesized that PSGs could exert sex-specific effects in some cancers. An analysis of sex-differential effects of PSGs as prognostic markers was conducted using two datasets from The Can

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Blanchon, Loïc, Rodrigo Nores, Denis Gallot, et al. "Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1." Biochemical and Biophysical Research Communications 343, no. 3 (2006): 745–53. http://dx.doi.org/10.1016/j.bbrc.2006.03.032.

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Tschentscher, Peter, Christoph Wagener, and Michael Neumaier. "Distinction of highly homologous pregnancy-specific glycoprotein (PSG) isoforms by differential absorption of antisera with recombinant PSG fusion protein domains." Journal of Immunological Methods 170, no. 2 (1994): 247–54. http://dx.doi.org/10.1016/0022-1759(94)90399-9.

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Rattila, Dunk, Im та ін. "Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions". Cells 8, № 11 (2019): 1369. http://dx.doi.org/10.3390/cells8111369.

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Human pregnancy-specific glycoproteins (PSGs) serve immunomodulatory and pro-angiogenic functions during pregnancy and are mainly expressed by syncytiotrophoblast cells. While PSG mRNA expression in extravillous trophoblasts (EVTs) was reported, the proteins were not previously detected. By immunohistochemistry and immunoblotting, we show that PSGs are expressed by invasive EVTs and co-localize with integrin 5. In addition, we determined that native and recombinant PSG1, the most highly expressed member of the family, binds to 51 and induces the formation of focal adhesion structures result

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Kromer, Beril, Daniela Finkenzeller, Jennifer Wessels, Gabriela Dveksler, John Thompson, and Wolfgang Zimmermann. "Coordinate Expression of Splice Variants of the Murine Pregnancy-Specific Glycoprotein (PSG) Gene Family During Placental Development." European Journal of Biochemistry 242, no. 2 (1996): 280–87. http://dx.doi.org/10.1111/j.1432-1033.1996.0280r.x.

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Zhou, G. Q., V. Baranov, W. Zimmermann, et al. "Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta." Placenta 18, no. 7 (1997): 491–501. http://dx.doi.org/10.1016/0143-4004(77)90002-9.

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Williams, John M., Melanie Ball, Andrew Ward, and Tom Moore. "Psg22 expression in mouse trophoblast giant cells is associated with gene inversion and co-expression of antisense long non-coding RNAs." REPRODUCTION 149, no. 1 (2015): 125–37. http://dx.doi.org/10.1530/rep-14-0390.

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Pregnancy-specific glycoproteins (PSGs) are secreted carcinoembryonic antigen (CEA)-related cell adhesion molecules-related members of the immunoglobulin superfamily and are encoded by multigene families in species with haemochorial placentation. PSGs may be the most abundant trophoblast-derived proteins in human maternal blood in late pregnancy and there is evidence that dysregulation of PSG expression is associated with gestational pathology. PSGs are produced by syncytiotrophoblast in the human placenta and by trophoblast giant cells (TGCs) and spongiotrophoblast in rodents, and are implica

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Rattila, Shemona, Florian Kleefeldt, Angela Ballesteros, et al. "Pro-angiogenic effects of pregnancy-specific glycoproteins in endothelial and extravillous trophoblast cells." Reproduction 160, no. 5 (2020): 737–50. http://dx.doi.org/10.1530/rep-20-0169.

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We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis. PSG1 is composed of four immunoglobulin-like domains but which domains of the protein bind to HS remains unknown. To analyze the interaction of PSG1 with HS, we generated several recombinant proteins, including the individual domains, chimeric proteins between two PSG1 domains, and mutants. Using flow cytometric and surface plasmon resonance studies, we determined that the B2 domain of PSG1 binds to HS

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Zhou, Guang-Qian, and Sten Hammarström. "Pregnancy-Specific Glycoprotein (PSG) in Baboon (Papio hamadryas): Family Size, Domain Structure, and Prediction of a Functional Region in Primate PSGs1." Biology of Reproduction 64, no. 1 (2001): 90–99. http://dx.doi.org/10.1095/biolreprod64.1.90.

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Singh, Shiva Pratap, Ramachandran Natesan, Nandini Sharma, Anil Kumar Goel, Manoj Kumar Singh, and Suresh Dinkar Kharche. "Assessment of pregnancy-associated glycoprotein profile in milk for early pregnancy diagnosis in goats." Animal Bioscience 34, no. 1 (2021): 26–35. http://dx.doi.org/10.5713/ajas.19.0399.

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Objective: This study was conducted to assess the level of pregnancy-associated glycoprotein (PAG) in whole and skim milk samples, and its suitability for early pregnancy diagnosis in goats.Methods: A two-step sandwich enzyme-linked immunosorbent assay (ELISA) system for estimation of milk PAG was developed and validated, which employed caprine-PAG specific polyclonal antisera. Whole and skim milk samples (n = 210 each) from fifteen multiparous goats were collected on alternate days from d 10 to d 30, and thereafter weekly till d 51 postmating. PAG levels in milk samples were estimated by ELIS

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Finkenzeller, Daniela, Beate Fischer, Sabine Lutz, Heinrich Schrewe, Takehiko Shimizu, and Wolfgang Zimmermann. "Carcinoembryonic Antigen-Related Cell Adhesion Molecule 10 Expressed Specifically Early in Pregnancy in the Decidua Is Dispensable for Normal Murine Development." Molecular and Cellular Biology 23, no. 1 (2003): 272–79. http://dx.doi.org/10.1128/mcb.23.1.272-279.2003.

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ABSTRACT The carcinoembryonic antigen (CEA) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The murine CEACAM9 and CEACAM11-related proteins as well as the pregnancy-specific glycoproteins (PSG) are secreted members of the CEA family which are differentially expressed in fetal trophoblast cell populations during placental development. PSG are essential for a successful pregnancy, possibly by protecting the semiallotypic fetus from the maternal immune system. In contrast, Ceacam10 mRNA, coding for a protein identical in structure with CEACAM11-relate

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Timganova, V. P., M. S. Bochkova, K. Yu Shardina, et al. "Effect of short PSG peptide fragments on the cytokine profile in Wistar rats during allogeneic transplantation <i>in vivo</i>." Medical Immunology (Russia) 24, no. 3 (2022): 491–506. http://dx.doi.org/10.15789/1563-0625-eos-2472.

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Pregnancy-specific beta-1-glycoprotein (PSG) is a protein with pleiotropic biological effects, particularly immunoregulatory and immunosuppressive potential. The use of recombinant PSG may exert therapeutic effects in experimental animals with induced autoimmune diseases. Recently, a search for the biological effects of short linear motifs (SLiMs) has become a new strategy for designing the pharmacological compounds. Tetrapeptide regions have been identified in the primary structure of several PSGs: YQCE, YECE and YACS, these SLiMs exhibit immunomodulatory activity. The aim of our study was to

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Younis, Laith, and Qusay Aboud. "Evaluate the effectiveness of Pregnancy-Associated Glycoprotein and Progesterone in predicting the gestational status in Goats." University of Thi-Qar Journal of agricultural research 12, no. 1 (2023): 201–10. http://dx.doi.org/10.54174/utjagr.v12i1.252.

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The objective of this study was to evaluate the PAG and P4 profiles in pregnant and non-pregnant does using Enzyme Immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA), respectively. Additionally, the study aimed to compare the sensitivity (Se), specificity (Sp), and accuracy (Acc) of pregnancy diagnosis using PAG and P4 detection in serum samples. Twenty does were synchronized using P4 sponge+eCG for 12 days, followed by breeding after estrus. Blood samples were collected at different experimental periods (22, 30, 40, and 60 days post-mating) and analyzed using EIA and ELISA. The l

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Ko, Y. G., H. J. Chung, N. Y. Lee, et al. "271 IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES IN A 35-DAY-OLD CLONED PIG FETUS USING THE ANNEALING CONTROL PRIMER SYSTEM." Reproduction, Fertility and Development 19, no. 1 (2007): 251. http://dx.doi.org/10.1071/rdv19n1ab271.

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Somatic cell nuclear transfer in pig has limitations due to the high incidence of fetal failure after embryo transfer to recipients. Reasons for the inefficient cloning are assumed to be due to abnormal and poorly developed placenta. Thus, this study was designed to determine possible genetic causes of neonatal deaths and other related abnormalities. Genes expressed specifically or prominently on Day 35 were identified in cloned pig placenta utilizing PCR technology regulated by annealing control primers (ACPs). The RNA was isolated using Trizol reagent. By utilizing 120 ACPs, 53 expressed seq

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Ruiz Álvarez, J. I., J. M. Teijeiro, A. R. Charmandarian, J. P. Haumüller, and P. E. Marini. "142 DESIGN OF ANTIBODIES SPECIFIC FOR PEPTIDES PRESENT EXCLUSIVELY IN DIFFERENT MEMBERS OF THE PREGNANCY ASSOCIATED GLYCOPROTEINS FAMILY." Reproduction, Fertility and Development 22, no. 1 (2010): 230. http://dx.doi.org/10.1071/rdv22n1ab142.

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Accurate diagnosis of non-pregnancy and prompt re-enlistment of cattle into an appropriate breeding protocol are essential components of successful reproductive programs. The search for biochemical markers of early pregnancy has led to the characterization of the pregnancy-associated glycoproteins (PAG), a large family expressed exclusively in the placenta. In cattle, the PAG family is composed of at least 22 translated genes, with different spatiotemporal expression (Telugu B. et al. 2009 BMC Genomics 10, 185). The PAG may be detected in placenta and some members have been detected in serum b

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Teglund, Stephan, Anne Olsen, Wasif Noor Khan, Lars Frångsmyr, and Sten Hammarström. "The Pregnancy-Specific Glycoprotein (PSG) Gene Cluster on Human Chromosome 19: Fine Structure of the 11 PSG Genes and Identification of 6 New Genes Forming a Third Subgroup within the Carcinoembryonic Antigen (CEA) Family." Genomics 23, no. 3 (1994): 669–84. http://dx.doi.org/10.1006/geno.1994.1556.

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Fernández-Alarcón, Claudia, Grace Buchholz, Heidi Contreras, et al. "Protection against Congenital CMV Infection Conferred by MVA-Vectored Subunit Vaccines Extends to a Second Pregnancy after Maternal Challenge with a Heterologous, Novel Strain Variant." Viruses 13, no. 12 (2021): 2551. http://dx.doi.org/10.3390/v13122551.

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Maternal reinfection of immune women with novel human cytomegalovirus (HCMV) strains acquired during pregnancy can result in symptomatic congenital CMV (cCMV) infection. Novel animal model strategies are needed to explore vaccine-mediated protections against maternal reinfection. To investigate this in the guinea pig cytomegalovirus (GPCMV) model, a strictly in vivo-passaged workpool of a novel strain, the CIDMTR strain (dose, 1 × 107 pfu) was used to infect dams that had been challenged in a previous pregnancy with the 22122 strain, following either sham-immunization (vector only) or vaccinat

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Contreras, Heidi, Felix Wussow, Claudia Fernández-Alarcón, et al. "MVA-Vectored Pentameric Complex (PC) and gB Vaccines Improve Pregnancy Outcome after Guinea Pig CMV Challenge, but Only gB Vaccine Reduces Vertical Transmission." Vaccines 7, no. 4 (2019): 182. http://dx.doi.org/10.3390/vaccines7040182.

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(1) Background: A congenital cytomegalovirus (cCMV) vaccine is a major research priority, but the essential glycoprotein target(s) remain unclear. We compared CMV gB (gpgB), gH/gL (gp75/gL), and pentameric complex (gpPC, composed of gH/gL/GP129/GP131/GP133) vaccines in a guinea pig CMV (GPCMV) congenital infection model. (2) Methods: Modified vaccinia virus Ankara (MVA) vaccines expressing GPCMV glycoproteins were used to immunize GPCMV-seronegative, female Hartley guinea pigs (three-dose series, 3 × 107 pfu/dose). After pregnancy was established, the dams underwent an early third-trimester ch

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Sharma, Karlie R., Shemona Rattila, Patricia Kiesler, et al. "Graft Versus Host Disease (GvHD) Is Attenuated By Administration of Pregnancy Specific Glycoproteins through Induction of Immune Tolerance." Blood 126, no. 23 (2015): 4278. http://dx.doi.org/10.1182/blood.v126.23.4278.4278.

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Abstract Hematopoietic stem cell transplantation is curative for many disorders; however, it can be associated with significant morbidity and mortality, often as a result of graft versus host disease (GvHD). GvHD is an immune mediated reaction in which donor T-cells recognize the host antigens as foreign, causing donor T-cells to proliferate and attack host tissues. Establishment of a tolerogenic immune environment while preserving immune response to infectious agents and malignancy is required for successful bone marrow transplantationand GvHD presents a significant obstacle to this. Pregnanc

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Kammerer, Robert, Martin Mansfeld, Jana Hänske, et al. "Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup." BMC Genomics 18, no. 1 (2017): 717. https://doi.org/10.5281/zenodo.13452692.

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(Uploaded by Plazi for the Bat Literature Project) Background: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed

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Kammerer, Robert, Martin Mansfeld, Jana Hänske, et al. "Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup." BMC Genomics 18, no. 1 (2017): 717. https://doi.org/10.5281/zenodo.13452692.

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(Uploaded by Plazi for the Bat Literature Project) Background: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed

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Kammerer, Robert, Martin Mansfeld, Jana Hänske, et al. "Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup." BMC Genomics 18, no. 1 (2017): 717. https://doi.org/10.5281/zenodo.13452692.

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(Uploaded by Plazi for the Bat Literature Project) Background: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed

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Kammerer, Robert, Martin Mansfeld, Jana Hänske, et al. "Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup." BMC Genomics 18, no. 1 (2017): 717. https://doi.org/10.5281/zenodo.13452692.

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(Uploaded by Plazi for the Bat Literature Project) Background: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed

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Kammerer, Robert, Martin Mansfeld, Jana Hänske, et al. "Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup." BMC Genomics 18, no. 1 (2017): 717. https://doi.org/10.5281/zenodo.13452692.

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(Uploaded by Plazi for the Bat Literature Project) Background: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed

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AKKUŞ, TUĞRA, and ÖMER YAPRAKCI. "Determination of pregnancy protein levels to distinguish between singleton and twin pregnancies in Awassi sheep." Medycyna Weterynaryjna 77, no. 12 (2021): 6597–2021. http://dx.doi.org/10.21521/mw.6597.

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Determining the fetal number to avoid pregnant sheep management, feeding, and delivery issues is of vital importance. This study aimed to determine the levels of pregnancy-associated glycoprotein (PAG) and pregnancy-specific protein B (PSPB), which are pregnancy proteins, to accurately predict singleton and twin pregnancies in Awassi sheep. A total of 40 Awassi sheep were used for the study. According to the number of offspring, pregnant ewes were separated into two groups. The study's first group (Group 1) included singleton pregnant ewe (n=20), while the second group (Group 2) included twin

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Heyman, Y., P. Chavatte-Palmer, N. Melo de Sousa, et al. "37 PREGNANCY-ASSOCIATED GLYCOPROTEIN (PAG) PROFILES DURING THE PERI-IMPLANTATION PERIOD IN RECIPIENTS CARRYING BOVINE SOMATIC CLONES: PRELIMINARY RESULTS." Reproduction, Fertility and Development 17, no. 2 (2005): 168. http://dx.doi.org/10.1071/rdv17n2ab37.

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Bovine pregnancy-associated glycoproteins (bPAGs) are secreted by binucleate cells of the placenta and can be assayed in maternal plasma as indicators of pregnancy and markers for the functional status of the trophoblast. The concentrations of PAGs vary differentially during the peri-implantation period. Large offspring syndrome (LOS) and abnormal placentation have been associated in cloned fetuses with abnormally increased pregnancy-specific protein 60 (PSP60). The aim of this study was to investigate the evolution of plasma levels of PAGs measured by the use of three different RIA systems in

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Do, Hyun-Jin, Jae-Hwan Kim, Lalantha R. Abeydeera, et al. "Expression of pregnancy-associated glycoprotein 1 and 2 genes in in vivo, in vitro and parthenogenetically derived preimplantation pig embryos." Zygote 9, no. 3 (2001): 245–50. http://dx.doi.org/10.1017/s0967199401001265.

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The objective of this study was to determine whether porcine PAG (poPAG) genes are expressed in embryos as they develop from the 1-cell stage to expanded blastocysts, and whether expression differed according to how embryos had been derived. Embryos at various preimplantation stages were assayed after in vivo fertilisation, after in vitro fertilisation of in vitro-matured oocytes, or following parthenogenetic activation of in vitro-matured oocytes. The presence of PAG transcripts was determined at the1-, 2-, and 4-cell, compact morula and blastocyst stages by reverse transcription-PCR procedur

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Mathews, James C., Saad Nadeem, Maryam Pouryahya, et al. "Functional network analysis reveals an immune tolerance mechanism in cancer." Proceedings of the National Academy of Sciences 117, no. 28 (2020): 16339–45. http://dx.doi.org/10.1073/pnas.2002179117.

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We present a technique to construct a simplification of a feature network which can be used for interactive data exploration, biological hypothesis generation, and the detection of communities or modules of cofunctional features. These are modules of features that are not necessarily correlated, but nevertheless exhibit common function in their network context as measured by similarity of relationships with neighboring features. In the case of genetic networks, traditional pathway analyses tend to assume that, ideally, all genes in a module exhibit very similar function, independent of relatio

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Arnold, Daniel R., Roberta C. Gaspar, Carlos V. da Rocha, et al. "Nuclear transfer alters placental gene expression and associated histone modifications of the placental-specific imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2) in cattle." Reproduction, Fertility and Development 29, no. 3 (2017): 458. http://dx.doi.org/10.1071/rd15132.

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Abnormal placental development is frequent in nuclear transfer (NT) pregnancies and is likely to be associated with altered epigenetic reprogramming. In the present study, fetal and placental measurements were taken on Day 60 of gestation in cows with pregnancies produced by AI, IVF and NT. Placentas were collected and subjected to histological evaluation, the expression of genes important in trophoblast differentiation and expression of the placental imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2), as well as chromatin immunoprecipitation (ChIP) for histone marks w

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Radena, Nenova. "COMPARATIVE STUDIES OF DIFFERENT METHODS FOR EARLY DIAGNOSIS OF PREGNANCY BASED ON DETERMINATION OF PROGESTERONE LEVELS AND PAG IN BUFFALOES OF THE BULGARIAN MURRA BREED." Tradition and Modernity in Veterinary Medicine 8, no. 1 (2023): 81–87. https://doi.org/10.5281/zenodo.8174845.

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The aim of the present study was to perform a comparative evaluation of the methods for early diagnosis of pregnancy in buffalo cows of the Bulgarian Murrah breed by determining the concentrations of progesterone in serum, the P4 Rapid test in milk and the proteins associated with pregnancy in serum and milk. Blood samples were obtained from 57 buffalo cows, as well as 55 milk samples on the 23rd (progesterone determination in serum and milk) and 28th day (PAG determination in serum and milk) after artificial insemination. We interpreted the results of the rapid P4 test according to the manufa

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Chou, Janice, та Cathie Plouzek. "Pregnancy-Specific β1-Glycoprotein". Seminars in Reproductive Medicine 10, № 02 (1992): 116–26. http://dx.doi.org/10.1055/s-2007-1018867.

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Touzard, E., P. Reinaud, O. Dubois, et al. "100 BOVINE PREGNANCY-ASSOCIATED GLYCOPROTEINS ARE ALLOCATED TO COTYLEDONARY OR INTERCOTYLEDONARY TROPHOBLAST ACCORDING TO THEIR PHYLOGENETIC ORIGIN." Reproduction, Fertility and Development 25, no. 1 (2013): 197. http://dx.doi.org/10.1071/rdv25n1ab100.

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The pregnancy-associated glycoproteins (PAG) form a multigenic family of aspartic peptidases specifically expressed within the trophoblast of the ruminant placenta. In Bos taurus, this family is composed of 21 members segregated into 2 phylogenetic groups. The PAG are mainly produced by the cotyledons, which are discrete areas of massive interdigitations between the maternal endometrium and the foetal trophoblast. Cotyledons are separated by the flat cell layer of intercotyledonary trophoblast areas. According to former studies, modern PAG (PAG I) are produced by binucleate trophoblastic cells

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Lesley Shupert, W., and Wai-Yee Chan. "Pregnancy specific ?1-glycoprotein in human intestine." Molecular and Cellular Biochemistry 120, no. 2 (1993): 159–70. http://dx.doi.org/10.1007/bf00926089.

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Onyemelukwe, G. C., C. C. Ekwempu та L. C. Alexander. "Pregnancy-specific β-glycoprotein (SP1) in normal pregnancy in Nigeria". International Journal of Gynecology & Obstetrics 23, № 4 (1985): 347–49. http://dx.doi.org/10.1016/0020-7292(85)90032-3.

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BRAUNSTEIN, GLENN D., та RICARDO H. ASCH. "Pregnancy-Specific β1-Glycoprotein Concentrations throughout Pregnancy in the Rhesus Monkey*". Journal of Clinical Endocrinology & Metabolism 62, № 6 (1986): 1264–70. http://dx.doi.org/10.1210/jcem-62-6-1264.

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Zamorina, S. A., та M. B. Rayev. "Immunomodulating effects of human pregnancy-specific β1-glycoprotein". Human Physiology 41, № 1 (2015): 98–103. http://dx.doi.org/10.1134/s0362119715010144.

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